1N3T

biosynthesis of pteridins. reaction mechanism of gtp cyclohydrolase i

• Total interactions analyzed: 105
• Total true interactions: 35
• Strongest Interaction:
  • Chains: J-N
  • Int. Res.: 184
  • Norm. En. per Res.: -4.4006
• Hub Node: F(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
F-G	-110.1186	-53.9246	-283.263	-447.3063	117	35	1	12095	9	40	54
F-J	-116.7144	-50.9605	-259.679	-427.3539	117	40	1	11784	9	41	55
F-L	0.0	0.0	-1.448	-1.448	12	0	1	265	0	4	6
F-M	-115.6061	-81.3333	-605.603	-802.5424	186	37	14	26082	10	64	56
F-N	-6.0035	-13.6979	-29.7535	-49.4548	43	2	0	1384	3	12	19
F-O	0.0	0.0	-0.0044	-0.0044	2	0	0	5	0	0	0
G-H	-98.077	-53.255	-245.302	-396.634	116	32	1	11766	9	40	54
G-K	0.0	0.0	-1.5639	-1.5639	12	0	1	272	0	4	6
G-L	-93.3643	-90.6504	-597.817	-781.8316	186	47	14	26146	9	63	55
G-M	-8.0881	-12.262	-35.6617	-56.0118	46	4	0	1672	4	14	19
G-N	0.0	0.0	-0.0056	-0.0056	2	0	0	9	0	0	0
H-I	-102.6278	-47.4778	-252.587	-402.6926	116	42	1	12107	9	40	54
H-K	-121.6872	-84.8765	-569.201	-775.7647	183	39	15	26114	10	64	55
H-L	-5.4318	-10.0494	-32.6298	-48.111	46	0	0	1525	3	13	19
H-M	0.0	0.0	-0.0051	-0.0051	2	0	0	6	0	0	0
H-O	0.0	0.0	-2.1314	-2.1314	12	0	1	289	0	4	6
I-J	-103.3375	-33.563	-257.733	-394.6336	115	31	1	11632	9	40	53
I-K	-4.0928	-8.0137	-32.6777	-44.7842	40	0	0	1484	3	14	19
I-L	0.0	0.0	-0.0086	-0.0086	2	0	0	9	0	0	0
I-N	0.0	-1.0625	-1.7988	-2.8613	11	0	1	270	0	4	6
I-O	-77.0707	-86.2977	-595.33	-758.6984	185	33	15	26003	10	64	54
J-K	0.0	0.0	-0.0057	-0.0057	2	0	0	8	0	0	0
J-M	0.0	0.0	-2.045	-2.045	12	0	1	295	0	4	6
J-N	-131.6033	-94.8392	-583.27	-809.7124	184	47	16	26310	10	64	55
J-O	-4.218	-13.3265	-33.1196	-50.6641	44	3	0	1495	3	13	19
K-L	-108.9208	-44.5351	-266.298	-419.754	119	32	1	12154	9	41	54
K-O	-101.3479	-39.5342	-268.322	-409.2041	117	34	1	12069	9	42	55
L-M	-104.9994	-52.4139	-277.971	-435.3843	116	39	1	12064	10	39	56
M-N	-104.9339	-43.4351	-262.771	-411.14	117	31	1	11915	10	39	54
N-O	-92.8831	-39.5484	-248.915	-381.3466	115	34	1	11701	7	40	54
A-B	-76.4144	-50.1125	-248.966	-375.4929	117	34	1	11606	9	39	53
A-E	-111.2112	-52.1865	-273.123	-436.5207	118	29	1	11833	9	42	55
B-C	-100.2774	-44.3393	-253.804	-398.4207	117	26	1	12077	8	39	55
C-D	-83.4812	-58.4656	-264.631	-406.5778	117	26	1	11782	10	41	55
D-E	-88.5701	-53.0996	-255.008	-396.6777	117	23	1	11463	9	40	54

Interface residues

• F-G: ALA121G, ALA124G, ALA16F, ALA177F, ALA190F, ALA193F, ALA216F, ALA216G, ARG102G, ARG139G, ARG153F, ARG17F, ARG185F, ARG188F, ARG210F, ARG210G, ARG215F, ARG215G, ARG218F, ASN138G, ASN208G, ASN221G, ASN91G, ASP103G, ASP176F, ASP189F, ASP96G, CYS110F, GLN142G, GLN151F, GLN156F, GLN157F, GLN207F, GLN207G, GLU111F, GLU152F, GLU20F, GLU212F, GLU212G, GLU90G, GLU97G, GLY119G, GLY133G, GLY186F, GLY18F, GLY200F, HIS112F, HIS113F, HIS179F, HIS211F, HIS211G, HIS219G, HIS220F, HIS220G, ILE104G, ILE117F, ILE126G, ILE132G, ILE137G, ILE140G, ILE160F, ILE175F, ILE187F, ILE89G, LEU106G, LEU134G, LEU154F, LEU159F, LEU199F, LEU19F, LEU214F, LEU88G, LYS120F, LYS120G, LYS136G, LYS183F, LYS204F, LYS92G, LYS94G, MET93G, MET98G, PHE143G, PHE203F, PHE213F, PHE213G, PRO127G, PRO22F, PRO84G, SER135G, SER181F, SER192F, SER198F, SER205F, SER206G, THR100G, THR105G, THR122G, THR155F, THR191F, THR194F, THR195F, THR196F, THR197F, THR209G, THR87G, TYR125G, VAL101G, VAL123G, VAL131G, VAL141G, VAL150F, VAL173F, VAL178F, VAL182F, VAL217F, VAL95G, VAL99G
