1NF6

x-ray structure of the desulfovibrio desulfuricans bacterioferritin: the diiron site in different catalytic states ("cycled" structure: reduced in solution and allowed to reoxidise before crystallisation)

• Total interactions analyzed: 120
• Total true interactions: 33
• Strongest Interaction:
  • Chains: F-P
  • Int. Res.: 50
  • Norm. En. per Res.: -3.6504
• Hub Node: B(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-67.0284	-33.3507	-384.941	-485.3201	159	20	10	15794	4	48	53
A-N	-26.4509	-12.6042	-78.7166	-117.7717	39	7	5	3185	2	13	7
A-O	0.0	23.0387	-25.2599	-2.2212	18	1	0	1018	0	19	22
B-C	0.0	0.0	-1.834	-1.834	9	0	0	162	0	9	4
B-E	0.0	-0.9319	-3.0183	-3.9502	8	0	0	315	0	2	2
B-G	-17.5596	-57.1544	-82.4005	-157.1145	46	2	3	3870	12	29	33
B-H	-7.881	-7.8774	-84.6317	-100.3901	40	6	5	3309	2	13	7
B-N	-10.3062	-55.0515	-79.0327	-144.3903	46	1	3	3839	8	30	31
B-P	0.0	-10.2308	-14.1745	-24.4053	23	1	0	800	1	4	5
C-D	-53.3364	-25.3596	-400.117	-478.813	157	16	10	15727	4	48	51
C-E	-39.2517	-11.3553	-83.6525	-134.2595	39	8	5	3309	1	14	7
C-G	-13.0943	9.0639	-30.6798	-34.7101	20	2	1	1102	0	12	12
C-P	0.0	0.0	-0.3977	-0.3977	4	0	0	83	0	1	2
D-E	-17.1606	-63.9826	-74.6657	-155.8089	46	3	3	3517	7	30	30
E-F	-49.2715	-21.4866	-378.528	-449.2861	156	25	8	15458	4	49	51
E-H	0.0	15.2059	-4.2205	10.9855	21	0	0	441	0	2	3
E-P	-3.0318	-12.6445	-76.2517	-91.928	39	6	4	3115	2	13	7
F-K	-15.2471	-59.2128	-75.5001	-149.96	48	0	3	3596	8	30	31
F-L	-2.3166	-6.2371	-89.2181	-97.7718	40	4	5	3461	2	14	7
F-P	-27.1941	-83.8397	-71.4886	-182.5224	50	3	3	3499	11	30	31
G-H	-70.6616	-21.1209	-390.391	-482.1735	160	14	8	15755	4	47	54
G-I	-27.2462	-12.1784	-84.7657	-124.1903	41	9	5	3482	1	14	7
G-M	-36.1753	-10.5361	-82.5775	-129.2889	38	8	5	3211	1	13	7
G-N	-24.569	-54.7197	-81.7484	-161.0371	47	6	3	3885	12	30	33
H-I	-21.7801	-61.3412	-77.2183	-160.3396	46	5	3	3667	12	31	32
H-P	0.0	0.0	-0.0266	-0.0266	4	0	0	14	0	2	1
I-J	-61.0969	-24.7055	-383.691	-469.4934	157	17	8	15630	5	48	52
I-M	0.0	0.0	-0.1174	-0.1174	4	0	0	44	0	0	1
K-L	-63.5062	-26.4256	-382.71	-472.6418	157	15	10	15422	4	48	53
K-O	-25.8231	-9.8228	-79.5683	-115.2142	40	8	5	3301	1	14	7
K-P	-8.2101	-66.746	-82.0642	-157.0202	48	3	3	3900	12	32	32
M-N	-60.2906	-19.1575	-384.25	-463.6981	159	13	9	15703	4	48	52
O-P	-44.9515	-27.185	-382.714	-454.8505	158	13	10	15439	4	46	53

Interface residues

