1QDU

crystal structure of the complex of caspase-8 with the tripeptide ketone inhibitor zevd-dcbmk

• Total interactions analyzed: 153
• Total true interactions: 32
• Strongest Interaction:
  • Chains: J-X
  • Int. Res.: 22
  • Norm. En. per Res.: -7.3641
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-181.8775	-11.9295	-641.206	-835.013	165	59	13	24745	3	35	33
A-T	0.0	-55.0332	26.8363	-28.1969	27	6	0	1359	4	11	9
A-C	0.0	-4.4203	-58.2543	-62.6746	53	2	6	3373	0	8	7
A-D	-33.3694	-63.498	-126.975	-223.8424	47	25	3	4798	2	17	10
A-K	0.0	0.0	-0.0745	-0.0745	2	0	0	29	0	0	0
B-T	-45.243	-54.549	-60.9501	-160.7421	22	7	2	2035	2	6	5
B-C	-48.8505	-91.6142	-137.247	-277.7117	46	22	3	5047	8	18	9
B-D	-36.7934	2.1273	-354.597	-389.263	106	23	1	14916	0	38	32
C-D	-151.9366	-28.8376	-635.699	-816.4733	168	53	13	25159	2	35	34
C-U	-20.6258	-48.1518	4.01	-64.7676	27	5	0	1378	3	11	9
D-U	-29.7159	-55.9848	-66.3307	-152.0314	22	3	2	2045	2	7	5
E-F	-152.1593	-10.0319	-628.429	-790.6202	164	44	13	24531	3	35	33
E-V	0.0	-55.1206	-4.3304	-59.451	27	6	0	1324	3	11	9
E-G	0.0	-4.3471	-58.5012	-62.8483	54	1	6	3408	0	8	7
E-H	-33.4493	-61.5325	-130.132	-225.1138	47	21	3	4757	2	17	10
E-K	-15.177	16.5171	-51.0176	-49.6775	39	0	0	2399	0	12	5
F-V	-34.9483	-57.7267	-49.341	-142.016	21	6	2	2004	2	7	5
F-G	-50.9136	-90.0717	-137.766	-278.7512	46	26	3	5043	6	18	9
F-H	-41.503	1.9262	-348.269	-387.8458	105	29	1	14929	0	38	32
G-H	-160.2751	-28.7597	-654.128	-843.1628	168	48	12	25051	2	35	34
G-W	-20.7821	-47.2405	5.7593	-62.2633	28	11	0	1296	3	12	9
H-W	-29.2797	-52.123	-64.5165	-145.9192	24	4	2	2076	2	8	5
I-J	-151.0034	-9.7861	-632.207	-792.9965	165	51	13	24621	3	35	33
I-X	0.0	-53.9592	-23.026	-76.9852	26	5	0	1382	3	11	9
I-K	0.0	-4.4924	-57.9721	-62.4645	53	3	6	3366	0	8	7
I-L	-32.4333	-61.9675	-131.282	-225.6829	45	23	3	4763	2	16	10
J-X	-40.9369	-56.1994	-64.8747	-162.0111	22	3	2	2081	2	8	5
J-K	-43.8989	-88.9133	-132.792	-265.6042	46	27	3	5028	6	18	9
J-L	-40.657	2.2643	-348.864	-387.2567	105	24	1	14884	0	38	32
K-L	-162.972	-27.4829	-663.019	-853.4739	168	57	13	25332	2	35	34
K-Y	-22.3344	-49.065	14.4997	-56.8997	28	7	0	1380	3	12	9
L-Y	-30.0488	-58.4391	-53.6395	-142.1274	21	4	2	1998	2	6	5

Interface residues

• A-B: ALA186A, ALA188A, ALA274A, ALA284A, ALA325B, ALA332B, ALA344B, ARG162A, ARG177A, ARG179A, ARG341B, ARG358B, ARG360B, ARG395B, ASN170A, ASN180A, ASN289A, ASN335B, ASN336B, ASN342B, ASN379B, ASN381B, ASP150A, ASP178A, ASP185A, ASP228A, ASP239A, ASP288A, ASP299A, ASP323B, ASP326B, ASP365B, ASP381B, CYS229A, CYS232A, CYS233A, CYS270A, CYS285A, CYS337B, CYS354B, CYS361B, GLN154A, GLN264A, GLN283A, GLN286A, GLN291A, GLN351B, GLN355B, GLN385B, GLN388B, GLU194A, GLU195A, GLU324B, GLU345B, GLU359B, GLY181A, GLY187A, GLY238A, GLY241A, GLY267A, GLY275A, GLY287A, GLY293A, GLY330B, GLY346B, GLY363B, GLY383B, HIS171A, HIS183A, HIS197A, HIS237A, ILE167A, ILE176A, ILE231A, ILE234A, ILE242A, ILE243A, ILE258A, ILE282A, ILE294A, ILE321B, ILE350B, ILE366B, ILE369B, LEU149A, LEU184A, LEU189A, LEU196A, LEU235A, LEU261A, LEU268A, LEU273A, LEU328B, LEU329B, LEU353B, LEU357B, LEU367B, LEU370B, LEU394B, LEU398B, LYS151A, LYS156A, LYS240A, LYS269A, LYS276A, LYS278A, LYS292A, LYS381B, LYS384B, LYS396B, LYS397B, MET155A, MET331B, MET382B, MET386B, PHE173A, PHE193A, PHE198A, PHE230A, PHE265A, PHE280A, PHE281A, PHE327B, PHE392B, PHE400B, PRO277A, PRO295A, PRO322B, PRO343B, PRO362B, PRO387B, PRO389B, PRO401B, SER236A, SER263A, SER339B, SER352B, SER356B, SER378B, THR182A, THR190A, THR191A, THR192A, THR262A, THR266A, THR298A, THR333B, THR347B, THR390B, THR393B, TRP348B, TYR153A, TYR259A, TYR290A, TYR320B, TYR340B, TYR349B, TYR375B, VAL152A, VAL279A, VAL334B, VAL338B, VAL373B, VAL377B, VAL399B
• A-T: ALA284A, ARG177A, ARG179A, ASN180A, ASP178A, ASP185A, ASP239A, ASP288A, ASP4103T, CYS285A, GLN283A, GLN286A, GLN291A, GLU4101T, GLY181A, GLY238A, GLY287A, HIS237A, ILE176A, ILE243A, LEU235A, PHE173A, SER236A, THR182A, TYR244A, TYR290A, VAL4102T
• A-C: ALA274A, ALA274C, ASN289A, ASN289C, ASP299A, ASP299C, CYS270A, CYS270C, GLN154A, GLN154C, GLN291A, GLN291C, GLU297A, GLU297C, GLY267A, GLY267C, GLY275A, GLY275C, GLY293A, GLY293C, ILE294A, ILE294C, LEU268A, LEU268C, LEU273A, LEU273C, LYS151A, LYS151C, LYS269A, LYS269C, LYS276A, LYS276C, LYS278A, LYS278C, LYS292A, LYS292C, PRO271A, PRO271C, PRO295A, PRO295C, SER272C, THR266A, THR266C, THR298A, THR298C, TYR153A, TYR153C, TYR259A, TYR259C, VAL152A, VAL152C, VAL296A, VAL296C
• A-D: ALA325D, ARG319D, ARG360D, ARG362D, ARG395D, ASN335D, ASN336D, ASN374D, ASP150A, ASP299A, ASP323D, ASP326D, ASP364D, CYS337D, GLN291A, GLN388D, GLU297A, GLU324D, GLU372D, GLY293A, ILE294A, ILE321D, ILE369D, LEU149A, LEU268A, LYS151A, LYS292A, LYS396D, MET382D, MET386D, PHE327D, PRO295A, PRO322D, THR262A, THR298A, THR318D, THR368D, THR371D, THR393D, TYR153A, TYR259A, TYR290A, TYR320D, TYR375D, VAL152A, VAL296A, VAL334D
• A-K: LEU149A, LEU149K
• B-T: ALA332B, ALA344B, ARG341B, ASN342B, ASN381B, ASP381B, ASP4103T, CYS337B, GLN385B, GLU4101T, GLY346B, ILE350B, LYS384B, PRO343B, SER339B, THR333B, THR347B, TRP348B, TYR340B, TYR349B, VAL338B, VAL4102T
• B-C: ALA325B, ARG319B, ARG360B, ARG362B, ARG395B, ASN335B, ASN336B, ASN374B, ASN379B, ASP150C, ASP299C, ASP323B, ASP326B, ASP364B, CYS337B, GLN291C, GLN388B, GLU297C, GLU324B, GLU372B, GLU376B, GLY293C, ILE294C, ILE321B, ILE369B, LEU149C, LYS151C, LYS292C, LYS396B, MET386B, PHE327B, PRO295C, PRO322B, THR298C, THR318B, THR368B, THR371B, THR393B, TYR153C, TYR259C, TYR290C, TYR320B, TYR375B, VAL152C, VAL296C, VAL334B
