1PP9

bovine cytochrome bc1 complex with stigmatellin bound

• Total interactions analyzed: 190
• Total true interactions: 63
• Strongest Interaction:
  • Chains: G-H
  • Int. Res.: 23
  • Norm. En. per Res.: -8.026
• Hub Node: A(9)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-185.2876	-48.5708	-620.132	-853.9904	236	36	12	23864	7	59	55
A-C	-10.4233	-14.5429	-49.012	-73.9783	33	3	0	2027	3	11	14
A-D	-2.6963	4.325	-22.291	-20.6623	33	0	1	1141	0	9	12
A-E	-64.6553	-11.044	-260.544	-336.2433	107	14	4	10056	1	31	30
A-F	0.0	2.7196	-0.1841	2.5355	7	0	0	72	0	9	8
A-G	-149.502	-58.3369	-289.641	-497.4799	72	15	2	9610	2	20	11
A-I	-41.4765	20.3768	-223.673	-244.7727	88	19	5	8636	0	17	16
A-J	-5.305	-10.6533	-30.7196	-46.6779	23	1	0	1119	0	4	5
A-S	0.0	0.7643	-15.2242	-14.4599	18	5	0	858	0	9	5
B-I	-120.2375	-30.2425	-469.689	-620.169	167	34	26	19338	2	17	18
B-O	-45.1136	-220.7243	-193.594	-459.4319	88	3	0	5836	17	42	27
B-S	-6.2176	-34.3353	-118.563	-159.1159	51	2	0	4223	3	26	22
C-D	-42.7649	-86.685	-455.507	-584.9569	155	13	10	17581	12	37	38
C-E	-11.8568	0.657	-139.803	-151.0029	52	2	1	4918	2	3	1
C-F	-22.5905	23.8207	-317.846	-316.6158	112	12	7	13546	1	38	29
C-G	-12.942	-57.0064	-281.57	-351.5184	112	5	7	10578	5	17	12
C-J	0.0	0.0	-0.0065	-0.0065	2	0	0	4	0	0	0
C-P	0.0	27.3856	-159.276	-131.8904	89	0	8	7105	0	14	11
C-R	-16.078	5.4248	-314.866	-325.5192	117	5	6	13101	0	11	21
D-E	0.0	-16.9185	-144.174	-161.0925	91	7	4	6401	0	18	27
D-F	-10.2481	-20.3996	-86.7473	-117.395	38	5	1	3357	1	9	13
D-G	-69.3217	-14.6622	-206.636	-290.6199	62	8	4	7680	2	14	17
D-H	-44.3156	-3.4311	-328.962	-376.7086	110	13	5	13712	0	19	27
D-J	-66.1326	-87.8102	-278.57	-432.5128	83	9	6	9648	7	51	39
D-Q	-4.8271	1.08	-90.4997	-94.2468	38	0	0	3191	0	6	8
D-R	0.0	0.0	-0.1955	-0.1955	9	0	0	73	0	6	6
E-F	0.0	0.0	-0.1115	-0.1115	2	0	0	26	0	1	0
E-G	-30.5629	-66.5537	-161.455	-258.5717	45	5	3	5775	3	12	14
E-J	-18.5686	-15.1859	-194.405	-228.1595	60	6	15	7121	1	6	7
E-P	-34.5931	5.4312	-306.943	-336.1049	117	7	4	12989	0	11	21
E-Q	0.0	0.0	-0.1324	-0.1324	11	0	0	50	0	5	4
F-G	-19.3814	-61.1524	-83.817	-164.3508	48	1	2	3510	3	12	24
F-N	0.0	4.9561	-6.2364	-1.2803	15	0	0	327	0	8	6
F-O	-5.0895	-36.8246	-120.862	-162.7761	50	4	0	4278	3	27	24
G-H	-35.8533	-107.4914	-41.2542	-184.5989	23	6	0	1468	7	21	7
G-J	0.0	0.0	-0.01	-0.01	2	0	0	7	0	0	0
H-J	0.0	0.0	-0.0041	-0.0041	2	0	0	7	0	0	2
N-O	-176.3061	-52.6007	-612.887	-841.7939	232	36	12	23272	6	59	57
N-P	-6.9694	-13.1603	-51.7447	-71.8744	37	3	0	2040	3	13	14
N-Q	-2.1936	4.225	-22.8433	-20.8119	34	0	1	1148	0	11	12
N-R	-46.9758	-10.8414	-255.253	-313.0702	109	18	4	10092	1	31	30
N-S	0.0	2.6009	-0.1635	2.4374	8	0	0	69	0	9	8
N-T	-141.4258	-55.5113	-273.823	-470.7601	71	18	1	9459	2	20	12
N-V	-52.9187	19.4879	-216.042	-249.4728	89	20	5	8566	0	18	16
N-W	-3.5565	-11.3262	-30.6942	-45.5769	23	4	0	1167	0	4	5
O-V	-127.6719	-40.3159	-461.989	-629.9768	167	31	26	19133	2	16	18
P-Q	-43.2334	-95.7648	-462.047	-601.0453	158	19	10	17699	12	37	38
P-R	-11.5383	1.3813	-135.988	-146.145	50	3	1	4850	2	3	1
P-S	-20.7432	23.3257	-318.005	-315.4225	114	16	7	13614	2	39	31
P-T	-14.3089	-59.9691	-290.506	-364.784	115	4	7	10810	5	18	13
P-W	0.0	0.0	-0.007	-0.007	2	0	0	4	0	0	0
Q-R	-8.1195	-3.1642	-150.468	-161.7517	96	4	4	6654	0	21	30
Q-S	-10.1065	-19.0345	-87.0535	-116.1945	39	2	1	3419	1	9	14
Q-T	-75.7134	-7.3663	-195.18	-278.2597	57	12	5	7464	0	12	17
Q-U	-51.0205	-3.6653	-341.969	-396.6548	111	13	5	13884	0	17	27
Q-W	-72.3052	-93.9626	-300.224	-466.4918	86	18	6	10507	8	52	41
R-S	0.0	0.0	-0.2604	-0.2604	3	0	0	50	0	1	0
R-T	-35.6006	-70.0104	-166.387	-271.998	46	7	4	5910	3	12	14
R-W	-25.487	-17.1732	-190.315	-232.9751	58	5	15	7001	1	6	7
S-T	-15.0205	-64.7056	-83.8209	-163.547	48	0	2	3476	4	12	23
T-U	-8.7866	-72.3251	-23.3024	-104.4141	18	2	0	802	4	18	9
T-W	0.0	0.0	-0.0119	-0.0119	2	0	0	7	0	0	0
U-W	0.0	0.0	-0.006	-0.006	2	0	0	8	0	0	2

Interface residues

• A-B: ALA101A, ALA139B, ALA149B, ALA151B, ALA200A, ALA275A, ALA281B, ALA288A, ALA291B, ALA295A, ALA2A, ALA359B, ALA360B, ALA364A, ALA366B, ALA42B, ALA44B, ALA5A, ALA63A, ALA72B, ALA74A, ALA7A, ALA84A, ALA88A, ALA91B, ALA96A, ARG113B, ARG287B, ARG356A, ARG362A, ARG46B, ARG87B, ASN141A, ASN290B, ASN359A, ASN362B, ASN363A, ASN40B, ASN73A, ASN87A, ASP105A, ASP114B, ASP115B, ASP147B, ASP281A, ASP356B, ASP370A, CYS111B, CYS282A, CYS35A, GLN126A, GLN136A, GLN143B, GLN153B, GLN15A, GLN22B, GLN297B, GLN29A, GLN305A, GLN32A, GLN358B, GLN6A, GLN9A, GLU110B, GLU12B, GLU130A, GLU136B, GLU137A, GLU13A, GLU168A, GLU204A, GLU25B, GLU28A, GLU353A, GLU373B, GLU376B, GLU396A, GLU39B, GLU60A, GLU76A, GLU78A, GLU80A, GLU90B, GLY201A, GLY202A, GLY210B, GLY278A, GLY282B, GLY285A, GLY286A, GLY287A, GLY288B, GLY357A, GLY367B, GLY371A, GLY377B, GLY56A, GLY72A, GLY83A, GLY88B, GLY93B, GLY94B, HIS205A, HIS20B, HIS213B, HIS277B, HIS279A, HIS284B, HIS289A, HIS368A, HIS61A, HIS85A, ILE116A, ILE118B, ILE134A, ILE146B, ILE399A, ILE85B, ILE89B, ILE99A, LEU102A, LEU112