1P3H

crystal structure of the mycobacterium tuberculosis chaperonin 10 tetradecamer

• Total interactions analyzed: 91
• Total true interactions: 42
• Strongest Interaction:
  • Chains: A-G
  • Int. Res.: 70
  • Norm. En. per Res.: -3.9252
• Hub Node: A(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-57.0559	101.863	-175.093	-130.286	74	12	9	7609	3	36	36
A-C	0.0	11.1724	-0.1539	11.0185	3	0	0	19	0	0	8
A-F	0.0	8.4024	-0.0826	8.3199	2	0	0	9	0	0	7
A-G	-84.9181	-8.2066	-181.639	-274.7636	70	15	10	7776	3	30	34
A-I	-51.5937	-23.7604	-161.656	-237.0102	73	17	8	7365	4	17	18
A-J	-22.7647	59.4312	-175.424	-138.7575	72	21	2	7827	0	16	23
B-C	-50.0952	119.4188	-178.601	-109.2775	73	14	10	7751	2	39	36
B-D	0.0	0.0	-0.0075	-0.0075	2	0	0	1	0	0	6
B-G	0.0	0.0	-0.0176	-0.0176	2	0	0	2	0	0	5
B-H	-57.2233	-6.0468	-147.457	-210.7271	69	12	9	7013	1	18	19
B-I	-14.4342	12.6826	-152.361	-154.1126	73	15	2	7277	0	16	23
C-D	-80.1417	25.3617	-158.33	-213.11	68	10	10	7179	4	32	36
C-H	-9.4495	39.9431	-165.587	-135.0934	72	19	2	7672	0	16	22
C-N	-49.5195	-17.4596	-159.737	-226.7161	75	21	8	7333	2	17	19
D-E	-58.7246	65.5282	-165.024	-158.2204	72	11	10	7706	0	34	37
D-F	0.0	0.0	-0.4717	-0.4717	2	0	0	15	0	0	6
D-M	-51.5377	-22.4327	-142.476	-216.4464	74	11	8	6936	3	19	20
D-N	-31.1937	17.1801	-186.827	-200.8406	76	26	2	8267	1	16	22
E-F	-43.0765	85.0585	-155.387	-113.4049	72	8	9	7204	3	38	37
E-G	0.0	0.0	-0.1655	-0.1655	3	0	0	9	0	0	7
E-L	-61.4596	-20.7507	-167.166	-249.3763	73	21	10	7544	2	20	19
E-M	-25.8705	41.2573	-148.651	-133.2643	71	15	2	6911	0	16	21
F-G	-80.7885	62.1203	-164.864	-183.5322	73	12	10	7584	3	34	36
F-K	-31.0588	-12.0908	-144.669	-187.8186	74	14	8	6777	2	20	18
F-L	-26.7253	57.0575	-155.363	-125.0308	70	19	1	6990	0	15	20
G-J	-57.4781	-20.5831	-160.632	-238.6933	72	16	9	7315	2	16	18
G-K	0.0	39.8117	-166.246	-126.4343	74	21	2	7855	0	16	24
H-I	-63.309	95.1056	-162.772	-130.9753	71	12	9	7653	2	31	37
H-J	0.0	15.0883	-0.0981	14.9902	3	0	0	11	0	1	8
H-M	0.0	0.0	-0.0093	-0.0093	2	0	0	2	0	0	6
H-N	-54.57	12.0538	-141.837	-184.3532	71	6	9	6914	2	33	35
I-J	-56.672	106.932	-186.431	-136.171	73	14	10	7734	2	35	36
I-K	0.0	0.0	-0.0258	-0.0258	2	0	0	4	0	0	7
I-M	0.0	0.0	-0.0084	-0.0084	2	0	0	1	0	0	2
I-N	0.0	0.0	-0.0015	-0.0015	2	0	0	1	0	0	5
J-K	-53.0224	45.8704	-154.768	-161.9201	68	8	9	6950	3	31	35
J-L	0.0	0.0	-0.2518	-0.2518	3	0	0	18	0	0	7
J-M	0.0	0.0	-0.0092	-0.0092	2	0	0	1	0	0	1
