1OY0

the crystal structure of the first enzyme of pantothenate biosynthetic pathway, ketopantoate hydroxymethyltransferase from mycobacterium tuberculosis shows a decameric assembly and terminal helix-swapping

• Total interactions analyzed: 10
• Total true interactions: 5
• Strongest Interaction:
  • Chains: A-C
  • Int. Res.: 59
  • Norm. En. per Res.: -2.4048
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-38.069	0.0	-81.1171	-119.1861	55	3	2	3607	0	13	3
A-C	-41.9864	0.0	-99.8948	-141.8812	59	4	2	3978	0	13	3
B-D	-39.2503	0.0	-89.1076	-128.3579	55	5	2	3779	0	13	3
C-E	-38.2338	0.0	-89.8833	-128.1171	58	5	2	3872	0	13	3
D-E	-38.146	0.0	-79.1337	-117.2797	56	4	2	3551	0	13	3

Interface residues

• A-B: ALA109B, ALA113A, ALA113B, ALA116A, ALA118A, ALA127A, ALA143A, ALA147A, ALA148A, ALA65B, ARG120A, ARG137B, ARG22A, ASP124A, ASP62B, ASP72B, ASP80B, CYS144A, GLN141B, GLU108B, GLU81B, GLY105B, GLY110B, GLY126A, GLY134B, GLY135B, GLY149A, HIS128A, ILE150A, ILE77B, ILE79B, LEU115A, LEU122A, LEU145A, LEU82B, LYS123A, LYS20A, PHE104B, PHE121A, PRO103B, PRO111A, PRO151A, PRO76B, SER106B, SER78B, THR112A, THR112B, THR119A, THR146A, THR73B, THR74B, TYR107B, TYR71B, VAL138B, VAL75B
• A-C: ALA109A, ALA113A, ALA113C, ALA116C, ALA118C, ALA127C, ALA143C, ALA147C, ALA148C, ALA65A, ARG120C, ARG137A, ARG22C, ASP124C, ASP62A, ASP72A, ASP80A, CYS144C, GLN141A, GLU108A, GLU133A, GLU81A, GLY105A, GLY110A, GLY125C, GLY126C, GLY134A, GLY135A, GLY149C, HIS128C, ILE150C, ILE77A, ILE79A, LEU102A, LEU115C, LEU122C, LEU145C, LEU82A, LYS123C, LYS20C, PHE104A, PHE121C, PRO103A, PRO111C, PRO151C, PRO76A, SER106A, SER78A, THR112A, THR112C, THR119C, THR146C, THR73A, THR74A, TYR107A, TYR71A, VAL138A, VAL75A, VAL90C
• B-D: ALA109D, ALA113B, ALA113D, ALA116B, ALA118B, ALA127B, ALA143B, ALA147B, ALA148B, ALA65D, ARG120B, ARG137D, ARG22B, ASP124B, ASP62D, ASP72D, ASP80D, CYS144B, GLN141D, GLU108D, GLU81D, GLY105D, GLY110D, GLY126B, GLY134D, GLY135D, GLY149B, HIS128B, ILE150B, ILE77D, ILE79D, LEU115B, LEU122B, LEU145B, LEU82D, LYS123B, LYS20B, PHE104D, PHE121B, PRO103D, PRO111B, PRO151B, PRO76D, SER106D, SER78D, THR112B, THR112D, THR119B, THR146B, THR73D, THR74D, TYR107D, TYR71D, VAL138D, VAL75D
• C-E: ALA109C, ALA113C, ALA113E, ALA116E, ALA118E, ALA127E, ALA143E, ALA147E, ALA148E, ALA65C, ARG120E, ARG137C, ARG22E, ASP124E, ASP62C, ASP72C, ASP80C, CYS144E, GLN141C, GLU108C, GLU81C, GLY105C, GLY110C, GLY125E, GLY126E, GLY134C, GLY135C, GLY149E, HIS128E, ILE150E, ILE77C, ILE79C, LEU102C, LEU115E, LEU122E, LEU145E, LEU82C, LYS123E, LYS20E, PHE104C, PHE121E, PRO103C, PRO111E, PRO151E, PRO76C, SER106C, SER78C, THR112C, THR112E, THR119E, THR146E, THR73C, THR74C, TYR107C, TYR71C, VAL138C, VAL75C, VAL90E
• D-E: ALA109E, ALA113E, ALA116D, ALA118D, ALA127D, ALA143D, ALA147D, ALA148D, ALA65E, ARG120D, ARG137E, ARG22D, ASP124D, ASP62E, ASP72E, ASP80E, CYS144D, GLN141E, GLU108E, GLU81E, GLY105E, GLY110E, GLY125D, GLY126D, GLY134E, GLY135E, GLY149D, HIS128D, ILE150D, ILE77E, ILE79E, LEU115D, LEU122D, LEU145D, LEU82E, LYS123D, LYS20D, PHE104E, PHE121D, PRO103E, PRO111D, PRO151D, PRO76E, SER106E, SER78E, THR112D, THR112E, THR119D, THR146D, THR73E, THR74E, TYR107E, TYR71E, VAL138E, VAL75E, VAL90D