• A-B: ALA134A, ALA134B, ALA167A, ALA167B, ALA47A, ALA47B, ALA53A, ALA53B, ALA60A, ALA60B, ALA64A, ALA64B, ARG127A, ARG127B, ARG20A, ARG20B, ARG58A, ARG58B, ASN141A, ASN141B, ASN32A, ASN32B, ASN48A, ASN48B, ASN62A, ASN62B, ASP38A, ASP38B, ASP39A, ASP39B, ASP55A, ASP55B, GLN133A, GLN133B, GLN29A, GLN29B, GLN33A, GLN33B, GLN77A, GLN77B, GLN86A, GLN86B, GLU130A, GLU130B, GLU131A, GLU131B, GLU132A, GLU132B, GLU44A, GLU44B, GLU56A, GLU56B, GLU61A, GLU61B, GLU65A, GLU65B, GLU69A, GLU69B, GLU73A, GLU73B, GLY165A, GLY165B, GLY170A, GLY170B, GLY71A, GLY71B, GLY72A, GLY72B, GLY80B, GLY85A, GLY85B, HIS135A, HIS135B, HIS25A, HIS25B, HIS28A, HIS28B, HIS34A, HIS34B, HIS59A, HIS59B, ILE128A, ILE128B, ILE142A, ILE142B, ILE27A, ILE27B, ILE52A, ILE52B, ILE54A, ILE54B, ILE67A, ILE67B, ILE91A, ILE91B, LEU136A, LEU136B, LEU24A, LEU24B, LEU37A, LEU37B, LEU51A, LEU51B, LEU70A, LEU70B, LYS169A, LYS169B, LYS50A, LYS50B, LYS68A, LYS68B, LYS78A, LYS78B, LYS81A, LYS81B, MET31A, MET31B, MET40A, MET40B, MET49A, MET49B, MET57A, MET57B, PHE171A, PHE171B, PHE63A, PHE63B, PRO74A, PRO74B, SER162B, SER163A, SER168A, SER168B, SER36A, SER36B, THR137A, THR137B, THR164A, THR164B, THR166A, THR166B, THR75A, THR75B, THR76A, THR76B, THR84A, THR84B, TYR138A, TYR138B, TYR139A, TYR139B, TYR35A, TYR35B, VAL172A, VAL172B, VAL82A, VAL82B, VAL83A, VAL83B
• A-N: ALA155A, ALA155N, ALA158A, ASN141N, ASN148N, ASP151A, ASP151N, ASP38A, ASP39A, ASP41A, GLU140N, GLU44N, GLY150A, GLY150N, GLY159A, GLY43A, HIS145N, ILE142N, ILE146N, ILE157A, ILE157N, LEU149A, LEU149N, LEU154A, LEU154N, LEU37A, LYS156A, LYS156N, MET40A, PRO161A, SER144N, THR137N, THR152A, THR152N, THR160A, TYR138N, TYR153A, TYR153N, TYR42A
• A-O: ALA10A, ALA10O, ARG5A, ARG5O, ARG8A, ARG8O, ASN4A, ASP7A, ASP7O, GLU6A, GLU6O, GLY3A, ILE13A, ILE13O, LYS11A, LYS11O, LYS9A, LYS9O
• B-C: ASN148B, ASN148C, ASP151C, ASP97B, GLU93B, LEU149C, LYS147B, LYS147C, THR152C
• B-E: ALA155E, ASN148B, ASP151E, GLY150E, LEU149B, LEU149E, LYS147B, THR152E
• B-G: ALA101B, ALA105B, ALA122B, ALA122G, ALA134B, ARG123B, ARG123G, ARG127B, ARG127G, ARG5G, ARG66G, ARG8G, ASN141B, ASP100B, ASP118G, GLN108B, GLN116G, GLN133B, GLU104B, GLU126B, GLU126G, GLU130B, GLU131B, GLU132B, GLU140B, GLU69G, GLY117G, ILE103B, ILE119G, ILE128B, ILE129B, LEU110B, LEU124G, LEU136B, LEU70G, LYS111B, LYS114B, LYS114G, LYS9G, PHE125B, SER107B, THR102B, THR121G, THR137B, TYR106B, VAL120G
• B-H: ALA155B, ALA155H, ALA158H, ASN141B, ASN148B, ASP151B, ASP151H, ASP38H, ASP39H, ASP41H, GLU140B, GLU44B, GLU44H, GLY150B, GLY150H, GLY159H, GLY43H, HIS145B, ILE142B, ILE146B, ILE157B, ILE157H, LEU149B, LEU149H, LEU154B, LEU154H, LEU37H, LYS156B, LYS156H, MET40H, PRO161H, SER144B, THR137B, THR152B, THR152H, THR160H, TYR138B, TYR153B, TYR153H, TYR42H
