1OJX

crystal structure of an archaeal fructose 1,6-bisphosphate aldolase

• Total interactions analyzed: 45
• Total true interactions: 21
• Strongest Interaction:
  • Chains: H-I
  • Int. Res.: 135
  • Norm. En. per Res.: -4.2259
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-94.653	-45.8041	-417.294	-557.7511	136	16	6	16885	5	54	43
A-E	-91.1357	-53.289	-426.251	-570.6757	137	12	6	17056	6	55	43
A-F	0.0	-15.0431	-52.9866	-68.0297	39	0	1	2182	0	14	17
A-J	0.0	0.0	-0.0484	-0.0484	4	0	0	29	0	0	3
B-C	-75.235	-54.8294	-418.682	-548.7464	139	13	6	17201	6	55	44
B-F	0.0	0.0	-0.0893	-0.0893	4	0	0	43	0	0	3
B-G	0.0	-15.1344	-55.2883	-70.4227	47	0	3	2348	0	16	17
B-H	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	0	2
C-D	-82.714	-47.4396	-418.603	-548.7566	135	13	7	16887	5	54	43
C-G	0.0	0.0	-0.0883	-0.0883	4	0	0	37	0	0	3
C-H	0.0	-15.4054	-57.7801	-73.1855	48	0	1	2386	0	16	18
D-E	-78.4194	-48.9919	-423.164	-550.5753	137	14	7	17250	5	55	43
D-H	0.0	0.0	-0.0812	-0.0812	4	0	0	41	0	0	3
D-I	0.0	-14.2184	-52.8753	-67.0937	43	0	1	2268	0	15	17
E-I	0.0	0.0	-0.0676	-0.0676	4	0	0	35	0	0	3
E-J	0.0	-14.8195	-52.0383	-66.8578	41	0	1	2161	0	14	17
F-G	-82.1555	-48.5436	-410.753	-541.4521	135	13	7	16755	5	55	43
F-J	-84.5067	-48.4729	-419.871	-552.8506	137	12	6	17176	4	55	43
G-H	-82.7576	-43.9275	-425.589	-552.2741	138	14	6	17358	5	55	44
H-I	-97.8059	-51.618	-421.066	-570.49	135	15	7	17114	5	54	42
I-J	-99.273	-50.8012	-423.229	-573.3032	136	13	6	17202	6	54	42

Interface residues

• A-B: ALA101A, ALA128B, ALA134B, ALA162B, ALA164B, ALA165B, ALA168B, ALA173B, ALA175B, ALA190B, ALA194B, ALA32A, ALA41A, ALA65A, ALA94A, ARG129A, ARG129B, ARG132B, ARG148B, ARG166B, ARG62A, ASN37A, ASN3B, ASN80A, ASN87A, ASN95A, ASP133A, ASP133B, ASP174B, ASP24A, ASP33A, ASP36A, ASP39A, ASP42A, CYS96A, GLN61A, GLU100A, GLU120B, GLU125B, GLU126A, GLU126B, GLU159B, GLU170B, GLU28A, GLU44A, GLU66A, GLU6B, GLU89A, GLU89B, GLU99A, GLY116B, GLY118B, GLY149B, GLY150B, GLY172B, GLY195B, GLY26A, GLY30A, GLY63A, GLY81A, GLY88A, HIS25A, HIS29A, ILE113B, ILE130B, ILE160B, ILE167B, ILE27A, ILE46A, ILE64A, LEU104A, LEU127B, LEU141B, LEU169B, LEU171B, LEU4B, LEU77A, LEU79A, LEU85A, LYS122A, LYS122B, LYS131B, LYS136A, LYS136B, LYS151B, LYS185B, LYS192B, LYS196B, LYS67A, LYS78A, LYS82A, MET123B, MET176B, MET35A, PHE119A, PHE119B, PHE124B, PHE137A, PHE34A, PHE60A, PRO115B, PRO140B, PRO147B, PRO158B, PRO198B, PRO31A, PRO38A, PRO43A, SER103A, SER117B, SER40A, SER92A, SER97A, THR186B, THR5B, THR83A, THR84A, TRP121A, TRP121B, TRP189B, TYR114B, TYR146B, TYR163B, TYR23A, TYR68A, TYR69A, TYR86A, VAL135B, VAL152B, VAL153B, VAL161B, VAL193B, VAL197B, VAL91A, VAL93A, VAL98A
