1OGY

crystal structure of the heterodimeric nitrate reductase from rhodobacter sphaeroides

• Total interactions analyzed: 120
• Total true interactions: 51
• Strongest Interaction:
  • Chains: C-D
  • Int. Res.: 245
  • Norm. En. per Res.: -4.1931
• Hub Node: A(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-116.6386	-76.2084	-829.102	-1021.949	245	63	18	33101	7	67	67
A-E	0.0	0.0	-0.7214	-0.7214	6	0	0	107	0	1	3
A-F	-13.3791	1.1639	-68.7792	-80.9944	34	3	1	2293	0	11	6
A-G	0.0	16.2517	-9.1219	7.1298	20	0	0	404	3	15	13
A-H	-8.0583	8.4752	-24.9205	-24.5036	25	2	0	1356	0	9	8
A-O	0.0	13.1683	0.0	13.1683	3	0	0	0	0	0	0
B-D	-4.1398	0.0	-41.0836	-45.2234	22	4	0	1411	0	4	0
B-E	-12.5854	1.1708	-72.351	-83.7656	33	4	1	2364	0	11	6
B-F	-16.7928	37.8553	-256.1	-235.0375	91	5	4	10784	0	10	15
B-H	0.0	0.0	-30.9503	-30.9503	30	4	0	1837	0	3	5
B-O	-13.6059	14.0165	0.0	0.4106	4	0	0	0	0	0	0
C-D	-130.5585	-73.0432	-823.696	-1027.2977	245	65	17	32980	7	67	67
C-E	0.0	13.9945	-7.6371	6.3574	14	0	0	329	3	13	11
C-F	0.0	10.2525	-15.0964	-4.8439	18	0	0	1002	0	9	6
C-G	0.0	0.0	-0.5767	-0.5767	4	0	0	91	0	1	3
C-H	0.0	1.1544	-69.1871	-68.0327	34	5	1	2343	0	12	6
C-M	0.0	14.8124	-5.7802	9.0322	19	0	0	313	2	13	10
D-F	0.0	0.0	-33.8768	-33.8768	28	4	0	1707	0	4	6
D-G	0.0	1.1584	-68.6297	-67.4713	34	3	1	2286	0	11	6
D-H	-15.7198	36.9453	-252.459	-231.2335	91	6	4	10562	0	10	15
D-M	-11.1004	9.6154	-22.6419	-24.1269	21	3	0	1192	0	9	8
D-N	0.0	0.0	-34.2172	-34.2172	30	4	0	1810	0	5	5
E-F	-105.7364	-75.1699	-833.211	-1014.1173	245	61	17	33100	6	67	67
E-I	0.0	12.9296	-3.3557	9.5738	16	0	0	212	1	13	10
E-J	-10.9881	13.1559	-18.0558	-15.8881	20	1	0	1069	0	9	7
F-J	-9.7415	0.0	-33.8101	-43.5516	29	3	0	1723	0	5	5
F-P	-4.0585	0.0			2
G-H	-103.9515	-74.228	-814.297	-992.4764	246	69	17	33152	6	67	68
G-K	0.0	13.4708	-3.5851	9.8857	19	0	0	264	1	13	12
G-L	-12.4747	10.773	-24.704	-26.4058	23	3	0	1259	0	9	9
H-L	-10.078	0.0	-34.7595	-44.8375	29	5	0	1816	0	5	5
H-N	-14.1731	0.0	-43.0575	-57.2306	22	1	0	1468	0	4	0
I-J	-116.8348	-74.1115	-815.988	-1006.9343	247	71	17	33057	6	68	67
I-M	0.0	13.289	-3.7843	9.5047	17	0	0	231	1	13	9
I-N	-12.4188	13.4115	-18.6131	-17.6204	20	1	0	1066	0	9	7
I-O	0.0	0.0	-0.2954	-0.2954	5	0	0	66	0	0	1
I-P	0.0	1.0963			2
J-L	-14.2714	0.0	-43.4492	-57.7206	23	1	0	1470	0	4	0
J-N	-8.3216	0.0	-35.5655	-43.8871	29	3	0	1703	0	4	5
J-O	0.0	0.0	-56.0029	-56.0029	30	1	1	1989	0	10	4
J-P	-15.2724	37.292			6
K-L	-104.9547	-73.2037	-808.754	-986.9124	247	69	18	32933	7	67	68
K-M	0.0	0.0	-0.4938	-0.4938	6	0	0	89	0	0	3
K-N	0.0	1.1405	-68.4685	-67.328	37	4	1	2328	0	11	6
K-O	0.0	14.794	-5.275	9.5189	7	0	0	281	2	9	4
K-P	-10.9542	10.2409			5
L-M	0.0	1.107	-63.2288	-62.1219	33	3	1	2210	0	11	6
L-N	-15.5305	39.7921	-261.813	-237.5515	92	6	5	10885	0	10	15
L-P	-8.9532	0.0			2
M-N	-111.9034	-73.6215	-800.32	-985.8449	246	71	17	33017	7	68	68
O-P	-127.1471	-77.7262			48

Interface residues

