1PCQ

crystal structure of groel-groes

• Total interactions analyzed: 210
• Total true interactions: 42
• Strongest Interaction:
  • Chains: H-I
  • Int. Res.: 185
  • Norm. En. per Res.: -2.8772
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-89.9017	-23.0375	-355.273	-468.2122	185	16	17	16740	2	58	72
A-G	-96.1325	-24.0247	-393.523	-513.6801	188	27	18	17494	2	59	70
A-H	-4.7823	1.9325	-34.6247	-37.4745	40	1	3	1837	0	13	10
A-N	-6.8277	4.0358			3
A-O	-8.5716	2.9414			6
B-C	-95.1368	-22.2332	-379.853	-497.223	188	21	18	17077	2	58	72
B-H	-5.5661	3.6945	-39.0023	-40.8739	21	1	1	1659	3	10	6
B-I	0.0	-4.3599	-24.5091	-28.869	38	0	2	1515	0	13	8
B-P	-5.5823	2.5968			4
C-D	-101.8781	-22.6775	-398.985	-523.5406	189	25	18	17669	2	60	72
C-I	-6.7243	3.8602	-42.1056	-44.9697	21	1	1	1689	4	10	6
C-J	0.0	2.345	-28.5085	-26.1635	39	1	2	1593	0	12	8
C-Q	-4.8929	3.1451			4
D-E	-94.7693	-23.4273	-353.931	-472.1276	183	16	16	16603	2	57	72
D-J	-7.1182	4.0465	-33.1135	-36.1852	21	5	1	1629	4	10	6
D-K	0.0	3.0026	-35.1317	-32.1291	40	1	3	1840	0	13	10
D-R	0.0	3.033			2
E-F	-96.5216	-25.0835	-374.122	-495.7272	186	17	17	16779	2	59	73
E-K	-5.3204	3.5951	-33.8247	-35.55	22	3	1	1653	3	10	6
E-L	0.0	3.5743	-24.6964	-21.1221	38	0	2	1415	0	12	8
E-S	-5.603	2.6468			4
F-G	-96.507	-20.5262	-361.904	-478.9372	182	19	18	16458	2	56	72
F-L	-5.4967	3.8153	-36.2276	-37.909	21	2	1	1576	3	10	6
F-M	0.0	-3.7628	-17.4647	-21.2275	23	0	1	912	0	2	2
F-T	0.0	2.7914			2
G-M	-6.1149	3.7651	0.0	-2.3498	3	0	0	0	0	0	0
G-N	0.0	3.5113			4
G-U	0.0	2.759			2
H-I	-109.6042	-50.9469	-371.728	-532.2791	185	16	9	15910	6	78	81
H-N	-75.0531	-44.1805			30
I-J	-99.3272	-49.4173	-364.786	-513.5304	181	16	10	15916	5	77	80
J-K	-76.3284	-50.512	-323.756	-450.5964	174	11	9	14686	5	75	75
K-L	-104.5296	-45.3639	-359.953	-509.8465	179	13	10	15580	6	76	76
L-M	-127.9043	-46.0045	-243.736	-417.6449	168	13	4	10815	5	72	74
M-N	-120.6803	-45.8521			32
O-P	-54.7851	-38.6675			15
O-U	-43.8308	-34.7494			15
P-Q	-48.6023	-35.6109			15
Q-R	-46.5765	-36.187			15
R-S	-51.8917	-37.787			15
S-T	-49.3453	-37.2384			15
T-U	-50.5583	-38.632			15

Interface residues

• A-B: ALA106A, ALA108A, ALA12A, ALA152B, ALA212B, ALA24B, ALA260B, ALA26B, ALA287A, ALA2A, ALA356A, ALA383B, ALA384B, ALA3A, ALA46B, ALA480B, ALA481B, ALA507A, ALA508A, ALA511A, ALA57B, ALA71A, ALA81A, ALA84A, ARG118A, ARG13A, ARG268B, ARG345A, ARG36B, ARG395B, ARG501A, ARG58B, ASN10A, ASN112A, ASN153B, ASN21B, ASN326B, ASN37B, ASN433A, ASN457B, ASN68A, ASN68B, ASP115A, ASP121A, ASP155B, ASP224A, ASP25B, ASP283A, ASP328B, ASP361A, ASP41B, ASP435A, ASP523A, ASP5A, ASP64B, CYS458B, CYS519A, GLN290A, GLN348A, GLN351A, GLN352A, GLN432A, GLN505A, GLN72A, GLU156B, GLU209B, GLU257B, GLU303A, GLU304A, GLU355A, GLU386B, GLU388B, GLU391B, GLU483B, GLU518A, GLU59B, GLU61A, GLU61B, GLU63B, GLU76A, GLY110A, GLY211B, GLY256B, GLY306A, GLY32B, GLY35B, GLY459B, GLY45B, GLY512A, GLY70A, GLY9A, ILE205B, ILE305A, ILE49B, ILE515A, ILE60B, LEU116A, LEU183B, LEU23B, LEU259B, LEU289A, LEU40B, LEU504A, LEU513A, LEU524A, LEU62B, LYS117A, LYS286A, LYS28B, LYS311A, LYS327B, LYS34B, LYS364A, LYS380B, LYS390B, LYS392B, LYS42B, LYS4A, LYS51B, LYS65A, LYS65B, LYS75A, LYS75B, LYS7A, LYS80A, MET111A, MET114A, MET16A, MET267B, MET307A, MET389B, MET514A, MET520A, MET69A, MET73A, PHE44B, PHE66A, PHE8A, PRO113A, PRO202B, PRO208B, PRO33B, PRO47B, PRO525A, SER154B, SER201B, SER302A, SER358A, SER43B, SER502A, SER509A, SER55B, THR125A, THR181B, THR210B, THR261B, THR30B, THR357A, THR385B, THR482B, THR48B, THR50B, THR516A, THR517A, THR522A, TYR203B, TYR506A, VAL107A, VAL124A, VAL128A, VAL22B, VAL263B, VAL264B, VAL27B, VAL29B, VAL300A, VAL387B, VAL38B, VAL39B, VAL510A, VAL521A, VAL56B, VAL6A, VAL74A, VAL77A
• A-G: ALA106G, ALA108G, ALA12G, ALA152A, ALA212A, ALA24A, ALA260A, ALA26A, ALA287G, ALA2G, ALA347G, ALA356G, ALA383A, ALA384A, ALA3G, ALA46A, ALA480A, ALA481A, ALA507G, ALA508G, ALA511G, ALA57A, ALA71G, ALA81G, ALA84G, ARG118G, ARG13G, ARG268A, ARG345G, ARG36A, ARG395A, ARG501G, ARG58A, ASN10G, ASN112G, ASN153A, ASN21A, ASN326A, ASN37A, ASN433G, ASN457A, ASN68A, ASN68G, ASP115G, ASP121G, ASP155A, ASP224G, ASP25A, ASP283G, ASP328A, ASP361G, ASP41A, ASP435G, ASP523G, ASP5G, ASP64A, CYS458A, CYS519G, GLN290G, GLN348G, GLN351G, GLN352G, GLN432G, GLN505G, GLN72G, GLU156A, GLU209A, GLU257A, GLU303G, GLU304G, GLU355G, GLU386A, GLU388A, GLU391A, GLU483A, GLU518G, GLU59A, GLU61A, GLU61G, GLU63A, GLU67G, GLU76G, GLY110G, GLY211A, GLY256A, GLY306G, GLY32A, GLY344G, GLY35A, GLY459A, GLY45A, GLY512G, GLY70G, GLY9G, ILE205A, ILE305G, ILE49A, ILE515G, ILE60A, LEU116G, LEU183A, LEU23A, LEU259A, LEU40A, LEU504G, LEU513G, LEU524G, LEU62A, LYS117G, LYS132G, LYS207A, LYS286G, LYS28A, LYS311G, LYS327A, LYS34A, LYS364G, LYS390A, LYS392A, LYS42A, LYS4G, LYS51A, LYS65A, LYS65G, LYS75A, LYS75G, LYS7G, LYS80G, MET111G, MET114G, MET16G, MET267A, MET307G, MET389A, MET514G, MET520G, MET69G, MET73G, PHE44A, PHE66G, PHE8G, PRO113G, PRO202A, PRO208A, PRO33A, PRO47A, PRO525G, SER154A, SER201A, SER302G, SER358G, SER43A, SER502G, SER509G, SER55A, THR125G, THR181A, THR210A, THR261A, THR30A, THR357G, THR385A, THR482A, THR48A, THR50A, THR516G, THR517G, THR522G, TYR203A, TYR506G, VAL107G, VAL124G, VAL128G, VAL22A, VAL263A, VAL264A, VAL27A, VAL29A, VAL300G, VAL387A, VAL38A, VAL39A, VAL510G, VAL521G, VAL56A, VAL6G, VAL74G, VAL77G
• A-H: ALA106A, ALA106H, ALA108A, ALA108H, ALA109A, ALA109H, ARG13A, ARG430H, ARG445A, ARG445H, ASN10A, ASN10H, ASN112H, ASN433H, ASN437H, ASP435H, GLU102A, GLU102H, GLU434A, GLU434H, GLY110A, GLY110H, LEU104A, LEU116A, LEU116H, LEU17A, LYS105A, LYS105H, LYS441A, LYS441H, MET111A, MET111H, THR101A, VAL107A, VAL107H, VAL14A, VAL438A, VAL438H, VAL442A, VAL442H
• A-N: ARG452N, GLU461A, GLU461N
• A-O: ARG268A, ASN265A, GLU238A, ILE25O, LEU27O, LYS20O
• B-C: ALA106B, ALA108B, ALA12B, ALA152C, ALA212C, ALA24C, ALA260C, ALA26C, ALA287B, ALA2B, ALA347B, ALA356B, ALA383C, ALA384C, ALA3B, ALA46C, ALA480C, ALA481C, ALA507B, ALA508B, ALA511B, ALA57C, ALA71B, ALA81B, ALA84B, ARG118B, ARG13B, ARG268C, ARG345B, ARG36C, ARG395C, ARG501B, ARG58C, ASN10B, ASN112B, ASN153C, ASN21C, ASN326C, ASN37C, ASN433B, ASN457C, ASN68B, ASN68C, ASP115B, ASP121B, ASP155C, ASP224B, ASP25C, ASP283B, ASP328C, ASP361B, ASP41C, ASP435B, ASP523B, ASP5B, ASP64C, CYS458C, CYS519B, GLN290B, GLN348B, GLN351B, GLN352B, GLN432B, GLN505B, GLN72B, GLU156C, GLU209C, GLU257C, GLU303B, GLU304B, GLU355B, GLU386C, GLU388C, GLU391C, GLU483C, GLU518B, GLU59C, GLU61B, GLU61C, GLU63C, GLU76B, GLY110B, GLY211C, GLY256C, GLY306B, GLY32C, GLY344B, GLY35C, GLY459C, GLY45C, GLY512B, GLY70B, GLY9B, ILE205C, ILE305B, ILE49C, ILE515B, ILE60C, LEU116B, LEU183C, LEU23C, LEU259C, LEU40C, LEU504B, LEU513B, LEU524B, LEU62C, LYS117B, LYS207C, LYS286B, LYS28C, LYS311B, LYS327C, LYS34C, LYS364B, LYS380C, LYS390C, LYS392C, LYS42C, LYS4B, LYS51C, LYS65B, LYS65C, LYS75B, LYS75C, LYS7B, LYS80B, MET111B, MET114B, MET16B, MET267C, MET307B, MET389C, MET514B, MET520B, MET69B, MET73B, PHE44C, PHE66B, PHE8B, PRO113B, PRO202C, PRO208C, PRO33C, PRO47C, PRO525B, SER154C, SER201C, SER302B, SER358B, SER43C, SER502B, SER509B, SER55C, SER79B, THR125B, THR181C, THR210C, THR261C, THR30C, THR357B, THR385C, THR482C, THR48C, THR50C, THR516B, THR517B, THR522B, TYR203C, TYR506B, VAL107B, VAL124B, VAL128B, VAL22C, VAL263C, VAL264C, VAL27C, VAL29C, VAL300B, VAL387C, VAL38C, VAL39C, VAL510B, VAL521B, VAL56C, VAL6B, VAL74B, VAL77B
• B-H: ALA466B, ALA466H, ARG452B, ARG452H, ASN467B, ASN467H, GLU448H, GLU460B, GLU461B, GLU461H, LYS470H, PRO462B, PRO462H, SER463B, SER463H, THR468B, THR468H, VAL464B, VAL464H, VAL465B, VAL465H
• B-I: ALA106B, ALA106I, ALA108B, ALA108I, ALA109B, ALA109I, ARG430I, ARG445B, ARG445I, ASN10B, ASN10I, ASN112I, ASN433I, ASN437I, ASP435I, GLU102B, GLU102I, GLU434B, GLU434I, GLY110B, GLY110I, LEU104B, LEU116I, LEU17B, LYS105B, LYS105I, LYS441B, LYS441I, MET111B, MET111I, THR101B, VAL107B, VAL107I, VAL14B, VAL438B, VAL438I, VAL442B, VAL442I
• B-P: ARG268B, ASN265B, LEU27P, LYS20P
• C-D: ALA106C, ALA108C, ALA12C, ALA152D, ALA212D, ALA24D, ALA260D, ALA26D, ALA287C, ALA2C, ALA347C, ALA356C, ALA383D, ALA384D, ALA3C, ALA46D, ALA480D, ALA481D, ALA507C, ALA508C, ALA511C, ALA57D, ALA71C, ALA81C, ALA84C, ARG118C, ARG13C, ARG268D, ARG345C, ARG36D, ARG395D, ARG501C, ARG58D, ASN10C, ASN112C, ASN153D, ASN21D, ASN326D, ASN37D, ASN433C, ASN457D, ASN68C, ASN68D, ASP115C, ASP121C, ASP155D, ASP224C, ASP25D, ASP283C, ASP328D, ASP361C, ASP41D, ASP435C, ASP523C, ASP5C, ASP64D, CYS458D, CYS519C, GLN290C, GLN348C, GLN351C, GLN352C, GLN432C, GLN505C, GLN72C, GLU156D, GLU209D, GLU257D, GLU303C, GLU304C, GLU355C, GLU386D, GLU388D, GLU391D, GLU483D, GLU518C, GLU59D, GLU61C, GLU61D, GLU63D, GLU67C, GLU76C, GLY110C, GLY211D, GLY256D, GLY306C, GLY32D, GLY344C, GLY35D, GLY459D, GLY45D, GLY512C, GLY70C, GLY9C, ILE205D, ILE305C, ILE49D, ILE515C, ILE60D, LEU116C, LEU183D, LEU23D, LEU259D, LEU40D, LEU504C, LEU513C, LEU524C, LEU62D, LYS117C, LYS207D, LYS286C, LYS28D, LYS311C, LYS327D, LYS34D, LYS364C, LYS380D, LYS390D, LYS392D, LYS42D, LYS4C, LYS51D, LYS65C, LYS65D, LYS75C, LYS75D, LYS7C, LYS80C, MET111C, MET114C, MET16C, MET267D, MET307C, MET389D, MET514C, MET520C, MET69C, MET73C, PHE44D, PHE66C, PHE8C, PRO113C, PRO202D, PRO208D, PRO33D, PRO47D, PRO525C, SER154D, SER201D, SER302C, SER358C, SER43D, SER502C, SER509C, SER55D, SER79C, THR125C, THR181D, THR210D, THR261D, THR30D, THR357C, THR385D, THR482D, THR48D, THR50D, THR516C, THR517C, THR522C, TYR203D, TYR506C, VAL107C, VAL124C, VAL128C, VAL22D, VAL263D, VAL264D, VAL27D, VAL29D, VAL300C, VAL387D, VAL38D, VAL39D, VAL510C, VAL521C, VAL56D, VAL6C, VAL74C, VAL77C
