1N6E

tricorn protease in complex with a tridecapeptide chloromethyl ketone derivative

• Total interactions analyzed: 66
• Total true interactions: 24
• Strongest Interaction:
  • Chains: E-G
  • Int. Res.: 489
  • Norm. En. per Res.: -5.2541
• Hub Node: A(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-38.3738	-10.2185	-159.34	-207.9323	94	27	6	7983	1	10	11
A-C	-420.8265	-319.2708	-1800.51	-2540.6073	490	113	23	68172	22	172	189
A-D	0.0	0.0	-7.1794	-7.1794	20	0	0	532	0	3	2
A-E	0.0	8.9723	-80.3567	-71.3845	42	2	1	3445	1	23	9
A-G	-57.6514	-63.0446	-381.812	-502.5079	214	12	0	17185	16	114	105
A-I	0.0	10.3358	-89.2325	-78.8967	45	9	1	3718	1	23	9
B-C	0.0	0.0	-7.1285	-7.1285	20	0	0	532	0	3	2
C-D	-38.7779	-10.2797	-156.614	-205.6716	94	28	6	7989	1	10	11
C-G	0.0	10.098	-75.4346	-65.3366	45	5	1	3678	1	23	9
C-I	-73.7819	-60.5019	-399.675	-533.9588	216	14	0	17594	16	117	105
C-K	0.0	8.7123	-80.701	-71.9887	42	2	1	3442	1	23	8
E-F	-41.2264	-10.4724	-196.59	-248.2888	95	25	6	7997	1	10	11
E-G	-456.5362	-324.8752	-1787.85	-2569.2614	489	126	23	68590	24	166	184
E-H	0.0	0.0	-6.8551	-6.8551	20	0	0	521	0	3	2
E-I	0.0	8.1673	-76.6991	-68.5318	43	6	1	3432	1	23	11
E-K	-105.0009	-58.3728	-393.713	-557.0867	214	15	0	17573	14	117	108
F-G	0.0	0.0	-7.0586	-7.0586	21	0	0	526	0	3	2
G-H	-40.0487	-10.3543	-191.186	-241.589	95	22	6	7970	1	10	11
G-K	0.0	8.1099	-73.0231	-64.9132	42	6	1	3379	1	23	11
I-J	-38.589	-10.4896	-187.007	-236.0856	94	22	6	7978	1	10	11
I-K	-469.4342	-330.5131	-1756.96	-2556.9074	487	116	23	68371	24	164	186
I-L	0.0	0.0	-6.942	-6.942	21	0	0	524	0	3	2
J-K	0.0	0.0	-6.9424	-6.9424	20	0	0	527	0	3	2
K-L	-40.7269	-10.3226	-197.166	-248.2155	95	26	6	7982	1	10	11

Interface residues

• A-B: ALA1012A, ALA1206B, ALA1207B, ALA1208B, ALA447A, ALA502A, ALA504A, ARG586A, ARG640A, ARG651A, ASP328A, ASP451A, ASP500A, ASP584A, ASP638A, ASP886A, ASP966A, ASP968A, GLN1008A, GLN1204B, GLN478A, GLN922A, GLU1010A, GLU1209B, GLU605A, GLU615A, GLY464A, GLY617A, GLY888A, GLY916A, GLY917A, GLY918A, GLY964A, GLY967A, GLY990A, GLY993A, HIS499A, HIS603A, HIS746A, ILE480A, ILE588A, ILE589A, ILE969A, ILE994A, LEU1210B, LEU515A, LEU636A, LEU639A, LEU923A, LYS1205B, LYS616A, LYS997A, MET448A, MET587A, MET887A, MET889A, PHE1011A, PHE1013A, PHE1212B, PHE1213B, PHE329A, PHE408A, PHE452A, PHE919A, PHE970A, PRO1009A, PRO503A, PRO614A, PRO996A, SER537A, SER599A, SER745A, SER921A, SER965A, THR1007A, THR1203B, THR1211B, THR450A, THR453A, THR637A, THR995A, TRP1014A, TRP988A, TYR501A, TYR514A, TYR517A, TYR585A, TYR598A, TYR609A, TYR748A, VAL600A, VAL920A, VAL991A, VAL992A
• A-C: ALA1012A, ALA1012C, ALA1018A, ALA1018C, ALA447A, ALA447C, ALA479A, ALA479C, ALA493A, ALA493C, ALA607A, ALA607C, ALA608A, ALA608C, ALA697A, ALA697C, ALA705A, ALA705C, ALA707A, ALA707C, ALA783A, ALA783C, ARG1016A, ARG1016C, ARG425A, ARG425C, ARG443A, ARG443C, ARG445A, ARG445C, ARG518A, ARG518C, ARG526A, ARG526C, ARG557A, ARG557C, ARG574A, ARG574C, ARG586A, ARG586C, ARG698A, ARG698C, ARG834A, ARG834C, ARG836A, ARG836C, ARG845A, ARG845C, ARG861A, ARG861C, ARG868A, ARG868C, ARG897A, ARG897C, ARG932A, ARG932C, ARG939A, ARG939C, ARG940A, ARG940C, ARG952A, ARG952C, ASN406A, ASN406C, ASN423A, ASN423C, ASN497A, ASN497C, ASN530A, ASN530C, ASN550A, ASN550C, ASN569A, ASN569C, ASN579A, ASN579C, ASN700A, ASN700C, ASN703A, ASN703C, ASN788A, ASN788C, ASN893A, ASN893C, ASN901A, ASN901C, ASN930A, ASN930C, ASN937A, ASN937C, ASN949A, ASN949C, ASP1017A, ASP1017C, ASP424A, ASP424C, ASP473A, ASP473C, ASP500A, ASP500C, ASP521A, ASP521C, ASP525A, ASP525C, ASP567A, ASP567C, ASP570A, ASP570C, ASP581A, ASP581C, ASP584A, ASP584C, ASP699A, ASP699C, ASP785A, ASP785C, ASP801A, ASP801C, ASP846A, ASP846C, ASP850A, ASP850C, ASP936A, ASP936C, ASP966A, ASP966C, ASP968A, ASP968C, GLN1008A, GLN1008C, GLN922A, GLN922C, GLU1010A, GLU1010C, GLU446A, GLU446C, GLU471A, GLU471C, GLU496A, GLU496C, GLU534A, GLU534C, GLU562A, GLU562C, GLU605A, GLU605C, GLU615A, GLU615C, GLU704A, GLU704C, GLU789A, GLU789C, GLU791A, GLU791C, GLU797A, GLU797C, GLU865A, GLU865C, GLU894A, GLU894C, GLU902A, GLU902C, GLU926A, GLU926C, GLY1019A, GLY1019C, GLY470A, GLY470C, GLY474A, GLY474C, GLY547A, GLY547C, GLY583A, GLY583C, GLY604A, GLY604C, GLY784A, GLY784C, GLY790A, GLY790C, GLY799A, GLY799C, GLY888A, GLY888C, GLY891A, GLY891C, GLY934A, GLY934C, GLY941A, GLY941C, GLY953A, GLY953C, GLY978A, GLY978C, GLY993A, GLY993C, HIS469A, HIS469C, HIS499A, HIS499C, HIS603A, HIS603C, HIS872A, HIS872C, ILE480A, ILE480C, ILE542A, ILE542C, ILE545A, ILE545C, ILE578A, ILE578C, ILE795A, ILE795C, ILE800A, ILE800C, ILE849A, ILE849C, ILE900A, ILE900C, ILE924A, ILE924C, ILE925A, ILE925C, ILE933A, ILE933C, ILE969A, ILE969C, LEU467A, LEU467C, LEU520A, LEU520C, LEU529A, LEU529C, LEU696A, LEU696C, LEU847A, LEU847C, LEU852A, LEU852C, LEU892A, LEU892C, LEU898A, LEU898C, LEU923A, LEU923C, LEU928A, LEU928C, LEU943A, LEU943C, LEU977A, LEU977C, LEU979A, LEU979C, LYS468A, LYS468C, LYS538A, LYS538C, LYS553A, LYS553C, LYS573A, LYS573C, LYS616A, LYS616C, LYS695A, LYS695C, LYS708A, LYS708C, LYS792A, LYS792C, LYS927A, LYS927C, LYS931A, LYS931C, LYS975A, LYS975C, LYS976A, LYS976C, LYS997A, LYS997C, MET448A, MET448C, MET477A, MET477C, MET559A, MET559C, MET571A, MET571C, MET848A, MET848C, MET887A, MET887C, MET889A, MET889C, MET890A, MET890C, MET929A, MET929C, PHE1011A, PHE1011C, PHE1013A, PHE1013C, PHE1015A, PHE1015C, PHE1020A, PHE1020C, PHE408A, PHE408C, PHE426A, PHE426C, PHE531A, PHE531C, PHE533A, PHE533C, PHE540A, PHE540C, PHE606A, PHE606C, PHE796A, PHE796C, PHE857A, PHE857C, PHE895A, PHE895C, PHE899A, PHE899C, PHE919A, PHE919C, PHE970A, PHE970C, PHE972A, PHE972C, PHE974A, PHE974C, PRO1009A, PRO1009C, PRO522A, PRO522C, PRO524A, PRO524C, PRO539A, PRO539C, PRO543A, PRO543C, PRO546A, PRO546C, PRO549A, PRO549C, PRO556A, PRO556C, PRO577A, PRO577C, PRO582A, PRO582C, PRO601A, PRO601C, PRO794A, PRO794C, PRO802A, PRO802C, PRO938A, PRO938C, PRO945A, PRO945C, PRO947A, PRO947C, SER444A, SER444C, SER498A, SER498C, SER516A, SER516C, SER519A, SER519C, SER523A, SER523C, SER532A, SER532C, SER537A, SER537C, SER548A, SER548C, SER558A, SER558C, SER561A, SER561C, SER575A, SER575C, SER576A, SER576C, SER711A, SER711C, SER787A, SER787C, SER793A, SER793C, SER832A, SER832C, SER903A, SER903C, SER904A, SER904C, SER921A, SER921C, SER944A, SER944C, SER950A, SER950C, SER971A, SER971C, SER973A, SER973C, THR472A, THR472C, THR494A, THR494C, THR495A, THR495C, THR560A, THR560C, THR942A, THR942C, THR948A, THR948C, TRP1014A, TRP1014C, TRP702A, TRP702C, TYR475A, TYR475C, TYR501A, TYR501C, TYR514A, TYR514C, TYR517A, TYR517C, TYR572A, TYR572C, TYR585A, TYR585C, TYR609A, TYR609C, TYR610A, TYR610C, TYR701A, TYR701C, TYR742A, TYR742C, TYR786A, TYR786C, TYR798A, TYR798C, TYR896A, TYR896C, TYR905A, TYR905C, TYR935A, TYR935C, TYR946A, TYR946C, VAL476A, VAL476C, VAL527A, VAL527C, VAL528A, VAL528C, VAL535A, VAL535C, VAL536A, VAL536C, VAL541A, VAL541C, VAL555A, VAL555C, VAL580A, VAL580C, VAL600A, VAL600C, VAL602A, VAL602C, VAL706A, VAL706C, VAL920A, VAL920C, VAL951A, VAL951C, VAL991A, VAL991C, VAL992A, VAL992C
• A-D: ALA1206D, ALA1207D, ALA1208D, ARG526A, ASN530A, ASN937A, ASP525A, ASP936A, GLN1204D, LEU1210D, LEU529A, LYS1205D, PHE1213D, PHE531A, PRO524A, PRO938A, SER944A, THR1211D, TYR935A, TYR946A
