1ORT

ornithine transcarbamoylase from pseudomonas aeruginosa

• Total interactions analyzed: 66
• Total true interactions: 30
• Strongest Interaction:
  • Chains: C-K
  • Int. Res.: 111
  • Norm. En. per Res.: -3.5359
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-D	-15.8974	-36.9607	-112.255	-165.1131	72	8	4	4763	0	16	27
A-E	-42.1984	-76.9187	-262.222	-381.3391	112	23	4	11626	11	46	58
A-I	-23.4578	23.2626	-143.383	-143.5782	94	11	2	6393	1	52	58
A-K	-26.1135	23.2626	-142.673	-145.5239	94	12	2	6383	1	52	58
A-L	-42.1984	-76.9187	-257.066	-376.1831	111	25	4	11672	11	46	58
B-E	-15.8974	-36.9607	-112.255	-165.1131	72	8	4	4763	0	16	27
B-F	-42.1984	-76.9187	-260.558	-379.6751	111	21	4	11571	11	46	58
B-G	-17.7666	23.2626	-142.486	-136.99	94	11	2	6372	1	52	58
B-J	-42.1984	-76.9187	-262.222	-381.3391	112	23	4	11626	11	46	58
B-L	-17.7666	23.2626	-143.426	-137.93	94	11	2	6381	1	52	58
C-D	-44.7143	-76.9187	-257.019	-378.652	112	24	4	11581	11	46	58
C-F	-15.8974	-36.9607	-112.255	-165.1131	72	8	4	4763	0	16	27
C-H	-17.7666	23.2626	-143.064	-137.568	94	11	2	6366	1	52	58
C-J	-23.4578	23.2626	-143.383	-143.5782	94	11	2	6393	1	52	58
C-K	-52.2855	-76.9187	-263.281	-392.4852	111	21	4	11690	11	46	58
D-E	-17.7666	23.2626	-142.486	-136.99	94	11	2	6372	1	52	58
D-F	-17.7666	23.2626	-142.327	-136.831	94	11	2	6361	1	52	58
D-K	-46.8168	-76.9187	-261.433	-385.1685	111	23	4	11632	11	46	58
E-F	-17.7666	23.2626	-143.426	-137.93	94	11	2	6381	1	52	58
E-L	-42.1984	-76.9187	-260.558	-379.6751	111	21	4	11571	11	46	58
F-J	-42.1984	-76.9187	-257.066	-376.1831	111	25	4	11672	11	46	58
G-H	-46.8168	-76.9187	-261.433	-385.1685	111	23	4	11632	11	46	58
G-I	-44.7143	-76.9187	-257.019	-378.652	112	24	4	11581	11	46	58
G-J	-15.8974	-36.9607	-112.255	-165.1131	72	8	4	4763	0	16	27
G-L	-17.7666	23.2626	-142.327	-136.831	94	11	2	6361	1	52	58
H-I	-52.2855	-76.9187	-263.281	-392.4852	111	21	4	11690	11	46	58
H-J	-26.1135	23.2626	-142.673	-145.5239	94	12	2	6383	1	52	58
H-K	-15.8974	-36.9607	-112.255	-165.1131	72	8	4	4763	0	16	27
I-K	-17.7666	23.2626	-143.064	-137.568	94	11	2	6366	1	52	58
I-L	-15.8974	-36.9607	-112.255	-165.1131	72	8	4	4763	0	16	27

Interface residues

• A-D: ALA103A, ALA103D, ALA121A, ALA121D, ALA1A, ALA1D, ALA333A, ALA333D, ARG18A, ARG18D, ARG45A, ARG45D, ARG7A, ARG7D, ARG95A, ARG95D, ARG99A, ARG99D, ASN3A, ASN3D, ASN47A, ASN47D, ASN6A, ASN6D, ASP102A, ASP102D, ASP334A, ASP334D, GLN40A, GLN40D, GLY122A, GLY122D, GLY98A, GLY98D, HIS42A, HIS42D, HIS5A, HIS5D, ILE104A, ILE104D, ILE335A, ILE335D, LEU332A, LEU332D, LEU43A, LEU43D, LEU97A, LEU97D, LYS44A, LYS44D, LYS46A, LYS46D, MET100A, MET100D, MET4A, MET4D, PHE120A, PHE120D, PHE2A, PHE2D, PRO124A, PRO124D, THR331A, THR331D, TYR101A, TYR101D, TYR22A, TYR22D, VAL123A, VAL123D, VAL96A, VAL96D
• A-E: ALA276E, ALA313E, ALA317E, ALA49A, ALA62E, ALA66E, ALA67E, ALA72A, ALA72E, ALA94A, ARG320E, ARG45A, ARG58E, ARG60A, ARG60E, ARG95A, ARG99A, ASN279E, ASN311E, ASN319E, ASN47A, ASN73A, ASN73E, ASN80A, ASN80E, ASP102A, ASP69E, ASP78A, ASP78E, ASP92A, CYS61E, GLN287E, GLN316E, GLN41E, GLN70E, GLN83A, GLU116A, GLU281E, GLU303E, GLU307E, GLU315E, GLU318E, GLU39E, GLU64E, GLU88A, GLY285E, GLY37E, GLY71E, GLY85A, GLY98A, HIS278E, HIS322E, HIS86A, ILE288E, ILE312E, ILE324E, ILE48A, ILE51A, ILE77A, ILE84A, LEU274E, LEU50A, LEU50E, LEU97A, LYS283E, LYS286E, LYS31E, LYS34E, LYS44A, LYS46A, LYS54E, LYS87A, LYS91A, MET100A, MET236E, MET321E, MET90A, PHE120A, PHE277E, PHE306E, PHE314E, PHE63E, PRO275E, PRO79A, PRO79E, SER235E, SER280E, SER308E, SER56E, SER81A, SER81E, SER82A, SER89A, THR282E, THR55E, THR57E, THR59E, THR75A, THR93A, TYR101A, TYR35E, TYR68A, TYR68E, TYR76A, TYR76E, VAL232E, VAL234E, VAL284E, VAL65E, VAL74A, VAL74E, VAL96A