K-L	-73.9658	33.2271	-190.439	-231.1777	71	15	10	8319	3	36	39
K-M	0.0	0.0	-0.0877	-0.0877	2	0	0	9	0	1	6
L-M	-60.571	53.7127	-148.751	-155.6093	68	19	9	7006	5	32	33
M-N	-59.1934	71.636	-164.637	-152.1944	72	11	10	7710	3	36	34

Interface residues

• A-B: ALA1A, ALA44A, ALA63B, ALA90B, ALA95B, ARG49A, ARG49B, ARG57A, ARG57B, ARG91B, ASN4A, ASP10A, ASP10B, ASP51A, ASP51B, ASP53A, ASP53B, ASP61B, ASP66B, ASP92B, GLN38B, GLU35B, GLU39B, GLU52A, GLU52B, GLU55A, GLU55B, GLU77A, GLU9A, GLY46A, GLY48A, GLY54A, GLY74A, GLY75A, ILE12A, ILE12B, ILE58B, ILE5A, ILE69B, ILE78A, ILE87A, LEU13A, LEU60B, LEU88A, LEU8A, LEU94B, LYS11A, LYS2A, LYS34A, LYS36B, LYS56A, LYS56B, LYS6A, LYS99B, PRO37B, PRO47A, PRO59B, PRO7A, SER71B, SER89A, SER98B, THR67B, THR76A, TRP50A, TRP50B, TYR70B, TYR73A, VAL3A, VAL42B, VAL62B, VAL68B, VAL93B, VAL96B, VAL97B
• A-C: ASP53A, GLU52A, GLU52C
• A-F: GLU52A, GLU52F
• A-G: ALA1G, ALA44G, ALA63A, ALA90A, ALA95A, ARG49G, ARG57A, ARG57G, ARG91A, ASN4G, ASP51A, ASP51G, ASP53A, ASP53G, ASP61A, ASP66A, ASP92A, GLN38A, GLU35A, GLU39A, GLU52A, GLU52G, GLU55A, GLU55G, GLU77G, GLU9G, GLY46G, GLY48G, GLY54G, GLY74G, GLY75G, ILE12A, ILE12G, ILE58A, ILE5G, ILE69A, ILE78G, ILE87G, LEU13G, LEU60A, LEU88G, LEU8G, LEU94A, LYS11G, LYS2G, LYS34G, LYS36A, LYS56A, LYS56G, LYS6G, LYS99A, PRO37A, PRO47G, PRO59A, PRO7G, SER71A, SER89G, SER98A, THR67A, THR76G, TRP50G, TYR70A, TYR80G, VAL3G, VAL42A, VAL62A, VAL68A, VAL93A, VAL96A, VAL97A
• A-I: ALA24A, ALA24I, ALA33A, ALA33I, ASN4A, ASN4I, ASN81A, ASN81I, ASP31A, ASP31I, GLU18I, GLU20A, GLU20I, GLU77A, GLU77I, GLU83A, GLU83I, GLU84A, GLU84I, GLY26A, GLY26I, GLY74A, GLY74I, GLY75A, GLY75I, GLY82A, GLY82I, ILE29A, ILE29I, ILE5A, ILE5I, ILE78A, ILE78I, ILE87A, ILE87I, LEU13A, LEU13I, LEU27A, LEU27I, LEU86A, LEU86I, LYS2A, LYS2I, LYS34A, LYS34I, LYS6A, LYS72A, LYS72I, LYS79A, LYS79I, PRO30A, PRO30I, SER25A, SER25I, THR21A, THR21I, THR22A, THR22I, THR23A, THR23I, THR32A, THR32I, THR76A, THR76I, TYR73I, TYR80A, TYR80I, TYR85A, TYR85I, VAL28A, VAL28I, VAL3A, VAL3I
• A-J: ALA19A, ALA19J, ALA24A, ALA24J, ALA33A, ALA33J, ALA95A, ALA95J, ASN17A, ASN17J, ASP31A, ASP31J, GLN38A, GLN38J, GLU18A, GLU18J, GLU20A, GLU20J, GLU35A, GLU35J, GLU39A, GLU39J, GLY26A, GLY26J, GLY40A, GLY40J, ILE29A, ILE29J, ILE69A, ILE69J, LEU27A, LEU27J, LEU94A, LEU94J, LYS34A, LYS34J, LYS36A, LYS36J, LYS72A, LYS72J, LYS99A, LYS99J, PRO30A, PRO30J, PRO37A, PRO37J, SER25A, SER25J, SER71A, SER98A, SER98J, THR21A, THR21J, THR22A, THR22J, THR23A, THR23J, THR32A, THR32J, THR41A, THR67A, THR67J, TYR70A, TYR70J, TYR73J, VAL28A, VAL28J, VAL68A, VAL68J, VAL96A, VAL97A, VAL97J