• B-D: ALA325B, ALA325D, ARG319B, ARG319D, ARG360B, ARG360D, ARG395B, ARG395D, ASN335B, ASN335D, ASN336B, ASN336D, ASN374B, ASN374D, ASN379B, ASN379D, ASP323B, ASP323D, ASP326B, ASP326D, ASP364B, ASP364D, ASP365B, ASP365D, ASP381B, ASP381D, CYS337B, CYS337D, GLN385B, GLN385D, GLN388B, GLN388D, GLU324B, GLU324D, GLU372B, GLU372D, GLU376B, GLU376D, GLY383B, GLY383D, ILE321B, ILE321D, ILE366B, ILE366D, ILE369B, ILE369D, LEU328B, LEU328D, LEU329B, LEU329D, LEU367B, LEU367D, LEU370B, LEU370D, LEU394B, LEU394D, LEU398B, LEU398D, LYS381B, LYS381D, LYS384B, LYS384D, LYS396B, LYS396D, LYS397B, LYS397D, MET331B, MET331D, MET382B, MET382D, MET386B, MET386D, PHE327B, PHE327D, PHE392B, PHE392D, PRO322B, PRO322D, PRO387B, PRO387D, PRO389B, PRO389D, SER378B, SER378D, THR333B, THR368B, THR368D, THR371B, THR371D, THR390B, THR390D, THR393B, THR393D, TRP348B, TRP348D, TYR320B, TYR320D, TYR340D, TYR375B, TYR375D, VAL334B, VAL334D, VAL373B, VAL373D, VAL377B, VAL377D
• C-D: ALA186C, ALA188C, ALA274C, ALA284C, ALA325D, ALA332D, ALA344D, ARG162C, ARG177C, ARG179C, ARG319D, ARG341D, ARG358D, ARG360D, ARG395D, ASN169C, ASN170C, ASN180C, ASN289C, ASN335D, ASN336D, ASN342D, ASN379D, ASN381D, ASP150C, ASP178C, ASP185C, ASP228C, ASP239C, ASP288C, ASP299C, ASP323D, ASP326D, ASP365D, ASP381D, CYS229C, CYS232C, CYS233C, CYS270C, CYS285C, CYS337D, CYS354D, CYS361D, GLN154C, GLN264C, GLN283C, GLN286C, GLN291C, GLN351D, GLN355D, GLN385D, GLN388D, GLU194C, GLU195C, GLU297C, GLU324D, GLU345D, GLU359D, GLY181C, GLY187C, GLY238C, GLY241C, GLY267C, GLY275C, GLY287C, GLY293C, GLY330D, GLY346D, GLY383D, HIS171C, HIS183C, HIS197C, HIS237C, ILE167C, ILE176C, ILE231C, ILE234C, ILE242C, ILE243C, ILE258C, ILE282C, ILE294C, ILE321D, ILE350D, ILE366D, ILE369D, LEU149C, LEU184C, LEU189C, LEU196C, LEU235C, LEU261C, LEU268C, LEU273C, LEU328D, LEU329D, LEU353D, LEU357D, LEU367D, LEU370D, LEU394D, LEU398D, LYS151C, LYS156C, LYS240C, LYS269C, LYS276C, LYS278C, LYS292C, LYS381D, LYS384D, LYS396D, LYS397D, MET155C, MET331D, MET382D, MET386D, PHE173C, PHE193C, PHE198C, PHE230C, PHE265C, PHE280C, PHE281C, PHE327D, PHE392D, PHE400D, PRO271C, PRO277C, PRO295C, PRO322D, PRO343D, PRO362D, PRO387D, PRO389D, PRO401D, SER236C, SER263C, SER339D, SER352D, SER356D, SER378D, THR182C, THR190C, THR191C, THR192C, THR262C, THR266C, THR298C, THR333D, THR347D, THR390D, THR393D, TRP348D, TYR153C, TYR259C, TYR290C, TYR320D, TYR340D, TYR349D, TYR375D, VAL152C, VAL279C, VAL334D, VAL338D, VAL373D, VAL377D, VAL399D