• A-I: ALA1I, ALA205I, ALA210I, ALA268A, ALA326I, ALA333I, ALA33A, ALA33I, ARG146A, ARG146I, ARG18I, ARG21I, ARG267A, ARG28A, ARG28I, ARG32A, ARG32I, ASN265A, ASN311A, ASN3I, ASP150A, ASP150I, ASP155A, ASP155I, ASP226A, ASP25I, ASP29A, ASP29I, ASP334I, GLN40A, GLN40I, GLN41A, GLN41I, GLN70I, GLU147A, GLU206I, GLU207I, GLU315A, GLU318A, GLU39A, GLU39I, GLY180I, GLY209I, GLY37A, GLY37I, HIS148A, HIS154I, HIS322A, HIS42A, HIS42I, HIS5I, ILE156I, ILE312A, ILE335I, LEU153I, LEU179I, LEU26I, LEU30I, LYS151A, LYS151I, LYS178I, LYS211I, LYS269A, LYS31A, LYS31I, LYS325I, LYS34A, LYS34I, MET181I, MET321A, PHE204I, PHE227A, PHE2I, PHE314A, PRO152A, PRO152I, PRO266A, PRO309A, SER149A, SER16I, SER208I, SER27I, SER308A, SER330I, THR17I, THR36A, THR36I, THR38A, THR38I, TYR22I, TYR310A, TYR35A, VAL329I, VAL65A
• A-K: ALA1A, ALA205A, ALA210A, ALA268K, ALA326A, ALA333A, ALA33A, ALA33K, ARG146A, ARG146K, ARG18A, ARG21A, ARG267K, ARG28A, ARG28K, ARG32A, ARG32K, ASN265K, ASN311K, ASN3A, ASP150A, ASP150K, ASP155A, ASP155K, ASP226K, ASP25A, ASP29A, ASP29K, ASP334A, GLN40A, GLN40K, GLN41A, GLN41K, GLN70A, GLU147K, GLU206A, GLU207A, GLU315K, GLU318K, GLU39A, GLU39K, GLY180A, GLY209A, GLY37A, GLY37K, HIS148K, HIS154A, HIS322K, HIS42A, HIS42K, HIS5A, ILE156A, ILE312K, ILE335A, LEU153A, LEU179A, LEU26A, LEU30A, LYS151A, LYS151K, LYS178A, LYS211A, LYS269K, LYS31A, LYS31K, LYS325A, LYS34A, LYS34K, MET181A, MET321K, PHE204A, PHE227K, PHE2A, PHE314K, PRO152A, PRO152K, PRO266K, PRO309K, SER149K, SER16A, SER208A, SER27A, SER308K, SER330A, THR17A, THR36A, THR36K, THR38A, THR38K, TYR22A, TYR310K, TYR35K, VAL329A, VAL65K
• A-L: ALA276A, ALA313A, ALA317A, ALA49L, ALA62A, ALA66A, ALA67A, ALA72A, ALA72L, ALA94L, ARG320A, ARG45L, ARG58A, ARG60A, ARG60L, ARG95L, ARG99L, ASN279A, ASN311A, ASN319A, ASN47L, ASN73A, ASN73L, ASN80A, ASN80L, ASP102L, ASP69A, ASP78A, ASP78L, ASP92L, CYS61A, GLN287A, GLN316A, GLN41A, GLN70A, GLN83L, GLU116L, GLU281A, GLU303A, GLU307A, GLU315A, GLU318A, GLU39A, GLU64A, GLU88L, GLY285A, GLY37A, GLY71A, GLY85L, GLY98L, HIS278A, HIS322A, HIS86L, ILE288A, ILE312A, ILE324A, ILE48L, ILE51L, ILE77L, ILE84L, LEU274A, LEU50A, LEU50L, LEU97L, LYS283A, LYS286A, LYS31A, LYS34A, LYS44L, LYS46L, LYS54A, LYS87L, LYS91L, MET100L, MET236A, MET321A, MET90L, PHE120L, PHE277A, PHE306A, PHE314A, PHE63A, PRO275A, PRO79A, PRO79L, SER235A, SER280A, SER308A, SER56A, SER81L, SER82L, SER89L, THR282A, THR55A, THR57A, THR59A, THR75L, THR93L, TYR101L, TYR35A, TYR68A, TYR68L, TYR76A, TYR76L, VAL232A, VAL234A, VAL284A, VAL65A, VAL74A, VAL74L, VAL96L
• B-E: ALA103B, ALA103E, ALA121B, ALA121E, ALA1B, ALA1E, ALA333B, ALA333E, ARG18B, ARG18E, ARG45B, ARG45E, ARG7B, ARG7E, ARG95B, ARG95E, ARG99B, ARG99E, ASN3B, ASN3E, ASN47B, ASN47E, ASN6B, ASN6E, ASP102B, ASP102E, ASP334B, ASP334E, GLN40B, GLN40E, GLY122B, GLY122E, GLY98B, GLY98E, HIS42B, HIS42E, HIS5B, HIS5E, ILE104B, ILE104E, ILE335B, ILE335E, LEU332B, LEU332E, LEU43B, LEU43E, LEU97B, LEU97E, LYS44B, LYS44E, LYS46B, LYS46E, MET100B, MET100E, MET4B, MET4E, PHE120B, PHE120E, PHE2B, PHE2E, PRO124B, PRO124E, THR331B, THR331E, TYR101B, TYR101E, TYR22B, TYR22E, VAL123B, VAL123E, VAL96B, VAL96E
