1Q5R

the rhodococcus 20s proteasome with unprocessed pro-peptides

• Total interactions analyzed: 91
• Total true interactions: 28
• Strongest Interaction:
  • Chains: B-J
  • Int. Res.: 64
  • Norm. En. per Res.: -4.1281
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-5.8656	10.0423	-142.277	-138.1003	79	15	3	6596	1	19	24
A-G	-16.0687	10.8023	-133.535	-138.8014	78	9	3	6379	1	19	23
A-H	-19.385	-27.0196	-229.373	-275.7776	99	15	6	10148	7	39	42
A-I	-31.4407	-74.552	-154.008	-260.0008	65	9	1	5984	5	31	29
B-C	-13.6594	10.5056	-141.423	-144.5768	79	10	3	6647	1	20	24
B-I	-18.8819	-27.6473	-220.584	-267.1132	98	17	6	9919	7	37	42
B-J	-26.3302	-76.2512	-161.62	-264.2014	64	5	1	6053	5	34	29
C-D	-13.4759	10.5356	-139.714	-142.6543	78	9	3	6488	1	19	23
C-J	-18.4328	-12.6576	-225.014	-256.1044	99	18	6	10166	9	38	42
C-K	-22.5813	-70.4953	-151.984	-245.0606	64	6	1	5914	4	30	29
D-E	-10.8882	8.9727	-141.876	-143.7915	78	5	3	6418	1	19	24
D-K	-19.3183	-13.2305	-225.389	-257.9379	99	14	6	10024	9	39	42
D-L	-27.4951	-72.8584	-153.123	-253.4765	65	9	1	5943	5	30	29
E-F	-5.2443	10.7043	-133.947	-128.4869	79	7	3	6207	1	19	23
E-L	-21.4073	-14.2424	-229.239	-264.8887	98	14	6	10027	9	39	42
E-M	-26.3056	-70.5408	-148.387	-245.2335	65	5	1	5725	5	29	28
F-G	-5.371	10.3285	-134.387	-129.4295	78	6	3	6208	1	19	23
F-M	-17.6051	-13.7168	-230.817	-262.139	99	14	6	10099	9	39	42
F-N	-23.4133	-74.0758	-154.157	-251.6461	65	5	1	5884	5	30	29
G-H	-24.1272	-73.7275	-154.042	-251.8967	65	7	1	6012	5	31	29
G-N	-17.9362	-13.7352	-231.649	-263.3204	99	14	6	10038	9	39	42
H-I	-16.0336	-11.3051	-121.221	-148.5597	86	3	5	6318	1	26	27
H-N	-16.3504	-11.7951	-124.772	-152.9175	86	3	5	6428	1	27	27
I-J	-6.2831	-10.991	-115.978	-133.2521	86	2	5	6130	1	26	25
J-K	-24.1563	-11.7734	-127.903	-163.8327	88	4	5	6586	1	27	27
K-L	-11.5942	-11.4842	-117.602	-140.6804	85	2	5	6153	1	27	27
L-M	-6.1185	-11.6723	-113.849	-131.6398	85	1	5	6029	1	26	25
M-N	-12.2669	-11.1059	-118.532	-141.9048	86	2	5	6241	1	26	27

Interface residues

• A-B: ALA100A, ALA102A, ALA104A, ALA20B, ALA49B, ALA77B, ALA9A, ARG140A, ARG14A, ARG14B, ARG16A, ARG16B, ARG222B, ARG26B, ARG75B, ARG76B, ARG85A, ARG97A, ASN101A, ASN45B, ASN69B, ASN73B, ASP144A, ASP149A, ASP15B, GLN105A, GLN114A, GLN114B, GLN11A, GLN137A, GLN151A, GLU10A, GLU113A, GLU119B, GLU150A, GLU18B, GLU70B, GLU72B, GLY108A, GLY145A, GLY23B, HIS51B, HIS81A, ILE110A, ILE110B, ILE12A, ILE12B, ILE141A, ILE147A, LEU107A, LEU138A, LEU19B, LEU50B, LEU74B, LYS116B, LYS134A, LYS22B, LYS67B, MET13A, MET13B, PHE111A, PRO115B, PRO117B, PRO46B, SER146A, SER17B, SER47B, SER98A, THR106A, THR109A, THR112A, THR142A, THR48B, TYR103A, TYR118B, TYR139A, TYR143A, TYR68B, VAL148A
