1NY6

crystal structure of sigm54 activator (aaa+ atpase) in the active state

• Total interactions analyzed: 91
• Total true interactions: 33
• Strongest Interaction:
  • Chains: L-M
  • Int. Res.: 147
  • Norm. En. per Res.: -2.9949
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-41.6455	-108.5303	-238.864	-389.0398	142	13	4	12472	9	70	59
A-C	0.0	0.0	-0.0167	-0.0167	2	0	0	4	0	0	0
A-G	-19.6567	2.9087	-186.63	-203.378	121	12	4	9134	1	56	44
A-K	0.0	-11.4539	-6.3541	-17.808	17	0	0	453	2	17	17
A-L	-11.1026	-40.4478	-35.1508	-86.7012	46	7	0	2150	2	19	23
B-C	-39.4824	-71.8404	-243.958	-355.2808	140	25	4	12981	6	71	63
B-K	0.0	14.5495	-33.2893	-18.7398	28	1	0	1649	1	16	16
B-L	0.0	0.0	-5.8585	-5.8585	13	0	0	370	0	8	5
C-D	-21.1277	32.0313	-226.329	-215.4254	126	27	5	11588	4	70	50
D-E	-40.3885	-84.5301	-207.936	-332.8546	132	25	4	11641	5	68	60
D-J	0.0	0.0	-1.0051	-1.0051	9	0	0	148	0	7	6
E-F	-30.1572	-28.5948	-224.642	-283.394	130	22	4	10947	8	64	56
E-G	0.0	0.0	-0.0037	-0.0037	2	0	0	4	0	0	0
E-I	0.0	-1.8537	-0.0308	-1.8845	5	0	0	18	0	7	7
E-J	0.0	0.0	-0.0399	-0.0399	2	0	0	10	0	0	1
F-G	-40.3708	-99.0956	-255.417	-394.8833	142	19	5	13273	8	69	58
F-H	0.0	-12.7616	-8.6406	-21.4022	16	0	0	641	1	13	14
F-I	-11.5484	2.013	-30.1218	-39.6573	33	3	0	1588	0	7	8
G-K	0.0	-4.5012	-0.494	-4.9952	3	0	0	73	0	4	5
G-M	0.0	0.0	-0.0008	-0.0008	2	0	0	2	0	2	3
G-N	0.0	-13.1706	-16.7322	-29.9028	17	1	0	816	2	12	13
H-I	-35.1932	-58.6779	-222.853	-316.7241	136	30	4	12277	10	66	59
H-M	0.0	0.0	-0.0013	-0.0013	2	0	0	3	0	0	0
H-N	-30.1678	-85.7423	-243.603	-359.5131	131	25	4	12670	6	61	56
I-J	-50.102	-21.5837	-140.396	-212.0817	109	34	5	8678	1	55	47
I-M	0.0	0.0	-0.0226	-0.0226	3	0	0	12	0	0	0
I-N	0.0	0.0	-0.0373	-0.0373	4	0	0	20	0	0	0
J-K	-21.2308	-90.3397	-179.278	-290.8486	131	10	3	10621	4	62	52
J-L	0.0	0.0	-0.0247	-0.0247	2	0	0	17	0	0	0
K-L	-30.9067	-126.3365	-198.91	-356.1532	133	21	4	11698	4	64	55
K-M	0.0	0.0	-0.0144	-0.0144	3	0	0	11	0	0	0
L-M	-36.7648	-116.9777	-286.513	-440.2555	147	32	5	13657	6	70	58
M-N	-26.4186	15.4724	-164.109	-175.0553	114	20	4	9511	0	57	47

Interface residues

• A-B: ALA159A, ALA193B, ALA197B, ALA206B, ALA215A, ALA219A, ALA219B, ALA230B, ALA247A, ALA249A, ALA333B, ALA366B, ARG178B, ARG186A, ARG201A, ARG201B, ARG253A, ARG262A, ARG262B, ARG266A, ARG274A, ARG281B, ARG293A, ARG299A, ARG357B, ARG365B, ASN195B, ASN280B, ASN355B, ASN361B, ASP185A, ASP238B, ASP295A, CYS158A, CYS161A, GLN248A, GLU151A, GLU160A, GLU174B, GLU205A, GLU207B, GLU212A, GLU224B, GLU228B, GLU239B, GLU242B, GLU246A, GLU256A, GLU268A, GLU294A, GLU304A, GLU306A, GLU358B, GLU364B, GLU371