1N6D

tricorn protease in complex with tetrapeptide chloromethyl ketone derivative

• Total interactions analyzed: 66
• Total true interactions: 24
• Strongest Interaction:
  • Chains: C-D
  • Int. Res.: 480
  • Norm. En. per Res.: -5.052
• Hub Node: A(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-G	-27.3463	-7.5687	25.787	-9.128	52	19	2	5102	2	16	7
A-B	-380.5447	-323.1932	-1754.73	-2458.4678	491	118	22	67055	19	175	187
A-H	-2.6081	-14.6242	-12.9701	-30.2025	20	3	0	668	2	4	1
A-C	-6.2388	25.4969	-83.6347	-64.3766	43	1	1	3414	0	21	7
A-D	-78.9002	-50.1658	-318.087	-447.153	204	14	0	14927	13	104	99
A-E	0.0	27.5372	-77.6224	-50.0852	46	14	1	3719	1	20	8
G-B	-2.6133	-14.4864	-12.2124	-29.3121	19	2	0	648	2	4	1
B-H	-27.0954	-7.5529	-63.0633	-97.7116	52	19	2	5101	2	16	7
B-D	0.0	31.6366	-85.1944	-53.5578	44	13	1	3580	0	19	8
B-E	-66.2693	-51.4988	-302.175	-419.9431	204	13	0	14598	12	106	100
B-F	-6.7733	23.5152	-76.8559	-60.114	42	1	0	3231	0	19	7
C-I	-26.6819	-7.5784	-8.87	-43.1303	52	18	2	5100	2	16	7
C-D	-355.5785	-342.9479	-1726.44	-2424.9664	480	97	23	66314	19	164	183
C-J	-2.7758	-13.6934	-13.1346	-29.6038	19	3	0	632	2	4	1
C-E	-5.9512	27.0616	-90.0997	-68.9893	43	10	1	3619	1	23	9
C-F	-74.1939	-62.7487	-319.011	-455.9537	212	5	0	15170	12	108	100
I-D	-2.9864	-14.07	-13.5063	-30.5627	20	3	0	653	2	4	1
D-J	-25.9526	-7.5524	1.9914	-31.5136	52	15	2	5082	2	16	7
D-F	-9.6005	26.0696	-83.9747	-67.5056	43	12	1	3520	1	23	8
E-K	-31.6736	-7.6056	5.3202	-33.959	52	16	2	5102	2	16	7
E-F	-338.151	-336.3592	-1681.66	-2356.1702	480	97	23	65510	18	165	182
E-L	-3.1016	-13.5833	-12.6506	-29.3355	18	4	0	635	2	4	1
K-F	-2.4428	-13.2918	-11.7163	-27.4509	17	2	0	590	2	4	1
F-L	-27.2762	-7.5246	-1.7055	-36.5063	52	18	2	5103	2	16	7

Interface residues

• A-G: ALA1012A, ALA608A, ARG1101G, ARG1103G, ARG131A, ASN915A, ASP886A, ASP966A, ASP968A, GLN611A, GLN922A, GLU1010A, GLU605A, GLY612A, GLY888A, GLY916A, GLY917A, GLY918A, GLY964A, GLY967A, GLY990A, GLY993A, HIS746A, ILE969A, ILE994A, LEU892A, LEU923A, LYS1104G, MET750A, MET887A, MET889A, PHE1011A, PHE1013A, PHE606A, PHE919A, PHE970A, PRO1009A, PRO996A, SER745A, SER921A, SER965A, THR1007A, THR995A, TRP1014A, TRP988A, TYR609A, TYR610A, TYR748A, VAL1102G, VAL920A, VAL991A, VAL992A
• A-B: ALA1012A, ALA1012B, ALA1018A, ALA1018B, ALA447A, ALA447B, ALA479A, ALA479B, ALA492A, ALA492B, ALA493A, ALA493B, ALA607A, ALA607B, ALA608A, ALA608B, ALA697A, ALA697B, ALA705A, ALA705B, ALA707A, ALA707B, ALA783A, ALA783B, ARG1016A, ARG1016B, ARG425A, ARG425B, ARG443A, ARG443B, ARG445A, ARG445B, ARG518A, ARG518B, ARG526A, ARG526B, ARG557A, ARG557B, ARG574A, ARG574B, ARG586A, ARG586B, ARG698A, ARG698B, ARG834A, ARG834B, ARG845A, ARG845B, ARG861A, ARG861B, ARG868A, ARG868B, ARG897A, ARG897B, ARG932A, ARG932B, ARG939A, ARG939B, ARG940A, ARG940B, ARG952A, ARG952B, ASN406A, ASN406B, ASN423A, ASN423B, ASN497A, ASN497B, ASN530A, ASN530B, ASN550A, ASN550B, ASN569A, ASN569B, ASN579A, ASN579B, ASN700A, ASN700B, ASN703A, ASN703B, ASN788A, ASN788B, ASN893A, ASN893B, ASN901A, ASN901B, ASN930A, ASN930B, ASN937A, ASN937B, ASN949A, ASN949B, ASP1017A, ASP1017B, ASP424A, ASP424B, ASP473A, ASP473B, ASP500A, ASP500B, ASP521A, ASP521B, ASP525A, ASP525B, ASP567A, ASP567B, ASP570A, ASP570B, ASP581A, ASP581B, ASP584A, ASP584B, ASP699A, ASP699B, ASP785A, ASP785B, ASP801A, ASP801B, ASP846A, ASP846B, ASP850A, ASP850B