• A-E: ARG393A, ARG557E, ARG627E, ARG669A, ASN550E, ASP333A, ASP335A, ASP349A, ASP372A, ASP391A, ASP667A, GLN348A, GLU562E, GLY334A, ILE337A, ILE347A, LEU332A, LEU336A, LEU356A, LEU554E, LYS374A, LYS553E, LYS625E, MET559E, PRO549E, PRO556E, PRO661A, SER351A, SER558E, SER561E, THR353A, THR373A, THR394A, THR552E, THR560E, THR626E, TYR354A, TYR390A, TYR392A, VAL350A, VAL355A, VAL555E
• A-G: ALA829A, ALA829G, ALA833A, ALA833G, ARG120A, ARG120G, ARG317A, ARG317G, ARG393A, ARG393G, ARG676A, ARG676G, ARG72A, ARG72G, ARG761A, ARG761G, ARG823A, ARG823G, ARG834A, ARG834G, ARG836A, ARG836G, ARG99A, ARG99G, ASN112A, ASN112G, ASN115A, ASN115G, ASN41A, ASN41G, ASN77A, ASN77G, ASN820A, ASN820G, ASP310A, ASP310G, ASP316A, ASP316G, ASP349A, ASP349G, ASP391A, ASP391G, ASP60A, ASP60G, ASP674A, ASP674G, ASP756A, ASP756G, ASP758A, ASP758G, ASP811A, ASP811G, ASP846A, ASP846G, ASP850A, ASP850G, GLN348A, GLN348G, GLU114A, GLU114G, GLU117A, GLU117G, GLU312A, GLU312G, GLU315A, GLU315G, GLU360A, GLU813A, GLU813G, GLU827A, GLU827G, GLY113A, GLY113G, GLY116A, GLY116G, GLY309A, GLY309G, GLY352A, GLY352G, GLY395A, GLY395G, GLY812A, GLY812G, GLY818A, GLY818G, GLY830A, GLY830G, ILE118A, ILE118G, ILE121A, ILE121G, ILE318A, ILE318G, ILE319A, ILE319G, ILE321A, ILE321G, ILE347A, ILE347G, ILE74A, ILE74G, ILE810A, ILE810G, ILE821A, ILE821G, ILE835A, ILE835G, ILE849A, ILE849G, ILE851A, ILE851G, LEU311A, LEU311G, LEU356A, LEU356G, LEU678A, LEU678G, LEU78A, LEU78G, LEU825A, LEU825G, LEU847A, LEU847G, LYS119A, LYS119G, LYS357A, LYS357G, LYS396A, LYS396G, LYS675A, LYS675G, LYS726A, LYS726G, LYS73A, LYS73G, LYS757A, LYS757G, LYS828A, LYS828G, MET39A, MET39G, MET848A, MET848G, PHE110G, PHE346A, PHE346G, PRO314A, PRO314G, PRO359A, PRO359G, PRO40A, PRO40G, PRO677A, PRO677G, SER313A, SER313G, SER320A, SER320G, SER351A, SER351G, SER680A, SER680G, SER68A, SER68G, SER70A, SER70G, SER76A, SER76G, SER819A, SER819G, SER826A, SER826G, SER832A, SER832G, THR353A, THR353G, THR373A, THR394A, THR394G, THR673A, THR673G, THR71A, THR71G, THR814A, THR831A, THR831G, TRP62A, TRP62G, TYR109A, TYR109G, TYR111A, TYR111G, TYR123A, TYR123G, TYR354A, TYR354G, TYR390A, TYR390G, TYR392A, TYR392G, TYR798A, TYR798G, VAL355A, VAL355G, VAL358A, VAL358G, VAL679A, VAL679G, VAL75A, VAL75G, VAL815A, VAL815G, VAL824A, VAL824G
• A-I: ARG393I, ARG557A, ARG627A, ARG669I, ASN550A, ASP333I, ASP335I, ASP349I, ASP372I, ASP391I, ASP667I, GLN348I, GLU562A, GLY334I, GLY352I, ILE337I, ILE347I, LEU332I, LEU336I, LEU356I, LEU554A, LYS374I, LYS553A, LYS625A, MET559A, PHE346I, PRO549A, PRO551A, PRO556A, PRO661I, SER351I, SER558A, SER561A, THR353I, THR373I, THR394I, THR552A, THR560A, THR626A, TYR354I, TYR390I, TYR392I, VAL350I, VAL355I, VAL555A
• B-C: ALA1206B, ALA1207B, ALA1208B, ARG526C, ASN530C, ASN937C, ASP525C, ASP936C, GLN1204B, LEU1210B, LEU529C, LYS1205B, PHE1213B, PHE531C, PRO524C, PRO938C, SER944C, THR1211B, TYR935C, TYR946C
• C-D: ALA1012C, ALA1206D, ALA1207D, ALA1208D, ALA447C, ALA502C, ALA504C, ARG586C, ARG640C, ARG651C, ASP328C, ASP451C, ASP500C, ASP584C, ASP638C, ASP886C, ASP966C, ASP968C, GLN1008C, GLN1204D, GLN478C, GLN922C, GLU1010C, GLU1209D, GLU605C, GLU615C, GLY464C, GLY617C, GLY888C, GLY916C, GLY917C, GLY918C, GLY964C, GLY967C, GLY990C, GLY993C, HIS499C, HIS603C, HIS746C, ILE480C, ILE588C, ILE589C, ILE969C, ILE994C, LEU1210D, LEU515C, LEU636C, LEU639C, LEU923C, LYS1205D, LYS616C, LYS997C, MET448C, MET587C, MET887C, MET889C, PHE1011C, PHE1013C, PHE1212D, PHE1213D, PHE329C, PHE408C, PHE452C, PHE919C, PHE970C, PRO1009C, PRO503C, PRO614C, PRO996C, SER537C, SER599C, SER745C, SER921C, SER965C, THR1007C, THR1203D, THR1211D, THR450C, THR453C, THR637C, THR995C, TRP1014C, TRP988C, TYR501C, TYR514C, TYR517C, TYR585C, TYR598C, TYR609C, TYR748C, VAL600C, VAL920C, VAL991C, VAL992C
