1PTO

the structure of a pertussis toxin-sugar complex as a model for receptor binding

• Total interactions analyzed: 66
• Total true interactions: 31
• Strongest Interaction:
  • Chains: I-K
  • Int. Res.: 124
  • Norm. En. per Res.: -4.0616
• Hub Node: B(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	0.0	0.0	-40.7037	-40.7037	27	3	2	2097	0	1	0
A-C	0.0	0.0	-68.7814	-68.7814	42	3	1	3460	0	2	1
A-D	-4.4486	0.0	-105.581	-110.0296	54	6	0	4473	0	8	4
A-E	-34.5979	14.8661	-128.471	-148.2028	77	18	4	5908	0	12	8
A-F	-21.9308	-26.1981	-128.879	-177.0079	63	5	7	5738	4	8	9
B-C	0.0	0.0	-0.8738	-0.8738	7	0	0	106	0	1	2
B-D	-93.1963	-44.5448	-362.348	-500.0891	128	36	13	15468	6	22	25
B-E	0.0	0.0	-0.002	-0.002	5	0	0	6	0	0	1
B-F	-62.0622	-52.3141	-247.06	-361.4362	93	22	8	10486	3	15	10
B-H	0.0	10.9528	-11.3898	-0.437	12	0	0	443	0	2	4
B-J	-3.15	-7.6882	-69.1443	-79.9825	29	11	0	2962	0	5	7
C-D	-26.2629	-27.7288	-159.079	-213.0707	83	12	5	7916	3	21	19
C-E	-51.4117	-59.8236	-360.494	-471.7293	122	23	12	15352	7	22	24
C-F	0.0	0.0	-0.0151	-0.0151	5	0	0	14	0	1	1
D-E	0.0	0.0	-3.2084	-3.2084	7	0	0	192	0	0	2
D-H	-3.5255	-6.9934	-67.5485	-78.0673	28	2	0	2682	0	5	6
E-F	-52.7158	-21.4949	-202.816	-277.0267	79	11	2	8040	3	24	15
G-H	0.0	0.0	-40.1471	-40.1471	27	1	1	2063	0	1	0
G-I	-2.3549	0.0	-70.3323	-72.6872	42	3	1	3532	0	2	1
G-J	-4.1654	0.0	-101.499	-105.6644	54	10	0	4522	0	8	4
G-K	-28.7481	11.9724	-109.778	-126.5537	75	22	4	5918	0	12	10
G-L	-21.7738	-22.2242	-124.072	-168.07	64	7	7	5709	3	8	8
H-I	0.0	0.0	-0.7966	-0.7966	7	0	0	97	0	1	2
H-J	-87.5391	-50.4789	-344.646	-482.6641	128	33	13	15579	8	22	26
H-K	0.0	0.0	-0.0016	-0.0016	5	0	0	5	0	0	1
H-L	-51.7873	-29.1184	-235.256	-316.1617	93	22	6	10469	3	15	10
I-J	-40.6299	-31.3255	-170.454	-242.4094	83	12	5	8081	3	21	21
I-K	-79.8964	-56.6035	-367.135	-503.6349	124	21	12	15445	7	22	25
I-L	0.0	0.0	-0.0183	-0.0183	5	0	0	17	0	1	1
J-K	0.0	0.0	-3.0623	-3.0623	7	0	0	190	0	0	2
K-L	-33.5729	-19.605	-199.124	-252.3019	79	15	2	8230	2	24	15

Interface residues

• A-B: ALA159B, ALA232A, ARG117A, ARG150B, GLU229A, GLY160B, GLY189A, ILE156B, ILE161B, ILE191B, ILE231A, LEU119A, LEU153B, LEU155B, LYS151B, MET152B, PHE235A, SER230A, SER234A, TYR154B, TYR157B, TYR227A, TYR228A, TYR233A, VAL158B, VAL188A, VAL226A