• C-I: ALA466C, ALA466I, ARG452C, ARG452I, ASN467C, ASN467I, GLU448I, GLU460C, GLU461C, GLU461I, LYS470I, PRO462C, PRO462I, SER463C, SER463I, THR468C, THR468I, VAL464C, VAL464I, VAL465C, VAL465I
• C-J: ALA106C, ALA106J, ALA108C, ALA108J, ALA109C, ALA109J, ARG13C, ARG430J, ARG445C, ARG445J, ASN10C, ASN10J, ASN112J, ASN433J, ASN437J, ASP435J, GLU102C, GLU102J, GLU434C, GLU434J, GLY110C, GLY110J, LEU104C, LEU116J, LEU17C, LYS105C, LYS105J, LYS441C, LYS441J, MET111C, MET111J, THR101C, VAL107C, VAL107J, VAL14C, VAL438C, VAL438J, VAL442C, VAL442J
• C-Q: ARG268C, GLU238C, ILE25Q, LYS20Q
• D-E: ALA106D, ALA108D, ALA12D, ALA152E, ALA212E, ALA24E, ALA260E, ALA26E, ALA287D, ALA2D, ALA356D, ALA383E, ALA384E, ALA3D, ALA46E, ALA480E, ALA481E, ALA507D, ALA508D, ALA511D, ALA57E, ALA71D, ALA81D, ALA84D, ARG118D, ARG13D, ARG268E, ARG345D, ARG36E, ARG395E, ARG501D, ARG58E, ASN10D, ASN112D, ASN153E, ASN21E, ASN326E, ASN37E, ASN433D, ASN457E, ASN68D, ASN68E, ASP115D, ASP121D, ASP155E, ASP224D, ASP25E, ASP283D, ASP328E, ASP361D, ASP41E, ASP435D, ASP523D, ASP5D, ASP64E, CYS458E, CYS519D, GLN290D, GLN348D, GLN351D, GLN352D, GLN432D, GLN505D, GLN72D, GLU156E, GLU209E, GLU257E, GLU303D, GLU304D, GLU355D, GLU386E, GLU388E, GLU391E, GLU483E, GLU518D, GLU59E, GLU61E, GLU63E, GLU76D, GLY110D, GLY211E, GLY256E, GLY306D, GLY32E, GLY35E, GLY459E, GLY45E, GLY512D, GLY70D, GLY9D, ILE205E, ILE305D, ILE49E, ILE515D, ILE60E, LEU116D, LEU183E, LEU23E, LEU259E, LEU40E, LEU504D, LEU513D, LEU524D, LEU62E, LYS117D, LYS286D, LYS28E, LYS311D, LYS327E, LYS34E, LYS364D, LYS380E, LYS390E, LYS392E, LYS42E, LYS4D, LYS51E, LYS65D, LYS65E, LYS75D, LYS75E, LYS7D, LYS80D, MET111D, MET114D, MET16D, MET267E, MET307D, MET389E, MET514D, MET520D, MET69D, MET73D, PHE44E, PHE66D, PHE8D, PRO113D, PRO202E, PRO208E, PRO33E, PRO47E, PRO525D, SER154E, SER201E, SER302D, SER358D, SER43E, SER502D, SER509D, SER55E, THR125D, THR181E, THR210E, THR261E, THR30E, THR357D, THR385E, THR482E, THR48E, THR50E, THR516D, THR517D, THR522D, TYR203E, TYR506D, VAL107D, VAL124D, VAL128D, VAL22E, VAL263E, VAL264E, VAL27E, VAL29E, VAL300D, VAL387E, VAL38E, VAL39E, VAL510D, VAL521D, VAL56E, VAL6D, VAL74D, VAL77D
• D-J: ALA466D, ALA466J, ARG452D, ARG452J, ASN467D, ASN467J, GLU448J, GLU460D, GLU461D, GLU461J, LYS470J, PRO462D, PRO462J, SER463D, SER463J, THR468D, THR468J, VAL464D, VAL464J, VAL465D, VAL465J
• D-K: ALA106D, ALA106K, ALA108D, ALA108K, ALA109D, ALA109K, ARG13D, ARG430K, ARG445D, ARG445K, ASN10D, ASN10K, ASN112K, ASN433K, ASN437K, ASP435K, GLU102D, GLU102K, GLU434D, GLU434K, GLY110D, GLY110K, LEU104D, LEU116D, LEU116K, LEU17D, LYS105D, LYS105K, LYS441D, LYS441K, MET111D, MET111K, THR101D, VAL107D, VAL107K, VAL14D, VAL438D, VAL438K, VAL442D, VAL442K
• D-R: ARG268D, LYS20R
• E-F: ALA106E, ALA108E, ALA12E, ALA152F, ALA212F, ALA24F, ALA260F, ALA26F, ALA287E, ALA2E, ALA347E, ALA356E, ALA383F, ALA384F, ALA3E, ALA46F, ALA480F, ALA481F, ALA507E, ALA508E, ALA511E, ALA57F, ALA71E, ALA81E, ALA84E, ARG118E, ARG13E, ARG268F, ARG345E, ARG36F, ARG395F, ARG501E, ARG58F, ASN10E, ASN112E, ASN153F, ASN21F, ASN326F, ASN37F, ASN433E, ASN457F, ASN68E, ASN68F, ASP115E, ASP121E, ASP155F, ASP224E, ASP25F, ASP283E, ASP328F, ASP361E, ASP41F, ASP435E, ASP523E, ASP5E, ASP64F, CYS