B, GLY170B, GLY210B, GLY214A, GLY218A, GLY218B, GLY225B, GLY264A, GLY265A, GLY301A, GLY354B, ILE153A, ILE156A, ILE199B, ILE203B, ILE255A, ILE303A, ILE305A, ILE363B, LEU194B, LEU208B, LEU229B, LEU235B, LEU245A, LEU251A, LEU252A, LEU263A, LEU296A, LEU300A, LEU359B, LEU368B, LEU383B, LYS152A, LYS154A, LYS155A, LYS173B, LYS213A, LYS223B, LYS250A, LYS259A, LYS267A, LYS284A, LYS331B, LYS334B, LYS360B, PHE191B, PHE204B, PHE209A, PHE209B, PHE216A, PHE216B, PHE226B, PHE227B, PHE236B, PHE260A, PHE328B, PHE369B, PRO162A, PRO190B, PRO200B, SER157A, SER169B, SER198B, SER221B, SER222B, SER244A, SER257A, SER370B, THR217A, THR217B, TRP352B, TYR211A, TYR211B, TYR261A, TYR297A, TYR298A, TYR332B, TYR350B, TYR353B, VAL163A, VAL192B, VAL196B, VAL220A, VAL220B, VAL254A, VAL302A, VAL362B, VAL384B
• A-C: GLY218C, THR217A
• A-G: ALA159G, ALA193A, ALA197A, ALA206A, ALA215G, ALA219A, ALA249G, ALA333A, ALA366A, ARG201A, ARG253G, ARG266G, ARG274G, ARG281A, ARG293G, ARG299G, ARG357A, ARG365A, ASN195A, ASN280A, ASN355A, ASN361A, ASP185G, ASP202A, ASP295G, CYS158G, CYS161G, CYS382A, GLN248G, GLU148G, GLU151G, GLU160G, GLU168A, GLU174A, GLU205G, GLU207A, GLU212G, GLU224A, GLU239A, GLU242A, GLU246G, GLU256G, GLU268G, GLU294G, GLU304G, GLU306G, GLU358A, GLU364A, GLU371A, GLU379A, GLY170A, GLY210A, GLY214G, GLY218A, GLY225A, GLY264G, GLY265G, GLY301G, GLY354A, GLY372A, ILE149G, ILE153G, ILE156G, ILE199A, ILE203A, ILE255G, ILE303G, ILE305G, ILE363A, LEU150G, LEU164G, LEU194A, LEU208A, LEU229A, LEU245G, LEU251G, LEU252G, LEU263G, LEU300G, LEU359A, LEU368A, LEU383A, LYS152G, LYS154G, LYS155G, LYS213G, LYS223A, LYS250G, LYS267G, LYS284G, LYS331A, LYS334A, LYS360A, PHE216A, PHE226A, PHE227A, PHE328A, PHE369A, PRO162G, PRO200A, SER157G, SER169A, SER198A, SER257G, SER370A, THR217A, TRP352A, TYR211A, TYR261G, TYR297G, TYR298G, TYR332A, TYR350A, TYR353A, VAL163G, VAL192A, VAL196A, VAL254G, VAL302G, VAL362A, VAL367A
• A-K: ARG311A, ARG311K, ASN282A, ASN282K, GLU168A, GLU285A, GLU306K, GLU312A, GLU312K, LYS145K, LYS288A, LYS288K, PRO308K, PRO309A, PRO309K, TYR298A, TYR353A
• A-L: ARG281L, ARG311A, ARG311L, ARG313A, ARG377A, ARG377L, ASN282L, ASP316A, GLU148A, GLU168L, GLU285L, GLU289L, GLU312A, GLU315A, GLU345A, GLY378A, ILE283L, ILE317A, ILE318A, LEU286L, LEU310A, LEU346A, LEU346L, LEU348A, LYS145A, LYS152A, LYS284L, LYS288L, LYS314A, LYS314L, PRO144A, PRO308A, PRO309A, PRO309L, PRO351A, PRO351L, SER143A, SER342A, SER349A, SER349L, SER381A, TRP352L, TYR350A, TYR350L, TYR353L, VAL384A