• A-G: ALA100G, ALA102G, ALA104G, ALA20A, ALA49A, ALA77A, ALA9G, ARG140G, ARG14A, ARG14G, ARG16A, ARG16G, ARG222A, ARG26A, ARG75A, ARG76A, ARG85G, ARG97G, ASN101G, ASN45A, ASN69A, ASN73A, ASP144G, ASP149G, ASP15A, GLN105G, GLN114A, GLN114G, GLN11G, GLN137G, GLN151G, GLU10G, GLU113G, GLU119A, GLU150G, GLU18A, GLU70A, GLU72A, GLY108G, GLY145G, GLY23A, HIS51A, HIS81G, ILE110A, ILE110G, ILE12A, ILE12G, ILE141G, ILE147G, LEU107G, LEU138G, LEU19A, LEU50A, LEU74A, LYS116A, LYS134G, LYS22A, LYS67A, MET13G, PHE111G, PRO115A, PRO117A, PRO46A, SER146G, SER17A, SER47A, SER98G, THR106G, THR109G, THR112G, THR142G, THR48A, TYR103G, TYR118A, TYR139G, TYR143G, TYR68A, VAL148G
• A-H: ALA-32H, ALA100A, ALA102A, ALA104A, ALA202H, ALA49A, ALA60H, ALA77A, ALA82A, ARG215A, ARG217A, ARG218A, ARG222A, ARG57H, ARG75A, ARG76A, ARG85A, ARG91A, ARG92A, ASN-44H, ASN101A, ASN69A, ASN73A, ASP38H, ASP58A, ASP83A, ASP90A, GLN105A, GLN114A, GLU-30H, GLU39H, GLU54H, GLU55A, GLU62H, GLU64H, GLU67H, GLU70A, GLU70H, GLU72A, GLY-46H, GLY71H, GLY78A, GLY86A, HIS-33H, HIS204H, HIS51A, HIS65H, HIS81A, ILE110A, ILE122A, ILE53H, ILE69H, ILE79A, LEU-28H, LEU-29H, LEU-36H, LEU-43H, LEU-49H, LEU107A, LEU55H, LEU56A, LEU58H, LEU60A, LEU63H, LEU74A, LEU99A, LYS68H, MET84A, PHE-40H, PHE-47H, PHE220A, PHE59H, PHE71A, PRO-27H, PRO73H, SER-41H, SER-42H, SER-45H, SER-48H, SER54A, SER88A, SER98A, THR106A, THR109A, THR37H, TYR-37H, TYR103A, TYR118A, TYR57A, TYR66H, TYR87A, TYR89A, VAL203H, VAL36H, VAL56H, VAL61H, VAL72H, VAL80A, VAL94A
• A-I: ALA102A, ALA111I, ALA80I, ALA84I, ARG119I, ARG129A, ARG129I, ARG82I, ARG85A, ARG88I, ARG91A, ARG92A, ARG97A, ASN-44I, ASN101A, ASN81I, ASP-38I, ASP108I, ASP110I, ASP112I, ASP77I, ASP83A, ASP90A, ASP93A, GLN105A, GLU62I, GLU67I, GLU70I, GLY-46I, GLY131A, GLY71I, GLY78I, GLY86A, HIS65I, HIS81A, ILE69I, LEU-43I, LEU109I, LEU63I, LEU74I, LEU83I, LEU99A, LYS79I, MET84A, MET86I, PHE-40I, PHE-47I, PHE76I, PRO73I, SER-41I, SER-42I, SER-45I, SER85I, SER88A, SER98A, THR-39I, THR106A, THR75I, THR95A, TYR66I, TYR87A, TYR89A, VAL72I, VAL80A, VAL94A
• B-C: ALA100B, ALA102B, ALA104B, ALA20C, ALA49C, ALA77C, ALA9B, ARG140B, ARG14B, ARG14C, ARG16B, ARG16C, ARG222C, ARG26C, ARG75C, ARG76C, ARG85B, ARG97B, ASN101B, ASN45C, ASN69C, ASN73C, ASP144B, ASP149B, ASP15C, GLN105B, GLN114B, GLN114C, GLN11B, GLN137B, GLN151B, GLU10B, GLU113B, GLU119C, GLU150B, GLU18C, GLU70C, GLU72C, GLY108B, GLY145B, GLY23C, HIS51C, HIS81B, ILE110B, ILE110C, ILE12B, ILE12C, ILE141B, ILE147B, LEU107B, LEU138B, LEU19C, LEU50C, LEU74C, LEU99B, LYS116C, LYS134B, LYS22C, LYS67C, MET13B, PHE111B, PRO115C, PRO117C, PRO46C, SER146B, SER17C, SER47C, SER98B, THR106B, THR109B, THR112B, THR142B, THR48C, TYR103B, TYR118C, TYR139B, TYR143B, TYR68C, VAL148B