B, LEU119B, LEU140B, LEU203A, LEU209B, LEU216B, LEU290A, LEU355A, LEU360A, LEU361A, LEU364B, LEU365A, LEU369A, LEU369B, LEU38B, LEU392A, LEU399B, LEU62A, LEU71B, LEU75A, LEU75B, LEU86A, LEU8A, LEU96B, LYS100A, LYS104A, LYS148B, LYS286B, LYS302A, LYS358A, LYS361B, LYS363B, LYS365B, LYS65A, LYS77A, LYS84B, LYS95B, MET370B, MET82A, PHE378B, PHE58A, PHE64A, PHE83B, PRO12A, PRO142B, PRO18B, PRO19B, PRO214B, PRO21B, PRO283B, PRO293A, PRO306B, PRO33A, PRO355B, PRO374A, PRO395B, PRO43B, SER103A, SER10A, SER212B, SER27A, SER289B, SER291A, SER292A, SER293B, SER296A, SER30A, SER31A, SER352A, SER367A, SER371B, SER374B, SER375B, SER396B, SER45B, SER73B, SER74B, SER81A, SER81B, SER82B, SER90A, SER97B, THR14A, THR1A, THR283A, THR292B, THR34A, THR36A, THR372A, THR373A, THR3A, THR76B, THR86B, TYR280A, TYR284A, TYR368B, TYR41B, TYR4A, TYR57A, TYR89A, TYR97A, TYR98A, VAL11A, VAL133A, VAL150B, VAL17B, VAL211B, VAL215B, VAL285B, VAL366A, VAL372B, VAL375A, VAL59A, VAL79A, VAL92B
• A-C: ARG244A, ARG436A, ARG438A, ASN15C, ASN16C, ASN435A, ASP20C, ASP214C, ASP216C, ASP332A, ASP433A, GLN430A, GLU429A, HIS221C, ILE19C, ILE218C, ILE226C, ILE437A, LEU21C, LEU431A, LYS217C, MET329A, PHE18C, PHE220C, PRO219C, PRO222C, PRO22C, PRO432A, SER439A, THR225C, TYR223C, TYR434A, VAL215C
• A-D: ALA236D, ARG233D, ARG238D, ARG244A, ARG436A, ARG438A, ASN435A, ASP142A, ASP433A, CYS242A, GLN240A, GLU245A, HIS225D, HIS243A, ILE241A, LEU230D, LEU235D, LYS223D, LYS226D, LYS231D, LYS234D, PHE442A, PRO239D, PRO240D, SER171A, SER228D, SER239A, SER439A, TRP227D, TYR152A, TYR237D, TYR434A, VAL229D
• A-E: ALA155A, ALA157A, ALA164A, ARG146A, ARG14E, ARG15E, ARG175A, ARG235A, ARG32E, ARG438A, ARG46A, ARG92A, ASN141A, ASN151A, ASN173A, ASN53A, ASP142A, ASP147A, ASP20E, ASP316A, ASP417A, ASP4E, ASP9E, CYS234A, CYS419A, GLN139A, GLN159A, GLN165A, GLN240A, GLN418A, GLU137A, GLU140A, GLU168A, GLU172A, GLU17E, GLU258A, GLU27E, GLU30E, GLU50A, GLY160A, GLY169A, GLY238A, GLY259A, GLY261A, GLY318A, HIS154A, HIS243A, HIS2E, ILE134A, ILE241A, ILE5E, LEU135A, LEU138A, LEU153A, LEU19E, LEU231A, LEU270A, LEU320A, LYS23E, LYS26E, LYS33E, LYS413A, LYS6E, MET441A, PHE10E, PHE150A, PHE158A, PHE236A, PHE415A, PHE425A, PHE442A, PRO162A, PRO170A, PRO233A, PRO260A, PRO8E, SER11E, SER144A, SER166A, SER171A, SER1E, SER21E, SER232A, SER239A, SER24E, SER25E, SER29E, SER36E, SER439A, THR143A, THR156A, THR161A, THR22E, THR237A, THR317A, THR3E, TYR152A, TYR37E, TYR414A, TYR416A, VAL148A, VAL149A, VAL167A, VAL174A, VAL18E, VAL257A, VAL7E
• A-F: ARG244A, ASP246A, GLU52F, GLY247A, LYS63F, TYR55F, VAL59F
• A-G: ALA155A, ALA421A, ALA423A, ARG11G, ARG235A, ARG244A, ARG2G, ARG436A, ARG438A, ARG9G, ASN435A, ASP246A, ASP327A, ASP332A, ASP333A, ASP417A, ASP433A, CYS242A, CYS419A, GLN159A, GLN23G, GLN240A, GLN3G, GLN418A, GLN430A, GLU22G, GLU245A, GLU429A, GLY238A, GLY247A, GLY424A, GLY426A, GLY5G, HIS12G, HIS243A, HIS328A, HIS6G, ILE14G, ILE241A, ILE331A, ILE428A, LEU18G, LEU248A, LEU431A, LEU7G, MET329A, MET441A, PHE21G, PHE236A, PHE425A, PHE442A, PHE4G, PRO20G, PRO249A, PRO420A, PRO427A, PRO432A, SER17G, SER19G, SER239A, SER330A, SER439A, THR156A, THR15G, THR237A, THR8G, TYR152A, TYR16G, TYR434A, VAL10G, VAL13G, VAL422A
• A-I: ALA275A, ALA32I, ALA33I, ALA364A, ALA36I, ALA74I, ARG146A, ARG356A, ARG362A, ARG52I, ASN141A, ASN359A, ASN363A, ASN71I, ASP132A, ASP142A, ASP281A, CYS282A, CYS304A, CYS326A, CYS51I, GLN126A, GLN136A, GLN139A, GLN305A, GLN308A, GLU130A, GLU137A, GLU140A, GLU39I, GLU53I, GLY278A, GLY285A, GLY286A, GLY287A, GLY357A, HIS252A, HIS279A, HIS289A, HIS323A, HIS368A, HIS61A, ILE134A, LEU135A, LEU138A, LEU250A, LEU290A, LEU360A, LEU361A, LEU365A, LEU369A, LEU50I, LEU55I, LEU70I, LYS129A, LYS65A, PHE307A, PHE324A, PRO249A, PRO35I, PRO41I, PRO73I, SER144A, SER291A, SER292A, SER306A, SER367A, SER38I, SER40I, SER48I, SER54I, SER67I, SER69I, SER75I, THR143A, THR283A, THR309A, THR37I, TYR280A, TYR284A, VAL133A, VAL325A, VAL34I, VAL366A, VAL42I, VAL49I, VAL68I, VAL72I
• A-J: ARG15J, ARG16J, ARG408A, ARG438A, ASP417A, CYS346A, CYS411A, GLN418A, GLU409A, LYS413A, MET343A, MET441A, PHE14J, PHE415A, PHE442A, SER18J, SER412A, THR17J, THR347A, TYR10J, TYR414A, TYR416A, VAL410A
• A-S: ALA108S, ALA288A, ALA404A, ARG104S, ARG356A, ARG49S, GLU100S, GLU351A, GLU353A, HIS289A, LEU355A, LYS109S, LYS110S, SER291A, SER352A, THR350A, TRP107S, VAL354A