• B-C: ALA159B, ALA193C, ALA197C, ALA206B, ALA206C, ALA215B, ALA215C, ALA219B, ALA219C, ALA230C, ALA247B, ALA249B, ALA366C, ARG178C, ARG201B, ARG201C, ARG253B, ARG262B, ARG266B, ARG274B, ARG281C, ARG293B, ARG299B, ARG311C, ARG357C, ARG365C, ASN195C, ASN272B, ASN280C, ASN355C, ASN361C, ASP202B, ASP202C, ASP238C, ASP295B, CYS158B, CYS161B, GLN248B, GLU151B, GLU160B, GLU168C, GLU174C, GLU205B, GLU207C, GLU212B, GLU224C, GLU228C, GLU239C, GLU242C, GLU246B, GLU256B, GLU268B, GLU294B, GLU304B, GLU358C, GLU364C, GLU371C, GLY170C, GLY210C, GLY214B, GLY218B, GLY218C, GLY225C, GLY264B, GLY265B, GLY301B, GLY354C, ILE153B, ILE156B, ILE199C, ILE203C, ILE255B, ILE303B, ILE305B, ILE363C, LEU194C, LEU208C, LEU229C, LEU245B, LEU251B, LEU252B, LEU263B, LEU296B, LEU300B, LEU359C, LEU368C, LEU383C, LYS152B, LYS155B, LYS173C, LYS213B, LYS223C, LYS250B, LYS259B, LYS267B, LYS327C, LYS331C, LYS334C, LYS360C, PHE191C, PHE204B, PHE204C, PHE209B, PHE209C, PHE216B, PHE216C, PHE226C, PHE227C, PHE260B, PHE328C, PHE369C, PRO162B, PRO190C, PRO200C, PRO351C, SER157B, SER169C, SER198C, SER221C, SER244B, SER257B, SER370C, THR217B, THR217C, TRP352C, TYR211B, TYR211C, TYR261B, TYR297B, TYR298B, TYR332C, TYR350C, TYR353C, VAL163B, VAL192C, VAL196C, VAL220B, VAL220C, VAL302B, VAL362C
• B-K: ARG311B, ARG377K, ASN282B, GLN344K, GLU148K, GLU285B, GLU289B, GLU315K, GLU345K, GLY290B, LEU286B, LEU346K, LEU347K, LEU348K, LYS145K, LYS284B, LYS288B, LYS291B, LYS314K, LYS341K, PRO144K, PRO351B, PRO351K, SER342K, SER349K, TYR350K, TYR353B, VAL287B
• B-L: ARG377B, ARG377L, ASP376L, CYS382B, GLU379L, GLY378B, GLY378L, LEU346L, LEU380L, LEU383B, SER342L, SER381B, SER381L
• C-D: ALA159C, ALA193D, ALA197D, ALA206D, ALA215D, ALA219D, ALA247C, ALA249C, ALA333D, ALA366D, ARG201D, ARG253C, ARG262C, ARG266C, ARG274C, ARG281D, ARG293C, ARG299C, ARG311D, ARG357D, ARG365D, ASN195D, ASN280D, ASN355D, ASN361D, ASP202D, ASP238D, ASP295C, CYS158C, CYS161C, CYS382D, GLN248C, GLU148C, GLU151C, GLU160C, GLU168D, GLU174D, GLU205C, GLU207D, GLU212C, GLU239D, GLU242D, GLU246C, GLU256C, GLU268C, GLU294C, GLU304C, GLU306C, GLU335D, GLU358D, GLU364D, GLU371D, GLU379D, GLY170D, GLY214C, GLY218D, GLY264C, GLY265C, GLY301C, GLY354D, ILE149C, ILE153C, ILE156C, ILE199D, ILE203D, ILE303C, ILE305C, ILE363D, LEU164C, LEU194D, LEU245C, LEU251C, LEU252C, LEU263C, LEU263D, LEU296C, LEU300C, LEU359D, LEU368D, LEU383D, LYS152C, LYS154C, LYS155C, LYS173D, LYS213C, LYS223D, LYS250C, LYS259C, LYS267C, LYS284C, LYS331D, LYS334D, LYS360D, PHE204D, PHE216C, PHE216D, PHE226D, PHE260C, PHE328D, PHE369D, PRO162C, PRO200D, PRO351D, SER157C, SER169D, SER198D, SER257C, SER370D, THR217D, TRP352D, TYR211D, TYR261C, TYR297C, TYR298C, TYR332D, TYR350D, TYR353D, VAL163C, VAL192D, VAL196D, VAL220D, VAL254C, VAL287C, VAL302C, VAL362D, VAL367D