• B-N: ALA101N, ALA122B, ALA122N, ALA134N, ARG123B, ARG123N, ARG127B, ARG127N, ARG5B, ARG66B, ARG8B, ASN141N, ASP100N, ASP118B, ASP97N, GLN108N, GLN116B, GLN133N, GLU104N, GLU126B, GLU126N, GLU130N, GLU131N, GLU132N, GLU140N, GLU69B, GLY117B, ILE103N, ILE119B, ILE128N, ILE129N, LEU110B, LEU110N, LEU124B, LEU136N, LEU70B, LYS111N, LYS114B, LYS114N, LYS9B, PHE125N, SER107N, THR121B, THR137N, TYR106N, VAL120B
• B-P: ALA155B, ALA155P, ALA87B, ASN148B, ASN148P, ASP151B, ASP151P, GLY150B, GLY150P, ILE146B, ILE146P, LEU149B, LEU149P, LEU154B, LYS147B, LYS147P, PRO89B, PRO89P, THR152B, THR152P, TYR153P, VAL88B, VAL90B
• C-D: ALA134C, ALA134D, ALA167C, ALA167D, ALA47C, ALA47D, ALA53C, ALA53D, ALA60C, ALA60D, ALA64C, ALA64D, ARG127C, ARG127D, ARG20C, ARG20D, ARG58C, ARG58D, ARG66D, ASN141C, ASN141D, ASN32C, ASN32D, ASN48C, ASN48D, ASN62C, ASN62D, ASP38C, ASP38D, ASP39C, ASP39D, ASP55C, ASP55D, GLN133C, GLN133D, GLN29C, GLN29D, GLN33C, GLN33D, GLN77C, GLN77D, GLN86C, GLN86D, GLU130C, GLU130D, GLU131C, GLU131D, GLU132C, GLU132D, GLU44C, GLU44D, GLU56C, GLU56D, GLU61C, GLU61D, GLU65C, GLU65D, GLU69C, GLU69D, GLU73C, GLU73D, GLY165C, GLY165D, GLY170C, GLY170D, GLY71C, GLY71D, GLY72C, GLY72D, GLY85C, GLY85D, HIS135C, HIS135D, HIS25C, HIS25D, HIS28C, HIS28D, HIS34C, HIS34D, HIS59C, HIS59D, ILE128C, ILE128D, ILE142C, ILE142D, ILE27C, ILE27D, ILE52C, ILE52D, ILE54C, ILE54D, ILE67C, ILE67D, ILE91C, LEU136C, LEU136D, LEU24C, LEU24D, LEU37C, LEU37D, LEU45D, LEU51C, LEU51D, LEU70C, LEU70D, LYS169C, LYS169D, LYS50C, LYS50D, LYS68C, LYS68D, LYS78C, LYS78D, LYS81C, LYS81D, MET31C, MET31D, MET40C, MET40D, MET49C, MET49D, MET57C, MET57D, PHE171C, PHE171D, PHE63C, PHE63D, PRO74C, PRO74D, SER168C, SER168D, SER36C, SER36D, THR137C, THR137D, THR164C, THR164D, THR166C, THR166D, THR75C, THR75D, THR76C, THR76D, THR84C, THR84D, TYR138C, TYR138D, TYR139C, TYR139D, TYR35C, TYR35D, VAL172C, VAL172D, VAL82C, VAL82D, VAL83C, VAL83D
• C-E: ALA155C, ALA155E, ALA158C, ASN141E, ASN148E, ASP151C, ASP151E, ASP38C, ASP39C, ASP41C, GLU140E, GLU44E, GLY150C, GLY150E, GLY159C, GLY43C, HIS145E, ILE142E, ILE146E, ILE157C, ILE157E, LEU149C, LEU149E, LEU154C, LEU154E, LEU37C, LYS156C, LYS156E, MET40C, PRO161C, SER144E, THR137E, THR152C, THR152E, THR160C, TYR138E, TYR153C, TYR153E, TYR42C
• C-G: ALA10G, ALA87C, ARG5G, ARG8G, ASN4G, ASP7G, ASP97C, GLU6G, GLU93C, GLY143C, ILE146C, ILE91C, LYS11G, LYS147C, LYS9G, PRO89C, SER94C, TYR92C, VAL88C, VAL90C