, ASP936A, ASP936B, ASP966A, ASP966B, ASP968A, ASP968B, GLN1008A, GLN1008B, GLN906A, GLN922A, GLN922B, GLU1010A, GLU1010B, GLU446A, GLU446B, GLU471A, GLU471B, GLU496A, GLU496B, GLU534A, GLU534B, GLU562A, GLU562B, GLU605A, GLU605B, GLU615A, GLU615B, GLU704A, GLU704B, GLU789A, GLU789B, GLU791A, GLU791B, GLU797A, GLU797B, GLU865A, GLU865B, GLU894A, GLU894B, GLU902A, GLU902B, GLU926A, GLU926B, GLY1019A, GLY1019B, GLY470A, GLY470B, GLY474A, GLY474B, GLY547A, GLY547B, GLY583A, GLY583B, GLY604A, GLY604B, GLY784A, GLY784B, GLY790A, GLY790B, GLY799A, GLY799B, GLY877A, GLY877B, GLY888A, GLY888B, GLY891A, GLY891B, GLY934A, GLY934B, GLY941A, GLY941B, GLY953A, GLY953B, GLY978A, GLY993A, GLY993B, HIS469A, HIS469B, HIS499A, HIS499B, HIS603A, HIS603B, HIS872A, HIS872B, ILE480A, ILE480B, ILE542A, ILE542B, ILE545A, ILE545B, ILE578A, ILE578B, ILE795A, ILE795B, ILE800A, ILE800B, ILE849A, ILE849B, ILE900A, ILE900B, ILE924A, ILE924B, ILE925A, ILE925B, ILE933A, ILE933B, ILE969A, ILE969B, LEU467A, LEU467B, LEU520A, LEU520B, LEU529A, LEU529B, LEU696A, LEU696B, LEU847A, LEU847B, LEU852A, LEU852B, LEU892A, LEU892B, LEU898A, LEU898B, LEU923A, LEU923B, LEU928A, LEU928B, LEU943A, LEU943B, LEU977A, LEU977B, LEU979A, LEU979B, LYS468A, LYS468B, LYS538A, LYS538B, LYS553A, LYS553B, LYS573A, LYS573B, LYS616A, LYS616B, LYS695A, LYS695B, LYS708A, LYS708B, LYS792A, LYS792B, LYS927A, LYS927B, LYS931A, LYS931B, LYS975A, LYS975B, LYS976A, LYS976B, LYS997A, LYS997B, MET448A, MET448B, MET477A, MET477B, MET559A, MET559B, MET571A, MET571B, MET848A, MET848B, MET887A, MET887B, MET889A, MET889B, MET890A, MET890B, MET929A, MET929B, PHE1011A, PHE1011B, PHE1013A, PHE1013B, PHE1015A, PHE1015B, PHE1020A, PHE1020B, PHE408B, PHE426A, PHE426B, PHE531A, PHE531B, PHE533A, PHE533B, PHE540A, PHE540B, PHE606A, PHE606B, PHE796A, PHE796B, PHE857A, PHE857B, PHE895A, PHE895B, PHE899A, PHE899B, PHE919A, PHE919B, PHE970A, PHE970B, PHE972A, PHE972B, PHE974A, PHE974B, PRO1009A, PRO1009B, PRO522A, PRO522B, PRO524A, PRO524B, PRO539A, PRO539B, PRO543A, PRO543B, PRO546A, PRO546B, PRO549A, PRO549B, PRO556A, PRO556B, PRO577A, PRO577B, PRO582A, PRO582B, PRO601A, PRO601B, PRO794A, PRO794B, PRO802A, PRO802B, PRO938A, PRO938B, PRO945A, PRO945B, PRO947A, PRO947B, SER444A, SER444B, SER498A, SER498B, SER516A, SER516B, SER519A, SER519B, SER523A, SER523B, SER532A, SER532B, SER537A, SER537B, SER548A, SER548B, SER558A, SER558B, SER561A, SER561B, SER575A, SER575B, SER576A, SER576B, SER711A, SER711B, SER787A, SER787B, SER793A, SER793B, SER832A, SER832B, SER903A, SER903B, SER904A, SER904B, SER921A, SER921B, SER944A, SER944B, SER950A, SER950B, SER971A, SER971B, SER973A, SER973B, THR472A, THR472B, THR494A, THR494B, THR495A, THR495B, THR560A, THR560B, THR942A, THR942B, THR948A, THR948B, TRP1014A, TRP1014B, TRP702A, TRP702B, TYR475A, TYR475B, TYR501A, TYR501B, TYR514A, TYR514B, TYR517A, TYR517B, TYR572A, TYR572B, TYR585A, TYR585B, TYR609A, TYR609B, TYR610A, TYR610B, TYR701A, TYR701B, TYR742A, TYR742B, TYR786A, TYR786B, TYR798A, TYR798B, TYR896A, TYR896B, TYR905A, TYR905B, TYR935A, TYR935B, TYR946A, TYR946B, VAL476A, VAL476B, VAL527A, VAL527B, VAL528A, VAL528B, VAL535A, VAL535B, VAL536A, VAL536B, VAL541A, VAL541B, VAL555A, VAL555B, VAL580A, VAL580B, VAL600A, VAL600B, VAL602A, VAL602B, VAL706A, VAL706B, VAL920A, VAL920B, VAL951A, VAL951B, VAL991A, VAL991B, VAL992A, VAL992B