• F-J: ALA121F, ALA124F, ALA16J, ALA177J, ALA190J, ALA193J, ALA216F, ALA216J, ARG102F, ARG139F, ARG153J, ARG17J, ARG185J, ARG188J, ARG210F, ARG210J, ARG215F, ARG215J, ARG218J, ASN138F, ASN208F, ASN221F, ASN91F, ASP103F, ASP176J, ASP189J, ASP96F, CYS110J, GLN142F, GLN151J, GLN156J, GLN157J, GLN207F, GLN207J, GLU111J, GLU152J, GLU20J, GLU212F, GLU212J, GLU97F, GLY119F, GLY119J, GLY133F, GLY186J, GLY18J, GLY200J, HIS112J, HIS113J, HIS179J, HIS211F, HIS211J, HIS219F, HIS220F, HIS220J, ILE104F, ILE117J, ILE126F, ILE132F, ILE137F, ILE140F, ILE160J, ILE175J, ILE187J, ILE89F, LEU106F, LEU134F, LEU154J, LEU159J, LEU199J, LEU19J, LEU214J, LEU88F, LYS120F, LYS120J, LYS136F, LYS183J, LYS204J, LYS92F, LYS94F, MET93F, MET98F, PHE203J, PHE213F, PHE213J, PRO127F, PRO22J, PRO84F, SER135F, SER181J, SER192J, SER198J, SER205J, SER206F, SER206J, THR100F, THR105F, THR122F, THR155J, THR191J, THR194J, THR195J, THR196J, THR197J, THR209F, THR87F, TYR125F, VAL101F, VAL123F, VAL131F, VAL141F, VAL150J, VAL173J, VAL178J, VAL182J, VAL217J, VAL95F, VAL99F
• F-L: ALA190F, ALA190L, ARG188F, ARG188L, ASP189F, ASP189L, ILE187F, ILE187L, LYS183F, LYS183L, THR191F, THR191L
• F-M: ALA145F, ALA145M, ALA184F, ALA184M, ALA190F, ALA190M, ALA40F, ALA40M, ALA55F, ALA55M, ALA67F, ALA67M, ARG147F, ARG147M, ARG153F, ARG153M, ARG185F, ARG185M, ARG188F, ARG188M, ARG24F, ARG24M, ARG35F, ARG35M, ARG65F, ARG65M, ASN32F, ASN51F, ASN51M, ASP118F, ASP118M, ASP189F, ASP189M, ASP31F, ASP53F, ASP53M, ASP56F, ASP56M, ASP57F, ASP57M, ASP72F, ASP72M, ASP79F, ASP79M, CYS110F, CYS110M, GLN142F, GLN142M, GLN146F, GLN146M, GLN149F, GLN149M, GLN48F, GLN48M, GLU111F, GLU111M, GLU29F, GLU29M, GLU45F, GLU45M, GLU61F, GLU61M, GLU73F, GLU73M, GLY119F, GLY119M, GLY186F, GLY186M, GLY41F, GLY41M, HIS112F, HIS112M, HIS113F, HIS113M, HIS179M, HIS220F, HIS220M, HIS28F, HIS28M, HIS42F, HIS42M, HIS64F, HIS64M, ILE117F, ILE117M, ILE187F, ILE39F, ILE39M, ILE46F, ILE46M, ILE66F, ILE66M, ILE74F, ILE74M, LEU106F, LEU106M, LEU23F, LEU23M, LEU38F, LEU38M, LEU49F, LEU49M, LEU50F, LEU50M, LEU52F, LEU52M, LEU54F, LEU54M, LEU59F, LEU59M, LEU78F, LEU78M, LYS120F, LYS120M, LYS183F, LYS183M, LYS36F, LYS36M, LYS68F, LYS68M, MET30F, MET30M, MET43F, MET43M, MET47F, MET47M, MET60F, MET60M, MET69F, MET69M, PHE114F, PHE114M, PHE75F, PHE75M, PRO148F, PRO148M, PRO22F, PRO22M, PRO25F, PRO25M, PRO26F, PRO26M, PRO63F, PRO63M, SER108F, SER108M, SER181F, SER181M, SER37F, SER37M, SER58F, SER58M, SER76F, SER76M, THR105F, THR105M, THR107F, THR107M, THR109F, THR109M, THR116F, THR116M, THR191F, THR21F, THR21M, THR34F, THR34M, THR44F, THR44M, THR62F, THR62M, TYR180F, TYR180M, TYR70F, TYR70M, VAL115F, VAL115M, VAL150F, VAL150M, VAL178F, VAL178M, VAL182M, VAL27F, VAL27M, VAL71F, VAL71M
• F-N: ALA55F, ALA55N, ARG139F, ARG139N, ARG65F, ARG65N, ASN221F, ASN221N, ASP56F, ASP56N, ASP57F, ASP57N, GLU61F, GLU61N, GLU73N, GLU90F, GLU90N, GLY133F, HIS220F, HIS220N, HIS64F, HIS64N, ILE89F, ILE89N, LEU59F, LEU59N, LEU88F, LEU88N, LYS120N, LYS136F, LYS136N, LYS68F, LYS68N, LYS85F, LYS85N, LYS92F, LYS92N, MET60F, MET60N, SER58F, SER58N, THR87F, THR87N
• F-O: ASN221F, ASN221O
• G-H: ALA121H, ALA124H, ALA16G, ALA177G, ALA190G, ALA193G, ALA216G, ALA216H, ARG102H, ARG139H, ARG153G, ARG17G, ARG185G, ARG188G, ARG210G, ARG210H, ARG215G, ARG215H, ARG218G, ASN138H, ASN208H, ASN221H, ASN91H, ASP103H, ASP176G, ASP189G, ASP96H, CYS110G, GLN142H, GLN151G, GLN156G, GLN157G, GLN207G, GLN207H, GLU111G, GLU152G, GLU20G, GLU212G, GLU212H, GLU97H, GLY119G, GLY133H, GLY186G, GLY18G, GLY200G, HIS112G, HIS113G, HIS179G, HIS211G, HIS211H, HIS219H, HIS220G, HIS220H, ILE104H, ILE117G, ILE126H, ILE132H, ILE137H, ILE140H, ILE160G, ILE175G, ILE187G, ILE89H, LEU106H, LEU134H, LEU154G, LEU159G, LEU199G, LEU19G, LEU214G, LEU88H, LYS120G, LYS120H, LYS136H, LYS183G, LYS204G, LYS92H, LYS94H, MET93H, MET98H, PHE143H, PHE203G, PHE213G, PHE213H, PRO127H, PRO22G, PRO84H, SER135H, SER181G, SER192G, SER198G, SER206H, THR100H, THR105H, THR122H, THR155G, THR191G, THR194G, THR195G, THR196G, THR197G, THR209H, THR21G, THR87H, TYR125H, VAL101H, VAL123H, VAL131H, VAL141H, VAL150G, VAL173G, VAL178G, VAL182G, VAL217G, VAL95H, VAL99H
