1ON9

transcarboxylase 12s crystal structure: hexamer assembly and substrate binding to a multienzyme core (with hydrolyzed methylmalonyl-coenzyme a bound)

• Total interactions analyzed: 15
• Total true interactions: 15
• Strongest Interaction:
  • Chains: A-D
  • Int. Res.: 435
  • Norm. En. per Res.: -4.8492
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-57.4614	22.7753	-331.867	-366.5531	136	30	5	14032	5	44	49
A-C	-51.7174	2.6501	-324.416	-373.4834	131	20	5	13542	5	44	48
A-D	-317.2767	-263.4535	-1528.66	-2109.3902	435	88	73	59534	14	69	93
A-E	0.0	0.0	-0.5415	-0.5415	10	0	0	121	0	0	4
A-F	-20.7134	-53.4845	-26.7375	-100.9354	28	2	0	1311	8	19	9
B-C	-45.6628	-11.3675	-308.141	-365.1713	131	17	5	13207	5	46	48
B-D	-20.593	-66.55	-36.3417	-123.4847	29	4	0	1394	8	18	9
B-E	-279.2339	-242.3877	-1521.72	-2043.3416	434	86	73	59354	13	69	89
B-F	0.0	0.0	-0.0086	-0.0086	5	0	0	11	0	0	4
C-D	0.0	0.0	-0.7837	-0.7837	9	0	0	174	0	0	4
C-E	-28.2727	-27.0584	-36.7173	-92.0484	33	6	0	1432	10	18	9
C-F	-262.5306	-242.8929	-1530.3	-2035.7235	437	65	73	59357	13	68	88
D-E	-45.721	-61.8095	-326.807	-434.3375	132	18	6	13942	6	49	50
D-F	-54.6103	-21.2047	-368.635	-444.45	135	14	5	15047	7	47	49
E-F	-51.3353	-77.3655	-323.664	-452.3648	132	19	6	13993	8	47	48

Interface residues

• A-B: ALA100B, ALA10B, ALA127B, ALA21B, ALA426A, ALA428A, ALA431A, ALA435A, ALA481A, ALA482A, ALA483A, ALA494A, ALA501A, ALA503A, ALA508A, ALA65B, ALA83B, ARG16B, ARG24B, ARG280A, ARG409A, ARG422A, ARG484A, ARG498A, ARG511A, ARG67B, ARG70B, ARG90B, ARG96B, ASN259B, ASN260B, ASN473A, ASN476A, ASP281A, ASP286A, ASP427A, ASP488A, ASP489A, ASP492A, ASP495A, ASP61B, ASP84B, GLN126B, GLN19B, GLN23B, GLN258B, GLN472A, GLN486A, GLN512A, GLU114B, GLU122B, GLU125B, GLU14B, GLU18B, GLU22B, GLU262B, GLU278A, GLU436A, GLU469A, GLU505A, GLU62B, GLY131B, GLY15B, GLY287A, GLY425A, GLY485A, GLY64B, GLY89B, GLY91B, GLY95B, HIS58B, HIS69B, HIS99B, ILE27B, ILE282A, ILE285A, ILE404A, ILE491A, ILE500A, LEU128B, LEU129B, LEU20B, LEU279A, LEU408A, LEU504A, LEU9B, LYS119B, LYS164B, LYS403A, LYS499A, LYS510A, LYS68B, MET13B, MET506A, PHE475A, PHE60B, PHE66B, PRO133B, PRO284A, PRO402A, PRO433A, PRO478A, PRO493A, PRO97B, SER11B, SER434A, SER502A, SER59B, THR115B, THR118B, THR123B, THR12B, THR130B, THR132B, THR261B, THR277A, THR400A, THR477A, THR509A, THR513A, THR71B, THR92B, TRP432A, TYR430A, TYR479A, TYR507A, VAL168B, VAL17B, VAL283A, VAL401A, VAL429A, VAL480A, VAL487A, VAL490A, VAL63B, VAL98B