• B-I: ALA-32I, ALA100B, ALA102B, ALA104B, ALA202I, ALA49B, ALA60I, ALA77B, ALA82B, ARG217B, ARG218B, ARG222B, ARG57I, ARG75B, ARG76B, ARG85B, ARG91B, ARG92B, ASN-44I, ASN101B, ASN69B, ASN73B, ASP38I, ASP58B, ASP83B, ASP90B, GLN105B, GLN114B, GLU-30I, GLU39I, GLU54I, GLU55B, GLU62I, GLU64I, GLU67I, GLU70B, GLU70I, GLU72B, GLY-46I, GLY71I, GLY78B, GLY86B, HIS-33I, HIS204I, HIS51B, HIS65I, HIS81B, ILE110B, ILE122B, ILE53I, ILE69I, ILE79B, LEU-28I, LEU-29I, LEU-36I, LEU-43I, LEU-49I, LEU107B, LEU55I, LEU56B, LEU58I, LEU63I, LEU74B, LEU99B, LYS68I, MET84B, PHE-40I, PHE-47I, PHE220B, PHE59I, PHE71B, PRO-27I, PRO73I, SER-41I, SER-42I, SER-45I, SER-48I, SER54B, SER88B, SER98B, THR-39I, THR106B, THR109B, THR37I, TYR-37I, TYR103B, TYR118B, TYR57B, TYR66I, TYR87B, TYR89B, VAL203I, VAL36I, VAL56I, VAL61I, VAL72I, VAL80B, VAL94B
• B-J: ALA102B, ALA111J, ALA80J, ARG119J, ARG129B, ARG129J, ARG82J, ARG85B, ARG88J, ARG91B, ARG92B, ARG97B, ASN-44J, ASN101B, ASN81J, ASP-38J, ASP108J, ASP110J, ASP112J, ASP77J, ASP83B, ASP90B, ASP93B, GLN105B, GLU62J, GLU67J, GLU70J, GLY-46J, GLY131B, GLY71J, GLY78J, GLY86B, HIS65J, HIS81B, ILE69J, LEU-43J, LEU109J, LEU63J, LEU74J, LEU83J, LEU99B, LYS79J, MET84B, MET86J, PHE-40J, PHE-47J, PHE76J, PRO73J, SER-41J, SER-42J, SER-45J, SER85J, SER88B, SER98B, THR-39J, THR106B, THR75J, THR95B, TYR66J, TYR87B, TYR89B, VAL72J, VAL80B, VAL94B
• C-D: ALA100C, ALA102C, ALA104C, ALA20D, ALA49D, ALA77D, ALA9C, ARG140C, ARG14C, ARG14D, ARG16C, ARG16D, ARG222D, ARG26D, ARG75D, ARG76D, ARG85C, ARG97C, ASN101C, ASN45D, ASN69D, ASN73D, ASP144C, ASP149C, ASP15D, GLN105C, GLN114C, GLN114D, GLN11C, GLN137C, GLN151C, GLU10C, GLU113C, GLU119D, GLU18D, GLU70D, GLU72D, GLY108C, GLY145C, GLY23D, HIS51D, HIS81C, ILE110C, ILE110D, ILE12C, ILE12D, ILE141C, ILE147C, LEU107C, LEU138C, LEU19D, LEU50D, LEU74D, LYS116D, LYS134C, LYS22D, LYS67D, MET13C, MET13D, PHE111C, PRO115D, PRO117D, PRO46D, SER146C, SER17D, SER47D, SER98C, THR106C, THR109C, THR112C, THR142C, THR48D, TYR103C, TYR118D, TYR139C, TYR143C, TYR68D, VAL148C
• C-J: ALA-32J, ALA100C, ALA102C, ALA104C, ALA202J, ALA49C, ALA60J, ALA77C, ALA82C, ARG215C, ARG217C, ARG218C, ARG222C, ARG57J, ARG75C, ARG76C, ARG85C, ARG91C, ARG92C, ASN-44J, ASN101C, ASN69C, ASN73C, ASP38J, ASP58C, ASP83C, ASP90C, GLN105C, GLN114C, GLU-30J, GLU39J, GLU54J, GLU55C, GLU62J, GLU64J, GLU67J, GLU70C, GLU70J, GLU72C, GLY-46J, GLY71J, GLY78C, GLY86C, HIS-33J, HIS204J, HIS51C, HIS65J, HIS81C, ILE110C, ILE122C, ILE53J, ILE69J, ILE79C, LEU-28J, LEU-29J, LEU-36J, LEU-43J, LEU-49J, LEU107C, LEU55J, LEU56C, LEU58J, LEU60C, LEU63J, LEU74C, LEU99C, LYS68J, MET84C, PHE-40J, PHE-47J, PHE220C, PHE59J, PHE71C, PRO-27J, PRO73J, SER-41J, SER-42J, SER-45J, SER-48J, SER54C, SER88C, SER98C, THR106C, THR109C, THR37J, TYR-37J, TYR103C, TYR118C, TYR57C, TYR66J, TYR87C, TYR89C, VAL203J, VAL36J, VAL56J, VAL61J, VAL72J, VAL80C, VAL94C