• G-K: ALA190G, ALA190K, ARG188G, ARG188K, ASP189G, ASP189K, ILE187G, ILE187K, LYS183G, LYS183K, THR191G, THR191K
• G-L: ALA145G, ALA145L, ALA184G, ALA184L, ALA190G, ALA190L, ALA40G, ALA40L, ALA55G, ALA55L, ALA67G, ALA67L, ARG147G, ARG147L, ARG153G, ARG153L, ARG185G, ARG185L, ARG188G, ARG188L, ARG24G, ARG24L, ARG35G, ARG35L, ARG65G, ARG65L, ASN32L, ASN51G, ASN51L, ASP118G, ASP118L, ASP31G, ASP31L, ASP53G, ASP53L, ASP56G, ASP56L, ASP57G, ASP57L, ASP72G, ASP72L, ASP79G, ASP79L, CYS110G, CYS110L, GLN142G, GLN142L, GLN146G, GLN146L, GLN149G, GLN149L, GLN48G, GLN48L, GLU111G, GLU111L, GLU29G, GLU29L, GLU45G, GLU45L, GLU61G, GLU61L, GLU73G, GLU73L, GLY119G, GLY119L, GLY186G, GLY186L, GLY41G, GLY41L, HIS112G, HIS112L, HIS113G, HIS113L, HIS220G, HIS220L, HIS28G, HIS28L, HIS42G, HIS42L, HIS64G, HIS64L, ILE117G, ILE117L, ILE187L, ILE39G, ILE39L, ILE46G, ILE46L, ILE66G, ILE66L, ILE74G, ILE74L, LEU106G, LEU106L, LEU23G, LEU23L, LEU38G, LEU38L, LEU49G, LEU49L, LEU50G, LEU50L, LEU52G, LEU52L, LEU54G, LEU54L, LEU59G, LEU59L, LEU78G, LEU78L, LYS120G, LYS120L, LYS183G, LYS183L, LYS36G, LYS36L, LYS68G, LYS68L, MET30G, MET30L, MET43G, MET43L, MET47G, MET47L, MET60G, MET60L, MET69G, MET69L, PHE114G, PHE114L, PHE143L, PHE75G, PHE75L, PRO148G, PRO148L, PRO22G, PRO22L, PRO25G, PRO25L, PRO26G, PRO26L, PRO63G, PRO63L, SER108G, SER108L, SER181G, SER181L, SER37G, SER37L, SER58G, SER58L, SER76G, SER76L, THR105G, THR105L, THR107G, THR107L, THR109G, THR109L, THR116G, THR116L, THR191G, THR21G, THR21L, THR34G, THR34L, THR44G, THR44L, THR62G, THR62L, TYR180G, TYR180L, TYR70G, TYR70L, VAL115G, VAL115L, VAL150G, VAL150L, VAL178G, VAL178L, VAL182G, VAL182L, VAL27G, VAL27L, VAL71G, VAL71L
• G-M: ALA55G, ALA55M, ARG139G, ARG139M, ARG65G, ARG65M, ASN221G, ASN221M, ASN91G, ASN91M, ASP56G, ASP56M, ASP57G, ASP57M, GLU61G, GLU61M, GLU73G, GLU73M, GLU90G, GLU90M, GLY133G, HIS220G, HIS220M, HIS64G, HIS64M, ILE89G, ILE89M, LEU59G, LEU59M, LEU88G, LEU88M, LYS120M, LYS136G, LYS136M, LYS68G, LYS68M, LYS85G, LYS85M, LYS92G, LYS92M, MET60G, MET60M, SER58G, SER58M, THR87G, THR87M
• G-N: ASN221G, ASN221N
• H-I: ALA121I, ALA124I, ALA16H, ALA177H, ALA190H, ALA193H, ALA216H, ALA216I, ARG102I, ARG139I, ARG153H, ARG17H, ARG185H, ARG188H, ARG210H, ARG210I, ARG215H, ARG215I, ARG218H, ASN138I, ASN208I, ASN221I, ASN91I, ASP103I, ASP176H, ASP189H, ASP96I, CYS110H, GLN142I, GLN151H, GLN156H, GLN157H, GLN207H, GLN207I, GLU111H, GLU152H, GLU20H, GLU212H, GLU212I, GLU90I, GLU97I, GLY119I, GLY133I, GLY186H, GLY18H, GLY200H, HIS112H, HIS113H, HIS179H, HIS211H, HIS211I, HIS219H, HIS219I, HIS220H, HIS220I, ILE104I, ILE117H, ILE126I, ILE132I, ILE137I, ILE140I, ILE160H, ILE175H, ILE187H, ILE89I, LEU106I, LEU134I, LEU154H, LEU159H, LEU199H, LEU19H, LEU214H, LEU88I, LYS120H, LYS120I, LYS136I, LYS183H, LYS204H, LYS92I, LYS94I, MET93I, MET98I, PHE203H, PHE213H, PHE213I, PRO127I, PRO22H, PRO84I, SER135I, SER181H, SER192H, SER198H, SER206I, THR100I, THR105I, THR122I, THR155H, THR191H, THR194H, THR195H, THR196H, THR197H, THR209I, THR87I, TYR125I, VAL101I, VAL123I, VAL131I, VAL141I, VAL150H, VAL173H, VAL178H, VAL182H, VAL217H, VAL95I, VAL99I