• B-C: ALA44B, ALA63C, ALA90C, ALA95C, ARG49B, ARG49C, ARG57B, ARG57C, ARG91C, ASN4B, ASP10B, ASP10C, ASP51B, ASP51C, ASP53B, ASP53C, ASP61C, ASP66C, ASP92C, GLN38C, GLU35C, GLU39C, GLU52B, GLU52C, GLU55B, GLU55C, GLU77B, GLU9B, GLY46B, GLY48B, GLY54B, GLY54C, GLY74B, GLY75B, ILE12B, ILE12C, ILE58C, ILE5B, ILE69C, ILE78B, ILE87B, LEU13B, LEU60C, LEU86B, LEU88B, LEU8B, LEU94C, LYS11B, LYS2B, LYS36C, LYS56C, LYS6B, LYS99C, PRO37C, PRO47B, PRO59C, PRO7B, SER71C, SER89B, SER98C, THR67C, THR76B, TRP50B, TRP50C, TYR70C, TYR80B, VAL3B, VAL42C, VAL62C, VAL68C, VAL93C, VAL96C, VAL97C
• B-D: GLU52B, GLU52D
• B-G: GLU52B, GLU52G
• B-H: ALA19B, ALA1H, ALA24B, ALA24H, ALA33H, ASN4B, ASN4H, ASN81B, ASN81H, ASP31B, ASP31H, GLU20B, GLU20H, GLU77B, GLU77H, GLU83B, GLU83H, GLU84B, GLU84H, GLY26B, GLY26H, GLY74B, GLY75B, GLY75H, GLY82B, GLY82H, ILE29B, ILE29H, ILE5B, ILE5H, ILE78B, ILE78H, ILE87B, ILE87H, LEU13H, LEU27B, LEU27H, LEU86B, LEU86H, LYS2B, LYS2H, LYS34B, LYS34H, LYS6H, LYS72B, LYS79B, LYS79H, PRO30B, PRO30H, SER25B, SER25H, THR21B, THR22B, THR22H, THR23B, THR23H, THR32B, THR32H, THR76B, THR76H, TYR73B, TYR80B, TYR80H, TYR85B, TYR85H, VAL28B, VAL28H, VAL3B, VAL3H
• B-I: ALA19B, ALA19I, ALA24B, ALA24I, ALA33B, ALA33I, ALA95B, ALA95I, ASN17B, ASN17I, ASP31B, ASP31I, GLN38B, GLN38I, GLU18B, GLU18I, GLU20B, GLU20I, GLU35B, GLU35I, GLU39B, GLU39I, GLY26B, GLY26I, GLY40B, GLY40I, ILE29B, ILE29I, ILE69B, ILE69I, LEU27B, LEU27I, LEU94B, LEU94I, LYS34B, LYS34I, LYS36B, LYS36I, LYS72B, LYS72I, LYS99B, LYS99I, PRO30B, PRO30I, PRO37B, PRO37I, SER25B, SER25I, SER71I, SER98B, SER98I, THR21B, THR21I, THR22B, THR22I, THR23B, THR23I, THR32B, THR32I, THR41B, THR67B, THR67I, TYR70B, TYR70I, TYR73B, VAL28B, VAL28I, VAL68B, VAL68I, VAL96B, VAL96I, VAL97B, VAL97I
• C-D: ALA44C, ALA63D, ALA90D, ALA95D, ARG49C, ARG49D, ARG57C, ARG57D, ARG91D, ASN4C, ASP51C, ASP51D, ASP53C, ASP53D, ASP61D, ASP66D, ASP92D, GLN38D, GLU35D, GLU39D, GLU52C, GLU52D, GLU55C, GLU55D, GLU77C, GLU9C, GLY46C, GLY48C, GLY54C, GLY74C, GLY75C, ILE12C, ILE12D, ILE58D, ILE5C, ILE69D, ILE78C, ILE87C, LEU13C, LEU60D, LEU88C, LEU8C, LEU94D, LYS11C, LYS2C, LYS36D, LYS56D, LYS6C, LYS99D, PRO37D, PRO47C, PRO59D, PRO7C, SER71D, SER89C, SER98D, THR67D, THR76C, TRP50C, TYR70D, TYR80C, VAL3C, VAL42D, VAL62D, VAL68D, VAL93D, VAL96D, VAL97D