• C-P: ALA155C, ALA155P, THR152C, THR152P
• D-E: ALA101E, ALA105E, ALA122D, ALA122E, ALA134E, ARG123D, ARG123E, ARG127D, ARG127E, ARG5D, ARG66D, ARG8D, ASN141E, ASP100E, ASP118D, ASP97E, GLN108E, GLN116D, GLN133E, GLU104E, GLU126D, GLU126E, GLU130E, GLU131E, GLU132E, GLU140E, GLU69D, GLY117D, ILE103E, ILE119D, ILE129E, LEU110D, LEU110E, LEU124D, LEU136E, LEU70D, LYS111E, LYS114D, LYS114E, LYS9D, PHE125E, SER107E, THR121D, THR137E, TYR106E, VAL120D
• E-F: ALA134E, ALA134F, ALA167E, ALA167F, ALA21E, ALA47E, ALA47F, ALA53E, ALA53F, ALA60E, ALA60F, ALA64E, ALA64F, ARG127E, ARG127F, ARG20E, ARG20F, ARG58E, ARG58F, ASN141E, ASN141F, ASN32E, ASN32F, ASN48E, ASN48F, ASN62E, ASN62F, ASP38E, ASP38F, ASP39E, ASP39F, ASP55E, ASP55F, GLN133E, GLN133F, GLN29E, GLN29F, GLN33E, GLN33F, GLN77E, GLN77F, GLN86E, GLN86F, GLU130E, GLU130F, GLU131E, GLU131F, GLU132E, GLU132F, GLU44E, GLU56E, GLU56F, GLU61E, GLU61F, GLU65E, GLU65F, GLU69E, GLU69F, GLU73E, GLU73F, GLY165E, GLY165F, GLY170E, GLY170F, GLY71E, GLY71F, GLY72E, GLY72F, GLY80F, GLY85E, GLY85F, HIS135E, HIS135F, HIS25E, HIS25F, HIS28E, HIS28F, HIS34E, HIS34F, HIS59E, HIS59F, ILE128E, ILE128F, ILE142E, ILE142F, ILE27E, ILE27F, ILE52E, ILE52F, ILE54E, ILE54F, ILE67E, ILE67F, LEU136E, LEU136F, LEU24E, LEU24F, LEU37E, LEU37F, LEU51E, LEU51F, LEU70E, LEU70F, LYS169E, LYS169F, LYS50E, LYS50F, LYS68E, LYS68F, LYS78E, LYS78F, LYS81E, LYS81F, MET31E, MET31F, MET40E, MET40F, MET49E, MET49F, MET57E, MET57F, PHE171E, PHE171F, PHE63E, PHE63F, PRO74E, PRO74F, SER162F, SER168E, SER168F, SER36E, SER36F, THR137E, THR137F, THR164E, THR164F, THR166E, THR166F, THR75E, THR75F, THR76E, THR76F, THR84E, THR84F, TYR138E, TYR138F, TYR139E, TYR139F, TYR35E, TYR35F, VAL172E, VAL172F, VAL82E, VAL82F, VAL83E, VAL83F
• E-H: ALA87E, ALA87H, ASP151E, ASP151H, GLN86E, GLN86H, GLU93E, GLU93H, GLY85E, GLY85H, LYS147E, LYS147H, PRO89E, PRO89H, THR84E, THR84H, VAL83E, VAL83H, VAL88H, VAL90E, VAL90H
• E-P: ALA155E, ALA155P, ALA158E, ASN141P, ASN148P, ASP151E, ASP151P, ASP38E, ASP39E, ASP41E, GLU140P, GLU44P, GLY150E, GLY150P, GLY159E, GLY43E, HIS145P, ILE142P, ILE146P, ILE157E, ILE157P, LEU149E, LEU149P, LEU154E, LEU154P, LEU37E, LYS156E, LYS156P, MET40E, PRO161E, SER144P, THR137P, THR152E, THR152P, THR160E, TYR138P, TYR153E, TYR153P, TYR42E
