1Q52

crystal structure of mycobacterium tuberculosis menb, a key enzyme in vitamin k2 biosynthesis

• Total interactions analyzed: 66
• Total true interactions: 36
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 122
  • Norm. En. per Res.: -4.8759
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-98.5623	-75.5186	-420.779	-594.8599	122	18	16	15435	5	25	22
A-C	-89.0699	-54.5442	-419.426	-563.0401	121	19	16	15613	5	26	24
A-D	-33.5174	3.2264	-405.82	-436.111	163	5	12	15880	7	37	36
A-E	-39.1057	-3.1753	-474.003	-516.2841	154	14	12	17848	0	24	29
A-F	0.0	0.0	-0.0366	-0.0366	6	0	0	27	0	0	0
B-C	-105.4923	-56.9818	-477.966	-640.44	138	19	18	17781	6	25	24
B-D	-30.8264	0.5695	-464.119	-494.3758	156	13	11	17891	0	25	29
B-E	0.0	0.0	-0.0396	-0.0396	6	0	0	29	0	0	0
B-F	-40.0249	4.2834	-441.059	-476.8005	180	14	10	18006	6	42	46
C-D	0.0	0.0	-0.042	-0.042	6	0	0	31	0	0	0
C-E	-34.374	3.1543	-398.86	-430.0797	162	9	11	15756	6	37	35
C-F	-29.6236	-0.9347	-476.351	-506.9093	154	20	11	18002	0	24	29
D-E	-97.3908	-56.1035	-416.672	-570.1663	122	17	16	15465	4	25	23
D-F	-82.4059	-52.3157	-404.848	-539.5695	121	20	16	15441	4	24	22
D-G	-29.6635	-46.7179	-90.0849	-166.4663	67	5	0	4454	6	30	26
D-H	0.0	18.2543	-7.7262	10.5281	18	0	0	436	0	6	11
E-F	-95.9461	-58.229	-408.352	-562.5271	122	18	16	15526	5	26	22
E-G	0.0	18.371	-7.2026	11.1684	20	0	0	428	0	7	11
E-I	-26.8889	-46.4588	-78.8206	-152.1684	61	2	0	4134	3	30	26
F-H	-45.3778	-48.2358	-92.6535	-186.2671	63	6	0	4538	6	30	26
F-I	0.0	0.0	-5.7946	-5.7946	18	0	0	350	0	6	11
G-H	-94.0961	-56.22	-409.911	-560.2271	121	19	16	15449	5	26	24
G-I	-85.9046	-59.432	-414.333	-559.6697	122	16	16	15511	5	25	23
G-J	-32.2832	3.149	-404.301	-433.4351	158	7	10	15706	7	37	36
G-K	-32.2503	-3.423	-465.956	-501.6293	155	26	12	17796	0	25	31
G-L	0.0	0.0	-0.0457	-0.0457	6	0	0	33	0	0	0
H-I	-86.0125	-53.5245	-407.381	-546.918	122	18	16	15393	5	26	23
H-J	-44.6451	1.5777	-469.408	-512.4754	158	14	12	17884	0	24	29
H-K	0.0	0.0	-0.0378	-0.0378	6	0	0	29	0	0	0
H-L	-35.0692	3.195	-404.035	-435.9092	162	5	12	15783	7	37	36
I-J	0.0	0.0	-0.044	-0.044	6	0	0	32	0	0	0
I-K	-31.8844	4.2947	-392.526	-420.1156	163	5	10	15651	6	36	36
I-L	-37.6222	-2.0177	-474.732	-514.3719	158	17	10	17964	0	25	31
J-K	-87.9673	-54.6918	-413.389	-556.0481	122	15	16	15499	5	25	23
J-L	-82.5334	-50.0045	-413.207	-545.7449	120	15	16	15465	5	25	22
K-L	-98.4026	-54.7819	-418.429	-571.6136	120	14	16	15538	5	25	23

Interface residues

• A-B: ALA186A, ALA198A, ALA201A, ALA201B, ALA209A, ALA229B, ALA232B, ALA247B, ALA248B, ALA252B, ALA257B, ALA264B, ALA282B, ARG141A, ARG144B, ARG202A, ARG202B, ARG210A, ARG217A, ARG259B, ASN231B, ASN251B, ASN266B, ASP170B, ASP185A, ASP187A, ASP192A, ASP269A, ASP269B, ASP270A, ASP270B, CYS152B, CYS169B, GLN183A, GLN203A, GLN203B, GLN206A, GLN223A, GLN226A, GLN226B, GLN245B, GLN256B, GLN258B, GLU138A, GLU211A, GLU249B, GLU281B, GLY189A, GLY193A, GLY194A, GLY196A, GLY205A, GLY205B, GLY216A, GLY228B, GLY243B, GLY271A, GLY271B, HIS135A, HIS163B, HIS166B, HIS225B, ILE143B, ILE151B, ILE212A, ILE250B, LEU137A, LEU165B, LEU171B, LEU173B, LEU200A, LEU200B, LEU215A, LEU244B, LEU261B, LEU267B, LEU268A, LEU268B, LEU285B, LYS148B, LYS182A, LYS207A, LYS253B, LYS262B, MET224B, MET227A, MET227B, MET260B, PHE181B, PHE191A, PHE208A, PHE213A, PHE214A, PHE263B, PHE265B, PHE278B, PHE314B, PRO255B, SER164B, SER190A, SER197A, SER254B, THR172B, THR184A, THR218A, TRP246B, TYR195A, TYR195B, TYR199A, TYR199B, TYR219A, VAL149B, VAL150B, VAL154B, VAL167B, VAL168B, VAL188A, VAL204A, VAL204B, VAL230B, VAL242B, VAL84B
• A-C: ALA186C, ALA198C, ALA201A, ALA201C, ALA209C, ALA229A, ALA232A, ALA247A, ALA248A, ALA252A, ALA257A, ALA264A, ALA282A, ARG141C, ARG144A, ARG202A, ARG202C, ARG210C, ARG217C, ARG259A, ASN231A, ASN251A, ASN266A, ASP170A, ASP185C, ASP187C, ASP192C, ASP269A, ASP269C, ASP270A, ASP270C, CYS152A, CYS169A, GLN183C, GLN203A, GLN203C, GLN206C, GLN223C, GLN226A, GLN226C, GLN245A, GLN256A, GLN258A, GLU138C, GLU211C, GLU249A, GLU281A, GLY189C, GLY193C, GLY194C, GLY196C, GLY205A, GLY205C, GLY216C, GLY228A, GLY243A, GLY271C, HIS135C, HIS163A, HIS166A, HIS225A, ILE143A, ILE151A, ILE212C, ILE250A, LEU137C, LEU165A, LEU171A, LEU173A, LEU200A, LEU200C, LEU215C, LEU261A, LEU267A, LEU268A, LEU268C, LEU285A, LYS148A, LYS182C, LYS207C, LYS253A, LYS262A, MET224A, MET227A, MET227C, MET260A, PHE181A, PHE191C, PHE208C, PHE213C, PHE214C, PHE263A, PHE265A, PHE278A, PHE314A, PRO255A, SER164A, SER190C, SER197C, SER254A, THR172A, THR184C, THR218C, TRP246A, TYR195A, TYR195C, TYR199A, TYR199C, TYR219C, VAL149A, VAL150A, VAL154A, VAL167A, VAL168A, VAL188C, VAL204A, VAL204C, VAL230A, VAL233A, VAL242A, VAL84A
