1N8R

structure of large ribosomal subunit in complex with virginiamycin m

• Total interactions analyzed: 435
• Total true interactions: 27
• Strongest Interaction:
  • Chains: E-2
  • Int. Res.: 16
  • Norm. En. per Res.: -3.8467
• Hub Node: E(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
C-N	0.0	0.0	-0.0435	-0.0435	3	0	0	19	0	0	2
C-1	-86.8004	-23.5843	-296.593	-406.9777	112	20	12	12371	2	21	24
D-K	-18.5107	-26.4442	-46.0659	-91.0208	34	2	0	1945	1	3	0
D-L	0.0	9.3131	-51.0598	-41.7467	39	1	0	2575	0	11	19
D-V	-17.1237	8.5783	-39.8137	-48.3591	24	6	0	1348	0	5	5
E-M	0.0	0.0	-0.0024	-0.0024	2	0	0	3	0	0	3
E-P	0.0	4.4287	-44.9389	-40.5102	20	4	0	1689	0	8	6
E-U	0.0	0.8608	-13.5964	-12.7356	14	0	0	819	0	3	10
E-Z	0.0	0.0	-0.0116	-0.0116	2	0	0	9	0	0	1
E-2	-4.6161	-14.5838	-42.3466	-61.5464	16	3	0	1416	2	6	6
F-O	-15.2821	-0.6686	-47.8499	-63.8006	27	8	1	2234	0	13	20
G-K	-10.4947	7.5552	-63.8838	-66.8233	26	5	1	2419	0	7	7
H-N	-38.6574	-11.7672	-172.996	-223.4206	74	14	3	7869	4	28	27
J-R	0.0	0.0	-0.031	-0.031	3	0	0	12	0	0	0
L-V	-48.6792	-13.6683	-145.452	-207.7994	55	10	3	5930	1	18	20
M-N	0.0	0.0	-0.0118	-0.0118	2	0	0	10	0	0	1
M-P	0.0	0.0	-12.8217	-12.8217	25	0	0	919	0	5	5
M-Z	0.0	0.0	-11.7413	-11.7413	13	1	0	389	0	0	12
M-4	0.0	0.0	-4.4039	-4.4039	5	0	0	198	0	0	2
N-4	0.0	-1.1768	-24.0803	-25.2571	20	15	0	1903	0	4	1
O-R	-10.2375	2.1275	-95.5492	-103.6592	55	5	3	4833	0	11	17
S-Y	0.0	0.0	-0.0978	-0.0978	3	0	0	8	0	0	8
S-3	0.0	0.0	-0.1039	-0.1039	4	0	0	33	0	0	1
T-W	0.0	-3.1061	-55.9728	-59.0789	37	4	5	3003	1	11	13
T-3	-15.5115	-2.1067	-48.6295	-66.2477	24	2	0	2247	0	19	11
U-3	0.0	0.0	-0.043	-0.043	2	0	0	8	0	2	2
2-3	0.0	-1.7906	-45.2861	-47.0767	23	6	0	1691	0	19	16

Interface residues

• C-N: ARG3C, ARG76N, ASN78N
• C-1: ALA172C, ALA271, ALA501, ALA53C, ALA56C, ALA57C, ALA651, ALA70C, ALA751, ALA781, ALA821, ALA89C, ARG131, ARG164C, ARG171, ARG182C, ARG231, ARG251, ARG491, ARG51C, ASN125C, ASN174C, ASP166C, ASP281, ASP44C, ASP48C, ASP78C, CYS601, CYS681, GLN127C, GLN701, GLU101C, GLU301, GLU46C, GLU721, GLU72C, GLY102C, GLY123C, GLY157C, GLY160C, GLY161C, GLY162C, GLY163C, GLY173C, GLY191, GLY511, GLY531, GLY611, GLY661, GLY671, GLY73C, GLY75C, GLY761, GLY77C, GLY91C, HIS331, HIS47C, ILE156C, ILE221, ILE311, ILE45C, ILE541, ILE641, ILE88C, LEU201, LYS167C, LYS171C, LYS211, LYS24C, LYS341, LYS631, LYS771, LYS811, MET561, MET801, PHE141, PHE169C, PRO100C, PRO104C, PRO168C, PRO401, PRO54C, PRO711, PRO71C, PRO90C, SER122C, SER52C, THR111, THR165C, THR521, THR731, TRP551, TYR181, TYR621, TYR691, VAL103C, VAL105C, VAL124C, VAL158C, VAL159C, VAL170C, VAL241, VAL261, VAL291, VAL411, VAL42C, VAL43C, VAL55C, VAL741, VAL74C, VAL76C, VAL791