• D-E: ALA159D, ALA193E, ALA197E, ALA206E, ALA215D, ALA219D, ALA219E, ALA230E, ALA247D, ALA249D, ALA333E, ALA366E, ARG178E, ARG186D, ARG201E, ARG253D, ARG262D, ARG266D, ARG274D, ARG281E, ARG293D, ARG299D, ARG357E, ARG365E, ASN195E, ASN272D, ASN280E, ASN361E, ASP185D, ASP238E, ASP295D, CYS158D, CYS161D, GLN248D, GLU151D, GLU160D, GLU174E, GLU205D, GLU205E, GLU207E, GLU212D, GLU224E, GLU228E, GLU239E, GLU242E, GLU246D, GLU256D, GLU268D, GLU294D, GLU304D, GLU358E, GLU364E, GLU371E, GLY170E, GLY210E, GLY214D, GLY218D, GLY218E, GLY225E, GLY264D, GLY265D, GLY301D, GLY354E, ILE153D, ILE156D, ILE199E, ILE203E, ILE255D, ILE303D, ILE305D, ILE363E, LEU194E, LEU208E, LEU229E, LEU245D, LEU251D, LEU252D, LEU263D, LEU296D, LEU300D, LEU368E, LEU383E, LYS152D, LYS154D, LYS155D, LYS213D, LYS213E, LYS223E, LYS250D, LYS259D, LYS267D, LYS331E, LYS334E, LYS360E, PHE191E, PHE204E, PHE209D, PHE209E, PHE216D, PHE216E, PHE226E, PHE227E, PHE236E, PHE260D, PHE328E, PHE369E, PRO162D, PRO200E, SER157D, SER169E, SER198E, SER221E, SER222E, SER244D, SER257D, SER370E, THR217D, THR217E, TYR211E, TYR261D, TYR298D, TYR332E, TYR350E, TYR353E, VAL163D, VAL192E, VAL196E, VAL220D, VAL220E, VAL254D, VAL302D, VAL362E
• D-J: ARG377J, GLU285D, GLU345J, LEU346J, LEU348J, LYS288D, LYS314J, SER349J, TYR350J
• E-F: ALA159E, ALA193F, ALA197F, ALA206F, ALA215E, ALA219E, ALA219F, ALA247E, ALA249E, ALA333F, ALA366F, ARG178F, ARG201F, ARG253E, ARG266E, ARG274E, ARG281F, ARG293E, ARG299E, ARG357F, ARG365F, ASN195F, ASN280F, ASN355F, ASN361F, ASP238F, ASP295E, CYS158E, CYS161E, CYS382F, GLN248E, GLU148E, GLU151E, GLU160E, GLU168F, GLU174F, GLU205E, GLU207F, GLU212E, GLU224F, GLU239F, GLU242F, GLU246E, GLU256E, GLU268E, GLU294E, GLU304E, GLU306E, GLU358F, GLU364F, GLU371F, GLU379F, GLY170F, GLY210F, GLY214E, GLY218F, GLY225F, GLY264E, GLY265E, GLY301E, GLY354F, ILE149E, ILE153E, ILE156E, ILE199F, ILE203F, ILE303E, ILE305E, ILE363F, LEU164E, LEU194F, LEU229F, LEU245E, LEU251E, LEU252E, LEU263E, LEU296E, LEU300E, LEU359F, LEU368F, LEU383F, LYS152E, LYS154E, LYS155E, LYS173F, LYS213E, LYS223F, LYS250E, LYS267E, LYS284E, LYS288E, LYS331F, LYS334F, LYS360F, PHE209E, PHE216E, PHE226F, PHE328F, PHE369F, PRO162E, PRO200F, PRO351F, SER157E, SER169F, SER198F, SER221F, SER222F, SER257E, SER370F, THR166E, THR217E, THR217F, TRP352F, TYR211E, TYR211F, TYR261E, TYR297E, TYR298E, TYR332F, TYR350F, TYR353F, VAL163E, VAL192F, VAL196F, VAL220F, VAL254E, VAL287E, VAL302E, VAL362F, VAL367F
• E-G: THR217E, THR217G
