1QAB

the structure of human retinol binding protein with its carrier protein transthyretin reveals interaction with the carboxy terminus of rbp

• Total interactions analyzed: 15
• Total true interactions: 13
• Strongest Interaction:
  • Chains: A-D
  • Int. Res.: 41
  • Norm. En. per Res.: -2.9894
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-40.1321	9.5533	-217.747	-248.3258	90	31	6	9516	0	29	27
A-C	-7.5707	0.0	-61.65	-69.2207	49	1	2	3193	0	4	4
A-D	-19.2437	0.0	-103.321	-122.5647	41	11	5	4149	0	1	2
A-E	0.0	0.0	-62.0786	-62.0786	31	3	1	2787	0	4	2
A-F	0.0	-7.6926	-24.8036	-32.4962	24	5	0	1445	0	4	3
B-C	-8.6869	0.0	-82.4035	-91.0904	40	13	5	3823	0	0	2
B-D	-8.4161	0.0	-70.85	-79.2661	58	11	1	3757	0	8	5
B-E	0.0	0.0	-0.0913	-0.0913	4	0	0	20	0	0	0
B-F	-10.2997	0.0	-35.6896	-45.9893	43	24	5	3989	0	3	6
C-D	-44.5347	21.6755	-183.212	-206.0713	90	27	7	9726	1	29	28
C-E	0.0	-11.2747	-18.4804	-29.7551	21	3	0	1053	0	4	1
C-F	0.0	0.0	-23.7782	-23.7782	26	3	1	1955	0	2	1
D-E	-5.767	0.0	-42.1567	-47.9237	41	18	4	4429	0	3	6