• C-G: ARG393G, ARG557C, ARG627C, ARG669G, ASN550C, ASP333G, ASP335G, ASP349G, ASP372G, ASP391G, ASP667G, GLN348G, GLU562C, GLY334G, GLY352G, ILE337G, ILE347G, LEU332G, LEU336G, LEU356G, LEU554C, LYS374G, LYS553C, LYS625C, MET559C, PHE346G, PRO549C, PRO551C, PRO556C, PRO661G, SER351G, SER558C, SER561C, THR353G, THR373G, THR394G, THR552C, THR560C, THR626C, TYR354G, TYR390G, TYR392G, VAL350G, VAL355G, VAL555C
• C-I: ALA829C, ALA829I, ALA833C, ALA833I, ARG120C, ARG120I, ARG317C, ARG317I, ARG393C, ARG393I, ARG676C, ARG676I, ARG72C, ARG72I, ARG761C, ARG761I, ARG823C, ARG823I, ARG834C, ARG834I, ARG836C, ARG836I, ARG99C, ARG99I, ASN112C, ASN112I, ASN115C, ASN115I, ASN41C, ASN41I, ASN77C, ASN77I, ASN820C, ASN820I, ASP310C, ASP310I, ASP316C, ASP316I, ASP349C, ASP349I, ASP391C, ASP391I, ASP60C, ASP60I, ASP674C, ASP674I, ASP756C, ASP756I, ASP758C, ASP758I, ASP811C, ASP811I, ASP846C, ASP846I, ASP850C, ASP850I, GLN348C, GLN348I, GLU114C, GLU114I, GLU117C, GLU117I, GLU312C, GLU312I, GLU315C, GLU315I, GLU360C, GLU813C, GLU813I, GLU827C, GLU827I, GLY113C, GLY113I, GLY116C, GLY116I, GLY309C, GLY309I, GLY352C, GLY352I, GLY395C, GLY395I, GLY812C, GLY812I, GLY818C, GLY818I, GLY830C, GLY830I, ILE118C, ILE118I, ILE121C, ILE121I, ILE318C, ILE318I, ILE319C, ILE319I, ILE321C, ILE321I, ILE347C, ILE347I, ILE74C, ILE74I, ILE810C, ILE810I, ILE821C, ILE821I, ILE835C, ILE835I, ILE849C, ILE849I, ILE851C, ILE851I, LEU311C, LEU311I, LEU356C, LEU356I, LEU678C, LEU678I, LEU78C, LEU78I, LEU825C, LEU825I, LEU847C, LEU847I, LYS119C, LYS119I, LYS357C, LYS357I, LYS396C, LYS396I, LYS675C, LYS675I, LYS726C, LYS726I, LYS73C, LYS73I, LYS757C, LYS757I, LYS828C, LYS828I, MET39C, MET39I, MET848C, MET848I, PHE110C, PHE110I, PHE346C, PHE346I, PRO314C, PRO314I, PRO359C, PRO359I, PRO40C, PRO40I, PRO677C, PRO677I, SER313C, SER313I, SER320C, SER320I, SER351C, SER351I, SER680C, SER680I, SER68C, SER68I, SER70C, SER70I, SER76C, SER76I, SER819C, SER819I, SER826C, SER826I, SER832C, SER832I, THR353C, THR353I, THR373C, THR394C, THR394I, THR673C, THR673I, THR71C, THR71I, THR814C, THR814I, THR831C, THR831I, TRP62C, TRP62I, TYR109C, TYR109I, TYR111C, TYR111I, TYR123C, TYR123I, TYR354C, TYR354I, TYR390C, TYR390I, TYR392C, TYR392I, TYR798C, TYR798I, VAL355C, VAL355I, VAL358C, VAL358I, VAL679C, VAL679I, VAL75C, VAL75I, VAL815C, VAL815I, VAL824C, VAL824I
• C-K: ARG393C, ARG557K, ARG627K, ARG669C, ASN550K, ASP333C, ASP335C, ASP349C, ASP372C, ASP391C, ASP667C, GLN348C, GLU562K, GLY334C, ILE337C, ILE347C, LEU332C, LEU336C, LEU356C, LEU554K, LYS374C, LYS553K, LYS625K, MET559K, PRO549K, PRO556K, PRO661C, SER351C, SER558K, SER561K, THR353C, THR373C, THR394C, THR552K, THR560K, THR626K, TYR354C, TYR390C, TYR392C, VAL350C, VAL355C, VAL555K
• E-F: ALA1012E, ALA1206F, ALA1207F, ALA1208F, ALA447E, ALA502E, ALA504E, ARG586E, ARG640E, ARG651E, ASP328E, ASP451E, ASP500E, ASP584E, ASP638E, ASP886E, ASP966E, ASP968E, GLN1008E, GLN1204F, GLN478E, GLN922E, GLU1010E, GLU1209F, GLU605E, GLU615E, GLY464E, GLY617E, GLY888E, GLY916E, GLY917E, GLY918E, GLY964E, GLY967E, GLY990E, GLY993E, HIS499E, HIS603E, HIS746E, ILE480E, ILE588E, ILE969E, ILE994E, LEU1210F, LEU515E, LEU636E, LEU639E, LEU923E, LYS1205F, LYS616E, LYS997E, MET448E, MET587E, MET750E, MET887E, MET889E, PHE1011E, PHE1013E, PHE1212F, PHE1213F, PHE329E, PHE408E, PHE452E, PHE919E, PHE970E, PRO1009E, PRO503E, PRO614E, PRO996E, SER537E, SER599E, SER745E, SER921E, SER965E, THR1007E, THR1203F, THR1211F, THR450E, THR453E, THR637E, THR995E, TRP1014E, TRP988E, TYR501E, TYR514E, TYR517E, TYR585E, TYR598E, TYR609E, TYR610E, TYR748E, VAL600E, VAL920E, VAL991E, VAL992E