• E-I: ASN282I, GLU285I, GLU289E, LYS288E, LYS288I
• E-J: ARG377J, TYR353E
• F-G: ALA159F, ALA193G, ALA197G, ALA206F, ALA206G, ALA215F, ALA219F, ALA219G, ALA230G, ALA247F, ALA249F, ALA333G, ALA366G, ARG178G, ARG186F, ARG201F, ARG201G, ARG253F, ARG262F, ARG262G, ARG266F, ARG274F, ARG293F, ARG299F, ARG357G, ARG365G, ASN195G, ASN272F, ASN280G, ASN355G, ASN361G, ASP202F, ASP202G, ASP238G, ASP295F, CYS158F, CYS161F, GLN248F, GLU151F, GLU160F, GLU168G, GLU174G, GLU205F, GLU207G, GLU212F, GLU224G, GLU228G, GLU239G, GLU242G, GLU246F, GLU256F, GLU268F, GLU294F, GLU304F, GLU358G, GLU364G, GLU371G, GLY170G, GLY210G, GLY214F, GLY218F, GLY218G, GLY225G, GLY264F, GLY265F, GLY301F, GLY354G, ILE153F, ILE156F, ILE199G, ILE203G, ILE255F, ILE303F, ILE305F, ILE363G, LEU194G, LEU208G, LEU229G, LEU245F, LEU251F, LEU252F, LEU263F, LEU296F, LEU300F, LEU359G, LEU368G, LEU383G, LYS152F, LYS155F, LYS173G, LYS213F, LYS223G, LYS250F, LYS259F, LYS267F, LYS327G, LYS331G, LYS334G, LYS360G, PHE191G, PHE204G, PHE209F, PHE209G, PHE216F, PHE216G, PHE226G, PHE227G, PHE236G, PHE260F, PHE328G, PHE369G, PRO162F, PRO190G, PRO200G, SER157F, SER169G, SER198G, SER221F, SER221G, SER222G, SER244F, SER257F, SER370G, THR217F, THR217G, TRP352G, TYR211G, TYR261F, TYR297F, TYR298F, TYR332G, TYR350G, TYR353G, VAL163F, VAL192G, VAL196G, VAL220F, VAL220G, VAL254F, VAL302F, VAL362G, VAL367G
• F-H: ARG311F, ARG313F, GLU168F, GLU285H, GLU306F, GLU312F, GLU315F, GLY167F, ILE307F, LYS145F, LYS284H, LYS288H, LYS314F, PRO144F, PRO308F, PRO309F
• F-I: ALA343F, ARG311F, ARG311I, ARG377F, ARG377I, CYS382I, GLN344F, GLU345F, GLU345I, LEU346F, LEU346I, LEU347I, LEU348F, LEU348I, LYS314F, LYS314I, LYS341F, PRO351F, PRO351I, SER342F, SER349F, SER349I, SER381F, SER381I, THR340F, TRP352F, TRP352I, TYR350F, TYR350I, TYR353F, TYR353I, VAL384F, VAL384I
• G-K: GLU285K, GLU289K, LYS288G
• G-M: LYS291M, LYS314G
• G-N: ALA343G, ARG377G, ASP376G, GLU285N, GLU289N, GLU345G, GLU379G, GLY290N, GLY378G, LEU286N, LEU346G, LYS288N, LYS291N, LYS341G, SER342G, SER381G, THR340G
• H-I: ALA159H, ALA193I, ALA197I, ALA206I, ALA215H, ALA219H, ALA219I, ALA230I, ALA247H, ALA249H, ALA333I, ALA366I, ARG178I, ARG186H, ARG201I, ARG253H, ARG262H, ARG262I, ARG266H, ARG274H, ARG281I, ARG293H, ARG299H, ARG357I, ARG365I, ASN195I, ASN272H, ASN280I, ASN361I, ASP238I, ASP295H, CYS158H, CYS161H, GLN248H, GLU151H, GLU160H, GLU174I, GLU205H, GLU205I, GLU207I, GLU212H, GLU224I, GLU228I, GLU239I, GLU242I, GLU246H, GLU256H, GLU268H, GLU294H, GLU304H, GLU358I, GLU364I, GLU371I, GLY170I, GLY210I, GLY214H, GLY214I, GLY218H, GLY218I, GLY225I, GLY264H, GLY265H, GLY301H, GLY354I, ILE153H, ILE156H, ILE199I, ILE203I, ILE255H, ILE303H, ILE305H, ILE363I, LEU194I, LEU208I, LEU229I, LEU235I, LEU245H, LEU251H, LEU252H, LEU263H, LEU296H, LEU300H, LEU368I, LEU383I, LYS152H, LYS154H, LYS155H, LYS213H, LYS213I, LYS223I, LYS250H, LYS259H, LYS267H, LYS327I, LYS331I, LYS334I, LYS360I, PHE191I, PHE204I, PHE209H, PHE209I, PHE216H, PHE216I, PHE226I, PHE227I, PHE236I, PHE260H, PHE328I, PHE369I, PRO162H, PRO200I, SER157H, SER169I, SER198I, SER221I, SER222I, SER244H, SER257H, SER370I, THR217H, THR217I, TYR211H, TYR211I, TYR261H, TYR298H, TYR332I, TYR350I, TYR353I, VAL163H, VAL192I, VAL196I, VAL220H, VAL220I, VAL302H, VAL362I, VAL367I
• H-M: LYS213M, VAL220H
• H-N: ALA159N, ALA193H, ALA197H, ALA206H, ALA206N, ALA215N, ALA219H, ALA219N, ALA230H, ALA247N, ALA249N, ALA366H, ARG178H, ARG201H, ARG201N, ARG253N, ARG262H, ARG262N, ARG266N, ARG274N, ARG281H, ARG293N, ARG299N, ARG357H, ARG365H, ASN195H, ASN280H, ASN355H, ASN361H, ASP202H, ASP202N, ASP238H, ASP295N, CYS158N, CYS161N, GLN248N, GLU160N, GLU174H, GLU205N, GLU207H, GLU212N, GLU224H, GLU228H, GLU239H, GLU242H, GLU246N, GLU256N, GLU268N, GLU294N, GLU304N, GLU358H, GLU364H, GLY170H, GLY210H, GLY214N, GLY218H, GLY218N, GLY225H, GLY264N, GLY265N, GLY301N, GLY354H, ILE156N, ILE199H, ILE203H, ILE255N, ILE303N, ILE363H, LEU194H, LEU208H, LEU229H, LEU235H, LEU245N, LEU251N, LEU252N, LEU263N, LEU296N, LEU300N, LEU368H, LYS152N, LYS155N, LYS213H, LYS213N, LYS223H, LYS250N, LYS259N, LYS267N, LYS331H, LYS360H, PHE191H, PHE204H, PHE209H, PHE209N, PHE216H, PHE216N, PHE226H, PHE227H, PHE236H, PHE260N, PHE328H, PHE369H, PRO162N, PRO190H, PRO200H, PRO351H, SER157N, SER169H, SER198H, SER221H, SER221N, SER222H, SER222N, SER244N, SER257N, THR217H, THR217N, TRP352H, TYR211H, TYR211N, TYR261N, TYR297N, TYR298N, TYR332H, TYR353H, VAL192H, VAL196H, VAL220H, VAL220N, VAL254N, VAL302N, VAL362H
• I-J: ALA159I, ALA193J, ALA197J, ALA206J, ALA219J, ALA249I, ALA366J, ARG253I, ARG262I, ARG266I, ARG274I, ARG281J, ARG293I, ARG299I, ARG311J, ARG357J, ARG365J, ASN195J, ASN280J, ASN355J, ASN361J, ASP185I, ASP202J, ASP238J, ASP295I, CYS158I, CYS161I, CYS382J, GLU151I, GLU160I, GLU168J, GLU207J, GLU239J, GLU242J, GLU256I, GLU268I, GLU294I, GLU304I, GLU306I, GLU358J, GLU364J, GLU371J, GLU379J, GLY218J, GLY264I, GLY265I, GLY301I, GLY354J, GLY372J, ILE149I, ILE153I, ILE156I, ILE199J, ILE203J, ILE255I, ILE303I, ILE305I, ILE363J, LEU164I, LEU194J, LEU252I, LEU263I, LEU300I, LEU359J, LEU368J, LEU383J, LYS152I, LYS154I, LYS155I, LYS213I, LYS223J, LYS250I, LYS259I, LYS267I, LYS284I, LYS288I, LYS331J, LYS334J, LYS360J, PHE204J, PHE216J, PHE226J, PHE260I, PHE328J, PHE369J, PRO162I, PRO200J, PRO351J, SER157I, SER169J, SER198J, SER257I, SER370J, THR217J, TRP352J, TYR211J, TYR261I, TYR297I, TYR298I, TYR332J, TYR350J, TYR353J, VAL163I, VAL196J, VAL220J, VAL302I, VAL362J, VAL367J, VAL384J
