1N3R

biosynthesis of pteridins. reaction mechanism of gtp cyclohydrolase i

• Total interactions analyzed: 105
• Total true interactions: 16
• Strongest Interaction:
  • Chains: M-N
  • Int. Res.: 120
  • Norm. En. per Res.: -4.0187
• Hub Node: F(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-94.9532	-26.9816	-301.529	-423.4638	122	29	1	13093	8	43	58
A-E	-93.8279	-30.7621	-296.019	-420.609	122	18	1	12193	8	41	53
B-C	-106.0958	-58.4561	-307.49	-472.0419	118	22	1	12518	11	40	56
C-D	-104.6507	-38.0268	-271.456	-414.1336	121	25	1	12467	10	40	57
D-E	-113.3548	-47.0214	-286.085	-446.4613	119	20	1	12383	8	40	55
F-G	-128.8476	-40.5306	-299.618	-468.9962	119	27	1	12739	9	42	54
F-J	-121.7878	-59.6485	-258.151	-439.5873	117	26	1	12144	10	41	57
F-N	0.0	10.8579	-10.312	0.5459	24	1	0	576	0	7	7
G-H	-101.0707	-47.2883	-276.678	-425.037	116	22	1	12046	9	40	53
H-I	-110.8364	-42.6313	-296.274	-449.7417	120	20	1	12405	7	42	55
I-J	-111.5887	-56.8522	-280.628	-449.0688	117	24	1	12274	8	40	56
K-L	-95.5987	-54.0777	-293.638	-443.3144	121	23	1	12560	9	43	57
K-O	-98.8196	-47.2337	-290.601	-436.6544	120	22	1	12278	10	41	54
L-M	-114.3333	-49.0303	-287.716	-451.0796	119	20	1	12447	8	41	56
M-N	-122.7323	-52.8173	-306.69	-482.2396	120	26	1	12855	10	41	58
N-O	-101.5103	-54.6298	-302.871	-459.0111	124	24	1	12651	10	40	54

Interface residues

• A-B: ALA121B, ALA124B, ALA16A, ALA177A, ALA190A, ALA193A, ALA216A, ALA216B, ARG102B, ARG139B, ARG153A, ARG17A, ARG185A, ARG188A, ARG210A, ARG210B, ARG215A, ARG215B, ARG218A, ARG218B, ASN138B, ASN208B, ASN221A, ASN221B, ASN91B, ASP103B, ASP176A, ASP189A, ASP96B, CYS110A, CYS181A, GLN142B, GLN146B, GLN151A, GLN156A, GLN157A, GLN207A, GLN207B, GLU111A, GLU152A, GLU20A, GLU212A, GLU212B, GLU90B, GLU97B, GLY119A, GLY119B, GLY133B, GLY186A, GLY18A, GLY200A, HIS113A, HIS179A, HIS211A, HIS211B, HIS219A, HIS219B, HIS220A, HIS220B, ILE104B, ILE117A, ILE126B, ILE132B, ILE137B, ILE140B, ILE160A, ILE175A, ILE187A, ILE89B, LEU106B, LEU134B, LEU154A, LEU159A, LEU199A, LEU19A, LEU202B, LEU214A, LYS120A, LYS120B, LYS136B, LYS183A, LYS204A, LYS92B, LYS94B, MET93B, MET98B, PHE143B, PHE203A, PHE213A, PHE213B, PRO127B, PRO22A, PRO84B, SER112A, SER135B, SER192A, SER198A, SER206B, THR100B, THR105B, THR107B, THR122B, THR155A, THR191A, THR194A, THR195A, THR196A, THR197A, THR209B, THR87B, TYR125B, VAL101B, VAL123B, VAL131B, VAL141B, VAL150A, VAL173A, VAL178A, VAL182A, VAL217A, VAL95B, VAL99B
