1PCF

human transcriptional coactivator pc4 c-terminal domain

• Total interactions analyzed: 28
• Total true interactions: 18
• Strongest Interaction:
  • Chains: E-F
  • Int. Res.: 108
  • Norm. En. per Res.: -4.4564
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-22.8641	-18.0988	-412.78	-453.7429	108	13	30	18520	4	40	38
A-C	0.0	-3.0517	-0.9	-3.9517	15	0	0	144	0	12	3
A-D	-4.0314	-11.4553	-29.3706	-44.8572	22	1	0	1266	2	8	10
A-G	0.0	0.0	-0.2365	-0.2365	6	0	0	82	0	0	0
B-C	0.0	0.0	-0.4344	-0.4344	5	0	0	104	0	3	3
B-D	-9.7445	23.3093	-38.5229	-24.9581	21	0	0	1139	1	10	10
B-G	0.0	-4.2835	-1.2046	-5.4881	6	0	0	118	0	7	7
C-D	-24.9295	-17.278	-423.935	-466.1425	108	9	31	18531	4	40	37
C-E	0.0	-4.6691	-3.5016	-8.1707	9	0	0	211	0	6	3
C-F	-10.6573	-9.8638	-26.7312	-47.2523	21	1	0	1139	3	7	8
D-E	0.0	0.0	-0.6805	-0.6805	5	0	0	141	0	2	3
D-F	-8.6804	21.7222	-41.8184	-28.7766	21	0	0	1198	2	12	10
E-F	-36.7693	-19.8978	-424.624	-481.2911	108	11	28	18504	4	40	37
E-G	0.0	-4.8258	-4.5018	-9.3276	15	0	0	274	0	9	4
E-H	-9.1476	-24.4744	-37.5396	-71.1615	23	4	0	1452	3	9	10
F-G	0.0	0.0	-0.5957	-0.5957	6	0	0	131	0	2	4
F-H	-8.6827	18.7134	-40.8739	-30.8432	20	0	0	1188	2	11	10
G-H	-38.9152	-16.5977	-405.623	-461.1359	108	9	28	18206	4	40	37

Interface residues

• A-B: ALA123A, ALA123B, ALA62A, ALA62B, ARG100A, ARG100B, ARG125A, ARG125B, ARG70A, ARG70B, ARG75A, ARG75B, ARG86A, ARG86B, ASN106A, ASN106B, ASP119A, ASP119B, ASP121A, ASP121B, ASP122A, ASP122B, ASP76A, ASP76B, ASP84A, ASP84B, GLN109A, GLN109B, GLN112A, GLN112B, GLN116A, GLN116B, GLN65A, GLN65B, GLU108A, GLU108B, GLU115A, GLU115B, GLU87A, GLU87B, GLY102A, GLY102B, GLY67A, GLY67B, GLY79A, GLY79B, ILE103A, ILE103B, ILE117A, ILE117B, ILE120A, ILE120B, ILE66A, ILE66B, ILE83A, ILE83B, ILE85A, ILE85B, LEU105A, LEU105B, LEU113A, LEU113B, LEU127A, LEU127B, LEU82A, LEU82B, LYS101A, LYS101B, LYS114A, LYS114B, LYS126A, LYS126B, LYS68A, LYS68B, LYS80A, LYS80B, MET63A, MET63B, MET69A, MET69B, PHE64A, PHE64B, PHE77A, PHE77B, PRO107A, PRO107B, SER104A, SER104B, SER111A, SER111B, SER118A, SER118B, SER73A, SER73B, TRP110A, TRP110B, TYR71A, TYR71B, TYR88A, TYR88B, VAL124A, VAL124B, VAL72A, VAL72B, VAL74A, VAL74B, VAL81A, VAL81B