• C-H: ALA19C, ALA19H, ALA24C, ALA24H, ALA33C, ALA33H, ALA95H, ASN17C, ASN17H, ASP31C, ASP31H, GLN38C, GLN38H, GLU18C, GLU18H, GLU20C, GLU20H, GLU35C, GLU35H, GLU39C, GLU39H, GLY26C, GLY26H, GLY40C, GLY40H, ILE29C, ILE29H, ILE69C, ILE69H, LEU27C, LEU27H, LEU94C, LEU94H, LYS34C, LYS34H, LYS36C, LYS36H, LYS72C, LYS72H, LYS99C, LYS99H, PRO30C, PRO30H, PRO37C, PRO37H, SER25C, SER25H, SER71H, SER98C, SER98H, THR21C, THR21H, THR22C, THR22H, THR23C, THR23H, THR32C, THR32H, THR41C, THR41H, THR67C, THR67H, TYR70C, TYR70H, TYR73H, VAL28C, VAL28H, VAL68C, VAL68H, VAL96H, VAL97C, VAL97H
• C-N: ALA1N, ALA24C, ALA24N, ALA33C, ALA33N, ASN4C, ASN4N, ASN81C, ASN81N, ASP31C, ASP31N, GLU20C, GLU20N, GLU77C, GLU77N, GLU83C, GLU83N, GLU84C, GLU84N, GLY26C, GLY26N, GLY74C, GLY74N, GLY75C, GLY75N, GLY82C, GLY82N, ILE29C, ILE29N, ILE5C, ILE5N, ILE78C, ILE78N, ILE87C, ILE87N, LEU13C, LEU13N, LEU27C, LEU27N, LEU86C, LEU86N, LYS2C, LYS2N, LYS34C, LYS34N, LYS6C, LYS6N, LYS72C, LYS72N, LYS79C, LYS79N, PRO30C, PRO30N, SER25C, SER25N, THR21C, THR21N, THR22C, THR22N, THR23C, THR23N, THR32C, THR32N, THR76C, THR76N, TYR73C, TYR73N, TYR80C, TYR80N, TYR85C, TYR85N, VAL28C, VAL28N, VAL3C, VAL3N
• D-E: ALA1D, ALA44D, ALA63E, ALA90E, ALA95E, ARG49D, ARG49E, ARG57D, ARG57E, ARG91E, ASN4D, ASP10D, ASP51D, ASP51E, ASP53D, ASP53E, ASP61E, ASP66E, ASP92E, GLN38E, GLU35E, GLU39E, GLU52D, GLU52E, GLU55D, GLU77D, GLU9D, GLY46D, GLY48D, GLY54D, GLY54E, GLY74D, GLY75D, ILE12D, ILE12E, ILE58E, ILE5D, ILE69E, ILE78D, ILE87D, LEU13D, LEU60E, LEU88D, LEU8D, LEU94E, LYS11D, LYS2D, LYS34D, LYS36E, LYS56D, LYS56E, LYS6D, LYS99E, PRO37E, PRO47D, PRO59E, PRO7D, SER71E, SER89D, SER98E, THR67E, THR76D, TRP50D, TRP50E, TYR70E, VAL3D, VAL42E, VAL62E, VAL68E, VAL93E, VAL96E, VAL97E
• D-F: GLU52D, GLU52F
• D-M: ALA1M, ALA24D, ALA24M, ALA33D, ALA33M, ASN4D, ASN4M, ASN81D, ASN81M, ASP31D, ASP31M, GLU18M, GLU20D, GLU20M, GLU77D, GLU77M, GLU83D, GLU83M, GLU84D, GLU84M, GLY26D, GLY26M, GLY74D, GLY74M, GLY75D, GLY75M, GLY82D, GLY82M, ILE29D, ILE29M, ILE5D, ILE5M, ILE78D, ILE78M, ILE87D, ILE87M, LEU13D, LEU13M, LEU27D, LEU27M, LEU86D, LEU86M, LYS2D, LYS2M, LYS34D, LYS34M, LYS6D, LYS72D, LYS72M, LYS79D, LYS79M, PRO30D, PRO30M, SER25D, SER25M, THR21D, THR21M, THR22D, THR22M, THR23D, THR23M, THR32D, THR32M, THR76D, THR76M, TYR73M, TYR80D, TYR80M, TYR85D, TYR85M, VAL28D, VAL28M, VAL3D, VAL3M