• A-D: ALA186A, ALA186D, ALA198A, ALA198D, ALA201A, ALA201D, ALA279A, ALA279D, ALA282A, ALA282D, ALA286A, ALA286D, ALA292A, ALA292D, ALA298A, ALA298D, ALA60A, ARG141A, ARG141D, ARG144A, ARG144D, ARG202A, ARG202D, ARG284A, ARG284D, ARG296A, ARG296D, ARG58A, ARG77A, ARG77D, ASN266A, ASN266D, ASP106A, ASP106D, ASP185A, ASP185D, ASP187A, ASP187D, ASP192A, ASP192D, ASP269A, ASP269D, ASP270A, ASP270D, ASP297A, ASP297D, ASP74A, ASP74D, GLN140A, GLN140D, GLN203A, GLN203D, GLN206A, GLN206D, GLN275A, GLN275D, GLN276A, GLN276D, GLU138A, GLU138D, GLU281A, GLU281D, GLU291A, GLU291D, GLU294A, GLU294D, GLY105A, GLY105D, GLY189A, GLY189D, GLY193A, GLY193D, GLY194A, GLY194D, GLY196A, GLY196D, GLY271A, GLY271D, GLY274A, GLY274D, GLY280A, GLY280D, GLY295A, GLY295D, HIS135A, HIS135D, ILE136A, ILE136D, ILE143A, ILE143D, LEU137A, LEU137D, LEU142A, LEU142D, LEU200A, LEU200D, LEU267A, LEU267D, LEU268A, LEU268D, LEU272A, LEU272D, LEU277A, LEU277D, LEU285A, LEU285D, LEU300A, LEU300D, LYS302D, MET146A, MET146D, MET78A, MET78D, PHE145A, PHE145D, PHE191A, PHE191D, PHE263A, PHE263D, PHE265A, PHE265D, PHE278A, PHE278D, PHE299A, PHE299D, PRO147A, PRO147D, PRO305A, PRO305D, SER103A, SER103D, SER190A, SER190D, SER197A, SER197D, THR184A, THR184D, THR283A, THR283D, THR289A, THR289D, TRP307A, TRP307D, TYR195A, TYR195D, TYR199A, TYR199D, TYR287A, TYR287D, TYR70A, TYR70D, VAL139A, VAL139D, VAL167A, VAL167D, VAL168A, VAL168D, VAL188A, VAL188D, VAL273A, VAL273D, VAL293A, VAL293D
• A-E: ALA247E, ALA248E, ALA252A, ALA252E, ALA257A, ALA257E, ALA264A, ALA264E, ALA279A, ALA279E, ALA282A, ALA282E, ALA286A, ALA286E, ALA292A, ALA292E, ALA46A, ALA46E, ALA76A, ALA76E, ARG259A, ARG259E, ARG284A, ARG284E, ARG296E, ARG312A, ARG312E, ARG41A, ARG41E, ARG77A, ARG77E, ASN251A, ASN251E, ASN266A, ASN266E, ASP269A, ASP269E, ASP270A, ASP270E, ASP290A, ASP290E, ASP306A, ASP306E, ASP45A, ASP45E, ASP74A, ASP74E, ASP81A, ASP81E, GLN256A, GLN256E, GLN258A, GLN258E, GLN275A, GLN275E, GLN276A, GLN276E, GLU281A, GLU281E, GLU291A, GLU291E, GLU294A, GLU294E, GLY271A, GLY271E, GLY274A, GLY274E, GLY280A, GLY280E, GLY295A, GLY295E, GLY83A, GLY83E, ILE250A, ILE250E, LEU261A, LEU261E, LEU267A, LEU267E, LEU268A, LEU268E, LEU272A, LEU272E, LEU277A, LEU277E, LEU285A, LEU285E, LYS148A, LYS148E, LYS253A, LYS253E, LYS262A, LYS262E, MET146A, MET146E, MET260A, MET260E, MET288A, MET288E, MET78A, MET78E, PHE145A, PHE145E, PHE263A, PHE263E, PHE265A, PHE265E, PHE278A, PHE278E, PHE310A, PHE310E, PHE314A, PHE314E, PRO147A, PRO147E, PRO255A, PRO255E, PRO304A, PRO304E, PRO305A, PRO305E, PRO309E, PRO311A, PRO311E, PRO80A, PRO80E, SER254A, SER254E, SER308A, SER308E, SER79A, SER79E, THR283A, THR283E, THR289A, THR289E, THR47A, THR47E, TRP307A, TRP307E, TYR287A, TYR287E, TYR313A, TYR313E, VAL149A, VAL149E, VAL273A, VAL273E, VAL293A, VAL293E, VAL82A, VAL82E, VAL84A, VAL84E
• A-F: ARG210A, ARG210F, GLN206A, GLN206F, LEU272A, LEU272F
• B-C: ALA129B, ALA131B, ALA186B, ALA198B, ALA201B, ALA201C, ALA209B, ALA229C, ALA232C, ALA247C, ALA248C, ALA252C, ALA257C, ALA264C, ALA282C, ARG130B, ARG133B, ARG141B, ARG144C, ARG202B, ARG202C, ARG210B, ARG217B, ARG259C, ARG312C, ASN231C, ASN251C, ASN266C, ASP127B, ASP170C, ASP185B, ASP187B, ASP192B, ASP269B, ASP269C, ASP270B, ASP270C, CYS152C, CYS169C, GLN183B, GLN203B, GLN203C, GLN206B, GLN223B, GLN226B, GLN226C, GLN245C, GLN256C, GLN258C, GLU138B, GLU211B, GLU249C, GLU281C, GLY132B, GLY189B, GLY193B, GLY194B, GLY196B, GLY205B, GLY205C, GLY216B, GLY228C, GLY243C, GLY271B, GLY271C, HIS135B, HIS163C, HIS166C, HIS225C, ILE143C, ILE151C, ILE212B, ILE250C, LEU134B, LEU137B, LEU165C, LEU171C, LEU173C, LEU200B, LEU200C, LEU215B, LEU261C, LEU267C, LEU268B, LEU268C, LEU285C, LYS148C, LYS182B, LYS207B, LYS253C, LYS262C, MET224C, MET227B, MET227C, MET260C, PHE181C, PHE191B, PHE208B, PHE213B, PHE214B, PHE263C, PHE265C, PHE278C, PHE310C, PHE314C, PRO255C, PRO309C, PRO311C, SER164C, SER190B, SER197B, SER254C, SER308C, THR125B, THR172C, THR184B, THR218B, TRP246C, TRP307C, TYR195B, TYR195C, TYR199B, TYR199C, TYR219B, TYR313C, VAL126B, VAL128B, VAL149C, VAL150C, VAL154C, VAL167C, VAL168C, VAL188B, VAL204B, VAL204C, VAL230C, VAL242C, VAL84C