• B-I: ALA106B, ALA149B, ALA151B, ALA157B, ALA255B, ALA256B, ALA281B, ALA300B, ALA311B, ALA314B, ALA32I, ALA33I, ALA36I, ALA59I, ALA60I, ALA66I, ALA72B, ALA74I, ALA91B, ARG102B, ARG145B, ARG287B, ARG46B, ARG52I, ARG56I, ARG62I, ARG70B, ARG77I, ARG87B, ASN104B, ASN154B, ASN162B, ASN290B, ASN313B, ASN71I, ASP147B, ASP308B, ASP380B, CYS111B, CYS51I, GLN143B, GLN153B, GLN156B, GLN276B, GLN297B, GLN305B, GLN329B, GLN58I, GLU103B, GLU110B, GLU161B, GLU376B, GLU39I, GLU53I, GLU90B, GLY280B, GLY282B, GLY288B, GLY320B, GLY323B, GLY57I, GLY61I, GLY88B, GLY93B, GLY94B, HIS158B, HIS164B, HIS254B, HIS277B, HIS284B, HIS304B, HIS67B, ILE146B, ILE160B, ILE264B, ILE327B, ILE85B, ILE89B, LEU119B, LEU140B, LEU144B, LEU152B, LEU163B, LEU172B, LEU176B, LEU252B, LEU279B, LEU295B, LEU321B, LEU50I, LEU55I, LEU64I, LEU68B, LEU69B, LEU70I, LEU71B, LEU96B, LYS148B, LYS286B, LYS301B, LYS363B, LYS95B, MET105B, PHE122B, PHE307B, PHE312B, PHE322B, PHE324B, PHE83B, PRO155B, PRO283B, PRO306B, PRO35I, PRO41I, PRO63I, PRO73I, SER100B, SER175B, SER251B, SER289B, SER293B, SER294B, SER310B, SER315B, SER328B, SER371B, SER38I, SER40I, SER48I, SER54I, SER67I, SER69I, SER73B, SER74B, SER75I, SER82B, SER97B, THR101B, THR108B, THR292B, THR326B, THR86B, THR99B, TYR107B, TYR177B, TYR296B, TYR316B, TYR325B, TYR78I, VAL109B, VAL126B, VAL150B, VAL159B, VAL253B, VAL285B, VAL299B, VAL303B, VAL309B, VAL34I, VAL42I, VAL49I, VAL65I, VAL68I, VAL72I, VAL76I, VAL92B, VAL98B
• B-O: ALA165B, ALA165O, ALA166B, ALA166O, ALA173B, ALA173O, ALA330B, ALA330O, ARG169B, ARG169O, ARG182B, ARG182O, ARG245B, ARG245O, ARG421B, ARG421O, ASN170B, ASN170O, ASN174B, ASN174O, ASN248B, ASN248O, ASN429B, ASN429O, ASN59B, ASN59O, ASN61B, ASN61O, ASN62B, ASN62O, ASP180B, ASP180O, ASP250B, ASP250O, ASP437B, ASP437O, GLN247B, GLN247O, GLU243B, GLU243O, GLU246B, GLU246O, GLU438B, GLU438O, GLY241B, GLY241O, GLY242B, GLY242O, GLY249B, GLY249O, GLY428B, GLY428O, GLY431B, GLY431O, HIS240B, HIS240O, HIS432B, HIS432O, ILE244B, ILE244O, ILE436B, ILE436O, LEU430B, LEU430O, LEU439B, LEU439O, LEU63B, LEU63O, LYS185B, LYS185O, LYS238B, LYS238O, PHE435B, PHE435O, PRO179B, PRO179O, PRO434B, PRO434O, SER60B, SER60O, THR433B, THR433O, TYR168B, TYR168O, TYR181B, TYR181O, TYR239B, TYR239O
• B-S: ALA108S, ALA138B, ALA139B, ALA46S, ALA80B, ALA91B, ARG104S, ARG133B, ARG134B, ARG48S, ARG49S, ARG87B, ARG99S, ASN53S, GLU100S, GLU103S, GLU105S, GLU106S, GLU131B, GLU136B, GLU45S, GLU52S, GLU90B, GLU96S, GLY79B, GLY88B, ILE118B, ILE47S, ILE85B, ILE89B, LEU50S, LEU54S, LYS102S, LYS110S, LYS78B, LYS84B, PHE122B, PHE83B, PRO51S, PRO92S, SER81B, SER82B, THR76B, THR77B, THR86B, TRP107S, TRP135B, TYR55S, TYR93S, VAL92B, VAL97S
• C-D: ALA119D, ALA193D, ALA194D, ALA221D, ALA232C, ALA238C, ALA23C, ALA246C, ALA47D, ARG102D, ARG118D, ARG120D, ARG191D, ARG201D, ARG203D, ARG224D, ARG233D, ARG49D, ARG71C, ARG80C, ASN255C, ASN260C, ASN263C, ASN26C, ASN32C, ASN85C, ASP112D, ASP199D, ASP216C, ASP228C, ASP248C, ASP252C, ASP254C, ASP2D, ASP44D, ASP72C, CYS70C, GLN137C, GLU195D, GLU197D, GLU344C, GLU4D, GLY122D, GLY123D, GLY155D, GLY16D, GLY205D, GLY213D, GLY231C, GLY251C, GLY76C, HIS121D, HIS198D, HIS200D, HIS221C, HIS225D, HIS267C, HIS50D, HIS68C, ILE116D, ILE218C, ILE226C, ILE229C, ILE236C, ILE268C, ILE27C, ILE78C, LEU109D, LEU113D, LEU17D, LEU18D, LEU190D, LEU206D, LEU209D, LEU210D, LEU214D, LEU215D, LEU216D, LEU218D, LEU230C, LEU230D, LEU233C, LEU234C, LEU235C, LEU235D, LEU237C, LEU239C, LEU241C, LEU242C, LEU244C, LEU249C, LEU262C, LYS202D, LYS207D, LYS217C, LYS223D, LYS226D, LYS227C, LYS231D, LYS269C, MET204D, MET208D, MET211D, MET212D, MET222D, MET240C, MET43D, MET82C, PHE220C, PHE245C, PHE63C, PRO111D, PRO154D, PRO196D, PRO217D, PRO219C, PRO222C, PRO247C, PRO24C, PRO253C, PRO258C, PRO266C, PRO342C, SER114D, SER19D, SER228D, SER25C, SER28C, SER29C, SER64C, SER65C, THR225C, THR257C, THR60C, THR61C, THR67C, TRP192D, TRP227D, TRP77C, TYR115D, TYR220D, TYR223C, TYR224C, TYR256C, TYR45D, TYR75C, TYR81C, TYR90D, VAL117D, VAL215C, VAL219D, VAL229D, VAL243C, VAL46D, VAL66C
• C-E: ALA50E, ALA64E, ALA66E, ARG71C, ARG80C, ASN53E, ASN74C, ASP67E, ASP72C, GLN57E, GLY48C, GLY76C, HIS54C, HIS68C, HIS83C, ILE226C, ILE229C, ILE236C, ILE45C, ILE69C, ILE78C, ILE79C, LEU233C, LEU244C, LEU43C, LEU46C, LEU49C, LEU51C, LEU69E, MET240C, MET53C, MET62E, MET82C, PHE50C, PHE58E, SER56E, SER60E, SER61E, SER63E, SER65E, THR40E, THR43E, THR47C, TRP77C, TYR75C, VAL243C, VAL47E, VAL54E, VAL55E, VAL59E, VAL68E, VAL73C
• C-F: ALA23F, ALA24F, ALA369C, ALA65F, ARG17F, ARG313C, ARG318C, ARG33F, ARG58F, ARG61F, ARG64F, ARG71F, ASN206C, ASN207C, ASN22F, ASN26C, ASN27F, ASN374C, ASN40F, ASP214C, ASP216C, ASP34F, ASP35F, ASP56F, ASP67F, ASP86F, CYS323C, GLN312C, GLN322C, GLN72F, GLU14F, GLU373C, GLU39F, GLU84F, GLU91F, GLY105C, GLY15F, GLY210C, GLY25F, GLY370C, HIS308C, HIS38F, ILE16F, ILE211C, ILE218C, ILE27C, ILE372C, ILE37F, ILE47F, ILE62F, ILE74F, ILE98F, LEU110C, LEU13F, LEU29F, LEU31F, LEU320C, LEU376C, LEU377C, LEU66F, LEU68F, LEU90F, LEU94F, LYS18F, LYS217C, LYS227C, LYS28F, LYS311C, LYS375C, LYS378C, LYS44F, LYS63F, LYS87F, MET315C, MET316C, MET32F, MET70F, PHE109C, PHE26F, PHE317C, PHE60F, PRO208C, PRO24C, PRO319C, SER106C, SER212C, SER213C, SER25C, SER28C, SER29C, SER310C, SER314C, SER321C, SER69F, SER88F, THR108C, THR203C, THR209C, THR36F, TRP19F, TRP30C, TRP31C, TRP379C, TYR104C, TYR20F, TYR21F, TYR224C, TYR55F, TYR83F, VAL215C, VAL43F, VAL59F