• E-G: ALA1012E, ALA1012G, ALA1018E, ALA1018G, ALA447E, ALA447G, ALA479E, ALA479G, ALA492E, ALA492G, ALA493E, ALA493G, ALA607E, ALA607G, ALA608E, ALA608G, ALA697E, ALA697G, ALA705E, ALA705G, ALA707E, ALA707G, ALA783E, ALA783G, ARG1016E, ARG1016G, ARG425E, ARG425G, ARG443E, ARG443G, ARG445E, ARG445G, ARG518E, ARG518G, ARG526E, ARG526G, ARG557E, ARG557G, ARG574E, ARG574G, ARG586E, ARG586G, ARG698E, ARG698G, ARG834E, ARG834G, ARG836E, ARG836G, ARG845E, ARG845G, ARG861E, ARG861G, ARG868E, ARG868G, ARG897E, ARG897G, ARG932E, ARG932G, ARG939E, ARG939G, ARG940E, ARG940G, ARG952E, ARG952G, ASN406E, ASN406G, ASN423E, ASN423G, ASN497E, ASN497G, ASN530E, ASN530G, ASN550E, ASN550G, ASN569E, ASN569G, ASN579E, ASN579G, ASN700E, ASN700G, ASN703E, ASN703G, ASN788E, ASN788G, ASN893E, ASN893G, ASN901E, ASN901G, ASN930E, ASN930G, ASN937E, ASN937G, ASN949E, ASN949G, ASP1017E, ASP1017G, ASP424E, ASP424G, ASP473E, ASP473G, ASP500E, ASP500G, ASP521E, ASP521G, ASP525E, ASP525G, ASP567E, ASP570E, ASP570G, ASP581E, ASP581G, ASP584E, ASP584G, ASP699E, ASP699G, ASP785E, ASP785G, ASP801E, ASP801G, ASP846E, ASP846G, ASP850E, ASP850G, ASP936E, ASP936G, ASP966E, ASP966G, GLN1008E, GLN1008G, GLN478E, GLN478G, GLN922E, GLN922G, GLU1010E, GLU1010G, GLU446E, GLU446G, GLU471E, GLU471G, GLU496E, GLU496G, GLU534E, GLU534G, GLU562E, GLU562G, GLU605E, GLU605G, GLU615E, GLU615G, GLU704E, GLU704G, GLU789E, GLU789G, GLU791E, GLU791G, GLU797E, GLU797G, GLU865E, GLU865G, GLU894E, GLU894G, GLU902E, GLU902G, GLU926E, GLU926G, GLY1019E, GLY1019G, GLY470E, GLY470G, GLY474E, GLY474G, GLY547E, GLY547G, GLY583E, GLY583G, GLY604E, GLY604G, GLY784E, GLY784G, GLY790E, GLY790G, GLY799E, GLY799G, GLY888E, GLY888G, GLY891E, GLY891G, GLY934E, GLY934G, GLY941E, GLY941G, GLY953E, GLY953G, GLY978G, GLY993E, GLY993G, HIS469E, HIS469G, HIS499E, HIS499G, HIS603E, HIS603G, HIS872E, HIS872G, ILE480E, ILE480G, ILE542E, ILE542G, ILE545E, ILE545G, ILE578E, ILE578G, ILE795E, ILE795G, ILE800E, ILE800G, ILE849E, ILE849G, ILE900E, ILE900G, ILE924E, ILE924G, ILE925E, ILE925G, ILE933E, ILE933G, ILE969E, ILE969G, LEU467E, LEU467G, LEU520E, LEU520G, LEU529E, LEU529G, LEU696E, LEU696G, LEU847E, LEU847G, LEU852E, LEU852G, LEU892E, LEU892G, LEU898E, LEU898G, LEU923E, LEU923G, LEU928E, LEU928G, LEU943E, LEU943G, LEU977E, LEU977G, LEU979E, LEU979G, LYS468E, LYS468G, LYS538E, LYS538G, LYS553E, LYS553G, LYS573E, LYS573G, LYS616E, LYS616G, LYS695E, LYS695G, LYS708E, LYS708G, LYS792E, LYS792G, LYS844G, LYS927E, LYS927G, LYS931E, LYS931G, LYS975E, LYS976E, LYS976G, LYS997E, LYS997G, MET448E, MET448G, MET477E, MET477G, MET559E, MET559G, MET571E, MET571G, MET848E, MET848G, MET887E, MET887G, MET889E, MET889G, MET890E, MET890G, MET929E, MET929G, PHE1011E, PHE1011G, PHE1013E, PHE1013G, PHE1015E, PHE1015G, PHE1020E, PHE1020G, PHE408E, PHE408G, PHE426E, PHE426G, PHE531E, PHE531G, PHE533E, PHE533G, PHE540E, PHE540G, PHE606E, PHE606G, PHE796E, PHE796G, PHE857E, PHE857G, PHE895E, PHE895G, PHE899E, PHE899G, PHE919E, PHE919G, PHE970E, PHE970G, PHE972E, PHE972G, PHE974E, PHE974G, PRO1009E, PRO1009G, PRO522E, PRO522G, PRO524E, PRO524G, PRO539E, PRO539G, PRO543E, PRO543G, PRO546E, PRO546G, PRO549E, PRO549G, PRO556E, PRO556G, PRO577E, PRO577G, PRO582E, PRO582G, PRO601E, PRO601G, PRO794E, PRO794G, PRO802E, PRO802G, PRO938E, PRO938G, PRO945E, PRO945G, PRO947E, PRO947G, SER444E, SER444G, SER498E, SER498G, SER516E, SER516G, SER519E, SER519G, SER523E, SER523G, SER532E, SER532G, SER537E, SER537G, SER548E, SER548G, SER558E, SER558G, SER561E, SER561G, SER575E, SER575G, SER576E, SER576G, SER711E, SER787E, SER787G, SER793E, SER793G, SER832E, SER832G, SER903E, SER903G, SER904E, SER904G, SER921E, SER921G, SER944E, SER944G, SER950E, SER950G, SER971E, SER973E, SER973G, THR472E, THR472G, THR494E, THR494G, THR495E, THR495G, THR560E, THR560G, THR942E, THR942G, THR948E, THR948G, THR995E, TRP1014E, TRP1014G, TRP702E, TRP702G, TYR475E, TYR475G, TYR501E, TYR501G, TYR514E, TYR514G, TYR517E, TYR517G, TYR572E, TYR572G, TYR585E, TYR585G, TYR609E, TYR609G, TYR610E, TYR610G, TYR701E, TYR701G, TYR742E, TYR742G, TYR786E, TYR786G, TYR798E, TYR798G, TYR896E, TYR896G, TYR905E, TYR905G, TYR935E, TYR935G, TYR946E, TYR946G, VAL476E, VAL476G, VAL527E, VAL527G, VAL528E, VAL528G, VAL535E, VAL535G, VAL536E, VAL536G, VAL541E, VAL541G, VAL555E, VAL555G, VAL580E, VAL580G, VAL600E, VAL600G, VAL602E, VAL602G, VAL706E, VAL706G, VAL920E, VAL920G, VAL951E, VAL951G, VAL991E, VAL991G, VAL992E, VAL992G