• A-H: ARG1101H, ARG1103H, ARG526A, ASN530A, ASN937A, ASP525A, ASP936A, LEU529A, LYS1104H, PHE531A, PRO522A, PRO524A, PRO938A, PRO945A, SER523A, SER944A, TYR935A, TYR946A, VAL1102H, VAL528A
• A-C: ALA563C, ARG393A, ARG557C, ARG627C, ARG669A, ASN550C, ASP333A, ASP335A, ASP349A, ASP372A, ASP391A, ASP667A, GLN348A, GLU562C, GLY334A, ILE337A, ILE347A, LEU332A, LEU336A, LEU356A, LEU554C, LYS374A, LYS553C, LYS625C, MET559C, PRO549C, PRO556C, PRO661A, SER351A, SER558C, SER561C, THR353A, THR373A, THR394A, THR552C, THR560C, THR626C, TYR354A, TYR390A, TYR392A, VAL350A, VAL355A, VAL555C
• A-D: ALA829A, ALA829D, ALA833A, ALA833D, ARG120A, ARG120D, ARG317A, ARG317D, ARG393A, ARG393D, ARG676A, ARG676D, ARG72A, ARG72D, ARG761A, ARG761D, ARG823A, ARG823D, ARG834A, ARG834D, ARG836A, ARG836D, ARG99A, ARG99D, ASN112A, ASN112D, ASN115A, ASN115D, ASN41A, ASN41D, ASN77A, ASN77D, ASN820A, ASN820D, ASP310A, ASP310D, ASP316A, ASP316D, ASP349A, ASP349D, ASP391A, ASP391D, ASP60A, ASP60D, ASP674A, ASP674D, ASP756A, ASP756D, ASP811A, ASP811D, ASP846A, ASP846D, ASP850A, ASP850D, GLN348A, GLN348D, GLU114A, GLU114D, GLU117A, GLU117D, GLU312A, GLU312D, GLU315A, GLU315D, GLU813A, GLU813D, GLU827A, GLU827D, GLY113A, GLY113D, GLY116A, GLY116D, GLY309A, GLY309D, GLY352A, GLY352D, GLY395A, GLY395D, GLY69A, GLY69D, GLY79A, GLY79D, GLY812A, GLY812D, GLY818A, GLY818D, GLY830A, GLY830D, ILE118A, ILE118D, ILE121A, ILE121D, ILE318A, ILE318D, ILE319A, ILE319D, ILE347A, ILE74A, ILE74D, ILE810A, ILE810D, ILE821A, ILE821D, ILE835D, ILE849A, ILE849D, ILE851D, LEU311A, LEU311D, LEU336A, LEU356A, LEU356D, LEU678A, LEU678D, LEU78A, LEU78D, LEU825A, LEU825D, LEU847D, LYS119A, LYS119D, LYS357A, LYS357D, LYS675A, LYS675D, LYS726A, LYS726D, LYS73A, LYS73D, LYS757A, LYS757D, LYS828A, LYS828D, MET39A, MET39D, MET848A, MET848D, PHE110D, PHE346A, PHE346D, PRO314A, PRO314D, PRO359A, PRO359D, PRO40A, PRO40D, PRO677A, PRO677D, SER313A, SER313D, SER680A, SER680D, SER681A, SER68A, SER68D, SER70A, SER70D, SER76A, SER76D, SER819A, SER819D, SER826A, SER826D, SER832A, SER832D, THR353A, THR353D, THR373A, THR394A, THR394D, THR673A, THR71A, THR71D, THR814A, THR814D, THR831A, THR831D, TRP62A, TRP62D, TYR109A, TYR109D, TYR111A, TYR111D, TYR123A, TYR123D, TYR354A, TYR354D, TYR390A, TYR390D, TYR392A, TYR392D, TYR798A, TYR798D, VAL355A, VAL355D, VAL358A, VAL679A, VAL679D, VAL75A, VAL75D, VAL815A, VAL815D, VAL824A, VAL824D
• A-E: ALA563A, ARG393E, ARG557A, ARG627A, ARG669E, ASN550A, ASP333E, ASP335E, ASP349E, ASP372E, ASP391E, ASP667E, GLN348E, GLU562A, GLY334E, GLY352E, ILE337E, ILE347E, LEU332E, LEU336E, LEU356E, LEU554A, LYS357E, LYS553A, LYS625A, MET559A, PHE346E, PRO549A, PRO551A, PRO556A, PRO661E, SER351E, SER558A, SER561A, THR353E, THR373E, THR394E, THR552A, THR560A, THR626A, TYR354E, TYR390E, TYR392E, VAL350E, VAL355E, VAL555A
• G-B: ARG1101G, ARG526B, ASN530B, ASN937B, ASP525B, ASP936B, LEU529B, LYS1104G, PHE531B, PRO522B, PRO524B, PRO938B, PRO945B, SER523B, SER944B, TYR935B, TYR946B, VAL1102G, VAL528B
• B-H: ALA1012B, ALA608B, ARG1101H, ARG1103H, ARG131B, ASN915B, ASP886B, ASP966B, ASP968B, GLN611B, GLN922B, GLU1010B, GLU605B, GLY612B, GLY888B, GLY916B, GLY917B, GLY918B, GLY964B, GLY967B, GLY990B, GLY993B, HIS746B, ILE969B, ILE994B, LEU892B, LEU923B, LYS1104H, MET750B, MET887B, MET889B, PHE1011B, PHE1013B, PHE606B, PHE919B, PHE970B, PRO1009B, PRO996B, SER745B, SER921B, SER965B, THR1007B, THR995B, TRP1014B, TRP988B, TYR609B, TYR610B, TYR748B, VAL1102H, VAL920B, VAL991B, VAL992B