• A-E: ALA101E, ALA128A, ALA134A, ALA162A, ALA164A, ALA165A, ALA168A, ALA173A, ALA175A, ALA190A, ALA194A, ALA32E, ALA41E, ALA65E, ALA94E, ARG129A, ARG129E, ARG132A, ARG148A, ARG166A, ARG62E, ASN154A, ASN37E, ASN3A, ASN80E, ASN87E, ASN95E, ASP133A, ASP133E, ASP174A, ASP24E, ASP33E, ASP36E, ASP39E, ASP42E, CYS96E, GLN61E, GLU100E, GLU120A, GLU125A, GLU126A, GLU126E, GLU159A, GLU170A, GLU28E, GLU44E, GLU66E, GLU6A, GLU89A, GLU89E, GLU99E, GLY116A, GLY118A, GLY149A, GLY150A, GLY172A, GLY195A, GLY26E, GLY30E, GLY63E, GLY81E, GLY88E, HIS25E, HIS29E, ILE113A, ILE130A, ILE160A, ILE167A, ILE27E, ILE46E, ILE64E, LEU104E, LEU127A, LEU141A, LEU169A, LEU171A, LEU4A, LEU77E, LEU79E, LEU85E, LYS122A, LYS122E, LYS131A, LYS136A, LYS136E, LYS151A, LYS185A, LYS192A, LYS196A, LYS67E, LYS78E, LYS82E, MET123A, MET176A, MET35E, PHE119A, PHE119E, PHE124A, PHE137E, PHE34E, PHE60E, PRO115A, PRO140A, PRO147A, PRO158A, PRO198A, PRO31E, PRO38E, PRO43E, SER103E, SER117A, SER40E, SER92E, SER97E, THR186A, THR5A, THR83E, THR84E, TRP121A, TRP121E, TRP189A, TYR114A, TYR146A, TYR163A, TYR23E, TYR68E, TYR69E, TYR86E, VAL135A, VAL152A, VAL153A, VAL161A, VAL193A, VAL197A, VAL91E, VAL93E, VAL98E
• A-F: ALA106A, ALA106F, ALA134A, ALA134F, ARG10A, ARG10F, ASN3F, ASP133A, ASP133F, ASP138A, ASP138F, GLU100A, GLU100F, GLU99A, GLU99F, GLY105A, GLY105F, ILE11A, ILE11F, LEU139A, LEU139F, LEU4A, LEU4F, LYS136A, LYS136F, LYS7A, LYS7F, PHE137A, PHE137F, SER103A, SER103F, SER107A, SER107F, VAL102A, VAL102F, VAL135A, VAL135F, VAL98A, VAL98F
• A-J: ARG132A, ARG132J, LYS136A, LYS136J
• B-C: ALA101B, ALA128C, ALA134C, ALA162C, ALA164C, ALA165C, ALA168C, ALA173C, ALA175C, ALA190C, ALA194C, ALA32B, ALA41B, ALA65B, ALA94B, ARG129B, ARG129C, ARG132C, ARG148C, ARG166C, ARG62B, ASN154C, ASN37B, ASN3C, ASN80B, ASN87B, ASN95B, ASP133B, ASP133C, ASP174C, ASP24B, ASP33B, ASP36B, ASP39B, ASP42B, CYS96B, GLN61B, GLU100B, GLU120C, GLU125C, GLU126B, GLU126C, GLU155C, GLU159C, GLU170C, GLU28B, GLU44B, GLU66B, GLU6C, GLU89B, GLU89C, GLU99B, GLY116C, GLY118C, GLY149C, GLY150C, GLY172C, GLY195C, GLY26B, GLY30B, GLY63B, GLY81B, GLY88B, HIS25B, HIS29B, ILE113C, ILE130C, ILE160C, ILE167C, ILE27B, ILE46B, ILE64B, LEU104B, LEU127C, LEU141C, LEU169C, LEU171C, LEU4C, LEU77B, LEU79B, LEU85B, LYS122B, LYS122C, LYS131C, LYS136B, LYS136C, LYS151C, LYS185C, LYS192C, LYS196C, LYS67B, LYS78B, LYS82B, MET123C, MET176C, MET35B, PHE119B, PHE119C, PHE124C, PHE137B, PHE34B, PHE60B, PRO115C, PRO140C, PRO147C, PRO158C, PRO198C, PRO31B, PRO38B, PRO43B, SER103B, SER117C, SER40B, SER92B, SER97B, THR186C, THR5C, THR83B, THR84B, TRP121B, TRP121C, TRP189C, TYR114C, TYR146C, TYR163C, TYR23B, TYR45B, TYR68B, TYR69B, TYR86B, VAL135C, VAL152C, VAL153C, VAL161C, VAL193C, VAL197C, VAL91B, VAL93B, VAL98B