• D-K: ALA4K, ARG102K, ARG246D, ARG248D, ARG74K, ARG95D, ASN107K, ASN142K, ASN65K, ASN67K, ASP66K, ASP76K, ASP89D, GLN94D, GLU42K, GLY106K, GLY64K, GLY68K, GLY93D, LEU105K, LYS143K, PRO108K, PRO244D, PRO91D, SER249D, THR144K, THR250D, THR90D, TRP145K, TYR104K, TYR92D, VAL103K, VAL247D, VAL251D
• D-L: ALA3L, ALA6L, ARG115L, ARG43L, ARG5D, ARG62D, ARG81L, ARG82L, ARG87L, ASN42L, ASN55D, ASP84L, GLN119L, GLN221D, GLN2D, GLU2L, GLU66D, GLU67D, GLY39L, GLY5L, GLY85L, HIS50D, LEU4L, LEU53D, LYS224D, LYS41L, LYS8D, MET65D, PRO3D, PRO61D, PRO6D, PRO70D, PRO83L, SER4D, THR40L, THR68D, THR86L, VAL52D, VAL69D
• D-V: ASN332D, ASP12V, ASP281D, CYS32V, GLU14V, GLU333D, GLU66D, GLU67D, GLY16V, GLY337D, HIS50D, ILE13V, PRO15V, SER331D, SER334D, SER33V, THR17V, THR68D, TYR329D, VAL280D, VAL330D, VAL51D, VAL52D, VAL69D
• E-M: ARG8M, HIS90E
• E-P: ARG27E, ARG36E, ARG37P, ARG6P, ASN4P, ASP29E, GLU23E, LEU109E, LEU30E, LEU7P, LYS2P, LYS33E, PRO25E, PRO5P, SER113E, SER28E, SER8P, THR24E, THR3P, VAL26E
• E-U: ALA181E, ARG182E, ARG184E, ARG8U, ASP5U, GLN3U, GLN44E, GLY179E, GLY183E, LYS185E, LYS2U, PRO4U, SER180E, TYR186E
• E-Z: ALA176E, LYS208Z
• E-2: ALA52E, ALA542, ALA58E, ARG55E, ARG79E, ASP49E, GLU50E, GLU562, GLY53E, GLY552, LEU54E, LYS532, PRO57E, SER522, THR56E, TYR51E
• F-O: ALA147F, ALA16O, ALA36O, ARG11O, ARG12O, ARG13O, ARG140F, ARG144F, ARG149F, ARG14O, ARG17O, ARG37O, ASN107O, ASN40O, ASP145F, GLU15O, GLY105O, ILE104O, LEU106O, LYS114O, LYS146F, LYS38O, SER108O, SER148F, SER39O, THR18O, VAL115O
• G-K: ARG123K, ARG32G, ASN126K, ASP122K, ASP37G, ASP39G, GLU53G, HIS17G, ILE127K, ILE38G, LEU121K, LEU124K, LEU18G, LEU33G, LYS128K, LYS57G, PHE129K, PHE65G, PRO36G, SER125K, THR61G, TRP34G, TYR35G, VAL130K, VAL40G, VAL45K
• H-N: ALA11N, ALA1N, ALA21N, ALA4N, ALA95H, ARG27N, ARG2N, ARG42H, ARG42N, ARG45N, ARG50N, ARG64N, ARG9N, ASN34H, ASP47N, ASP5H, GLN19N, GLN55H, GLN80H, GLU10N, GLU130N, GLU17N, GLU22N, GLU30N, GLU35H, GLU41H, GLU41N, GLU57H, GLU58H, GLU65H, GLU69H, GLY18N, GLY32H, HIS26N, HIS62H, ILE20N, ILE40H, ILE40N, ILE59H, ILE63H, ILE8N, LEU23N, LEU46N, LEU66H, LYS38H, LYS70H, MET24N, MET61H, PHE76H, PRO15N, PRO1H, PRO43N, PRO56H, PRO64H, SER39H, SER3N, SER6N, THR33H, THR36H, THR37H, THR44N, TRP12N, TRP31N, TYR118N, TYR3H, TYR54N, TYR5N, TYR7N, VAL120N, VAL2H, VAL4H, VAL54H, VAL60H, VAL91H
