1QGN

cystathionine gamma-synthase from nicotiana tabacum

• Total interactions analyzed: 28
• Total true interactions: 15
• Strongest Interaction:
  • Chains: F-G
  • Int. Res.: 160
  • Norm. En. per Res.: -4.8841
• Hub Node: B(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-52.8631	2.4565	-201.154	-251.5606	78	9	10	8624	0	8	6
A-C	-77.6439	5.9862	-660.308	-731.9657	246	24	29	29517	0	26	41
A-D	-124.8412	-95.6294	-513.244	-733.7146	159	38	11	20890	9	71	55
B-C	-160.6095	-95.1507	-523.895	-779.6552	160	32	11	20619	8	72	55
B-D	-80.8782	6.1028	-662.111	-736.8863	246	30	29	29379	0	26	40
B-E	-41.4792	-45.1355	-59.8017	-146.4164	47	5	0	2857	3	26	26
B-H	0.0	9.5735	-9.6713	-0.0978	28	0	0	762	2	9	10
C-D	-60.7686	2.4112	-203.367	-261.7244	76	11	10	8607	0	8	6
C-H	0.0	-5.847	-18.6826	-24.5296	41	0	0	1347	0	21	17
E-F	-56.5797	2.4807	-205.15	-259.2491	78	10	10	8648	0	8	6
E-G	-78.1757	1.4445	-665.24	-741.9712	246	33	29	29656	0	26	41
E-H	-116.7797	-94.2191	-522.262	-733.2608	158	33	11	21158	8	71	55
F-G	-158.1547	-96.3861	-526.923	-781.4638	160	37	11	20865	8	72	55
F-H	-76.0776	1.5177	-641.983	-716.5429	245	25	29	29113	0	24	40
G-H	-69.3929	2.4674	-205.019	-271.9445	78	13	10	8711	0	8	6

Interface residues

• A-B: ALA104A, ALA104B, ALA76A, ALA76B, ALA86A, ALA86B, ARG103A, ARG103B, ARG305A, ARG305B, ARG67A, ARG67B, ARG70A, ARG70B, ASN113A, ASN113B, ASN298A, ASN298B, ASN83A, ASN83B, ASN90A, ASN90B, ASP75A, ASP75B, GLU107A, GLU107B, GLU66A, GLU66B, GLU94A, GLU94B, GLY109A, GLY69A, GLY69B, GLY71A, GLY71B, ILE72A, ILE72B, ILE77A, ILE77B, LEU302B, PHE106A, PHE106B, PHE88A, PHE88B, PHE89A, PHE89B, PRO114A, PRO114B, PRO297A, PRO297B, PRO80A, PRO80B, SER105A, SER105B, SER85A, SER85B, THR115A, THR115B, THR74A, THR74B, THR78A, THR78B, THR79A, THR79B, THR84A, THR84B, TYR108A, TYR108B, TYR301A, TYR301B, TYR87A, TYR87B, VAL73A, VAL73B, VAL81A, VAL81B, VAL82A, VAL82B
• A-C: ALA136A, ALA136C, ALA141A, ALA141C, ALA148A, ALA148C, ALA152A, ALA152C, ALA259C, ALA271A, ALA271C, ALA294A, ALA294C, ALA299A, ALA299C, ALA300A, ALA300C, ALA374A, ALA374C, ALA379A, ALA379C, ALA386A, ALA386C, ALA400A, ALA400C, ALA86A, ALA86C, ARG102A, ARG102C, ARG110A, ARG110C, ARG164A, ARG164C, ARG167A, ARG167C, ASN113A, ASN113C, ASN267A, ASN267C, ASN286A, ASN286C, ASN296A, ASN296C, ASN298A, ASN298C, ASN83A, ASN83C, ASN90A, ASN90C, ASP268A, ASP268C, ASP378A, ASP378C, ASP397A, ASP397C, ASP406A, ASP406C, ASP97A, ASP97