• H-K: ALA145H, ALA145K, ALA184H, ALA184K, ALA190H, ALA190K, ALA40H, ALA40K, ALA55H, ALA55K, ALA67H, ALA67K, ARG147H, ARG147K, ARG153H, ARG153K, ARG185H, ARG185K, ARG188H, ARG188K, ARG24H, ARG24K, ARG35H, ARG35K, ARG65H, ARG65K, ASN51H, ASN51K, ASP118H, ASP118K, ASP31K, ASP53H, ASP53K, ASP56H, ASP56K, ASP57H, ASP57K, ASP72H, ASP72K, ASP79H, ASP79K, CYS110H, CYS110K, GLN142H, GLN142K, GLN146H, GLN146K, GLN149H, GLN149K, GLN48H, GLN48K, GLU111H, GLU111K, GLU29H, GLU29K, GLU45H, GLU45K, GLU61H, GLU61K, GLU73H, GLU73K, GLY119H, GLY119K, GLY186H, GLY186K, GLY41H, GLY41K, HIS112H, HIS112K, HIS113H, HIS113K, HIS179K, HIS220H, HIS220K, HIS28H, HIS28K, HIS42H, HIS42K, HIS64H, HIS64K, ILE117H, ILE117K, ILE187H, ILE39H, ILE39K, ILE46H, ILE46K, ILE66H, ILE66K, ILE74H, ILE74K, LEU106H, LEU106K, LEU23H, LEU23K, LEU38H, LEU38K, LEU49H, LEU49K, LEU50H, LEU50K, LEU52H, LEU52K, LEU54H, LEU54K, LEU59H, LEU59K, LEU78H, LEU78K, LYS120H, LYS120K, LYS183H, LYS183K, LYS36H, LYS36K, LYS68H, LYS68K, MET30H, MET30K, MET43H, MET43K, MET47H, MET47K, MET60H, MET60K, MET69H, MET69K, PHE114H, PHE114K, PHE143H, PHE75H, PHE75K, PRO148H, PRO148K, PRO22H, PRO22K, PRO25H, PRO25K, PRO26H, PRO26K, PRO63H, PRO63K, SER108H, SER108K, SER181H, SER181K, SER37H, SER37K, SER58H, SER58K, SER76H, SER76K, THR105H, THR105K, THR107H, THR107K, THR109H, THR109K, THR116H, THR116K, THR21H, THR21K, THR34H, THR34K, THR44H, THR44K, THR62H, THR62K, TYR180H, TYR180K, TYR70H, TYR70K, VAL115H, VAL115K, VAL150H, VAL150K, VAL178H, VAL178K, VAL182H, VAL27H, VAL27K, VAL71H, VAL71K
• H-L: ALA55H, ALA55L, ARG139H, ARG139L, ARG65H, ARG65L, ASN221H, ASN221L, ASP56H, ASP56L, ASP57H, ASP57L, GLU61H, GLU61L, GLU73L, GLU90H, GLU90L, GLY133H, GLY133L, HIS220H, HIS220L, HIS64H, HIS64L, ILE89H, ILE89L, LEU59H, LEU59L, LEU88H, LEU88L, LYS120H, LYS120L, LYS136H, LYS136L, LYS68H, LYS68L, LYS85H, LYS85L, LYS92H, LYS92L, MET60H, MET60L, SER58H, SER58L, THR62L, THR87H, THR87L
• H-M: ASN221H, ASN221M
• H-O: ALA190H, ALA190O, ARG188H, ARG188O, ASP189H, ASP189O, ILE187H, ILE187O, LYS183H, LYS183O, THR191H, THR191O
• I-J: ALA121J, ALA124J, ALA16I, ALA177I, ALA190I, ALA193I, ALA216I, ALA216J, ARG102J, ARG139J, ARG153I, ARG17I, ARG185I, ARG188I, ARG210I, ARG210J, ARG215I, ARG215J, ARG218I, ASN138J, ASN208J, ASN221J, ASN91J, ASP103J, ASP176I, ASP189I, ASP96J, CYS110I, GLN142J, GLN151I, GLN156I, GLN157I, GLN207I, GLN207J, GLU111I, GLU152I, GLU20I, GLU212I, GLU212J, GLU97J, GLY119I, GLY133J, GLY186I, GLY18I, GLY200I, HIS112I, HIS113I, HIS179I, HIS211I, HIS211J, HIS219I, HIS219J, HIS220I, HIS220J, ILE104J, ILE117I, ILE126J, ILE132J, ILE137J, ILE140J, ILE160I, ILE175I, ILE187I, ILE89J, LEU106J, LEU134J, LEU154I, LEU159I, LEU199I, LEU19I, LEU214I, LEU88J, LYS120I, LYS120J, LYS136J, LYS183I, LYS204I, LYS92J, LYS94J, MET93J, MET98J, PHE203I, PHE213I, PHE213J, PRO127J, PRO22I, PRO84J, SER135J, SER181I, SER192I, SER198I, SER206J, THR100J, THR105J, THR122J, THR155I, THR191I, THR194I, THR195I, THR196I, THR197I, THR209J, THR87J, TYR125J, VAL101J, VAL123J, VAL131J, VAL141J, VAL150I, VAL173I, VAL178I, VAL182I, VAL217I, VAL95J, VAL99J
• I-K: ALA55I, ALA55K, ARG139I, ARG139K, ARG65I, ARG65K, ASN221I, ASN221K, ASP56I, ASP56K, ASP57I, ASP57K, GLU61I, GLU61K, GLU73K, GLU90I, GLU90K, GLY133K, HIS220I, HIS220K, HIS64I, HIS64K, ILE89I, ILE89K, LEU59I, LEU59K, LEU88I, LEU88K, LYS136I, LYS136K, LYS68I, LYS68K, LYS85I, LYS85K, LYS92I, LYS92K, SER58I, SER58K, THR87I, THR87K
• I-L: ASN221I, ASN221L