• B-F: ARG132B, ARG132F, LYS136B, LYS136F
• B-G: ALA101B, ALA101G, ALA106B, ALA106G, ALA134B, ALA134G, ARG10B, ARG10G, ASN3G, ASP133B, ASP133G, ASP138B, ASP138G, GLU100B, GLU100G, GLU99B, GLU99G, GLY105B, GLY105G, GLY71B, GLY71G, ILE11B, ILE11G, LEU104B, LEU104G, LEU139B, LEU139G, LEU4B, LEU4G, LYS136B, LYS136G, LYS7B, LYS7G, PHE137B, PHE137G, PRO74B, PRO74G, SER103B, SER103G, SER107B, SER107G, VAL102B, VAL102G, VAL135B, VAL135G, VAL98B, VAL98G
• B-H: SER103B, SER103H
• C-D: ALA101C, ALA128D, ALA134D, ALA162D, ALA164D, ALA165D, ALA168D, ALA173D, ALA175D, ALA190D, ALA194D, ALA32C, ALA41C, ALA65C, ALA94C, ARG129C, ARG129D, ARG132D, ARG148D, ARG166D, ARG62C, ASN37C, ASN3D, ASN80C, ASN87C, ASN95C, ASP133C, ASP133D, ASP174D, ASP24C, ASP33C, ASP36C, ASP39C, ASP42C, CYS96C, GLN61C, GLU100C, GLU120D, GLU125D, GLU126C, GLU126D, GLU159D, GLU170D, GLU28C, GLU44C, GLU66C, GLU6D, GLU89C, GLU89D, GLU99C, GLY116D, GLY118D, GLY149D, GLY150D, GLY172D, GLY195D, GLY26C, GLY30C, GLY63C, GLY81C, GLY88C, HIS25C, HIS29C, ILE113D, ILE130D, ILE160D, ILE167D, ILE27C, ILE46C, ILE64C, LEU104C, LEU127D, LEU141D, LEU169D, LEU171D, LEU4D, LEU77C, LEU79C, LEU85C, LYS122C, LYS122D, LYS131D, LYS136C, LYS136D, LYS151D, LYS185D, LYS192D, LYS196D, LYS67C, LYS78C, LYS82C, MET123D, MET35C, PHE119C, PHE119D, PHE124D, PHE137C, PHE34C, PHE60C, PRO115D, PRO140D, PRO147D, PRO158D, PRO198D, PRO31C, PRO38C, PRO43C, SER103C, SER117D, SER40C, SER92C, SER97C, THR186D, THR5D, THR83C, THR84C, TRP121C, TRP121D, TRP189D, TYR114D, TYR146D, TYR163D, TYR23C, TYR68C, TYR69C, TYR86C, VAL135D, VAL152D, VAL153D, VAL161D, VAL193D, VAL197D, VAL91C, VAL93C, VAL98C
• C-G: ARG132C, ARG132G, LYS136C, LYS136G
• C-H: ALA101C, ALA101H, ALA106C, ALA106H, ALA134C, ALA134H, ARG10C, ARG10H, ASN3C, ASN3H, ASP133C, ASP133H, ASP138C, ASP138H, GLU100C, GLU100H, GLU6C, GLU99C, GLU99H, GLY105C, GLY105H, GLY71C, GLY71H, ILE11C, ILE11H, LEU104H, LEU139C, LEU139H, LEU4C, LEU4H, LYS136C, LYS136H, LYS7C, LYS7H, PHE137C, PHE137H, PRO74C, PRO74H, SER103C, SER103H, SER107C, SER107H, VAL102C, VAL102H, VAL135C, VAL135H, VAL98C, VAL98H