• B-D: ALA563B, ARG393D, ARG557B, ARG627B, ARG669D, ASN550B, ASP333D, ASP335D, ASP349D, ASP372D, ASP391D, ASP667D, GLN348D, GLU562B, GLY334D, GLY352D, ILE337D, ILE347D, LEU332D, LEU336D, LEU356D, LEU554B, LYS553B, LYS625B, MET559B, PHE346D, PRO549B, PRO551B, PRO556B, PRO661D, SER351D, SER558B, SER561B, THR353D, THR373D, THR394D, THR552B, THR560B, THR626B, TYR354D, TYR392D, VAL350D, VAL355D, VAL555B
• B-E: ALA829B, ALA829E, ALA833B, ALA833E, ARG120B, ARG120E, ARG317B, ARG317E, ARG393B, ARG393E, ARG676B, ARG676E, ARG72B, ARG72E, ARG761B, ARG761E, ARG823B, ARG823E, ARG834B, ARG834E, ARG836B, ARG836E, ARG99B, ARG99E, ASN112B, ASN112E, ASN115B, ASN115E, ASN41B, ASN41E, ASN77B, ASN77E, ASN820B, ASN820E, ASP310B, ASP310E, ASP316B, ASP316E, ASP349B, ASP391B, ASP391E, ASP60B, ASP60E, ASP674B, ASP674E, ASP756B, ASP756E, ASP758E, ASP811B, ASP811E, ASP846B, ASP846E, ASP850B, ASP850E, GLN348B, GLN348E, GLU114B, GLU114E, GLU117B, GLU117E, GLU312B, GLU312E, GLU315B, GLU315E, GLU813B, GLU813E, GLU827B, GLU827E, GLY113B, GLY113E, GLY116B, GLY116E, GLY309B, GLY309E, GLY352B, GLY352E, GLY395B, GLY395E, GLY69B, GLY69E, GLY79B, GLY79E, GLY812B, GLY812E, GLY818B, GLY818E, GLY830B, GLY830E, ILE118B, ILE118E, ILE121B, ILE121E, ILE318B, ILE318E, ILE319B, ILE319E, ILE321B, ILE347B, ILE74B, ILE74E, ILE810B, ILE810E, ILE821E, ILE835E, ILE849B, ILE849E, ILE851E, LEU311B, LEU311E, LEU336B, LEU356B, LEU356E, LEU678B, LEU678E, LEU78B, LEU78E, LEU825B, LEU825E, LEU847E, LYS119B, LYS119E, LYS357B, LYS357E, LYS675B, LYS675E, LYS726B, LYS726E, LYS73B, LYS73E, LYS757B, LYS757E, LYS828B, LYS828E, MET39B, MET39E, MET848B, MET848E, PHE110E, PHE346B, PHE346E, PRO314B, PRO314E, PRO359B, PRO359E, PRO40B, PRO40E, PRO677B, PRO677E, SER313B, SER313E, SER351B, SER680B, SER680E, SER68B, SER68E, SER70B, SER70E, SER76B, SER76E, SER819B, SER819E, SER826B, SER826E, SER832B, SER832E, THR353B, THR353E, THR373B, THR394B, THR394E, THR673B, THR71B, THR71E, THR755B, THR814E, THR831B, THR831E, TRP62B, TRP62E, TYR109B, TYR109E, TYR111B, TYR111E, TYR123B, TYR123E, TYR354B, TYR354E, TYR390B, TYR390E, TYR392B, TYR392E, TYR798B, TYR798E, VAL355B, VAL355E, VAL358B, VAL679B, VAL679E, VAL75B, VAL75E, VAL815B, VAL815E, VAL824B, VAL824E
• B-F: ALA563F, ARG393B, ARG557F, ARG627F, ARG669B, ASN550F, ASP333B, ASP335B, ASP349B, ASP372B, ASP391B, ASP667B, GLN348B, GLU562F, GLY334B, ILE337B, ILE347B, LEU332B, LEU336B, LEU356B, LEU554F, LYS374B, LYS553F, LYS625F, MET559F, PRO549F, PRO556F, PRO661B, SER351B, SER558F, SER561F, THR353B, THR373B, THR394B, THR552F, THR560F, THR626F, TYR354B, TYR392B, VAL350B, VAL355B, VAL555F
• C-I: ALA1012C, ALA608C, ARG1101I, ARG1103I, ARG131C, ASN915C, ASP886C, ASP966C, ASP968C, GLN611C, GLN922C, GLU1010C, GLU605C, GLY612C, GLY888C, GLY916C, GLY917C, GLY918C, GLY964C, GLY967C, GLY990C, GLY993C, HIS746C, ILE969C, ILE994C, LEU892C, LEU923C, LYS1104I, MET750C, MET887C, MET889C, PHE1011C, PHE1013C, PHE606C, PHE919C, PHE970C, PRO1009C, PRO996C, SER745C, SER921C, SER965C, THR1007C, THR995C, TRP1014C, TRP988C, TYR609C, TYR610C, TYR748C, VAL1102I, VAL920C, VAL991C, VAL992C