• I-M: GLY214M, THR217I, THR217M
• I-N: ALA219I, GLY218I, THR217I, THR217N
• J-K: ALA159J, ALA193K, ALA197K, ALA206K, ALA215J, ALA219K, ALA230K, ALA247J, ALA249J, ALA366K, ARG178K, ARG201K, ARG253J, ARG262J, ARG262K, ARG266J, ARG274J, ARG293J, ARG299J, ARG357K, ARG365K, ASN195K, ASN280K, ASN355K, ASN361K, ASP202K, ASP238K, ASP295J, CYS158J, CYS161J, GLN248J, GLU151J, GLU160J, GLU174K, GLU205J, GLU207K, GLU212J, GLU224K, GLU228K, GLU239K, GLU242K, GLU246J, GLU256J, GLU268J, GLU294J, GLU304J, GLU358K, GLU364K, GLU371K, GLY170K, GLY210K, GLY214J, GLY214K, GLY218J, GLY218K, GLY225K, GLY264J, GLY265J, GLY301J, GLY354K, ILE156J, ILE199K, ILE203K, ILE255J, ILE303J, ILE305J, ILE363K, LEU164J, LEU194K, LEU208K, LEU229K, LEU245J, LEU251J, LEU252J, LEU263J, LEU296J, LEU300J, LEU359K, LEU368K, LEU383K, LYS152J, LYS155J, LYS173K, LYS213J, LYS213K, LYS223K, LYS250J, LYS259J, LYS267J, LYS327K, LYS331K, LYS334K, LYS360K, PHE191K, PHE204K, PHE209J, PHE209K, PHE216J, PHE216K, PHE226K, PHE227K, PHE236K, PHE328K, PHE369K, PRO162J, PRO200K, SER157J, SER169K, SER198K, SER221K, SER222K, SER244J, SER257J, SER370K, THR217J, THR217K, TRP352K, TYR211K, TYR261J, TYR297J, TYR298J, TYR332K, TYR350K, TYR353K, VAL163J, VAL192K, VAL196K, VAL220J, VAL220K, VAL302J, VAL362K
• J-L: THR217J, VAL220L
• K-L: ALA159K, ALA193L, ALA197L, ALA206L, ALA215K, ALA219K, ALA219L, ALA230L, ALA247K, ALA249K, ALA333L, ALA366L, ARG178L, ARG201L, ARG253K, ARG262K, ARG262L, ARG266K, ARG274K, ARG293K, ARG299K, ARG357L, ARG365L, ASN195L, ASN280L, ASN355L, ASN361L, ASP202K, ASP202L, ASP238L, ASP295K, CYS158K, CYS161K, CYS382L, GLN248K, GLU151K, GLU160K, GLU174L, GLU205K, GLU207L, GLU212K, GLU224L, GLU228L, GLU239L, GLU242L, GLU246K, GLU256K, GLU268K, GLU294K, GLU304K, GLU358L, GLU364L, GLU371L, GLY210L, GLY214K, GLY218K, GLY218L, GLY225L, GLY264K, GLY265K, GLY301K, GLY354L, ILE153K, ILE156K, ILE199L, ILE203L, ILE255K, ILE303K, ILE305K, ILE363L, LEU194L, LEU208L, LEU229L, LEU235L, LEU245K, LEU251K, LEU252K, LEU263K, LEU296K, LEU300K, LEU359L, LEU368L, LEU383L, LYS152K, LYS155K, LYS213K, LYS223L, LYS250K, LYS259K, LYS267K, LYS331L, LYS360L, PHE191L, PHE204L, PHE209K, PHE209L, PHE216K, PHE216L, PHE226L, PHE227L, PHE236L, PHE260K, PHE328L, PHE369L, PRO162K, PRO190L, PRO200L, SER169L, SER198L, SER221L, SER222L, SER244K, SER257K, SER370L, THR217K, THR217L, TRP352L, TYR211L, TYR261K, TYR297K, TYR298K, TYR332L, TYR350L, TYR353L, VAL163K, VAL192L, VAL196L, VAL220K, VAL220L, VAL254K, VAL302K, VAL362L, VAL367L