• D-N: ALA19D, ALA19N, ALA24D, ALA24N, ALA33D, ALA33N, ALA95D, ALA95N, ASN17D, ASN17N, ASP31D, ASP31N, GLN38D, GLN38N, GLU18D, GLU18N, GLU20D, GLU20N, GLU35D, GLU35N, GLU39D, GLU39N, GLY26D, GLY26N, GLY40D, GLY40N, ILE29D, ILE29N, ILE69D, ILE69N, LEU27D, LEU27N, LEU94D, LEU94N, LYS34D, LYS34N, LYS36D, LYS36N, LYS72D, LYS72N, LYS99D, LYS99N, PRO30D, PRO30N, PRO37D, PRO37N, SER25D, SER25N, SER71D, SER71N, SER98D, SER98N, THR21D, THR21N, THR22D, THR22N, THR23D, THR23N, THR32D, THR32N, THR41D, THR41N, THR67D, THR67N, TYR70D, TYR70N, TYR73D, TYR73N, VAL28D, VAL28N, VAL68D, VAL68N, VAL96D, VAL96N, VAL97D, VAL97N
• E-F: ALA44E, ALA63F, ALA90F, ALA95F, ARG49E, ARG49F, ARG57E, ARG57F, ARG91E, ARG91F, ASN4E, ASP51E, ASP51F, ASP53E, ASP53F, ASP61F, ASP66F, ASP92F, GLN38F, GLU35F, GLU39F, GLU52E, GLU52F, GLU55E, GLU55F, GLU77E, GLU9E, GLY46E, GLY48E, GLY54E, GLY54F, GLY74E, GLY75E, ILE12E, ILE12F, ILE58F, ILE5E, ILE69F, ILE78E, ILE87E, LEU13E, LEU60F, LEU88E, LEU8E, LEU94F, LYS11E, LYS2E, LYS36F, LYS56E, LYS56F, LYS6E, LYS99F, PRO37F, PRO47E, PRO59F, PRO7E, SER71F, SER89E, SER98F, THR67F, THR76E, TRP50E, TRP50F, TYR70F, TYR80E, VAL3E, VAL42F, VAL62F, VAL68F, VAL93F, VAL96F, VAL97F
• E-G: ASP53E, GLU52E, GLU52G
• E-L: ALA24E, ALA24L, ALA33E, ALA33L, ASN4E, ASN4L, ASN81E, ASN81L, ASP31E, ASP31L, GLU18L, GLU20E, GLU20L, GLU77E, GLU77L, GLU83E, GLU83L, GLU84E, GLU84L, GLY26E, GLY26L, GLY74E, GLY75E, GLY75L, GLY82E, GLY82L, ILE29E, ILE29L, ILE5E, ILE5L, ILE78E, ILE78L, ILE87E, ILE87L, LEU13E, LEU13L, LEU27E, LEU27L, LEU86E, LEU86L, LYS2E, LYS2L, LYS34E, LYS34L, LYS6E, LYS6L, LYS72E, LYS72L, LYS79E, LYS79L, PRO30E, PRO30L, SER25E, SER25L, THR21E, THR21L, THR22E, THR22L, THR23E, THR23L, THR32E, THR32L, THR76E, THR76L, TYR73E, TYR80E, TYR80L, TYR85E, TYR85L, VAL28E, VAL28L, VAL3E, VAL3L
• E-M: ALA19E, ALA19M, ALA24E, ALA24M, ALA33E, ALA33M, ALA95E, ALA95M, ASN17E, ASN17M, ASP31E, ASP31M, GLN38E, GLN38M, GLU18E, GLU18M, GLU20E, GLU20M, GLU35E, GLU35M, GLU39E, GLU39M, GLY26E, GLY26M, GLY40E, GLY40M, ILE29E, ILE29M, ILE69E, ILE69M, LEU27E, LEU27M, LEU94E, LEU94M, LYS34E, LYS34M, LYS36E, LYS36M, LYS72E, LYS72M, LYS99E, LYS99M, PRO30E, PRO30M, PRO37E, PRO37M, SER25E, SER25M, SER71M, SER98E, SER98M, THR21E, THR21M, THR22E, THR22M, THR23E, THR23M, THR32E, THR32M, THR41M, THR67E, THR67M, TYR70E, TYR70M, VAL28E, VAL28M, VAL68E, VAL68M, VAL96E, VAL97E, VAL97M