• A-C: ALA120A, ALA122A, ALA124A, ALA148C, ALA162C, ALA195A, ALA195C, ALA232A, ARG150C, ARG151C, ASP109A, GLN127A, GLU229A, GLY121A, GLY160C, ILE118A, ILE156C, ILE231A, LEU119A, LEU123A, LEU152C, LEU153C, LEU161C, LEU191C, MET155C, MET158C, MET194A, PHE105A, PHE235A, PRO194C, PRO196A, SER159C, SER234A, THR107C, THR125A, TYR126A, TYR154C, TYR157C, TYR228A, TYR233A, VAL192A, VAL197A
• A-D: ALA115A, ALA120A, ALA122A, ALA17D, ALA232A, ALA35D, ALA41D, ALA46D, ALA70D, ARG117A, ARG182A, ARG69D, ARG76D, ASN10D, ASN114A, ASP109A, ASP113A, GLN74D, GLN75D, GLU229A, GLY112A, GLY116A, GLY189A, GLY38D, ILE118A, ILE187A, ILE231A, LEU119A, LEU37D, LEU68D, LEU78D, LYS36D, MET11D, MET18D, MET73D, PHE235A, PHE72D, PRO77D, SER15D, SER230A, SER234A, THR14D, THR190A, TYR104A, TYR111A, TYR227A, TYR228A, TYR233A, VAL108A, VAL12D, VAL13D, VAL16D, VAL188A, VAL71D
• A-E: ALA195A, ALA232A, ALA34E, ALA35E, ALA39E, ALA40E, ALA41E, ALA46E, ALA70E, ALA71A, ARG193A, ARG58A, ARG67A, ARG69E, ARG76A, ARG76E, ASN10E, ASN150A, ASP45E, GLN69A, GLN74E, GLN75E, GLU155A, GLU65A, GLU70A, GLU73A, GLU75A, GLY105E, GLY151A, GLY154A, GLY38E, GLY82A, HIS149A, HIS47E, HIS66A, ILE152A, ILE231A, ILE33E, LEU123A, LEU37E, LEU64A, LYS106E, LYS36E, MET11E, MET194A, MET68A, MET73E, PHE235A, PHE72E, PRO196A, PRO44E, PRO49E, PRO77E, SER104E, SER15E, SER230A, SER234A, SER42E, SER43E, SER61E, THR14E, THR153A, THR156A, TYR126A, TYR228A, TYR233A, TYR59A, VAL12E, VAL13E, VAL197A, VAL198A, VAL226A, VAL48E, VAL62A, VAL66E, VAL71E, VAL72A
• A-F: ALA195A, ALA203A, ALA222A, ALA60F, ALA63F, ALA65F, ALA74A, ALA77A, ARG193A, ARG67A, ARG69F, ARG76A, ARG79A, ASN95F, ASN9F, ASP54F, CYS92F, CYS98F, GLN42A, GLU221A, GLU229A, GLU70A, GLU73A, GLU75A, GLU99F, GLY58F, GLY78A, GLY80A, GLY96F, HIS66A, ILE231A, ILE61F, LEU15F, LEU191A, LEU225A, LEU57F, LEU66F, LEU94F, LYS67F, LYS8F, MET194A, MET223A, MET32F, PHE235A, PHE59F, PRO196A, PRO93F, SER230A, SER234A, SER62F, SER68F, THR11F, THR55F, TYR227A, TYR63A, TYR64F, TYR97F, VAL192A, VAL197A, VAL198A, VAL224A, VAL226A, VAL72A
• B-C: ARG150B, ARG150C, ARG151C, ASP147C, LYS151B, MET155C, TYR154B