• K-M: GLY218M, THR217K, THR217M
• L-M: ALA159L, ALA193M, ALA197M, ALA206M, ALA215L, ALA219L, ALA219M, ALA230M, ALA247L, ALA249L, ALA333M, ALA366M, ARG178M, ARG186L, ARG201M, ARG253L, ARG262L, ARG262M, ARG266L, ARG274L, ARG293L, ARG299L, ARG357M, ARG365M, ASN195M, ASN272L, ASN280M, ASN355M, ASN361M, ASP185L, ASP202L, ASP238M, ASP295L, CYS158L, CYS161L, GLN248L, GLU151L, GLU160L, GLU168M, GLU174M, GLU205L, GLU205M, GLU207M, GLU212L, GLU224M, GLU228M, GLU239M, GLU242M, GLU246L, GLU256L, GLU268L, GLU294L, GLU304L, GLU358M, GLU364M, GLU371M, GLY170M, GLY210M, GLY214L, GLY218L, GLY218M, GLY225M, GLY264L, GLY265L, GLY301L, GLY354M, ILE149L, ILE153L, ILE156L, ILE199M, ILE203M, ILE255L, ILE303L, ILE305L, ILE363M, LEU194M, LEU208M, LEU229M, LEU235M, LEU245L, LEU251L, LEU252L, LEU263L, LEU296L, LEU300L, LEU359M, LEU368M, LEU383M, LYS152L, LYS154L, LYS155L, LYS173M, LYS213L, LYS223M, LYS250L, LYS259L, LYS267L, LYS284L, LYS331M, LYS334M, LYS360M, PHE191M, PHE204M, PHE209L, PHE209M, PHE216L, PHE216M, PHE226M, PHE227M, PHE236M, PHE260L, PHE328M, PHE369M, PRO162L, PRO190M, PRO200M, PRO351M, SER157L, SER169M, SER198M, SER221M, SER222L, SER222M, SER244L, SER257L, SER370M, THR217L, THR217M, TRP352M, TYR211M, TYR261L, TYR297L, TYR298L, TYR332M, TYR350M, TYR353M, VAL163L, VAL192M, VAL196M, VAL220L, VAL220M, VAL254L, VAL302L, VAL356M, VAL362M, VAL367M, VAL384M
• M-N: ALA159M, ALA193N, ALA197N, ALA206N, ALA219N, ALA249M, ALA333N, ALA366N, ARG253M, ARG262M, ARG266M, ARG274M, ARG281N, ARG293M, ARG299M, ARG357N, ARG365N, ASN195N, ASN280N, ASN355N, ASN361N, ASP185M, ASP202N, ASP238N, ASP295M, CYS158M, CYS161M, CYS382N, GLU148M, GLU151M, GLU160M, GLU174N, GLU205N, GLU207N, GLU212M, GLU239N, GLU242N, GLU256M, GLU268M, GLU294M, GLU304M, GLU358N, GLU364N, GLU371N, GLY214M, GLY218N, GLY264M, GLY265M, GLY301M, GLY354N, ILE149M, ILE153M, ILE156M, ILE199N, ILE203N, ILE255M, ILE303M, ILE305M, ILE363N, LEU164M, LEU194N, LEU208N, LEU252M, LEU263M, LEU296M, LEU300M, LEU359N, LEU368N, LEU383N, LYS152M, LYS154M, LYS155M, LYS213M, LYS223N, LYS250M, LYS259M, LYS267M, LYS284M, LYS331N, LYS334N, LYS360N, PHE204N, PHE216N, PHE226N, PHE260M, PHE328N, PHE369N, PRO162M, PRO200N, PRO351N, SER157M, SER169N, SER198N, SER221N, SER257M, SER370N, THR217N, TRP352N, TYR211N, TYR261M, TYR297M, TYR298M, TYR332N, TYR350N, TYR353N, VAL163M, VAL192N, VAL196N, VAL220N, VAL254M, VAL302M, VAL362N, VAL367N, VAL384N