• C-K: ALA102C, ALA111K, ALA80K, ALA82C, ARG119K, ARG129C, ARG129K, ARG82K, ARG85C, ARG88K, ARG91C, ARG92C, ARG97C, ASN-44K, ASN101C, ASN81K, ASP-38K, ASP108K, ASP110K, ASP112K, ASP77K, ASP83C, ASP90C, ASP93C, GLN105C, GLU62K, GLU67K, GLU70K, GLY-46K, GLY71K, GLY78K, GLY86C, HIS65K, HIS81C, ILE69K, LEU-43K, LEU109K, LEU63K, LEU74K, LEU83K, LEU99C, LYS79K, MET84C, MET86K, PHE-40K, PHE-47K, PHE76K, PRO73K, SER-41K, SER-42K, SER-45K, SER85K, SER88C, SER98C, THR-39K, THR106C, THR75K, THR95C, TYR66K, TYR87C, TYR89C, VAL72K, VAL80C, VAL94C
• D-E: ALA100D, ALA102D, ALA104D, ALA20E, ALA49E, ALA77E, ALA9D, ARG140D, ARG14D, ARG14E, ARG16D, ARG16E, ARG222E, ARG26E, ARG75E, ARG76E, ARG85D, ARG97D, ASN101D, ASN45E, ASN69E, ASN73E, ASP144D, ASP149D, ASP15E, GLN105D, GLN114D, GLN114E, GLN11D, GLN137D, GLN151D, GLU10D, GLU113D, GLU119E, GLU150D, GLU18E, GLU70E, GLU72E, GLY108D, GLY145D, GLY23E, HIS51E, HIS81D, ILE110D, ILE110E, ILE12D, ILE12E, ILE141D, ILE147D, LEU107D, LEU138D, LEU19E, LEU50E, LEU74E, LYS116E, LYS134D, LYS22E, LYS67E, MET13D, PHE111D, PRO115E, PRO117E, PRO46E, SER146D, SER17E, SER47E, SER98D, THR106D, THR109D, THR112D, THR142D, THR48E, TYR103D, TYR118E, TYR139D, TYR143D, TYR68E, VAL148D
• D-K: ALA-32K, ALA100D, ALA102D, ALA104D, ALA202K, ALA49D, ALA60K, ALA77D, ALA82D, ARG215D, ARG217D, ARG218D, ARG222D, ARG57K, ARG75D, ARG76D, ARG85D, ARG91D, ARG92D, ASN-44K, ASN101D, ASN69D, ASN73D, ASP38K, ASP58D, ASP83D, ASP90D, GLN105D, GLN114D, GLU-30K, GLU39K, GLU54K, GLU55D, GLU62K, GLU64K, GLU67K, GLU70D, GLU70K, GLU72D, GLY-46K, GLY71K, GLY78D, GLY86D, HIS-33K, HIS204K, HIS51D, HIS65K, HIS81D, ILE110D, ILE122D, ILE53K, ILE69K, ILE79D, LEU-28K, LEU-29K, LEU-36K, LEU-43K, LEU-49K, LEU107D, LEU55K, LEU56D, LEU58K, LEU60D, LEU63K, LEU74D, LEU99D, LYS68K, MET84D, PHE-40K, PHE-47K, PHE220D, PHE59K, PHE71D, PRO-27K, PRO73K, SER-41K, SER-42K, SER-45K, SER-48K, SER54D, SER88D, SER98D, THR106D, THR109D, THR37K, TYR-37K, TYR103D, TYR118D, TYR57D, TYR66K, TYR87D, TYR89D, VAL203K, VAL36K, VAL56K, VAL61K, VAL72K, VAL80D, VAL94D
• D-L: ALA102D, ALA111L, ALA80L, ALA84L, ARG119L, ARG129D, ARG129L, ARG82L, ARG85D, ARG88L, ARG91D, ARG92D, ARG97D, ASN-44L, ASN101D, ASN81L, ASP-38L, ASP108L, ASP110L, ASP112L, ASP77L, ASP83D, ASP90D, ASP93D, GLN105D, GLU62L, GLU67L, GLU70L, GLY-46L, GLY131D, GLY71L, GLY78L, GLY86D, HIS65L, HIS81D, ILE69L, LEU-43L, LEU109L, LEU63L, LEU74L, LEU83L, LEU99D, LYS79L, MET84D, MET86L, PHE-40L, PHE-47L, PHE76L, PRO73L, SER-41L, SER-42L, SER-45L, SER85L, SER88D, SER98D, THR-39L, THR106D, THR75L, THR95D, TYR66L, TYR87D, TYR89D, VAL72L, VAL80D, VAL94D