• A-B: ALA100B, ALA108B, ALA125B, ALA17B, ALA18B, ALA190A, ALA39A, ALA3B, ALA46A, ALA492A, ALA493A, ALA55B, ALA714A, ALA718A, ALA771A, ALA9B, ARG117B, ARG11B, ARG199A, ARG203A, ARG204A, ARG211A, ARG221A, ARG33A, ARG33B, ARG473A, ARG491A, ARG50A, ARG515A, ARG5B, ARG69A, ARG707A, ARG734A, ARG739A, ARG748A, ARG750A, ARG754A, ARG756A, ARG758A, ARG83B, ARG94B, ARG95B, ASN107B, ASN114B, ASN127B, ASN34B, ASN456A, ASN463A, ASN49A, ASN53A, ASN54B, ASN56B, ASN733A, ASP10B, ASP118B, ASP174A, ASP202A, ASP224A, ASP227A, ASP2B, ASP34A, ASP43A, ASP465A, ASP68A, ASP770A, ASP82B, CYS101B, CYS54A, CYS720A, CYS98B, GLN105B, GLN109B, GLN36A, GLN38B, GLN459A, GLN45A, GLN466A, GLN50B, GLN773A, GLN81B, GLN86B, GLU115B, GLU15B, GLU177A, GLU191A, GLU208A, GLU23B, GLU37B, GLU467A, GLU47A, GLU47B, GLU513A, GLU67A, GLU697A, GLU710A, GLU737A, GLU746A, GLU752A, GLU84B, GLY31A, GLY32B, GLY35A, GLY42A, GLY490A, GLY51A, GLY57A, GLY66A, GLY702A, GLY717A, GLY735A, GLY745A, GLY755A, GLY85B, GLY8B, HIS102B, HIS193A, HIS207A, HIS41A, HIS631A, HIS698A, HIS79B, ILE12A, ILE195A, ILE25B, ILE42B, ILE464A, ILE46B, ILE63A, ILE747A, LEU111B, LEU120B, LEU122B, LEU196A, LEU200A, LEU205A, LEU21B, LEU225A, LEU51B, LEU52A, LEU59B, LEU60A, LEU696A, LEU6B, LEU706A, LEU711A, LEU751A, LEU774A, LEU88B, LYS56A, LYS62A, LYS713A, LYS777A, MET119B, MET123B, MET13B, MET189A, MET29A, MET458A, MET64A, MET704A, PHE116B, PHE176A, PHE59A, PHE715A, PHE769A, PHE97B, PRO104B, PRO110B, PRO124B, PRO12B, PRO194A, PRO19B, PRO20B, PRO229A, PRO22B, PRO36B, PRO39B, PRO40B, PRO470A, PRO486A, PRO4B, PRO526A, PRO709A, PRO716A, PRO93B, SER126B, SER14B, SER198A, SER206A, SER222A, SER223A, SER226A, SER52B, SER61A, SER701A, SER703A, SER736A, SER772A, SER92B, THR106B, THR113B, THR121B, THR201A, THR228A, THR24B, THR32A, THR40A, THR44A, THR468A, THR487A, THR489A, THR705A, THR749A, THR753A, THR78B, THR7B, THR99B, TRP14A, TRP197A, TRP708A, TYR173A, TYR35B, TYR469A, TYR485A, TYR49B, TYR58A, TYR65A, TYR712A, TYR96B, VAL103B, VAL112B, VAL16B, VAL210A, VAL212A, VAL31B, VAL37A, VAL38A, VAL41B, VAL488A, VAL48A, VAL53B, VAL55A, VAL719A, VAL738A, VAL91B
• A-E: ARG50A, ARG50E, GLN45A, GLN45E, THR44A, THR44E
• A-F: ALA39A, ALA46A, ALA89F, ARG13A, ARG50A, ARG628A, ARG83F, ASN49A, ASP43A, ASP82F, ASP90F, GLN45A, GLN81F, GLN86F, GLU84F, GLY27A, GLY31A, GLY42A, GLY51A, GLY85F, HIS41A, ILE12A, ILE77F, LEU88F, LYS16A, MET29A, MET87F, PHE80F, THR44A, TRP14A, TYR58A, TYR66F, VAL28A, VAL38A
• A-G: ARG491G, ARG707G, ARG728A, ARG754A, ARG761A, ASP68G, GLU317A, GLU322A, GLU528G, GLU67G, GLU725A, GLY527G, HIS723A, LYS78G, PHE88G, PRO486G, PRO724A, PRO90G, SER729A, THR753A
• A-H: ALA3H, ALA727A, ARG5H, ARG728A, ARG734A, ARG754A, ARG758A, ASN114H, ASN733A, ASP10H, ASP2H, GLN109H, GLU725A, GLY731A, LEU111H, LEU732A, PRO110H, PRO124H, PRO4H, PRO724A, SER729A, THR113H, THR753A, THR7H, VAL112H
• A-O: ASP68A, GLU67A, GLU725O
• B-D: ARG57B, ARG57D, ARG63B, ARG63D, CYS58B, CYS61B, CYS61D, GLN65D, GLU60B, GLU60D, GLY68B, GLY68D, LEU69B, LEU69D, SER67B, SER67D, TYR49B, TYR49D, TYR66B, TYR66D, VAL70B, VAL70D
• B-E: ALA39E, ALA46E, ALA89B, ARG13E, ARG50E, ARG628E, ARG83B, ASN49E, ASP43E, ASP82B, ASP90B, GLN45E, GLN81B, GLN86B, GLU84B, GLY27E, GLY31E, GLY42E, GLY51E, GLY85B, HIS41E, ILE12E, ILE77B, LEU88B, LYS16E, MET29E, MET87B, PHE80B, THR44E, TRP14E, TYR58E, VAL28E, VAL38E
• B-F: ALA125B, ALA125F, ALA71B, ALA71F, ALA72B, ALA72F, ALA89B, ALA89F, ARG29B, ARG29F, ARG30B, ARG30F, ARG33B, ARG33F, ARG63B, ARG63F, ARG64B, ARG64F, ARG95B, ARG95F, ASN127B, ASN127F, ASN34B, ASN34F, ASP118B, ASP118F, ASP90B, ASP90F, GLN38B, GLN38F, GLN65B, GLN65F, GLN81B, GLN81F, GLN86B, GLN86F, GLU37B, GLU37F, GLY32B, GLY32F, GLY68B, GLY68F, GLY85B, GLY85F, HIS79B, HIS79F, ILE75B, ILE75F, ILE77B, ILE77F, LEU120B, LEU120F, LEU69B, LEU69F, LEU88B, LEU88F, MET119B, MET119F, MET123B, MET123F, MET87B, MET87F, PHE116F, PHE80B, PHE80F, PRO36B, PRO36F, PRO40B, PRO40F, PRO73B, PRO73F, SER126B, SER126F, SER67B, SER67F, SER76B, SER76F, THR121B, THR121F, THR78B, THR78F, TYR35B, TYR35F, TYR66B, TYR66F, VAL31B, VAL31F, VAL70B, VAL70F, VAL91B, VAL91F