• A-E: ALA121A, ALA124A, ALA16E, ALA177E, ALA190E, ALA193E, ALA216A, ALA216E, ARG102A, ARG139A, ARG153E, ARG17E, ARG185E, ARG188E, ARG210A, ARG210E, ARG215A, ARG215E, ARG218A, ARG218E, ASN138A, ASN208A, ASN221A, ASN91A, ASP103A, ASP176E, ASP189E, ASP96A, CYS110E, CYS181E, GLN142A, GLN146A, GLN149E, GLN151E, GLN156E, GLN157E, GLN207A, GLN207E, GLU111E, GLU152E, GLU20E, GLU212A, GLU212E, GLU90A, GLU97A, GLY119A, GLY133A, GLY186E, GLY18E, GLY200E, HIS113E, HIS179E, HIS211A, HIS211E, HIS219A, HIS219E, HIS220A, HIS220E, ILE104A, ILE117E, ILE126A, ILE132A, ILE137A, ILE140A, ILE160E, ILE175E, ILE187E, ILE89A, LEU106A, LEU134A, LEU154E, LEU159E, LEU199E, LEU19E, LEU202A, LEU214E, LYS120A, LYS120E, LYS136A, LYS183E, LYS204E, LYS92A, LYS94A, MET93A, MET98A, PHE143A, PHE203E, PHE213A, PHE213E, PRO127A, PRO22E, PRO84A, SER112E, SER135A, SER192E, SER198E, SER205E, SER206A, SER206E, THR100A, THR105A, THR122A, THR155E, THR191E, THR194E, THR195E, THR196E, THR197E, THR209A, THR87A, TYR125A, VAL101A, VAL123A, VAL131A, VAL141A, VAL150E, VAL173E, VAL178E, VAL182E, VAL217E, VAL95A, VAL99A
• B-C: ALA121C, ALA124C, ALA16B, ALA177B, ALA190B, ALA193B, ALA216B, ALA216C, ARG102C, ARG139C, ARG153B, ARG17B, ARG185B, ARG188B, ARG210B, ARG210C, ARG215B, ARG215C, ARG218B, ASN138C, ASN208C, ASN221C, ASN91C, ASP103C, ASP176B, ASP189B, ASP96C, CYS110B, CYS181B, GLN142C, GLN151B, GLN156B, GLN157B, GLN207B, GLN207C, GLU111B, GLU152B, GLU20B, GLU212B, GLU212C, GLU90C, GLU97C, GLY119C, GLY133C, GLY186B, GLY18B, GLY200B, HIS113B, HIS179B, HIS211B, HIS211C, HIS219B, HIS219C, HIS220B, HIS220C, ILE104C, ILE117B, ILE126C, ILE132C, ILE137C, ILE140C, ILE160B, ILE175B, ILE187B, ILE89C, LEU106C, LEU134C, LEU154B, LEU159B, LEU199B, LEU19B, LEU202C, LEU214B, LYS120B, LYS120C, LYS136C, LYS183B, LYS204B, LYS92C, LYS94C, MET93C, MET98C, PHE143C, PHE203B, PHE213B, PHE213C, PRO127C, PRO22B, PRO84C, SER112B, SER130C, SER135C, SER192B, SER198B, SER206C, THR100C, THR105C, THR122C, THR155B, THR191B, THR194B, THR195B, THR196B, THR197B, THR209C, THR87C, TYR125C, VAL101C, VAL123C, VAL131C, VAL141C, VAL150B, VAL173B, VAL178B, VAL182B, VAL217B, VAL95C, VAL99C
• C-D: ALA121D, ALA124D, ALA16C, ALA177C, ALA190C, ALA193C, ALA216C, ALA216D, ARG102D, ARG139D, ARG153C, ARG17C, ARG185C, ARG188C, ARG210C, ARG210D, ARG215C, ARG215D, ARG218C, ASN138D, ASN208C, ASN208D, ASN221D, ASN91D, ASP103D, ASP176C, ASP189C, ASP96D, CYS110C, CYS181C, GLN142D, GLN146D, GLN151C, GLN156C, GLN157C, GLN207C, GLN207D, GLU111C, GLU152C, GLU20C, GLU212C, GLU212D, GLU90D, GLU97D, GLY119C, GLY119D, GLY133D, GLY186C, GLY18C, GLY200C, HIS113C, HIS179C, HIS211C, HIS211D, HIS219C, HIS219D, HIS220C, HIS220D, ILE104D, ILE117C, ILE126D, ILE132D, ILE137D, ILE140D, ILE175C, ILE187C, ILE89D, LEU106D, LEU134D, LEU154C, LEU159C, LEU199C, LEU19C