• E-F: ALA100E, ALA102E, ALA104E, ALA20F, ALA49F, ALA77F, ALA9E, ARG140E, ARG14E, ARG14F, ARG16E, ARG16F, ARG222F, ARG26F, ARG75F, ARG76F, ARG85E, ARG97E, ASN101E, ASN45F, ASN69F, ASN73F, ASP144E, ASP149E, ASP15F, GLN105E, GLN114E, GLN114F, GLN11E, GLN137E, GLN151E, GLU10E, GLU113E, GLU119F, GLU150E, GLU18F, GLU70F, GLU72F, GLY108E, GLY145E, GLY23F, HIS51F, HIS81E, ILE110E, ILE110F, ILE12E, ILE12F, ILE141E, ILE147E, LEU107E, LEU138E, LEU19F, LEU50F, LEU74F, LYS116F, LYS134E, LYS22F, LYS67F, MET13E, MET13F, PHE111E, PRO115F, PRO117F, PRO46F, SER146E, SER17F, SER47F, SER98E, THR106E, THR109E, THR112E, THR142E, THR48F, TYR103E, TYR118F, TYR139E, TYR143E, TYR68F, VAL148E
• E-L: ALA-32L, ALA100E, ALA102E, ALA104E, ALA202L, ALA49E, ALA60L, ALA77E, ALA82E, ARG217E, ARG218E, ARG222E, ARG57L, ARG75E, ARG76E, ARG85E, ARG91E, ARG92E, ASN-44L, ASN101E, ASN69E, ASN73E, ASP38L, ASP58E, ASP83E, ASP90E, GLN105E, GLN114E, GLU-30L, GLU39L, GLU54L, GLU55E, GLU62L, GLU64L, GLU67L, GLU70E, GLU70L, GLU72E, GLY-46L, GLY71L, GLY78E, GLY86E, HIS-33L, HIS204L, HIS51E, HIS65L, HIS81E, ILE110E, ILE122E, ILE53L, ILE69L, ILE79E, LEU-28L, LEU-29L, LEU-36L, LEU-43L, LEU-49L, LEU107E, LEU55L, LEU56E, LEU58L, LEU60E, LEU63L, LEU74E, LEU99E, LYS68L, MET84E, PHE-40L, PHE-47L, PHE220E, PHE59L, PHE71E, PRO-27L, PRO73L, SER-41L, SER-42L, SER-45L, SER-48L, SER54E, SER88E, SER98E, THR106E, THR109E, THR37L, TYR-37L, TYR103E, TYR118E, TYR57E, TYR66L, TYR87E, TYR89E, VAL203L, VAL36L, VAL56L, VAL61L, VAL72L, VAL80E, VAL94E
• E-M: ALA102E, ALA111M, ALA80M, ALA84M, ARG119M, ARG129E, ARG129M, ARG82M, ARG85E, ARG88M, ARG91E, ARG92E, ARG97E, ASN-44M, ASN101E, ASN81M, ASP-38M, ASP108M, ASP110M, ASP112M, ASP77M, ASP83E, ASP90E, ASP93E, GLN105E, GLU62M, GLU67M, GLU70M, GLY-46M, GLY131E, GLY71M, GLY78M, GLY86E, HIS65M, HIS81E, ILE69M, LEU-43M, LEU109M, LEU63M, LEU74M, LEU83M, LEU99E, LYS79M, MET84E, MET86M, PHE-40M, PHE-47M, PHE76M, PRO73M, SER-41M, SER-42M, SER-45M, SER85M, SER88E, SER98E, THR-39M, THR106E, THR75M, THR95E, TYR66M, TYR87E, TYR89E, VAL72M, VAL80E, VAL94E
• F-G: ALA100F, ALA102F, ALA104F, ALA20G, ALA49G, ALA77G, ALA9F, ARG140F, ARG14F, ARG14G, ARG16F, ARG16G, ARG222G, ARG26G, ARG75G, ARG76G, ARG85F, ARG97F, ASN101F, ASN45G, ASN69G, ASN73G, ASP144F, ASP149F, ASP15G, GLN105F, GLN114F, GLN114G, GLN11F, GLN137F, GLN151F, GLU10F, GLU113F, GLU119G, GLU150F, GLU18G, GLU70G, GLU72G, GLY108F, GLY145F, GLY23G, HIS51G, HIS81F, ILE110F, ILE110G, ILE12F, ILE12G, ILE141F, ILE147F, LEU107F, LEU138F, LEU19G, LEU50G, LEU74G, LYS116G, LYS134F, LYS22G, LYS67G, MET13F, PHE111F, PRO115G, PRO117G, PRO46G, SER146F, SER17G, SER47G, SER98F, THR106F, THR109F, THR112F, THR142F, THR48G, TYR103F, TYR118G, TYR139F, TYR143F, TYR68G, VAL148F