• C-D: ALA1012C, ALA1012D, ALA1018C, ALA1018D, ALA447C, ALA447D, ALA479D, ALA492C, ALA492D, ALA493C, ALA493D, ALA607C, ALA607D, ALA608C, ALA608D, ALA697C, ALA697D, ALA705C, ALA705D, ALA707C, ALA707D, ALA783C, ALA783D, ARG1016C, ARG1016D, ARG425C, ARG425D, ARG443C, ARG443D, ARG445C, ARG445D, ARG518C, ARG518D, ARG526C, ARG526D, ARG557C, ARG557D, ARG574C, ARG574D, ARG586C, ARG586D, ARG698C, ARG698D, ARG834C, ARG834D, ARG845C, ARG845D, ARG861C, ARG861D, ARG868C, ARG868D, ARG897C, ARG897D, ARG932C, ARG932D, ARG939C, ARG939D, ARG940C, ARG940D, ARG952C, ARG952D, ASN406C, ASN406D, ASN423C, ASN423D, ASN497C, ASN497D, ASN530C, ASN530D, ASN550C, ASN550D, ASN569C, ASN569D, ASN579C, ASN579D, ASN700C, ASN700D, ASN703C, ASN703D, ASN788C, ASN788D, ASN893C, ASN893D, ASN901C, ASN901D, ASN930C, ASN930D, ASN937C, ASN937D, ASN949C, ASN949D, ASP1017C, ASP1017D, ASP424C, ASP424D, ASP473C, ASP473D, ASP500C, ASP500D, ASP521C, ASP521D, ASP525C, ASP525D, ASP567C, ASP567D, ASP570C, ASP570D, ASP581C, ASP581D, ASP584C, ASP584D, ASP699C, ASP699D, ASP785C, ASP785D, ASP801C, ASP801D, ASP846C, ASP846D, ASP850C, ASP850D, ASP936C, ASP936D, ASP966C, ASP966D, GLN1008C, GLN1008D, GLN478C, GLN922C, GLN922D, GLU1010C, GLU1010D, GLU446C, GLU446D, GLU471C, GLU471D, GLU496C, GLU496D, GLU534C, GLU534D, GLU562C, GLU562D, GLU605C, GLU605D, GLU615C, GLU615D, GLU704C, GLU704D, GLU789C, GLU789D, GLU791C, GLU791D, GLU797C, GLU797D, GLU865C, GLU865D, GLU894C, GLU894D, GLU902C, GLU902D, GLU926C, GLU926D, GLY1019C, GLY1019D, GLY470C, GLY470D, GLY474C, GLY474D, GLY547C, GLY547D, GLY583C, GLY583D, GLY604C, GLY604D, GLY784C, GLY784D, GLY790C, GLY790D, GLY799C, GLY799D, GLY877C, GLY877D, GLY888C, GLY888D, GLY891C, GLY891D, GLY934C, GLY934D, GLY941C, GLY941D, GLY953C, GLY953D, GLY993C, GLY993D, HIS469C, HIS469D, HIS499C, HIS499D, HIS603C, HIS603D, HIS872C, HIS872D, ILE480C, ILE480D, ILE542C, ILE542D, ILE545C, ILE545D, ILE578C, ILE578D, ILE795C, ILE795D, ILE800C, ILE800D, ILE849C, ILE849D, ILE900C, ILE900D, ILE924C, ILE924D, ILE925C, ILE925D, ILE933C, ILE933D, ILE969C, ILE969D, LEU467C, LEU467D, LEU520C, LEU520D, LEU529C, LEU529D, LEU696C, LEU696D, LEU847C, LEU847D, LEU852C, LEU852D, LEU892C, LEU892D, LEU898C, LEU898D, LEU923C, LEU923D, LEU928C, LEU928D, LEU943C, LEU943D, LEU977C, LEU977D, LEU979C, LYS468C, LYS468D, LYS538C, LYS538D, LYS553C, LYS553D, LYS573C, LYS573D, LYS616C, LYS616D, LYS695C, LYS695D, LYS708C, LYS708D, LYS792C, LYS792D, LYS927C, LYS927D, LYS931C, LYS931D, LYS976C, LYS976D, LYS997C, LYS997D, MET448C, MET448D, MET477C, MET477D, MET559C, MET559D, MET571C, MET571D, MET848C, MET848D, MET887C, MET887D, MET889C, MET889D, MET890C, MET890D, MET929C, MET929D, PHE1011C, PHE1011D, PHE1013C, PHE1013D, PHE1015C, PHE1015D, PHE1020C, PHE1020D, PHE408C, PHE408D, PHE426C, PHE426D, PHE531C, PHE531D, PHE533C, PHE533D, PHE540C, PHE540D, PHE606C, PHE606D, PHE796C, PHE796D, PHE857C, PHE857D, PHE895C, PHE895D, PHE899C, PHE899D, PHE919C, PHE919D, PHE970C, PHE970D, PHE972C, PHE972D, PHE974C, PHE974D, PRO1009C, PRO1009D, PRO522C, PRO522D, PRO524C, PRO524D, PRO539C, PRO539D, PRO543C, PRO543D, PRO546C, PRO546D, PRO549C, PRO549D, PRO556C, PRO556D, PRO577C, PRO577D, PRO582C, PRO582D, PRO601C, PRO601D, PRO794C, PRO794D, PRO938C, PRO938D, PRO945C, PRO945D, PRO947C, PRO947D, SER444C, SER444D, SER498C, SER498D, SER516C, SER516D, SER519C, SER519D, SER523C, SER523D, SER532C, SER532D, SER537C, SER537D, SER548C, SER548D, SER558C, SER558D, SER561C, SER561D, SER575C, SER575D, SER576C, SER576D, SER787C, SER787