, LEU202D, LEU214C, LYS120C, LYS120D, LYS136D, LYS183C, LYS204C, LYS92D, LYS94D, MET93D, MET98D, PHE143D, PHE203C, PHE213C, PHE213D, PRO127D, PRO22C, PRO84D, SER112C, SER135D, SER192C, SER198C, SER205C, SER206C, SER206D, THR100D, THR105D, THR122D, THR155C, THR191C, THR194C, THR195C, THR196C, THR197C, THR209D, THR87D, TYR125D, VAL101D, VAL123D, VAL131D, VAL141D, VAL150C, VAL173C, VAL178C, VAL182C, VAL217C, VAL95D, VAL99D
• D-E: ALA121E, ALA124E, ALA16D, ALA177D, ALA190D, ALA193D, ALA216D, ALA216E, ARG102E, ARG139E, ARG153D, ARG17D, ARG185D, ARG188D, ARG210D, ARG210E, ARG215D, ARG215E, ARG218D, ASN138E, ASN208E, ASN91E, ASP103E, ASP176D, ASP189D, ASP96E, CYS110D, CYS181D, GLN142E, GLN146E, GLN151D, GLN156D, GLN157D, GLN207D, GLN207E, GLU111D, GLU152D, GLU20D, GLU212D, GLU212E, GLU90E, GLU97E, GLY119D, GLY119E, GLY133E, GLY186D, GLY18D, GLY200D, HIS113D, HIS179D, HIS211D, HIS211E, HIS219E, HIS220D, HIS220E, ILE104E, ILE117D, ILE126E, ILE132E, ILE137E, ILE140E, ILE160D, ILE175D, ILE187D, ILE89E, LEU106E, LEU134E, LEU154D, LEU159D, LEU199D, LEU19D, LEU202E, LEU214D, LYS120D, LYS120E, LYS136E, LYS183D, LYS204D, LYS92E, LYS94E, MET93E, MET98E, PHE143E, PHE203D, PHE213D, PHE213E, PRO127E, PRO22D, PRO84E, SER112D, SER135E, SER192D, SER198D, SER205D, SER206D, SER206E, THR100E, THR105E, THR122E, THR155D, THR191D, THR194D, THR195D, THR196D, THR197D, THR209E, THR87E, TYR125E, VAL101E, VAL123E, VAL131E, VAL141E, VAL150D, VAL173D, VAL178D, VAL182D, VAL217D, VAL95E, VAL99E
• F-G: ALA121G, ALA124G, ALA16F, ALA177F, ALA190F, ALA193F, ALA216F, ALA216G, ARG102G, ARG139G, ARG153F, ARG17F, ARG185F, ARG188F, ARG210F, ARG210G, ARG215F, ARG215G, ARG218F, ASN138G, ASN208G, ASN221G, ASN91G, ASP103G, ASP176F, ASP189F, ASP96G, CYS110F, CYS181F, GLN142G, GLN151F, GLN156F, GLN157F, GLN207F, GLN207G, GLU111F, GLU152F, GLU20F, GLU212F, GLU212G, GLU90G, GLU97G, GLY119F, GLY119G, GLY133G, GLY186F, GLY18F, GLY200F, HIS113F, HIS179F, HIS211F, HIS211G, HIS219G, HIS220F, HIS220G, ILE104G, ILE117F, ILE126G, ILE132G, ILE137G, ILE140G, ILE175F, ILE187F, ILE89G, LEU106G, LEU134G, LEU154F, LEU159F, LEU199F, LEU19F, LEU202G, LEU214F, LYS120F, LYS120G, LYS136G, LYS183F, LYS204F, LYS92G, LYS94G, MET93G, MET98G, PHE143G, PHE203F, PHE213F, PHE213G, PRO127G, PRO22F, PRO84G, SER112F, SER135G, SER174F, SER192F, SER198F, SER205F, SER206F, SER206G, THR100G, THR105G, THR122G, THR155F, THR191F, THR194F, THR195F, THR196F, THR197F, THR209G, THR87G, TYR125G, VAL101G, VAL123G, VAL131G, VAL141G, VAL150F, VAL173F, VAL178F, VAL182F, VAL217F, VAL95G, VAL99G