• B-F: ALA276F, ALA313F, ALA317F, ALA49B, ALA62F, ALA66F, ALA67F, ALA72B, ALA72F, ALA94B, ARG320F, ARG45B, ARG58F, ARG60B, ARG60F, ARG95B, ARG99B, ASN279F, ASN311F, ASN319F, ASN47B, ASN73B, ASN73F, ASN80B, ASN80F, ASP102B, ASP69F, ASP78B, ASP78F, ASP92B, CYS61F, GLN287F, GLN316F, GLN41F, GLN70F, GLN83B, GLU116B, GLU281F, GLU303F, GLU307F, GLU315F, GLU318F, GLU39F, GLU64F, GLU88B, GLY285F, GLY37F, GLY71F, GLY85B, GLY98B, HIS278F, HIS322F, HIS86B, ILE288F, ILE312F, ILE324F, ILE48B, ILE51B, ILE77B, ILE84B, LEU274F, LEU50B, LEU50F, LEU97B, LYS283F, LYS286F, LYS31F, LYS34F, LYS44B, LYS46B, LYS54F, LYS87B, LYS91B, MET100B, MET236F, MET321F, MET90B, PHE120B, PHE277F, PHE306F, PHE314F, PHE63F, PRO275F, PRO79B, PRO79F, SER235F, SER280F, SER308F, SER56F, SER81B, SER82B, SER89B, THR282F, THR55F, THR57F, THR59F, THR75B, THR93B, TYR101B, TYR35F, TYR68B, TYR68F, TYR76B, TYR76F, VAL232F, VAL234F, VAL284F, VAL65F, VAL74B, VAL74F, VAL96B
• B-G: ALA1G, ALA205G, ALA210G, ALA268B, ALA326G, ALA333G, ALA33B, ALA33G, ARG146B, ARG146G, ARG18G, ARG21G, ARG267B, ARG28B, ARG28G, ARG32B, ARG32G, ASN265B, ASN311B, ASN3G, ASP150B, ASP150G, ASP155B, ASP155G, ASP226B, ASP25G, ASP29B, ASP29G, ASP334G, GLN40B, GLN40G, GLN41B, GLN41G, GLN70G, GLU147B, GLU206G, GLU207G, GLU315B, GLU318B, GLU39B, GLU39G, GLY180G, GLY209G, GLY37B, GLY37G, HIS148B, HIS154G, HIS322B, HIS42B, HIS42G, HIS5G, ILE156G, ILE312B, ILE335G, LEU153G, LEU179G, LEU26G, LEU30G, LYS151B, LYS151G, LYS178G, LYS211G, LYS269B, LYS31B, LYS31G, LYS325G, LYS34B, LYS34G, MET181G, MET321B, PHE204G, PHE227B, PHE2G, PHE314B, PRO152B, PRO152G, PRO266B, PRO309B, SER149B, SER16G, SER208G, SER27G, SER308B, SER330G, THR17G, THR36B, THR36G, THR38B, THR38G, TYR22G, TYR310B, TYR35B, VAL329G, VAL65B
• B-J: ALA276B, ALA313B, ALA317B, ALA49J, ALA62B, ALA66B, ALA67B, ALA72B, ALA72J, ALA94J, ARG320B, ARG45J, ARG58B, ARG60B, ARG60J, ARG95J, ARG99J, ASN279B, ASN311B, ASN319B, ASN47J, ASN73B, ASN73J, ASN80B, ASN80J, ASP102J, ASP69B, ASP78B, ASP78J, ASP92J, CYS61B, GLN287B, GLN316B, GLN41B, GLN70B, GLN83J, GLU116J, GLU281B, GLU303B, GLU307B, GLU315B, GLU318B, GLU39B, GLU64B, GLU88J, GLY285B, GLY37B, GLY71B, GLY85J, GLY98J, HIS278B, HIS322B, HIS86J, ILE288B, ILE312B, ILE324B, ILE48J, ILE51J, ILE77J, ILE84J, LEU274B, LEU50B, LEU50J, LEU97J, LYS283B, LYS286B, LYS31B, LYS34B, LYS44J, LYS46J, LYS54B, LYS87J, LYS91J, MET100J, MET236B, MET321B, MET90J, PHE120J, PHE277B, PHE306B, PHE314B, PHE63B, PRO275B, PRO79B, PRO79J, SER235B, SER280B, SER308B, SER56B, SER81B, SER81J, SER82J, SER89J, THR282B, THR55B, THR57B, THR59B, THR75J, THR93J, TYR101J, TYR35B, TYR68B, TYR68J, TYR76B, TYR76J, VAL232B, VAL234B, VAL284B, VAL65B, VAL74B, VAL74J, VAL96J
• B-L: ALA1B, ALA205B, ALA210B, ALA268L, ALA326B, ALA333B, ALA33B, ALA33L, ARG146B, ARG146L, ARG18B, ARG21B, ARG267L, ARG28B, ARG28L, ARG32B, ARG32L, ASN265L, ASN311L, ASN3B, ASP150B, ASP150L, ASP155B, ASP155L, ASP226L, ASP25B, ASP29B, ASP29L, ASP334B, GLN40B, GLN40L, GLN41B, GLN41L, GLN70B, GLU147L, GLU206B, GLU207B, GLU315L, GLU318L, GLU39B, GLU39L, GLY180B, GLY209B, GLY37B, GLY37L, HIS148L, HIS154B, HIS322L, HIS42B, HIS42L, HIS5B, ILE156B, ILE312L, ILE335B, LEU153B, LEU179B, LEU26B, LEU30B, LYS151B, LYS151L, LYS178B, LYS211B, LYS269L, LYS31B, LYS31L, LYS325B, LYS34B, LYS34L, MET181B, MET321L, PHE204B, PHE227L, PHE2B, PHE314L, PRO152B, PRO152L, PRO266L, PRO309L, SER149L, SER16B, SER208B, SER27B, SER308L, SER330B, THR17B, THR36B, THR36L, THR38B, THR38L, TYR22B, TYR310L, TYR35L, VAL329B, VAL65L