D, SER793C, SER793D, SER832C, SER832D, SER903C, SER903D, SER904C, SER904D, SER921C, SER921D, SER944C, SER944D, SER950C, SER950D, SER971C, SER973C, SER973D, THR472C, THR472D, THR494C, THR494D, THR495C, THR495D, THR560C, THR560D, THR942C, THR942D, THR948C, THR948D, TRP1014C, TRP1014D, TRP702C, TRP702D, TYR475C, TYR475D, TYR501C, TYR501D, TYR514C, TYR514D, TYR517C, TYR517D, TYR572C, TYR572D, TYR585C, TYR585D, TYR609C, TYR609D, TYR610C, TYR610D, TYR701C, TYR701D, TYR742C, TYR742D, TYR786C, TYR786D, TYR798C, TYR798D, TYR896C, TYR896D, TYR905C, TYR905D, TYR935C, TYR935D, TYR946C, TYR946D, VAL476C, VAL476D, VAL527C, VAL527D, VAL528C, VAL528D, VAL535C, VAL535D, VAL536C, VAL536D, VAL541C, VAL541D, VAL555C, VAL555D, VAL580C, VAL580D, VAL600C, VAL600D, VAL602C, VAL602D, VAL706C, VAL706D, VAL920C, VAL920D, VAL951C, VAL951D, VAL991C, VAL991D, VAL992C, VAL992D
• C-J: ARG1101J, ARG1103J, ARG526C, ASN530C, ASN937C, ASP525C, ASP936C, LEU529C, LYS1104J, PHE531C, PRO522C, PRO524C, PRO938C, SER523C, SER944C, TYR935C, TYR946C, VAL1102J, VAL528C
• C-E: ALA563E, ARG393C, ARG557E, ARG627E, ARG669C, ASN550E, ASP333C, ASP335C, ASP349C, ASP372C, ASP391C, ASP667C, GLN348C, GLU562E, GLY334C, ILE337C, ILE347C, LEU332C, LEU336C, LEU356C, LEU554E, LYS374C, LYS553E, LYS625E, MET559E, PRO549E, PRO556E, PRO661C, SER351C, SER558E, SER561E, THR353C, THR373C, THR394C, THR552E, THR560E, THR626E, TYR354C, TYR390C, TYR392C, VAL350C, VAL355C, VAL555E
• C-F: ALA829C, ALA829F, ALA833C, ALA833F, ARG120C, ARG120F, ARG317C, ARG317F, ARG393C, ARG393F, ARG676C, ARG676F, ARG72C, ARG72F, ARG761C, ARG761F, ARG823C, ARG823F, ARG834C, ARG834F, ARG836C, ARG836F, ARG99C, ARG99F, ASN112C, ASN112F, ASN115C, ASN115F, ASN41C, ASN41F, ASN77C, ASN77F, ASN820C, ASN820F, ASP310C, ASP310F, ASP316C, ASP316F, ASP349C, ASP349F, ASP391C, ASP391F, ASP60C, ASP60F, ASP674C, ASP674F, ASP756C, ASP756F, ASP758C, ASP758F, ASP811C, ASP811F, ASP846C, ASP846F, ASP850C, ASP850F, GLN348C, GLN348F, GLU114C, GLU114F, GLU117C, GLU117F, GLU312C, GLU312F, GLU315C, GLU315F, GLU813C, GLU813F, GLU827C, GLU827F, GLY113C, GLY113F, GLY116C, GLY116F, GLY309C, GLY309F, GLY352C, GLY352F, GLY395C, GLY395F, GLY69C, GLY69F, GLY79C, GLY79F, GLY812C, GLY812F, GLY818C, GLY818F, GLY830C, GLY830F, ILE118C, ILE118F, ILE121C, ILE121F, ILE318C, ILE318F, ILE319C, ILE319F, ILE321C, ILE321F, ILE347C, ILE347F, ILE74C, ILE74F, ILE810C, ILE810F, ILE821C, ILE821F, ILE835C, ILE849C, ILE849F, ILE851C, ILE851F, LEU311C, LEU311F, LEU336C, LEU336F, LEU356C, LEU356F, LEU678C, LEU678F, LEU78C, LEU78F, LEU825C, LEU825F, LYS119C, LYS119F, LYS357C, LYS357F, LYS396F, LYS675C, LYS675F, LYS726C, LYS726F, LYS73C, LYS73F, LYS757C, LYS757F, LYS828C, LYS828F, MET39C, MET39F, MET848C, MET848F, PHE110C, PHE110F, PHE346C, PHE346F, PRO314C, PRO314F, PRO359C, PRO359F, PRO40C, PRO40F, PRO677C, PRO677F, SER313C, SER313F, SER680C, SER680F, SER68C, SER68F, SER70C, SER70F, SER76C, SER76F, SER819C, SER819F, SER826C, SER826F, SER832C, SER832F, THR353C, THR353F, THR373C, THR373F, THR394C, THR394F, THR673C, THR673F, THR71C, THR71F, THR831C, THR831F, TRP62C, TRP62F, TYR109C, TYR109F, TYR111C, TYR111F, TYR123C, TYR123F, TYR354C, TYR354F, TYR390C, TYR390F, TYR392C, TYR392F, TYR798C, TYR798F, VAL355C, VAL355F, VAL358C, VAL358F, VAL679C, VAL679F, VAL75C, VAL75F, VAL815C, VAL815F, VAL824C, VAL824F