• E-H: ALA1206H, ALA1207H, ALA1208H, ARG526E, ASN530E, ASN937E, ASP525E, ASP936E, GLN1204H, LEU1210H, LEU529E, LYS1205H, PHE1213H, PHE531E, PRO524E, PRO938E, SER944E, THR1211H, TYR935E, TYR946E
• E-I: ARG393E, ARG557I, ARG627I, ARG669E, ASN550I, ASP333E, ASP335E, ASP349E, ASP372E, ASP391E, ASP667E, GLN348E, GLU562I, GLY334E, GLY395E, ILE337E, ILE347E, LEU332E, LEU336E, LEU356E, LEU554I, LYS374E, LYS553I, LYS625I, MET559I, PRO549I, PRO556I, PRO661E, SER351E, SER558I, SER561I, THR353E, THR373E, THR394E, THR552I, THR560I, THR626I, TYR354E, TYR390E, TYR392E, VAL350E, VAL355E, VAL555I
• E-K: ALA829E, ALA829K, ALA833E, ALA833K, ARG120E, ARG120K, ARG317E, ARG317K, ARG393E, ARG393K, ARG676E, ARG676K, ARG72E, ARG72K, ARG761E, ARG761K, ARG823E, ARG823K, ARG834E, ARG834K, ARG836E, ARG836K, ARG99E, ARG99K, ASN112E, ASN112K, ASN115E, ASN115K, ASN41E, ASN41K, ASN77E, ASN77K, ASN820E, ASN820K, ASP310E, ASP310K, ASP316E, ASP316K, ASP349E, ASP349K, ASP391E, ASP391K, ASP60E, ASP60K, ASP674E, ASP674K, ASP756E, ASP756K, ASP758E, ASP758K, ASP811E, ASP811K, ASP846E, ASP846K, ASP850E, ASP850K, GLN348E, GLN348K, GLU114E, GLU114K, GLU117E, GLU117K, GLU312E, GLU312K, GLU315E, GLU315K, GLU813E, GLU813K, GLU827E, GLU827K, GLY113E, GLY113K, GLY116E, GLY116K, GLY309E, GLY309K, GLY352E, GLY352K, GLY395E, GLY395K, GLY812E, GLY812K, GLY818E, GLY818K, GLY830E, GLY830K, ILE118E, ILE118K, ILE121E, ILE121K, ILE318E, ILE318K, ILE319E, ILE319K, ILE321E, ILE321K, ILE347E, ILE347K, ILE74E, ILE74K, ILE810E, ILE810K, ILE821E, ILE821K, ILE835E, ILE835K, ILE849E, ILE849K, ILE851E, ILE851K, LEU311E, LEU311K, LEU356E, LEU356K, LEU678E, LEU678K, LEU78E, LEU78K, LEU825E, LEU825K, LEU847E, LEU847K, LYS119E, LYS119K, LYS357E, LYS357K, LYS396E, LYS396K, LYS675E, LYS675K, LYS726E, LYS726K, LYS73E, LYS73K, LYS757E, LYS757K, LYS828E, LYS828K, MET39E, MET39K, MET848E, MET848K, PHE110E, PHE110K, PHE346E, PHE346K, PRO314E, PRO314K, PRO359E, PRO359K, PRO40E, PRO40K, PRO677E, PRO677K, SER313E, SER313K, SER320E, SER320K, SER351E, SER351K, SER680E, SER680K, SER68E, SER68K, SER70E, SER70K, SER76E, SER76K, SER819E, SER819K, SER826E, SER826K, SER832E, SER832K, THR353E, THR353K, THR373E, THR373K, THR394E, THR394K, THR673E, THR673K, THR71E, THR71K, THR831E, THR831K, TRP62E, TRP62K, TYR109E, TYR109K, TYR111E, TYR111K, TYR123E, TYR123K, TYR354E, TYR354K, TYR390E, TYR390K, TYR392E, TYR392K, TYR798E, TYR798K, VAL355E, VAL355K, VAL358E, VAL358K, VAL679E, VAL679K, VAL75E, VAL75K, VAL815E, VAL815K, VAL824E, VAL824K
• F-G: ALA1206F, ALA1207F, ALA1208F, ARG526G, ASN530G, ASN937G, ASP525G, ASP936G, GLN1204F, LEU1210F, LEU529G, LYS1205F, PHE1213F, PHE531G, PRO524G, PRO938G, SER944G, THR1211F, THR948G, TYR935G, TYR946G
• G-H: ALA1012G, ALA1206H, ALA1207H, ALA1208H, ALA447G, ALA502G, ALA504G, ARG586G, ARG640G, ARG651G, ASP328G, ASP451G, ASP500G, ASP584G, ASP638G, ASP886G, ASP966G, ASP968G, GLN1008G, GLN1204H, GLN478G, GLN922G, GLU1010G, GLU1209H, GLU605G, GLU615G, GLY464G, GLY617G, GLY888G, GLY916G, GLY917G, GLY918G, GLY964G, GLY967G, GLY990G, GLY993G, HIS499G, HIS603G, HIS746G, ILE480G, ILE588G, ILE589G, ILE969G, ILE994G, LEU1210H, LEU515G, LEU636G, LEU639G, LEU923G, LYS1205H, LYS616G, LYS997G, MET448G, MET587G, MET750G, MET887G, MET889G, PHE1011G, PHE1013G, PHE1212H, PHE1213H, PHE329G, PHE408G, PHE452G, PHE919G, PHE970G, PRO1009G, PRO503G, PRO614G, PRO996G, SER537G, SER599G, SER745G, SER921G, SER965G, THR1007G, THR1203H, THR1211H, THR450G, THR453G, THR637G, THR995G, TRP1014G, TRP988G, TYR501G, TYR514G, TYR517G, TYR585G, TYR598G, TYR609G, TYR748G, VAL600G, VAL920G, VAL991G, VAL992G