• I-N: ALA190I, ALA190N, ARG188I, ARG188N, ASP189I, ASP189N, ILE187I, ILE187N, LYS183N, THR191I, THR191N
• I-O: ALA145I, ALA145O, ALA184I, ALA184O, ALA190I, ALA190O, ALA40I, ALA40O, ALA55I, ALA55O, ALA67I, ALA67O, ARG147I, ARG147O, ARG153I, ARG153O, ARG185I, ARG185O, ARG188I, ARG188O, ARG24I, ARG24O, ARG35I, ARG35O, ARG65I, ARG65O, ASN32O, ASN51I, ASN51O, ASP118I, ASP118O, ASP31O, ASP53I, ASP53O, ASP56I, ASP56O, ASP57I, ASP57O, ASP72I, ASP72O, ASP79I, ASP79O, CYS110I, CYS110O, GLN142I, GLN142O, GLN146I, GLN146O, GLN149I, GLN149O, GLN48I, GLN48O, GLU111I, GLU111O, GLU29I, GLU29O, GLU45I, GLU45O, GLU61I, GLU61O, GLU73I, GLU73O, GLY119I, GLY119O, GLY186I, GLY186O, GLY41I, GLY41O, HIS112I, HIS112O, HIS113I, HIS113O, HIS179O, HIS220I, HIS220O, HIS28I, HIS28O, HIS42I, HIS42O, HIS64I, HIS64O, ILE117I, ILE117O, ILE187I, ILE39I, ILE39O, ILE46I, ILE46O, ILE66I, ILE66O, ILE74I, ILE74O, LEU106I, LEU106O, LEU23I, LEU23O, LEU38I, LEU38O, LEU49I, LEU49O, LEU50I, LEU50O, LEU52I, LEU52O, LEU54I, LEU54O, LEU59I, LEU59O, LEU78I, LEU78O, LYS120I, LYS120O, LYS183I, LYS183O, LYS36I, LYS36O, LYS68I, LYS68O, MET30I, MET30O, MET43I, MET43O, MET47I, MET47O, MET60I, MET60O, MET69I, MET69O, PHE114I, PHE114O, PHE143I, PHE75I, PHE75O, PRO148I, PRO148O, PRO22I, PRO22O, PRO25I, PRO25O, PRO26I, PRO26O, PRO63I, PRO63O, SER108I, SER108O, SER181I, SER181O, SER37I, SER37O, SER58I, SER58O, SER76I, SER76O, THR105I, THR105O, THR107I, THR107O, THR109I, THR109O, THR116I, THR116O, THR191O, THR21I, THR21O, THR34I, THR34O, THR44I, THR44O, THR62I, THR62O, TYR180I, TYR180O, TYR70I, TYR70O, VAL115I, VAL115O, VAL150I, VAL150O, VAL178I, VAL178O, VAL182I, VAL27I, VAL27O, VAL71I, VAL71O
• J-K: ASN221J, ASN221K
• J-M: ALA190J, ALA190M, ARG188J, ARG188M, ASP189J, ASP189M, ILE187J, ILE187M, LYS183J, LYS183M, THR191J, THR191M
• J-N: ALA145J, ALA145N, ALA184J, ALA184N, ALA190J, ALA190N, ALA40J, ALA40N, ALA55J, ALA55N, ALA67J, ALA67N, ARG147J, ARG147N, ARG153J, ARG153N, ARG185J, ARG185N, ARG188J, ARG188N, ARG24J, ARG24N, ARG35J, ARG35N, ARG65J, ARG65N, ASN51J, ASN51N, ASP118J, ASP118N, ASP31J, ASP31N, ASP53J, ASP53N, ASP56J, ASP56N, ASP57J, ASP57N, ASP72J, ASP72N, ASP79J, ASP79N, CYS110J, CYS110N, GLN142J, GLN142N, GLN146J, GLN146N, GLN149J, GLN149N, GLN48J, GLN48N, GLU111J, GLU111N, GLU29J, GLU29N, GLU45J, GLU45N, GLU61J, GLU61N, GLU73J, GLU73N, GLY119J, GLY119N, GLY186J, GLY186N, GLY41J, GLY41N, HIS112J, HIS112N, HIS113J, HIS113N, HIS179J, HIS179N, HIS220J, HIS220N, HIS28J, HIS28N, HIS42J, HIS42N, HIS64J, HIS64N, ILE117J, ILE117N, ILE187J, ILE187N, ILE39J, ILE39N, ILE46J, ILE46N, ILE66J, ILE66N, ILE74J, ILE74N, LEU106J, LEU106N, LEU23J, LEU23N, LEU38J, LEU38N, LEU49J, LEU49N, LEU50J, LEU50N, LEU52J, LEU52N, LEU54J, LEU54N, LEU59J, LEU59N, LEU78J, LEU78N, LYS120J, LYS120N, LYS183J, LYS183N, LYS36J, LYS36N, LYS68J, LYS68N, MET30J, MET30N, MET43J, MET43N, MET47J, MET47N, MET60J, MET60N, MET69J, MET69N, PHE114J, PHE114N, PHE75J, PHE75N, PRO148J, PRO148N, PRO22J, PRO22N, PRO25J, PRO25N, PRO26J, PRO26N, PRO63J, PRO63N, SER108J, SER108N, SER181J, SER181N, SER37J, SER37N, SER58J, SER58N, SER76J, SER76N, THR105J, THR105N, THR107J, THR107N, THR109J, THR109N, THR116J, THR116N, THR21J, THR21N, THR34J, THR34N, THR44J, THR44N, THR62J, THR62N, TYR180J, TYR180N, TYR70J, TYR70N, VAL115J, VAL115N, VAL150J, VAL150N, VAL178J, VAL178N, VAL27J, VAL27N, VAL71J, VAL71N
• J-O: ALA55J, ALA55O, ARG139J, ARG139O, ARG65J, ARG65O, ASN221J, ASN221O, ASN91O, ASP56J, ASP56O, ASP57J, ASP57O, GLU61J, GLU61O, GLU73J, GLU73O, GLU90J, GLU90O, GLY133J, HIS220J, HIS220O, HIS64J, HIS64O, ILE89J, ILE89O, LEU59J, LEU59O, LEU88J, LEU88O, LYS136J, LYS136O, LYS68J, LYS68O, LYS85J, LYS85O, LYS92J, LYS92O, MET60J, SER58J, SER58O, THR62J, THR87J, THR87O