Interface residues

• A-B: ALA108A, ALA108B, ALA109A, ALA109B, ALA120A, ALA120B, ALA91A, ALA91B, ALA97A, ALA97B, ARG103A, ARG104B, ASN124B, ASN98A, ASN98B, GLU72A, GLU72B, GLU89A, GLU89B, GLU92A, GLU92B, GLY67A, GLY67B, HIS88A, HIS88B, HIS90A, HIS90B, ILE107A, ILE107B, ILE68A, ILE68B, LEU110A, LEU110B, LEU12A, LEU12B, LYS35A, LYS35B, LYS70A, LYS70B, LYS76A, LYS76B, PHE64B, PHE87A, PHE87B, PHE95A, PHE95B, PRO102B, PRO113A, PRO113B, PRO86A, PRO86B, SER100B, SER112A, SER112B, SER115A, SER115B, SER117A, SER117B, SER85A, THR106A, THR106B, THR118A, THR118B, THR119A, THR119B, THR123A, THR123B, THR40B, THR96A, THR96B, TRP41A, TRP41B, TYR105A, TYR105B, TYR114A, TYR114B, TYR116A, TYR116B, TYR69A, TYR69B, VAL121A, VAL121B, VAL122A, VAL122B, VAL71A, VAL71B, VAL93A, VAL93B, VAL94A, VAL94B
• A-C: ALA108A, ALA108C, ALA120A, ALA120C, ALA19A, ALA19C, ALA25A, ALA25C, ARG21A, ARG21C, ASN124A, ASP18A, ASP18C, GLU51C, GLU54C, GLY22A, GLY22C, GLY53C, LEU110A, LEU110C, LEU111A, LEU17A, LEU17C, LYS15A, LYS15C, MET13C, PRO24A, PRO24C, SER117A, SER117C, SER23A, SER23C, SER52A, SER52C, THR106A, THR106C, THR118A, THR118C, THR119A, THR119C, THR123A, THR123C, VAL121A, VAL121C, VAL122A, VAL122C, VAL16A, VAL16C, VAL20C
• A-D: ALA19A, ALA19D, ARG21A, ARG21D, ASP18A, ASP18D, GLY22A, GLY22D, HIS88A, ILE84A, ILE84D, LEU110A, LEU110D, LEU111A, LEU111D, LEU17A, LEU17D, PHE87A, PHE87D, PRO113A, PRO113D, PRO86A, PRO86D, SER112A, SER112D, SER115A, SER115D, SER117A, SER117D, SER23A, SER23D, SER85A, SER85D, TRP79A, TRP79D, TYR114A, TYR114D, TYR116A, TYR116D, VAL20A, VAL20D
• A-E: ALA19A, ALA81A, ALA94E, ARG21A, ASN181E, ASN65E, ASN66E, ASP18A, ASP68E, CYS70E, GLU179E, GLY22A, GLY83A, ILE84A, LEU182E, LEU183E, LEU63E, LEU64E, LEU82A, LYS80A, PHE96E, PRO113A, SER23A, SER85A, SER95E, TRP67E, TRP79A, TYR114A, TYR78A, VAL20A, VAL69E
• A-F: ALA94F, ARG103A, ASN101F, ASN124A, ASN98A, ASP99A, GLU66A, GLY100F, GLY101A, GLY75F, GLY92F, LYS89F, LYS99F, PHE96F, PRO102A, SER100A, SER95F, THR123A, THR96A, TRP91F, TYR90F, VAL122A, VAL74F, VAL93F
• B-C: ALA19B, ALA19C, ARG21B, ARG21C, ASP18B, ASP18C, GLY22B, GLY22C, HIS88C, ILE84B, ILE84C, LEU110B, LEU110C, LEU111B, LEU111C, LEU17B, PHE87B, PHE87C, PRO113B, PRO113C, PRO86B, PRO86C, SER112B, SER112C, SER115B, SER115C, SER117B, SER117C, SER23B, SER23C, SER85B, SER85C, TRP79B, TRP79C, TYR114B, TYR114C, TYR116B, TYR116C, VAL20B, VAL20C
• B-D: ALA108B, ALA108D, ALA109B, ALA109D, ALA120B, ALA120D, ALA19B, ALA19D, ALA25B, ALA25D, ARG104D, ARG21B, ARG21D, ASN124B, ASP18B, ASP18D, GLU51D, GLY22B, GLY22D, GLY53B, GLY53D, ILE26D, LEU110B, LEU110D, LEU111B, LEU111D, LEU17B, LEU17D, LYS15B, LYS15D, MET13B, MET13D, PRO102D, PRO125B, PRO24B, PRO24D, SER117B, SER117D, SER23B, SER23D, SER52B, SER52D, THR106B, THR106D, THR118B, THR118D, THR119B, THR119D, THR123B, TYR105D, VAL121B, VAL121D, VAL122B, VAL122D, VAL16B, VAL16D, VAL20B, VAL20D
• B-E: ASN124B, ASN65E, ASN66E, THR123B
• B-F: ALA19B, ALA81B, ALA94F, ARG21B, ARG62F, ASN65F, ASN66F, ASP18B, GLN98F, GLU89B, GLY100F, GLY22B, GLY34F, GLY83B, GLY92F, HIS88B, ILE84B, LEU35F, LEU63F, LEU64F, LEU82B, LEU97F, LYS76B, LYS80B, LYS99F, MET73F, PHE36F, PHE87B, PHE96F, PRO113B, PRO86B, SER112B, SER23B, SER85B, SER95F, TRP67F, TRP79B, TRP91F, TYR114B, TYR78B, VAL20B, VAL61F, VAL69F
• C-D: ALA108C, ALA108D, ALA120C, ALA120D, ALA91C, ALA91D, ALA97C, ALA97D, ARG103C, ARG103D, ARG104D, ASN98C, ASN98D, ASP99C, GLU72C, GLU72D, GLU89C, GLU89D, GLU92C, GLU92D, GLY67C, GLY67D, HIS88C, HIS88D, HIS90C, HIS90D, ILE107C, ILE107D, ILE68C, ILE68D, LEU110C, LEU110D, LEU12C, LEU12D, LYS35C, LYS35D, LYS70C, LYS70D, LYS76C, LYS76D, LYS80C, PHE64C, PHE64D, PHE87C, PHE87D, PHE95C, PHE95D, PRO102D, PRO113C, PRO113D, PRO86C, PRO86D, SER100D, SER112C, SER112D, SER115C, SER115D, SER117C, SER117D, SER85C, THR106C, THR106D, THR118C, THR118D, THR119C, THR119D, THR75C, THR75D, THR96C, THR96D, TRP41C, TRP41D, TYR105C, TYR105D, TYR114C, TYR114D, TYR116C, TYR116D, TYR69C, TYR69D, VAL121C, VAL121D, VAL122C, VAL122D, VAL71C, VAL71D, VAL93C, VAL93D, VAL94C, VAL94D
• C-E: ALA94E, ARG103C, ASN98C, ASP99C, GLU66C, GLY100E, GLY101C, GLY75E, GLY92E, LYS89E, LYS99E, PHE96E, SER100C, SER95E, THR76E, THR96C, TRP91E, TYR90E, VAL122C, VAL74E, VAL93E
• C-F: ALA94F, ARG21C, ASN65F, ASN66F, ASP18C, ASP68F, CYS70F, GLY22C, GLY83C, ILE84C, LEU63F, LEU64F, LEU82C, LEU97F, PHE96F, PRO113C, PRO86C, SER23C, SER85C, SER95F, TRP67F, TRP79C, TYR114C, TYR173F, VAL20C, VAL69F
• D-E: ALA19D, ALA81D, ALA94E, ARG21D, ARG62E, ASN65E, ASN66E, ASP18D, GLN98E, GLU89D, GLY100E, GLY22D, GLY34E, GLY83D, GLY92E, HIS88D, ILE84D, LEU35E, LEU63E, LEU64E, LEU82D, LEU97E, LYS76D, LYS80D, LYS99E, PHE36E, PHE87D, PHE96E, PRO113D, PRO86D, SER23D, SER85D, SER95E, TRP67E, TRP79D, TRP91E, TYR114D, TYR90E, VAL20D, VAL61E, VAL69E