• F-M: ALA-32M, ALA100F, ALA102F, ALA104F, ALA202M, ALA49F, ALA60M, ALA77F, ALA82F, ARG215F, ARG217F, ARG218F, ARG222F, ARG57M, ARG75F, ARG76F, ARG85F, ARG91F, ARG92F, ASN-44M, ASN101F, ASN69F, ASN73F, ASP38M, ASP58F, ASP83F, ASP90F, GLN105F, GLN114F, GLU-30M, GLU39M, GLU54M, GLU55F, GLU62M, GLU64M, GLU67M, GLU70F, GLU70M, GLU72F, GLY-46M, GLY71M, GLY78F, GLY86F, HIS-33M, HIS204M, HIS51F, HIS65M, HIS81F, ILE110F, ILE122F, ILE53M, ILE69M, ILE79F, LEU-28M, LEU-29M, LEU-36M, LEU-43M, LEU-49M, LEU107F, LEU55M, LEU56F, LEU58M, LEU60F, LEU63M, LEU74F, LEU99F, LYS68M, MET84F, PHE-40M, PHE-47M, PHE220F, PHE59M, PHE71F, PRO-27M, PRO73M, SER-41M, SER-42M, SER-45M, SER-48M, SER54F, SER88F, SER98F, THR106F, THR109F, THR37M, TYR-37M, TYR103F, TYR118F, TYR57F, TYR66M, TYR87F, TYR89F, VAL203M, VAL36M, VAL56M, VAL61M, VAL72M, VAL80F, VAL94F
• F-N: ALA102F, ALA111N, ALA80N, ALA84N, ARG119N, ARG129F, ARG129N, ARG82N, ARG85F, ARG88N, ARG91F, ARG92F, ARG97F, ASN-44N, ASN101F, ASN81N, ASP-38N, ASP108N, ASP110N, ASP112N, ASP77N, ASP83F, ASP90F, ASP93F, GLN105F, GLU62N, GLU67N, GLU70N, GLY-46N, GLY131F, GLY71N, GLY78N, GLY86F, HIS65N, HIS81F, ILE69N, LEU-43N, LEU109N, LEU63N, LEU74N, LEU83N, LEU99F, LYS79N, MET84F, MET86N, PHE-40N, PHE-47N, PHE76N, PRO73N, SER-41N, SER-42N, SER-45N, SER85N, SER88F, SER98F, THR-39N, THR106F, THR75N, THR95F, TYR66N, TYR87F, TYR89F, VAL72N, VAL80F, VAL94F
• G-H: ALA102G, ALA111H, ALA80H, ALA84H, ARG119H, ARG129G, ARG129H, ARG82H, ARG85G, ARG88H, ARG91G, ARG92G, ARG97G, ASN-44H, ASN101G, ASN81H, ASP-38H, ASP108H, ASP110H, ASP112H, ASP77H, ASP83G, ASP90G, ASP93G, GLN105G, GLU62H, GLU67H, GLU70H, GLY-46H, GLY131G, GLY71H, GLY78H, GLY86G, HIS65H, HIS81G, ILE69H, LEU-43H, LEU109H, LEU63H, LEU74H, LEU83H, LEU99G, LYS79H, MET84G, MET86H, PHE-40H, PHE-47H, PHE76H, PRO73H, SER-41H, SER-42H, SER-45H, SER85H, SER88G, SER98G, THR-39H, THR106G, THR75H, THR95G, TYR66H, TYR87G, TYR89G, VAL72H, VAL80G, VAL94G
• G-N: ALA-32N, ALA100G, ALA102G, ALA104G, ALA202N, ALA49G, ALA60N, ALA77G, ALA82G, ARG215G, ARG217G, ARG218G, ARG222G, ARG57N, ARG75G, ARG76G, ARG85G, ARG91G, ARG92G, ASN-44N, ASN101G, ASN69G, ASN73G, ASP38N, ASP58G, ASP83G, ASP90G, GLN105G, GLN114G, GLU-30N, GLU39N, GLU54N, GLU55G, GLU62N, GLU64N, GLU67N, GLU70G, GLU70N, GLU72G, GLY-46N, GLY71N, GLY78G, GLY86G, HIS-33N, HIS204N, HIS51G, HIS65N, HIS81G, ILE110G, ILE122G, ILE53N, ILE69N, ILE79G, LEU-28N, LEU-29N, LEU-36N, LEU-43N, LEU-49N, LEU107G, LEU55N, LEU56G, LEU58N, LEU60G, LEU63N, LEU74G, LEU99G, LYS68N, MET84G, PHE-40N, PHE-47N, PHE220G, PHE59N, PHE71G, PRO-27N, PRO73N, SER-41N, SER-42N, SER-45N, SER-48N, SER54G, SER88G, SER98G, THR106G, THR109G, THR37N, TYR-37N, TYR103G, TYR118G, TYR57G, TYR66N, TYR87G, TYR89G, VAL203N, VAL36N, VAL56N, VAL61N, VAL72N, VAL80G, VAL94G