C, CYS140A, CYS140C, GLN398A, GLN398C, GLU100A, GLU100C, GLU107A, GLU107C, GLU171A, GLU171C, GLU94A, GLU94C, GLY109A, GLY109C, GLY112A, GLY112C, GLY138A, GLY138C, GLY153A, GLY153C, GLY154C, GLY178A, GLY178C, GLY292A, GLY292C, GLY293A, GLY293C, GLY391A, GLY391C, HIS266A, HIS266C, HIS288A, HIS288C, HIS289A, HIS289C, ILE168A, ILE168C, ILE170A, ILE170C, ILE173A, ILE173C, ILE179A, ILE179C, ILE290A, ILE290C, ILE303A, ILE303C, ILE385A, ILE385C, ILE395A, ILE395C, ILE401A, ILE401C, ILE96A, ILE96C, LEU146A, LEU146C, LEU147A, LEU147C, LEU149A, LEU149C, LEU174A, LEU174C, LEU270A, LEU270C, LEU287A, LEU287C, LEU291A, LEU291C, LEU295A, LEU295C, LEU302A, LEU302C, LEU370A, LEU370C, LEU371A, LEU371C, LEU95A, LEU95C, LYS101A, LYS101C, LYS165A, LYS165C, LYS176A, LYS176C, LYS261A, LYS261C, LYS375A, LYS375C, LYS91A, LYS91C, LYS99A, LYS99C, MET135A, MET135C, MET139A, MET139C, MET177A, MET177C, MET402A, MET402C, PHE106A, PHE106C, PHE169A, PHE169C, PHE376A, PHE376C, PHE389A, PHE389C, PHE88A, PHE88C, PHE89A, PHE89C, PHE98A, PHE98C, PRO151A, PRO151C, PRO175A, PRO175C, PRO297A, PRO297C, PRO383A, PRO383C, PRO387A, PRO387C, PRO399A, PRO399C, SER105A, SER105C, SER137A, SER137C, SER142A, SER142C, SER258A, SER258C, SER388A, SER388C, SER403A, SER403C, SER85A, SER85C, SER93A, SER93C, THR143A, THR143C, THR166A, THR166C, THR172A, THR172C, THR260A, THR260C, THR373A, THR373C, THR84A, THR84C, THR92A, THR92C, TRP405A, TRP405C, TYR108A, TYR108C, TYR111A, TYR111C, TYR163A, TYR163C, TYR301A, TYR301C, TYR384A, TYR384C, TYR404A, TYR404C, TYR87A, TYR87C, VAL144A, VAL144C, VAL150A, VAL150C, VAL269A, VAL269C, VAL377A, VAL377C, VAL396A, VAL396C, VAL81A, VAL81C, VAL82A, VAL82C
• A-D: ALA299A, ALA299D, ALA386A, ALA386D, ALA436A, ALA436D, ALA51A, ALA51D, ALA61A, ALA61D, ALA76A, ALA76D, ARG305A, ARG305D, ARG313A, ARG313D, ARG67A, ARG67D, ARG70A, ARG70D, ASN267A, ASN267D, ASN298A, ASN298D, ASN55A, ASN55D, ASP268A, ASP268D, ASP430A, ASP430D, ASP432A, ASP432D, ASP433A, ASP433D, ASP437A, ASP437D, ASP57A, ASP57D, ASP75A, ASP75D, CYS392A, CYS392D, GLN315A, GLN315D, GLN316A, GLN316D, GLN317A, GLN317D, GLN440A, GLN440D, GLU393A, GLU393D, GLU429A, GLU429D, GLU66A, GLU66D, GLY264A, GLY264D, GLY265A, GLY265D, GLY306A, GLY306D, GLY391A, GLY391D, GLY427A, GLY427D, GLY58A, GLY58D, GLY69A, GLY69D, HIS266A, HIS266D, HIS311A, HIS311D, HIS63A, HIS63D, ILE303A, ILE303D, ILE304A, ILE304D, ILE382A, ILE382D, ILE385A, ILE385D, ILE395A, ILE395D, ILE62A, ILE62D, ILE77A, ILE77D, LEU263A, LEU263D, LEU302A, LEU302D, LEU310A, LEU310D, LEU312A, LEU312D, LEU380A, LEU380D, LEU434A, LEU434D, LEU54A, LEU54D, LEU68A, LEU68D, LYS122A, LYS122D, LYS308A, LYS308D, LYS381A, LYS381D, MET307A, MET307D, PHE389A, PHE389D, PHE431A, PHE431D, PHE53A, PHE53D, PRO383A, PRO383D, PRO387A, PRO387D, SER388A, SER388D, SER394A, SER394D, SER52A, SER52D, SER56A, SER56D, SER59A, SER59D, THR309A, THR309D, THR320A, THR74A, THR74D, THR78A, THR78D, THR79A, THR79D, TYR301A, TYR301D, TYR384A, TYR384D, VAL269A, VAL269D, VAL314A, VAL314D, VAL396A, VAL396D, VAL428A, VAL428D, VAL60A, VAL60D, VAL81A, VAL81D
• B-C: ALA299B, ALA299C, ALA386B, ALA386C, ALA436B, ALA436C, ALA51B, ALA51C, ALA61B, ALA61C, ALA76B, ALA76C, ARG305B, ARG305C, ARG313B, ARG313C, ARG67B, ARG67C, ARG70B, ARG70C, ASN267B, ASN267C, ASN298B, ASN298C, ASN55B, ASN55C, ASP268B, ASP268C, ASP430B, ASP430C, ASP432B, ASP432C, ASP433B, ASP433C, ASP437B, ASP437C, ASP57B, ASP57C, ASP75B, ASP75C, CYS392B, CYS392C, GLN315B, GLN315C, GLN316B, GLN316C, GLN317B, GLN317C, GLN440B, GLN440C, GLU393B, GLU393C, GLU429B, GLU429C, GLU66B, GLU66C, GLY264B, GLY264C, GLY265B, GLY265C, GLY306B, GLY306C, GLY391B, GLY391C, GLY427B, GLY427C, GLY58B, GLY58C, GLY69B, GLY69C, HIS266B, HIS266C, HIS311B, HIS311C, HIS63B, HIS63C, ILE303B, ILE303C, ILE304B, ILE304C, ILE382B, ILE382C, ILE385B, ILE385C, ILE395B, ILE395C, ILE62B, ILE62C, ILE77B, ILE77C, LEU263B, LEU263C, LEU302B, LEU302C, LEU310B, LEU310C, LEU312B, LEU312C, LEU380B, LEU380C, LEU434B, LEU434C, LEU54B, LEU54C, LEU68B, LEU68C, LYS122B, LYS122C, LYS308B, LYS308C, LYS381B, LYS381C, MET307B, MET307C, PHE389B, PHE389C, PHE431B, PHE431C, PHE53B, PHE53C, PRO383B, PRO383C, PRO387B, PRO387C, SER388B, SER388C, SER394B, SER394C, SER52B, SER52C, SER56B, SER56C, SER59B, SER59C, THR309B, THR309C, THR74B, THR74C, THR78B, THR78C, THR79B, THR79C, TYR301B, TYR301C, TYR384B, TYR384C, TYR50B, TYR50C, VAL269B, VAL269C, VAL314B, VAL314C, VAL396B, VAL396C, VAL428B, VAL428C, VAL60B, VAL60C, VAL81B, VAL81C