• C-D: ALA276D, ALA313D, ALA317D, ALA49C, ALA62D, ALA66D, ALA67D, ALA72C, ALA72D, ALA94C, ARG320D, ARG45C, ARG58D, ARG60C, ARG60D, ARG95C, ARG99C, ASN279D, ASN311D, ASN319D, ASN47C, ASN73C, ASN73D, ASN80C, ASN80D, ASP102C, ASP69D, ASP78C, ASP78D, ASP92C, CYS61D, GLN287D, GLN316D, GLN41D, GLN70D, GLN83C, GLU116C, GLU281D, GLU303D, GLU307D, GLU315D, GLU318D, GLU39D, GLU64D, GLU88C, GLY285D, GLY37D, GLY71D, GLY85C, GLY98C, HIS278D, HIS322D, HIS86C, ILE288D, ILE312D, ILE324D, ILE48C, ILE51C, ILE77C, ILE84C, LEU274D, LEU50C, LEU50D, LEU97C, LYS283D, LYS286D, LYS31D, LYS34D, LYS44C, LYS46C, LYS54D, LYS87C, LYS91C, MET100C, MET236D, MET321D, MET90C, PHE120C, PHE277D, PHE306D, PHE314D, PHE63D, PRO275D, PRO79C, PRO79D, SER235D, SER280D, SER308D, SER56D, SER81C, SER81D, SER82C, SER89C, THR282D, THR55D, THR57D, THR59D, THR75C, THR93C, TYR101C, TYR35D, TYR68C, TYR68D, TYR76C, TYR76D, VAL232D, VAL234D, VAL284D, VAL65D, VAL74C, VAL74D, VAL96C
• C-F: ALA103C, ALA103F, ALA121C, ALA121F, ALA1C, ALA1F, ALA333C, ALA333F, ARG18C, ARG18F, ARG45C, ARG45F, ARG7C, ARG7F, ARG95C, ARG95F, ARG99C, ARG99F, ASN3C, ASN3F, ASN47C, ASN47F, ASN6C, ASN6F, ASP102C, ASP102F, ASP334C, ASP334F, GLN40C, GLN40F, GLY122C, GLY122F, GLY98C, GLY98F, HIS42C, HIS42F, HIS5C, HIS5F, ILE104C, ILE104F, ILE335C, ILE335F, LEU332C, LEU332F, LEU43C, LEU43F, LEU97C, LEU97F, LYS44C, LYS44F, LYS46C, LYS46F, MET100C, MET100F, MET4C, MET4F, PHE120C, PHE120F, PHE2C, PHE2F, PRO124C, PRO124F, THR331C, THR331F, TYR101C, TYR101F, TYR22C, TYR22F, VAL123C, VAL123F, VAL96C, VAL96F
• C-H: ALA1H, ALA205H, ALA210H, ALA268C, ALA326H, ALA333H, ALA33C, ALA33H, ARG146C, ARG146H, ARG18H, ARG21H, ARG267C, ARG28C, ARG28H, ARG32C, ARG32H, ASN265C, ASN311C, ASN3H, ASP150C, ASP150H, ASP155C, ASP155H, ASP226C, ASP25H, ASP29C, ASP29H, ASP334H, GLN40C, GLN40H, GLN41C, GLN41H, GLN70H, GLU147C, GLU206H, GLU207H, GLU315C, GLU318C, GLU39C, GLU39H, GLY180H, GLY209H, GLY37C, GLY37H, HIS148C, HIS154H, HIS322C, HIS42C, HIS42H, HIS5H, ILE156H, ILE312C, ILE335H, LEU153H, LEU179H, LEU26H, LEU30H, LYS151C, LYS151H, LYS178H, LYS211H, LYS269C, LYS31C, LYS31H, LYS325H, LYS34C, LYS34H, MET181H, MET321C, PHE204H, PHE227C, PHE2H, PHE314C, PRO152C, PRO152H, PRO266C, PRO309C, SER149C, SER16H, SER208H, SER27H, SER308C, SER330H, THR17H, THR36C, THR36H, THR38C, THR38H, TYR22H, TYR310C, TYR35C, VAL329H, VAL65C
• C-J: ALA1C, ALA205C, ALA210C, ALA268J, ALA326C, ALA333C, ALA33C, ALA33J, ARG146C, ARG146J, ARG18C, ARG21C, ARG267J, ARG28C, ARG28J, ARG32C, ARG32J, ASN265J, ASN311J, ASN3C, ASP150C, ASP150J, ASP155C, ASP155J, ASP226J, ASP25C, ASP29C, ASP29J, ASP334C, GLN40C, GLN40J, GLN41C, GLN41J, GLN70C, GLU147J, GLU206C, GLU207C, GLU315J, GLU318J, GLU39C, GLU39J, GLY180C, GLY209C, GLY37C, GLY37J, HIS148J, HIS154C, HIS322J, HIS42C, HIS42J, HIS5C, ILE156C, ILE312J, ILE335C, LEU153C, LEU179C, LEU26C, LEU30C, LYS151C, LYS151J, LYS178C, LYS211C, LYS269J, LYS31C, LYS31J, LYS325C, LYS34C, LYS34J, MET181C, MET321J, PHE204C, PHE227J, PHE2C, PHE314J, PRO152C, PRO152J, PRO266J, PRO309J, SER149J, SER16C, SER208C, SER27C, SER308J, SER330C, THR17C, THR36C, THR36J, THR38C, THR38J, TYR22C, TYR310J, TYR35J, VAL329C, VAL65J