• D-E: ALA101D, ALA128E, ALA134E, ALA162E, ALA164E, ALA165E, ALA168E, ALA173E, ALA175E, ALA190E, ALA194E, ALA32D, ALA41D, ALA65D, ALA94D, ARG129D, ARG129E, ARG132E, ARG148E, ARG166E, ARG62D, ASN154E, ASN37D, ASN3E, ASN80D, ASN87D, ASN95D, ASP133D, ASP133E, ASP174E, ASP24D, ASP33D, ASP36D, ASP39D, ASP42D, CYS96D, GLN61D, GLU100D, GLU120E, GLU125E, GLU126D, GLU126E, GLU159E, GLU170E, GLU28D, GLU44D, GLU66D, GLU6E, GLU89D, GLU89E, GLU99D, GLY116E, GLY118E, GLY149E, GLY150E, GLY172E, GLY195E, GLY26D, GLY30D, GLY63D, GLY81D, GLY88D, HIS25D, HIS29D, ILE113E, ILE130E, ILE160E, ILE167E, ILE27D, ILE46D, ILE64D, LEU104D, LEU127E, LEU141E, LEU169E, LEU171E, LEU4E, LEU77D, LEU79D, LEU85D, LYS122D, LYS122E, LYS131E, LYS136D, LYS136E, LYS151E, LYS185E, LYS192E, LYS196E, LYS67D, LYS78D, LYS82D, MET123E, MET35D, PHE119D, PHE119E, PHE124E, PHE137D, PHE34D, PHE60D, PRO115E, PRO140E, PRO147E, PRO158E, PRO198E, PRO31D, PRO38D, PRO43D, SER103D, SER117E, SER40D, SER92D, SER97D, THR186E, THR5E, THR83D, THR84D, TRP121D, TRP121E, TRP189E, TYR114E, TYR146E, TYR163E, TYR23D, TYR45D, TYR68D, TYR69D, TYR86D, VAL135E, VAL152E, VAL153E, VAL161E, VAL193E, VAL197E, VAL91D, VAL93D, VAL98D
• D-H: ARG132D, ARG132H, LYS136D, LYS136H
• D-I: ALA106D, ALA106I, ALA134D, ALA134I, ARG10D, ARG10I, ASN3D, ASN3I, ASP133D, ASP133I, ASP138D, ASP138I, GLU100D, GLU100I, GLU99D, GLU99I, GLY105D, GLY105I, GLY71I, ILE11D, ILE11I, LEU139D, LEU139I, LEU4D, LEU4I, LYS136D, LYS136I, LYS7D, LYS7I, PHE137D, PHE137I, PRO74D, PRO74I, SER103D, SER103I, SER107D, SER107I, VAL102D, VAL102I, VAL135D, VAL135I, VAL98D, VAL98I
• E-I: ARG132E, ARG132I, LYS136E, LYS136I
• E-J: ALA106E, ALA106J, ALA134E, ALA134J, ARG10E, ARG10J, ARG132J, ASN3E, ASN3J, ASP133E, ASP133J, ASP138E, ASP138J, GLU100E, GLU100J, GLU99E, GLU99J, GLY105E, GLY105J, ILE11E, ILE11J, LEU139E, LEU139J, LEU4E, LEU4J, LYS136E, LYS136J, LYS7E, LYS7J, PHE137E, PHE137J, SER103E, SER103J, SER107E, SER107J, VAL102E, VAL102J, VAL135E, VAL135J, VAL98E, VAL98J
• F-G: ALA101G, ALA128F, ALA134F, ALA162F, ALA164F, ALA165F, ALA168F, ALA173F, ALA175F, ALA190F, ALA194F, ALA32G, ALA41G, ALA65G, ALA94G, ARG129F, ARG129G, ARG132F, ARG148F, ARG166F, ARG62G, ASN37G, ASN3F, ASN80G, ASN87G, ASN95G, ASP133F, ASP133G, ASP174F, ASP24G, ASP33G, ASP36G, ASP39G, ASP42G, CYS96G, GLN61G, GLU100G, GLU120F, GLU125F, GLU126F, GLU126G, GLU159F, GLU170F, GLU28G, GLU44G, GLU66G, GLU6F, GLU89F, GLU89G, GLU99G, GLY116F, GLY118F, GLY149F, GLY150F, GLY172F, GLY195F, GLY26G, GLY30G, GLY63G, GLY81G, GLY88G, HIS25G, HIS29G, ILE113F, ILE130F, ILE160F, ILE167F, ILE27G, ILE46G, ILE64G, LEU104G, LEU127F, LEU141F, LEU169F, LEU171F, LEU4F, LEU77G, LEU79G, LEU85G, LYS122F, LYS122G, LYS131F, LYS136G, LYS151F, LYS185F, LYS192