• C-G: ALA23C, ALA327C, ALA330C, ALA354C, ALA43G, ALA49G, ALA54G, ARG11G, ARG2G, ARG318C, ARG40G, ARG47G, ARG9G, ASN16C, ASP20C, ASP214C, ASP216C, ASP331C, CYS323C, CYS44G, GLN322C, GLN341C, GLN3G, GLN64G, GLU202C, GLU344C, GLU65G, GLU67G, GLY1G, GLY204C, GLY351C, GLY5G, GLY62G, HIS201C, HIS221C, HIS267C, HIS345C, HIS6G, ILE19C, ILE218C, ILE338C, ILE348C, ILE350C, LEU200C, LEU21C, LEU320C, LEU324C, LEU328C, LEU332C, LEU333C, LEU335C, LEU353C, LEU357C, LEU361C, LEU46G, LEU57G, LEU7G, LYS217C, LYS68G, LYS70G, MET315C, MET316C, PHE109C, PHE220C, PHE317C, PHE325C, PHE4G, PHE52G, PHE55G, PHE66G, PRO20G, PRO219C, PRO222C, PRO22C, PRO24C, PRO319C, PRO342C, PRO346C, PRO50G, PRO51G, SER17G, SER205C, SER212C, SER213C, SER28C, SER29C, SER321C, SER69G, THR15G, THR203C, THR334C, THR336C, THR349C, THR60G, THR63G, THR8G, TRP326C, TRP337C, TRP61G, TYR103C, TYR223C, TYR347C, TYR56G, TYR59G, VAL10G, VAL13G, VAL215C, VAL329C, VAL343C, VAL48G, VAL53G, VAL58G
• C-J: PHE245C, TYR43J
• C-P: ALA173C, ALA173P, ALA180C, ALA180P, ALA191C, ALA191P, ALA52C, ALA52P, ARG177C, ARG177P, ASN74C, ASN74P, ASP58C, ASP58P, GLY166C, GLY166P, GLY48C, GLY48P, HIS182C, HIS182P, HIS54C, HIS54P, HIS68C, HIS68P, ILE13P, ILE184C, ILE184P, ILE188C, ILE188P, ILE45C, ILE45P, ILE69C, ILE69P, LEU10P, LEU175C, LEU175P, LEU185C, LEU185P, LEU198C, LEU49C, LEU49P, LEU51C, LEU51P, LYS172C, LYS172P, MET190C, MET190P, MET194C, MET194P, MET53C, MET53P, PHE178C, PHE178P, PHE179C, PHE179P, PHE181C, PHE181P, PHE183C, PHE183P, PHE187C, PHE187P, PHE199C, PHE50C, PHE50P, PRO186C, PRO186P, SER57C, SER57P, SER65C, SER65P, THR174C, THR174P, THR176C, THR176P, THR56C, THR56P, THR59C, THR59P, THR60C, THR60P, THR61C, THR61P, TRP163C, TRP163P, TYR55C, TYR55P, VAL195C, VAL73C, VAL73P
• C-R: ALA143C, ALA148R, ALA150R, ALA152C, ALA173C, ALA176R, ALA279C, ALA64R, ALA70R, ALA88R, ARG118R, ARG177C, ARG282C, ARG92R, ASN148C, ASN159C, ASN260C, ASN263C, ASN286C, ASP152R, ASP171C, ASP67R, CYS139R, CYS144R, CYS158R, CYS160R, GLU162C, GLU344C, GLY137R, GLY142C, GLY143R, GLY162R, GLY166C, GLY167C, GLY174R, GLY289C, GLY290C, GLY93R, HIS141R, HIS161R, HIS164R, HIS267C, ILE146C, ILE147R, ILE164C, ILE268C, ILE284C, ILE348C, LEU142R, LEU149C, LEU150C, LEU160C, LEU178R, LEU262C, LEU281C, LEU288C, LEU294C, LEU69R, LEU96R, LYS172C, LYS173R, LYS269C, LYS287C, LYS90R, LYS94R, MET138C, MET62R, MET71R, MET87R, PHE140C, PHE168C, PHE178C, PHE181C, PHE58R, PHE89R, PHE97R, PRO146R, PRO159R, PRO175R, PRO177R, PRO261C, PRO265C, PRO266C, PRO270C, PRO285C, PRO342C, PRO95R, SER151C, SER163R, SER169C, SER283C, SER60R, SER61R, SER63R, SER65R, THR140R, THR144C, THR147C, THR158C, THR174C, THR264C, TRP141C, TRP163C, TRP165C, TRP91R, TYR157R, TYR278C, VAL138R, VAL145C, VAL145R, VAL161C, VAL170C, VAL291C, VAL343C, VAL55R, VAL59R, VAL68R
• D-E: ALA221D, ALA236D, ALA41E, ALA47D, ALA48E, ALA50E, ALA51E, ALA66E, ALA70E, ARG14E, ARG15E, ARG224D, ARG233D, ARG238D, ARG32E, ARG49D, ASN53E, ASP12E, ASP4E, ASP67E, ASP80E, ASP89D, ASP9E, GLN57E, GLU76D, GLY46E, HIS200D, HIS225D, HIS2E, HIS50D, ILE5E, ILE74E, LEU210D, LEU214D, LEU215D, LEU216D, LEU218D, LEU230D, LEU235D, LEU38E, LEU69E, LEU87D, LYS207D, LYS223D, LYS226D, LYS231D, LYS234D, LYS33E, LYS62D, LYS6E, LYS73E, LYS77E, LYS86D, MET204D, MET208D, MET211D, MET212D, MET222D, MET71E, MET87E, PHE10E, PHE35E, PHE89E, PRO217D, PRO8E, SER11E, SER1E, SER228D, SER232D, SER36E, SER65E, SER72E, SER88D, THR3E, THR40E, THR42E, THR43E, THR44E, TYR13E, TYR220D, TYR37E, TYR49E, TYR90D, VAL219D, VAL229D, VAL39E, VAL45E, VAL47E, VAL54E, VAL68E, VAL7E
• D-F: ALA236D, ALA65F, ARG233D, ARG238D, ARG58F, ARG61F, ARG64F, ARG71F, ASN53F, ASP56F, ASP57F, ASP67F, GLN72F, GLN73F, GLU52F, ILE62F, LEU230D, LEU235D, LEU54F, LEU66F, LEU68F, LYS223D, LYS231D, LYS234D, LYS241D, LYS63F, MET70F, PHE60F, PRO239D, PRO240D, SER228D, SER232D, SER69F, TRP227D, TYR237D, TYR55F, VAL229D, VAL59F
• D-G: ALA221D, ALA236D, ALA25G, ARG11G, ARG224D, ARG233D, ARG238D, ARG24G, ARG40G, ARG71G, ASP2D, GLN23G, GLU22G, GLU4D, GLU67G, GLY140D, GLY33G, HIS12G, HIS225D, HIS28G, HIS6D, ILE14G, LEU18G, LEU216D, LEU218D, LEU230D, LEU235D, LEU3D, LYS223D, LYS226D, LYS231D, LYS234D, LYS241D, LYS70G, LYS72G, MET222D, PHE21G, PHE26G, PHE30G, PHE66G, PRO138D, PRO20G, PRO217D, PRO239D, PRO240D, PRO27G, SER17G, SER19G, SER1D, SER228D, SER232D, THR139D, THR15G, TRP227D, TYR16G, TYR220D, TYR237D, TYR29G, VAL10G, VAL13G, VAL219D, VAL229D
• D-H: ALA177D, ALA183D, ALA64H, ALA70H, ARG15D, ARG21H, ARG28D, ARG43H, ARG47H, ARG65H, ASN150D, ASN166D, ASN75H, ASP125D, ASP15H, ASP173D, ASP185D, ASP22D, ASP2D, ASP41H, ASP53H, ASP60H, ASP66H, CYS135D, CYS187D, CYS40H, CYS54H, CYS68H, GLN156D, GLN181D, GLU124D, GLU136D, GLU167D, GLU38H, GLU42H, GLU4D, GLU51H, GLU52H, GLU56H, GLU57H, GLY133D, GLY140D, GLY155D, GLY174D, HIS14D, HIS63H, HIS67H, HIS6D, HIS71H, LEU131D, LEU13H, LEU143D, LEU17H, LEU37H, LEU3D, LEU58H, LEU59H, LEU5D, LEU62H, LEU73H, LEU77H, LYS184D, LYS72H, LYS78H, MET179D, PHE128D, PHE149D, PHE153D, PHE171D, PHE61H, PHE74H, PRO11D, PRO137D, PRO138D, PRO151D, PRO16H, PRO176D, PRO7D, PRO8D, SER129D, SER13D, SER142D, SER180D, SER1D, SER25D, SER45H, SER46H, SER76H, SER9D, THR132D, THR139D, THR175D, THR178D, THR188D, THR18H, THR24D, THR50H, THR55H, TRP12D, TYR10D, TYR134D, TYR152D, TYR165D, VAL141D, VAL14H, VAL168D, VAL182D, VAL20H, VAL44H, VAL69H