• I-D: ARG1101I, ARG1103I, ARG526D, ASN530D, ASN937D, ASP525D, ASP936D, LEU529D, LYS1104I, PHE531D, PRO522D, PRO524D, PRO938D, PRO945D, SER523D, SER944D, TYR935D, TYR946D, VAL1102I, VAL528D
• D-J: ALA1012D, ALA608D, ARG1101J, ARG1103J, ARG131D, ASN915D, ASP886D, ASP966D, ASP968D, GLN611D, GLN922D, GLU1010D, GLU605D, GLY612D, GLY888D, GLY916D, GLY917D, GLY918D, GLY964D, GLY967D, GLY990D, GLY993D, HIS746D, ILE969D, ILE994D, LEU892D, LEU923D, LYS1104J, MET750D, MET887D, MET889D, PHE1011D, PHE1013D, PHE606D, PHE919D, PHE970D, PRO1009D, PRO996D, SER745D, SER921D, SER965D, THR1007D, THR995D, TRP1014D, TRP988D, TYR609D, TYR610D, TYR748D, VAL1102J, VAL920D, VAL991D, VAL992D
• D-F: ALA563D, ARG393F, ARG557D, ARG627D, ARG669F, ASN550D, ASP333F, ASP335F, ASP349F, ASP372F, ASP391F, ASP667F, GLN348F, GLU562D, GLY334F, ILE337F, ILE347F, LEU332F, LEU336F, LEU356F, LEU554D, LYS374F, LYS553D, LYS625D, MET559D, PRO549D, PRO556D, PRO661F, SER351F, SER558D, SER561D, THR353F, THR373F, THR394F, THR552D, THR560D, THR626D, TYR354F, TYR390F, TYR392F, VAL350F, VAL355F, VAL555D
• E-K: ALA1012E, ALA608E, ARG1101K, ARG1103K, ARG131E, ASN915E, ASP886E, ASP966E, ASP968E, GLN611E, GLN922E, GLU1010E, GLU605E, GLY612E, GLY888E, GLY916E, GLY917E, GLY918E, GLY964E, GLY967E, GLY990E, GLY993E, HIS746E, ILE969E, ILE994E, LEU892E, LEU923E, LYS1104K, MET750E, MET887E, MET889E, PHE1011E, PHE1013E, PHE606E, PHE919E, PHE970E, PRO1009E, PRO996E, SER745E, SER921E, SER965E, THR1007E, THR995E, TRP1014E, TRP988E, TYR609E, TYR610E, TYR748E, VAL1102K, VAL920E, VAL991E, VAL992E
• E-F: ALA1012E, ALA1012F, ALA1018E, ALA1018F, ALA447E, ALA447F, ALA479E, ALA492E, ALA492F, ALA493E, ALA493F, ALA607E, ALA607F, ALA608E, ALA608F, ALA697E, ALA697F, ALA705E, ALA705F, ALA707E, ALA707F, ALA783E, ALA783F, ARG1016E, ARG1016F, ARG425E, ARG425F, ARG443E, ARG443F, ARG445E, ARG445F, ARG518E, ARG518F, ARG526E, ARG526F, ARG557E, ARG557F, ARG574E, ARG574F, ARG586E, ARG586F, ARG627F, ARG698E, ARG698F, ARG834E, ARG834F, ARG845E, ARG845F, ARG861E, ARG861F, ARG868E, ARG868F, ARG897E, ARG897F, ARG932E, ARG932F, ARG939E, ARG939F, ARG940E, ARG940F, ARG952E, ARG952F, ASN406E, ASN406F, ASN423E, ASN423F, ASN497E, ASN497F, ASN530E, ASN530F, ASN550E, ASN550F, ASN569E, ASN569F, ASN579E, ASN579F, ASN700E, ASN700F, ASN703E, ASN703F, ASN788E, ASN788F, ASN893E, ASN893F, ASN901E, ASN901F, ASN930E, ASN930F, ASN937E, ASN937F, ASN949E, ASN949F, ASP1017E, ASP1017F, ASP424E, ASP424F, ASP473E, ASP473F, ASP500E, ASP500F, ASP521E, ASP521F, ASP525E, ASP525F, ASP567E, ASP567F, ASP570E, ASP570F, ASP581E, ASP581F, ASP584E, ASP584F, ASP699E, ASP699F, ASP785E, ASP785F, ASP801E, ASP801F, ASP846E, ASP846F, ASP850E, ASP850F, ASP936E, ASP936F, ASP966E, ASP966F, GLN1008E, GLN1008F, GLN478F, GLN922E, GLN922F, GLU1010E, GLU1010F, GLU446E, GLU446F, GLU471E, GLU471F, GLU496E, GLU496F, GLU534E, GLU534F, GLU562E, GLU562F, GLU605E, GLU605F, GLU615E, GLU615F, GLU704E, GLU704F, GLU789E, GLU789F, GLU791E, GLU791F, GLU797E, GLU797F, GLU865E, GLU865F, GLU894E, GLU894F, GLU902E, GLU902F, GLU926E, GLU926F, GLY1019E, GLY1019F, GLY470E, GLY470F, GLY474E, GLY474F, GLY547E, GLY547F, GLY583E, GLY583F, GLY604E, GLY604F, GLY784E, GLY784F, GLY790E, GLY790F, GLY799E, GLY799F, GLY877E, GLY877F, GLY888E, GLY888F, GLY891E, GLY891F, GLY934E, GLY934F, GLY941E, GLY941F, GLY953E, GLY953F, GLY993E, GLY993F, HIS469E, HIS469F, HIS499E, HIS499F, HIS603E, HIS603