• A-C: ALA100A, ALA10A, ALA127A, ALA21A, ALA426C, ALA428C, ALA431C, ALA435C, ALA481C, ALA482C, ALA483C, ALA494C, ALA501C, ALA503C, ALA508C, ALA65A, ALA83A, ARG16A, ARG24A, ARG280C, ARG409C, ARG422C, ARG484C, ARG498C, ARG511C, ARG67A, ARG70A, ARG90A, ARG96A, ASN259A, ASN473C, ASN476C, ASP281C, ASP286C, ASP427C, ASP488C, ASP489C, ASP492C, ASP495C, ASP61A, ASP84A, GLN126A, GLN19A, GLN23A, GLN258A, GLN472C, GLN486C, GLN512C, GLU122A, GLU125A, GLU14A, GLU18A, GLU22A, GLU262A, GLU278C, GLU436C, GLU469C, GLU505C, GLU62A, GLY131A, GLY15A, GLY287C, GLY425C, GLY485C, GLY64A, GLY89A, GLY91A, GLY95A, HIS58A, HIS69A, HIS99A, ILE27A, ILE282C, ILE285C, ILE404C, ILE491C, ILE500C, LEU128A, LEU129A, LEU20A, LEU279C, LEU408C, LEU504C, LEU9A, LYS119A, LYS403C, LYS499C, LYS510C, LYS68A, MET13A, MET506C, PHE475C, PHE60A, PHE66A, PRO133A, PRO284C, PRO402C, PRO433C, PRO478C, PRO493C, PRO97A, SER11A, SER434C, SER502C, SER59A, THR115A, THR118A, THR123A, THR12A, THR130A, THR132A, THR261A, THR277C, THR400C, THR477C, THR509C, THR513C, THR92A, TRP432C, TYR430C, TYR479C, TYR507C, VAL17A, VAL283C, VAL401C, VAL429C, VAL480C, VAL487C, VAL490C, VAL63A, VAL98A
• A-D: ALA112A, ALA112D, ALA143A, ALA143D, ALA161A, ALA161D, ALA180A, ALA180D, ALA183A, ALA183D, ALA188A, ALA188D, ALA219A, ALA219D, ALA227A, ALA227D, ALA230A, ALA230D, ALA314A, ALA314D, ALA351A, ALA351D, ALA352A, ALA352D, ALA390A, ALA390D, ALA395A, ALA395D, ALA399A, ALA399D, ALA411A, ALA411D, ALA418A, ALA418D, ALA426A, ALA426D, ALA438A, ALA438D, ALA442A, ALA442D, ALA445A, ALA445D, ALA446A, ALA446D, ALA474A, ALA474D, ALA481A, ALA481D, ALA482A, ALA482D, ALA483A, ALA483D, ALA516A, ALA516D, ARG144A, ARG144D, ARG387A, ARG387D, ARG422A, ARG422D, ARG451A, ARG484A, ARG484D, ARG514A, ARG514D, ARG70A, ARG70D, ASN162A, ASN162D, ASN234A, ASN234D, ASN260A, ASN260D, ASN346A, ASN346D, ASN356A, ASN356D, ASN362A, ASN362D, ASN421A, ASN421D, ASN447A, ASN447D, ASN473A, ASN473D, ASN476A, ASN476D, ASN521A, ASN521D, ASP150A, ASP150D, ASP191A, ASP191D, ASP216A, ASP216D, ASP220A, ASP220D, ASP344A, ASP344D, ASP349A, ASP349D, ASP359A, ASP359D, ASP423A, ASP423D, CYS179A, CYS179D, CYS342A, CYS342D, CYS358A, CYS358D, CYS420A, CYS420D, CYS524A, CYS524D, GLN146A, GLN146D, GLN171A, GLN171D, GLN207A, GLN207D, GLN379A, GLN379D, GLN380A, GLN380D, GLN472A, GLN472D, GLN486A, GLN486D, GLN512A, GLN512D, GLU114A, GLU114D, GLU125A, GLU125D, GLU147A, GLU147D, GLU215A, GLU215D, GLU221A, GLU221D, GLU353A, GLU353D, GLU381A, GLU381D, GLU398A, GLU398D, GLU436A, GLU436D, GLU466A, GLU469A, GLU469D, GLU470A, GLU470D, GLY141A, GLY142A, GLY142D, GLY148A, GLY148D, GLY154A, GLY154D, GLY156A, GLY156D, GLY167A, GLY167D, GLY181A, GLY181D, GLY182A, GLY182D, GLY205A, GLY205D, GLY214A, GLY214D, GLY223A, GLY223D, GLY224A, GLY224D, GLY233A, GLY233D, GLY373A, GLY373D, GLY377A, GLY377D, GLY383A, GLY383D, GLY384A, GLY384D, GLY389A, GLY389D, GLY413A, GLY413D, GLY414A, GLY414D, GLY425A, GLY425D, GLY441A, GLY441D, GLY444A, GLY444D, GLY485A, GLY485D, GLY520A, GLY520D, GLY75A, GLY75D, HIS200A, HIS200D, HIS228A, HIS228D, HIS236A, HIS236D, HIS388A, HIS388D, HIS519A, HIS519D, ILE145A, ILE145D, ILE149A, ILE149D, ILE175A, ILE175D, ILE193A, ILE193D, ILE203A, ILE203D, ILE209A, ILE209D, ILE231A, ILE231D, ILE235A, ILE235D, ILE345A, ILE345D, ILE363A, ILE363D, ILE385A, ILE385D, ILE386A, ILE386D, ILE437A, ILE437D, ILE449A, ILE449D, ILE468A, ILE468D, LEU128A, LEU128D, LEU152A, LEU152D, LEU165A, LEU165D, LEU189A, LEU189D, LEU222A, LEU222D, LEU343A, LEU343D, LEU365A, LEU365D, LEU375A, LEU375D, LEU393A, LEU393D, LEU417A, LEU417D, LEU424A, LEU424D, LEU73A, LEU73D, LYS157A, LYS157D, LYS164A, LYS164D, LYS210A, LYS210D, LYS310A, LYS310D, LYS350A, LYS350D, LYS391A, LYS391D, LYS403A, LYS403D, LYS467A, LYS467D, LYS510A, LYS510D, LYS517A, LYS517D, LYS518A, LYS518D, MET108A, MET108D, MET158A, MET158D, MET195A, MET195D, MET201A, MET201D, MET392A, MET392D, MET440A, MET440D, MET76A, MET76D, PHE159A, PHE159D, PHE160A, PHE160D, PHE192A, PHE192D, PHE202A, PHE202D, PHE354A, PHE354D, PHE357A, PHE357D, PHE361A, PHE361D, PHE374A, PHE374D, PHE450A, PHE450D, PHE475A, PHE475D, PHE522A, PHE522D, PHE74A, PHE74D, PRO170A, PRO170D, PRO187A, PRO187D, PRO206A, PRO206D, PRO376A, PRO376D, PRO402A, PRO402D, PRO478A, PRO478D, PRO515A, PRO515D, PRO523A, PRO523D, SER151A, SER151D, SER153A, SER153D, SER166A, SER166D, SER184A, SER184D, SER186A, SER186D, SER211A, SER211D, SER232A, SER232D, SER348A, SER348D, SER360A, SER360D, SER397A, SER397D, SER415A, SER415D, THR190A, THR190D, THR204A, THR204D, THR213A, THR213D, THR218A, THR218D, THR261A, THR261D, THR400A, THR400D, THR477A, THR477D, THR513A, THR513D, THR71A, THR71D, THR72A, THR72D, TYR155A, TYR155D, TYR185A, TYR185D, TYR313A, TYR313D, TYR382A, TYR382D, TYR394A, TYR394D, TYR396A, TYR396D, TYR412A, TYR412D, TYR416A, TYR416D, TYR471A, TYR471D, TYR479A, TYR479D, VAL121A, VAL121D, VAL163A, VAL163D, VAL168A, VAL168D, VAL169A, VAL169D, VAL208A, VAL208D, VAL212A, VAL212D, VAL217A, VAL217D, VAL355A, VAL355D, VAL378A, VAL378D, VAL401A, VAL401D, VAL439A, VAL439D, VAL448A, VAL448D, VAL480A, VAL480D, VAL487A, VAL487D
• A-E: ALA516A, ALA516E, ARG511A, ARG514A, ARG514E, LYS517E, PRO515A, PRO515E, THR513A, THR513E
• A-F: ARG67A, ARG67F, ARG70A, ARG70F, ASP150A, ASP150F, ASP77A, ASP77F, GLU114A, GLU114F, GLU147A, GLU147F, HIS69A, HIS69F, ILE149A, ILE149F, LEU73A, LEU73F, LYS157A, LYS157F, MET76F, SER151A, SER153A, THR115A, THR71A, THR71F, THR72A, THR72F