• C-K: ALA276C, ALA313C, ALA317C, ALA49K, ALA62C, ALA66C, ALA67C, ALA72C, ALA72K, ALA94K, ARG320C, ARG45K, ARG58C, ARG60C, ARG60K, ARG95K, ARG99K, ASN279C, ASN311C, ASN319C, ASN47K, ASN73C, ASN73K, ASN80C, ASN80K, ASP102K, ASP69C, ASP78C, ASP78K, ASP92K, CYS61C, GLN287C, GLN316C, GLN41C, GLN70C, GLN83K, GLU116K, GLU281C, GLU303C, GLU307C, GLU315C, GLU318C, GLU39C, GLU64C, GLU88K, GLY285C, GLY37C, GLY71C, GLY85K, GLY98K, HIS278C, HIS322C, HIS86K, ILE288C, ILE312C, ILE324C, ILE48K, ILE51K, ILE77K, ILE84K, LEU274C, LEU50C, LEU50K, LEU97K, LYS283C, LYS286C, LYS31C, LYS34C, LYS44K, LYS46K, LYS54C, LYS87K, LYS91K, MET100K, MET236C, MET321C, MET90K, PHE120K, PHE277C, PHE306C, PHE314C, PHE63C, PRO275C, PRO79C, PRO79K, SER235C, SER280C, SER308C, SER56C, SER81K, SER82K, SER89K, THR282C, THR55C, THR57C, THR59C, THR75K, THR93K, TYR101K, TYR35C, TYR68C, TYR68K, TYR76C, TYR76K, VAL232C, VAL234C, VAL284C, VAL65C, VAL74C, VAL74K, VAL96K
• D-E: ALA1D, ALA205D, ALA210D, ALA268E, ALA326D, ALA333D, ALA33D, ALA33E, ARG146D, ARG146E, ARG18D, ARG21D, ARG267E, ARG28D, ARG28E, ARG32D, ARG32E, ASN265E, ASN311E, ASN3D, ASP150D, ASP150E, ASP155D, ASP155E, ASP226E, ASP25D, ASP29D, ASP29E, ASP334D, GLN40D, GLN40E, GLN41D, GLN41E, GLN70D, GLU147E, GLU206D, GLU207D, GLU315E, GLU318E, GLU39D, GLU39E, GLY180D, GLY209D, GLY37D, GLY37E, HIS148E, HIS154D, HIS322E, HIS42D, HIS42E, HIS5D, ILE156D, ILE312E, ILE335D, LEU153D, LEU179D, LEU26D, LEU30D, LYS151D, LYS151E, LYS178D, LYS211D, LYS269E, LYS31D, LYS31E, LYS325D, LYS34D, LYS34E, MET181D, MET321E, PHE204D, PHE227E, PHE2D, PHE314E, PRO152D, PRO152E, PRO266E, PRO309E, SER149E, SER16D, SER208D, SER27D, SER308E, SER330D, THR17D, THR36D, THR36E, THR38D, THR38E, TYR22D, TYR310E, TYR35E, VAL329D, VAL65E
• D-F: ALA1F, ALA205F, ALA210F, ALA268D, ALA326F, ALA333F, ALA33D, ALA33F, ARG146D, ARG146F, ARG18F, ARG21F, ARG267D, ARG28D, ARG28F, ARG32D, ARG32F, ASN265D, ASN311D, ASN3F, ASP150D, ASP150F, ASP155D, ASP155F, ASP226D, ASP25F, ASP29D, ASP29F, ASP334F, GLN40D, GLN40F, GLN41D, GLN41F, GLN70F, GLU147D, GLU206F, GLU207F, GLU315D, GLU318D, GLU39D, GLU39F, GLY180F, GLY209F, GLY37D, GLY37F, HIS148D, HIS154F, HIS322D, HIS42D, HIS42F, HIS5F, ILE156F, ILE312D, ILE335F, LEU153F, LEU179F, LEU26F, LEU30F, LYS151D, LYS151F, LYS178F, LYS211F, LYS269D, LYS31D, LYS31F, LYS325F, LYS34D, LYS34F, MET181F, MET321D, PHE204F, PHE227D, PHE2F, PHE314D, PRO152D, PRO152F, PRO266D, PRO309D, SER149D, SER16F, SER208F, SER27F, SER308D, SER330F, THR17F, THR36D, THR36F, THR38D, THR38F, TYR22F, TYR310D, TYR35D, VAL329F, VAL65D
• D-K: ALA276K, ALA313K, ALA317K, ALA49D, ALA62K, ALA66K, ALA67K, ALA72D, ALA72K, ALA94D, ARG320K, ARG45D, ARG58K, ARG60D, ARG60K, ARG95D, ARG99D, ASN279K, ASN311K, ASN319K, ASN47D, ASN73D, ASN73K, ASN80D, ASN80K, ASP102D, ASP69K, ASP78D, ASP78K, ASP92D, CYS61K, GLN287K, GLN316K, GLN41K, GLN70K, GLN83D, GLU116D, GLU281K, GLU303K, GLU307K, GLU315K, GLU318K, GLU39K, GLU64K, GLU88D, GLY285K, GLY37K, GLY71K, GLY85D, GLY98D, HIS278K, HIS322K, HIS86D, ILE288K, ILE312K, ILE324K, ILE48D, ILE51D, ILE77D, ILE84D, LEU274K, LEU50D, LEU50K, LEU97D, LYS283K, LYS286K, LYS31K, LYS34K, LYS44D, LYS46D, LYS54K, LYS87D, LYS91D, MET100D, MET236K, MET321K, MET90D, PHE120D, PHE277K, PHE306K, PHE314K, PHE63K, PRO275K, PRO79D, PRO79K, SER235K, SER280K, SER308K, SER56K, SER81D, SER82D, SER89D, THR282K, THR55K, THR57K, THR59K, THR75D, THR93D, TYR101D, TYR35K, TYR68D, TYR68K, TYR76D, TYR76K, VAL232K, VAL234K, VAL284K, VAL65K, VAL74D, VAL74K, VAL96D
