1PQ3

human arginase ii: crystal structure and physiological role in male and female sexual arousal

• Total interactions analyzed: 15
• Total true interactions: 9
• Strongest Interaction:
  • Chains: E-F
  • Int. Res.: 73
  • Norm. En. per Res.: -4.269
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-32.5224	-96.3967	-165.79	-294.7092	77	16	1	6651	8	33	39
A-C	-29.199	-81.8136	-149.254	-260.2666	72	11	1	6199	9	33	35
B-C	-36.5771	-112.7858	-161.205	-310.5679	73	14	1	6459	10	34	36
B-F	-16.1007	-12.0972	-96.9138	-125.1117	44	22	0	4335	1	12	12
C-E	-20.2749	-12.074	-95.1428	-127.4917	44	23	0	4342	1	12	12
C-F	0.0	3.0356	-68.6141	-65.5785	54	0	2	3350	0	12	6
D-E	-33.0062	-96.5253	-168.228	-297.7595	77	15	1	6690	8	33	39
D-F	-29.6616	-81.8993	-152.098	-263.6589	72	9	1	6215	9	33	35
E-F	-36.7939	-113.303	-161.54	-311.6369	73	12	1	6446	10	34	36

Interface residues

• A-B: ALA144B, ALA146B, ALA280A, ARG199B, ARG220B, ARG224B, ARG274A, ARG274B, ARG327A, ARG57A, ASN285A, ASN313A, ASP200B, ASP202B, ASP221B, ASP223B, ASP256B, ASP317A, GLN228A, GLN325A, GLU205B, GLU232A, GLU275A, GLU275B, GLU281A, GLU282A, GLU306A, GLU307B, GLU328A, GLY197B, GLY226A, GLY226B, GLY269B, GLY270B, GLY276A, GLY276B, GLY329A, HIS145B, HIS206B, HIS284A, ILE222B, ILE227A, ILE227B, ILE279A, ILE283A, LEU198B, LEU209B, LEU225B, LEU259A, LEU271B, LEU314A, LYS210B, LYS229A, MET219B, MET231A, MET277A, PHE207B, PHE217B, PHE235A, PRO203B, PRO204B, SER218B, THR258A, THR258B, THR272A, THR272B, THR303B, THR310A, THR326A, TYR216B, TYR273A, TYR273B, TYR278A, VAL201B, VAL230B, VAL267B, VAL268B
• A-C: ALA144A, ALA254A, ALA280C, ARG199A, ARG220A, ARG224A, ARG274A, ARG274C, ARG327C, ARG57C, ASN285C, ASN313C, ASP200A, ASP202A, ASP221A, ASP223A, ASP256A, ASP317C, GLN228C, GLN325C, GLU205A, GLU275A, GLU275C, GLU281C, GLU282C, GLU306C, GLU307A, GLU328C, GLY197A, GLY226A, GLY269A, GLY270A, GLY276A, GLY329C, HIS206A, HIS284C, ILE222A, ILE227A, ILE227C, LEU198A, LEU209A, LEU225A, LEU259C, LEU271A, LEU314C, LYS210A, MET219A, MET231C, MET277C, PHE207A, PHE217A, PHE255A, PRO203A, PRO257A, SER218A, SER321C, SER60C, THR258A, THR258C, THR272A, THR272C, THR303A, THR310C, THR326C, TYR216A, TYR273A, TYR273C, TYR278C, VAL201A, VAL230A, VAL267A, VAL268A
• B-C: ALA144C, ALA146C, ALA254C, ALA280B, ARG199C, ARG220C, ARG224C, ARG274B, ARG274C, ARG327B, ASN285B, ASN313B, ASP200C, ASP202C, ASP221C, ASP223C, ASP256C, ASP317B, GLN228B, GLN325B, GLU205C, GLU232B, GLU275B, GLU275C, GLU281B, GLU282B, GLU328B, GLY197C, GLY226B, GLY226C, GLY269C, GLY270C, GLY276C, GLY329B, HIS206C, HIS284B, ILE222C, ILE227B, ILE227C, ILE279B, ILE283B, LEU198C, LEU209C, LEU225C, LEU259B, LEU271C, LEU314B, LYS210C, LYS229B, LYS229C, MET219C, MET231B, MET277B, PHE217C, PHE235B, PHE255C, PRO203C, SER218C, SER321B, THR258B, THR258C, THR272B, THR272C, THR310B, THR326B, TYR216C, TYR273B, TYR273C, TYR278B, VAL201C, VAL230C, VAL267C, VAL268C