• D-J: ALA39J, ALA41J, ARG15D, ARG201D, ARG203D, ARG27D, ARG28D, ASN47J, ASN61J, ASP172D, ASP173D, ASP199D, ASP22D, ASP36J, ASP40J, ASP59D, CYS55D, GLN31D, GLN37J, GLU197D, GLU32J, GLU44J, GLU48J, GLU58D, GLU60D, GLU60J, GLY16D, GLY205D, GLY213D, GLY38J, GLY49J, GLY53D, HIS14D, HIS198D, HIS200D, HIS23D, HIS45J, HIS54J, HIS57J, ILE26D, ILE42J, ILE46J, ILE55J, LEU17D, LEU18D, LEU206D, LEU209D, LEU210D, LEU214D, LEU215D, LEU21D, LEU51D, LEU51J, LYS184D, LYS202D, LYS207D, LYS50J, LYS53J, LYS56J, LYS58J, LYS62J, MET204D, MET208D, MET211D, MET212D, MET222D, PHE20J, PHE31J, PHE35J, SER13D, SER19D, SER20D, SER25D, THR188D, THR24D, THR57D, TRP12D, TRP52J, TYR43J, TYR56D, TYR59J, VAL52D, VAL54D
• D-Q: ALA100D, ALA100Q, ALA101D, ALA101Q, ALA103D, ALA103Q, ALA104D, ALA104Q, ARG102D, ARG102Q, ASN75D, ASN75Q, ASN97D, ASN97Q, ASP77D, ASP77Q, GLU76D, GLU76Q, GLU79D, GLU79Q, GLU99D, GLU99Q, GLY107D, GLY107Q, GLY73D, GLY73Q, GLY78D, GLY78Q, MET80D, MET80Q, PRO74D, PRO74Q, PRO96D, PRO96Q, PRO98D, PRO98Q, TYR95D, TYR95Q
• D-R: ARG102D, ARG144D, ASN106D, ASN149R, GLU83R, GLY107D, GLY84R, LYS85R, MET87R
• E-F: ARG71F, TYR13E
• E-G: ALA25G, ALA31E, ARG14E, ARG15E, ARG24G, ARG32E, ASP12E, ASP4E, ASP9E, GLN23G, GLU17E, GLU22G, GLY34E, HIS28G, HIS2E, ILE14G, ILE5E, LEU18G, LEU19E, LEU38E, LYS32G, LYS33E, LYS6E, PHE10E, PHE21G, PHE26G, PHE35E, PRO16E, PRO20G, PRO27G, PRO8E, SER11E, SER17G, SER19G, SER25E, SER28E, SER29E, SER36E, THR15G, TYR13E, TYR16G, TYR37E, VAL18E, VAL39E, VAL7E
• E-J: ALA21J, ALA28J, ALA31E, ALA39J, ALA41E, ALA48E, ALA50E, ALA7J, ARG15E, ARG15J, ARG32E, ARG33J, ARG8J, ASN53E, ASP36J, ASP40J, GLN37J, GLU17E, GLU27E, GLU30E, GLU32J, GLY27J, GLY34E, GLY46E, ILE24J, LEU12J, LEU13J, LEU22J, LEU29J, LEU38E, LEU5J, LEU9J, LYS33E, LYS52E, PHE14J, PHE20J, PHE30J, PHE31J, PHE35E, PHE35J, PRO3J, SER11J, SER28E, SER29E, SER36E, THR23J, THR40E, THR42E, THR43E, THR44E, THR4J, THR6J, TYR10J, TYR37E, TYR49E, VAL25J, VAL26J, VAL39E, VAL45E, VAL47E
• E-P: ALA143P, ALA148E, ALA150E, ALA152P, ALA173P, ALA176E, ALA279P, ALA64E, ALA70E, ALA88E, ARG118E, ARG177P, ARG282P, ARG92E, ASN148P, ASN159P, ASN260P, ASN263P, ASN286P, ASP152E, ASP171P, ASP67E, CYS139E, CYS144E, CYS158E, CYS160E, GLU162P, GLU344P, GLY137E, GLY142P, GLY143E, GLY162E, GLY166P, GLY167P, GLY174E, GLY289P, GLY290P, GLY93E, HIS141E, HIS161E, HIS164E, HIS267P, HIS345P, ILE146P, ILE147E, ILE164P, ILE268P, ILE284P, ILE348P, LEU142E, LEU149P, LEU150P, LEU160P, LEU178E, LEU262P, LEU281P, LEU288P, LEU294P, LEU69E, LEU96E, LYS172P, LYS173E, LYS269P, LYS287P, LYS90E, LYS94E, MET138P, MET62E, MET71E, MET87E, PHE140P, PHE168P, PHE178P, PHE181P, PHE58E, PHE89E, PHE97E, PRO146E, PRO159E, PRO175E, PRO177E, PRO261P, PRO265P, PRO266P, PRO270P, PRO285P, PRO342P, PRO95E, SER151P, SER163E, SER169P, SER283P, SER60E, SER61E, SER63E, SER65E, THR140E, THR144P, THR147P, THR158P, THR264P, TRP141P, TRP163P, TRP165P, TRP91E, TYR157E, TYR278P, VAL138E, VAL145E, VAL145P, VAL161P, VAL170P, VAL291P, VAL343P, VAL55E, VAL59E, VAL68E
• E-Q: ALA150E, ARG102Q, ARG144Q, ASN149E, ASP2Q, GLU83E, GLY151E, GLY84E, LYS85E, MET87E, PRO82E
• F-G: ALA23F, ALA24F, ALA43G, ARG11G, ARG2G, ARG39G, ARG40G, ARG47G, ARG48F, ARG64F, ARG71F, ARG9G, ASN22F, ASN36G, ASN53F, ASP56F, ASP57F, ASP67F, GLN72F, GLN73F, GLU52F, GLY25F, GLY33G, HIS12G, ILE14G, ILE47F, ILE74F, LEU29F, LEU46G, LEU68F, LEU75F, LYS28F, LYS32G, LYS44F, LYS63F, PHE60F, PRO35G, SER69F, THR15G, THR8G, TRP19F, TRP80F, TYR20F, TYR55F, VAL10G, VAL13G, VAL37G, VAL59F
• F-N: ALA108F, ALA288N, ARG104F, ARG356N, ARG49F, GLU100F, GLU351N, GLU353N, HIS289N, LYS109F, LYS110F, SER291N, SER352N, THR350N, TRP107F
• F-O: ALA108F, ALA138O, ALA139O, ALA80O, ALA91O, ARG104F, ARG133O, ARG134O, ARG48F, ARG49F, ARG87O, ARG99F, ASN53F, GLU100F, GLU103F, GLU105F, GLU106F, GLU131O, GLU136O, GLU45F, GLU52F, GLU90O, GLU96F, GLY79O, GLY88O, ILE118O, ILE47F, ILE85O, ILE89O, LEU50F, LEU54F, LYS102F, LYS110F, LYS78O, LYS84O, PHE122O, PHE83O, PRO51F, PRO92F, SER81O, SER82O, THR76O, THR77O, THR86O, TRP107F, TRP135O, TYR55F, TYR93F, VAL92O, VAL97F
• G-H: ARG36H, ARG43H, ARG47H, ARG71G, ASN73G, ASP53H, ASP60H, CYS40H, CYS54H, GLU51H, GLU52H, GLU56H, GLU57H, GLU67G, HIS63H, LEU37H, LEU58H, LEU59H, LYS68G, LYS70G, LYS72G, THR55H, VAL44H
• G-J: PHE21G, TYR10J
• H-J: LYS58J, LYS78H