• B-D: ALA247B, ALA247D, ALA248D, ALA252B, ALA252D, ALA257B, ALA257D, ALA264B, ALA264D, ALA279B, ALA279D, ALA282B, ALA282D, ALA286B, ALA286D, ALA292B, ALA292D, ALA46B, ALA46D, ALA76B, ALA76D, ARG259B, ARG259D, ARG284B, ARG284D, ARG296D, ARG312B, ARG312D, ARG41B, ARG41D, ARG77B, ARG77D, ASN251B, ASN251D, ASN266B, ASN266D, ASP269B, ASP269D, ASP270B, ASP270D, ASP290B, ASP290D, ASP306B, ASP306D, ASP45B, ASP45D, ASP74B, ASP74D, ASP81B, ASP81D, GLN256B, GLN256D, GLN258B, GLN258D, GLN275B, GLN275D, GLN276B, GLN276D, GLU281B, GLU281D, GLU291B, GLU291D, GLU294B, GLU294D, GLY271B, GLY271D, GLY274B, GLY274D, GLY280B, GLY280D, GLY295B, GLY295D, GLY83B, GLY83D, ILE250B, ILE250D, LEU261B, LEU261D, LEU267B, LEU267D, LEU268B, LEU268D, LEU272B, LEU272D, LEU277B, LEU277D, LEU285B, LEU285D, LYS148B, LYS148D, LYS253B, LYS253D, LYS262B, LYS262D, MET146B, MET146D, MET260B, MET260D, MET288B, MET288D, MET78B, MET78D, PHE145B, PHE145D, PHE263B, PHE263D, PHE265B, PHE265D, PHE278B, PHE278D, PHE310B, PHE310D, PHE314B, PHE314D, PRO147B, PRO147D, PRO255B, PRO255D, PRO304B, PRO304D, PRO305B, PRO305D, PRO309B, PRO309D, PRO311B, PRO311D, PRO80B, PRO80D, SER254B, SER254D, SER308B, SER308D, SER79B, SER79D, THR283B, THR283D, THR289B, THR289D, THR47B, THR47D, TRP307B, TRP307D, TYR287B, TYR287D, TYR313B, TYR313D, VAL149B, VAL149D, VAL273B, VAL273D, VAL293B, VAL293D, VAL82B, VAL82D, VAL84B, VAL84D
• B-E: ARG210B, ARG210E, GLN206B, GLN206E, LEU272B, LEU272E
• B-F: ALA129B, ALA131B, ALA186B, ALA186F, ALA198B, ALA198F, ALA201B, ALA201F, ALA279B, ALA279F, ALA282B, ALA282F, ALA286B, ALA286F, ALA292B, ALA292F, ALA298B, ALA298F, ARG130B, ARG133B, ARG141B, ARG141F, ARG144B, ARG144F, ARG202B, ARG202F, ARG259F, ARG284B, ARG284F, ARG296B, ARG296F, ARG58F, ARG77B, ARG77F, ASN266B, ASN266F, ASP106B, ASP106F, ASP127B, ASP185B, ASP185F, ASP187B, ASP187F, ASP192B, ASP192F, ASP269B, ASP269F, ASP270B, ASP270F, ASP297B, ASP297F, ASP74B, ASP74F, ASP81F, GLN140B, GLN140F, GLN203B, GLN203F, GLN206B, GLN206F, GLN275B, GLN275F, GLN276B, GLN276F, GLU138B, GLU138F, GLU281B, GLU281F, GLU291B, GLU291F, GLU294B, GLU294F, GLY105B, GLY105F, GLY132B, GLY189B, GLY189F, GLY193B, GLY193F, GLY194B, GLY194F, GLY196B, GLY196F, GLY271B, GLY271F, GLY274B, GLY274F, GLY280B, GLY280F, GLY295B, GLY295F, HIS135B, HIS135F, HIS75F, ILE136B, ILE136F, ILE143B, ILE143F, LEU134B, LEU137B, LEU137F, LEU142B, LEU142F, LEU200B, LEU200F, LEU267B, LEU267F, LEU268B, LEU268F, LEU272B, LEU272F, LEU277B, LEU277F, LEU285B, LEU285F, LEU300B, LEU300F, LYS148F, MET146B, MET146F, MET288F, MET78B, MET78F, PHE145B, PHE145F, PHE191B, PHE191F, PHE263B, PHE263F, PHE265B, PHE265F, PHE278B, PHE278F, PHE299B, PHE299F, PRO147B, PRO147F, PRO304F, PRO305B, PRO305F, PRO80F, SER103F, SER164B, SER190B, SER190F, SER197B, SER197F, SER79F, THR125B, THR184B, THR184F, THR283B, THR283F, THR289B, THR289F, TRP307B, TRP307F, TYR195B, TYR195F, TYR199B, TYR199F, TYR287B, TYR287F, TYR70B, TYR70F, VAL126B, VAL128B, VAL139B, VAL139F, VAL167B, VAL167F, VAL168B, VAL168F, VAL188B, VAL188F, VAL273B, VAL273F, VAL293B, VAL293F, VAL82F
• C-D: ARG210C, ARG210D, GLN206C, GLN206D, LEU272C, LEU272D
• C-E: ALA186C, ALA186E, ALA198C, ALA198E, ALA201C, ALA201E, ALA279C, ALA279E, ALA282C, ALA282E, ALA286C, ALA286E, ALA292C, ALA292E, ALA298C, ALA298E, ARG141C, ARG141E, ARG144C, ARG144E, ARG202C, ARG202E, ARG284C, ARG284E, ARG296C, ARG296E, ARG58C, ARG77C, ARG77E, ASN266C, ASN266E, ASP106C, ASP106E, ASP185C, ASP185E, ASP187C, ASP187E, ASP192C, ASP192E, ASP269C, ASP269E, ASP270C, ASP270E, ASP297C, ASP297E, ASP74C, ASP74E, GLN140C, GLN140E, GLN203C, GLN203E, GLN206C, GLN206E, GLN275C, GLN275E, GLN276C, GLN276E, GLU138C, GLU138E, GLU281C, GLU281E, GLU291C, GLU291E, GLU294C, GLU294E, GLY105C, GLY105E, GLY189C, GLY189E, GLY193C, GLY193E, GLY194C, GLY194E, GLY196C, GLY196E, GLY271C, GLY271E, GLY274C, GLY274E, GLY280C, GLY280E, GLY295C, GLY295E, HIS135C, HIS135E, ILE136C, ILE136E, ILE143C, ILE143E, LEU137C, LEU137E, LEU142C, LEU142E, LEU200C, LEU200E, LEU267C, LEU267E, LEU268C, LEU268E, LEU272C, LEU272E, LEU277C, LEU277E, LEU285C, LEU285E, LEU300C, LEU300E, LYS182C, MET146C, MET146E, MET78C, MET78E, PHE145C, PHE145E, PHE191C, PHE191E, PHE263C, PHE263E, PHE265C, PHE265E, PHE278C, PHE278E, PHE299C, PHE299E, PRO147C, PRO147E, PRO305C, PRO305E, SER103C, SER103E, SER190C, SER190E, SER197C, SER197E, THR184C, THR184E, THR283C, THR283E, THR289C, THR289E, TRP307C, TRP307E, TYR195C, TYR195E, TYR199C, TYR199E, TYR287C, TYR287E, TYR70C, TYR70E, VAL139C, VAL139E, VAL167C, VAL167E, VAL168C, VAL168E, VAL188C, VAL188E, VAL273C, VAL273E, VAL293C, VAL293E