• C-U: ALA284C, ARG177C, ARG179C, ASN170C, ASN180C, ASN289C, ASP178C, ASP185C, ASP239C, ASP288C, ASP4203U, CYS285C, GLN283C, GLN286C, GLU4201U, GLY181C, GLY238C, GLY287C, HIS237C, ILE176C, ILE243C, LEU235C, SER236C, THR182C, TYR244C, TYR290C, VAL4202U
• D-U: ALA332D, ALA344D, ARG341D, ASN342D, ASN381D, ASP381D, ASP4203U, CYS337D, GLN385D, GLU4201U, GLY346D, ILE350D, LYS381D, PRO343D, SER339D, THR333D, THR347D, TRP348D, TYR340D, TYR349D, VAL338D, VAL4202U
• E-F: ALA186E, ALA188E, ALA274E, ALA284E, ALA325F, ALA332F, ALA344F, ARG162E, ARG177E, ARG179E, ARG341F, ARG358F, ARG360F, ARG395F, ASN170E, ASN180E, ASN289E, ASN335F, ASN336F, ASN342F, ASN379F, ASN381F, ASP150E, ASP178E, ASP185E, ASP228E, ASP239E, ASP288E, ASP299E, ASP323F, ASP326F, ASP365F, ASP381F, CYS229E, CYS232E, CYS233E, CYS270E, CYS285E, CYS337F, CYS354F, CYS361F, GLN154E, GLN264E, GLN283E, GLN286E, GLN291E, GLN351F, GLN355F, GLN385F, GLN388F, GLU194E, GLU195E, GLU324F, GLU345F, GLU359F, GLY181E, GLY187E, GLY238E, GLY241E, GLY267E, GLY275E, GLY287E, GLY293E, GLY330F, GLY346F, GLY363F, GLY383F, HIS171E, HIS183E, HIS197E, HIS237E, ILE167E, ILE176E, ILE231E, ILE234E, ILE242E, ILE243E, ILE258E, ILE282E, ILE294E, ILE321F, ILE350F, ILE366F, ILE369F, LEU149E, LEU184E, LEU189E, LEU196E, LEU235E, LEU261E, LEU268E, LEU273E, LEU328F, LEU329F, LEU353F, LEU357F, LEU367F, LEU370F, LEU394F, LEU398F, LYS151E, LYS156E, LYS240E, LYS269E, LYS276E, LYS278E, LYS292E, LYS381F, LYS384F, LYS396F, LYS397F, MET155E, MET331F, MET382F, MET386F, PHE173E, PHE193E, PHE198E, PHE230E, PHE265E, PHE280E, PHE281E, PHE327F, PHE392F, PHE400F, PRO277E, PRO295E, PRO322F, PRO343F, PRO362F, PRO387F, PRO389F, PRO401F, SER236E, SER263E, SER339F, SER352F, SER356F, SER378F, THR182E, THR190E, THR191E, THR192E, THR262E, THR266E, THR298E, THR333F, THR347F, THR390F, THR393F, TRP348F, TYR153E, TYR259E, TYR290E, TYR320F, TYR340F, TYR349F, TYR375F, VAL152E, VAL279E, VAL334F, VAL338F, VAL373F, VAL399F
• E-V: ALA284E, ARG177E, ARG179E, ASN170E, ASN180E, ASP178E, ASP185E, ASP239E, ASP288E, ASP4303V, CYS285E, GLN283E, GLN286E, GLU4301V, GLY181E, GLY238E, GLY287E, HIS237E, ILE176E, ILE243E, LEU235E, PHE173E, SER236E, THR182E, TYR244E, TYR290E, VAL4302V
• E-G: ALA274E, ALA274G, ASN289E, ASN289G, ASP299E, ASP299G, CYS270E, CYS270G, GLN154E, GLN154G, GLN291E, GLN291G, GLU297E, GLU297G, GLY267E, GLY267G, GLY275E, GLY275G, GLY293E, GLY293G, ILE294E, ILE294G, LEU268E, LEU268G, LEU273E, LEU273G, LYS151E, LYS151G, LYS269E, LYS269G, LYS276E, LYS276G, LYS278E, LYS278G, LYS292E, LYS292G, PRO271E, PRO271G, PRO277G, PRO295E, PRO295G, SER272G, THR266E, THR266G, THR298E, THR298G, TYR153E, TYR153G, TYR259E, TYR259G, VAL152E, VAL152G, VAL296E, VAL296G