• B-D: ALA136B, ALA136D, ALA141B, ALA141D, ALA148B, ALA148D, ALA152B, ALA152D, ALA271B, ALA271D, ALA294B, ALA294D, ALA299B, ALA299D, ALA300B, ALA300D, ALA374B, ALA374D, ALA379B, ALA379D, ALA386B, ALA386D, ALA400B, ALA400D, ALA86B, ALA86D, ARG102B, ARG102D, ARG110B, ARG110D, ARG164B, ARG164D, ARG167B, ARG167D, ASN113B, ASN113D, ASN267B, ASN267D, ASN286B, ASN286D, ASN296B, ASN296D, ASN298B, ASN298D, ASN83B, ASN83D, ASN90B, ASN90D, ASP268B, ASP268D, ASP378B, ASP378D, ASP397B, ASP397D, ASP406B, ASP406D, ASP97B, ASP97D, CYS140B, CYS140D, GLN398B, GLN398D, GLU100B, GLU100D, GLU107B, GLU107D, GLU171B, GLU94B, GLU94D, GLY109B, GLY109D, GLY112B, GLY112D, GLY138B, GLY138D, GLY153B, GLY153D, GLY154B, GLY178B, GLY178D, GLY265D, GLY292B, GLY292D, GLY293B, GLY293D, GLY391B, GLY391D, HIS266B, HIS266D, HIS288B, HIS288D, HIS289B, HIS289D, ILE168B, ILE168D, ILE170B, ILE170D, ILE173B, ILE173D, ILE179B, ILE179D, ILE290B, ILE290D, ILE303B, ILE303D, ILE385B, ILE385D, ILE395B, ILE395D, ILE401B, ILE401D, ILE96B, ILE96D, LEU146B, LEU146D, LEU147B, LEU147D, LEU149B, LEU149D, LEU174B, LEU174D, LEU270B, LEU270D, LEU287B, LEU287D, LEU291B, LEU291D, LEU295B, LEU295D, LEU302B, LEU302D, LEU370B, LEU370D, LEU371B, LEU371D, LEU95B, LEU95D, LYS101B, LYS101D, LYS165B, LYS165D, LYS176B, LYS176D, LYS261B, LYS261D, LYS375B, LYS375D, LYS91B, LYS91D, LYS99B, LYS99D, MET135B, MET135D, MET139B, MET139D, MET177B, MET177D, MET402B, MET402D, PHE106B, PHE106D, PHE169B, PHE169D, PHE376B, PHE376D, PHE389B, PHE389D, PHE88B, PHE88D, PHE89B, PHE89D, PHE98B, PHE98D, PRO151B, PRO151D, PRO175B, PRO175D, PRO297B, PRO297D, PRO383B, PRO383D, PRO387B, PRO387D, PRO399B, PRO399D, SER105B, SER105D, SER137B, SER137D, SER142B, SER142D, SER258B, SER258D, SER388B, SER388D, SER403B, SER403D, SER85B, SER85D, SER93B, SER93D, THR143B, THR143D, THR166B, THR166D, THR172B, THR172D, THR260B, THR260D, THR373B, THR373D, THR84B, THR84D, THR92B, THR92D, TRP405B, TRP405D, TYR108B, TYR108D, TYR111B, TYR111D, TYR163B, TYR163D, TYR301B, TYR301D, TYR384B, TYR384D, TYR404B, TYR404D, TYR87B, TYR87D, VAL144B, VAL144D, VAL150B, VAL150D, VAL269B, VAL269D, VAL377B, VAL377D, VAL396B, VAL396D, VAL422D, VAL81B, VAL81D, VAL82B, VAL82D
• B-E: ALA330B, ALA351E, ARG323E, ARG335B, ASN244E, ASN318E, ASN420B, ASP367B, ASP369B, ASP430E, ASP432E, GLN315E, GLN343B, GLN343E, GLN354E, GLU326E, GLU329B, GLU365B, GLY341E, GLY357E, GLY368B, HIS331B, HIS336B, HIS345B, HIS348E, HIS349E, ILE445B, LEU322E, LEU342B, LEU342E, LYS333B, LYS352E, LYS353E, LYS435E, MET355E, PHE358E, PHE431E, PRO332B, PRO346B, SER319E, SER344B, SER344E, THR356E, THR372B, VAL334B, VAL337B, VAL366B
• B-H: ARG323B, ARG323H, ASP432B, ASP432H, GLN315H, GLN343B, GLN343H, GLU326B, GLU326H, GLY357H, HIS348H, ILE327B, ILE327H, LEU322B, LEU322H, LYS352B, LYS352H, LYS435B, LYS435H, MET324B, MET355B, PHE358H, PHE431B, PHE431H, SER319B, SER319H, THR356B, THR356H