F, HIS872E, HIS872F, ILE480E, ILE480F, ILE542E, ILE542F, ILE545E, ILE545F, ILE578E, ILE578F, ILE795E, ILE795F, ILE800E, ILE800F, ILE849E, ILE849F, ILE900E, ILE900F, ILE924E, ILE924F, ILE925E, ILE925F, ILE933E, ILE933F, ILE969E, ILE969F, LEU467E, LEU467F, LEU520E, LEU520F, LEU529E, LEU529F, LEU696E, LEU696F, LEU847E, LEU847F, LEU852E, LEU852F, LEU892E, LEU892F, LEU898E, LEU898F, LEU923E, LEU923F, LEU928E, LEU928F, LEU943E, LEU943F, LEU977E, LEU977F, LYS468E, LYS468F, LYS538E, LYS538F, LYS553E, LYS553F, LYS573E, LYS573F, LYS616E, LYS616F, LYS695E, LYS695F, LYS708E, LYS708F, LYS792E, LYS792F, LYS927E, LYS927F, LYS931E, LYS931F, LYS976E, LYS976F, LYS997E, LYS997F, MET448E, MET448F, MET477E, MET477F, MET559E, MET559F, MET571E, MET571F, MET848E, MET848F, MET887E, MET887F, MET889E, MET889F, MET890E, MET890F, MET929E, MET929F, PHE1011E, PHE1011F, PHE1013E, PHE1013F, PHE1015E, PHE1015F, PHE1020E, PHE1020F, PHE408E, PHE408F, PHE426E, PHE426F, PHE531E, PHE531F, PHE533E, PHE533F, PHE540E, PHE540F, PHE606E, PHE606F, PHE796E, PHE796F, PHE857E, PHE857F, PHE895E, PHE895F, PHE899E, PHE899F, PHE919E, PHE919F, PHE970E, PHE970F, PHE972E, PHE972F, PHE974E, PHE974F, PRO1009E, PRO1009F, PRO522E, PRO522F, PRO524E, PRO524F, PRO539E, PRO539F, PRO543E, PRO543F, PRO546E, PRO546F, PRO549E, PRO549F, PRO556E, PRO556F, PRO577E, PRO577F, PRO582E, PRO582F, PRO601E, PRO601F, PRO794E, PRO794F, PRO938E, PRO938F, PRO945E, PRO945F, PRO947E, PRO947F, SER444E, SER444F, SER498E, SER498F, SER516E, SER516F, SER519E, SER519F, SER523E, SER523F, SER532E, SER532F, SER537E, SER537F, SER548E, SER548F, SER558E, SER558F, SER561E, SER561F, SER575E, SER575F, SER576E, SER576F, SER787E, SER787F, SER793E, SER793F, SER832E, SER832F, SER903E, SER903F, SER904E, SER904F, SER921E, SER921F, SER944E, SER944F, SER950E, SER950F, SER971F, SER973E, SER973F, THR472E, THR472F, THR494E, THR494F, THR495E, THR495F, THR560E, THR560F, THR942E, THR942F, THR948E, THR948F, TRP1014E, TRP1014F, TRP702E, TRP702F, TYR475E, TYR475F, TYR501E, TYR501F, TYR514E, TYR514F, TYR517E, TYR517F, TYR572E, TYR572F, TYR585E, TYR585F, TYR609E, TYR609F, TYR610E, TYR610F, TYR701E, TYR701F, TYR742E, TYR742F, TYR786E, TYR786F, TYR798E, TYR798F, TYR896E, TYR896F, TYR905E, TYR905F, TYR935E, TYR935F, TYR946E, TYR946F, VAL476E, VAL476F, VAL527E, VAL527F, VAL528E, VAL528F, VAL535E, VAL535F, VAL536E, VAL536F, VAL541E, VAL541F, VAL555E, VAL555F, VAL580E, VAL580F, VAL600E, VAL600F, VAL602E, VAL602F, VAL706E, VAL706F, VAL920E, VAL920F, VAL951E, VAL951F, VAL991E, VAL991F, VAL992E, VAL992F
• E-L: ARG1101L, ARG1103L, ARG526E, ASN530E, ASN937E, ASP525E, ASP936E, LEU529E, LYS1104L, PHE531E, PRO522E, PRO524E, PRO938E, SER523E, SER944E, TYR935E, TYR946E, VAL1102L
• K-F: ARG1101K, ARG526F, ASN530F, ASN937F, ASP525F, ASP936F, LEU529F, LYS1104K, PHE531F, PRO522F, PRO524F, PRO938F, SER523F, SER944F, TYR935F, TYR946F, VAL1102K
• F-L: ALA1012F, ALA608F, ARG1101L, ARG1103L, ARG131F, ASN915F, ASP886F, ASP966F, ASP968F, GLN611F, GLN922F, GLU1010F, GLU605F, GLY612F, GLY888F, GLY916F, GLY917F, GLY918F, GLY964F, GLY967F, GLY990F, GLY993F, HIS746F, ILE969F, ILE994F, LEU892F, LEU923F, LYS1104L, MET750F, MET887F, MET889F, PHE1011F, PHE1013F, PHE606F, PHE919F, PHE970F, PRO1009F, PRO996F, SER745F, SER921F, SER965F, THR1007F, THR995F, TRP1014F, TRP988F, TYR609F, TYR610F, TYR748F, VAL1102L, VAL920F, VAL991F, VAL992F