• F-G: ALA1F, ALA44F, ALA63G, ALA90G, ALA95G, ARG49F, ARG49G, ARG57F, ARG57G, ARG91G, ASN4F, ASP10F, ASP10G, ASP51F, ASP51G, ASP53F, ASP53G, ASP61G, ASP66G, ASP92G, GLN38G, GLU35G, GLU39G, GLU52F, GLU52G, GLU55F, GLU55G, GLU77F, GLU9F, GLY46F, GLY48F, GLY54F, GLY74F, GLY75F, ILE12F, ILE12G, ILE58G, ILE5F, ILE69G, ILE78F, ILE87F, LEU13F, LEU60G, LEU88F, LEU8F, LEU94G, LYS11F, LYS2F, LYS34F, LYS36G, LYS56G, LYS6F, LYS99G, PRO37G, PRO47F, PRO59G, PRO7F, SER71G, SER89F, SER98G, THR67G, THR76F, TRP50F, TRP50G, TYR70G, TYR80F, VAL3F, VAL42G, VAL62G, VAL68G, VAL93G, VAL96G, VAL97G
• F-K: ALA1F, ALA24F, ALA24K, ALA33F, ALA33K, ASN4F, ASN4K, ASN81F, ASN81K, ASP31F, ASP31K, GLU20F, GLU20K, GLU77F, GLU77K, GLU83F, GLU83K, GLU84F, GLU84K, GLY26F, GLY26K, GLY74F, GLY74K, GLY75F, GLY75K, GLY82F, GLY82K, ILE29F, ILE29K, ILE5F, ILE5K, ILE78F, ILE78K, ILE87F, ILE87K, LEU13F, LEU13K, LEU27F, LEU27K, LEU86F, LEU86K, LYS2F, LYS2K, LYS34F, LYS34K, LYS6F, LYS6K, LYS72F, LYS72K, LYS79F, LYS79K, PRO30F, PRO30K, SER25F, SER25K, THR21F, THR22F, THR22K, THR23F, THR23K, THR32F, THR32K, THR76F, THR76K, TYR73F, TYR73K, TYR80F, TYR80K, TYR85F, TYR85K, VAL28F, VAL28K, VAL3F, VAL3K
• F-L: ALA19F, ALA19L, ALA24F, ALA24L, ALA33F, ALA33L, ALA95F, ALA95L, ASN17F, ASN17L, ASP31F, ASP31L, GLN38F, GLN38L, GLU18F, GLU18L, GLU20F, GLU20L, GLU35F, GLU35L, GLU39F, GLU39L, GLY26F, GLY26L, GLY40F, GLY40L, ILE29F, ILE29L, ILE69F, ILE69L, LEU27F, LEU27L, LEU94F, LEU94L, LYS34F, LYS34L, LYS36F, LYS36L, LYS72L, LYS99F, LYS99L, PRO30F, PRO30L, PRO37F, PRO37L, SER25F, SER25L, SER71F, SER98F, SER98L, THR21F, THR21L, THR22F, THR22L, THR23F, THR23L, THR32F, THR32L, THR41L, THR67F, THR67L, TYR70F, TYR70L, TYR73F, VAL28F, VAL28L, VAL68F, VAL68L, VAL97F, VAL97L
• G-J: ALA24G, ALA24J, ALA33G, ALA33J, ASN4G, ASN4J, ASN81G, ASN81J, ASP31G, ASP31J, GLU20G, GLU20J, GLU77G, GLU77J, GLU83G, GLU83J, GLU84G, GLU84J, GLY26G, GLY26J, GLY74G, GLY74J, GLY75G, GLY75J, GLY82G, GLY82J, ILE29G, ILE29J, ILE5G, ILE5J, ILE78G, ILE78J, ILE87G, ILE87J, LEU13G, LEU13J, LEU27G, LEU27J, LEU86G, LEU86J, LYS2G, LYS2J, LYS34G, LYS34J, LYS6G, LYS72G, LYS72J, LYS79G, LYS79J, PRO30G, PRO30J, SER25G, SER25J, THR21G, THR21J, THR22J, THR23G, THR23J, THR32G, THR32J, THR76G, THR76J, TYR73G, TYR73J, TYR80G, TYR80J, TYR85G, TYR85J, VAL28G, VAL28J, VAL3G, VAL3J