• B-C: ALA10C, ALA127C, ALA21C, ALA426B, ALA428B, ALA431B, ALA435B, ALA481B, ALA482B, ALA483B, ALA494B, ALA501B, ALA503B, ALA508B, ALA65C, ALA83C, ARG16C, ARG24C, ARG280B, ARG409B, ARG422B, ARG484B, ARG498B, ARG511B, ARG514B, ARG67C, ARG70C, ARG90C, ASN259C, ASN473B, ASN476B, ASP281B, ASP286B, ASP427B, ASP488B, ASP489B, ASP492B, ASP495B, ASP61C, ASP84C, GLN126C, GLN19C, GLN23C, GLN258C, GLN472B, GLN486B, GLN512B, GLU122C, GLU125C, GLU14C, GLU18C, GLU22C, GLU262C, GLU278B, GLU436B, GLU469B, GLU505B, GLU62C, GLY131C, GLY15C, GLY287B, GLY425B, GLY485B, GLY64C, GLY89C, GLY91C, GLY95C, HIS58C, HIS69C, HIS99C, ILE27C, ILE282B, ILE285B, ILE404B, ILE491B, ILE500B, LEU128C, LEU129C, LEU20C, LEU279B, LEU408B, LEU504B, LEU9C, LYS119C, LYS403B, LYS499B, LYS510B, LYS68C, LYS8C, MET13C, MET506B, PHE475B, PHE60C, PHE66C, PRO133C, PRO284B, PRO402B, PRO433B, PRO478B, PRO493B, PRO97C, SER11C, SER434B, SER502B, SER59C, THR115C, THR118C, THR123C, THR12C, THR130C, THR132C, THR261C, THR277B, THR400B, THR477B, THR509B, THR513B, THR92C, TRP432B, TYR430B, TYR479B, TYR507B, VAL17C, VAL283B, VAL401B, VAL429B, VAL480B, VAL487B, VAL490B, VAL63C, VAL98C
• B-D: ARG67B, ARG67D, ARG70B, ARG70D, ASP150B, ASP150D, ASP77B, ASP77D, GLU114B, GLU114D, GLU147B, GLU147D, HIS69B, HIS69D, ILE149B, ILE149D, LEU73B, LEU73D, LYS157B, LYS157D, SER151B, SER153B, THR115B, THR115D, THR118D, THR71B, THR71D, THR72B, THR72D
• B-E: ALA112B, ALA112E, ALA143B, ALA143E, ALA161B, ALA161E, ALA180B, ALA180E, ALA183B, ALA183E, ALA188B, ALA188E, ALA219B, ALA219E, ALA227B, ALA227E, ALA230B, ALA230E, ALA314B, ALA314E, ALA351B, ALA351E, ALA352B, ALA352E, ALA390B, ALA390E, ALA395B, ALA395E, ALA399B, ALA399E, ALA411B, ALA411E, ALA418B, ALA418E, ALA426B, ALA426E, ALA438B, ALA438E, ALA442B, ALA442E, ALA445B, ALA445E, ALA446B, ALA446E, ALA474B, ALA474E, ALA481B, ALA481E, ALA482B, ALA482E, ALA483B, ALA483E, ALA516B, ALA516E, ARG144B, ARG144E, ARG387B, ARG387E, ARG422B, ARG422E, ARG484B, ARG484E, ARG511E, ARG514B, ARG514E, ARG70B, ARG70E, ASN162B, ASN162E, ASN234B, ASN234E, ASN260B, ASN260E, ASN346B, ASN346E, ASN356B, ASN356E, ASN362B, ASN362E, ASN421B, ASN421E, ASN447B, ASN447E, ASN473B, ASN473E, ASN476B, ASN476E, ASN521B, ASN521E, ASP150B, ASP150E, ASP191B, ASP191E, ASP216B, ASP216E, ASP220B, ASP220E, ASP344B, ASP344E, ASP349B, ASP349E, ASP359B, ASP359E, ASP423B, ASP423E, CYS179B, CYS179E, CYS342B, CYS342E, CYS358B, CYS358E, CYS420B, CYS420E, CYS524B, CYS524E, GLN146B, GLN146E, GLN171B, GLN171E, GLN207B, GLN207E, GLN379B, GLN379E, GLN380B, GLN380E, GLN472B, GLN472E, GLN486B, GLN486E, GLN512B, GLN512E, GLU114B, GLU114E, GLU125B, GLU125E, GLU147B, GLU147E, GLU215B, GLU215E, GLU221B, GLU221E, GLU353B, GLU353E, GLU381B, GLU381E, GLU398B, GLU398E, GLU436B, GLU436E, GLU466B, GLU466E, GLU469B, GLU469E, GLU470B, GLU470E, GLY142B, GLY142E, GLY148B, GLY148E, GLY154B, GLY154E, GLY156B, GLY156E, GLY167B, GLY167E, GLY181B, GLY181E, GLY182B, GLY182E, GLY205B, GLY205E, GLY214B, GLY214E, GLY223B, GLY223E, GLY224B, GLY224E, GLY233B, GLY233E, GLY373B, GLY373E, GLY377B, GLY377E, GLY383B, GLY383E, GLY384B, GLY384E, GLY389B, GLY389E, GLY413B, GLY413E, GLY414B, GLY414E, GLY425B, GLY425E, GLY441B, GLY441E, GLY444B, GLY444E, GLY485B, GLY485E, GLY520B, GLY520E, GLY75B, GLY75E, HIS200B, HIS200E, HIS228B, HIS228E, HIS236B, HIS236E, HIS388B, HIS388E, HIS519B, HIS519E, ILE145B, ILE145E, ILE149B, ILE149E, ILE175B, ILE175E, ILE193B, ILE193E, ILE203B, ILE203E, ILE209B, ILE209E, ILE231B, ILE231E, ILE235B, ILE235E, ILE345B, ILE345E, ILE363B, ILE363E, ILE385B, ILE385E, ILE386B, ILE386E, ILE437B, ILE437E, ILE449B, ILE449E, ILE468B, ILE468E, LEU128B, LEU128E, LEU152B, LEU152E, LEU165B, LEU165E, LEU189B, LEU189E, LEU222B, LEU222E, LEU343B, LEU343E, LEU365E, LEU375B, LEU375E, LEU393B, LEU393E, LEU417B, LEU417E, LEU424B, LEU424E, LEU73B, LEU73E, LYS157B, LYS157E, LYS164B, LYS164E, LYS210B, LYS210E, LYS310B, LYS310E, LYS350B, LYS350E, LYS391B, LYS391E, LYS403B, LYS403E, LYS467B, LYS467E, LYS510B, LYS510E, LYS517B, LYS517E, LYS518B, LYS518E, MET108B, MET108E, MET158B, MET158E, MET195B, MET195E, MET201B, MET201E, MET392B, MET392E, MET440B, MET440E, MET76B, MET76E, PHE159B, PHE159E, PHE160B, PHE160E, PHE192B, PHE192E, PHE202B, PHE202E, PHE354B, PHE354E, PHE357B, PHE357E, PHE361B, PHE361E, PHE374B, PHE374E, PHE450B, PHE450E, PHE475B, PHE475E, PHE522B, PHE522E, PHE74B, PHE74E, PRO170B, PRO170E, PRO187B, PRO187E, PRO206B, PRO206E, PRO376B, PRO376E, PRO402B, PRO402E, PRO478B, PRO478E, PRO515B, PRO515E, PRO523B, PRO523E, SER151B, SER151E, SER153B, SER153E, SER166B, SER166E, SER184B, SER184E, SER186B, SER186E, SER211B, SER211E, SER232B, SER232E, SER348B, SER348E, SER360B, SER360E, SER397B, SER397E, SER415B, SER415E, THR190B, THR190E, THR204B, THR204E, THR213B, THR213E, THR218B, THR218E, THR261B, THR261E, THR400B, THR400E, THR477B, THR477E, THR513B, THR513E, THR71B, THR71E, THR72B, THR72E, TYR155B, TYR155E, TYR185B, TYR185E, TYR313B, TYR313E, TYR382B, TYR382E, TYR394B, TYR394E, TYR396B, TYR396E, TYR412B, TYR412E, TYR416B, TYR416E, TYR471B, TYR471E, TYR479B, TYR479E, VAL121B, VAL121E, VAL163B, VAL163E, VAL168B, VAL168E, VAL169B, VAL169E, VAL208B, VAL208E, VAL212B, VAL212E, VAL217B, VAL217E, VAL355B, VAL355E, VAL378B, VAL378E, VAL401B, VAL401E, VAL439B, VAL439E, VAL448B, VAL448E, VAL480B, VAL480E, VAL487B, VAL487E