• F-K: ALA101F, ALA105F, ALA122F, ALA122K, ALA134F, ARG123F, ARG123K, ARG127F, ARG127K, ARG5K, ARG66K, ARG8K, ASN141F, ASP100F, ASP118K, ASP97F, GLN108F, GLN116K, GLN133F, GLU104F, GLU126F, GLU126K, GLU130F, GLU131F, GLU132F, GLU140F, GLU69K, GLU99F, GLY117K, ILE103F, ILE119K, ILE128F, ILE129F, LEU110F, LEU110K, LEU124K, LEU136F, LEU70K, LYS111F, LYS114F, LYS114K, LYS9K, PHE125F, SER107F, THR121K, THR137F, TYR106F, VAL120K
• F-L: ALA155F, ALA155L, ALA158L, ASN141F, ASN148F, ASP151F, ASP151L, ASP38L, ASP39L, ASP41L, GLU140F, GLU44F, GLU44L, GLY150F, GLY150L, GLY159L, GLY43L, HIS145F, ILE142F, ILE146F, ILE157F, ILE157L, LEU149F, LEU154F, LEU154L, LEU37L, LYS147F, LYS156F, LYS156L, MET40L, PRO161L, SER144F, THR137F, THR152F, THR152L, THR160L, TYR138F, TYR153F, TYR153L, TYR42L
• F-P: ALA101P, ALA105P, ALA122F, ALA122P, ALA134P, ALA2F, ARG123F, ARG123P, ARG127F, ARG127P, ARG5F, ARG66F, ARG8F, ASN141P, ASP100P, ASP118F, ASP97P, GLN108P, GLN116F, GLN133P, GLU104P, GLU115F, GLU126F, GLU126P, GLU130P, GLU131P, GLU132P, GLU140P, GLU69F, GLU99P, GLY117F, ILE103P, ILE119F, ILE128P, ILE129P, LEU110F, LEU110P, LEU124F, LEU136P, LEU70F, LYS111P, LYS114F, LYS114P, LYS9F, PHE125P, SER107P, THR121F, THR137P, TYR106P, VAL120F
• G-H: ALA134G, ALA134H, ALA167G, ALA167H, ALA21H, ALA47G, ALA47H, ALA53G, ALA53H, ALA60G, ALA60H, ALA64G, ALA64H, ARG127G, ARG127H, ARG20G, ARG20H, ARG58G, ARG58H, ASN141G, ASN141H, ASN32G, ASN32H, ASN48G, ASN48H, ASN62G, ASN62H, ASP38G, ASP38H, ASP39G, ASP39H, ASP55G, ASP55H, GLN133G, GLN133H, GLN29G, GLN29H, GLN33G, GLN33H, GLN77G, GLN77H, GLN86G, GLN86H, GLU130G, GLU130H, GLU131G, GLU131H, GLU132G, GLU132H, GLU23H, GLU44G, GLU44H, GLU56G, GLU56H, GLU61G, GLU61H, GLU65G, GLU65H, GLU69G, GLU69H, GLU73G, GLU73H, GLY165G, GLY165H, GLY170G, GLY170H, GLY71G, GLY71H, GLY72G, GLY72H, GLY85G, GLY85H, HIS135G, HIS135H, HIS25G, HIS25H, HIS28G, HIS28H, HIS34G, HIS34H, HIS59G, HIS59H, ILE128G, ILE128H, ILE142G, ILE142H, ILE27G, ILE27H, ILE52G, ILE52H, ILE54G, ILE54H, ILE67G, ILE67H, ILE91G, LEU136G, LEU136H, LEU24G, LEU24H, LEU37G, LEU37H, LEU51G, LEU51H, LEU70G, LEU70H, LYS169G, LYS169H, LYS50G, LYS50H, LYS68G, LYS68H, LYS78G, LYS78H, LYS81G, LYS81H, MET31G, MET31H, MET40G, MET40H, MET49G, MET49H, MET57G, MET57H, PHE171G, PHE171H, PHE63G, PHE63H, PRO74G, PRO74H, SER162G, SER162H, SER163G, SER168G, SER168H, SER36G, SER36H, THR137G, THR137H, THR164G, THR164H, THR166G, THR166H, THR75G, THR75H, THR76G, THR76H, THR84G, THR84H, TYR138G, TYR138H, TYR139G, TYR139H, TYR35G, TYR35H, VAL172G, VAL172H, VAL82G, VAL82H, VAL83G, VAL83H