• C-F: ALA247F, ALA248F, ALA252C, ALA252F, ALA257C, ALA257F, ALA264C, ALA264F, ALA279C, ALA279F, ALA282C, ALA282F, ALA286C, ALA286F, ALA292C, ALA292F, ALA46C, ALA46F, ALA76C, ALA76F, ARG259C, ARG259F, ARG284C, ARG284F, ARG312C, ARG312F, ARG41C, ARG41F, ARG77C, ARG77F, ASN251C, ASN251F, ASN266C, ASN266F, ASP269C, ASP269F, ASP270C, ASP270F, ASP290C, ASP290F, ASP306C, ASP306F, ASP45C, ASP45F, ASP74C, ASP74F, ASP81C, ASP81F, GLN256C, GLN256F, GLN258C, GLN258F, GLN275C, GLN275F, GLN276C, GLN276F, GLU281C, GLU281F, GLU291C, GLU291F, GLU294C, GLU294F, GLY271C, GLY271F, GLY274C, GLY274F, GLY280C, GLY280F, GLY295C, GLY295F, GLY83C, GLY83F, ILE250C, ILE250F, LEU261C, LEU261F, LEU267C, LEU267F, LEU268C, LEU268F, LEU272C, LEU272F, LEU277C, LEU277F, LEU285C, LEU285F, LYS148C, LYS148F, LYS253C, LYS253F, LYS262C, LYS262F, MET146C, MET146F, MET260C, MET260F, MET288C, MET288F, MET78C, MET78F, PHE145C, PHE145F, PHE263C, PHE263F, PHE265C, PHE265F, PHE278C, PHE278F, PHE310C, PHE310F, PHE314C, PHE314F, PRO147C, PRO147F, PRO255C, PRO255F, PRO304C, PRO304F, PRO305C, PRO305F, PRO309C, PRO309F, PRO311C, PRO311F, PRO80C, PRO80F, SER254C, SER254F, SER308C, SER308F, SER79C, SER79F, THR283C, THR283F, THR289C, THR289F, THR47C, THR47F, TRP307C, TRP307F, TYR287C, TYR287F, TYR313C, TYR313F, VAL149C, VAL149F, VAL273C, VAL273F, VAL293C, VAL293F, VAL82C, VAL82F, VAL84C, VAL84F
• D-E: ALA186D, ALA198D, ALA201D, ALA201E, ALA209D, ALA229E, ALA232E, ALA247E, ALA248E, ALA252E, ALA257E, ALA264E, ALA282E, ARG141D, ARG144E, ARG202D, ARG202E, ARG210D, ARG217D, ARG259E, ASN231E, ASN251E, ASN266E, ASP170E, ASP185D, ASP187D, ASP192D, ASP269D, ASP269E, ASP270D, ASP270E, CYS152E, CYS169E, GLN183D, GLN203D, GLN203E, GLN206D, GLN223D, GLN226D, GLN226E, GLN245E, GLN256E, GLN258E, GLU138D, GLU211D, GLU249E, GLU281E, GLY189D, GLY193D, GLY194D, GLY196D, GLY205D, GLY205E, GLY216D, GLY228E, GLY243E, GLY271D, GLY271E, HIS135D, HIS163E, HIS166E, HIS225E, ILE143E, ILE151E, ILE212D, ILE250E, LEU137D, LEU165E, LEU171E, LEU173E, LEU200D, LEU200E, LEU215D, LEU261E, LEU267E, LEU268D, LEU268E, LEU285E, LYS148E, LYS182D, LYS207D, LYS253E, LYS262E, MET224E, MET227D, MET227E, MET260E, PHE181E, PHE191D, PHE208D, PHE213D, PHE214D, PHE263E, PHE265E, PHE278E, PHE314E, PRO255E, SER164E, SER190D, SER197D, SER254E, THR172E, THR184D, THR218D, TRP246E, TYR195D, TYR195E, TYR199D, TYR199E, TYR219D, VAL149E, VAL150E, VAL154E, VAL167D, VAL167E, VAL168E, VAL188D, VAL204D, VAL204E, VAL230E, VAL242E, VAL84E
• D-F: ALA186F, ALA198F, ALA201D, ALA201F, ALA209F, ALA229D, ALA232D, ALA247D, ALA248D, ALA252D, ALA257D, ALA264D, ALA282D, ARG141F, ARG144D, ARG202D, ARG202F, ARG210F, ARG217F, ARG259D, ASN231D, ASN251D, ASN266D, ASP170D, ASP185F, ASP187F, ASP192F, ASP269D, ASP269F, ASP270D, ASP270F, CYS152D, CYS169D, GLN183F, GLN203D, GLN203F, GLN206F, GLN223F, GLN226D, GLN226F, GLN245D, GLN256D, GLN258D, GLU138F, GLU211F, GLU249D, GLU281D, GLY189F, GLY193F, GLY194F, GLY196F, GLY205D, GLY205F, GLY216F, GLY228D, GLY243D, GLY271D, GLY271F, HIS135F, HIS163D, HIS166D, HIS225D, ILE143D, ILE151D, ILE212F, ILE250D, LEU137F, LEU165D, LEU171D, LEU173D, LEU200D, LEU200F, LEU215F, LEU261D, LEU267D, LEU268D, LEU268F, LEU285D, LYS148D, LYS182F, LYS207F, LYS253D, LYS262D, MET224D, MET227D, MET227F, MET260D, PHE181D, PHE191F, PHE208F, PHE213F, PHE214F, PHE263D, PHE265D, PHE278D, PHE314D, PRO255D, SER164D, SER190F, SER197F, SER254D, THR172D, THR184F, THR218F, TRP246D, TYR195D, TYR195F, TYR199D, TYR199F, TYR219F, VAL149D, VAL150D, VAL154D, VAL167D, VAL168D, VAL188F, VAL204D, VAL204F, VAL230D, VAL242D, VAL84D
• D-G: ALA179D, ALA179G, ALA221D, ALA221G, ALA234D, ALA234G, ALA237D, ALA237G, ARG176D, ARG176G, ARG180D, ARG180G, ARG217D, ARG217G, ARG58D, ARG58G, ASP96D, ASP96G, GLN223D, GLN223G, GLN226D, GLN226G, GLU177D, GLU177G, GLU211D, GLU211G, GLU222D, GLU222G, GLU235D, GLU235G, GLU238D, GLU238G, GLY216D, GLY216G, GLY97D, GLY97G, GLY98D, GLY98G, HIS236D, HIS236G, LEU215D, LEU215G, LYS182D, LYS182G, LYS95D, LYS95G, MET224D, MET224G, MET227D, MET227G, PHE181D, PHE181G, SER175D, SER175G, THR218D, THR218G, THR220D, THR220G, TRP157D, TRP157G, TRP99G, TYR178D, TYR178G, TYR219D, TYR219G, VAL233D, VAL233G
• D-H: ALA237D, ALA237H, GLN226D, GLN226H, GLN245D, GLN245H, GLU235D, GLU235H, GLU238D, GLU238H, GLU249D, GLU249H, THR241D, THR241H, TRP246D, TRP246H, VAL242D, VAL242H
