1NVU

structural evidence for feedback activation by rasgtp of the ras-specific nucleotide exchange factor sos

• Total interactions analyzed: 3
• Total true interactions: 2
• Strongest Interaction:
  • Chains: Q-S
  • Int. Res.: 150
  • Norm. En. per Res.: -3.8512
• Hub Node: Q(1)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
Q-S	-51.297	-123.5179	-402.87	-577.6849	150	17	3	15826	10	62	29
R-S	-84.4328	-82.9659	-450.227	-617.6257	170	17	2	17247	12	89	82

Interface residues

• Q-S: ALA146Q, ALA619S, ALA66Q, ALA725S, ALA917S, ARG149Q, ARG41Q, ARG625S, ARG676S, ARG678S, ARG688S, ARG68Q, ARG694S, ARG739S, ARG73Q, ARG797S, ARG920S, ASN26Q, ASN622S, ASN691S, ASN751S, ASN866S, ASN923S, ASN976S, ASP154Q, ASP30Q, ASP33Q, ASP38Q, ASP54Q, ASP57Q, ASP620S, ASP69Q, CYS51Q, CYS693S, CYS926S, CYS980S, GLN150Q, GLN22Q, GLN25Q, GLN43Q, GLN61Q, GLN683S, GLN686S, GLN70Q, GLN755S, GLN972S, GLN973S, GLN975S, GLN977S, GLU153Q, GLU31Q, GLU37Q, GLU3Q, GLU49Q, GLU62Q, GLU63Q, GLU680S, GLU698S, GLU731S, GLU966S, GLU970S, GLY12Q, GLY151Q, GLY48Q, GLY597S, GLY59Q, GLY60Q, GLY969S, HIS27Q, HIS616S, HIS695S, HIS699S, HIS750S, ILE21Q, ILE24Q, ILE36Q, ILE46Q, ILE55Q, ILE598S, ILE733S, ILE736S, ILE752S, ILE922S, LEU23Q, LEU52Q, LEU53Q, LEU56Q, LEU613S, LEU687S, LEU690S, LEU916S, LEU919S, LYS147Q, LYS42Q, LYS5Q, LYS679S, LYS724S, LYS727S, LYS728S, LYS735S, LYS918S, MET1Q, MET617S, MET67Q, MET726S, PHE28Q, PHE623S, PHE754S, PHE868S, PRO34Q, PRO621S, PRO684S, PRO924S, PRO925S, PRO978S, SER145Q, SER17Q, SER39Q, SER65Q, SER732S, SER756S, SER921S, THR148Q, THR2Q, THR35Q, THR50Q, THR58Q, THR614S, THR74Q, THR753S, TRP729S, TYR157Q, TYR32Q, TYR40Q, TYR615S, TYR618S, TYR64Q, TYR681S, TYR71Q, TYR974S, TYR979S, VAL152Q, VAL29Q, VAL44Q, VAL45Q, VAL624S, VAL685S, VAL689S, VAL692S, VAL730S
• R-S: ALA11R, ALA146R, ALA18R, ALA603S, ALA66R, ALA877S, ALA904S, ARG1019S, ARG102R, ARG41R, ARG68R, ARG73R, ARG826S, ARG885S, ARG950S, ARG962S, ASN1011S, ASN116R, ASN26R, ASN830S, ASN869S, ASN86R, ASN879S, ASN936S, ASN944S, ASN957S, ASP1007S, ASP105R, ASP107R, ASP30R, ASP33R, ASP38R, ASP54R, ASP57R, ASP69R, ASP910S, CYS118R, GLN22R, GLN25R, GLN61R, GLN70R, GLN95R, GLN99R, GLU1002S, GLU1004S, GLU31R, GLU37R, GLU3R, GLU589S, GLU590S, GLU62R, GLU63R, GLU812S, GLU815S, GLU836S, GLU873S, GLU906S, GLU909S, GLU941S, GLU942S, GLU966S, GLU970S, GLU98R, GLY12R, GLY13R, GLY15R, GLY59R, GLY60R, GLY931S, GLY943S, HIS827S, HIS905S, HIS911S, HIS94R, ILE100R, ILE21R, ILE24R, ILE36R, ILE55R, ILE587S, ILE600S, ILE601S, ILE825S, ILE932S, ILE937S, ILE967S, LEU1009S, LEU1014S, LEU19R, LEU53R, LEU56R, LEU6R, LEU821S, LEU822S, LEU831S, LEU833S, LEU872S, LEU907S, LEU916S, LEU934S, LEU938S, LEU948S, LYS1003S, LYS101R, LYS104R, LYS147R, LYS16R, LYS5R, LYS602S, LYS811S, LYS814S, LYS913S, LYS939S, LYS949S, LYS960S, LYS963S, MET67R, MET72R, MET824S, MET878S, PHE1005S, PHE1010S, PHE929S, PHE930S, PHE958S, PRO34R, PRO882S, PRO928S, PRO945S, SER1013S, SER17R, SER39R, SER65R, SER807S, SER818S, SER876S, SER880S, SER881S, SER908S, SER959S, THR1006S, THR20R, THR35R, THR58R, THR74R, THR810S, THR828S, THR829S, THR832S, THR935S, THR940S, TRP809S, TRP834S, TYR1008S, TYR32R, TYR40R, TYR64R, TYR71R, TYR796S, TYR884S, TYR912S, TYR933S, VAL103R, VAL14R, VAL29R, VAL7R, VAL874S, VAL875S, VAL883S, VAL964S