• A-C: ARG125A, ARG125C, ASP119A, ASP122A, GLN65C, GLU108A, GLU115A, GLY67C, ILE66C, LEU127C, LYS68C, PRO107A, SER111A, SER118A, VAL124C
• A-D: ASN106D, ASP119A, GLN109D, GLN112A, GLN112D, GLN116A, GLU108A, GLU108D, GLU115A, GLU115D, GLY79D, ILE117A, LEU113A, LYS114A, LYS80D, PRO107A, PRO107D, SER111A, SER111D, SER118A, TRP110A, VAL81D
• A-G: ARG125G, ASP122G, GLN65A, LYS126G, MET63A, PHE64A
• B-C: ARG125B, GLN65C, ILE66C, PHE64C, VAL124B
• B-D: ARG125B, ASP119B, ASP119D, ASP121B, ASP122B, GLN112D, GLN116D, GLN65B, GLU108D, GLU115D, ILE117B, ILE117D, ILE120B, LEU113D, LYS114D, LYS126B, LYS80D, PHE64B, SER111D, SER118B, VAL124B
• B-G: ARG125G, ASP119B, ASP122B, ASP122G, GLN116B, LYS126G
• C-D: ALA123C, ALA123D, ALA62C, ALA62D, ARG100C, ARG100D, ARG125C, ARG125D, ARG70C, ARG70D, ARG75C, ARG75D, ARG86C, ARG86D, ASN106C, ASN106D, ASP119C, ASP119D, ASP121C, ASP121D, ASP122C, ASP122D, ASP76C, ASP76D, ASP84C, ASP84D, GLN109C, GLN109D, GLN112C, GLN112D, GLN116C, GLN116D, GLN65C, GLN65D, GLU108C, GLU108D, GLU115C, GLU115D, GLU87C, GLU87D, GLY102C, GLY102D, GLY67C, GLY67D, GLY79C, GLY79D, ILE103C, ILE103D, ILE117C, ILE117D, ILE120C, ILE120D, ILE66C, ILE66D, ILE83C, ILE83D, ILE85C, ILE85D, LEU105C, LEU105D, LEU113C, LEU113D, LEU127C, LEU127D, LEU82C, LEU82D, LYS101C, LYS101D, LYS114C, LYS114D, LYS126C, LYS126D, LYS68C, LYS68D, LYS80C, LYS80D, MET63C, MET63D, MET69C, MET69D, PHE64C, PHE64D, PHE77C, PHE77D, PRO107C, PRO107D, SER104C, SER104D, SER111C, SER111D, SER118C, SER118D, SER73C, SER73D, TRP110C, TRP110D, TYR71C, TYR71D, TYR88C, TYR88D, VAL124C, VAL124D, VAL72C, VAL72D, VAL74C, VAL74D, VAL81C, VAL81D
• C-E: GLN112C, GLN65E, GLU108C, GLU115C, GLY67E, ILE66E, LYS68E, PRO107C, SER111C
• C-F: ASN106F, ASP119C, GLN109F, GLN112C, GLN112F, GLN116C, GLU108C, GLU108F, GLU115C, GLU115F, GLY79F, ILE117C, LEU113C, LYS114C, LYS80F, PRO107F, SER111C, SER111F, SER118C, TRP110C, VAL81F
• D-E: ARG125D, GLN65E, ILE66E, PHE64E, VAL124D
• D-F: ARG125D, ASP119D, ASP119F, ASP121D, ASP122D, GLN112F, GLN116F, GLU108F, GLU115F, ILE117D, ILE117F, ILE120D, ILE120F, LEU113F, LYS114F, LYS126D, LYS80F, PHE64D, SER111F, SER118D, VAL124D