• H-I: ALA-32H, ALA-4H, ALA134I, ALA20H, ALA27H, ALA49H, ALA52H, ALA84I, ALA93H, ALA94I, ALA99I, ARG-24H, ARG-35I, ARG129I, ARG133I, ARG188H, ARG18H, ARG29H, ARG57H, ARG82I, ARG88I, ASN-25H, ASN-44I, ASN81I, ASN90I, ASP-38I, ASP-6H, ASP124I, ASP30H, ASP77I, GLN22H, GLN96H, GLU-26H, GLU-26I, GLU-30H, GLU131I, GLU132I, GLU32H, GLU54H, GLY-1H, GLY127I, GLY128I, GLY50H, GLY78I, GLY89I, GLY92I, GLY97H, GLY97I, HIS-2H, HIS-33H, HIS137I, ILE26H, ILE51H, ILE53H, LEU-28H, LEU-28I, LEU-29H, LEU-36H, LEU-43I, LEU-49H, LEU-5H, LEU144I, LEU25H, LEU58H, LEU91I, LEU98H, LYS147I, LYS151I, MET95I, PHE-40H, PRO-27H, PRO-31H, PRO-3H, SER-48H, SER122I, SER28H, SER85I, THR-39I, THR48H, TYR-37H, TYR123I, TYR130I, VAL101I, VAL125I, VAL126I, VAL31H
• H-N: ALA-32N, ALA-4N, ALA134H, ALA20N, ALA27N, ALA49N, ALA52N, ALA84H, ALA93N, ALA94H, ALA99H, ARG-24N, ARG-35H, ARG129H, ARG133H, ARG188N, ARG18N, ARG29N, ARG57N, ARG82H, ARG88H, ASN-25N, ASN-44H, ASN81H, ASN90H, ASP-38H, ASP-6N, ASP124H, ASP30N, ASP77H, GLN22N, GLN96N, GLU-26H, GLU-26N, GLU-30N, GLU131H, GLU132H, GLU32N, GLU54N, GLY-1N, GLY127H, GLY128H, GLY50N, GLY78H, GLY89H, GLY92H, GLY97H, GLY97N, HIS-2N, HIS-33N, HIS137H, ILE26N, ILE51N, ILE53N, LEU-28H, LEU-28N, LEU-29N, LEU-36N, LEU-43H, LEU-49N, LEU-5N, LEU144H, LEU25N, LEU58N, LEU91H, LEU98N, LYS147H, LYS151H, MET95H, PHE-40N, PRO-27N, PRO-31N, PRO-3N, SER-48N, SER122H, SER28N, SER85H, THR-39H, THR48N, TYR-37N, TYR123H, TYR130H, VAL101H, VAL125H, VAL126H, VAL31N
• I-J: ALA-32I, ALA-4I, ALA134J, ALA20I, ALA27I, ALA49I, ALA52I, ALA84J, ALA93I, ALA94J, ALA99J, ARG-24I, ARG-35J, ARG129J, ARG133J, ARG188I, ARG18I, ARG29I, ARG57I, ARG82J, ARG88J, ASN-25I, ASN-44J, ASN81J, ASN90J, ASP-38J, ASP-6I, ASP124J, ASP30I, ASP77J, GLN22I, GLN96I, GLU-26I, GLU-26J, GLU-30I, GLU131J, GLU132J, GLU32I, GLU54I, GLY-1I, GLY127J, GLY128J, GLY50I, GLY78J, GLY89J, GLY92J, GLY97I, GLY97J, HIS-2I, HIS-33I, HIS137J, ILE26I, ILE51I, ILE53I, LEU-28I, LEU-28J, LEU-29I, LEU-36I, LEU-43J, LEU-49I, LEU-5I, LEU144J, LEU25I, LEU58I, LEU91J, LEU98I, LYS147J, LYS151J, MET95J, PHE-40I, PRO-27I, PRO-31I, PRO-3I, SER-48I, SER122J, SER28I, SER85J, THR-39J, THR48I, TYR-37I, TYR123J, TYR130J, VAL101J, VAL125J, VAL126J, VAL31I