• E-H: ALA325H, ARG319H, ARG360H, ARG362H, ARG395H, ASN335H, ASN336H, ASN374H, ASP150E, ASP299E, ASP323H, ASP326H, ASP364H, CYS337H, GLN291E, GLN388H, GLU297E, GLU324H, GLU372H, GLY293E, ILE294E, ILE321H, ILE369H, LEU149E, LEU268E, LYS151E, LYS292E, LYS396H, MET382H, MET386H, PHE327H, PRO295E, PRO322H, THR262E, THR298E, THR318H, THR368H, THR371H, THR393H, TYR153E, TYR259E, TYR290E, TYR320H, TYR375H, VAL152E, VAL296E, VAL334H
• E-K: ASN226E, ASN226K, ASP222E, ASP222K, CYS270E, CYS270K, GLN219E, GLN219K, GLU199E, GLU199K, HIS224E, HIS224K, ILE217E, ILE217K, LEU220E, LEU220K, LEU268E, LEU268K, LEU273E, LEU273K, LYS201E, LYS201K, LYS216E, LYS216K, LYS269E, MET221E, MET221K, MET227E, MET227K, PRO271E, PRO271K, SER225E, SER225K, SER272E, SER272K, TYR164E, TYR164K, TYR218E, TYR218K
• F-V: ALA332F, ALA344F, ARG341F, ASN342F, ASN381F, ASP381F, ASP4303V, CYS337F, GLN385F, GLU4301V, GLY346F, ILE350F, PRO343F, SER339F, THR333F, THR347F, TRP348F, TYR340F, TYR349F, VAL338F, VAL4302V
• F-G: ALA325F, ARG319F, ARG360F, ARG362F, ARG395F, ASN335F, ASN336F, ASN374F, ASN379F, ASP150G, ASP299G, ASP323F, ASP326F, ASP364F, CYS337F, GLN291G, GLN388F, GLU297G, GLU324F, GLU372F, GLU376F, GLY293G, ILE294G, ILE321F, ILE369F, LEU149G, LYS151G, LYS292G, LYS396F, MET386F, PHE327F, PRO295G, PRO322F, THR298G, THR318F, THR368F, THR371F, THR393F, TYR153G, TYR259G, TYR290G, TYR320F, TYR375F, VAL152G, VAL296G, VAL334F
• F-H: ALA325F, ALA325H, ARG319F, ARG319H, ARG360F, ARG360H, ARG395F, ARG395H, ASN335F, ASN335H, ASN336F, ASN336H, ASN374F, ASN374H, ASN379F, ASN379H, ASP323F, ASP323H, ASP326F, ASP326H, ASP364F, ASP364H, ASP365F, ASP365H, ASP381F, ASP381H, CYS337F, CYS337H, GLN385F, GLN385H, GLN388F, GLN388H, GLU324F, GLU324H, GLU372F, GLU372H, GLU376F, GLU376H, GLY330H, GLY383F, GLY383H, ILE321F, ILE321H, ILE366F, ILE366H, ILE369F, ILE369H, LEU328F, LEU328H, LEU329F, LEU329H, LEU367F, LEU367H, LEU370F, LEU370H, LEU394F, LEU394H, LEU398F, LEU398H, LYS381F, LYS381H, LYS384F, LYS384H, LYS396F, LYS396H, LYS397F, LYS397H, MET331F, MET331H, MET382F, MET382H, MET386F, MET386H, PHE327F, PHE327H, PHE392F, PHE392H, PRO322F, PRO322H, PRO387F, PRO387H, PRO389F, PRO389H, SER378F, SER378H, THR368F, THR368H, THR371F, THR371H, THR390F, THR390H, THR393F, THR393H, TRP348F, TRP348H, TYR320F, TYR320H, TYR375F, TYR375H, VAL334F, VAL334H, VAL373F, VAL373H, VAL377F, VAL377H