• B-F: ALA516B, ARG511F, PRO515F, THR513B, THR513F
• C-D: ALA516C, ALA516D, ARG511D, ARG514C, ARG514D, PRO515C, PRO515D, THR513C, THR513D
• C-E: ARG67C, ARG67E, ARG70C, ARG70E, ASN6E, ASP150C, ASP150E, ASP77C, ASP77E, GLU114C, GLU114E, GLU147C, GLU147E, HIS69C, HIS69E, ILE149C, ILE149E, LEU73C, LEU73E, LYS157C, LYS157E, SER151C, SER151E, SER153C, SER153E, THR115C, THR115E, THR118C, THR118E, THR71C, THR71E, THR72C, THR72E
• C-F: ALA112C, ALA112F, ALA143C, ALA143F, ALA161C, ALA161F, ALA180C, ALA180F, ALA183C, ALA183F, ALA188C, ALA188F, ALA219C, ALA219F, ALA227C, ALA227F, ALA230C, ALA230F, ALA314C, ALA314F, ALA351C, ALA351F, ALA352C, ALA352F, ALA390C, ALA390F, ALA395C, ALA395F, ALA399C, ALA399F, ALA411C, ALA411F, ALA418C, ALA418F, ALA426C, ALA426F, ALA438C, ALA438F, ALA442C, ALA442F, ALA445C, ALA445F, ALA446C, ALA446F, ALA474C, ALA474F, ALA481C, ALA481F, ALA482C, ALA482F, ALA483C, ALA483F, ALA516C, ALA516F, ARG144C, ARG144F, ARG387C, ARG387F, ARG422C, ARG422F, ARG451F, ARG484C, ARG484F, ARG514C, ARG514F, ARG70C, ARG70F, ASN162C, ASN162F, ASN234C, ASN234F, ASN260C, ASN260F, ASN346C, ASN346F, ASN356C, ASN356F, ASN362C, ASN362F, ASN421C, ASN421F, ASN447C, ASN447F, ASN473C, ASN473F, ASN476C, ASN476F, ASN521C, ASN521F, ASP150C, ASP150F, ASP191C, ASP191F, ASP216C, ASP216F, ASP220C, ASP220F, ASP344C, ASP344F, ASP349C, ASP349F, ASP359C, ASP359F, ASP423C, ASP423F, CYS179C, CYS179F, CYS342C, CYS342F, CYS358C, CYS358F, CYS420C, CYS420F, CYS524C, CYS524F, GLN146C, GLN146F, GLN171C, GLN171F, GLN207C, GLN207F, GLN379C, GLN379F, GLN380C, GLN380F, GLN472C, GLN472F, GLN486C, GLN486F, GLN512C, GLN512F, GLU114C, GLU114F, GLU125C, GLU125F, GLU147C, GLU147F, GLU215C, GLU215F, GLU221C, GLU221F, GLU353C, GLU353F, GLU381C, GLU381F, GLU398C, GLU398F, GLU436C, GLU436F, GLU466C, GLU466F, GLU469C, GLU469F, GLU470C, GLU470F, GLY141C, GLY142C, GLY142F, GLY148C, GLY148F, GLY154C, GLY154F, GLY156C, GLY156F, GLY167C, GLY167F, GLY181C, GLY181F, GLY182C, GLY182F, GLY205C, GLY205F, GLY214C, GLY214F, GLY223C, GLY223F, GLY224C, GLY224F, GLY233C, GLY233F, GLY373C, GLY373F, GLY377C, GLY377F, GLY383C, GLY383F, GLY384C, GLY384F, GLY389C, GLY389F, GLY413C, GLY413F, GLY414C, GLY414F, GLY425C, GLY425F, GLY441C, GLY441F, GLY444C, GLY444F, GLY485C, GLY485F, GLY520C, GLY520F, GLY75C, GLY75F, HIS200C, HIS200F, HIS228C, HIS228F, HIS236C, HIS236F, HIS388C, HIS388F, HIS519C, HIS519F, ILE145C, ILE145F, ILE149C, ILE149F, ILE175C, ILE175F, ILE193C, ILE193F, ILE203C, ILE203F, ILE209C, ILE209F, ILE231C, ILE231F, ILE235C, ILE235F, ILE345C, ILE345F, ILE363C, ILE363F, ILE385C, ILE385F, ILE386C, ILE386F, ILE437C, ILE437F, ILE449C, ILE449F, ILE468C, ILE468F, LEU128C, LEU128F, LEU129F, LEU152C, LEU152F, LEU165C, LEU165F, LEU189C, LEU189F, LEU222C, LEU222F, LEU343C, LEU343F, LEU365C, LEU365F, LEU375C, LEU375F, LEU393C, LEU393F, LEU417C, LEU417F, LEU424C, LEU424F, LEU73C, LEU73F, LYS157C, LYS157F, LYS164C, LYS164F, LYS210C, LYS210F, LYS310C, LYS310F, LYS350C, LYS350F, LYS391C, LYS391F, LYS403C, LYS403F, LYS452F, LYS467C, LYS467F, LYS510C, LYS510F, LYS517C, LYS517F, LYS518C, LYS518F, MET108C, MET158C, MET158F, MET195C, MET195F, MET201C, MET201F, MET392C, MET392F, MET440C, MET440F, MET76C, MET76F, PHE159C, PHE159F, PHE160C, PHE160F, PHE192C, PHE192F, PHE202C, PHE202F, PHE354C, PHE354F, PHE357C, PHE357F, PHE361C, PHE361F, PHE374C, PHE374F, PHE450F, PHE475C, PHE475F, PHE522C, PHE522F, PHE74C, PHE74F, PRO170C, PRO170F, PRO187C, PRO187F, PRO206C, PRO206F, PRO376C, PRO376F, PRO402C, PRO402F, PRO478C, PRO478F, PRO515C, PRO515F, PRO523C, PRO523F, SER151C, SER151F, SER153C, SER153F, SER166C, SER166F, SER184C, SER184F, SER186C, SER186F, SER211C, SER211F, SER232C, SER232F, SER340F, SER348C, SER348F, SER360C, SER360F, SER397C, SER397F, SER415C, SER415F, THR190C, THR190F, THR204C, THR204F, THR213C, THR213F, THR218C, THR218F, THR261C, THR261F, THR400C, THR400F, THR477C, THR477F, THR513C, THR513F, THR71C, THR71F, THR72C, THR72F, TYR155C, TYR155F, TYR185C, TYR185F, TYR313C, TYR313F, TYR382C, TYR382F, TYR394C, TYR394F, TYR396C, TYR396F, TYR412C, TYR412F, TYR416C, TYR416F, TYR471C, TYR471F, TYR479C, TYR479F, VAL121C, VAL121F, VAL163C, VAL163F, VAL168C, VAL168F, VAL169C, VAL169F, VAL208C, VAL208F, VAL212C, VAL212F, VAL217C, VAL217F, VAL355C, VAL355F, VAL378C, VAL378F, VAL401C, VAL401F, VAL439C, VAL439F, VAL448C, VAL448F, VAL480C, VAL480F, VAL487C, VAL487F
• D-E: ALA100D, ALA10D, ALA127D, ALA21D, ALA426E, ALA428E, ALA431E, ALA435E, ALA474E, ALA481E, ALA482E, ALA483E, ALA494E, ALA501E, ALA503E, ALA508E, ALA65D, ALA83D, ARG16D, ARG24D, ARG280E, ARG327E, ARG409E, ARG422E, ARG484E, ARG498E, ARG511E, ARG67D, ARG70D, ARG90D, ASN259D, ASN473E, ASN476E, ASP281E, ASP286E, ASP427E, ASP488E, ASP489E, ASP492E, ASP495E, ASP61D, ASP84D, GLN126D, GLN19D, GLN23D, GLN258D, GLN472E, GLN486E, GLN512E, GLU122D, GLU125D, GLU14D, GLU18D, GLU22D, GLU262D, GLU278E, GLU436E, GLU469E, GLU505E, GLU62D, GLY131D, GLY15D, GLY287E, GLY425E, GLY485E, GLY64D, GLY89D, GLY91D, GLY95D, HIS58D, HIS69D, HIS99D, ILE27D, ILE282E, ILE285E, ILE491E, LEU128D, LEU129D, LEU20D, LEU279E, LEU408E, LEU504E, LEU7D, LEU9D, LYS119D, LYS403E, LYS499E, LYS510E, LYS68D, LYS8D, MET13D, MET506E, PHE475E, PHE60D, PHE66D, PRO284E, PRO402E, PRO433E, PRO478E, PRO493E, PRO97D, SER11D, SER434E, SER502E, SER59D, THR115D, THR118D, THR123D, THR12D, THR130D, THR132D, THR261D, THR277E, THR400E, THR477E, THR509E, THR513E, THR72D, THR92D, TRP432E, TYR430E, TYR479E, TYR507E, VAL17D, VAL283E, VAL401E, VAL429E, VAL480E, VAL487E, VAL490E, VAL63D, VAL98D