• B-D: ALA108B, ALA121B, ALA159B, ALA24B, ALA29B, ALA70D, ALA79B, ARG110B, ARG118B, ARG150B, ARG22B, ARG27D, ARG28B, ARG58D, ARG69D, ARG76D, ARG79D, ARG99D, ASN116B, ASN25B, ASP108D, ASP139B, ASP175B, ASP178B, ASP1D, ASP55D, ASP59B, ASP81B, CYS103D, CYS109D, CYS120B, CYS134B, CYS23B, CYS51D, GLN107D, GLN74D, GLN75D, GLU102D, GLU177B, GLU65D, GLU96D, GLY105D, GLY160B, GLY21B, GLY53D, GLY60D, GLY77B, GLY78B, GLY83D, ILE156B, ILE88B, ILE98D, LEU111B, LEU112B, LEU119B, LEU149B, LEU153B, LEU155B, LEU68D, LEU6D, LEU78D, LEU82B, LEU82D, LEU97D, LYS106D, LYS151B, LYS26B, LYS36D, LYS54D, LYS83B, LYS85D, LYS8D, MET100D, MET64D, MET67D, MET73D, MET80D, PHE181B, PHE52D, PHE72D, PHE80B, PHE81D, PRO110D, PRO129B, PRO137B, PRO19B, PRO3D, PRO59D, PRO63D, PRO76B, PRO77D, PRO84D, SER104D, SER113B, SER114B, SER117B, SER136B, SER147B, SER61D, SER62D, THR109B, THR115B, THR135B, THR180B, THR27B, THR31B, THR75B, THR85B, THR90B, THR9D, TRP143B, TYR138B, TYR146B, TYR154B, TYR157B, TYR174B, TYR176B, TYR20B, TYR4D, TYR58B, VAL101D, VAL122B, VAL158B, VAL2D, VAL5D, VAL66D, VAL71D, VAL7D
• B-E: ARG150B, GLY60E, LYS151B, PRO59E, SER61E
• B-F: ALA159B, ALA16F, ALA30F, ALA40F, ALA45F, ALA60F, ALA65F, ALA98B, ARG148B, ARG150B, ARG164B, ARG39F, ASN193B, ASN23F, ASP100B, ASP44F, ASP50F, ASP54F, CYS192B, CYS199B, CYS27F, CYS41F, GLN13F, GLN24F, GLU14F, GLU25F, GLU48F, GLY188B, GLY195B, GLY21F, GLY58F, GLY81F, HIS166B, HIS49F, ILE156B, ILE161B, ILE189B, ILE191B, ILE61F, LEU149B, LEU153B, LEU155B, LEU15F, LEU17F, LEU186B, LEU198B, LEU19F, LEU28F, LEU37F, LEU42F, LEU57F, LEU66F, LYS141B, LYS151B, LYS18F, LYS20F, LYS22F, LYS67F, MET145B, MET152B, MET56F, PHE26F, PHE31F, PHE53F, PHE59F, PRO194B, PRO83F, SER144B, SER147B, SER162B, SER168B, SER190B, SER196B, SER197B, SER43F, SER62F, THR187B, THR29F, THR51F, THR55F, THR82F, TRP143B, TRP52F, TYR102B, TYR142B, TYR146B, TYR154B, TYR64F, VAL12F, VAL163B, VAL165B, VAL167B, VAL38F
• B-H: ARG22B, ARG22H, ASP81B, ASP81H, LEU82B, LEU82H, LYS83B, LYS83H, PRO19B, PRO19H, TYR20B, TYR20H
• B-J: ALA94J, ARG50B, ASP1J, ASP81B, GLN86J, GLU66B, GLU90J, GLY51B, GLY83J, GLY91J, ILE54B, LEU82B, LEU87J, LYS83B, LYS85J, LYS92J, PHE80B, PHE89J, PRO3J, PRO84J, PRO93J, SER53B, THR84B, THR88J, TRP52B, TYR4J, TYR67B, VAL2J, VAL5J