F, LYS196F, LYS67G, LYS78G, LYS82G, MET123F, MET176F, MET35G, PHE119F, PHE119G, PHE124F, PHE137G, PHE34G, PHE60G, PRO115F, PRO140F, PRO147F, PRO158F, PRO198F, PRO31G, PRO38G, PRO43G, SER103G, SER117F, SER40G, SER92G, SER97G, THR186F, THR5F, THR83G, THR84G, TRP121F, TRP121G, TRP189F, TYR114F, TYR146F, TYR163F, TYR23G, TYR68G, TYR69G, TYR86G, VAL135F, VAL152F, VAL153F, VAL161F, VAL193F, VAL197F, VAL91G, VAL93G, VAL98G
• F-J: ALA101F, ALA128J, ALA134J, ALA162J, ALA164J, ALA165J, ALA168J, ALA173J, ALA175J, ALA190J, ALA194J, ALA32F, ALA41F, ALA65F, ALA94F, ARG129F, ARG129J, ARG132J, ARG148J, ARG166J, ARG62F, ASN154J, ASN37F, ASN3J, ASN80F, ASN87F, ASN95F, ASP133F, ASP133J, ASP174J, ASP24F, ASP33F, ASP36F, ASP39F, ASP42F, CYS96F, GLN61F, GLU100F, GLU120J, GLU125J, GLU126F, GLU126J, GLU159J, GLU170J, GLU28F, GLU44F, GLU66F, GLU6J, GLU89F, GLU89J, GLU99F, GLY116J, GLY118J, GLY149J, GLY150J, GLY172J, GLY195J, GLY26F, GLY30F, GLY63F, GLY81F, GLY88F, HIS25F, HIS29F, ILE113J, ILE130J, ILE160J, ILE167J, ILE27F, ILE46F, ILE64F, LEU104F, LEU127J, LEU141J, LEU169J, LEU171J, LEU4J, LEU77F, LEU79F, LEU85F, LYS122F, LYS122J, LYS131J, LYS136J, LYS151J, LYS185J, LYS192J, LYS196J, LYS67F, LYS78F, LYS82F, MET123J, MET176J, MET35F, PHE119F, PHE119J, PHE124J, PHE137F, PHE34F, PHE60F, PRO115J, PRO140J, PRO147J, PRO158J, PRO198J, PRO31F, PRO38F, PRO43F, SER103F, SER117J, SER40F, SER92F, SER97F, THR186J, THR5J, THR83F, THR84F, TRP121F, TRP121J, TRP189J, TYR114J, TYR146J, TYR163J, TYR23F, TYR45F, TYR68F, TYR69F, TYR86F, VAL135J, VAL152J, VAL153J, VAL161J, VAL193J, VAL197J, VAL91F, VAL93F, VAL98F
• G-H: ALA101H, ALA128G, ALA134G, ALA162G, ALA164G, ALA165G, ALA168G, ALA173G, ALA175G, ALA190G, ALA194G, ALA32H, ALA41H, ALA65H, ALA94H, ARG129G, ARG129H, ARG132G, ARG148G, ARG166G, ARG62H, ASN154G, ASN37H, ASN3G, ASN80H, ASN87H, ASN95H, ASP133G, ASP133H, ASP174G, ASP24H, ASP33H, ASP36H, ASP39H, ASP42H, ASP70H, CYS96H, GLN61H, GLU100H, GLU120G, GLU125G, GLU126G, GLU126H, GLU155G, GLU159G, GLU170G, GLU28H, GLU44H, GLU66H, GLU6G, GLU89G, GLU89H, GLU99H, GLY116G, GLY118G, GLY149G, GLY150G, GLY172G, GLY195G, GLY26H, GLY30H, GLY63H, GLY81H, GLY88H, HIS25H, HIS29H, ILE113G, ILE130G, ILE160G, ILE167G, ILE27H, ILE46H, ILE64H, LEU104H, LEU127G, LEU141G, LEU169G, LEU171G, LEU4G, LEU79H, LEU85H, LYS122G, LYS122H, LYS131G, LYS136G, LYS136H, LYS151G, LYS185G, LYS192G, LYS196G, LYS67H, LYS78H, LYS82H, MET123G, MET35H, PHE119G, PHE119H, PHE124G, PHE137H, PHE34H, PHE60H, PRO115G, PRO140G, PRO147G, PRO158G, PRO198G, PRO31H, PRO38H, PRO43H, SER103H, SER117G, SER40H, SER92H, SER97H, THR186G, THR5G, THR83H, THR84H, TRP121G, TRP121H, TRP189G, TYR114G, TYR146G, TYR163G, TYR23H, TYR45H, TYR68H, TYR69H, TYR86H, VAL135G, VAL152G, VAL153G, VAL161G, VAL193G, VAL197G, VAL91H, VAL93H, VAL98H