• G-I: ALA155G, ALA155I, ALA158G, ASN141I, ASN148I, ASP151G, ASP151I, ASP38G, ASP39G, ASP41G, GLU140I, GLU44G, GLU44I, GLY150G, GLY150I, GLY159G, GLY43G, HIS145I, ILE142I, ILE146I, ILE157G, ILE157I, LEU149G, LEU149I, LEU154G, LEU154I, LEU37G, LYS147I, LYS156G, LYS156I, MET40G, PRO161G, SER144I, THR137I, THR152G, THR152I, THR160G, TYR138I, TYR153G, TYR153I, TYR42G
• G-M: ALA155G, ALA155M, ALA158M, ASN141G, ASN148G, ASP151G, ASP151M, ASP38M, ASP39M, ASP41M, GLU140G, GLU44G, GLY150G, GLY150M, GLY159M, GLY43M, HIS145G, ILE142G, ILE146G, ILE157G, ILE157M, LEU149G, LEU149M, LEU154G, LEU154M, LEU37M, LYS156G, LYS156M, MET40M, SER144G, THR137G, THR152G, THR152M, THR160M, TYR138G, TYR153G, TYR153M, TYR42M
• G-N: ALA101G, ALA105G, ALA122G, ALA122N, ALA134G, ARG123G, ARG123N, ARG127G, ARG127N, ARG5N, ARG66N, ARG8N, ASP100G, ASP118N, ASP97G, GLN108G, GLN116N, GLN133G, GLU104G, GLU115N, GLU126G, GLU126N, GLU130G, GLU131G, GLU132G, GLU140G, GLU69N, GLY117N, ILE103G, ILE119N, ILE128G, ILE129G, LEU110G, LEU110N, LEU124N, LEU136G, LEU70N, LYS111G, LYS114G, LYS114N, LYS9N, PHE125G, SER107G, THR121N, THR137G, TYR106G, VAL120N
• H-I: ALA101I, ALA105I, ALA122H, ALA122I, ALA134I, ARG123H, ARG123I, ARG127H, ARG127I, ARG5H, ARG66H, ARG8H, ASP100I, ASP118H, ASP97I, GLN108I, GLN116H, GLN133I, GLU104I, GLU126H, GLU126I, GLU130I, GLU131I, GLU132I, GLU140I, GLU69H, GLY117H, ILE103I, ILE119H, ILE128I, ILE129I, LEU110H, LEU110I, LEU124H, LEU136I, LEU70H, LYS111I, LYS114H, LYS114I, LYS9H, PHE125I, SER107I, THR121H, THR137I, TYR106I, VAL120H
• H-P: ASN148P, ASP151H, LYS147P, THR152H
• I-J: ALA134I, ALA134J, ALA167I, ALA167J, ALA47I, ALA47J, ALA53I, ALA53J, ALA60I, ALA60J, ALA64I, ALA64J, ARG127I, ARG127J, ARG20I, ARG20J, ARG58I, ARG58J, ASN141I, ASN141J, ASN32I, ASN32J, ASN48I, ASN48J, ASN62I, ASN62J, ASP38I, ASP38J, ASP39I, ASP39J, ASP55I, ASP55J, GLN133I, GLN133J, GLN29I, GLN29J, GLN33I, GLN33J, GLN77I, GLN77J, GLN86I, GLN86J, GLU130I, GLU130J, GLU131I, GLU131J, GLU132I, GLU132J, GLU44I, GLU44J, GLU56I, GLU56J, GLU61I, GLU61J, GLU65I, GLU65J, GLU69I, GLU69J, GLU73I, GLU73J, GLY165I, GLY165J, GLY170I, GLY170J, GLY71I, GLY71J, GLY72I, GLY72J, GLY85I, GLY85J, HIS135I, HIS135J, HIS25I, HIS25J, HIS28I, HIS28J, HIS34I, HIS34J, HIS59I, HIS59J, ILE128I, ILE128J, ILE142I, ILE142J, ILE27I, ILE27J, ILE52I, ILE52J, ILE54I, ILE54J, ILE67I, ILE67J, ILE91J, LEU136I, LEU136J, LEU24I, LEU24J, LEU37I, LEU37J, LEU51I, LEU51J, LEU70I, LEU70J, LYS169I, LYS169J, LYS50I, LYS50J, LYS68I, LYS68J, LYS78I, LYS78J, LYS81I, LYS81J, MET31I, MET31J, MET40I, MET40J, MET49I, MET49J, MET57I, MET57J, PHE171I, PHE171J, PHE63I, PHE63J, PRO74I, PRO74J, SER162J, SER163I, SER168I, SER168J, SER36I, SER36J, THR137I, THR137J, THR164I, THR164J, THR166I, THR166J, THR75I, THR75J, THR76I, THR76J, THR84I, THR84J, TYR138I, TYR138J, TYR139I, TYR139J, TYR35I, TYR35J, VAL172I, VAL172J, VAL82I, VAL82J, VAL83I, VAL83J