• B-H: ALA125H, ALA55B, ARG117H, ARG29H, ARG33H, ARG57B, ASN127H, ASN34H, ASN54B, ASN56B, ASP118H, ASP27B, ASP28B, CYS58B, GLN50B, GLU47B, GLU60B, GLY32H, GLY48B, ILE46B, LEU120H, LEU122H, LEU51B, MET123H, PRO124H, SER126H, SER52B, THR121H, THR26B, TYR49B
• B-O: ARG5B, ARG728O, ARG754O, GLN109B
• C-D: ALA100D, ALA108D, ALA125D, ALA17D, ALA18D, ALA190C, ALA39C, ALA3D, ALA46C, ALA492C, ALA493C, ALA55D, ALA714C, ALA718C, ALA771C, ALA9D, ARG117D, ARG11D, ARG199C, ARG203C, ARG204C, ARG211C, ARG221C, ARG33C, ARG33D, ARG473C, ARG491C, ARG50C, ARG515C, ARG5D, ARG69C, ARG707C, ARG734C, ARG739C, ARG748C, ARG750C, ARG754C, ARG756C, ARG758C, ARG83D, ARG94D, ARG95D, ASN107D, ASN114D, ASN127D, ASN34D, ASN456C, ASN463C, ASN49C, ASN53C, ASN54D, ASN56D, ASN733C, ASP10D, ASP118D, ASP174C, ASP202C, ASP224C, ASP227C, ASP2D, ASP34C, ASP43C, ASP465C, ASP68C, ASP770C, ASP82D, CYS101D, CYS54C, CYS720C, CYS98D, GLN105D, GLN109D, GLN36C, GLN38D, GLN459C, GLN45C, GLN466C, GLN50D, GLN773C, GLN81D, GLN86D, GLU115D, GLU15D, GLU177C, GLU191C, GLU208C, GLU23D, GLU37D, GLU467C, GLU47C, GLU47D, GLU513C, GLU67C, GLU697C, GLU710C, GLU737C, GLU746C, GLU752C, GLU84D, GLY31C, GLY32D, GLY35C, GLY42C, GLY490C, GLY51C, GLY57C, GLY66C, GLY702C, GLY717C, GLY735C, GLY745C, GLY755C, GLY85D, GLY8D, HIS102D, HIS193C, HIS207C, HIS41C, HIS631C, HIS698C, HIS79D, ILE12C, ILE195C, ILE25D, ILE42D, ILE464C, ILE46D, ILE63C, ILE747C, LEU111D, LEU120D, LEU122D, LEU196C, LEU200C, LEU205C, LEU21D, LEU225C, LEU51D, LEU52C, LEU59D, LEU60C, LEU696C, LEU6D, LEU706C, LEU711C, LEU751C, LEU774C, LEU88D, LYS56C, LYS62C, LYS713C, LYS777C, MET119D, MET123D, MET13D, MET189C, MET29C, MET458C, MET64C, MET704C, PHE116D, PHE176C, PHE59C, PHE715C, PHE769C, PHE97D, PRO104D, PRO110D, PRO124D, PRO12D, PRO194C, PRO19D, PRO20D, PRO229C, PRO22D, PRO36D, PRO39D, PRO40D, PRO470C, PRO486C, PRO4D, PRO526C, PRO709C, PRO716C, PRO93D, SER126D, SER14D, SER198C, SER206C, SER222C, SER223C, SER226C, SER52D, SER61C, SER701C, SER703C, SER736C, SER772C, SER92D, THR106D, THR113D, THR121D, THR201C, THR228C, THR24D, THR32C, THR40C, THR44C, THR468C, THR487C, THR489C, THR705C, THR749C, THR753C, THR78D, THR7D, THR99D, TRP14C, TRP197C, TRP708C, TYR173C, TYR35D, TYR469C, TYR485C, TYR49D, TYR58C, TYR65C, TYR712C, TYR96D, VAL103D, VAL112D, VAL16D, VAL210C, VAL212C, VAL31D, VAL37C, VAL38C, VAL41D, VAL488C, VAL48C, VAL53D, VAL55C, VAL719C, VAL738C, VAL91D
• C-E: ARG491E, ARG707E, ARG728C, ARG754C, ARG761C, ASP68E, GLU67E, GLU725C, HIS723C, PHE88E, PRO486E, PRO724C, PRO90E, SER729C
• C-F: ALA3F, ALA727C, ARG5F, ARG728C, ARG734C, ARG754C, ASN114F, ASN733C, ASP2F, GLN109F, GLU725C, LEU111F, LEU732C, PRO110F, PRO724C, THR113F, THR7F, VAL112F
• C-G: ARG50C, ARG50G, GLN45C, GLN45G
• C-H: ALA39C, ALA46C, ALA89H, ARG13C, ARG50C, ARG628C, ARG83H, ASN49C, ASP43C, ASP82H, ASP90H, GLN45C, GLN81H, GLN86H, GLU84H, GLY27C, GLY31C, GLY42C, GLY51C, GLY85H, HIS41C, ILE12C, ILE77H, LEU88H, LYS16C, MET29C, MET87H, PHE80H, THR44C, TRP14C, TYR58C, TYR66H, VAL28C, VAL38C
• C-M: ARG491C, ARG707C, ARG728M, ARG754M, ARG761M, ASP68C, GLU317M, GLU322M, GLU528C, GLU67C, GLU725M, GLY527C, HIS723M, LYS78C, PHE88C, PRO486C, PRO724M, PRO90C, SER729M