• H-I: ALA101I, ALA128H, ALA134H, ALA162H, ALA164H, ALA165H, ALA168H, ALA173H, ALA175H, ALA190H, ALA194H, ALA32I, ALA41I, ALA65I, ALA94I, ARG129H, ARG129I, ARG132H, ARG148H, ARG166H, ARG62I, ASN37I, ASN3H, ASN80I, ASN87I, ASN95I, ASP133H, ASP133I, ASP174H, ASP24I, ASP33I, ASP36I, ASP39I, ASP42I, CYS96I, GLN61I, GLU100I, GLU120H, GLU125H, GLU126H, GLU126I, GLU159H, GLU170H, GLU28I, GLU44I, GLU66I, GLU6H, GLU89H, GLU89I, GLU99I, GLY116H, GLY118H, GLY149H, GLY150H, GLY172H, GLY195H, GLY26I, GLY30I, GLY63I, GLY81I, GLY88I, HIS25I, HIS29I, ILE113H, ILE130H, ILE160H, ILE167H, ILE27I, ILE46I, ILE64I, LEU104I, LEU127H, LEU141H, LEU169H, LEU171H, LEU4H, LEU79I, LEU85I, LYS122H, LYS122I, LYS131H, LYS136H, LYS136I, LYS151H, LYS185H, LYS192H, LYS196H, LYS67I, LYS78I, LYS82I, MET123H, MET35I, PHE119H, PHE119I, PHE124H, PHE137I, PHE34I, PHE60I, PRO115H, PRO140H, PRO147H, PRO158H, PRO198H, PRO31I, PRO38I, PRO43I, SER103I, SER117H, SER40I, SER92I, SER97I, THR186H, THR5H, THR83I, THR84I, TRP121H, TRP121I, TRP189H, TYR114H, TYR146H, TYR163H, TYR23I, TYR45I, TYR68I, TYR69I, TYR86I, VAL135H, VAL152H, VAL153H, VAL161H, VAL193H, VAL197H, VAL91I, VAL93I, VAL98I
• I-J: ALA101J, ALA128I, ALA134I, ALA162I, ALA164I, ALA165I, ALA168I, ALA173I, ALA175I, ALA190I, ALA194I, ALA32J, ALA41J, ALA65J, ALA94J, ARG129I, ARG129J, ARG132I, ARG148I, ARG166I, ARG62J, ASN154I, ASN37J, ASN3I, ASN80J, ASN87J, ASN95J, ASP133I, ASP133J, ASP174I, ASP24J, ASP33J, ASP36J, ASP39J, ASP42J, CYS96J, GLN61J, GLU100J, GLU120I, GLU125I, GLU126I, GLU126J, GLU159I, GLU170I, GLU28J, GLU44J, GLU66J, GLU6I, GLU89I, GLU89J, GLU99J, GLY116I, GLY118I, GLY149I, GLY150I, GLY172I, GLY195I, GLY26J, GLY30J, GLY63J, GLY81J, GLY88J, HIS25J, HIS29J, ILE113I, ILE130I, ILE160I, ILE167I, ILE27J, ILE46J, ILE64J, LEU104J, LEU127I, LEU141I, LEU169I, LEU171I, LEU4I, LEU79J, LEU85J, LYS122I, LYS122J, LYS131I, LYS136I, LYS136J, LYS151I, LYS185I, LYS192I, LYS196I, LYS67J, LYS78J, LYS82J, MET123I, MET35J, PHE119I, PHE119J, PHE124I, PHE137J, PHE34J, PHE60J, PRO115I, PRO140I, PRO147I, PRO158I, PRO198I, PRO31J, PRO38J, PRO43J, SER103J, SER117I, SER40J, SER92J, SER97J, THR186I, THR5I, THR83J, THR84J, TRP121I, TRP121J, TRP189I, TYR114I, TYR146I, TYR163I, TYR23J, TYR45J, TYR68J, TYR69J, TYR86J, VAL135I, VAL152I, VAL153I, VAL161I, VAL193I, VAL197I, VAL91J, VAL93J, VAL98J