• D-F: ALA100F, ALA10F, ALA127F, ALA21F, ALA426D, ALA428D, ALA431D, ALA435D, ALA481D, ALA482D, ALA483D, ALA494D, ALA501D, ALA503D, ALA508D, ALA65F, ALA83F, ARG16F, ARG24F, ARG280D, ARG409D, ARG422D, ARG484D, ARG498D, ARG511D, ARG67F, ARG70F, ARG90F, ARG96F, ASN259F, ASN260F, ASN473D, ASN476D, ASP281D, ASP286D, ASP427D, ASP488D, ASP489D, ASP492D, ASP495D, ASP61F, GLN126F, GLN19F, GLN23F, GLN258F, GLN472D, GLN486D, GLN512D, GLU122F, GLU125F, GLU14F, GLU18F, GLU22F, GLU262F, GLU278D, GLU436D, GLU505D, GLU62F, GLY131F, GLY15F, GLY287D, GLY425D, GLY485D, GLY64F, GLY89F, GLY91F, GLY95F, HIS58F, HIS69F, HIS99F, ILE27F, ILE282D, ILE285D, ILE404D, ILE491D, ILE500D, LEU128F, LEU129F, LEU165F, LEU20F, LEU279D, LEU408D, LEU504D, LEU9F, LYS119F, LYS164F, LYS403D, LYS499D, LYS510D, LYS68F, MET13F, MET506D, PHE475D, PHE60F, PHE66F, PRO133F, PRO284D, PRO402D, PRO433D, PRO478D, PRO493D, PRO97F, SER11F, SER434D, SER502D, SER59F, THR115F, THR118F, THR123F, THR12F, THR130F, THR132F, THR261F, THR277D, THR400D, THR477D, THR509D, THR513D, THR88F, THR92F, TRP432D, TYR430D, TYR479D, TYR507D, VAL168F, VAL169F, VAL17F, VAL283D, VAL401D, VAL429D, VAL480D, VAL487D, VAL490D, VAL63F, VAL98F
• E-F: ALA10E, ALA127E, ALA21E, ALA426F, ALA428F, ALA431F, ALA435F, ALA474F, ALA481F, ALA482F, ALA483F, ALA494F, ALA501F, ALA503F, ALA508F, ALA65E, ALA83E, ARG16E, ARG24E, ARG280F, ARG327F, ARG409F, ARG422F, ARG484F, ARG498F, ARG511F, ARG67E, ARG70E, ARG90E, ASN259E, ASN473F, ASN476F, ASN6E, ASP281F, ASP286F, ASP427F, ASP488F, ASP489F, ASP492F, ASP495F, ASP61E, ASP84E, GLN126E, GLN19E, GLN23E, GLN258E, GLN472F, GLN486F, GLN512F, GLU122E, GLU125E, GLU14E, GLU18E, GLU22E, GLU262E, GLU436F, GLU469F, GLU470F, GLU505F, GLU62E, GLY131E, GLY15E, GLY287F, GLY425F, GLY485F, GLY64E, GLY89E, GLY91E, GLY95E, HIS58E, HIS69E, HIS99E, ILE27E, ILE282F, ILE285F, ILE491F, LEU128E, LEU129E, LEU20E, LEU279F, LEU408F, LEU504F, LEU7E, LEU9E, LYS119E, LYS403F, LYS499F, LYS510F, LYS68E, LYS8E, MET13E, MET506F, PHE475F, PHE60E, PHE66E, PRO284F, PRO402F, PRO433F, PRO478F, PRO493F, PRO97E, SER11E, SER434F, SER502F, SER59E, THR115E, THR118E, THR123E, THR12E, THR130E, THR132E, THR261E, THR277F, THR400F, THR477F, THR509F, THR513F, THR92E, TRP432F, TYR430F, TYR471F, TYR479F, TYR507F, VAL17E, VAL283F, VAL401F, VAL429F, VAL480F, VAL487F, VAL490F, VAL63E, VAL98E