• C-D: ALA104C, ALA104D, ALA76C, ALA76D, ALA86C, ALA86D, ARG103C, ARG103D, ARG305C, ARG305D, ARG67C, ARG67D, ARG70C, ARG70D, ASN113C, ASN113D, ASN298C, ASN298D, ASN83C, ASN83D, ASN90C, ASN90D, ASP75C, ASP75D, GLU107C, GLU107D, GLU66C, GLU66D, GLU94C, GLU94D, GLY109C, GLY69C, GLY69D, GLY71C, GLY71D, ILE72C, ILE72D, ILE77C, ILE77D, LEU302C, PHE106C, PHE106D, PHE88C, PHE88D, PHE89C, PHE89D, PRO114C, PRO114D, PRO80C, PRO80D, SER105C, SER105D, SER85C, SER85D, THR115C, THR115D, THR74C, THR74D, THR78C, THR78D, THR79C, THR79D, THR84C, THR84D, TYR108C, TYR108D, TYR301C, TYR301D, TYR87C, TYR87D, VAL73C, VAL73D, VAL81C, VAL81D, VAL82C, VAL82D
• C-H: ALA330C, ALA330H, ARG323C, ARG335H, ASN318C, ASP367H, ASP432C, ASP443H, GLN315C, GLN316C, GLN343C, GLN343H, GLU326C, GLU326H, GLU329H, GLY341C, GLY357C, GLY368H, HIS331H, HIS336H, HIS348C, ILE327C, ILE445H, LEU322C, LEU342C, LEU342H, LEU442H, LYS333H, LYS352C, LYS435C, PHE358C, PHE431C, PRO332H, SER319C, SER344H, SER444H, THR356C, THR372H, TYR339C, VAL334H, VAL337H
• E-F: ALA104E, ALA104F, ALA76E, ALA76F, ALA86E, ALA86F, ARG103E, ARG103F, ARG305E, ARG305F, ARG67E, ARG67F, ARG70E, ARG70F, ASN113E, ASN113F, ASN298E, ASN298F, ASN83E, ASN83F, ASN90E, ASN90F, ASP75E, ASP75F, GLU107E, GLU107F, GLU66E, GLU66F, GLU94E, GLU94F, GLY69E, GLY69F, GLY71E, GLY71F, ILE72E, ILE72F, ILE77E, ILE77F, LEU302E, LEU302F, PHE106E, PHE106F, PHE88E, PHE88F, PHE89E, PHE89F, PRO114E, PRO114F, PRO297E, PRO297F, PRO80E, PRO80F, SER105E, SER105F, SER85E, SER85F, THR115E, THR115F, THR74E, THR74F, THR78E, THR78F, THR79E, THR79F, THR84E, THR84F, TYR108E, TYR108F, TYR301E, TYR301F, TYR87E, TYR87F, VAL73E, VAL73F, VAL81E, VAL81F, VAL82E, VAL82F
• E-G: ALA136E, ALA136G, ALA141E, ALA141G, ALA148E, ALA148G, ALA152E, ALA152G, ALA259G, ALA271E, ALA271G, ALA294E, ALA294G, ALA299E, ALA299G, ALA300E, ALA300G, ALA374E, ALA374G, ALA379E, ALA379G, ALA386E, ALA386G, ALA400E, ALA400G, ALA86E, ALA86G, ARG102E, ARG102G, ARG110E, ARG110G, ARG164E, ARG164G, ARG167E, ARG167G, ASN113E, ASN113G, ASN267E, ASN267G, ASN286E, ASN286G, ASN296E, ASN296G, ASN298E, ASN298G, ASN83E, ASN83G, ASN90E, ASN90G, ASP268E, ASP268G, ASP378E, ASP378G, ASP397E, ASP397G, ASP406E, ASP406G, ASP97E, ASP97G, CYS140E, CYS140G, GLN398E, GLN398G, GLU100E, GLU100G, GLU107E, GLU107G