1OS9

binary enzyme-product complexes of human mmp12

• Total interactions analyzed: 15
• Total true interactions: 7
• Strongest Interaction:
  • Chains: B-D
  • Int. Res.: 70
  • Norm. En. per Res.: -3.2942
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-6.798	7.9561	-66.7126	-65.5544	71	0	0	3583	0	24	12
A-C	-67.4896	-1.7853	-153.153	-222.4279	70	11	0	5926	0	22	21
A-E	-69.2602	-3.1037	-134.235	-206.5989	71	10	0	5565	0	21	23
B-D	-66.5715	-0.9205	-163.101	-230.593	70	9	0	5979	0	22	21
B-F	-67.6721	-3.4971	-151.457	-222.6262	71	8	0	5582	0	21	20
C-E	0.0	8.307	-0.8918	7.4152	7	0	0	124	0	5	3
D-F	0.0	8.5483	-0.8569	7.6914	5	0	0	124	0	5	3

Interface residues

• A-B: ALA164A, ALA164B, ALA167A, ALA167B, ALA173A, ALA173B, ARG117A, ARG117B, ARG127A, ARG127B, ARG165A, ARG165B, ASN119A, ASN119B, ASN120A, ASN120B, ASN126A, ASN126B, ASN153A, ASN153B, ASP124A, ASP124B, ASP170A, ASP170B, ASP171A, ASP171B, ASP194A, ASP194B, GLU199A, GLU199B, GLY155A, GLY155B, GLY166A, GLY166B, GLY169A, GLY169B, GLY190A, GLY190B, HIS168A, HIS168B, HIS196A, HIS196B, ILE118A, ILE118B, ILE152A, ILE152B, ILE191A, ILE191B, LEU160A, LEU160B, LYS151A, LYS151B, MET125A, MET125B, MET156A, MET156B, PHE163A, PHE163B, PHE185A, PRO123A, PRO123B, THR122A, THR122B, THR154A, THR154B, TYR121A, TYR121B, VAL161A, VAL161B, VAL162A, VAL162B
• A-C: ALA173C, ALA182C, ALA184A, ALA184C, ALA216C, ALA234C, ARG110A, ASN211C, ASP171A, ASP171C, ASP175C, ASP198C, ASP200C, GLU201C, GLU219C, GLY106A, GLY176C, GLY178C, GLY179C, GLY186A, GLY209C, GLY221A, GLY225A, GLY227A, HIS172A, HIS172C, HIS183A, HIS183C, HIS196C, HIS218C, HIS222A, HIS222C, HIS228A, HIS228C, ILE180C, LEU181C, LEU214C, LEU224A, LEU226A, LEU261A, LYS177C, LYS241C, MET104A, MET105A, MET236A, MET236C, PHE174C, PHE185A, PHE197C, PHE202C, PHE237C, PHE248C, PRO107A, PRO187A, PRO238A, PRO238C, SER229A, SER230A, SER260A, THR210C, THR215C, THR239C, TRP203C, TYR240C, TYR242C, TYR262A, VAL108A, VAL217C, VAL235C, VAL243C
• A-E: ALA167A, ALA173A, ALA182A, ALA184A, ALA184E, ALA216A, ALA234A, ARG110E, ASN211A, ASP171E, ASP175A, ASP198A, ASP200A, GLU201A, GLU219A, GLY106E, GLY166A, GLY176A, GLY178A, GLY179A, GLY186E, GLY209A, GLY221E, GLY225E, GLY227E, HIS172E, HIS183A, HIS183E, HIS196A, HIS218A, HIS222A, HIS222E, HIS228A, HIS228E, ILE180A, LEU181A, LEU214A, LEU224E, LEU226E, LEU261E, LYS177A, LYS241A, MET104E, MET105E, MET236A, MET236E, PHE174A, PHE185E, PHE197A, PHE202A, PHE213A, PHE237A, PHE248A, PRO107E, PRO187E, PRO238A, PRO238E, SER229E, SER230E, SER260E, THR210A, THR215A, THR239A, TRP109E, TRP203A, TYR240A, TYR242A, TYR262E, VAL108E, VAL217A, VAL235A
• B-D: ALA173D, ALA182D, ALA184B, ALA184D, ALA216D, ALA234D, ARG110B, ARG256B, ASN211D, ASP171B, ASP175D, ASP198D, ASP200D, ASP253B, GLU201D, GLU219D, GLY106B, GLY166D, GLY176D, GLY178D, GLY179D, GLY186B, GLY209D, GLY221B, GLY225B, GLY227B, HIS172B, HIS183B, HIS183D, HIS196D, HIS218D, HIS222B, HIS222D, HIS228B, HIS228D, ILE180D, LEU181D, LEU214D, LEU224B, LEU226B, LEU261B, LYS177D, LYS241D, MET104B, MET105B, MET236B, MET236D, PHE174D, PHE185B, PHE197D, PHE202D, PHE237D, PHE248D, PRO107B, PRO187B, PRO238B, PRO238D, SER229B, SER230B, SER260B, THR210D, THR215D, THR239D, TRP203D, TYR240D, TYR242D, TYR262B, VAL108B, VAL217D, VAL235D
• B-F: ALA167B, ALA173B, ALA182B, ALA184B, ALA184F, ALA216B, ALA234B, ARG110F, ASN211B, ASP171B, ASP171F, ASP175B, ASP198B, ASP200B, GLU201B, GLU219B, GLY106F, GLY166B, GLY176B, GLY178B, GLY179B, GLY186F, GLY209B, GLY221F, GLY225F, GLY227F, HIS172B, HIS172F, HIS183B, HIS196B, HIS218B, HIS222B, HIS222F, HIS228B, HIS228F, ILE180B, LEU181B, LEU214B, LEU224F, LEU226F, LEU261F, LYS177B, LYS241B, MET104F, MET105F, MET236B, MET236F, PHE174B, PHE185F, PHE197B, PHE202B, PHE213B, PHE237B, PHE248B, PRO107F, PRO187F, PRO238B, PRO238F, SER229F, SER230F, SER260F, THR210B, THR215B, THR239B, TRP203B, TYR240B, TYR242B, TYR262F, VAL108F, VAL217B, VAL235B
• C-E: ALA167C, ARG165C, ARG256E, ASP200C, ASP264E, GLY166C, SER260E
• D-F: ARG165D, ARG256F, ASP200D, GLY166D, SER260F