• I-M: ALA155I, ALA155M, THR152I, THR152M
• K-L: ALA134K, ALA134L, ALA167K, ALA167L, ALA21L, ALA47K, ALA47L, ALA53K, ALA53L, ALA60K, ALA60L, ALA64K, ALA64L, ARG127K, ARG127L, ARG20K, ARG20L, ARG58K, ARG58L, ASN141K, ASN141L, ASN32K, ASN32L, ASN48K, ASN48L, ASN62K, ASN62L, ASP38K, ASP38L, ASP39K, ASP39L, ASP55K, ASP55L, GLN133K, GLN133L, GLN29K, GLN29L, GLN33K, GLN33L, GLN77K, GLN77L, GLN86K, GLN86L, GLU130K, GLU130L, GLU131K, GLU131L, GLU132K, GLU132L, GLU44K, GLU44L, GLU56K, GLU56L, GLU61K, GLU61L, GLU65K, GLU65L, GLU69K, GLU69L, GLU73K, GLU73L, GLY165K, GLY165L, GLY170K, GLY170L, GLY71K, GLY71L, GLY72K, GLY72L, GLY85K, GLY85L, HIS135K, HIS135L, HIS25K, HIS25L, HIS28K, HIS28L, HIS34K, HIS34L, HIS59K, HIS59L, ILE128K, ILE128L, ILE142K, ILE142L, ILE27K, ILE27L, ILE52K, ILE52L, ILE54K, ILE54L, ILE67K, ILE67L, ILE91K, LEU136K, LEU136L, LEU24K, LEU24L, LEU37K, LEU37L, LEU51K, LEU51L, LEU70K, LEU70L, LYS169K, LYS169L, LYS50K, LYS50L, LYS68K, LYS68L, LYS78K, LYS78L, LYS81K, LYS81L, MET31K, MET31L, MET40K, MET40L, MET49K, MET49L, MET57K, MET57L, PHE171K, PHE171L, PHE63K, PHE63L, PRO74K, PRO74L, SER162K, SER168K, SER168L, SER36K, SER36L, THR137K, THR137L, THR164K, THR164L, THR166K, THR166L, THR75K, THR75L, THR76K, THR76L, THR84K, THR84L, TYR138K, TYR138L, TYR139K, TYR139L, TYR35K, TYR35L, VAL172K, VAL172L, VAL82K, VAL82L, VAL83K, VAL83L
• K-O: ALA155K, ALA155O, ALA158O, ASN141K, ASN148K, ASP151K, ASP151O, ASP38O, ASP39O, ASP41O, GLU140K, GLU44K, GLY150K, GLY150O, GLY159O, GLY43O, HIS145K, ILE142K, ILE146K, ILE157K, ILE157O, LEU149K, LEU149O, LEU154K, LEU154O, LEU37O, LYS156K, LYS156O, MET40O, PRO161O, SER144K, SER162O, THR137K, THR152K, THR152O, THR160O, TYR138K, TYR153K, TYR153O, TYR42O
• K-P: ALA101K, ALA105K, ALA122K, ALA122P, ALA134K, ARG123K, ARG123P, ARG127K, ARG127P, ARG5P, ARG66P, ARG8P, ASN141K, ASP100K, ASP118P, ASP97K, GLN108K, GLN116P, GLN133K, GLU104K, GLU115P, GLU126K, GLU126P, GLU130K, GLU131K, GLU132K, GLU140K, GLU69P, GLY117P, ILE103K, ILE119P, ILE128K, ILE129K, LEU110K, LEU110P, LEU124P, LEU136K, LEU70P, LYS111K, LYS114K, LYS114P, LYS9P, PHE125K, SER107K, THR121P, THR137K, TYR106K, VAL120P