• G-H: ALA186G, ALA188G, ALA274G, ALA284G, ALA325H, ALA332H, ALA344H, ARG162G, ARG177G, ARG179G, ARG319H, ARG341H, ARG358H, ARG360H, ARG395H, ASN169G, ASN170G, ASN180G, ASN289G, ASN335H, ASN336H, ASN342H, ASN379H, ASN381H, ASP150G, ASP178G, ASP185G, ASP228G, ASP239G, ASP288G, ASP299G, ASP323H, ASP326H, ASP365H, ASP381H, CYS229G, CYS232G, CYS233G, CYS270G, CYS285G, CYS337H, CYS354H, CYS361H, GLN154G, GLN264G, GLN283G, GLN286G, GLN291G, GLN351H, GLN355H, GLN385H, GLN388H, GLU194G, GLU195G, GLU297G, GLU324H, GLU345H, GLU359H, GLY181G, GLY187G, GLY238G, GLY241G, GLY267G, GLY275G, GLY287G, GLY293G, GLY330H, GLY346H, GLY383H, HIS171G, HIS183G, HIS197G, HIS237G, ILE167G, ILE176G, ILE231G, ILE234G, ILE242G, ILE243G, ILE258G, ILE282G, ILE294G, ILE321H, ILE350H, ILE366H, ILE369H, LEU149G, LEU184G, LEU189G, LEU196G, LEU235G, LEU261G, LEU268G, LEU273G, LEU328H, LEU329H, LEU353H, LEU357H, LEU367H, LEU370H, LEU394H, LEU398H, LYS151G, LYS156G, LYS240G, LYS269G, LYS276G, LYS278G, LYS292G, LYS381H, LYS384H, LYS396H, LYS397H, MET155G, MET331H, MET382H, MET386H, PHE173G, PHE193G, PHE198G, PHE230G, PHE265G, PHE280G, PHE281G, PHE327H, PHE392H, PHE400H, PRO277G, PRO295G, PRO322H, PRO343H, PRO362H, PRO387H, PRO389H, PRO401H, SER236G, SER263G, SER339H, SER352H, SER356H, SER378H, THR182G, THR190G, THR191G, THR192G, THR262G, THR266G, THR298G, THR333H, THR347H, THR390H, THR393H, TRP348H, TYR153G, TYR259G, TYR290G, TYR320H, TYR340H, TYR349H, TYR375H, VAL152G, VAL279G, VAL296G, VAL334H, VAL338H, VAL373H, VAL377H, VAL399H
• G-W: ALA284G, ARG177G, ARG179G, ASN170G, ASN180G, ASN289G, ASP178G, ASP185G, ASP239G, ASP288G, ASP4403W, CYS285G, GLN283G, GLN286G, GLU4401W, GLY181G, GLY238G, GLY287G, HIS237G, ILE176G, ILE243G, LEU235G, PHE173G, SER236G, THR182G, TYR244G, TYR290G, VAL4402W
• H-W: ALA332H, ALA344H, ARG341H, ASN342H, ASN381H, ASP381H, ASP4403W, CYS337H, GLN385H, GLU4401W, GLY346H, GLY383H, ILE350H, LYS381H, LYS384H, PRO343H, SER339H, THR333H, THR347H, TRP348H, TYR340H, TYR349H, VAL338H, VAL4402W
• I-J: ALA186I, ALA188I, ALA274I, ALA284I, ALA325J, ALA332J, ALA344J, ARG162I, ARG177I, ARG179I, ARG341J, ARG358J, ARG360J, ARG395J, ASN170I, ASN180I, ASN289I, ASN335J, ASN336J, ASN342J, ASN379J, ASN381J, ASP150I, ASP178I, ASP185I, ASP228I, ASP239I, ASP288I, ASP299I, ASP323J, ASP326J, ASP365J, ASP381J, CYS229I, CYS232I, CYS233I, CYS270I, CYS285I, CYS337J, CYS354J, CYS361J, GLN154I, GLN264I, GLN283I, GLN286I, GLN291I, GLN351J, GLN355J, GLN385J, GLN388J, GLU194I, GLU195I, GLU297I, GLU324J, GLU345J, GLU359J, GLY181I, GLY187I, GLY238I, GLY241I, GLY267I, GLY275I, GLY287I, GLY293I, GLY330J, GLY346J, GLY383J, HIS171I, HIS183I, HIS197I, HIS237I, ILE167I, ILE176I, ILE231I, ILE234I, ILE242I, ILE243I, ILE258I, ILE282I, ILE294I, ILE321J, ILE350J, ILE366J, ILE369J, LEU149I, LEU184I, LEU189I, LEU196I, LEU235I, LEU261I, LEU268I, LEU273I, LEU328J, LEU329J, LEU353J, LEU357J, LEU367J