• J-R: ARG11R, ARG16J, TYR19J
• L-V: ALA114L, ALA27V, ARG115L, ARG4V, ARG75L, ARG77L, ARG81L, ARG82L, ARG87L, ASN38V, ASP25V, ASP41V, ASP84L, ASP92L, CYS32V, GLN76L, GLU14V, GLU37V, GLU91L, GLY111L, GLY16V, GLY18V, GLY26V, GLY85L, HIS23V, HIS30V, ILE113L, ILE131L, ILE13V, ILE80L, LEU49L, LYS110L, LYS24V, LYS89L, MET130L, MET20V, PHE21V, PHE31V, PHE90L, PRO112L, PRO15V, PRO79L, PRO83L, SER33V, SER34V, THR129L, THR17V, THR19L, THR19V, THR28V, THR29V, THR86L, VAL132L, VAL22V, VAL88L
• M-N: LYS178N, LYS56M
• M-P: ARG115M, ARG50P, ARG67M, ASN72M, ASP70M, GLN113M, GLN71P, GLN91P, GLU49P, GLU68M, GLU71M, GLY46P, GLY66P, GLY68P, HIS116M, LEU45P, LEU70P, LEU75M, LYS88P, SER67P, THR74M, THR84P, THR87P, VAL69P, VAL73M
• M-Z: ARG11M, ARG144Z, ARG147Z, ARG6M, ARG8M, GLN149Z, GLN7M, GLY148Z, GLY9M, HIS13M, LYS145Z, SER10M, THR12M
• M-4: GLN394, ILE364, LYS48M, LYS514, TRP354
• N-4: ARG74N, ARG82N, ARG85N, ARG90N, ASN434, ASN484, ASN89N, ASP494, GLY454, GLY474, GLY504, ILE464, ILE91N, LYS84N, MET86N, MET87N, SER444, SER83N, THR92N, VAL88N
• O-R: ALA29R, ALA88R, ALA89R, ARG13O, ARG19R, ARG21R, ARG23O, ARG25O, ARG28R, ARG5O, ARG93R, ASN16R, ASN49R, ASN53O, ASP19O, ASP20R, ASP55O, ASP69R, GLN22O, GLN27R, GLU31R, GLU32R, GLY22R, GLY30O, GLY3O, GLY51O, GLY54O, HIS21O, LEU24O, LEU26O, LEU27O, LEU50O, LYS15R, LYS17R, LYS28O, LYS7O, MET10O, PRO18R, PRO25R, PRO26R, PRO48R, PRO4O, PRO52O, PRO9O, SER24R, SER29O, SER46R, THR18O, THR23R, THR87R, TYR20O, TYR6O, VAL30R, VAL47R, VAL8O
• S-Y: ASP44Y, ASP46Y, GLU52S
• S-3: ARG125S, ARG443, LYS126S, PRO127S
• T-W: ALA27T, ALA30W, ALA32W, ALA35W, ALA36W, ALA40T, ALA78T, ARG31W, ARG80T, ASN29W, ASP21W, ASP3T, GLN34W, GLN44T, GLY37W, GLY38W, HIS7T, HIS9T, ILE53W, ILE5T, ILE81T, LEU27W, LEU28W, LYS24W, LYS57W, LYS6T, PHE26T, PRO8T, SER1T, THR11T, THR25W, TRP2T, TYR45T, VAL10T, VAL33W, VAL41T, VAL4T
• T-3: ALA123, ALA32T, ARG103, ARG31T, ASN163, ASN56T, ASP153, ASP29T, ASP30T, ASP59T, GLN55T, GLU61T, GLY60T, LEU113, LEU143, LYS133, LYS33, LYS53, LYS62T, LYS83, LYS93, MET58T, THR57T, THR73
• U-3: ASP303, LYS69U
• 2-3: ALA63, ARG103, ARG202, ASP463, ASP483, CYS192, GLU242, GLU493, GLY13, GLY232, HIS162, LEU143, LYS133, LYS182, LYS252, SER262, THR142, THR152, THR172, THR292, THR473, THR73, TYR272