• E-F: ALA186E, ALA198E, ALA201E, ALA201F, ALA209E, ALA229F, ALA232F, ALA247F, ALA248F, ALA252F, ALA257F, ALA264F, ALA282F, ARG141E, ARG144F, ARG202E, ARG202F, ARG210E, ARG217E, ARG259F, ASN231F, ASN251F, ASN266F, ASP170F, ASP185E, ASP187E, ASP192E, ASP269E, ASP269F, ASP270E, ASP270F, CYS152F, CYS169F, GLN183E, GLN203E, GLN203F, GLN206E, GLN223E, GLN226E, GLN226F, GLN245F, GLN256F, GLN258F, GLU138E, GLU211E, GLU249F, GLU281F, GLY189E, GLY193E, GLY194E, GLY196E, GLY205E, GLY205F, GLY216E, GLY228F, GLY243F, GLY271E, GLY271F, HIS135E, HIS163F, HIS166F, HIS225F, ILE143F, ILE151F, ILE212E, ILE250F, LEU137E, LEU165F, LEU171F, LEU173F, LEU200E, LEU200F, LEU215E, LEU261F, LEU267F, LEU268E, LEU268F, LEU285F, LYS148F, LYS182E, LYS207E, LYS253F, LYS262F, MET146F, MET224F, MET227E, MET227F, MET260F, PHE181F, PHE191E, PHE208E, PHE213E, PHE214E, PHE263F, PHE265F, PHE278F, PHE314F, PRO255F, SER164F, SER190E, SER197E, SER254F, THR172F, THR184E, THR218E, TRP246F, TYR195E, TYR195F, TYR199E, TYR199F, TYR219E, VAL149F, VAL150F, VAL154F, VAL167F, VAL168F, VAL188E, VAL204E, VAL204F, VAL230F, VAL242F, VAL84F
• E-G: ALA237E, ALA237G, ARG176E, ARG176G, GLN226E, GLN226G, GLN245E, GLN245G, GLU235E, GLU235G, GLU238E, GLU238G, GLU249E, GLU249G, THR241E, THR241G, TRP246E, TRP246G, VAL242E, VAL242G
• E-I: ALA179E, ALA179I, ALA221E, ALA221I, ALA234E, ALA237E, ALA237I, ARG176E, ARG176I, ARG180E, ARG180I, ARG217E, ARG217I, ARG58E, ARG58I, ASP96E, ASP96I, GLN223E, GLN223I, GLN226E, GLN226I, GLU177E, GLU177I, GLU222E, GLU222I, GLU235E, GLU235I, GLU238E, GLU238I, GLY97E, GLY97I, GLY98E, GLY98I, HIS236E, HIS236I, LEU215E, LEU215I, LYS182E, LYS182I, LYS95E, LYS95I, MET224E, MET224I, MET227E, MET227I, PHE181E, PHE181I, SER175E, SER175I, THR218E, THR218I, THR220E, THR220I, TRP157E, TRP157I, TYR178E, TYR178I, TYR219E, TYR219I, VAL233E, VAL233I
• F-H: ALA179F, ALA179H, ALA221F, ALA221H, ALA234H, ALA237F, ALA237H, ARG176F, ARG176H, ARG180F, ARG180H, ARG217F, ARG217H, ARG58F, ARG58H, ASP96F, ASP96H, GLN223F, GLN223H, GLN226F, GLN226H, GLU177F, GLU177H, GLU211H, GLU222F, GLU222H, GLU235F, GLU235H, GLU238F, GLU238H, GLY97F, GLY97H, GLY98F, GLY98H, HIS236F, HIS236H, LEU215F, LEU215H, LYS182F, LYS182H, LYS95F, LYS95H, MET224F, MET224H, MET227H, PHE181F, PHE181H, SER175F, SER175H, THR218F, THR218H, THR220F, THR220H, TRP157F, TRP157H, TRP99F, TRP99H, TYR178F, TYR178H, TYR219F, TYR219H, VAL233F, VAL233H
• F-I: ALA237F, ALA237I, GLN226F, GLN226I, GLN245F, GLN245I, GLU235F, GLU235I, GLU238F, GLU238I, GLU249F, GLU249I, THR241F, THR241I, TRP246F, TRP246I, VAL242F, VAL242I
• G-H: ALA186G, ALA198G, ALA201G, ALA201H, ALA209G, ALA229H, ALA232H, ALA247H, ALA248H, ALA252H, ALA257H, ALA264H, ALA282H, ARG141G, ARG144H, ARG202G, ARG202H, ARG210G, ARG217G, ARG259H, ASN231H, ASN251H, ASN266H, ASP170H, ASP185G, ASP187G, ASP192G, ASP269G, ASP269H, ASP270G, ASP270H, CYS152H, CYS169H, GLN183G, GLN203G, GLN203H, GLN206G, GLN223G, GLN226G, GLN226H, GLN245H, GLN256H, GLN258H, GLU138G, GLU211G, GLU249H, GLU281H, GLY189G, GLY193G, GLY194G, GLY196G, GLY205G, GLY205H, GLY216G, GLY228H, GLY243H, GLY271G, GLY271H, HIS135G, HIS163H, HIS166H, HIS225H, ILE143H, ILE151H, ILE212G, ILE250H, LEU137G, LEU165H, LEU171H, LEU173H, LEU200G, LEU200H, LEU215G, LEU261H, LEU267H, LEU268G, LEU268H, LEU285H, LYS148H, LYS182G, LYS207G, LYS253H, LYS262H, MET224H, MET227G, MET227H, MET260H, PHE181H, PHE191G, PHE208G, PHE213G, PHE214G, PHE263H, PHE265H, PHE278H, PHE314H, PRO255H, SER164H, SER190G, SER197G, SER254H, THR172H, THR184G, THR218G, TRP246H, TYR195G, TYR195H, TYR199G, TYR199H, TYR219G, VAL149H, VAL150H, VAL154H, VAL167H, VAL168H, VAL188G, VAL204G, VAL204H, VAL230H, VAL242H, VAL84H
• G-I: ALA186I, ALA198I, ALA201G, ALA201I, ALA209I, ALA229G, ALA232G, ALA247G, ALA248G, ALA252G, ALA257G, ALA264G, ALA282G, ARG141I, ARG144G, ARG202G, ARG202I, ARG210I, ARG217I, ARG259G, ASN231G, ASN251G, ASN266G, ASP170G, ASP185I, ASP187I, ASP192I, ASP269G, ASP269I, ASP270G, ASP270I, CYS152G, CYS169G, GLN183I, GLN203G, GLN203I, GLN206I, GLN223I, GLN226G, GLN226I, GLN245G, GLN256G, GLN258G, GLU138I, GLU211I, GLU249G, GLU281G, GLY189I, GLY193I, GLY194I, GLY196I, GLY205G, GLY205I, GLY216I, GLY228G, GLY243G, GLY271G, GLY271I, HIS135I, HIS163G, HIS166G, HIS225G, ILE143G, ILE151G, ILE212I, ILE250G, LEU137I, LEU165G, LEU171G, LEU173G, LEU200G, LEU200I, LEU215I, LEU261G, LEU267G, LEU268G, LEU268I, LEU285G, LYS148G, LYS182I, LYS207I, LYS253G, LYS262G, MET224G, MET227G, MET227I, MET260G, PHE181G, PHE191I, PHE208I, PHE213I, PHE214I, PHE263G, PHE265G, PHE278G, PHE314G, PRO255G, SER164G, SER190I, SER197I, SER254G, THR172G, THR184I, THR218I, TRP246G, TYR195G, TYR195I, TYR199G, TYR199I, TYR219I, VAL149G, VAL150G, VAL154G, VAL167G, VAL167I, VAL168G, VAL188I, VAL204G, VAL204I, VAL230G, VAL242G, VAL84G