• C-D: ALA148C, ALA17D, ALA195C, ALA196C, ALA34D, ALA35D, ALA41D, ALA46D, ARG141C, ARG143C, ARG150C, ARG151C, ARG164C, ARG27D, ARG58D, ARG69D, ASN193C, ASP100C, ASP144C, ASP147C, ASP55D, CYS192C, CYS199C, CYS31D, GLU22D, GLU65D, GLU90D, GLY188C, GLY32D, GLY60D, GLY91D, HIS166C, HIS47D, ILE156C, ILE189C, ILE198C, ILE33D, LEU149C, LEU152C, LEU153C, LEU161C, LEU186C, LEU191C, LEU29D, LEU56D, LYS19D, LYS54D, LYS57D, LYS92D, MET145C, MET155C, MET18D, MET28D, MET73D, PHE72D, PHE89D, PRO194C, PRO20D, PRO25D, PRO49D, PRO59D, SER159C, SER15D, SER168C, SER190C, SER197C, SER61D, SER62D, THR14D, THR187C, THR24D, THR26D, TYR102C, TYR142C, TYR146C, TYR21D, VAL13D, VAL163C, VAL165C, VAL16D, VAL30D, VAL48D, VAL66D
• C-E: ALA108C, ALA113C, ALA121C, ALA135C, ALA19C, ALA29C, ALA70E, ALA78C, ARG110C, ARG118C, ARG143C, ARG150C, ARG151C, ARG22C, ARG27E, ARG28C, ARG58E, ARG69E, ARG76E, ARG79E, ARG83C, ARG99E, ASN116C, ASN25C, ASP108E, ASP147C, ASP175C, ASP178C, ASP55E, ASP59C, CYS103E, CYS109E, CYS120C, CYS23C, GLN107E, GLN74E, GLN75E, GLU102E, GLU139C, GLU177C, GLU65E, GLU96E, GLY105E, GLY160C, GLY21C, GLY26C, GLY53E, GLY60E, GLY77C, GLY79C, GLY83E, ILE81C, ILE98E, LEU111C, LEU112C, LEU119C, LEU149C, LEU152C, LEU153C, LEU57C, LEU68E, LEU6E, LEU78E, LEU82E, LEU97E, LYS36E, LYS54E, LYS85E, LYS8E, MET100E, MET155C, MET158C, MET64E, MET67E, MET73E, MET80E, PHE181C, PHE52E, PHE72E, PHE80C, PHE81E, PRO110E, PRO137C, PRO24C, PRO3E, PRO59E, PRO63E, PRO75C, PRO76C, PRO77E, PRO84E, SER104E, SER114C, SER117C, SER136C, SER159C, SER61E, SER62E, THR109C, THR115C, THR27C, THR31C, THR85C, THR90C, THR9E, TYR138C, TYR146C, TYR154C, TYR157C, TYR174C, TYR176C, TYR20C, TYR4E, TYR58C, TYR82C, VAL101E, VAL122C, VAL2E, VAL5E, VAL66E, VAL71E, VAL7E
• C-F: LEU66F, LEU94F, MET158C, SER62F, TYR154C
• D-E: ARG58D, ARG58E, GLY60D, GLY60E, LYS57D, PRO59D, PRO59E
• D-H: ALA94D, ARG50H, ASP1D, ASP81H, GLN86D, GLU66H, GLU90D, GLY51H, GLY83D, GLY91D, ILE54H, LEU82H, LEU87D, LYS83H, LYS85D, LYS92D, PHE89D, PRO3D, PRO84D, PRO93D, SER53H, THR84H, THR88D, TRP52H, TYR4D, TYR67H, VAL2D, VAL5D
• E-F: ALA17E, ALA35E, ALA46E, ALA60F, ALA63F, ALA65F, ALA71F, ARG27E, ARG58E, ARG69E, ARG69F, ASN95F, ASP50F, ASP54F, ASP55E, CYS31E, CYS92F, CYS98F, GLN74E, GLN75E, GLN90F, GLU48F, GLU65E, GLU88F, GLU90E, GLU99F, GLY32E, GLY58F, GLY60E, GLY91E, GLY96F, HIS47E, HIS47F, HIS49F, ILE33E, ILE61F, ILE70F, ILE91F, LEU29E, LEU42F, LEU56E, LEU66F, LEU68E, LEU6F, LEU86F, LEU87F, LEU89F, LEU94F, LYS19E, LYS54E, LYS57E, LYS8F, MET18E, MET28E, MET56F, MET73E, PHE53F, PHE59F, PHE72E, PHE89E, PRO20E, PRO25E, PRO59E, PRO93F, SER15E, SER61E, SER62F, SER68F, THR14E, THR26E, THR51F, THR55F, THR73F, TRP52F, TYR21E, TYR97F, VAL13E, VAL16E, VAL30E