• D-F: ALA125F, ALA55D, ARG117F, ARG29F, ARG57D, ASN127F, ASN34F, ASN54D, ASN56D, ASP118F, ASP27D, ASP28D, CYS58D, GLN50D, GLU47D, GLU60D, GLY48D, ILE46D, LEU120F, LEU122F, LEU51D, MET123F, PRO124F, SER126F, SER52D, THR121F, THR26D, TYR49D
• D-G: ALA39G, ALA46G, ALA89D, ARG13G, ARG50G, ARG628G, ARG83D, ASN49G, ASP43G, ASP82D, ASP90D, GLN45G, GLN81D, GLN86D, GLU84D, GLY27G, GLY31G, GLY42G, GLY51G, GLY85D, HIS41G, ILE12G, ILE77D, LEU88D, LYS16G, MET29G, MET87D, PHE80D, THR44G, TRP14G, TYR58G, TYR66D, VAL28G, VAL38G
• D-H: ALA125D, ALA125H, ALA71D, ALA71H, ALA72D, ALA72H, ALA89D, ALA89H, ARG29D, ARG29H, ARG30D, ARG30H, ARG33D, ARG33H, ARG63D, ARG63H, ARG64D, ARG64H, ARG95D, ARG95H, ASN127D, ASN127H, ASN34D, ASN34H, ASP118D, ASP118H, ASP90D, ASP90H, GLN38D, GLN38H, GLN65D, GLN65H, GLN81D, GLN81H, GLN86D, GLN86H, GLU37D, GLU37H, GLY32D, GLY32H, GLY68D, GLY68H, GLY85D, GLY85H, HIS79D, HIS79H, ILE75D, ILE75H, ILE77D, ILE77H, LEU120D, LEU120H, LEU69D, LEU69H, LEU88D, LEU88H, MET119D, MET119H, MET123D, MET123H, MET87D, MET87H, PHE116H, PHE80D, PHE80H, PRO36D, PRO36H, PRO40D, PRO40H, PRO73D, PRO73H, SER126D, SER126H, SER67D, SER67H, SER76D, SER76H, THR121D, THR121H, THR78D, THR78H, TYR35D, TYR35H, TYR66D, TYR66H, VAL31D, VAL31H, VAL70D, VAL70H, VAL91D, VAL91H
• D-M: ALA3D, ALA727M, ARG5D, ARG728M, ARG734M, ARG754M, ASN114D, ASN733M, ASP10D, ASP2D, GLN109D, GLU725M, LEU111D, LEU732M, PRO110D, PRO4D, PRO724M, SER729M, THR113D, THR7D, VAL112D
• D-N: ALA125D, ALA55N, ARG117D, ARG29D, ARG57N, ASN127D, ASN34D, ASN54N, ASN56N, ASP118D, ASP27N, ASP28N, CYS58N, GLN50N, GLU47N, GLU60N, GLY32D, GLY48N, ILE46N, LEU120D, LEU122D, LEU51N, MET123D, PRO124D, SER126D, SER45N, SER52N, THR121D, THR26N, TYR49N
• E-F: ALA100F, ALA108F, ALA125F, ALA17F, ALA18F, ALA190E, ALA39E, ALA3F, ALA46E, ALA492E, ALA493E, ALA55F, ALA714E, ALA718E, ALA771E, ALA9F, ARG117F, ARG11F, ARG199E, ARG203E, ARG204E, ARG211E, ARG221E, ARG33E, ARG33F, ARG473E, ARG491E, ARG50E, ARG515E, ARG5F, ARG69E, ARG707E, ARG734E, ARG739E, ARG748E, ARG750E, ARG754E, ARG756E, ARG758E, ARG83F, ARG94F, ARG95F, ASN107F, ASN114F, ASN127F, ASN34F, ASN456E, ASN463E, ASN49E, ASN53E, ASN54F, ASN56F, ASN733E, ASP10F, ASP118F, ASP174E, ASP202E, ASP224E, ASP227E, ASP2F, ASP34E, ASP43E, ASP465E, ASP68E, ASP770E, ASP82F, CYS101F, CYS54E, CYS720E, CYS98F, GLN105F, GLN109F, GLN36E, GLN38F, GLN459E, GLN45E, GLN466E, GLN50F, GLN773E, GLN81F, GLN86F, GLU115F, GLU15F, GLU177E, GLU191E, GLU208E, GLU23F, GLU37F, GLU467E, GLU47E, GLU47F, GLU513E, GLU67E, GLU697E, GLU710E, GLU737E, GLU746E, GLU752E, GLU84F, GLY31E, GLY32F, GLY35E, GLY42E, GLY490E, GLY51E, GLY57E, GLY66E, GLY702E, GLY717E, GLY735E, GLY745E, GLY755E, GLY85F, GLY8F, HIS102F, HIS193E, HIS207E, HIS41E, HIS631E, HIS698E, HIS79F, ILE12E, ILE195E, ILE25F, ILE42F, ILE464E, ILE46F, ILE63E, ILE747E, LEU111F, LEU120F, LEU122F, LEU196E, LEU200E, LEU205E, LEU21F, LEU225E, LEU51F, LEU52E, LEU59F, LEU60E, LEU696E, LEU6F, LEU706E, LEU711E, LEU751E, LEU774E, LEU88F, LYS56E, LYS62E, LYS713E, LYS777E, MET119F, MET123F, MET13F, MET189E, MET29E, MET458E, MET64E, MET704E, PHE116F, PHE176E, PHE59E, PHE715E, PHE769E, PHE97F, PRO104F, PRO110F, PRO124F, PRO12F, PRO194E, PRO19F, PRO20F, PRO229E, PRO22F, PRO36F, PRO39F, PRO40F, PRO470E, PRO486E, PRO4F, PRO526E, PRO709E, PRO716E, PRO93F, SER126