458F, CYS519E, GLN290E, GLN348E, GLN351E, GLN352E, GLN432E, GLN505E, GLN72E, GLU156F, GLU209F, GLU257F, GLU303E, GLU304E, GLU355E, GLU386F, GLU388F, GLU391F, GLU483F, GLU518E, GLU59F, GLU61E, GLU61F, GLU63F, GLU76E, GLY110E, GLY211F, GLY256F, GLY306E, GLY32F, GLY344E, GLY35F, GLY459F, GLY45F, GLY512E, GLY70E, GLY9E, ILE205F, ILE305E, ILE49F, ILE515E, ILE60F, LEU116E, LEU183F, LEU23F, LEU259F, LEU40F, LEU513E, LEU524E, LEU62F, LYS117E, LYS207F, LYS286E, LYS28F, LYS311E, LYS327F, LYS34F, LYS364E, LYS380F, LYS390F, LYS392F, LYS42F, LYS4E, LYS51F, LYS65E, LYS65F, LYS75E, LYS75F, LYS7E, LYS80E, MET111E, MET114E, MET16E, MET267F, MET307E, MET389F, MET514E, MET520E, MET69E, MET73E, PHE44F, PHE66E, PHE8E, PRO113E, PRO202F, PRO208F, PRO33F, PRO47F, PRO525E, SER154F, SER201F, SER302E, SER358E, SER43F, SER502E, SER509E, SER55F, THR125E, THR181F, THR210F, THR261F, THR30F, THR357E, THR385F, THR482F, THR48F, THR50F, THR516E, THR517E, THR522E, TYR203F, TYR506E, VAL107E, VAL124E, VAL128E, VAL22F, VAL263F, VAL264F, VAL27F, VAL29F, VAL300E, VAL387F, VAL38F, VAL39F, VAL510E, VAL521E, VAL56F, VAL6E, VAL74E, VAL77E
• E-K: ALA466E, ALA466K, ARG452E, ARG452K, ASN467E, ASN467K, GLU448K, GLU460E, GLU461E, GLU461K, LYS470K, PRO462E, PRO462K, SER463E, SER463K, THR468E, THR468K, TYR485E, VAL464E, VAL464K, VAL465E, VAL465K
• E-L: ALA106E, ALA106L, ALA108E, ALA108L, ALA109E, ALA109L, ARG430L, ARG445E, ARG445L, ASN10E, ASN10L, ASN112L, ASN433L, ASN437L, ASP435L, GLU102E, GLU102L, GLU434E, GLU434L, GLY110E, GLY110L, LEU104E, LEU116L, LEU17E, LYS105E, LYS105L, LYS441E, LYS441L, MET111E, MET111L, THR101E, VAL107E, VAL107L, VAL14E, VAL438E, VAL438L, VAL442E, VAL442L
• E-S: ARG268E, ASN265E, LEU27S, LYS20S
• F-G: ALA108F, ALA12F, ALA152G, ALA24G, ALA260G, ALA26G, ALA287F, ALA2F, ALA356F, ALA383G, ALA384G, ALA3F, ALA46G, ALA480G, ALA481G, ALA507F, ALA508F, ALA511F, ALA57G, ALA71F, ALA81F, ALA84F, ARG118F, ARG13F, ARG268G, ARG345F, ARG36G, ARG395G, ARG501F, ARG58G, ASN10F, ASN112F, ASN153G, ASN21G, ASN326G, ASN37G, ASN433F, ASN457G, ASN68F, ASN68G, ASP115F, ASP121F, ASP155G, ASP224F, ASP25G, ASP283F, ASP328G, ASP361F, ASP41G, ASP435F, ASP523F, ASP5F, ASP64G, CYS458G, CYS519F, GLN290F, GLN348F, GLN351F, GLN352F, GLN432F, GLN505F, GLN72F, GLU156G, GLU209G, GLU257G, GLU303F, GLU304F, GLU355F, GLU386G, GLU388G, GLU391G, GLU483G, GLU518F, GLU59G, GLU61F, GLU61G, GLU63G, GLU76F, GLY110F, GLY211G, GLY256G, GLY306F, GLY32G, GLY35G, GLY459G, GLY45G, GLY512F, GLY70F, GLY9F, ILE205G, ILE305F, ILE49G, ILE515F, ILE60G, LEU116F, LEU183G, LEU23G, LEU259G, LEU40G, LEU513F, LEU524F, LEU62G, LYS117F, LYS286F, LYS28G, LYS311F, LYS327G, LYS34G, LYS364F, LYS380G, LYS390G, LYS392G, LYS42G, LYS4F, LYS51G, LYS65F, LYS65G, LYS75F, LYS75G, LYS7F, LYS80F, MET111F, MET114F, MET16F, MET267G, MET307F, MET389G, MET514F, MET520F, MET69F, MET73F, PHE204G, PHE44G, PHE66F, PHE8F, PRO113F, PRO202G, PRO208G, PRO33G, PRO47G, PRO525F, SER154G, SER201G, SER302F, SER358F, SER43G, SER502F, SER509F, SER55G, THR125F, THR181G, THR210G, THR261G, THR30G, THR357F, THR385G, THR482G, THR48G, THR50G, THR516F, THR517F, THR522F, TYR203G, TYR506F, VAL107F, VAL124F, VAL128F, VAL22G, VAL263G, VAL264G, VAL27G, VAL29G, VAL300F, VAL387G, VAL38G, VAL39G, VAL510F, VAL521F, VAL56G, VAL6F, VAL74F, VAL77F