• N-O: ALA101N, ALA149O, ALA151O, ALA200N, ALA275N, ALA281O, ALA288N, ALA291O, ALA295N, ALA2N, ALA359O, ALA360O, ALA364N, ALA366O, ALA42O, ALA44O, ALA5N, ALA63N, ALA72O, ALA74N, ALA7N, ALA84N, ALA88N, ALA91O, ALA96N, ARG113O, ARG206N, ARG287O, ARG356N, ARG362N, ARG46O, ARG87O, ASN141N, ASN290O, ASN359N, ASN362O, ASN363N, ASN40O, ASN73N, ASN87N, ASP105N, ASP114O, ASP115O, ASP147O, ASP281N, ASP356O, ASP370N, CYS111O, CYS282N, CYS35N, GLN126N, GLN136N, GLN143O, GLN153O, GLN15N, GLN297O, GLN29N, GLN305N, GLN32N, GLN358O, GLN6N, GLN9N, GLU110O, GLU12O, GLU130N, GLU136O, GLU137N, GLU13N, GLU168N, GLU204N, GLU28N, GLU353N, GLU373O, GLU376O, GLU396N, GLU39O, GLU60N, GLU76N, GLU78N, GLU80N, GLU90O, GLY201N, GLY202N, GLY210O, GLY278N, GLY282O, GLY285N, GLY286N, GLY287N, GLY288O, GLY357N, GLY367O, GLY371N, GLY377O, GLY56N, GLY72N, GLY83N, GLY88O, GLY93O, GLY94O, HIS205N, HIS20O, HIS213O, HIS277O, HIS279N, HIS284O, HIS289N, HIS61N, HIS85N, ILE116N, ILE118O, ILE134N, ILE146O, ILE379N, ILE399N, ILE85O, ILE89O, ILE99N, LEU102N, LEU112O, LEU119O, LEU140O, LEU203N, LEU209O, LEU216O, LEU290N, LEU355N, LEU360N, LEU361N, LEU364O, LEU365N, LEU369N, LEU369O, LEU392N, LEU399O, LEU62N, LEU71O, LEU75N, LEU75O, LEU86N, LEU8N, LEU96O, LYS100N, LYS104N, LYS148O, LYS286O, LYS302N, LYS358N, LYS361O, LYS363O, LYS365O, LYS65N, LYS77N, LYS84O, LYS95O, MET370O, MET82N, PHE378O, PHE58N, PHE64N, PHE83O, PRO12N, PRO142O, PRO18O, PRO19O, PRO214O, PRO21O, PRO283O, PRO293N, PRO306O, PRO33N, PRO355O, PRO374N, PRO395O, PRO43O, SER103N, SER10N, SER212O, SER27N, SER289O, SER291N, SER292N, SER293O, SER296N, SER30N, SER31N, SER352N, SER367N, SER371O, SER374O, SER375O, SER396O, SER45O, SER73O, SER74O, SER81N, SER81O, SER82O, SER90N, THR14N, THR1N, THR283N, THR292O, THR34N, THR36N, THR372N, THR373N, THR3N, THR76O, THR86O, TYR280N, TYR284N, TYR368O, TYR41O, TYR4N, TYR57N, TYR89N, TYR97N, TYR98N, VAL11N, VAL133N, VAL150O, VAL17O, VAL211O, VAL215O, VAL285O, VAL366N, VAL372O, VAL375N, VAL59N, VAL79N, VAL92O
• N-P: ARG244N, ARG436N, ARG438N, ASN15P, ASN16P, ASN435N, ASP20P, ASP214P, ASP216P, ASP332N, ASP333N, ASP433N, GLN430N, GLU429N, HIS221P, ILE19P, ILE218P, ILE226P, ILE437N, LEU21P, LEU431N, LYS12P, LYS217P, MET11P, MET329N, PHE18P, PHE220P, PHE336N, PRO219P, PRO222P, PRO22P, PRO432N, SER439N, THR225P, TYR223P, TYR434N, VAL215P
• N-Q: ALA236Q, ARG233Q, ARG238Q, ARG244N, ARG436N, ARG438N, ASN435N, ASP142N, ASP433N, CYS242N, CYS419N, GLN240N, GLU245N, HIS225Q, HIS243N, ILE241N, LEU230Q, LEU235Q, LYS223Q, LYS226Q, LYS231Q, LYS234Q, PHE442N, PRO239Q, PRO240Q, SER171N, SER228Q, SER239N, SER439N, TRP227Q, TYR152N, TYR237Q, TYR434N, VAL229Q
• N-R: ALA155N, ALA157N, ALA164N, ARG146N, ARG14R, ARG15R, ARG175N, ARG235N, ARG32R, ARG438N, ARG46N, ARG92N, ASN141N, ASN151N, ASN173N, ASN53N, ASP142N, ASP147N, ASP20R, ASP316N, ASP417N, ASP4R, ASP9R, CYS234N, CYS419N, GLN139N, GLN159N, GLN165N, GLN240N, GLN418N, GLU137N, GLU140N, GLU168N, GLU172N, GLU17R, GLU258N, GLU27R, GLU30R, GLU50N, GLY160N, GLY169N, GLY238N, GLY259N, GLY261N, GLY318N, HIS154N, HIS243N, HIS264N, HIS2R, ILE134N, ILE241N, ILE5R, LEU135N, LEU138N, LEU153N, LEU19R, LEU231N, LEU270N, LEU320N, LYS23R, LYS26R, LYS33R, LYS413N, LYS6R, MET441N, PHE10R, PHE150N, PHE158N, PHE236N, PHE415N, PHE425N, PHE442N, PRO162N, PRO170N, PRO233N, PRO260N, PRO8R, SER11R, SER144N, SER166N, SER171N, SER1R, SER21R, SER232N, SER239N, SER24R, SER25R, SER28R, SER29R, SER36R, SER439N, THR143N, THR156N, THR161N, THR22R, THR237N, THR317N, THR3R, TYR152N, TYR37R, TYR414N, TYR416N, VAL148N, VAL149N, VAL167N, VAL174N, VAL18R, VAL257N, VAL7R
• N-S: ARG244N, ASP246N, ASP56S, GLU52S, GLY247N, LYS63S, TYR55S, VAL59S
• N-T: ALA155N, ALA421N, ARG11T, ARG235N, ARG244N, ARG2T, ARG436N, ARG438N, ARG9T, ASN435N, ASP246N, ASP327N, ASP332N, ASP333N, ASP417N, ASP433N, CYS242N, CYS419N, GLN159N, GLN23T, GLN240N, GLN3T, GLN418N, GLN430N, GLU22T, GLU245N, GLU429N, GLY238N, GLY247N, GLY424N, GLY426N, GLY5T, HIS12T, HIS243N, HIS328N, HIS6T, ILE14T, ILE241N, ILE331N, ILE428N, LEU18T, LEU248N, LEU431N, LEU7T, MET329N, MET441N, PHE21T, PHE236N, PHE425N, PHE442N, PHE4T, PRO20T, PRO249N, PRO420N, PRO427N, PRO432N, SER17T, SER19T, SER239N, SER330N, SER439N, THR156N, THR15T, THR237N, THR8T, TYR152N, TYR16T, TYR434N, VAL10T, VAL13T, VAL422N
• N-V: ALA275N, ALA32V, ALA33V, ALA364N, ALA36V, ALA74V, ARG146N, ARG356N, ARG362N, ARG52V, ASN141N, ASN359N, ASN363N, ASN71V, ASP132N, ASP142N, ASP281N, CYS282N, CYS304N, CYS326N, CYS51V, GLN126N, GLN136N, GLN139N, GLN305N, GLN308N, GLU130N, GLU137N, GLU140N, GLU39V, GLU53V, GLU76N, GLY278N, GLY285N, GLY286N, GLY287N, GLY357N, HIS252N, HIS279N, HIS289N, HIS323N, HIS368N, HIS61N, ILE134N, LEU135N, LEU138N, LEU250N, LEU290N, LEU360N, LEU361N, LEU365N, LEU369N, LEU50V, LEU55V, LEU70V, LYS129N, LYS65N, PHE307N, PHE324N, PRO249N, PRO35V, PRO41V, PRO73V, SER144N, SER291N, SER292N, SER306N, SER367N, SER38V, SER40V, SER48V, SER54V, SER67V, SER69V, SER75V, THR143N, THR283N, THR309N, THR37V, TYR280N, TYR284N, VAL133N, VAL325N, VAL34V, VAL366N, VAL42V, VAL49V, VAL68V, VAL72V
• N-W: ARG15W, ARG16W, ARG408N, ARG438N, ASP417N, CYS346N, CYS411N, GLN418N, GLU409N, LYS413N, MET343N, MET441N, PHE14W, PHE415N, PHE442N, SER18W, SER412N, THR17W, THR347N, TYR10W, TYR414N, TYR416N, VAL410N