• E-F: ALA1E, ALA205E, ALA210E, ALA268F, ALA326E, ALA333E, ALA33E, ALA33F, ARG146E, ARG146F, ARG18E, ARG21E, ARG267F, ARG28E, ARG28F, ARG32E, ARG32F, ASN265F, ASN311F, ASN3E, ASP150E, ASP150F, ASP155E, ASP155F, ASP226F, ASP25E, ASP29E, ASP29F, ASP334E, GLN40E, GLN40F, GLN41E, GLN41F, GLN70E, GLU147F, GLU206E, GLU207E, GLU315F, GLU318F, GLU39E, GLU39F, GLY180E, GLY209E, GLY37E, GLY37F, HIS148F, HIS154E, HIS322F, HIS42E, HIS42F, HIS5E, ILE156E, ILE312F, ILE335E, LEU153E, LEU179E, LEU26E, LEU30E, LYS151E, LYS151F, LYS178E, LYS211E, LYS269F, LYS31E, LYS31F, LYS325E, LYS34E, LYS34F, MET181E, MET321F, PHE204E, PHE227F, PHE2E, PHE314F, PRO152E, PRO152F, PRO266F, PRO309F, SER149F, SER16E, SER208E, SER27E, SER308F, SER330E, THR17E, THR36E, THR36F, THR38E, THR38F, TYR22E, TYR310F, TYR35F, VAL329E, VAL65F
• E-L: ALA276L, ALA313L, ALA317L, ALA49E, ALA62L, ALA66L, ALA67L, ALA72E, ALA72L, ALA94E, ARG320L, ARG45E, ARG58L, ARG60E, ARG60L, ARG95E, ARG99E, ASN279L, ASN311L, ASN319L, ASN47E, ASN73E, ASN73L, ASN80E, ASN80L, ASP102E, ASP69L, ASP78E, ASP78L, ASP92E, CYS61L, GLN287L, GLN316L, GLN41L, GLN70L, GLN83E, GLU116E, GLU281L, GLU303L, GLU307L, GLU315L, GLU318L, GLU39L, GLU64L, GLU88E, GLY285L, GLY37L, GLY71L, GLY85E, GLY98E, HIS278L, HIS322L, HIS86E, ILE288L, ILE312L, ILE324L, ILE48E, ILE51E, ILE77E, ILE84E, LEU274L, LEU50E, LEU50L, LEU97E, LYS283L, LYS286L, LYS31L, LYS34L, LYS44E, LYS46E, LYS54L, LYS87E, LYS91E, MET100E, MET236L, MET321L, MET90E, PHE120E, PHE277L, PHE306L, PHE314L, PHE63L, PRO275L, PRO79E, PRO79L, SER235L, SER280L, SER308L, SER56L, SER81E, SER82E, SER89E, THR282L, THR55L, THR57L, THR59L, THR75E, THR93E, TYR101E, TYR35L, TYR68E, TYR68L, TYR76E, TYR76L, VAL232L, VAL234L, VAL284L, VAL65L, VAL74E, VAL74L, VAL96E
• F-J: ALA276J, ALA313J, ALA317J, ALA49F, ALA62J, ALA66J, ALA67J, ALA72F, ALA72J, ALA94F, ARG320J, ARG45F, ARG58J, ARG60F, ARG60J, ARG95F, ARG99F, ASN279J, ASN311J, ASN319J, ASN47F, ASN73F, ASN73J, ASN80F, ASN80J, ASP102F, ASP69J, ASP78F, ASP78J, ASP92F, CYS61J, GLN287J, GLN316J, GLN41J, GLN70J, GLN83F, GLU116F, GLU281J, GLU303J, GLU307J, GLU315J, GLU318J, GLU39J, GLU64J, GLU88F, GLY285J, GLY37J, GLY71J, GLY85F, GLY98F, HIS278J, HIS322J, HIS86F, ILE288J, ILE312J, ILE324J, ILE48F, ILE51F, ILE77F, ILE84F, LEU274J, LEU50F, LEU50J, LEU97F, LYS283J, LYS286J, LYS31J, LYS34J, LYS44F, LYS46F, LYS54J, LYS87F, LYS91F, MET100F, MET236J, MET321J, MET90F, PHE120F, PHE277J, PHE306J, PHE314J, PHE63J, PRO275J, PRO79F, PRO79J, SER235J, SER280J, SER308J, SER56J, SER81F, SER82F, SER89F, THR282J, THR55J, THR57J, THR59J, THR75F, THR93F, TYR101F, TYR35J, TYR68F, TYR68J, TYR76F, TYR76J, VAL232J, VAL234J, VAL284J, VAL65J, VAL74F, VAL74J, VAL96F