• M-N: ALA134M, ALA134N, ALA167M, ALA167N, ALA21M, ALA21N, ALA47M, ALA47N, ALA53M, ALA53N, ALA60M, ALA60N, ALA64M, ALA64N, ARG127M, ARG127N, ARG20M, ARG20N, ARG58M, ARG58N, ASN141M, ASN141N, ASN32M, ASN32N, ASN48M, ASN48N, ASN62M, ASN62N, ASP38M, ASP38N, ASP39M, ASP39N, ASP55M, ASP55N, GLN133M, GLN133N, GLN29M, GLN29N, GLN33M, GLN33N, GLN77M, GLN77N, GLN86M, GLN86N, GLU130M, GLU130N, GLU131M, GLU131N, GLU132M, GLU132N, GLU44M, GLU44N, GLU56M, GLU56N, GLU61M, GLU61N, GLU65M, GLU65N, GLU69M, GLU69N, GLU73M, GLU73N, GLY165M, GLY165N, GLY170M, GLY170N, GLY71M, GLY71N, GLY72M, GLY72N, GLY85M, GLY85N, HIS135M, HIS135N, HIS25M, HIS25N, HIS28M, HIS28N, HIS34M, HIS34N, HIS59M, HIS59N, ILE128M, ILE128N, ILE142M, ILE142N, ILE27M, ILE27N, ILE52M, ILE52N, ILE54M, ILE54N, ILE67M, ILE67N, ILE91M, LEU136M, LEU136N, LEU24M, LEU24N, LEU37M, LEU37N, LEU45N, LEU51M, LEU51N, LEU70M, LEU70N, LYS169M, LYS169N, LYS50M, LYS50N, LYS68M, LYS68N, LYS78M, LYS78N, LYS81M, LYS81N, MET31M, MET31N, MET40M, MET40N, MET49M, MET49N, MET57M, MET57N, PHE171M, PHE171N, PHE63M, PHE63N, PRO74M, PRO74N, SER162M, SER168M, SER168N, SER36M, SER36N, THR137M, THR137N, THR164M, THR164N, THR166M, THR166N, THR75M, THR75N, THR76M, THR76N, THR84M, THR84N, TYR138M, TYR138N, TYR139M, TYR139N, TYR35M, TYR35N, VAL172M, VAL172N, VAL82M, VAL82N, VAL83M, VAL83N
• O-P: ALA134O, ALA134P, ALA167O, ALA167P, ALA47O, ALA47P, ALA53O, ALA53P, ALA60O, ALA60P, ALA64O, ALA64P, ARG127O, ARG127P, ARG20O, ARG20P, ARG58O, ARG58P, ARG66P, ASN141O, ASN141P, ASN32O, ASN32P, ASN48O, ASN48P, ASN62O, ASN62P, ASP38O, ASP38P, ASP39O, ASP39P, ASP55O, ASP55P, GLN133O, GLN133P, GLN29O, GLN29P, GLN33O, GLN33P, GLN77O, GLN77P, GLN86O, GLN86P, GLU130O, GLU130P, GLU131O, GLU131P, GLU132O, GLU132P, GLU44O, GLU44P, GLU56O, GLU56P, GLU61O, GLU61P, GLU65O, GLU65P, GLU69O, GLU69P, GLU73O, GLU73P, GLY165O, GLY165P, GLY170O, GLY170P, GLY71O, GLY71P, GLY72O, GLY72P, GLY80O, GLY85O, GLY85P, HIS135O, HIS135P, HIS25O, HIS25P, HIS28O, HIS28P, HIS34O, HIS34P, HIS59O, HIS59P, ILE128O, ILE128P, ILE142O, ILE142P, ILE27O, ILE27P, ILE52O, ILE52P, ILE54O, ILE54P, ILE67O, ILE67P, ILE91O, LEU136O, LEU136P, LEU24O, LEU24P, LEU37O, LEU37P, LEU51O, LEU51P, LEU70O, LEU70P, LYS169O, LYS169P, LYS50O, LYS50P, LYS68O, LYS68P, LYS78O, LYS78P, LYS81O, LYS81P, MET31O, MET31P, MET40O, MET40P, MET49O, MET49P, MET57O, MET57P, PHE171O, PHE171P, PHE63O, PHE63P, PRO74O, PRO74P, SER168O, SER168P, SER36O, SER36P, THR137O, THR137P, THR164O, THR164P, THR166O, THR166P, THR173O, THR75O, THR75P, THR76O, THR76P, THR84O, THR84P, TYR138O, TYR138P, TYR139O, TYR139P, TYR35O, TYR35P, VAL172O, VAL172P, VAL82O, VAL82P, VAL83O, VAL83P