• E-F: ALA123E, ALA123F, ALA62E, ALA62F, ARG100E, ARG100F, ARG125E, ARG125F, ARG70E, ARG70F, ARG75E, ARG75F, ARG86E, ARG86F, ASN106E, ASN106F, ASP119E, ASP119F, ASP121E, ASP121F, ASP122E, ASP122F, ASP76E, ASP76F, ASP84E, ASP84F, GLN109E, GLN109F, GLN112E, GLN112F, GLN116E, GLN116F, GLN65E, GLN65F, GLU108E, GLU108F, GLU115E, GLU115F, GLU87E, GLU87F, GLY102E, GLY102F, GLY67E, GLY67F, GLY79E, GLY79F, ILE103E, ILE103F, ILE117E, ILE117F, ILE120E, ILE120F, ILE66E, ILE66F, ILE83E, ILE83F, ILE85E, ILE85F, LEU105E, LEU105F, LEU113E, LEU113F, LEU127E, LEU127F, LEU82E, LEU82F, LYS101E, LYS101F, LYS114E, LYS114F, LYS126E, LYS126F, LYS68E, LYS68F, LYS80E, LYS80F, MET63E, MET63F, MET69E, MET69F, PHE64E, PHE64F, PHE77E, PHE77F, PRO107E, PRO107F, SER104E, SER104F, SER111E, SER111F, SER118E, SER118F, SER73E, SER73F, TRP110E, TRP110F, TYR71E, TYR71F, TYR88E, TYR88F, VAL124E, VAL124F, VAL72E, VAL72F, VAL74E, VAL74F, VAL81E, VAL81F
• E-G: ARG125G, ASP122E, GLN112E, GLN65G, GLU108E, GLU115E, GLY67G, ILE66G, LEU127G, LYS114E, LYS68G, PRO107E, SER111E, SER118E, VAL124G
• E-H: ASN106H, ASP119E, GLN109H, GLN112E, GLN112H, GLN116E, GLU108E, GLU108H, GLU115E, GLU115H, GLY79H, ILE117E, LEU113E, LYS114E, LYS80H, PRO107E, PRO107H, SER111E, SER111H, SER118E, TRP110E, TRP110H, VAL81H
• F-G: ARG125F, GLN65G, ILE66G, MET63G, PHE64G, VAL124F
• F-H: ARG125F, ASP119F, ASP119H, ASP121F, ASP122F, GLN112H, GLN116H, GLN65F, GLU108H, GLU115H, ILE117F, ILE117H, ILE120F, LEU113H, LYS114H, LYS80H, PHE64F, SER111H, SER118F, VAL124F
• G-H: ALA123G, ALA123H, ALA62G, ALA62H, ARG100G, ARG100H, ARG125G, ARG125H, ARG70G, ARG70H, ARG75G, ARG75H, ARG86G, ARG86H, ASN106G, ASN106H, ASP119G, ASP119H, ASP121G, ASP121H, ASP122G, ASP122H, ASP76G, ASP76H, ASP84G, ASP84H, GLN109G, GLN109H, GLN112G, GLN112H, GLN116G, GLN116H, GLN65G, GLN65H, GLU108G, GLU108H, GLU115G, GLU115H, GLU87G, GLU87H, GLY102G, GLY102H, GLY67G, GLY67H, GLY79G, GLY79H, ILE103G, ILE103H, ILE117G, ILE117H, ILE120G, ILE120H, ILE66G, ILE66H, ILE83G, ILE83H, ILE85G, ILE85H, LEU105G, LEU105H, LEU113G, LEU113H, LEU127G, LEU127H, LEU82G, LEU82H, LYS101G, LYS101H, LYS114G, LYS114H, LYS126G, LYS126H, LYS68G, LYS68H, LYS80G, LYS80H, MET63G, MET63H, MET69G, MET69H, PHE64G, PHE64H, PHE77G, PHE77H, PRO107G, PRO107H, SER104G, SER104H, SER111G, SER111H, SER118G, SER118H, SER73G, SER73H, TRP110G, TRP110H, TYR71G, TYR71H, TYR88G, TYR88H, VAL124G, VAL124H, VAL72G, VAL72H, VAL74G, VAL74H, VAL81G, VAL81H