• B-F: ALA27B, ARG50B, ARG57B, ARG90F, ASN83F, ASN84F, ASN88F, ASP67B, ASP79F, ASP80F, CYS63B, GLN177F, GLY180F, GLY329B, GLY53B, GLY62B, GLY69B, HIS24B, HIS64B, ILE86F, LEU178F, LEU54B, LEU58B, LEU61B, LEU65B, LEU81F, LEU85F, LEU94F, LYS56B, LYS66B, LYS78F, MET55B, PHE68B, PRO179F, PRO75F, PRO77F, PRO89F, SER59B, SER60B, SER91F, TYR82F, VAL26B, VAL28B, VAL76F
• C-E: ALA27E, ARG50E, ARG57E, ARG90C, ASN83C, ASN84C, ASN88C, ASP67E, ASP79C, ASP80C, CYS63E, GLN177C, GLY180C, GLY329E, GLY53E, GLY62E, GLY69E, HIS24E, HIS64E, ILE86C, LEU178C, LEU54E, LEU58E, LEU61E, LEU65E, LEU81C, LEU85C, LEU94C, LYS56E, LYS66E, LYS78C, MET55E, PHE68E, PRO179C, PRO75C, PRO77C, PRO89C, SER59E, SER60E, SER91C, TYR82C, VAL26E, VAL28E, VAL76C
• C-F: ASN149C, ASN149F, ASN211C, ASN211F, ASN83C, ASN83F, ASN84C, ASN84F, ASP173C, ASP173F, ASP202C, ASP202F, GLN172C, GLN172F, GLU205C, GLU205F, HIS206C, HIS206F, ILE208C, ILE208F, ILE86C, ILE86F, LEU152C, LEU152F, LEU171C, LEU171F, LEU85C, LEU85F, LYS174C, LYS174F, PHE207C, PHE207F, PRO151C, PRO151F, PRO176C, PRO176F, PRO203C, PRO203F, PRO204C, PRO204F, SER155C, SER155F, THR150C, THR150F, THR153C, THR153F, THR154C, THR154F, TYR212C, TYR212F, TYR82C, TYR82F, VAL175C, VAL175F
• D-E: ALA144E, ALA146E, ALA280D, ARG199E, ARG220E, ARG224E, ARG274D, ARG274E, ARG327D, ARG57D, ASN285D, ASN313D, ASP200E, ASP202E, ASP221E, ASP223E, ASP256E, ASP317D, GLN228D, GLN325D, GLU205E, GLU232D, GLU275D, GLU275E, GLU281D, GLU282D, GLU306D, GLU307E, GLU328D, GLY197E, GLY226D, GLY226E, GLY269E, GLY270E, GLY276D, GLY276E, GLY329D, HIS145E, HIS206E, HIS284D, ILE222E, ILE227D, ILE227E, ILE279D, ILE283D, LEU198E, LEU209E, LEU225E, LEU259D, LEU271E, LEU314D, LYS210E, LYS229D, MET219E, MET231D, MET277D, PHE207E, PHE217E, PHE235D, PRO203E, PRO204E, SER218E, THR258D, THR258E, THR272D, THR272E, THR303E, THR310D, THR326D, TYR216E, TYR273D, TYR273E, TYR278D, VAL201E, VAL230E, VAL267E, VAL268E
• D-F: ALA144D, ALA254D, ALA280F, ARG199D, ARG220D, ARG224D, ARG274D, ARG274F, ARG327F, ARG57F, ASN285F, ASN313F, ASP200D, ASP202D, ASP221D, ASP223D, ASP256D, ASP317F, GLN228F, GLN325F, GLU205D, GLU275D, GLU275F, GLU281F, GLU282F, GLU306F, GLU307D, GLU328F, GLY197D, GLY226D, GLY269D, GLY270D, GLY276D, GLY329F, HIS206D, HIS284F, ILE222D, ILE227D, ILE227F, LEU198D, LEU209D, LEU225D, LEU259F, LEU271D, LEU314F, LYS210D, MET219D, MET231F, MET277F, PHE207D, PHE217D, PHE255D, PRO203D, PRO257D, SER218D, SER321F, SER60F, THR258D, THR258F, THR272D, THR272F, THR303D, THR310F, THR326F, TYR216D, TYR273D, TYR273F, TYR278F, VAL201D, VAL230D, VAL267D, VAL268D
• E-F: ALA144F, ALA146F, ALA254F, ALA280E, ARG199F, ARG220F, ARG224F, ARG274E, ARG274F, ARG327E, ASN285E, ASN313E, ASP200F, ASP202F, ASP221F, ASP223F, ASP256F, ASP317E, GLN228E, GLN325E, GLU205F, GLU232E, GLU275E, GLU275F, GLU281E, GLU282E, GLU328E, GLY197F, GLY226E, GLY226F, GLY269F, GLY270F, GLY276F, GLY329E, HIS206F, HIS284E, ILE222F, ILE227E, ILE227F, ILE279E, ILE283E, LEU198F, LEU209F, LEU225F, LEU259E, LEU271F, LEU314E, LYS210F, LYS229E, LYS229F, MET219F, MET231E, MET277E, PHE217F, PHE235E, PHE255F, PRO203F, SER218F, SER321E, THR258E, THR258F, THR272E, THR272F, THR310E, THR326E, TYR216F, TYR273E, TYR273F, TYR278E, VAL201F, VAL230F, VAL267F, VAL268F