• J-K: ALA-32J, ALA-4J, ALA134K, ALA20J, ALA27J, ALA49J, ALA52J, ALA84K, ALA93J, ALA94K, ALA99K, ARG-24J, ARG-35K, ARG129K, ARG133K, ARG188J, ARG18J, ARG29J, ARG57J, ARG82K, ARG88K, ASN-25J, ASN-44K, ASN81K, ASN90K, ASP-38K, ASP-6J, ASP124K, ASP30J, ASP77K, GLN22J, GLN96J, GLN96K, GLU-26J, GLU-26K, GLU-30J, GLU131K, GLU132K, GLU32J, GLU54J, GLY-1J, GLY127K, GLY128K, GLY50J, GLY78K, GLY89K, GLY92K, GLY97J, GLY97K, HIS-2J, HIS-33J, HIS137K, ILE26J, ILE51J, ILE53J, LEU-28J, LEU-28K, LEU-29J, LEU-36J, LEU-43K, LEU-49J, LEU-5J, LEU144K, LEU25J, LEU58J, LEU91K, LEU98J, LYS147K, LYS151K, MET95K, PHE-40J, PRO-27J, PRO-31J, PRO-3J, SER-48J, SER122K, SER28J, SER85K, THR-39K, THR48J, TYR-37J, TYR123K, TYR130K, VAL100J, VAL101K, VAL125K, VAL126K, VAL31J
• K-L: ALA-32K, ALA-4K, ALA134L, ALA20K, ALA27K, ALA49K, ALA52K, ALA84L, ALA93K, ALA94L, ALA99L, ARG-24K, ARG-35L, ARG129L, ARG133L, ARG188K, ARG18K, ARG29K, ARG57K, ARG82L, ARG88L, ASN-25K, ASN-44L, ASN81L, ASN90L, ASP-38L, ASP-6K, ASP124L, ASP30K, ASP77L, GLN22K, GLN96K, GLU-26K, GLU-26L, GLU-30K, GLU131L, GLU132L, GLU32K, GLU54K, GLY127L, GLY128L, GLY50K, GLY78L, GLY89L, GLY92L, GLY97K, GLY97L, HIS-2K, HIS-33K, HIS137L, ILE26K, ILE51K, ILE53K, LEU-28K, LEU-28L, LEU-29K, LEU-36K, LEU-43L, LEU-49K, LEU-5K, LEU144L, LEU25K, LEU58K, LEU91L, LEU98K, LYS147L, LYS151L, MET95L, PHE-40K, PRO-27K, PRO-31K, PRO-3K, SER-48K, SER122L, SER28K, SER85L, THR-39L, THR48K, TYR-37K, TYR123L, TYR130L, VAL101L, VAL125L, VAL126L, VAL31K
• L-M: ALA-32L, ALA-4L, ALA134M, ALA20L, ALA27L, ALA49L, ALA52L, ALA84M, ALA93L, ALA94M, ALA99M, ARG-24L, ARG-35M, ARG129M, ARG133M, ARG188L, ARG18L, ARG29L, ARG57L, ARG82M, ARG88M, ASN-25L, ASN-44M, ASN81M, ASN90M, ASP-38M, ASP-6L, ASP124M, ASP30L, ASP77M, GLN22L, GLN96L, GLU-26L, GLU-26M, GLU-30L, GLU131M, GLU132M, GLU32L, GLU54L, GLY127M, GLY128M, GLY50L, GLY78M, GLY89M, GLY92M, GLY97L, GLY97M, HIS-2L, HIS-33L, HIS137M, ILE26L, ILE51L, ILE53L, LEU-28L, LEU-28M, LEU-29L, LEU-36L, LEU-43M, LEU-49L, LEU-5L, LEU144M, LEU25L, LEU58L, LEU91M, LEU98L, LYS147M, LYS151M, MET95M, PHE-40L, PRO-27L, PRO-31L, PRO-3L, SER-48L, SER122M, SER28L, SER85M, THR-39M, THR48L, TYR-37L, TYR123M, TYR130M, VAL101M, VAL125M, VAL126M, VAL31L
• M-N: ALA-32M, ALA-4M, ALA134N, ALA20M, ALA27M, ALA49M, ALA52M, ALA84N, ALA93M, ALA94N, ALA99N, ARG-24M, ARG-35N, ARG129N, ARG133N, ARG188M, ARG18M, ARG29M, ARG57M, ARG82N, ARG88N, ASN-25M, ASN-44N, ASN81N, ASN90N, ASP-38N, ASP-6M, ASP124N, ASP30M, ASP77N, GLN22M, GLN96M, GLU-26M, GLU-26N, GLU-30M, GLU131N, GLU132N, GLU32M, GLU54M, GLY-1M, GLY127N, GLY128N, GLY50M, GLY78N, GLY89N, GLY92N, GLY97M, GLY97N, HIS-2M, HIS-33M, HIS137N, ILE26M, ILE51M, ILE53M, LEU-28M, LEU-28N, LEU-29M, LEU-36M, LEU-43N, LEU-49M, LEU-5M, LEU144N, LEU25M, LEU58M, LEU91N, LEU98M, LYS147N, LYS151N, MET95N, PHE-40M, PRO-27M, PRO-31M, PRO-3M, SER-48M, SER122N, SER28M, SER85N, THR-39N, THR48M, TYR-37M, TYR123N, TYR130N, VAL101N, VAL125N, VAL126N, VAL31M