• G-H: ALA159H, ALA232G, ARG117G, ARG150H, GLU229G, GLY160H, GLY189G, ILE156H, ILE161H, ILE191H, ILE231G, LEU119G, LEU153H, LEU155H, LYS151H, MET152H, PHE235G, SER230G, SER234G, TYR154H, TYR157H, TYR227G, TYR228G, TYR233G, VAL158H, VAL188G, VAL226G
• G-I: ALA120G, ALA122G, ALA124G, ALA148I, ALA162I, ALA195G, ALA195I, ALA232G, ARG150I, ARG151I, ASP109G, GLN127G, GLU229G, GLY121G, GLY160I, ILE118G, ILE156I, ILE231G, LEU119G, LEU123G, LEU152I, LEU153I, LEU161I, LEU191I, MET155I, MET158I, MET194G, PHE105G, PHE235G, PRO194I, PRO196G, SER159I, SER234G, THR107I, THR125G, TYR126G, TYR154I, TYR157I, TYR228G, TYR233G, VAL192G, VAL197G
• G-J: ALA115G, ALA120G, ALA122G, ALA232G, ALA35J, ALA41J, ALA46J, ALA70J, ARG117G, ARG182G, ARG69J, ARG76J, ASN10J, ASN114G, ASP109G, ASP113G, GLN74J, GLN75J, GLU229G, GLY112G, GLY116G, GLY189G, GLY38J, ILE118G, ILE187G, ILE231G, LEU119G, LEU37J, LEU68J, LEU78J, LYS36J, MET11J, MET18J, MET73J, PHE235G, PHE72J, PRO77J, SER15J, SER230G, SER234G, SER61J, THR14J, THR190G, TYR104G, TYR111G, TYR227G, TYR228G, TYR233G, VAL108G, VAL12J, VAL13J, VAL16J, VAL188G, VAL71J
• G-K: ALA195G, ALA232G, ALA35K, ALA39K, ALA40K, ALA41K, ALA46K, ALA70K, ALA71G, ARG193G, ARG58G, ARG67G, ARG69K, ARG76G, ARG76K, ASN10K, ASN150G, ASP45K, GLN69G, GLN74K, GLN75K, GLU155G, GLU65G, GLU70G, GLU73G, GLU75G, GLY105K, GLY151G, GLY154G, GLY38K, GLY82G, HIS149G, HIS47K, HIS66G, ILE152G, ILE231G, ILE33K, LEU123G, LEU37K, LYS106K, LYS36K, MET11K, MET194G, MET68G, MET73K, PHE235G, PHE72K, PRO196G, PRO44K, PRO49K, PRO77K, SER104K, SER15K, SER230G, SER234G, SER42K, SER43K, SER61K, THR14K, THR153G, THR156G, TYR126G, TYR228G, TYR233G, TYR59G, VAL12K, VAL13K, VAL197G, VAL198G, VAL226G, VAL48K, VAL62G, VAL66K, VAL71K, VAL72G
• G-L: ALA195G, ALA222G, ALA60L, ALA63L, ALA65L, ALA74G, ALA77G, ARG193G, ARG67G, ARG69L, ARG76G, ARG79G, ASN95L, ASN9L, ASP54L, CYS98L, GLN69G, GLU221G, GLU229G, GLU70G, GLU73G, GLU75G, GLU99L, GLY58L, GLY78G, GLY80G, GLY96L, HIS66G, ILE231G, ILE61L, LEU15L, LEU191G, LEU225G, LEU57L, LEU66L, LEU94L, LYS67L, LYS8L, MET194G, MET223G, MET32L, PHE235G, PHE59L, PRO196G, PRO93L, SER230G, SER234G, SER62L, SER68L, THR11L, THR55L, TYR227G, TYR228G, TYR233G, TYR63G, TYR64L, TYR97L, VAL192G, VAL197G, VAL198G, VAL224G, VAL226G, VAL43G, VAL72G