F, SER14F, SER198E, SER206E, SER222E, SER223E, SER226E, SER52F, SER61E, SER701E, SER703E, SER736E, SER772E, SER92F, THR106F, THR113F, THR121F, THR201E, THR228E, THR24F, THR32E, THR40E, THR44E, THR468E, THR487E, THR489E, THR705E, THR749E, THR753E, THR78F, THR7F, THR99F, TRP14E, TRP197E, TRP708E, TYR173E, TYR35F, TYR469E, TYR485E, TYR49F, TYR58E, TYR65E, TYR712E, TYR96F, VAL103F, VAL112F, VAL16F, VAL210E, VAL212E, VAL31F, VAL37E, VAL38E, VAL41F, VAL488E, VAL48E, VAL53F, VAL55E, VAL719E, VAL738E, VAL91F
• E-I: ARG491I, ARG707I, ARG728E, ARG754E, ARG761E, ASP68I, GLU322E, GLU528I, GLU67I, GLU725E, HIS723E, PHE88I, PRO486I, PRO724E, PRO90I, SER729E
• E-J: ALA3J, ALA727E, ARG5J, ARG728E, ARG734E, ARG754E, ASN114J, ASN733E, ASP2J, GLN109J, GLU725E, LEU111J, LEU732E, PRO110J, PRO4J, PRO724E, SER729E, THR113J, THR7J, VAL112J
• F-J: ALA125J, ALA55F, ARG117J, ARG29J, ARG57F, ASN127J, ASN34J, ASN54F, ASN56F, ASP118J, ASP27F, ASP28F, CYS58F, GLN50F, GLU47F, GLU60F, GLY32J, GLY48F, ILE46F, LEU120J, LEU122J, LEU51F, MET123J, PRO124J, SER126J, SER52F, THR121J, THR26F, TYR49F
• F-P: ARG57F, SER67P
• G-H: ALA100H, ALA108H, ALA125H, ALA17H, ALA18H, ALA190G, ALA39G, ALA3H, ALA46G, ALA492G, ALA493G, ALA55H, ALA714G, ALA718G, ALA771G, ALA9H, ARG117H, ARG11H, ARG199G, ARG203G, ARG204G, ARG211G, ARG221G, ARG33G, ARG33H, ARG473G, ARG491G, ARG50G, ARG515G, ARG5H, ARG69G, ARG707G, ARG734G, ARG739G, ARG748G, ARG750G, ARG754G, ARG756G, ARG758G, ARG83H, ARG94H, ARG95H, ASN107H, ASN114H, ASN127H, ASN34H, ASN456G, ASN463G, ASN49G, ASN53G, ASN54H, ASN56H, ASN733G, ASP10H, ASP118H, ASP174G, ASP202G, ASP224G, ASP227G, ASP2H, ASP34G, ASP43G, ASP465G, ASP68G, ASP770G, ASP82H, CYS101H, CYS54G, CYS720G, CYS98H, GLN105H, GLN109H, GLN36G, GLN38H, GLN459G, GLN45G, GLN466G, GLN50H, GLN773G, GLN81H, GLN86H, GLU115H, GLU15H, GLU177G, GLU191G, GLU208G, GLU23H, GLU37H, GLU467G, GLU47G, GLU47H, GLU513G, GLU67G, GLU697G, GLU710G, GLU737G, GLU746G, GLU752G, GLU84H, GLY31G, GLY32H, GLY35G, GLY42G, GLY490G, GLY51G, GLY57G, GLY66G, GLY702G, GLY717G, GLY735G, GLY745G, GLY755G, GLY85H, GLY8H, HIS102H, HIS193G, HIS207G, HIS41G, HIS631G, HIS698G, HIS79H, ILE12G, ILE195G, ILE25H, ILE42H, ILE464G, ILE46H, ILE63G, ILE747G, LEU111H, LEU120H, LEU122H, LEU196G, LEU200G, LEU205G, LEU21H, LEU225G, LEU51H, LEU52G, LEU59H, LEU60G, LEU696G, LEU6H, LEU706G, LEU711G, LEU751G, LEU774G, LEU88H, LYS56G, LYS62G, LYS713G, LYS777G, MET119H, MET123H, MET13H, MET189G, MET29G, MET458G, MET64G, MET704G, PHE116H, PHE176G, PHE59G, PHE715G, PHE769G, PHE97H, PRO104H, PRO110H, PRO124H, PRO12H, PRO194G, PRO19H, PRO20H, PRO229G, PRO22H, PRO36H, PRO39H, PRO40H, PRO470G, PRO486G, PRO4H, PRO526G, PRO709G, PRO716G, PRO93H, SER126H, SER14H, SER198G, SER206G, SER222G, SER223G, SER226G, SER52H, SER61G, SER701G, SER703G, SER736G, SER772G, SER92H, THR106H, THR113H, THR121H, THR201G, THR228G, THR24H, THR32G, THR40G, THR44G, THR468G, THR487G, THR489G, THR705G, THR749G, THR753G, THR78H, THR7H, THR99H, TRP14G, TRP197G, TRP708G, TYR173G, TYR35H, TYR469G, TYR485G, TYR49H, TYR58G, TYR65G, TYR712G, TYR96H, VAL103H, VAL112H, VAL16H, VAL210G, VAL212G, VAL31H, VAL37G, VAL38G, VAL41H, VAL488G, VAL48G, VAL53H, VAL55G, VAL695G, VAL719G, VAL738G, VAL91H
• G-K: ARG491K, ARG707K, ARG728G, ARG754G, ARG761G, ASP68K, GLU317G, GLU322G, GLU528K, GLU67K, GLU725G, GLY527K, HIS723G, LYS78K, PHE88K, PRO486K, PRO724G, PRO90K, SER729G