, GLU171E, GLU171G, GLU393E, GLU94E, GLU94G, GLY109E, GLY109G, GLY112E, GLY112G, GLY138E, GLY138G, GLY153E, GLY153G, GLY178E, GLY178G, GLY292E, GLY292G, GLY293E, GLY293G, GLY391E, GLY391G, HIS266E, HIS266G, HIS288E, HIS288G, HIS289E, HIS289G, ILE168E, ILE168G, ILE170E, ILE170G, ILE173E, ILE173G, ILE179E, ILE179G, ILE290E, ILE290G, ILE303E, ILE303G, ILE385E, ILE385G, ILE395E, ILE395G, ILE401E, ILE401G, ILE96E, ILE96G, LEU146E, LEU146G, LEU147E, LEU147G, LEU149E, LEU149G, LEU174E, LEU174G, LEU270E, LEU270G, LEU287E, LEU287G, LEU291E, LEU291G, LEU295E, LEU295G, LEU302E, LEU302G, LEU370E, LEU370G, LEU371E, LEU371G, LEU95E, LEU95G, LYS101E, LYS101G, LYS165E, LYS165G, LYS176E, LYS176G, LYS261E, LYS261G, LYS375E, LYS375G, LYS91E, LYS91G, LYS99E, LYS99G, MET135E, MET135G, MET139E, MET139G, MET177E, MET177G, MET402E, MET402G, PHE106E, PHE106G, PHE169E, PHE169G, PHE376E, PHE376G, PHE389E, PHE389G, PHE88E, PHE88G, PHE89E, PHE89G, PHE98E, PHE98G, PRO151E, PRO151G, PRO175E, PRO175G, PRO297E, PRO297G, PRO383E, PRO383G, PRO387E, PRO387G, PRO399E, PRO399G, SER105E, SER105G, SER137E, SER137G, SER142E, SER142G, SER258E, SER258G, SER388E, SER388G, SER403E, SER403G, SER85E, SER85G, SER93E, SER93G, THR143E, THR143G, THR166E, THR166G, THR172E, THR172G, THR260E, THR260G, THR373E, THR373G, THR84E, THR84G, THR92E, THR92G, TRP405E, TRP405G, TYR108E, TYR108G, TYR111E, TYR111G, TYR163E, TYR163G, TYR301E, TYR301G, TYR384E, TYR384G, TYR404E, TYR404G, TYR87E, TYR87G, VAL144E, VAL144G, VAL150E, VAL150G, VAL269E, VAL269G, VAL377E, VAL377G, VAL396E, VAL396G, VAL81E, VAL81G, VAL82E, VAL82G
• E-H: ALA299E, ALA299H, ALA386E, ALA386H, ALA436E, ALA436H, ALA51E, ALA51H, ALA61E, ALA61H, ALA76E, ALA76H, ARG305E, ARG305H, ARG313E, ARG313H, ARG67E, ARG67H, ARG70E, ARG70H, ASN267E, ASN267H, ASN298E, ASN298H, ASN55E, ASN55H, ASP268E, ASP268H, ASP430E, ASP430H, ASP432E, ASP432H, ASP433E, ASP433H, ASP437E, ASP437H, ASP57E, ASP57H, ASP75E, ASP75H, CYS392E, CYS392H, GLN315E, GLN315H, GLN316E, GLN316H, GLN317E, GLN317H, GLN440E, GLN440H, GLU393E, GLU393H, GLU429E, GLU429H, GLU66E, GLU66H, GLY264E, GLY264H, GLY265E, GLY265H, GLY306E, GLY306H, GLY391E, GLY391H, GLY427E, GLY427H, GLY58E, GLY58H, GLY69E, GLY69H, HIS266E, HIS266H, HIS311E, HIS311H, HIS63E, HIS63H, ILE303E, ILE303H, ILE304E, ILE304H, ILE382E, ILE382H, ILE385E, ILE385H, ILE395E, ILE395H, ILE62E, ILE62H, ILE77E, ILE77H, LEU263E, LEU263H, LEU302