, LEU370J, LEU394J, LEU398J, LYS151I, LYS156I, LYS240I, LYS269I, LYS276I, LYS278I, LYS292I, LYS381J, LYS384J, LYS396J, LYS397J, MET155I, MET331J, MET382J, MET386J, PHE173I, PHE193I, PHE198I, PHE230I, PHE265I, PHE280I, PHE281I, PHE327J, PHE392J, PHE400J, PRO277I, PRO295I, PRO322J, PRO343J, PRO362J, PRO387J, PRO389J, PRO401J, SER236I, SER263I, SER339J, SER352J, SER356J, SER378J, THR182I, THR190I, THR191I, THR192I, THR262I, THR266I, THR298I, THR333J, THR347J, THR390J, THR393J, TRP348J, TYR153I, TYR259I, TYR290I, TYR320J, TYR340J, TYR349J, TYR375J, VAL152I, VAL279I, VAL334J, VAL338J, VAL373J, VAL377J, VAL399J
• I-X: ALA284I, ARG177I, ARG179I, ASN180I, ASP178I, ASP185I, ASP239I, ASP288I, ASP4503X, CYS285I, GLN283I, GLN286I, GLU4501X, GLY181I, GLY238I, GLY287I, HIS237I, ILE176I, ILE243I, LEU235I, PHE173I, SER236I, THR182I, TYR244I, TYR290I, VAL4502X
• I-K: ALA274I, ALA274K, ASN289I, ASN289K, ASP299I, ASP299K, CYS270I, CYS270K, GLN154I, GLN154K, GLN291I, GLN291K, GLU297I, GLU297K, GLY267I, GLY267K, GLY275I, GLY275K, GLY293I, GLY293K, ILE294I, ILE294K, LEU268I, LEU268K, LEU273I, LEU273K, LYS151I, LYS151K, LYS269I, LYS269K, LYS276I, LYS276K, LYS278I, LYS278K, LYS292I, LYS292K, PRO271I, PRO271K, PRO295I, PRO295K, SER272K, THR266I, THR266K, THR298I, THR298K, TYR153I, TYR153K, TYR259I, TYR259K, VAL152I, VAL152K, VAL296I, VAL296K
• I-L: ALA325L, ARG319L, ARG360L, ARG362L, ARG395L, ASN335L, ASN336L, ASN374L, ASP150I, ASP299I, ASP323L, ASP326L, ASP364L, CYS337L, GLN291I, GLN388L, GLU297I, GLU324L, GLU372L, GLY293I, ILE294I, ILE321L, LEU149I, LEU268I, LYS151I, LYS292I, LYS396L, MET382L, PHE327L, PRO295I, PRO322L, THR262I, THR298I, THR318L, THR368L, THR371L, THR393L, TYR153I, TYR259I, TYR290I, TYR320L, TYR375L, VAL152I, VAL296I, VAL334L
• J-X: ALA332J, ALA344J, ARG341J, ASN342J, ASN381J, ASP381J, ASP4503X, CYS337J, GLN385J, GLU4501X, GLY346J, ILE350J, LYS384J, PRO343J, SER339J, THR333J, THR347J, TRP348J, TYR340J, TYR349J, VAL338J, VAL4502X
• J-K: ALA325J, ARG319J, ARG360J, ARG362J, ARG395J, ASN335J, ASN336J, ASN374J, ASN379J, ASP150K, ASP299K, ASP323J, ASP326J, ASP364J, CYS337J, GLN291K, GLN388J, GLU297K, GLU324J, GLU372J, GLU376J, GLY293K, ILE294K, ILE321J, ILE369J, LEU149K, LYS151K, LYS292K, LYS396J, MET386J, PHE327J, PRO295K, PRO322J, THR298K, THR318J, THR368J, THR371J, THR393J, TYR153K, TYR259K, TYR290K, TYR320J, TYR375J, VAL152K, VAL296K, VAL334J