• G-K: ARG393K, ARG557G, ARG627G, ARG669K, ASN550G, ASP333K, ASP335K, ASP349K, ASP372K, ASP391K, ASP667K, GLN348K, GLU562G, GLY334K, ILE337K, ILE347K, LEU332K, LEU336K, LEU356K, LEU554G, LYS374K, LYS553G, LYS625G, MET559G, PRO549G, PRO556G, PRO661K, SER351K, SER558G, SER561G, THR353K, THR373K, THR394K, THR552G, THR560G, THR626G, TYR354K, TYR390K, TYR392K, VAL350K, VAL355K, VAL555G
• I-J: ALA1012I, ALA1206J, ALA1207J, ALA1208J, ALA447I, ALA502I, ALA504I, ARG586I, ARG640I, ARG651I, ASP328I, ASP451I, ASP500I, ASP584I, ASP638I, ASP886I, ASP966I, ASP968I, GLN1008I, GLN1204J, GLN478I, GLN922I, GLU1010I, GLU1209J, GLU605I, GLU615I, GLY464I, GLY617I, GLY888I, GLY916I, GLY917I, GLY918I, GLY964I, GLY967I, GLY990I, GLY993I, HIS499I, HIS603I, HIS746I, ILE480I, ILE588I, ILE589I, ILE969I, ILE994I, LEU1210J, LEU515I, LEU636I, LEU639I, LEU923I, LYS1205J, LYS616I, LYS997I, MET448I, MET587I, MET887I, MET889I, PHE1011I, PHE1013I, PHE1212J, PHE1213J, PHE329I, PHE408I, PHE452I, PHE919I, PHE970I, PRO1009I, PRO503I, PRO614I, PRO996I, SER537I, SER599I, SER745I, SER921I, SER965I, THR1007I, THR1203J, THR1211J, THR450I, THR453I, THR637I, THR995I, TRP1014I, TRP988I, TYR501I, TYR514I, TYR517I, TYR585I, TYR598I, TYR609I, TYR748I, VAL600I, VAL920I, VAL991I, VAL992I
• I-K: ALA1012I, ALA1012K, ALA1018I, ALA1018K, ALA447I, ALA447K, ALA479I, ALA479K, ALA492I, ALA492K, ALA493I, ALA493K, ALA607I, ALA607K, ALA608I, ALA608K, ALA697I, ALA697K, ALA705I, ALA705K, ALA707I, ALA707K, ALA783I, ALA783K, ARG1016I, ARG1016K, ARG425I, ARG425K, ARG443I, ARG443K, ARG445I, ARG445K, ARG518I, ARG518K, ARG526I, ARG526K, ARG557I, ARG557K, ARG574I, ARG574K, ARG586I, ARG586K, ARG698I, ARG698K, ARG834I, ARG834K, ARG836I, ARG836K, ARG845I, ARG845K, ARG861I, ARG861K, ARG868I, ARG868K, ARG897I, ARG897K, ARG932I, ARG932K, ARG939I, ARG939K, ARG940I, ARG940K, ARG952I, ARG952K, ASN406I, ASN406K, ASN423I, ASN423K, ASN497I, ASN497K, ASN530I, ASN530K, ASN550I, ASN550K, ASN569I, ASN569K, ASN579I, ASN579K, ASN700I, ASN700K, ASN703I, ASN703K, ASN788I, ASN788K, ASN893I, ASN893K, ASN901I, ASN901K, ASN930I, ASN930K, ASN937I, ASN937K, ASN949I, ASN949K, ASP1017I, ASP1017K, ASP424I, ASP424K, ASP473I, ASP473K, ASP500I, ASP500K, ASP521I, ASP521K, ASP525I, ASP525K, ASP567I, ASP567K, ASP570I, ASP570K, ASP581I, ASP581K, ASP584I, ASP584K, ASP699I, ASP699K, ASP785I, ASP785K, ASP801I, ASP801K, ASP846I, ASP846K, ASP850I, ASP850K, ASP936I, ASP936K, ASP966I, ASP966K, GLN1008I, GLN1008K, GLN478I, GLN478K, GLN922I, GLN922K, GLU1010I, GLU1010K, GLU446I, GLU446K, GLU471I, GLU471K, GLU496I, GLU496K, GLU534I, GLU534K, GLU562I, GLU562K, GLU605I, GLU605K, GLU615I, GLU615K, GLU704I, GLU704K, GLU789I, GLU789K, GLU791I, GLU791K, GLU797I, GLU797K, GLU865I, GLU865K, GLU894I, GLU894K, GLU902I, GLU902K, GLU926I, GLU926K, GLY1019I, GLY1019K, GLY470I, GLY470K, GLY474I, GLY474K, GLY547I, GLY547K, GLY583I, GLY583K, GLY604I, GLY604K, GLY784I, GLY784K, GLY790I, GLY790K, GLY799I, GLY799K, GLY888I, GLY888K, GLY891I, GLY891K, GLY934I, GLY934K, GLY941I, GLY941K, GLY953I, GLY953K, GLY993I, GLY993K, HIS469I, HIS469K, HIS499I, HIS499K, HIS603I, HIS603K, HIS872I, HIS872K, ILE480I, ILE480K, ILE542I, ILE542K, ILE545I, ILE545K, ILE578I, ILE578K, ILE795I, ILE795K, ILE800I, ILE800K, ILE849I, ILE849K, ILE900I, ILE900K, ILE924I, ILE924K, ILE925I, ILE925K, ILE933I, ILE933K, ILE969I, ILE969K, LEU467I, LEU467K, LEU520I, LEU520K, LEU529I, LEU529K, LEU696I, LEU696K, LEU847I, LEU847K, LEU852I, LEU852K, LEU892I, LEU892K, LEU898I, LEU898K, LEU923I, LEU923K, LEU928I, LEU928K, LEU943I, LEU943K, LEU977I, LEU977K, LEU979I, LEU979K, LYS468I, LYS468K, LYS538I, LYS538K, LYS553I, LYS553K, LYS573I, LYS573K, LYS616I, LYS616K, LYS695I, LYS695K, LYS708I, LYS708K, LYS792I, LYS792K, LYS844I, LYS927I, LYS927K, LYS931I, LYS931K, LYS976I, LYS976K, LYS997I, LYS997K, MET448I, MET448K, MET477I, MET477K, MET559I, MET559K, MET571I, MET571K, MET848I, MET848K, MET887I, MET887K, MET889I, MET889K, MET890I, MET890K, MET929I, MET929K, PHE1011I, PHE1011K, PHE1013I, PHE1013K, PHE1015I, PHE1015K, PHE1020I, PHE1020K, PHE408I, PHE408K, PHE426I, PHE426K, PHE531I, PHE531K, PHE533I, PHE533K, PHE540I, PHE540K, PHE606I, PHE606K, PHE796I, PHE796K, PHE857I, PHE857K, PHE895I, PHE895K, PHE899I, PHE899K, PHE919I, PHE919K, PHE970I, PHE970K, PHE972I, PHE972K, PHE974I, PHE974K, PRO1009I, PRO1009K, PRO522I, PRO522K, PRO524I, PRO524K, PRO539I, PRO539K, PRO543I, PRO543K, PRO546I, PRO546K, PRO549I, PRO549K, PRO556I, PRO556K, PRO577I, PRO577K, PRO582I, PRO582K, PRO601I, PRO601K, PRO794I, PRO794K, PRO802I, PRO802K, PRO938I, PRO938K, PRO945I, PRO945K, PRO947I, PRO947K, SER444I, SER444K, SER498I, SER498K, SER516I, SER516K, SER519I, SER519K, SER523I, SER523K, SER532I, SER532K, SER537I, SER537K, SER548I, SER548K, SER558I, SER558K, SER561I, SER561K, SER575I, SER575K, SER576I, SER576K, SER787I, SER787K, SER793I, SER793K, SER832I, SER832K, SER903I, SER903K, SER904I, SER904K, SER921I, SER921K, SER944I, SER944K, SER950I, SER950K, SER971K, SER973I, SER973K, THR472I, THR472K, THR494I, THR494K, THR495I, THR495K, THR560I, THR560K, THR942I, THR942K, THR948I, THR948K, THR995K, TRP1014I, TRP1014K, TRP702I, TRP702K, TYR475I, TYR475K, TYR501I, TYR501K, TYR514I, TYR514K, TYR517I, TYR517K, TYR572I, TYR572K, TYR585I, TYR585K, TYR609I, TYR609K, TYR610I, TYR610K, TYR701I, TYR701K, TYR742I, TYR742K, TYR786I, TYR786K, TYR798I, TYR798K, TYR896I, TYR896K, TYR905I, TYR905K, TYR935I, TYR935K, TYR946I, TYR946K, VAL476I, VAL476K, VAL527I, VAL527K, VAL528I, VAL528K, VAL535I, VAL535K, VAL536I, VAL536K, VAL541I, VAL541K, VAL555I, VAL555K, VAL580I, VAL580K, VAL600I, VAL600K, VAL602I, VAL602K, VAL706I, VAL706K, VAL920I, VAL920K, VAL951I, VAL951K, VAL991I, VAL991K, VAL992I, VAL992K
• I-L: ALA1206L, ALA1207L, ALA1208L, ARG526I, ASN530I, ASN937I, ASP525I, ASP936I, GLN1204L, LEU1210L, LEU529I, LYS1205L, PHE1213L, PHE531I, PRO524I, PRO938I, SER944I, THR1211L, THR948I, TYR935I, TYR946I
• J-K: ALA1206J, ALA1207J, ALA1208J, ARG526K, ASN530K, ASN937K, ASP525K, ASP936K, GLN1204J, LEU1210J, LEU529K, LYS1205J, PHE1213J, PHE531K, PRO524K, PRO938K, SER944K, THR1211J, TYR935K, TYR946K
• K-L: ALA1012K, ALA1206L, ALA1207L, ALA1208L, ALA447K, ALA502K, ALA504K, ARG586K, ARG640K, ARG651K, ASP328K, ASP451K, ASP500K, ASP584K, ASP638K, ASP886K, ASP966K, ASP968K, GLN1008K, GLN1204L, GLN478K, GLN922K, GLU1010K, GLU1209L, GLU605K, GLU615K, GLY464K, GLY617K, GLY888K, GLY916K, GLY917K, GLY918K, GLY964K, GLY967K, GLY990K, GLY993K, HIS499K, HIS603K, HIS746K, ILE480K, ILE588K, ILE589K, ILE969K, ILE994K, LEU1210L, LEU515K, LEU636K, LEU639K, LEU923K, LYS1205L, LYS616K, LYS997K, MET448K, MET587K, MET887K, MET889K, PHE1011K, PHE1013K, PHE1212L, PHE1213L, PHE329K, PHE408K, PHE452K, PHE919K, PHE970K, PRO1009K, PRO503K, PRO614K, PRO996K, SER537K, SER599K, SER745K, SER921K, SER965K, THR1007K, THR1203L, THR1211L, THR450K, THR453K, THR637K, THR995K, TRP1014K, TRP988K, TYR501K, TYR514K, TYR517K, TYR585K, TYR598K, TYR609K, TYR610K, TYR748K, VAL600K, VAL920K, VAL991K, VAL992K