• K-L: ALA121L, ALA124L, ALA16K, ALA177K, ALA190K, ALA193K, ALA216K, ALA216L, ARG102L, ARG139L, ARG153K, ARG17K, ARG185K, ARG188K, ARG210K, ARG210L, ARG215K, ARG215L, ARG218K, ASN138L, ASN208L, ASN221L, ASN91L, ASP103L, ASP176K, ASP189K, ASP96L, CYS110K, GLN142L, GLN151K, GLN156K, GLN157K, GLN207K, GLN207L, GLU111K, GLU152K, GLU20K, GLU212K, GLU212L, GLU97L, GLY119K, GLY119L, GLY133L, GLY186K, GLY18K, GLY200K, HIS112K, HIS113K, HIS179K, HIS211K, HIS211L, HIS219K, HIS219L, HIS220K, HIS220L, ILE104L, ILE117K, ILE126L, ILE132L, ILE137L, ILE140L, ILE160K, ILE175K, ILE187K, ILE89L, LEU106L, LEU134L, LEU154K, LEU159K, LEU199K, LEU19K, LEU202L, LEU214K, LEU88L, LYS120K, LYS120L, LYS136L, LYS183K, LYS204K, LYS92L, LYS94L, MET93L, MET98L, PHE203K, PHE213K, PHE213L, PRO127L, PRO22K, PRO84L, SER135L, SER181K, SER192K, SER198K, SER205K, SER206K, SER206L, THR100L, THR105L, THR122L, THR155K, THR191K, THR194K, THR195K, THR196K, THR197K, THR209L, THR87L, TYR125L, VAL101L, VAL123L, VAL131L, VAL141L, VAL150K, VAL173K, VAL178K, VAL182K, VAL217K, VAL95L, VAL99L
• K-O: ALA121K, ALA124K, ALA16O, ALA177O, ALA190O, ALA193O, ALA216K, ALA216O, ARG102K, ARG139K, ARG153O, ARG17O, ARG185O, ARG188O, ARG210K, ARG210O, ARG215K, ARG215O, ARG218O, ASN138K, ASN208K, ASN221K, ASN91K, ASP103K, ASP176O, ASP189O, ASP96K, CYS110O, GLN142K, GLN151O, GLN156O, GLN157O, GLN207K, GLN207O, GLU111O, GLU152O, GLU20O, GLU212K, GLU212O, GLU97K, GLY119K, GLY133K, GLY186O, GLY18O, GLY200O, HIS112O, HIS113O, HIS179O, HIS211K, HIS211O, HIS219K, HIS220K, HIS220O, ILE104K, ILE117O, ILE126K, ILE132K, ILE137K, ILE140K, ILE160O, ILE175O, ILE187O, ILE89K, LEU106K, LEU134K, LEU154O, LEU159O, LEU199O, LEU19O, LEU214O, LEU88K, LYS120K, LYS120O, LYS136K, LYS183O, LYS204O, LYS92K, LYS94K, MET93K, MET98K, PHE143K, PHE203O, PHE213K, PHE213O, PRO127K, PRO22O, PRO84K, SER135K, SER181O, SER192O, SER198O, SER205O, SER206K, SER206O, THR100K, THR105K, THR122K, THR155O, THR191O, THR194O, THR195O, THR196O, THR197O, THR209K, THR87K, TYR125K, VAL101K, VAL123K, VAL131K, VAL141K, VAL150O, VAL173O, VAL178O, VAL182O, VAL217O, VAL95K, VAL99K
• L-M: ALA121M, ALA124M, ALA16L, ALA177L, ALA190L, ALA193L, ALA216L, ALA216M, ARG102M, ARG139M, ARG153L, ARG17L, ARG185L, ARG188L, ARG210L, ARG210M, ARG215L, ARG215M, ARG218L, ASN138M, ASN208M, ASN221M, ASN91M, ASP103M, ASP176L, ASP189L, ASP96M, CYS110L, GLN142M, GLN151L, GLN156L, GLN157L, GLN207L, GLN207M, GLU111L, GLU152L, GLU20L, GLU212L, GLU212M, GLU90M, GLU97M, GLY119M, GLY133M, GLY186L, GLY18L, GLY200L, HIS112L, HIS113L, HIS179L, HIS211L, HIS211M, HIS219M, HIS220L, HIS220M, ILE104M, ILE117L, ILE126M, ILE132M, ILE137M, ILE140M, ILE160L, ILE175L, ILE187L, ILE89M, LEU106M, LEU134M, LEU154L, LEU159L, LEU199L, LEU19L, LEU214L, LEU88M, LYS120L, LYS120M, LYS136M, LYS183L, LYS204L, LYS92M, LYS94M, MET93M, MET98M, PHE143M, PHE203L, PHE213L, PHE213M, PRO127M, PRO22L, PRO84M, SER135M, SER181L, SER192L, SER198L, SER206M, THR100M, THR105M, THR122M, THR155L, THR191L, THR194L, THR195L, THR196L, THR197L, THR209M, THR87M, TYR125M, VAL101M, VAL123M, VAL131M, VAL141M, VAL150L, VAL173L, VAL178L, VAL182L, VAL217L, VAL95M, VAL99M