• F-L: ALA466F, ALA466L, ARG452F, ARG452L, ASN467F, ASN467L, GLU448L, GLU460F, GLU461F, GLU461L, LYS470L, PRO462F, PRO462L, SER463F, SER463L, THR468F, THR468L, VAL464F, VAL464L, VAL465F, VAL465L
• F-M: ALA106F, ALA106M, ALA108F, ALA108M, ALA109F, ALA109M, ASN10F, ASN112M, ASP435M, GLU102F, GLU102M, GLY110F, GLY110M, LEU104F, LEU116M, LEU17F, LYS105F, LYS105M, MET111M, THR101F, VAL107F, VAL107M, VAL14F
• F-T: ARG268F, LYS20T
• G-M: ARG452M, GLU461G, GLU461M
• G-N: ASP435N, GLU434G, GLU434N, LYS105G
• G-U: ARG268G, LYS20U
• H-I: ALA12I, ALA239H, ALA241H, ALA243H, ALA24H, ALA258I, ALA260I, ALA26H, ALA278I, ALA2I, ALA383H, ALA384H, ALA3I, ALA46H, ALA480H, ALA481H, ALA511I, ALA57H, ALA71I, ARG118I, ARG13I, ARG18H, ARG197I, ARG231I, ARG268H, ARG284I, ARG285I, ARG322H, ARG36H, ARG58H, ASN112I, ASN206H, ASN21H, ASN229I, ASN265H, ASN37H, ASN433I, ASN457H, ASN68H, ASN68I, ASP115I, ASP179H, ASP253I, ASP25H, ASP283I, ASP361I, ASP41H, ASP523I, ASP5I, ASP64H, CYS458H, CYS519I, GLN184H, GLN432I, GLN453H, GLN72I, GLU186H, GLU216H, GLU232I, GLU238H, GLU252I, GLU255I, GLU257I, GLU303I, GLU308I, GLU310I, GLU386H, GLU388H, GLU460H, GLU461H, GLU483H, GLU518I, GLU59H, GLU61H, GLU63H, GLU76I, GLY180H, GLY182H, GLY244H, GLY256I, GLY269H, GLY280I, GLY282I, GLY35H, GLY382H, GLY459H, GLY45H, GLY512I, GLY70I, GLY9I, ILE227I, ILE230I, ILE270H, ILE49H, ILE515I, ILE60H, LEU183H, LEU237H, LEU23H, LEU259I, LEU40H, LEU456H, LEU513I, LEU524I, LEU62H, LYS117I, LYS207H, LYS225I, LYS226I, LYS242H, LYS245H, LYS272H, LYS277I, LYS286I, LYS28H, LYS311I, LYS34H, LYS364I, LYS390H, LYS42H, LYS4I, LYS51H, LYS65H, LYS65I, LYS75H, LYS75I, LYS7I, LYS80I, MET111I, MET114I, MET16I, MET267H, MET389H, MET514I, MET520I, MET69I, MET73I, PHE281I, PHE44H, PHE66I, PHE8I, PRO113I, PRO246H, PRO33H, PRO47H, PRO525I, SER217H, SER228I, SER358I, SER43H, SER509I, SER55H, SER79I, THR181H, THR261I, THR266H, THR30H, THR357I, THR385H, THR48H, THR50H, THR516I, THR517I, THR522I, TYR203I, TYR360I, VAL107I, VAL20H, VAL22H, VAL240H, VAL264I, VAL271H, VAL27H, VAL29H, VAL381H, VAL387H, VAL38H, VAL39H, VAL455H, VAL510I, VAL521I, VAL56H, VAL6I, VAL74I, VAL77I
• H-N: ALA2H, ARG197H, ARG231H, ARG268N, ARG285H, ARG36N, ASP25N, ASP41N, ASP523H, ASP5H, CYS519H, GLU216N, GLU255H, GLU257H, GLU310H, GLU386N, GLU518H, GLU59N, GLU61N, GLU63N, LYS226H, LYS242N, LYS272N, LYS277H, LYS28N, LYS4H, LYS65H, THR522H, VAL39N, VAL521H
• I-J: ALA12J, ALA241I, ALA243I, ALA24I, ALA258J, ALA260J, ALA26I, ALA278J, ALA2J, ALA383I, ALA384I, ALA3J, ALA46I, ALA480I, ALA481I, ALA511J, ALA57I, ALA71J, ARG118J, ARG13J, ARG197J, ARG231J, ARG268I, ARG284J, ARG285J, ARG322I, ARG36I, ARG58I, ASN112J, ASN206I, ASN21I, ASN229J, ASN265I, ASN37I, ASN457I, ASN68I, ASN68J, ASP115J, ASP179I, ASP253J, ASP25I, ASP283J, ASP361J, ASP41I, ASP523J, ASP5J, ASP64I, CYS458I, CYS519J, GLN184I, GLN432J, GLN453I, GLN72J, GLU216I, GLU232J, GLU238I, GLU252J, GLU255J, GLU257J, GLU303J, GLU308J, GLU310J, GLU386I, GLU388I, GLU460I, GLU461I, GLU483I, GLU518J, GLU59I, GLU61I, GLU61J, GLU63I, GLU76J, GLY180I, GLY182I, GLY244I, GLY256J, GLY269I, GLY280J, GLY282J, GLY35I, GLY382I, GLY459I, GLY45I, GLY512J, GLY70J, GLY9J, ILE227J, ILE230J, ILE270I, ILE49I, ILE515J, ILE60I, LEU183I, LEU215I, LEU237I, LEU23I, LEU259J, LEU40I, LEU456I, LEU513J, LEU524J, LEU62I, LYS117J, LYS207I, LYS225J, LYS226J, LYS242I, LYS245I, LYS272I, LYS277J, LYS286J, LYS28I, LYS311J, LYS34I, LYS364J, LYS390I, LYS42I, LYS4J, LYS51I, LYS65I, LYS65J, LYS75I, LYS75J, LYS7J, LYS80J, MET111J, MET114J, MET16J, MET267I, MET389I, MET514J, MET520J, MET69J, MET73J, PHE281J, PHE44I, PHE66J, PHE8J, PRO113J, PRO246I, PRO279J, PRO33I, PRO47I, PRO525J, SER228J, SER358J, SER43I, SER509J, SER55I, SER79J, THR181I, THR261J, THR266I, THR30I, THR357J, THR385I, THR48I, THR50I, THR516J, THR517J, THR522J, TYR203J, TYR360J, VAL107J, VAL22I, VAL240I, VAL264J, VAL271I, VAL27I, VAL29I, VAL381I, VAL387I, VAL38I, VAL39I, VAL510J, VAL521J, VAL56I, VAL6J, VAL74J, VAL77J
• J-K: ALA12K, ALA241J, ALA243J, ALA24J, ALA258K, ALA260K, ALA26J, ALA278K, ALA2K, ALA383J, ALA384J, ALA3K, ALA46J, ALA57J, ALA71K, ARG118K, ARG13K, ARG197K, ARG231K, ARG268J, ARG284K, ARG285K, ARG322J, ARG36J, ARG58J, ASN112K, ASN206J, ASN21J, ASN229K, ASN265J, ASN37J, ASN457J, ASN68J, ASN68K, ASP115K, ASP179J, ASP253K, ASP25J, ASP283K, ASP361K, ASP41J, ASP523K, ASP5K, ASP64J, CYS458J, CYS519K, GLN184J, GLN432K, GLN453J, GLN72K, GLU216J, GLU232K, GLU238J, GLU252K, GLU255K, GLU257K, GLU303K, GLU308K, GLU310K, GLU386J, GLU388J, GLU460J, GLU483J, GLU518K, GLU59J, GLU61J, GLU61K, GLU63J, GLU76K, GLY180J, GLY182J, GLY244J, GLY256K, GLY269J, GLY280K, GLY282K, GLY35J, GLY382J, GLY459J, GLY45J, GLY512K, GLY70K, GLY9K, ILE227K, ILE230K, ILE270J, ILE49J, ILE515K, ILE60J, LEU183J, LEU215J, LEU237J, LEU23J, LEU259K, LEU40J, LEU456J, LEU513K, LEU524K, LEU62J, LYS117K, LYS207J, LYS225K, LYS226K, LYS242J, LYS245J, LYS272J, LYS277K, LYS286K, LYS28J, LYS311K, LYS34J, LYS364K, LYS390J, LYS42J, LYS4K, LYS51J, LYS65J, LYS65K, LYS75J, LYS75K, LYS7K, LYS80K, MET114K, MET16K, MET267J, MET389J, MET514K, MET520K, MET69K, MET73K, PHE281K, PHE44J, PHE66K, PHE8K, PRO113K, PRO246J, PRO47J, PRO525K, SER228K, SER358K, SER43J, SER509K, SER55J, SER79K, THR181J, THR261K, THR266J, THR30J, THR357K, THR385J, THR48J, THR50J, THR516K, THR517K, THR522K, TYR203K, TYR360K, VAL107K, VAL22J, VAL240J, VAL264K, VAL271J, VAL27J, VAL29J, VAL381J, VAL387J, VAL38J, VAL39J, VAL510K, VAL521K, VAL56J, VAL6K, VAL74K, VAL77K
• K-L: ALA12L, ALA241K, ALA243K, ALA24K, ALA258L, ALA260L, ALA26K, ALA278L, ALA2L, ALA383K, ALA384K, ALA3L, ALA46K, ALA480K, ALA481K, ALA57K, ALA71L, ARG118L, ARG13L, ARG197L, ARG231L, ARG268K, ARG284L, ARG285L, ARG322K, ARG36K, ARG58K, ASN112L, ASN206K, ASN21K, ASN229L, ASN265K, ASN37K, ASN457K, ASN68K, ASN68L, ASP115L, ASP179K, ASP253L, ASP25K, ASP283L, ASP361L, ASP41K, ASP523L, ASP5L, ASP64K, CYS458K, CYS519L, GLN184K, GLN432L, GLN453K, GLN72L, GLU216K, GLU232L, GLU238K, GLU252L, GLU255L, GLU257L, GLU303L, GLU308L, GLU310L, GLU386K, GLU388K, GLU460K, GLU461K, GLU483K, GLU518L, GLU59K, GLU61K, GLU63K, GLU76L, GLY180K, GLY182K, GLY244K, GLY256L, GLY269K, GLY280L, GLY282L, GLY35K, GLY382K, GLY459K, GLY45K, GLY512L, GLY70L, GLY9L, ILE227L, ILE230L, ILE270K, ILE49K, ILE515L, ILE60K, LEU183K, LEU215K, LEU237K, LEU23K, LEU259L, LEU40K, LEU456K, LEU513L, LEU524L, LEU62K, LYS117L, LYS207K, LYS225L, LYS226L, LYS