• G-H: ALA276H, ALA313H, ALA317H, ALA49G, ALA62H, ALA66H, ALA67H, ALA72G, ALA72H, ALA94G, ARG320H, ARG45G, ARG58H, ARG60G, ARG60H, ARG95G, ARG99G, ASN279H, ASN311H, ASN319H, ASN47G, ASN73G, ASN73H, ASN80G, ASN80H, ASP102G, ASP69H, ASP78G, ASP78H, ASP92G, CYS61H, GLN287H, GLN316H, GLN41H, GLN70H, GLN83G, GLU116G, GLU281H, GLU303H, GLU307H, GLU315H, GLU318H, GLU39H, GLU64H, GLU88G, GLY285H, GLY37H, GLY71H, GLY85G, GLY98G, HIS278H, HIS322H, HIS86G, ILE288H, ILE312H, ILE324H, ILE48G, ILE51G, ILE77G, ILE84G, LEU274H, LEU50G, LEU50H, LEU97G, LYS283H, LYS286H, LYS31H, LYS34H, LYS44G, LYS46G, LYS54H, LYS87G, LYS91G, MET100G, MET236H, MET321H, MET90G, PHE120G, PHE277H, PHE306H, PHE314H, PHE63H, PRO275H, PRO79G, PRO79H, SER235H, SER280H, SER308H, SER56H, SER81G, SER82G, SER89G, THR282H, THR55H, THR57H, THR59H, THR75G, THR93G, TYR101G, TYR35H, TYR68G, TYR68H, TYR76G, TYR76H, VAL232H, VAL234H, VAL284H, VAL65H, VAL74G, VAL74H, VAL96G
• G-I: ALA276G, ALA313G, ALA317G, ALA49I, ALA62G, ALA66G, ALA67G, ALA72G, ALA72I, ALA94I, ARG320G, ARG45I, ARG58G, ARG60G, ARG60I, ARG95I, ARG99I, ASN279G, ASN311G, ASN319G, ASN47I, ASN73G, ASN73I, ASN80G, ASN80I, ASP102I, ASP69G, ASP78G, ASP78I, ASP92I, CYS61G, GLN287G, GLN316G, GLN41G, GLN70G, GLN83I, GLU116I, GLU281G, GLU303G, GLU307G, GLU315G, GLU318G, GLU39G, GLU64G, GLU88I, GLY285G, GLY37G, GLY71G, GLY85I, GLY98I, HIS278G, HIS322G, HIS86I, ILE288G, ILE312G, ILE324G, ILE48I, ILE51I, ILE77I, ILE84I, LEU274G, LEU50G, LEU50I, LEU97I, LYS283G, LYS286G, LYS31G, LYS34G, LYS44I, LYS46I, LYS54G, LYS87I, LYS91I, MET100I, MET236G, MET321G, MET90I, PHE120I, PHE277G, PHE306G, PHE314G, PHE63G, PRO275G, PRO79G, PRO79I, SER235G, SER280G, SER308G, SER56G, SER81G, SER81I, SER82I, SER89I, THR282G, THR55G, THR57G, THR59G, THR75I, THR93I, TYR101I, TYR35G, TYR68G, TYR68I, TYR76G, TYR76I, VAL232G, VAL234G, VAL284G, VAL65G, VAL74G, VAL74I, VAL96I
• G-J: ALA103G, ALA103J, ALA121G, ALA121J, ALA1G, ALA1J, ALA333G, ALA333J, ARG18G, ARG18J, ARG45G, ARG45J, ARG7G, ARG7J, ARG95G, ARG95J, ARG99G, ARG99J, ASN3G, ASN3J, ASN47G, ASN47J, ASN6G, ASN6J, ASP102G, ASP102J, ASP334G, ASP334J, GLN40G, GLN40J, GLY122G, GLY122J, GLY98G, GLY98J, HIS42G, HIS42J, HIS5G, HIS5J, ILE104G, ILE104J, ILE335G, ILE335J, LEU332G, LEU332J, LEU43G, LEU43J, LEU97G, LEU97J, LYS44G, LYS44J, LYS46G, LYS46J, MET100G, MET100J, MET4G, MET4J, PHE120G, PHE120J, PHE2G, PHE2J, PRO124G, PRO124J, THR331G, THR331J, TYR101G, TYR101J, TYR22G, TYR22J, VAL123G, VAL123J, VAL96G, VAL96J
• G-L: ALA1L, ALA205L, ALA210L, ALA268G, ALA326L, ALA333L, ALA33G, ALA33L, ARG146G, ARG146L, ARG18L, ARG21L, ARG267G, ARG28G, ARG28L, ARG32G, ARG32L, ASN265G, ASN311G, ASN3L, ASP150G, ASP150L, ASP155G, ASP155L, ASP226G, ASP25L, ASP29G, ASP29L, ASP334L, GLN40G, GLN40L, GLN41G, GLN41L, GLN70L, GLU147G, GLU206L, GLU207L, GLU315G, GLU318G, GLU39G, GLU39L, GLY180L, GLY209L, GLY37G, GLY37L, HIS148G, HIS154L, HIS322G, HIS42G, HIS42L, HIS5L, ILE156L, ILE312G, ILE335L, LEU153L, LEU179L, LEU26L, LEU30L, LYS151G, LYS151L, LYS178L, LYS211L, LYS269G, LYS31G, LYS31L, LYS325L, LYS34G, LYS34L, MET181L, MET321G, PHE204L, PHE227G, PHE2L, PHE314G, PRO152G, PRO152L, PRO266G, PRO309G, SER149G, SER16L, SER208L, SER27L, SER308G, SER330L, THR17L, THR36G, THR36L, THR38G, THR38L, TYR22L, TYR310G, TYR35G, VAL329L, VAL65G