• G-L: ALA3L, ALA727G, ARG5L, ARG728G, ARG734G, ARG754G, ASN114L, ASN733G, ASP10L, ASP2L, GLN109L, GLU725G, GLY731G, LEU111L, LEU732G, PRO110L, PRO4L, PRO724G, SER729G, THR113L, THR753G, THR7L, VAL112L
• H-L: ALA125L, ALA55H, ARG117L, ARG29L, ARG57H, ASN127L, ASN34L, ASN54H, ASN56H, ASP118L, ASP27H, ASP28H, CYS58H, GLN50H, GLU47H, GLU60H, GLY32L, GLY48H, ILE46H, LEU120L, LEU122L, LEU51H, MET123L, PRO124L, SER126L, SER52H, THR121L, THR26H, TYR49H
• H-N: ARG57H, ARG57N, ARG63H, ARG63N, CYS58N, CYS61H, CYS61N, GLU60H, GLU60N, GLY68H, GLY68N, LEU59N, LEU69H, LEU69N, SER67H, SER67N, TYR49H, TYR49N, TYR66H, TYR66N, VAL70H, VAL70N
• I-J: ALA100J, ALA108J, ALA125J, ALA17J, ALA18J, ALA190I, ALA39I, ALA3J, ALA46I, ALA492I, ALA493I, ALA55J, ALA714I, ALA718I, ALA771I, ALA9J, ARG117J, ARG11J, ARG199I, ARG203I, ARG204I, ARG211I, ARG221I, ARG33I, ARG33J, ARG473I, ARG491I, ARG50I, ARG515I, ARG5J, ARG69I, ARG707I, ARG734I, ARG739I, ARG748I, ARG750I, ARG754I, ARG756I, ARG758I, ARG83J, ARG94J, ARG95J, ASN107J, ASN114J, ASN127J, ASN34J, ASN456I, ASN463I, ASN49I, ASN53I, ASN54J, ASN56J, ASN733I, ASP10J, ASP118J, ASP174I, ASP202I, ASP224I, ASP227I, ASP2J, ASP34I, ASP43I, ASP465I, ASP68I, ASP770I, ASP82J, CYS101J, CYS54I, CYS720I, CYS98J, GLN105J, GLN109J, GLN36I, GLN38J, GLN459I, GLN45I, GLN466I, GLN50J, GLN773I, GLN81J, GLN86J, GLU115J, GLU15J, GLU177I, GLU191I, GLU208I, GLU23J, GLU37J, GLU467I, GLU47I, GLU47J, GLU513I, GLU67I, GLU697I, GLU710I, GLU737I, GLU746I, GLU752I, GLU84J, GLY31I, GLY32J, GLY35I, GLY42I, GLY490I, GLY51I, GLY57I, GLY66I, GLY702I, GLY717I, GLY735I, GLY745I, GLY755I, GLY85J, GLY8J, HIS102J, HIS193I, HIS207I, HIS41I, HIS631I, HIS698I, HIS79J, ILE12I, ILE195I, ILE25J, ILE42J, ILE464I, ILE46J, ILE63I, ILE747I, LEU111J, LEU120J, LEU122J, LEU196I, LEU200I, LEU205I, LEU21J, LEU225I, LEU51J, LEU52I, LEU59J, LEU60I, LEU696I, LEU6J, LEU706I, LEU711I, LEU751I, LEU774I, LEU88J, LYS56I, LYS62I, LYS713I, LYS777I, MET119J, MET123J, MET13J, MET189I, MET29I, MET458I, MET64I, MET704I, PHE116J, PHE176I, PHE59I, PHE715I, PHE769I, PHE97J, PRO104J, PRO110J, PRO124J, PRO12J, PRO194I, PRO19J, PRO20J, PRO229I, PRO22J, PRO36J, PRO39J, PRO40J, PRO470I, PRO486I, PRO4J, PRO526I, PRO709I, PRO716I, PRO93J, SER126J, SER14J, SER198I, SER206I, SER222I, SER223I, SER226I, SER52J, SER61I, SER701I, SER703I, SER736I, SER772I, SER92J, THR106J, THR113J, THR121J, THR201I, THR228I, THR24J, THR32I, THR40I, THR44I, THR468I, THR487I, THR489I, THR705I, THR749I, THR753I, THR78J, THR7J, THR99J, TRP14I, TRP197I, TRP708I, TYR173I, TYR35J, TYR469I, TYR485I, TYR49J, TYR58I, TYR65I, TYR712I, TYR96J, VAL103J, VAL112J, VAL16J, VAL210I, VAL212I, VAL28I, VAL31J, VAL37I, VAL38I, VAL41J, VAL488I, VAL48I, VAL53J, VAL55I, VAL695I, VAL719I, VAL738I, VAL91J
• I-M: ARG491M, ARG707M, ARG728I, ARG754I, ARG761I, ASP68M, GLU322I, GLU528M, GLU67M, GLU725I, GLY527M, HIS723I, PHE88M, PRO486M, PRO724I, PRO90M, SER729I
• I-N: ALA3N, ALA727I, ARG5N, ARG728I, ARG734I, ARG754I, ASN114N, ASN733I, ASP2N, GLN109N, GLU725I, LEU111N, LEU732I, PRO110N, PRO4N, PRO724I, SER729I, THR113N, THR7N, VAL112N
• I-O: ARG50I, ARG50O, GLN45I, GLN45O, THR44O
• I-P: ASP43I, GLU84P
• J-L: ARG57J, ARG57L, ARG63J, ARG63L, CYS58J, CYS58L, CYS61J, CYS61L, GLU60J, GLU60L, GLY68J, GLY68L, LEU59L, LEU69J, LEU69L, SER67J, SER67L, TYR49J, TYR49L, TYR66J, TYR66L, VAL70J, VAL70L