• G-J: ALA186G, ALA186J, ALA198G, ALA198J, ALA201G, ALA201J, ALA279G, ALA279J, ALA282G, ALA282J, ALA286G, ALA286J, ALA292G, ALA292J, ALA298G, ALA298J, ARG141G, ARG141J, ARG144G, ARG144J, ARG202G, ARG202J, ARG284G, ARG284J, ARG296G, ARG296J, ARG77G, ARG77J, ASN266G, ASN266J, ASP106G, ASP106J, ASP185G, ASP185J, ASP187G, ASP187J, ASP192G, ASP192J, ASP269G, ASP269J, ASP270G, ASP270J, ASP297G, ASP297J, ASP74G, ASP74J, GLN140G, GLN140J, GLN203G, GLN203J, GLN206G, GLN206J, GLN275G, GLN275J, GLN276G, GLN276J, GLU138G, GLU138J, GLU281G, GLU281J, GLU291G, GLU291J, GLU294G, GLU294J, GLY105J, GLY189G, GLY189J, GLY193G, GLY193J, GLY194G, GLY194J, GLY196G, GLY196J, GLY271G, GLY271J, GLY274G, GLY274J, GLY280G, GLY280J, GLY295G, GLY295J, HIS135G, HIS135J, ILE136G, ILE136J, ILE143G, ILE143J, LEU137G, LEU137J, LEU142G, LEU142J, LEU200G, LEU200J, LEU267G, LEU267J, LEU268G, LEU268J, LEU272G, LEU272J, LEU277G, LEU277J, LEU285G, LEU285J, LEU300G, LEU300J, MET146G, MET146J, MET78G, MET78J, PHE145G, PHE145J, PHE191G, PHE191J, PHE263G, PHE263J, PHE265G, PHE265J, PHE278G, PHE278J, PHE299G, PHE299J, PRO147G, PRO147J, PRO305G, PRO305J, SER103J, SER190G, SER190J, SER197G, SER197J, THR184G, THR184J, THR283G, THR283J, THR289G, THR289J, TRP307G, TRP307J, TYR195G, TYR195J, TYR199G, TYR199J, TYR287G, TYR287J, TYR70G, TYR70J, VAL139G, VAL139J, VAL167G, VAL167J, VAL168G, VAL168J, VAL188G, VAL188J, VAL273G, VAL273J, VAL293G, VAL293J
• G-K: ALA247K, ALA248K, ALA252G, ALA252K, ALA257G, ALA257K, ALA264G, ALA264K, ALA279G, ALA279K, ALA282G, ALA282K, ALA286G, ALA286K, ALA292G, ALA292K, ALA46G, ALA46K, ALA76G, ALA76K, ARG259G, ARG259K, ARG284G, ARG284K, ARG296G, ARG312G, ARG312K, ARG41G, ARG41K, ARG77G, ARG77K, ASN251G, ASN251K, ASN266G, ASN266K, ASP269G, ASP269K, ASP270G, ASP270K, ASP290G, ASP290K, ASP306G, ASP306K, ASP45G, ASP45K, ASP74G, ASP74K, ASP81G, ASP81K, GLN256G, GLN256K, GLN258G, GLN258K, GLN275G, GLN275K, GLN276G, GLN276K, GLU281G, GLU281K, GLU291G, GLU291K, GLU294G, GLU294K, GLY271G, GLY271K, GLY274G, GLY274K, GLY280G, GLY280K, GLY295G, GLY295K, GLY83G, GLY83K, ILE250G, ILE250K, LEU261G, LEU261K, LEU267G, LEU267K, LEU268G, LEU268K, LEU272G, LEU272K, LEU277G, LEU277K, LEU285G, LEU285K, LYS148G, LYS148K, LYS253G, LYS253K, LYS262G, LYS262K, MET146G, MET146K, MET260G, MET260K, MET288G, MET288K, MET78G, MET78K, PHE145G, PHE145K, PHE263G, PHE263K, PHE265G, PHE265K, PHE278G, PHE278K, PHE310G, PHE310K, PHE314G, PHE314K, PRO147G, PRO147K, PRO255G, PRO255K, PRO304G, PRO304K, PRO305G, PRO305K, PRO309G, PRO309K, PRO311G, PRO311K, PRO80G, PRO80K, SER254G, SER254K, SER308G, SER308K, SER79G, SER79K, THR283G, THR283K, THR289G, THR289K, THR47G, THR47K, TRP307G, TRP307K, TYR287G, TYR287K, TYR313G, TYR313K, VAL149G, VAL149K, VAL273G, VAL273K, VAL293G, VAL293K, VAL82G, VAL82K, VAL84G, VAL84K
• G-L: ARG210G, ARG210L, GLN206G, GLN206L, LEU272G, LEU272L
• H-I: ALA186H, ALA198H, ALA201H, ALA201I, ALA209H, ALA229I, ALA232I, ALA247I, ALA248I, ALA252I, ALA257I, ALA264I, ALA282I, ARG141H, ARG144I, ARG202H, ARG202I, ARG210H, ARG217H, ARG259I, ASN231I, ASN251I, ASN266I, ASP170I, ASP185H, ASP187H, ASP192H, ASP269H, ASP269I, ASP270H, ASP270I, CYS152I, CYS169I, GLN183H, GLN203H, GLN203I, GLN206H, GLN223H, GLN226H, GLN226I, GLN245I, GLN256I, GLN258I, GLU138H, GLU211H, GLU249I, GLU281I, GLY189H, GLY193H, GLY194H, GLY196H, GLY205H, GLY205I, GLY216H, GLY228I, GLY243I, GLY271H, GLY271I, HIS135H, HIS163I, HIS166I, HIS225I, ILE143I, ILE151I, ILE212H, ILE250I, LEU137H, LEU165I, LEU171I, LEU173I, LEU200H, LEU200I, LEU215H, LEU261I, LEU267I, LEU268H, LEU268I, LEU285I, LYS148I, LYS182H, LYS207H, LYS253I, LYS262I, MET224I, MET227H, MET227I, MET260I, PHE181I, PHE191H, PHE208H, PHE213H, PHE214H, PHE263I, PHE265I, PHE278I, PHE314I, PRO255I, SER164I, SER190H, SER197H, SER254I, THR172I, THR184H, THR218H, TRP246I, TYR195H, TYR195I, TYR199H, TYR199I, TYR219H, VAL149I, VAL150I, VAL154I, VAL167I, VAL168I, VAL188H, VAL204H, VAL204I, VAL230I, VAL233I, VAL242I, VAL84I