• O-V: ALA106O, ALA149O, ALA151O, ALA157O, ALA255O, ALA256O, ALA281O, ALA291O, ALA300O, ALA311O, ALA314O, ALA32V, ALA33V, ALA36V, ALA59V, ALA60V, ALA66V, ALA72O, ALA74V, ALA91O, ARG102O, ARG145O, ARG287O, ARG46O, ARG52V, ARG56V, ARG62V, ARG70O, ARG77V, ARG87O, ASN104O, ASN154O, ASN162O, ASN290O, ASN313O, ASN71V, ASP147O, ASP308O, ASP380O, CYS111O, CYS51V, GLN143O, GLN153O, GLN156O, GLN276O, GLN297O, GLN305O, GLN329O, GLN58V, GLU103O, GLU110O, GLU161O, GLU376O, GLU39V, GLU53V, GLU90O, GLY280O, GLY282O, GLY288O, GLY320O, GLY323O, GLY57V, GLY61V, GLY88O, GLY93O, GLY94O, HIS158O, HIS164O, HIS254O, HIS277O, HIS284O, HIS304O, HIS67O, ILE146O, ILE160O, ILE264O, ILE327O, ILE85O, ILE89O, LEU119O, LEU140O, LEU144O, LEU152O, LEU163O, LEU172O, LEU176O, LEU252O, LEU279O, LEU295O, LEU321O, LEU50V, LEU55V, LEU64V, LEU68O, LEU69O, LEU70V, LEU71O, LEU96O, LYS148O, LYS286O, LYS363O, LYS95O, MET105O, PHE122O, PHE307O, PHE312O, PHE322O, PHE324O, PHE83O, PRO155O, PRO283O, PRO306O, PRO35V, PRO41V, PRO63V, PRO73V, SER100O, SER175O, SER251O, SER289O, SER293O, SER294O, SER310O, SER315O, SER328O, SER371O, SER38V, SER40V, SER48V, SER54V, SER67V, SER69V, SER73O, SER74O, SER75V, SER82O, SER97O, THR101O, THR108O, THR292O, THR326O, THR86O, THR99O, TYR107O, TYR177O, TYR296O, TYR316O, TYR325O, TYR78V, VAL109O, VAL126O, VAL150O, VAL159O, VAL253O, VAL285O, VAL299O, VAL303O, VAL309O, VAL34V, VAL42V, VAL49V, VAL65V, VAL68V, VAL72V, VAL76V, VAL92O, VAL98O
• P-Q: ALA119Q, ALA193Q, ALA194Q, ALA221Q, ALA232P, ALA238P, ALA23P, ALA246P, ALA47Q, ALA62P, ARG102Q, ARG118Q, ARG120Q, ARG191Q, ARG201Q, ARG203Q, ARG224Q, ARG233Q, ARG49Q, ARG71P, ARG80P, ASN255P, ASN260P, ASN263P, ASN26P, ASN32P, ASN85P, ASP112Q, ASP199Q, ASP216P, ASP228P, ASP248P, ASP252P, ASP254P, ASP2Q, ASP44Q, ASP72P, CYS70P, GLN137P, GLU195Q, GLU197Q, GLU344P, GLU4Q, GLY122Q, GLY123Q, GLY16Q, GLY205Q, GLY213Q, GLY231P, GLY251P, GLY76P, HIS121Q, HIS198Q, HIS200Q, HIS221P, HIS225Q, HIS267P, HIS50Q, HIS68P, HIS6Q, ILE116Q, ILE218P, ILE226P, ILE229P, ILE236P, ILE268P, ILE27P, ILE69P, ILE78P, LEU109Q, LEU113Q, LEU17Q, LEU18Q, LEU190Q, LEU206Q, LEU209Q, LEU210Q, LEU214Q, LEU215Q, LEU216Q, LEU218Q, LEU230P, LEU230Q, LEU233P, LEU234P, LEU235P, LEU235Q, LEU237P, LEU239P, LEU241P, LEU242P, LEU244P, LEU249P, LEU262P, LYS202Q, LYS207Q, LYS217P, LYS223Q, LYS226Q, LYS227P, LYS231Q, LYS269P, MET204Q, MET208Q, MET211Q, MET212Q, MET222Q, MET240P, MET43Q, MET82P, PHE220P, PHE245P, PHE63P, PRO111Q, PRO154Q, PRO196Q, PRO217Q, PRO219P, PRO222P, PRO247P, PRO24P, PRO253P, PRO258P, PRO266P, PRO342P, SER114Q, SER19Q, SER228Q, SER25P, SER28P, SER29P, SER64P, SER65P, THR225P, THR257P, THR60P, THR61P, THR67P, TRP192Q, TRP227Q, TRP77P, TYR115Q, TYR220Q, TYR223P, TYR224P, TYR256P, TYR45Q, TYR75P, TYR81P, TYR90Q, VAL117Q, VAL215P, VAL219Q, VAL229Q, VAL243P, VAL46Q, VAL66P, VAL73P
• P-R: ALA50R, ALA64R, ALA66R, ARG71P, ASN53R, ASN74P, ASP67R, ASP72P, GLN57R, GLY48P, GLY76P, HIS54P, HIS68P, HIS83P, ILE226P, ILE229P, ILE236P, ILE45P, ILE69P, ILE78P, ILE79P, LEU233P, LEU244P, LEU43P, LEU46P, LEU49P, LEU51P, LEU69R, MET240P, MET53P, MET62R, MET82P, PHE50P, PHE58R, SER56R, SER60R, SER61R, SER63R, SER65R, THR43R, THR47P, TRP77P, TYR75P, VAL243P, VAL47R, VAL54R, VAL55R, VAL59R, VAL68R, VAL73P
• P-S: ALA23S, ALA24S, ALA369P, ALA65S, ARG17S, ARG313P, ARG318P, ARG33S, ARG58S, ARG61S, ARG64S, ARG71S, ASN206P, ASN207P, ASN22S, ASN26P, ASN27S, ASN374P, ASN40S, ASP214P, ASP216P, ASP34S, ASP35S, ASP56S, ASP67S, ASP86S, CYS323P, GLN312P, GLN322P, GLN72S, GLU14S, GLU373P, GLU39S, GLU84S, GLU91S, GLY105P, GLY15S, GLY210P, GLY25S, GLY370P, HIS308P, HIS38S, ILE16S, ILE211P, ILE218P, ILE27P, ILE372P, ILE37S, ILE47S, ILE62S, ILE74S, ILE98S, LEU110P, LEU13S, LEU29S, LEU31S, LEU320P, LEU376P, LEU377P, LEU66S, LEU68S, LEU90S, LEU94S, LYS18S, LYS217P, LYS227P, LYS28S, LYS311P, LYS375P, LYS378P, LYS44S, LYS63S, LYS87S, MET315P, MET316P, MET32S, MET70S, PHE109P, PHE26S, PHE317P, PHE60S, PRO208P, PRO24P, PRO319P, SER106P, SER212P, SER213P, SER25P, SER28P, SER29P, SER310P, SER314P, SER321P, SER69S, SER88S, THR108P, THR203P, THR209P, THR36S, TRP12S, TRP19S, TRP30P, TRP379P, TYR104P, TYR107P, TYR20S, TYR21S, TYR224P, TYR55S, TYR83S, TYR89S, VAL215P, VAL43S, VAL59S
• P-T: ALA17P, ALA23P, ALA327P, ALA330P, ALA354P, ALA43T, ALA49T, ALA54T, ARG11T, ARG2T, ARG318P, ARG40T, ARG47T, ARG9T, ASN16P, ASP20P, ASP214P, ASP216P, ASP331P, CYS323P, CYS44T, GLN23T, GLN322P, GLN341P, GLN3T, GLN64T, GLU202P, GLU344P, GLU65T, GLU67T, GLY1T, GLY204P, GLY351P, GLY5T, GLY62T, HIS201P, HIS221P, HIS267P, HIS345P, HIS6T, ILE19P, ILE218P, ILE338P, ILE348P, ILE350P, LEU200P, LEU21P, LEU320P, LEU324P, LEU328P, LEU332P, LEU333P, LEU335P, LEU353P, LEU357P, LEU361P, LEU46T, LEU57T, LEU7T, LYS12P, LYS217P, LYS68T, LYS70T, MET315P, MET316P, PHE109P, PHE220P, PHE317P, PHE325P, PHE4T, PHE52T, PHE55T, PHE66T, PRO20T, PRO219P, PRO222P, PRO22P, PRO24P, PRO319P, PRO342P, PRO346P, PRO50T, PRO51T, SER17T, SER205P, SER212P, SER213P, SER28P, SER29P, SER321P, SER69T, THR15T, THR203P, THR334P, THR336P, THR349P, THR60T, THR63T, THR8T, TRP326P, TRP337P, TRP61T, TYR103P, TYR223P, TYR347P, TYR56T, TYR59T, VAL10T, VAL13T, VAL215P, VAL329P, VAL343P, VAL48T, VAL53T, VAL58T