242K, LYS245K, LYS272K, LYS277L, LYS286L, LYS28K, LYS311L, LYS34K, LYS364L, LYS390K, LYS42K, LYS4L, LYS51K, LYS65K, LYS65L, LYS75K, LYS75L, LYS7L, LYS80L, MET111L, MET114L, MET16L, MET267K, MET389K, MET514L, MET520L, MET69L, MET73L, PHE281L, PHE44K, PHE66L, PHE8L, PRO113L, PRO246K, PRO33K, PRO47K, PRO525L, SER217K, SER228L, SER358L, SER43K, SER509L, SER55K, SER79L, THR181K, THR261L, THR266K, THR30K, THR357L, THR385K, THR48K, THR50K, THR516L, THR517L, THR522L, TYR203L, TYR360L, VAL107L, VAL22K, VAL240K, VAL264L, VAL271K, VAL27K, VAL29K, VAL381K, VAL387K, VAL38K, VAL39K, VAL510L, VAL521L, VAL56K, VAL6L, VAL74L, VAL77L
• L-M: ALA12M, ALA239L, ALA241L, ALA243L, ALA24L, ALA258M, ALA260M, ALA26L, ALA278M, ALA2M, ALA383L, ALA384L, ALA3M, ALA46L, ALA480L, ALA481L, ALA57L, ALA71M, ARG118M, ARG13M, ARG18L, ARG197M, ARG231M, ARG268L, ARG284M, ARG285M, ARG322L, ARG36L, ARG58L, ASN112M, ASN206L, ASN21L, ASN229M, ASN265L, ASN37L, ASN457L, ASN68L, ASN68M, ASP115M, ASP179L, ASP253M, ASP25L, ASP283M, ASP361M, ASP41L, ASP523M, ASP5M, ASP64L, CYS458L, CYS519M, GLN184L, GLN72M, GLU186L, GLU216L, GLU232M, GLU238L, GLU252M, GLU255M, GLU257M, GLU303M, GLU308M, GLU310M, GLU386L, GLU388L, GLU460L, GLU461L, GLU483L, GLU518M, GLU59L, GLU61L, GLU61M, GLU63L, GLU76M, GLY180L, GLY182L, GLY244L, GLY256M, GLY269L, GLY280M, GLY282M, GLY35L, GLY382L, GLY459L, GLY45L, GLY70M, GLY9M, ILE227M, ILE230M, ILE270L, ILE49L, ILE60L, LEU183L, LEU237L, LEU23L, LEU259M, LEU40L, LEU456L, LEU62L, LYS117M, LYS207L, LYS225M, LYS226M, LYS242L, LYS245L, LYS272L, LYS277M, LYS286M, LYS28L, LYS311M, LYS34L, LYS364M, LYS390L, LYS42L, LYS4M, LYS51L, LYS65L, LYS65M, LYS75L, LYS75M, LYS7M, LYS80M, MET111M, MET114M, MET16M, MET267L, MET389L, MET69M, MET73M, PHE281M, PHE44L, PHE66M, PHE8M, PRO113M, PRO246L, PRO33L, PRO47L, SER217L, SER228M, SER358M, SER43L, SER79M, THR181L, THR261M, THR266L, THR357M, THR385L, THR48L, THR516M, THR522M, TYR203M, TYR360M, VAL107M, VAL20L, VAL22L, VAL240L, VAL264M, VAL271L, VAL27L, VAL29L, VAL381L, VAL387L, VAL38L, VAL39L, VAL521M, VAL56L, VAL6M, VAL74M, VAL77M
• M-N: ARG197N, ARG231N, ARG268M, ARG285N, ARG36M, ASN37M, ASP25M, ASP41M, ASP523N, ASP5N, CYS519N, GLU216M, GLU255N, GLU257N, GLU310N, GLU386M, GLU518N, GLU59M, GLU61M, GLU63M, LEU513N, LYS226N, LYS242M, LYS272M, LYS277N, LYS28M, LYS4N, LYS65N, THR516N, THR522N, VAL39M, VAL521N
• O-P: ARG37O, ARG4P, ASN51P, ASP58O, GLU50O, GLU50P, GLU76P, GLU88O, GLU96O, HIS7P, ILE94O, LEU6P, LEU92O, LYS55O, LYS77P
• O-U: ARG37U, ARG4O, ASN51O, ASP58U, GLU50O, GLU50U, GLU76O, GLU88U, GLU96U, HIS7O, ILE94U, LEU6O, LEU92U, LYS55U, LYS77O
• P-Q: ARG37P, ARG4Q, ASN51Q, ASP58P, GLU50P, GLU50Q, GLU76Q, GLU88P, GLU96P, HIS7Q, ILE94P, LEU6Q, LEU92P, LYS55P, LYS77Q
• Q-R: ARG37Q, ARG4R, ASN51R, ASP58Q, GLU50Q, GLU50R, GLU76R, GLU88Q, GLU96Q, HIS7R, ILE94Q, LEU6R, LEU92Q, LYS55Q, LYS77R
• R-S: ARG37R, ARG4S, ASN51S, ASP58R, GLU50R, GLU50S, GLU76S, GLU88R, GLU96R, HIS7S, ILE94R, LEU6S, LEU92R, LYS55R, LYS77S
• S-T: ARG37S, ARG4T, ASN51T, ASP58S, GLU50S, GLU50T, GLU76T, GLU88S, GLU96S, HIS7T, ILE94S, LEU6T, LEU92S, LYS55S, LYS77T
• T-U: ARG37T, ARG4U, ASN51U, ASP58T, GLU50T, GLU50U, GLU76U, GLU88T, GLU96T, HIS7U, ILE94T, LEU6U, LEU92T, LYS55T, LYS77U