• M-N: ALA121N, ALA124N, ALA16M, ALA177M, ALA190M, ALA193M, ALA216M, ALA216N, ARG102N, ARG139N, ARG153M, ARG17M, ARG185M, ARG188M, ARG210M, ARG210N, ARG215M, ARG215N, ARG218M, ASN138N, ASN208N, ASN221N, ASN91N, ASP103N, ASP176M, ASP189M, ASP96N, CYS110M, GLN142N, GLN151M, GLN156M, GLN157M, GLN207M, GLN207N, GLU111M, GLU152M, GLU20M, GLU212M, GLU212N, GLU97N, GLY119N, GLY133N, GLY186M, GLY18M, GLY200M, HIS112M, HIS113M, HIS179M, HIS211M, HIS211N, HIS219N, HIS220M, HIS220N, ILE104N, ILE117M, ILE126N, ILE132N, ILE137N, ILE140N, ILE160M, ILE175M, ILE187M, ILE89N, LEU106N, LEU134N, LEU154M, LEU159M, LEU199M, LEU19M, LEU202N, LEU214M, LEU88N, LYS120M, LYS120N, LYS136N, LYS183M, LYS204M, LYS92N, LYS94N, MET93N, MET98N, PHE203M, PHE213M, PHE213N, PRO127N, PRO22M, PRO84N, SER135N, SER181M, SER192M, SER198M, SER205M, SER206N, THR100N, THR105N, THR122N, THR155M, THR191M, THR194M, THR195M, THR196M, THR197M, THR209N, THR21M, THR87N, TYR125N, VAL101N, VAL123N, VAL131N, VAL141N, VAL150M, VAL173M, VAL178M, VAL182M, VAL217M, VAL95N, VAL99N
• N-O: ALA121O, ALA124O, ALA16N, ALA177N, ALA190N, ALA193N, ALA216N, ALA216O, ARG102O, ARG139O, ARG153N, ARG17N, ARG185N, ARG188N, ARG210N, ARG210O, ARG215N, ARG215O, ARG218N, ASN138O, ASN208O, ASN221O, ASN91O, ASP103O, ASP176N, ASP189N, ASP96O, CYS110N, GLN142O, GLN151N, GLN156N, GLN157N, GLN207N, GLN207O, GLU111N, GLU152N, GLU20N, GLU212N, GLU212O, GLU97O, GLY119O, GLY133O, GLY186N, GLY18N, GLY200N, HIS112N, HIS113N, HIS179N, HIS211N, HIS211O, HIS219O, HIS220N, HIS220O, ILE104O, ILE117N, ILE126O, ILE132O, ILE137O, ILE140O, ILE160N, ILE175N, ILE187N, ILE89O, LEU106O, LEU134O, LEU154N, LEU159N, LEU199N, LEU19N, LEU202O, LEU214N, LEU88O, LYS120O, LYS136O, LYS183N, LYS204N, LYS92O, LYS94O, MET93O, MET98O, PHE203N, PHE213N, PHE213O, PRO127O, PRO22N, PRO84O, SER135O, SER181N, SER192N, SER198N, SER206N, SER206O, THR100O, THR105O, THR122O, THR155N, THR191N, THR194N, THR195N, THR196N, THR197N, THR209O, THR87O, TYR125O, VAL101O, VAL123O, VAL131O, VAL141O, VAL150N, VAL173N, VAL178N, VAL182N, VAL217N, VAL95O, VAL99O
• A-B: ALA121B, ALA124B, ALA16A, ALA177A, ALA190A, ALA193A, ALA216A, ALA216B, ARG102B, ARG139B, ARG153A, ARG17A, ARG185A, ARG188A, ARG210A, ARG210B, ARG215A, ARG215B, ARG218A, ASN138B, ASN208B, ASN221B, ASN91B, ASP103B, ASP176A, ASP189A, ASP96B, CYS110A, GLN142B, GLN151A, GLN156A, GLN157A, GLN207A, GLN207B, GLU111A, GLU152A, GLU20A, GLU212A, GLU212B, GLU90B, GLU97B, GLY119B, GLY133B, GLY186A, GLY18A, GLY200A, HIS112A, HIS113A, HIS179A, HIS211A, HIS211B, HIS219B, HIS220A, HIS220B, ILE104B, ILE117A, ILE126B, ILE132B, ILE137B, ILE140B, ILE160A, ILE187A, ILE89B, LEU106B, LEU134B, LEU154A, LEU159A, LEU199A, LEU19A, LEU202B, LEU214A, LEU88B, LYS120A, LYS120B, LYS136B, LYS183A, LYS204A, LYS92B, LYS94B, MET93B, MET98B, PHE143B, PHE203A, PHE213A, PHE213B, PRO127B, PRO22A, PRO84B, SER135B, SER181A, SER192A, SER198A, SER205A, SER206B, THR100B, THR105B, THR122B, THR155A, THR191A, THR194A, THR195A, THR196A, THR197A, THR209B, THR87B, TYR125B, VAL101B, VAL123B, VAL131B, VAL141B, VAL150A, VAL173A, VAL178A, VAL182A, VAL217A, VAL95B, VAL99B
• A-E: ALA121A, ALA124A, ALA16E, ALA177E, ALA190E, ALA193E, ALA216A, ALA216E, ARG102A, ARG139A, ARG153E, ARG17E, ARG185E, ARG188E, ARG210A, ARG210E, ARG215A, ARG215E, ARG218E, ASN138A, ASN208A, ASN221A, ASN91A, ASP103A, ASP176E, ASP189E, ASP96A, CYS110E, GLN142A, GLN151E, GLN156E, GLN157E, GLN207A, GLN207E, GLU111E, GLU152E, GLU20E, GLU212A, GLU212E, GLU90A, GLU97A, GLY119A, GLY133A, GLY186E, GLY18E, GLY200E, HIS112E, HIS113E, HIS179E, HIS211A, HIS211E, HIS219A, HIS220A, HIS220E, ILE104A, ILE117E, ILE126A, ILE132A, ILE137A, ILE140A, ILE160E, ILE175E, ILE187E, ILE89A, LEU106A, LEU134A, LEU154E, LEU159E, LEU199E, LEU19E, LEU214E, LEU88A, LYS120A, LYS120E, LYS136A, LYS183E, LYS204E, LYS92A, LYS94A, MET93A, MET98A, PHE143A, PHE203E, PHE213A, PHE213E, PRO127A, PRO22E, PRO84A, SER135A, SER181E, SER192E, SER198E, SER205E, SER206A, SER206E, THR100A, THR105A, THR122A, THR155E, THR191E, THR194E, THR195E, THR196E, THR197E, THR209A, THR87A, TYR125A, VAL101A, VAL123A, VAL131A, VAL141A, VAL150E, VAL173E, VAL178E, VAL182E, VAL217E, VAL95A, VAL99A