• J-N: ALA125N, ALA55J, ARG117N, ARG29N, ARG57J, ASN127N, ASN34N, ASN54J, ASN56J, ASP118N, ASP27J, ASP28J, CYS58J, GLN50J, GLU47J, GLU60J, GLY32N, GLY48J, ILE46J, LEU120N, LEU122N, LEU51J, MET123N, PRO124N, SER126N, SER52J, THR121N, THR26J, TYR49J
• J-O: ALA39O, ALA46O, ALA89J, ARG13O, ARG50O, ARG83J, ASN49O, ASP43O, ASP82J, ASP90J, GLN45O, GLN81J, GLN86J, GLU84J, GLY31O, GLY42O, GLY51O, GLY85J, HIS41O, ILE12O, ILE77J, LEU88J, LYS16O, MET29O, MET87J, PHE80J, THR44O, TRP14O, VAL28O, VAL38O
• J-P: ARG33J, ARG33P, ARG64J, ARG64P, GLY68J, GLY68P
• K-L: ALA100L, ALA108L, ALA125L, ALA17L, ALA18L, ALA190K, ALA39K, ALA3L, ALA46K, ALA492K, ALA493K, ALA55L, ALA714K, ALA718K, ALA771K, ALA9L, ARG117L, ARG11L, ARG199K, ARG203K, ARG204K, ARG211K, ARG221K, ARG33K, ARG33L, ARG473K, ARG491K, ARG50K, ARG515K, ARG5L, ARG69K, ARG707K, ARG734K, ARG739K, ARG748K, ARG750K, ARG754K, ARG756K, ARG758K, ARG83L, ARG94L, ARG95L, ASN107L, ASN114L, ASN127L, ASN34L, ASN456K, ASN463K, ASN49K, ASN53K, ASN54L, ASN56L, ASN733K, ASP10L, ASP118L, ASP174K, ASP202K, ASP224K, ASP227K, ASP2L, ASP34K, ASP43K, ASP465K, ASP68K, ASP770K, ASP82L, CYS101L, CYS26K, CYS54K, CYS720K, CYS98L, GLN105L, GLN109L, GLN36K, GLN38L, GLN459K, GLN45K, GLN466K, GLN50L, GLN773K, GLN81L, GLN86L, GLU115L, GLU15L, GLU177K, GLU191K, GLU208K, GLU23L, GLU37L, GLU467K, GLU47K, GLU47L, GLU513K, GLU67K, GLU697K, GLU710K, GLU737K, GLU746K, GLU752K, GLU84L, GLY31K, GLY32L, GLY35K, GLY42K, GLY490K, GLY51K, GLY57K, GLY66K, GLY702K, GLY717K, GLY735K, GLY745K, GLY755K, GLY85L, GLY8L, HIS102L, HIS193K, HIS207K, HIS41K, HIS631K, HIS698K, HIS79L, ILE12K, ILE195K, ILE25L, ILE42L, ILE464K, ILE46L, ILE63K, ILE747K, LEU111L, LEU120L, LEU122L, LEU196K, LEU200K, LEU205K, LEU21L, LEU225K, LEU51L, LEU52K, LEU59L, LEU60K, LEU696K, LEU6L, LEU706K, LEU711K, LEU751K, LEU774K, LEU88L, LYS56K, LYS62K, LYS713K, LYS777K, MET119L, MET123L, MET13L, MET189K, MET29K, MET458K, MET64K, MET704K, PHE116L, PHE176K, PHE59K, PHE715K, PHE769K, PHE97L, PRO104L, PRO110L, PRO124L, PRO12L, PRO194K, PRO19L, PRO20L, PRO229K, PRO22L, PRO36L, PRO39L, PRO40L, PRO470K, PRO486K, PRO4L, PRO526K, PRO709K, PRO716K, PRO93L, SER126L, SER14L, SER198K, SER206K, SER222K, SER223K, SER226K, SER52L, SER61K, SER701K, SER703K, SER736K, SER772K, SER92L, THR106L, THR113L, THR121L, THR201K, THR228K, THR24L, THR32K, THR40K, THR44K, THR468K, THR487K, THR489K, THR705K, THR749K, THR753K, THR78L, THR7L, THR99L, TRP14K, TRP197K, TRP708K, TYR173K, TYR35L, TYR469K, TYR485K, TYR49L, TYR58K, TYR65K, TYR712K, TYR96L, VAL103L, VAL112L, VAL16L, VAL210K, VAL212K, VAL31L, VAL37K, VAL38K, VAL41L, VAL488K, VAL48K, VAL53L, VAL55K, VAL695K, VAL719K, VAL738K, VAL91L
• K-M: ARG50K, ARG50M, GLN45K, GLN45M, THR44K, THR44M
• K-N: ALA39K, ALA46K, ALA89N, ARG13K, ARG50K, ARG628K, ARG83N, ASN49K, ASP43K, ASP82N, ASP90N, GLN45K, GLN81N, GLN86N, GLU84N, GLY27K, GLY31K, GLY42K, GLY51K, GLY68N, GLY85N, HIS41K, ILE12K, ILE77N, LEU88N, LYS16K, LYS62K, MET29K, MET87N, PHE80N, THR44K, TRP14K, TYR58K, TYR66N, VAL28K, VAL30K, VAL38K
• K-O: ARG728K, ARG754K, ASP68O, GLU67O, GLU725K, HIS723K, PRO724K
• K-P: ARG5P, ARG728K, ARG754K, GLN109P, GLU725K
• L-M: ALA39M, ALA46M, ALA89L, ARG13M, ARG50M, ARG628M, ARG83L, ASN49M, ASP43M, ASP82L, ASP90L, GLN45M, GLN81L, GLN86L, GLU84L, GLY31M, GLY42M, GLY51M, GLY85L, HIS41M, ILE12M, ILE77L, LEU88L, LYS16M, MET29M, MET87L, PHE80L, THR44M, TRP14M, TYR58M, TYR66L, VAL28M, VAL38M