• P-W: PHE245P, TYR43W
• Q-R: ALA221Q, ALA236Q, ALA41R, ALA47Q, ALA48R, ALA50R, ALA51R, ALA66R, ALA70R, ARG14R, ARG15R, ARG224Q, ARG233Q, ARG238Q, ARG32R, ARG49Q, ASN53R, ASP12R, ASP4R, ASP67R, ASP77Q, ASP80R, ASP89Q, ASP9R, GLN57R, GLU75R, GLU76Q, GLY46R, HIS200Q, HIS225Q, HIS2R, HIS50Q, ILE5R, ILE74R, ILE81R, LEU210Q, LEU214Q, LEU215Q, LEU216Q, LEU218Q, LEU230Q, LEU235Q, LEU38R, LEU69R, LEU87Q, LYS207Q, LYS223Q, LYS226Q, LYS231Q, LYS234Q, LYS33R, LYS62Q, LYS6R, LYS73R, LYS77R, LYS86Q, MET204Q, MET208Q, MET211Q, MET212Q, MET222Q, MET71R, MET87R, PHE10R, PHE35R, PHE89R, PRO217Q, PRO8R, SER11R, SER1R, SER228Q, SER232Q, SER36R, SER65R, SER72R, SER79R, SER88Q, THR3R, THR40R, THR42R, THR43R, THR44R, TRP91R, TYR13R, TYR220Q, TYR37R, TYR49R, TYR90Q, VAL219Q, VAL229Q, VAL39R, VAL45R, VAL47R, VAL54R, VAL68R, VAL7R
• Q-S: ALA236Q, ALA65S, ARG224Q, ARG233Q, ARG238Q, ARG58S, ARG61S, ARG64S, ARG71S, ASN53S, ASP56S, ASP57S, ASP67S, GLN72S, GLN73S, GLU52S, ILE62S, LEU230Q, LEU235Q, LEU54S, LEU66S, LEU68S, LYS223Q, LYS231Q, LYS234Q, LYS241Q, LYS63S, MET70S, PHE60S, PRO239Q, PRO240Q, SER228Q, SER232Q, SER69S, TRP227Q, TYR237Q, TYR55S, VAL229Q, VAL59S
• Q-T: ALA221Q, ALA236Q, ALA25T, ARG11T, ARG224Q, ARG233Q, ARG238Q, ARG24T, ARG40T, ARG71T, ASN73T, ASP2Q, GLN23T, GLU22T, GLU4Q, GLU67T, GLY33T, HIS12T, HIS225Q, HIS28T, HIS6Q, ILE14T, LEU18T, LEU216Q, LEU218Q, LEU230Q, LEU235Q, LEU3Q, LYS223Q, LYS226Q, LYS231Q, LYS234Q, LYS70T, LYS72T, MET222Q, PHE21T, PHE26T, PHE66T, PRO20T, PRO217Q, PRO239Q, PRO240Q, PRO27T, SER17T, SER19T, SER228Q, SER232Q, THR15T, TRP227Q, TYR16T, TYR220Q, TYR237Q, TYR29T, VAL10T, VAL13T, VAL219Q, VAL229Q
• Q-U: ALA177Q, ALA183Q, ALA64U, ALA70U, ARG15Q, ARG21U, ARG28Q, ARG43U, ARG47U, ARG65U, ASN150Q, ASN166Q, ASN75U, ASP125Q, ASP15U, ASP173Q, ASP185Q, ASP22Q, ASP2Q, ASP41U, ASP53U, ASP60U, ASP66U, CYS135Q, CYS187Q, CYS40U, CYS54U, CYS68U, GLN156Q, GLN181Q, GLU124Q, GLU136Q, GLU167Q, GLU38U, GLU42U, GLU4Q, GLU51U, GLU52U, GLU56U, GLU57U, GLY133Q, GLY140Q, GLY155Q, GLY174Q, HIS14Q, HIS63U, HIS67U, HIS6Q, HIS71U, ILE164Q, LEU131Q, LEU13U, LEU17U, LEU37U, LEU3Q, LEU58U, LEU59U, LEU5Q, LEU62U, LEU73U, LEU77U, LYS184Q, LYS72U, LYS78U, MET179Q, PHE128Q, PHE149Q, PHE153Q, PHE171Q, PHE61U, PHE74U, PRO11Q, PRO137Q, PRO138Q, PRO151Q, PRO16U, PRO176Q, PRO7Q, PRO8Q, SER129Q, SER13Q, SER142Q, SER180Q, SER1Q, SER25Q, SER45U, SER46U, SER76U, SER9Q, THR132Q, THR139Q, THR175Q, THR178Q, THR188Q, THR18U, THR19U, THR24Q, THR50U, THR55U, TRP12Q, TYR10Q, TYR134Q, TYR152Q, TYR165Q, VAL141Q, VAL14U, VAL168Q, VAL182Q, VAL20U, VAL44U, VAL69U
• Q-W: ALA39W, ALA41W, ALA61Q, ALA63Q, ARG15Q, ARG201Q, ARG203Q, ARG27Q, ARG28Q, ASN47W, ASN61W, ASP172Q, ASP173Q, ASP199Q, ASP22Q, ASP36W, ASP40W, ASP59Q, CYS55Q, GLN31Q, GLN37W, GLU197Q, GLU32W, GLU44W, GLU48W, GLU58Q, GLU60Q, GLU60W, GLY16Q, GLY205Q, GLY213Q, GLY38W, GLY49W, GLY53Q, HIS14Q, HIS198Q, HIS200Q, HIS23Q, HIS45W, HIS54W, HIS57W, ILE26Q, ILE42W, ILE46W, ILE55W, LEU17Q, LEU18Q, LEU206Q, LEU209Q, LEU210Q, LEU214Q, LEU215Q, LEU21Q, LEU51Q, LEU51W, LYS184Q, LYS202Q, LYS207Q, LYS50W, LYS53W, LYS56W, LYS58W, LYS62Q, LYS62W, MET204Q, MET208Q, MET211Q, MET212Q, MET222Q, PHE20W, PHE31W, PHE35W, SER13Q, SER19Q, SER20Q, SER25Q, THR188Q, THR24Q, THR57Q, TRP12Q, TRP52W, TYR43W, TYR56Q, TYR59W, VAL52Q, VAL54Q
• R-S: ARG71S, GLN73S, TYR13R
• R-T: ALA25T, ALA31R, ARG14R, ARG15R, ARG24T, ARG32R, ASP12R, ASP4R, ASP9R, GLN23T, GLU17R, GLU22T, GLY34R, HIS28T, HIS2R, ILE14T, ILE5R, LEU18T, LEU19R, LEU38R, LYS32T, LYS33R, LYS6R, PHE10R, PHE21T, PHE26T, PHE35R, PRO16R, PRO20T, PRO27T, PRO8R, SER11R, SER17T, SER19T, SER25R, SER28R, SER29R, SER36R, THR15T, THR40R, TYR13R, TYR16T, TYR37R, VAL18R, VAL39R, VAL7R
• R-W: ALA21W, ALA28W, ALA31R, ALA39W, ALA41R, ALA48R, ALA50R, ALA7W, ARG15R, ARG15W, ARG32R, ARG33W, ARG8W, ASN53R, ASP36W, GLN37W, GLU17R, GLU27R, GLU30R, GLU32W, GLY27W, GLY34R, GLY46R, ILE24W, LEU12W, LEU13W, LEU29W, LEU38R, LEU5W, LEU9W, LYS33R, LYS52R, PHE14W, PHE20W, PHE30W, PHE31W, PHE35R, PHE35W, PRO3W, SER11W, SER28R, SER29R, SER36R, THR23W, THR40R, THR42R, THR43R, THR44R, THR4W, THR6W, TYR10W, TYR37R, TYR49R, VAL25W, VAL26W, VAL39R, VAL45R, VAL47R
• S-T: ALA23S, ALA24S, ALA43T, ARG11T, ARG2T, ARG39T, ARG40T, ARG47T, ARG48S, ARG64S, ARG71S, ARG9T, ASN22S, ASN36T, ASN53S, ASP56S, ASP57S, ASP67S, GLN72S, GLN73S, GLU52S, GLY25S, GLY33T, HIS12T, ILE14T, ILE47S, ILE74S, LEU29S, LEU46T, LEU68S, LEU75S, LYS28S, LYS32T, LYS44S, LYS63S, PHE60S, PRO27T, SER69S, THR15T, THR8T, TRP19S, TRP80S, TYR20S, TYR55S, VAL10T, VAL13T, VAL37T, VAL59S
• T-U: ALA75T, ARG36U, ARG43U, ARG47U, ARG71T, ASN73T, ASP60U, GLU51U, GLU52U, GLU56U, GLU57U, HIS63U, LEU59U, LYS70T, LYS72T, PRO74T, THR50U, THR55U
• T-W: PHE21T, TYR10W
• U-W: LYS58W, LYS78U