• G-K: ALA16K, ALA19G, ALA19K, ALA24G, ALA24K, ALA33G, ALA33K, ALA95G, ALA95K, ASN17G, ASN17K, ASP31G, ASP31K, GLN38G, GLN38K, GLU18G, GLU18K, GLU20G, GLU20K, GLU35G, GLU35K, GLU39G, GLU39K, GLY26G, GLY26K, GLY40G, GLY40K, ILE29G, ILE29K, ILE69G, ILE69K, LEU27G, LEU27K, LEU94G, LEU94K, LYS34G, LYS34K, LYS36G, LYS36K, LYS72G, LYS72K, LYS99G, LYS99K, PRO30G, PRO30K, PRO37G, PRO37K, SER25G, SER25K, SER71K, SER98G, SER98K, THR21G, THR21K, THR22G, THR22K, THR23G, THR23K, THR32G, THR32K, THR41K, THR67G, THR67K, TYR70G, TYR70K, TYR73K, VAL28G, VAL28K, VAL68G, VAL68K, VAL96G, VAL96K, VAL97G, VAL97K
• H-I: ALA1H, ALA44H, ALA63I, ALA90I, ALA95I, ARG49H, ARG49I, ARG57H, ARG57I, ARG91I, ASN4H, ASP51H, ASP51I, ASP53H, ASP53I, ASP61I, ASP66I, ASP92I, GLN38I, GLU35I, GLU39I, GLU52H, GLU52I, GLU55H, GLU55I, GLU77H, GLU9H, GLY46H, GLY48H, GLY54H, GLY54I, GLY74H, GLY75H, ILE12H, ILE12I, ILE58I, ILE5H, ILE69I, ILE78H, ILE87H, LEU13H, LEU60I, LEU88H, LEU8H, LEU94I, LYS11H, LYS2H, LYS36I, LYS56H, LYS56I, LYS6H, LYS99I, PRO37I, PRO47H, PRO59I, PRO7H, SER71I, SER89H, SER98I, THR67I, THR76H, TRP50H, TRP50I, TYR70I, VAL3H, VAL42I, VAL62I, VAL68I, VAL93I, VAL96I, VAL97I
• H-J: ASP53H, GLU52H, GLU52J
• H-M: GLU52H, GLU52M
• H-N: ALA1N, ALA44N, ALA63H, ALA90H, ALA95H, ARG49H, ARG49N, ARG57H, ARG57N, ARG91H, ASN4N, ASP51H, ASP51N, ASP53H, ASP53N, ASP61H, ASP66H, ASP92H, GLN38H, GLU35H, GLU39H, GLU52H, GLU52N, GLU55H, GLU55N, GLU77N, GLU9N, GLY46N, GLY48N, GLY54N, GLY74N, GLY75N, ILE12H, ILE12N, ILE58H, ILE5N, ILE69H, ILE78N, ILE87N, LEU13N, LEU60H, LEU88N, LEU8N, LEU94H, LYS11N, LYS2N, LYS34N, LYS36H, LYS56H, LYS56N, LYS6N, LYS99H, PRO37H, PRO47N, PRO59H, PRO7N, SER71H, SER89N, SER98H, THR67H, THR76N, TRP50N, TYR70H, TYR80N, VAL3N, VAL42H, VAL62H, VAL68H, VAL93H, VAL96H, VAL97H
• I-J: ALA44I, ALA63J, ALA90J, ALA95J, ARG49I, ARG49J, ARG57I, ARG57J, ARG91J, ASN4I, ASP51I, ASP51J, ASP53I, ASP53J, ASP61J, ASP66J, ASP92J, GLN38J, GLU35J, GLU39J, GLU52I, GLU52J, GLU55I, GLU55J, GLU77I, GLU9I, GLY46I, GLY48I, GLY54I, GLY54J, GLY74I, GLY75I, ILE12I, ILE12J, ILE58J, ILE5I, ILE69J, ILE78I, ILE87I, LEU13I, LEU60J, LEU86I, LEU88I, LEU8I, LEU94J, LYS11I, LYS2I, LYS34I, LYS36J, LYS56I, LYS56J, LYS6I, LYS99J, PRO37J, PRO47I, PRO59J, PRO7I, SER71J, SER89I, SER98J, THR67J, THR76I, TRP50I, TRP50J, TYR70J, TYR80I, VAL3I, VAL42J, VAL62J, VAL68J, VAL93J, VAL96J, VAL97J