• H-I: ALA276I, ALA313I, ALA317I, ALA49H, ALA62I, ALA66I, ALA67I, ALA72H, ALA72I, ALA94H, ARG320I, ARG45H, ARG58I, ARG60H, ARG60I, ARG95H, ARG99H, ASN279I, ASN311I, ASN319I, ASN47H, ASN73H, ASN73I, ASN80H, ASN80I, ASP102H, ASP69I, ASP78H, ASP78I, ASP92H, CYS61I, GLN287I, GLN316I, GLN41I, GLN70I, GLN83H, GLU116H, GLU281I, GLU303I, GLU307I, GLU315I, GLU318I, GLU39I, GLU64I, GLU88H, GLY285I, GLY37I, GLY71I, GLY85H, GLY98H, HIS278I, HIS322I, HIS86H, ILE288I, ILE312I, ILE324I, ILE48H, ILE51H, ILE77H, ILE84H, LEU274I, LEU50H, LEU50I, LEU97H, LYS283I, LYS286I, LYS31I, LYS34I, LYS44H, LYS46H, LYS54I, LYS87H, LYS91H, MET100H, MET236I, MET321I, MET90H, PHE120H, PHE277I, PHE306I, PHE314I, PHE63I, PRO275I, PRO79H, PRO79I, SER235I, SER280I, SER308I, SER56I, SER81H, SER82H, SER89H, THR282I, THR55I, THR57I, THR59I, THR75H, THR93H, TYR101H, TYR35I, TYR68H, TYR68I, TYR76H, TYR76I, VAL232I, VAL234I, VAL284I, VAL65I, VAL74H, VAL74I, VAL96H
• H-J: ALA1J, ALA205J, ALA210J, ALA268H, ALA326J, ALA333J, ALA33H, ALA33J, ARG146H, ARG146J, ARG18J, ARG21J, ARG267H, ARG28H, ARG28J, ARG32H, ARG32J, ASN265H, ASN311H, ASN3J, ASP150H, ASP150J, ASP155H, ASP155J, ASP226H, ASP25J, ASP29H, ASP29J, ASP334J, GLN40H, GLN40J, GLN41H, GLN41J, GLN70J, GLU147H, GLU206J, GLU207J, GLU315H, GLU318H, GLU39H, GLU39J, GLY180J, GLY209J, GLY37H, GLY37J, HIS148H, HIS154J, HIS322H, HIS42H, HIS42J, HIS5J, ILE156J, ILE312H, ILE335J, LEU153J, LEU179J, LEU26J, LEU30J, LYS151H, LYS151J, LYS178J, LYS211J, LYS269H, LYS31H, LYS31J, LYS325J, LYS34H, LYS34J, MET181J, MET321H, PHE204J, PHE227H, PHE2J, PHE314H, PRO152H, PRO152J, PRO266H, PRO309H, SER149H, SER16J, SER208J, SER27J, SER308H, SER330J, THR17J, THR36H, THR36J, THR38H, THR38J, TYR22J, TYR310H, TYR35H, VAL329J, VAL65H
• H-K: ALA103H, ALA103K, ALA121H, ALA121K, ALA1H, ALA1K, ALA333H, ALA333K, ARG18H, ARG18K, ARG45H, ARG45K, ARG7H, ARG7K, ARG95H, ARG95K, ARG99H, ARG99K, ASN3H, ASN3K, ASN47H, ASN47K, ASN6H, ASN6K, ASP102H, ASP102K, ASP334H, ASP334K, GLN40H, GLN40K, GLY122H, GLY122K, GLY98H, GLY98K, HIS42H, HIS42K, HIS5H, HIS5K, ILE104H, ILE104K, ILE335H, ILE335K, LEU332H, LEU332K, LEU43H, LEU43K, LEU97H, LEU97K, LYS44H, LYS44K, LYS46H, LYS46K, MET100H, MET100K, MET4H, MET4K, PHE120H, PHE120K, PHE2H, PHE2K, PRO124H, PRO124K, THR331H, THR331K, TYR101H, TYR101K, TYR22H, TYR22K, VAL123H, VAL123K, VAL96H, VAL96K
• I-K: ALA1K, ALA205K, ALA210K, ALA268I, ALA326K, ALA333K, ALA33I, ALA33K, ARG146I, ARG146K, ARG18K, ARG21K, ARG267I, ARG28I, ARG28K, ARG32I, ARG32K, ASN265I, ASN311I, ASN3K, ASP150I, ASP150K, ASP155I, ASP155K, ASP226I, ASP25K, ASP29I, ASP29K, ASP334K, GLN40I, GLN40K, GLN41I, GLN41K, GLN70K, GLU147I, GLU206K, GLU207K, GLU315I, GLU318I, GLU39I, GLU39K, GLY180K, GLY209K, GLY37I, GLY37K, HIS148I, HIS154K, HIS322I, HIS42I, HIS42K, HIS5K, ILE156K, ILE312I, ILE335K, LEU153K, LEU179K, LEU26K, LEU30K, LYS151I, LYS151K, LYS178K, LYS211K, LYS269I, LYS31I, LYS31K, LYS325K, LYS34I, LYS34K, MET181K, MET321I, PHE204K, PHE227I, PHE2K, PHE314I, PRO152I, PRO152K, PRO266I, PRO309I, SER149I, SER16K, SER208K, SER27K, SER308I, SER330K, THR17K, THR36I, THR36K, THR38I, THR38K, TYR22K, TYR310I, TYR35I, VAL329K, VAL65I
• I-L: ALA103I, ALA103L, ALA121I, ALA121L, ALA1I, ALA1L, ALA333I, ALA333L, ARG18I, ARG18L, ARG45I, ARG45L, ARG7I, ARG7L, ARG95I, ARG95L, ARG99I, ARG99L, ASN3I, ASN3L, ASN47I, ASN47L, ASN6I, ASN6L, ASP102I, ASP102L, ASP334I, ASP334L, GLN40I, GLN40L, GLY122I, GLY122L, GLY98I, GLY98L, HIS42I, HIS42L, HIS5I, HIS5L, ILE104I, ILE104L, ILE335I, ILE335L, LEU332I, LEU332L, LEU43I, LEU43L, LEU97I, LEU97L, LYS44I, LYS44L, LYS46I, LYS46L, MET100I, MET100L, MET4I, MET4L, PHE120I, PHE120L, PHE2I, PHE2L, PRO124I, PRO124L, THR331I, THR331L, TYR101I, TYR101L, TYR22I, TYR22L, VAL123I, VAL123L, VAL96I, VAL96L