• L-N: ALA125L, ALA125N, ALA71L, ALA71N, ALA72L, ALA72N, ALA89L, ALA89N, ARG29L, ARG29N, ARG30L, ARG30N, ARG33L, ARG33N, ARG63L, ARG63N, ARG64L, ARG64N, ARG95L, ARG95N, ASN127L, ASN127N, ASN34L, ASN34N, ASP118L, ASP118N, ASP90L, ASP90N, GLN38L, GLN38N, GLN65L, GLN65N, GLN81L, GLN81N, GLN86L, GLN86N, GLU37L, GLU37N, GLY32L, GLY32N, GLY68L, GLY68N, GLY85L, GLY85N, HIS79L, HIS79N, ILE75L, ILE75N, ILE77L, ILE77N, LEU120L, LEU120N, LEU69L, LEU69N, LEU88L, LEU88N, MET119L, MET119N, MET123L, MET123N, MET87L, MET87N, PHE116L, PHE116N, PHE80L, PHE80N, PRO36L, PRO36N, PRO40L, PRO40N, PRO73L, PRO73N, SER126L, SER126N, SER67L, SER67N, SER76L, SER76N, THR121L, THR121N, THR78L, THR78N, TYR35L, TYR35N, TYR66L, TYR66N, VAL31L, VAL31N, VAL70L, VAL70N, VAL91L, VAL91N
• L-P: ARG57L, SER126P
• M-N: ALA100N, ALA108N, ALA125N, ALA17N, ALA18N, ALA190M, ALA39M, ALA3N, ALA46M, ALA492M, ALA493M, ALA55N, ALA714M, ALA718M, ALA771M, ALA9N, ARG117N, ARG11N, ARG199M, ARG203M, ARG204M, ARG211M, ARG221M, ARG33M, ARG33N, ARG473M, ARG491M, ARG50M, ARG515M, ARG5N, ARG69M, ARG707M, ARG734M, ARG739M, ARG748M, ARG750M, ARG754M, ARG756M, ARG758M, ARG83N, ARG94N, ARG95N, ASN107N, ASN114N, ASN127N, ASN34N, ASN456M, ASN463M, ASN49M, ASN53M, ASN54N, ASN56N, ASN733M, ASP10N, ASP118N, ASP174M, ASP202M, ASP224M, ASP227M, ASP2N, ASP34M, ASP43M, ASP465M, ASP68M, ASP770M, ASP82N, CYS101N, CYS54M, CYS720M, CYS98N, GLN105N, GLN109N, GLN36M, GLN38N, GLN459M, GLN45M, GLN466M, GLN50N, GLN773M, GLN81N, GLN86N, GLU115N, GLU15N, GLU177M, GLU191M, GLU208M, GLU23N, GLU37N, GLU467M, GLU47M, GLU47N, GLU513M, GLU67M, GLU697M, GLU710M, GLU737M, GLU746M, GLU752M, GLU84N, GLY31M, GLY32N, GLY35M, GLY42M, GLY490M, GLY51M, GLY57M, GLY66M, GLY702M, GLY717M, GLY735M, GLY745M, GLY755M, GLY85N, GLY8N, HIS102N, HIS193M, HIS207M, HIS41M, HIS631M, HIS698M, HIS79N, ILE12M, ILE195M, ILE25N, ILE42N, ILE464M, ILE46N, ILE63M, ILE747M, LEU111N, LEU120N, LEU122N, LEU196M, LEU200M, LEU205M, LEU21N, LEU225M, LEU51N, LEU52M, LEU59N, LEU60M, LEU696M, LEU6N, LEU706M, LEU711M, LEU751M, LEU774M, LEU88N, LYS56M, LYS62M, LYS713M, LYS777M, MET119N, MET123N, MET13N, MET189M, MET29M, MET458M, MET64M, MET704M, PHE116N, PHE176M, PHE59M, PHE715M, PHE769M, PHE97N, PRO104N, PRO110N, PRO124N, PRO12N, PRO194M, PRO19N, PRO20N, PRO229M, PRO22N, PRO36N, PRO39N, PRO40N, PRO470M, PRO486M, PRO4N, PRO526M, PRO709M, PRO716M, PRO93N, SER126N, SER14N, SER198M, SER206M, SER222M, SER223M, SER226M, SER52N, SER61M, SER701M, SER703M, SER736M, SER772M, SER92N, THR106N, THR113N, THR121N, THR201M, THR228M, THR24N, THR32M, THR40M, THR44M, THR468M, THR487M, THR489M, THR705M, THR749M, THR753M, THR78N, THR7N, THR99N, TRP14M, TRP197M, TRP708M, TYR173M, TYR35N, TYR469M, TYR485M, TYR49N, TYR58M, TYR65M, TYR712M, TYR96N, VAL103N, VAL112N, VAL16N, VAL210M, VAL212M, VAL31N, VAL37M, VAL38M, VAL41N, VAL488M, VAL48M, VAL53N, VAL55M, VAL695M, VAL719M, VAL738M, VAL91N
• O-P: ALA100P, ALA18P, ALA771O, ARG117P, ARG199O, ARG33O, ARG491O, ARG50O, ARG5P, ARG69O, ARG748O, ARG750O, ARG754O, ARG83P, ARG94P, ASN114P, ASP10P, ASP118P, ASP202O, ASP224O, ASP34O, ASP68O, ASP82P, GLU115P, GLU15P, GLU177O, GLU37P, GLU47O, GLU47P, GLU67O, GLU746O, GLU84P, GLY42O, HIS41O, LEU6P, LYS62O, LYS713O, LYS777O, MET119P, MET13P, PRO36P, THR106P, THR113P, TYR35P, TYR58O, TYR65O, VAL53P, VAL55O