• I-K: GLU52I, GLU52K
• I-M: GLU52I, GLU52M
• I-N: GLU52I, GLU52N
• J-K: ALA44J, ALA63K, ALA90K, ALA95K, ARG49J, ARG49K, ARG57J, ARG57K, ARG91K, ASN4J, ASP51J, ASP51K, ASP53J, ASP53K, ASP61K, ASP66K, ASP92K, GLN38K, GLU35K, GLU39K, GLU52J, GLU52K, GLU55J, GLU55K, GLU77J, GLU9J, GLY46J, GLY48J, GLY54J, GLY74J, GLY75J, ILE12J, ILE12K, ILE58K, ILE5J, ILE69K, ILE78J, ILE87J, LEU13J, LEU60K, LEU88J, LEU8J, LEU94K, LYS11J, LYS2J, LYS36K, LYS56K, LYS6J, LYS99K, PRO37K, PRO47J, PRO59K, PRO7J, SER71K, SER89J, SER98K, THR67K, THR76J, TRP50J, TYR70K, TYR80J, VAL3J, VAL42K, VAL62K, VAL68K, VAL93K, VAL96K, VAL97K
• J-L: ASP53J, GLU52J, GLU52L
• J-M: GLU52J, GLU52M
• K-L: ALA44K, ALA63L, ALA90L, ALA95L, ARG49K, ARG49L, ARG57K, ARG57L, ARG91L, ASN4K, ASP10K, ASP51K, ASP51L, ASP53K, ASP53L, ASP61L, ASP66L, ASP92L, GLN38L, GLU35L, GLU39L, GLU52K, GLU52L, GLU55K, GLU55L, GLU77K, GLU9K, GLY46K, GLY48K, GLY54K, GLY54L, GLY74K, GLY75K, ILE12K, ILE12L, ILE58L, ILE5K, ILE69L, ILE78K, ILE87K, LEU13K, LEU60L, LEU88K, LEU8K, LEU94L, LYS11K, LYS2K, LYS36L, LYS56K, LYS56L, LYS6K, LYS99L, PRO37L, PRO47K, PRO59L, PRO7K, SER71L, SER89K, SER98L, THR67L, THR76K, TRP50K, TRP50L, TYR70L, VAL3K, VAL42L, VAL62L, VAL68L, VAL93L, VAL96L, VAL97L
• K-M: GLU52K, GLU52M
• L-M: ALA44L, ALA63M, ALA90M, ALA95M, ARG49L, ARG57L, ARG57M, ARG91M, ASN4L, ASP51L, ASP51M, ASP53L, ASP53M, ASP61M, ASP66M, ASP92M, GLN38M, GLU35M, GLU39M, GLU52L, GLU52M, GLU55L, GLU55M, GLU77L, GLU9L, GLY46L, GLY48L, GLY54L, GLY54M, GLY74L, GLY75L, ILE12L, ILE12M, ILE58M, ILE5L, ILE69M, ILE78L, ILE87L, LEU13L, LEU60M, LEU88L, LEU8L, LEU94M, LYS11L, LYS2L, LYS36M, LYS56L, LYS56M, LYS6L, LYS99M, PRO37M, PRO47L, PRO59M, PRO7L, SER71M, SER89L, SER98M, THR67M, THR76L, TRP50L, TYR70M, VAL3L, VAL42M, VAL62M, VAL68M, VAL93M, VAL96M, VAL97M
• M-N: ALA1M, ALA44M, ALA63N, ALA90N, ALA95N, ARG49M, ARG49N, ARG57M, ARG57N, ARG91N, ASN4M, ASP10M, ASP51M, ASP51N, ASP53M, ASP53N, ASP61N, ASP66N, ASP92N, GLN38N, GLU35N, GLU39N, GLU52M, GLU52N, GLU55M, GLU55N, GLU77M, GLU9M, GLY46M, GLY48M, GLY54M, GLY54N, GLY74M, GLY75M, ILE12M, ILE12N, ILE58N, ILE5M, ILE69N, ILE78M, ILE87M, LEU13M, LEU60N, LEU88M, LEU8M, LEU94N, LYS11M, LYS2M, LYS36N, LYS56M, LYS56N, LYS6M, LYS99N, PRO37N, PRO47M, PRO59N, PRO7M, SER71N, SER89M, SER98N, THR67N, THR76M, TRP50M, TRP50N, TYR70N, VAL3M, VAL42N, VAL62N, VAL68N, VAL93N, VAL96N, VAL97N