• H-I: ARG150H, ARG150I, ARG151I, ASP147I, LYS151H, MET155I, TYR154H
• H-J: ALA108H, ALA121H, ALA159H, ALA24H, ALA29H, ALA70J, ALA79H, ARG110H, ARG118H, ARG150H, ARG22H, ARG27J, ARG28H, ARG58J, ARG69J, ARG76J, ARG79J, ARG99J, ASN116H, ASN25H, ASP108J, ASP139H, ASP175H, ASP178H, ASP1J, ASP55J, ASP59H, ASP81H, CYS103J, CYS109J, CYS120H, CYS134H, CYS23H, GLN107J, GLN74J, GLN75J, GLU102J, GLU177H, GLU65J, GLU96J, GLY105J, GLY160H, GLY21H, GLY53J, GLY60J, GLY77H, GLY78H, GLY83J, ILE156H, ILE88H, ILE98J, LEU111H, LEU112H, LEU119H, LEU149H, LEU153H, LEU155H, LEU68J, LEU6J, LEU78J, LEU82H, LEU82J, LEU97J, LYS106J, LYS151H, LYS26H, LYS36J, LYS54J, LYS83H, LYS85J, LYS8J, MET100J, MET64J, MET67J, MET73J, MET80J, PHE181H, PHE52J, PHE72J, PHE80H, PHE81J, PRO110J, PRO129H, PRO137H, PRO19H, PRO3J, PRO59J, PRO63J, PRO76H, PRO77J, PRO84J, SER104J, SER113H, SER114H, SER117H, SER136H, SER147H, SER61J, SER62J, THR109H, THR115H, THR135H, THR180H, THR27H, THR2H, THR31H, THR75H, THR85H, THR90H, THR9J, TRP143H, TYR138H, TYR146H, TYR154H, TYR157H, TYR174H, TYR176H, TYR20H, TYR4J, TYR58H, VAL101J, VAL122H, VAL158H, VAL2J, VAL5J, VAL66J, VAL71J, VAL7J
• H-K: ARG150H, ARG69K, GLY60K, LYS151H, PRO59K
• H-L: ALA159H, ALA16L, ALA30L, ALA40L, ALA45L, ALA60L, ALA65L, ALA98H, ARG148H, ARG150H, ARG164H, ARG39L, ASN193H, ASN23L, ASP100H, ASP44L, ASP50L, ASP54L, CYS192H, CYS199H, CYS27L, CYS41L, GLN13L, GLN24L, GLU14L, GLU25L, GLU48L, GLY188H, GLY195H, GLY21L, GLY58L, GLY81L, HIS166H, HIS49L, ILE156H, ILE161H, ILE189H, ILE191H, ILE61L, LEU149H, LEU153H, LEU155H, LEU15L, LEU17L, LEU186H, LEU198H, LEU19L, LEU28L, LEU37L, LEU42L, LEU57L, LEU66L, LYS141H, LYS151H, LYS18L, LYS20L, LYS22L, LYS67L, MET145H, MET152H, MET56L, PHE26L, PHE31L, PHE53L, PHE59L, PRO194H, PRO83L, SER144H, SER147H, SER162H, SER168H, SER190H, SER196H, SER197H, SER43L, SER62L, THR187H, THR29L, THR51L, THR55L, THR82L, TRP143H, TRP52L, TYR102H, TYR142H, TYR146H, TYR154H, TYR64L, VAL12L, VAL163H, VAL165H, VAL167H, VAL38L