• B-C: ALA121C, ALA124C, ALA16B, ALA177B, ALA190B, ALA193B, ALA216B, ALA216C, ARG102C, ARG139C, ARG153B, ARG17B, ARG185B, ARG188B, ARG210B, ARG210C, ARG215B, ARG215C, ARG218B, ASN138C, ASN208C, ASN221C, ASN91C, ASP103C, ASP176B, ASP189B, ASP96C, CYS110B, GLN142C, GLN151B, GLN156B, GLN157B, GLN207B, GLN207C, GLU111B, GLU152B, GLU20B, GLU212B, GLU212C, GLU97C, GLY119B, GLY119C, GLY133C, GLY186B, GLY18B, GLY200B, HIS112B, HIS113B, HIS179B, HIS211B, HIS211C, HIS219C, HIS220B, HIS220C, ILE104C, ILE117B, ILE126C, ILE132C, ILE137C, ILE140C, ILE160B, ILE175B, ILE187B, ILE89C, LEU106C, LEU134C, LEU154B, LEU159B, LEU199B, LEU19B, LEU202C, LEU214B, LYS120B, LYS120C, LYS136C, LYS183B, LYS204B, LYS92C, LYS94C, MET93C, MET98C, PHE203B, PHE213B, PHE213C, PRO127C, PRO22B, PRO84C, SER135C, SER181B, SER192B, SER198B, SER205B, SER206B, SER206C, THR100C, THR105C, THR122C, THR155B, THR191B, THR194B, THR195B, THR196B, THR197B, THR209C, THR87C, TYR125C, VAL101C, VAL123C, VAL131C, VAL141C, VAL150B, VAL173B, VAL178B, VAL182B, VAL217B, VAL95C, VAL99C
• C-D: ALA121D, ALA124D, ALA16C, ALA177C, ALA190C, ALA193C, ALA216C, ALA216D, ARG102D, ARG139D, ARG153C, ARG17C, ARG185C, ARG188C, ARG210C, ARG210D, ARG215C, ARG215D, ARG218C, ASN138D, ASN208D, ASN221D, ASN91D, ASP103D, ASP176C, ASP189C, ASP96D, CYS110C, GLN142D, GLN151C, GLN156C, GLN157C, GLN207C, GLN207D, GLU111C, GLU152C, GLU20C, GLU212C, GLU212D, GLU90D, GLU97D, GLY119C, GLY119D, GLY133D, GLY186C, GLY18C, GLY200C, HIS112C, HIS113C, HIS179C, HIS211C, HIS211D, HIS219D, HIS220C, HIS220D, ILE104D, ILE117C, ILE126D, ILE132D, ILE137D, ILE140D, ILE160C, ILE175C, ILE187C, ILE89D, LEU106D, LEU134D, LEU154C, LEU159C, LEU199C, LEU19C, LEU214C, LEU88D, LYS120D, LYS136D, LYS183C, LYS204C, LYS92D, LYS94D, MET93D, MET98D, PHE143D, PHE203C, PHE213C, PHE213D, PRO127D, PRO22C, PRO84D, SER135D, SER181C, SER192C, SER198C, SER206D, THR100D, THR105D, THR122D, THR155C, THR191C, THR194C, THR195C, THR196C, THR197C, THR209D, THR21C, THR87D, TYR125D, VAL101D, VAL123D, VAL131D, VAL141D, VAL150C, VAL173C, VAL178C, VAL182C, VAL217C, VAL95D, VAL99D
• D-E: ALA121E, ALA16D, ALA177D, ALA190D, ALA193D, ALA216D, ALA216E, ARG102E, ARG139E, ARG153D, ARG17D, ARG185D, ARG188D, ARG210D, ARG210E, ARG215D, ARG215E, ARG218D, ASN138E, ASN208E, ASN221E, ASN91E, ASP103E, ASP176D, ASP189D, ASP96E, CYS110D, GLN142E, GLN151D, GLN156D, GLN157D, GLN207D, GLN207E, GLU111D, GLU152D, GLU20D, GLU212D, GLU212E, GLU90E, GLU97E, GLY119E, GLY133E, GLY186D, GLY18D, GLY200D, HIS112D, HIS113D, HIS179D, HIS211D, HIS211E, HIS219E, HIS220D, HIS220E, ILE104E, ILE117D, ILE126E, ILE132E, ILE137E, ILE140E, ILE160D, ILE175D, ILE187D, ILE89E, LEU106E, LEU134E, LEU154D, LEU159D, LEU199D, LEU19D, LEU202E, LEU214D, LEU88E, LYS120E, LYS136E, LYS183D, LYS204D, LYS92E, LYS94E, MET93E, MET98E, PHE143E, PHE203D, PHE213D, PHE213E, PRO127E, PRO22D, PRO84E, SER135E, SER181D, SER192D, SER198D, SER205D, SER206D, SER206E, THR100E, THR105E, THR122E, THR155D, THR191D, THR194D, THR195D, THR196D, THR197D, THR209E, THR87E, TYR125E, VAL101E, VAL123E, VAL131E, VAL141E, VAL150D, VAL173D, VAL178D, VAL182D, VAL217D, VAL95E, VAL99E