• H-J: ALA247H, ALA247J, ALA248H, ALA248J, ALA252H, ALA252J, ALA257H, ALA257J, ALA264H, ALA264J, ALA279H, ALA279J, ALA282H, ALA282J, ALA286H, ALA286J, ALA292H, ALA292J, ALA46H, ALA46J, ALA76H, ALA76J, ARG259H, ARG259J, ARG284H, ARG284J, ARG296H, ARG296J, ARG312H, ARG312J, ARG41H, ARG41J, ARG77H, ARG77J, ASN251H, ASN251J, ASN266H, ASN266J, ASP269H, ASP269J, ASP270H, ASP270J, ASP290H, ASP290J, ASP306H, ASP306J, ASP45H, ASP45J, ASP74H, ASP74J, ASP81H, ASP81J, GLN256H, GLN256J, GLN258H, GLN258J, GLN275H, GLN275J, GLN276H, GLN276J, GLU281H, GLU281J, GLU291H, GLU291J, GLU294H, GLU294J, GLY271H, GLY271J, GLY274H, GLY274J, GLY280H, GLY280J, GLY295H, GLY295J, GLY83H, GLY83J, ILE250H, ILE250J, LEU261H, LEU261J, LEU267H, LEU267J, LEU268H, LEU268J, LEU272H, LEU272J, LEU277H, LEU277J, LEU285H, LEU285J, LYS148H, LYS148J, LYS253H, LYS253J, LYS262H, LYS262J, MET146H, MET146J, MET260H, MET260J, MET288H, MET288J, MET78H, MET78J, PHE145H, PHE145J, PHE263H, PHE263J, PHE265H, PHE265J, PHE278H, PHE278J, PHE310H, PHE310J, PHE314H, PHE314J, PRO147H, PRO147J, PRO255H, PRO255J, PRO304H, PRO304J, PRO305H, PRO305J, PRO309H, PRO309J, PRO311H, PRO311J, PRO80H, PRO80J, SER254H, SER254J, SER308H, SER308J, SER79H, SER79J, THR283H, THR283J, THR289H, THR289J, THR47H, THR47J, TRP307H, TRP307J, TYR287H, TYR287J, TYR313H, TYR313J, VAL149H, VAL149J, VAL273H, VAL273J, VAL293H, VAL293J, VAL82H, VAL82J, VAL84H, VAL84J
• H-K: ARG210H, ARG210K, GLN206H, GLN206K, LEU272H, LEU272K
• H-L: ALA186H, ALA186L, ALA198H, ALA198L, ALA201H, ALA201L, ALA279H, ALA279L, ALA282H, ALA282L, ALA286H, ALA286L, ALA292H, ALA292L, ALA298H, ALA298L, ARG141H, ARG141L, ARG144H, ARG144L, ARG202H, ARG202L, ARG284H, ARG284L, ARG296H, ARG296L, ARG58H, ARG58L, ARG77H, ARG77L, ASN266H, ASN266L, ASP106H, ASP106L, ASP185H, ASP185L, ASP187H, ASP187L, ASP192H, ASP192L, ASP269H, ASP269L, ASP270H, ASP270L, ASP297H, ASP297L, ASP74H, ASP74L, GLN140H, GLN140L, GLN203H, GLN203L, GLN206H, GLN206L, GLN275H, GLN275L, GLN276H, GLN276L, GLU138H, GLU138L, GLU281H, GLU281L, GLU291H, GLU291L, GLU294H, GLU294L, GLY105H, GLY105L, GLY189H, GLY189L, GLY193H, GLY193L, GLY194H, GLY194L, GLY196H, GLY196L, GLY271H, GLY271L, GLY274H, GLY274L, GLY280H, GLY280L, GLY295H, GLY295L, HIS135H, HIS135L, ILE136H, ILE136L, ILE143H, ILE143L, LEU137H, LEU137L, LEU142H, LEU142L, LEU200H, LEU200L, LEU267H, LEU267L, LEU268H, LEU268L, LEU272H, LEU272L, LEU277H, LEU277L, LEU285H, LEU285L, LEU300H, LEU300L, MET146H, MET146L, MET78H, MET78L, PHE145H, PHE145L, PHE191H, PHE191L, PHE263H, PHE263L, PHE265H, PHE265L, PHE278H, PHE278L, PHE299H, PHE299L, PRO147H, PRO147L, PRO305H, PRO305L, SER103H, SER103L, SER190H, SER190L, SER197H, SER197L, THR184H, THR184L, THR283H, THR283L, THR289H, THR289L, TRP307H, TRP307L, TYR195H, TYR195L, TYR199H, TYR199L, TYR287H, TYR287L, TYR70H, TYR70L, VAL139H, VAL139L, VAL167H, VAL167L, VAL168H, VAL168L, VAL188H, VAL188L, VAL273H, VAL273L, VAL293H, VAL293L
• I-J: ARG210I, ARG210J, GLN206I, GLN206J, LEU272I, LEU272J
• I-K: ALA186I, ALA186K, ALA198I, ALA198K, ALA201I, ALA201K, ALA279I, ALA279K, ALA282I, ALA282K, ALA286I, ALA286K, ALA292I, ALA292K, ALA298I, ALA298K, ALA60K, ARG141I, ARG141K, ARG144I, ARG144K, ARG202I, ARG202K, ARG284I, ARG284K, ARG296I, ARG296K, ARG58I, ARG58K, ARG77I, ARG77K, ASN266I, ASN266K, ASP106I, ASP106K, ASP185I, ASP185K, ASP187I, ASP187K, ASP192I, ASP192K, ASP269I, ASP269K, ASP270I, ASP270K, ASP297I, ASP297K, ASP74I, ASP74K, GLN140I, GLN140K, GLN203I, GLN203K, GLN206I, GLN206K, GLN275I, GLN275K, GLN276I, GLN276K, GLU138I, GLU138K, GLU281I, GLU281K, GLU291I, GLU291K, GLU294I, GLU294K, GLY105I, GLY105K, GLY189I, GLY189K, GLY193I, GLY193K, GLY194I, GLY194K, GLY196I, GLY196K, GLY271I, GLY271K, GLY274I, GLY274K, GLY280I, GLY280K, GLY295I, GLY295K, HIS135I, HIS135K, ILE136I, ILE136K, ILE143I, ILE143K, LEU137I, LEU137K, LEU142I, LEU142K, LEU200I, LEU200K, LEU267I, LEU267K, LEU268I, LEU268K, LEU272I, LEU272K, LEU277I, LEU277K, LEU285I, LEU285K, LEU300I, LEU300K, MET146I, MET146K, MET78I, MET78K, PHE145I, PHE145K, PHE191I, PHE191K, PHE263I, PHE263K, PHE265I, PHE265K, PHE278I, PHE278K, PHE299I, PHE299K, PRO147I, PRO147K, PRO305I, PRO305K, SER103I, SER103K, SER190I, SER190K, SER197I, SER197K, THR184I, THR184K, THR283I, THR283K, THR289I, THR289K, TRP307I, TRP307K, TYR195I, TYR195K, TYR199I, TYR199K, TYR287I, TYR287K, TYR70I, TYR70K, VAL139I, VAL139K, VAL167I, VAL167K, VAL168I, VAL168K, VAL188I, VAL188K, VAL273I, VAL273K, VAL293I, VAL293K