• J-L: ALA325J, ALA325L, ARG319J, ARG319L, ARG360J, ARG360L, ARG395J, ARG395L, ASN335J, ASN335L, ASN336J, ASN336L, ASN374J, ASN374L, ASN379J, ASN379L, ASP323J, ASP323L, ASP326J, ASP326L, ASP364J, ASP364L, ASP365J, ASP365L, ASP381J, ASP381L, CYS337J, CYS337L, GLN385J, GLN385L, GLN388J, GLN388L, GLU324J, GLU324L, GLU372J, GLU372L, GLU376J, GLU376L, GLY383J, GLY383L, ILE321J, ILE321L, ILE366J, ILE366L, ILE369J, ILE369L, LEU328J, LEU328L, LEU329J, LEU329L, LEU367J, LEU367L, LEU370J, LEU370L, LEU394J, LEU394L, LEU398J, LEU398L, LYS381J, LYS381L, LYS384J, LYS384L, LYS396J, LYS396L, LYS397J, LYS397L, MET331J, MET331L, MET382J, MET382L, MET386J, MET386L, PHE327J, PHE327L, PHE392J, PHE392L, PRO322J, PRO322L, PRO387J, PRO387L, PRO389J, PRO389L, SER378J, SER378L, THR333J, THR368J, THR368L, THR371J, THR371L, THR390J, THR390L, THR393J, THR393L, TRP348J, TRP348L, TYR320J, TYR320L, TYR375J, TYR375L, VAL334J, VAL334L, VAL373J, VAL373L, VAL377J, VAL377L
• K-L: ALA186K, ALA188K, ALA274K, ALA284K, ALA325L, ALA332L, ALA344L, ARG162K, ARG177K, ARG179K, ARG319L, ARG341L, ARG358L, ARG360L, ARG395L, ASN169K, ASN170K, ASN180K, ASN289K, ASN335L, ASN336L, ASN342L, ASN379L, ASN381L, ASP150K, ASP178K, ASP185K, ASP228K, ASP239K, ASP288K, ASP299K, ASP323L, ASP326L, ASP365L, ASP381L, CYS165K, CYS229K, CYS232K, CYS233K, CYS270K, CYS285K, CYS337L, CYS354L, CYS361L, GLN154K, GLN264K, GLN283K, GLN286K, GLN291K, GLN351L, GLN355L, GLN385L, GLN388L, GLU194K, GLU195K, GLU297K, GLU324L, GLU345L, GLU359L, GLY181K, GLY187K, GLY238K, GLY241K, GLY267K, GLY275K, GLY287K, GLY293K, GLY330L, GLY346L, GLY383L, HIS171K, HIS183K, HIS197K, HIS237K, ILE167K, ILE176K, ILE231K, ILE234K, ILE242K, ILE243K, ILE258K, ILE282K, ILE294K, ILE321L, ILE350L, ILE366L, ILE369L, LEU149K, LEU184K, LEU189K, LEU196K, LEU235K, LEU261K, LEU268K, LEU273K, LEU328L, LEU329L, LEU353L, LEU357L, LEU367L, LEU370L, LEU394L, LEU398L, LYS151K, LYS156K, LYS240K, LYS269K, LYS276K, LYS278K, LYS292K, LYS381L, LYS384L, LYS396L, LYS397L, MET155K, MET331L, MET382L, MET386L, PHE173K, PHE193K, PHE198K, PHE230K, PHE265K, PHE280K, PHE281K, PHE327L, PHE392L, PHE400L, PRO271K, PRO277K, PRO295K, PRO322L, PRO343L, PRO362L, PRO387L, PRO389L, PRO401L, SER236K, SER263K, SER339L, SER352L, SER356L, SER378L, THR182K, THR190K, THR191K, THR192K, THR262K, THR266K, THR298K, THR333L, THR347L, THR390L, THR393L, TRP348L, TYR153K, TYR259K, TYR290K, TYR320L, TYR340L, TYR349L, TYR375L, VAL152K, VAL279K, VAL334L, VAL338L, VAL373L, VAL399L
• K-Y: ALA284K, ARG177K, ARG179K, ASN170K, ASN180K, ASN289K, ASP178K, ASP185K, ASP239K, ASP288K, ASP4603Y, CYS285K, GLN283K, GLN286K, GLU4601Y, GLY181K, GLY238K, GLY287K, HIS237K, ILE176K, ILE243K, LEU235K, PHE173K, SER236K, THR182K, TYR244K, TYR290K, VAL4602Y
• L-Y: ALA332L, ALA344L, ARG341L, ASN342L, ASN381L, ASP381L, ASP4603Y, CYS337L, GLN385L, GLU4601Y, GLY346L, ILE350L, LYS381L, PRO343L, SER339L, THR333L, THR347L, TRP348L, TYR340L, VAL338L, VAL4602Y