• I-J: ALA148I, ALA162I, ALA17J, ALA195I, ALA196I, ALA34J, ALA35J, ALA41J, ALA46J, ARG141I, ARG143I, ARG150I, ARG151I, ARG164I, ARG27J, ARG58J, ARG69J, ASN193I, ASP100I, ASP144I, ASP147I, ASP55J, CYS192I, CYS199I, CYS31J, GLU22J, GLU65J, GLU90J, GLY188I, GLY32J, GLY60J, GLY91J, HIS166I, HIS47J, ILE156I, ILE189I, ILE198I, ILE33J, LEU149I, LEU152I, LEU153I, LEU161I, LEU186I, LEU191I, LEU29J, LEU56J, LYS19J, LYS54J, LYS57J, LYS92J, MET145I, MET155I, MET18J, MET28J, MET73J, PHE72J, PHE89J, PRO194I, PRO20J, PRO25J, PRO49J, PRO59J, SER104I, SER159I, SER15J, SER168I, SER190I, SER197I, SER61J, SER62J, THR14J, THR187I, THR24J, THR26J, TYR102I, TYR142I, TYR146I, TYR21J, VAL13J, VAL163I, VAL16J, VAL30J, VAL48J
• I-K: ALA108I, ALA113I, ALA121I, ALA135I, ALA19I, ALA29I, ALA70K, ALA78I, ARG110I, ARG118I, ARG143I, ARG150I, ARG151I, ARG22I, ARG27K, ARG28I, ARG58K, ARG69K, ARG76K, ARG79K, ARG83I, ARG99K, ASN116I, ASN25I, ASP108K, ASP147I, ASP175I, ASP178I, ASP55K, ASP59I, CYS103K, CYS109K, CYS120I, CYS134I, CYS23I, GLN107K, GLN74K, GLN75K, GLU102K, GLU139I, GLU177I, GLU65K, GLU96K, GLY105K, GLY160I, GLY21I, GLY26I, GLY53K, GLY60K, GLY77I, GLY79I, GLY83K, ILE81I, ILE98K, LEU111I, LEU112I, LEU119I, LEU149I, LEU152I, LEU153I, LEU57I, LEU68K, LEU6K, LEU78K, LEU82K, LEU97K, LYS36K, LYS54K, LYS85K, LYS8K, MET100K, MET155I, MET158I, MET64K, MET67K, MET73K, MET80K, PHE181I, PHE52K, PHE72K, PHE80I, PHE81K, PRO110K, PRO137I, PRO24I, PRO3K, PRO59K, PRO63K, PRO75I, PRO76I, PRO77K, PRO84K, SER104K, SER114I, SER117I, SER129I, SER136I, SER159I, SER61K, SER62K, THR109I, THR115I, THR27I, THR31I, THR85I, THR90I, THR9K, TYR138I, TYR146I, TYR154I, TYR157I, TYR174I, TYR176I, TYR20I, TYR4K, TYR58I, TYR82I, VAL101K, VAL122I, VAL2K, VAL5K, VAL66K, VAL71K, VAL7K
• I-L: LEU66L, LEU94L, MET158I, SER62L, TYR154I
• J-K: ARG58J, ARG58K, GLY60J, GLY60K, LYS57J, PRO59J, PRO59K
• K-L: ALA17K, ALA46K, ALA60L, ALA63L, ALA65L, ALA71L, ARG27K, ARG58K, ARG69K, ARG69L, ASN95L, ASP50L, ASP54L, ASP55K, CYS31K, CYS92L, CYS98L, GLN74K, GLN75K, GLN90L, GLU48L, GLU65K, GLU88L, GLU90K, GLU99L, GLY32K, GLY58L, GLY60K, GLY91K, GLY96L, HIS47K, HIS47L, HIS49L, ILE33K, ILE70L, ILE91L, LEU29K, LEU42L, LEU56K, LEU66L, LEU68K, LEU6L, LEU86L, LEU87L, LEU89L, LEU94L, LYS19K, LYS54K, LYS57K, LYS8L, MET18K, MET28K, MET56L, MET73K, PHE53L, PHE59L, PHE72K, PHE89K, PRO20K, PRO25K, PRO59K, PRO93L, SER15K, SER61K, SER62K, SER62L, SER68L, THR14K, THR26K, THR51L, THR55L, THR73L, TRP52L, TYR21K, TYR97L, VAL12K, VAL13K, VAL16K, VAL30K