• I-L: ALA247I, ALA247L, ALA248I, ALA248L, ALA252I, ALA252L, ALA257I, ALA257L, ALA264I, ALA264L, ALA279I, ALA279L, ALA282I, ALA282L, ALA286I, ALA286L, ALA292I, ALA292L, ALA46I, ALA46L, ALA76I, ALA76L, ARG259I, ARG259L, ARG284I, ARG284L, ARG296I, ARG296L, ARG312I, ARG312L, ARG41I, ARG41L, ARG77I, ARG77L, ASN251I, ASN251L, ASN266I, ASN266L, ASP269I, ASP269L, ASP270I, ASP270L, ASP290I, ASP290L, ASP306I, ASP306L, ASP45I, ASP45L, ASP74I, ASP74L, ASP81I, ASP81L, GLN256I, GLN256L, GLN258I, GLN258L, GLN275I, GLN275L, GLN276I, GLN276L, GLU281I, GLU281L, GLU291I, GLU291L, GLU294I, GLU294L, GLY271I, GLY271L, GLY274I, GLY274L, GLY280I, GLY280L, GLY295I, GLY295L, GLY83I, GLY83L, ILE250I, ILE250L, LEU261I, LEU261L, LEU267I, LEU267L, LEU268I, LEU268L, LEU272I, LEU272L, LEU277I, LEU277L, LEU285I, LEU285L, LYS148I, LYS148L, LYS253I, LYS253L, LYS262I, LYS262L, MET146I, MET146L, MET260I, MET260L, MET288I, MET288L, MET78I, MET78L, PHE145I, PHE145L, PHE263I, PHE263L, PHE265I, PHE265L, PHE278I, PHE278L, PHE310I, PHE310L, PHE314I, PHE314L, PRO147I, PRO147L, PRO255I, PRO255L, PRO304I, PRO304L, PRO305I, PRO305L, PRO309I, PRO309L, PRO311I, PRO311L, PRO80I, PRO80L, SER254I, SER254L, SER308I, SER308L, SER79I, SER79L, THR283I, THR283L, THR289I, THR289L, THR47I, THR47L, TRP307I, TRP307L, TYR287I, TYR287L, TYR313I, TYR313L, VAL149I, VAL149L, VAL273I, VAL273L, VAL293I, VAL293L, VAL82I, VAL82L, VAL84I, VAL84L
• J-K: ALA186J, ALA198J, ALA201J, ALA201K, ALA209J, ALA229K, ALA232K, ALA247K, ALA248K, ALA252K, ALA257K, ALA264K, ALA282K, ARG141J, ARG144K, ARG202J, ARG202K, ARG210J, ARG217J, ARG259K, ASN231K, ASN251K, ASN266K, ASP170K, ASP185J, ASP187J, ASP192J, ASP269J, ASP269K, ASP270J, ASP270K, CYS152K, CYS169K, GLN183J, GLN203J, GLN203K, GLN206J, GLN223J, GLN226J, GLN226K, GLN245K, GLN256K, GLN258K, GLU138J, GLU211J, GLU249K, GLU281K, GLY189J, GLY193J, GLY194J, GLY196J, GLY205J, GLY205K, GLY216J, GLY228K, GLY243K, GLY271J, GLY271K, HIS135J, HIS163K, HIS166K, HIS225K, ILE143K, ILE151K, ILE212J, ILE250K, LEU137J, LEU165K, LEU171K, LEU173K, LEU200J, LEU200K, LEU215J, LEU261K, LEU267K, LEU268J, LEU268K, LEU285K, LYS148K, LYS182J, LYS207J, LYS253K, LYS262K, MET224K, MET227J, MET227K, MET260K, PHE181K, PHE191J, PHE208J, PHE213J, PHE214J, PHE263K, PHE265K, PHE278K, PHE314K, PRO255K, SER164K, SER190J, SER197J, SER254K, THR172K, THR184J, THR218J, TRP246K, TYR195J, TYR195K, TYR199J, TYR199K, TYR219J, VAL149K, VAL150K, VAL154K, VAL167K, VAL168K, VAL188J, VAL204J, VAL204K, VAL230K, VAL233K, VAL242K, VAL84K
• J-L: ALA186L, ALA198L, ALA201J, ALA201L, ALA209L, ALA229J, ALA232J, ALA247J, ALA248J, ALA252J, ALA257J, ALA264J, ALA282J, ARG141L, ARG144J, ARG202J, ARG202L, ARG210L, ARG217L, ARG259J, ASN231J, ASN251J, ASN266J, ASP170J, ASP185L, ASP187L, ASP192L, ASP269J, ASP269L, ASP270J, ASP270L, CYS152J, CYS169J, GLN183L, GLN203J, GLN203L, GLN206L, GLN223L, GLN226J, GLN226L, GLN245J, GLN256J, GLN258J, GLU138L, GLU211L, GLU249J, GLU281J, GLY189L, GLY193L, GLY194L, GLY196L, GLY205J, GLY205L, GLY216L, GLY228J, GLY243J, GLY271J, GLY271L, HIS135L, HIS163J, HIS166J, HIS225J, ILE143J, ILE151J, ILE212L, ILE250J, LEU137L, LEU165J, LEU171J, LEU173J, LEU200J, LEU200L, LEU215L, LEU261J, LEU267J, LEU268J, LEU268L, LEU285J, LYS148J, LYS182L, LYS207L, LYS253J, LYS262J, MET224J, MET227J, MET227L, MET260J, PHE181J, PHE191L, PHE208L, PHE213L, PHE214L, PHE263J, PHE265J, PHE278J, PHE314J, PRO255J, SER164J, SER190L, SER197L, SER254J, THR172J, THR184L, THR218L, TRP246J, TYR195J, TYR199J, TYR199L, TYR219L, VAL149J, VAL150J, VAL154J, VAL167J, VAL168J, VAL188L, VAL204J, VAL204L, VAL230J, VAL242J, VAL84J
• K-L: ALA186K, ALA198K, ALA201K, ALA201L, ALA209K, ALA229L, ALA232L, ALA247L, ALA248L, ALA252L, ALA257L, ALA264L, ALA282L, ARG141K, ARG144L, ARG202K, ARG202L, ARG210K, ARG217K, ARG259L, ASN231L, ASN251L, ASN266L, ASP170L, ASP185K, ASP187K, ASP192K, ASP269K, ASP269L, ASP270K, ASP270L, CYS152L, CYS169L, GLN183K, GLN203K, GLN203L, GLN206K, GLN223K, GLN226K, GLN226L, GLN245L, GLN256L, GLN258L, GLU138K, GLU211K, GLU249L, GLU281L, GLY189K, GLY193K, GLY194K, GLY196K, GLY205K, GLY205L, GLY216K, GLY228L, GLY243L, GLY271K, GLY271L, HIS135K, HIS163L, HIS166L, HIS225L, ILE143L, ILE151L, ILE212K, ILE250L, LEU137K, LEU165L, LEU171L, LEU173L, LEU200K, LEU200L, LEU215K, LEU261L, LEU267L, LEU268K, LEU268L, LEU285L, LYS148L, LYS182K, LYS207K, LYS253L, LYS262L, MET224L, MET227K, MET227L, MET260L, PHE181L, PHE191K, PHE208K, PHE213K, PHE214K, PHE263L, PHE265L, PHE278L, PHE314L, PRO255L, SER164L, SER190K, SER197K, SER254L, THR172L, THR184K, THR218K, TRP246L, TYR195L, TYR199K, TYR199L, TYR219K, VAL149L, VAL150L, VAL154L, VAL167L, VAL168L, VAL188K, VAL204K, VAL204L, VAL230L, VAL242L, VAL84L