E, LEU302H, LEU310E, LEU310H, LEU312E, LEU312H, LEU380E, LEU380H, LEU434E, LEU434H, LEU54E, LEU54H, LEU68E, LEU68H, LYS122E, LYS122H, LYS308E, LYS308H, LYS381E, LYS381H, MET307E, MET307H, PHE389E, PHE389H, PHE431E, PHE431H, PHE53E, PHE53H, PRO383E, PRO383H, PRO387E, PRO387H, SER388E, SER388H, SER394E, SER394H, SER52E, SER52H, SER56E, SER56H, SER59E, SER59H, THR309E, THR309H, THR74E, THR74H, THR78E, THR78H, THR79E, THR79H, TYR301E, TYR301H, TYR384E, TYR384H, VAL269E, VAL269H, VAL314E, VAL314H, VAL396E, VAL396H, VAL428E, VAL428H, VAL60E, VAL60H, VAL81E, VAL81H
• F-G: ALA299F, ALA299G, ALA386F, ALA386G, ALA436F, ALA436G, ALA51F, ALA51G, ALA61F, ALA61G, ALA76F, ALA76G, ARG305F, ARG305G, ARG313F, ARG313G, ARG67F, ARG67G, ARG70F, ARG70G, ASN267F, ASN267G, ASN298F, ASN298G, ASN55F, ASN55G, ASP268F, ASP268G, ASP430F, ASP430G, ASP432F, ASP432G, ASP433F, ASP433G, ASP437F, ASP437G, ASP57F, ASP57G, ASP75F, ASP75G, CYS392F, CYS392G, GLN315F, GLN315G, GLN316F, GLN316G, GLN317F, GLN317G, GLN440F, GLN440G, GLU393F, GLU393G, GLU429F, GLU429G, GLU66F, GLU66G, GLY264F, GLY264G, GLY265F, GLY265G, GLY306F, GLY306G, GLY391F, GLY391G, GLY427F, GLY427G, GLY58F, GLY58G, GLY69F, GLY69G, HIS266F, HIS266G, HIS311F, HIS311G, HIS63F, HIS63G, ILE303F, ILE303G, ILE304F, ILE304G, ILE382F, ILE382G, ILE385F, ILE385G, ILE395F, ILE395G, ILE62F, ILE62G, ILE77F, ILE77G, LEU263F, LEU263G, LEU302F, LEU302G, LEU310F, LEU310G, LEU312F, LEU312G, LEU380F, LEU380G, LEU434F, LEU434G, LEU54F, LEU54G, LEU68F, LEU68G, LYS122F, LYS122G, LYS308F, LYS308G, LYS381F, LYS381G, MET307F, MET307G, PHE389F, PHE389G, PHE431F, PHE431G, PHE53F, PHE53G, PRO383F, PRO383G, PRO387F, PRO387G, SER388F, SER388G, SER394F, SER394G, SER52F, SER52G, SER56F, SER56G, SER59F, SER59G, THR309F, THR309G, THR74F, THR74G, THR78F, THR78G, THR79F, THR79G, TYR301F, TYR301G, TYR384F, TYR384G, TYR50F, TYR50G, VAL269F, VAL269G, VAL314F, VAL314G, VAL396F, VAL396G, VAL428F, VAL428G, VAL60F, VAL60G, VAL81F, VAL81G
• F-H: ALA136F, ALA136H, ALA141F, ALA141H, ALA148F, ALA148H, ALA152F, ALA152H, ALA271F, ALA271H, ALA294F, ALA294H, ALA299F, ALA299H, ALA300F, ALA300H, ALA374F, ALA374H, ALA379F, ALA379H, ALA386F, ALA386H, ALA400F, ALA400H, ALA86F, ALA86H, ARG102F, ARG102H, ARG110F, ARG110H, ARG164F, ARG164H, ARG167F, ARG167H, ASN113F, ASN113H, ASN267F, ASN267H, ASN286F, ASN286H, ASN296F, ASN296H, ASN298F, ASN298H, ASN83F, ASN83H, ASN90F, ASN90H, ASP268F, ASP268H, ASP378F, ASP378H, ASP397F, ASP397H, ASP406F, ASP406H, ASP97F, ASP97H, CYS140F, CYS140H, GLN398F, GLN398H, GLU100F, GLU100H, GLU107F, GLU107H, GLU171F, GLU94F, GLU94H, GLY109F, GLY109H, GLY112F, GLY112H, GLY138F, GLY138H, GLY153F, GLY153H, GLY154F, GLY178F, GLY178H, GLY292F, GLY292H, GLY293F, GLY293H, GLY391F, GLY391H, HIS266F, HIS266H, HIS288F, HIS288H, HIS289F, HIS289H, ILE168F, ILE168H, ILE170F, ILE170H, ILE173F, ILE173H, ILE179F, ILE179H, ILE290F, ILE290H, ILE303F, ILE303H, ILE385F, ILE385H, ILE395F, ILE395H, ILE401F, ILE401H, ILE96F, ILE96H, LEU146F, LEU146H, LEU147F, LEU147H, LEU149F, LEU149H, LEU174F, LEU174H, LEU270F, LEU270H, LEU287F, LEU287H, LEU291F, LEU291H, LEU295F, LEU295H, LEU302F, LEU302H, LEU370F, LEU370H, LEU371F, LEU371H, LEU95F, LEU95H, LYS101F, LYS101H, LYS165F, LYS165H, LYS176F, LYS176H, LYS261F, LYS261H, LYS375F, LYS375H, LYS91F, LYS91H, LYS99F, LYS99H, MET135F, MET135H, MET139F, MET139H, MET177F, MET177H, MET402F, MET402H, PHE106F, PHE106H, PHE169F, PHE169H, PHE376F, PHE376H, PHE389F, PHE389H, PHE88F, PHE88H, PHE89F, PHE89H, PHE98F, PHE98H, PRO151F, PRO151H, PRO175F, PRO175H, PRO297F, PRO297H, PRO383F, PRO383H, PRO387F, PRO387H, PRO399F, PRO399H, SER105F, SER105H, SER137F, SER137H, SER142F, SER142H, SER258F, SER258H, SER388F, SER388H, SER403F, SER403H, SER85F, SER85H, SER93F, SER93H, THR143F, THR143H, THR166F, THR166H, THR172F, THR172H, THR260F, THR260H, THR373F, THR373H, THR84F, THR84H, THR92F, THR92H, TRP405F, TRP405H, TYR108F, TYR108H, TYR111F, TYR111H, TYR163F, TYR163H, TYR301F, TYR301H, TYR384F, TYR384H, TYR404F, TYR404H, TYR87F, TYR87H, VAL144F, VAL144H, VAL150F, VAL150H, VAL269F, VAL269H, VAL377F, VAL377H, VAL396F, VAL396H, VAL422H, VAL81F, VAL81H, VAL82F, VAL82H
• G-H: ALA104G, ALA104H, ALA76G, ALA76H, ALA86G, ALA86H, ARG103G, ARG103H, ARG305G, ARG305H, ARG67G, ARG67H, ARG70G, ARG70H, ASN113G, ASN113H, ASN298G, ASN298H, ASN83G, ASN83H, ASN90G, ASN90H, ASP75G, ASP75H, GLU107G, GLU107H, GLU66G, GLU66H, GLU94G, GLU94H, GLY109G, GLY109H, GLY69G, GLY69H, GLY71G, GLY71H, ILE72G, ILE72H, ILE77G, ILE77H, PHE106G, PHE106H, PHE88G, PHE88H, PHE89G, PHE89H, PRO114G, PRO114H, PRO297G, PRO297H, PRO80G, PRO80H, SER105G, SER105H, SER85G, SER85H, THR115G, THR115H, THR74G, THR74H, THR78G, THR78H, THR79G, THR79H, THR84G, THR84H, TYR108G, TYR108H, TYR301G, TYR301H, TYR87G, TYR87H, VAL73G, VAL73H, VAL81G, VAL81H, VAL82G, VAL82H