• F-J: ALA121F, ALA124F, ALA177J, ALA190J, ALA193J, ALA216F, ALA216J, ARG102F, ARG139F, ARG153J, ARG17J, ARG185J, ARG188J, ARG210F, ARG210J, ARG215F, ARG215J, ARG218J, ASN138F, ASN208F, ASN221F, ASN91F, ASP103F, ASP176J, ASP189J, ASP96F, CYS110J, CYS181J, GLN142F, GLN146F, GLN151J, GLN156J, GLN157J, GLN207F, GLN207J, GLU111J, GLU152J, GLU20J, GLU212F, GLU212J, GLU97F, GLY119F, GLY119J, GLY133F, GLY186J, GLY18J, GLY200J, HIS113J, HIS179J, HIS211F, HIS211J, HIS219F, HIS219J, HIS220F, HIS220J, ILE104F, ILE117J, ILE126F, ILE132F, ILE137F, ILE140F, ILE175J, ILE187J, ILE89F, LEU106F, LEU134F, LEU154J, LEU159J, LEU199J, LEU19J, LEU202F, LEU214J, LYS120F, LYS120J, LYS136F, LYS183J, LYS204J, LYS92F, LYS94F, MET93F, MET98F, PHE143F, PHE203J, PHE213F, PHE213J, PRO127F, PRO22J, PRO84F, SER112J, SER135F, SER192J, SER198J, SER205J, SER206F, THR100F, THR105F, THR122F, THR155J, THR191J, THR194J, THR195J, THR196J, THR197J, THR209F, THR87F, TYR125F, VAL101F, VAL123F, VAL131F, VAL141F, VAL150J, VAL173J, VAL178J, VAL182J, VAL217J, VAL95F, VAL99F
• F-N: ARG24F, ARG24N, GLU45F, GLU45N, GLY41F, GLY41N, HIS42F, HIS42N, ILE39F, ILE39N, ILE46F, LEU38F, LEU38N, LEU49F, LEU49N, PRO25F, PRO25N, SER37F, SER37N, THR34F, THR34N, THR44F, VAL27F, VAL27N
• G-H: ALA121H, ALA124H, ALA16G, ALA177G, ALA190G, ALA193G, ALA216G, ALA216H, ARG102H, ARG139H, ARG153G, ARG17G, ARG185G, ARG188G, ARG210G, ARG210H, ARG215G, ARG215H, ARG218G, ASN138H, ASN208H, ASN221H, ASN91H, ASP103H, ASP176G, ASP189G, ASP96H, CYS110G, CYS181G, GLN142H, GLN151G, GLN156G, GLN157G, GLN207G, GLN207H, GLU111G, GLU152G, GLU20G, GLU212G, GLU212H, GLU90H, GLU97H, GLY119H, GLY133H, GLY186G, GLY18G, GLY200G, HIS113G, HIS179G, HIS211G, HIS211H, HIS219H, HIS220G, HIS220H, ILE104H, ILE117G, ILE126H, ILE132H, ILE137H, ILE140H, ILE175G, ILE187G, ILE89H, LEU106H, LEU134H, LEU154G, LEU159G, LEU199G, LEU19G, LEU214G, LYS120G, LYS120H, LYS136H, LYS183G, LYS204G, LYS92H, LYS94H, MET93H, MET98H, PHE143H, PHE203G, PHE213G, PHE213H, PRO127H, PRO22G, PRO84H, SER112G, SER135H, SER192G, SER198G, SER205G, SER206G, SER206H, THR100H, THR105H, THR122H, THR155G, THR191G, THR194G, THR195G, THR196G, THR197G, THR209H, THR87H, TYR125H, VAL101H, VAL123H, VAL131H, VAL141H, VAL150G, VAL173G, VAL178G, VAL182G, VAL217G, VAL95H, VAL99H
• H-I: ALA121I, ALA124I, ALA177H, ALA190H, ALA193H, ALA216H, ALA216I, ARG102I, ARG139I, ARG153H, ARG17H, ARG185H, ARG188H, ARG210H, ARG210I, ARG215H, ARG215I, ARG218H, ASN138I, ASN208I, ASN221I, ASN91I, ASP103I, ASP176H, ASP189H, ASP96I, CYS110H, CYS181H, GLN142I, GLN146I, GLN149H, GLN151H, GLN156H, GLN157H, GLN207H, GLN207I, GLU111H, GLU152H, GLU20H, GLU212H, GLU212I, GLU90I, GLU97I, GLY119I, GLY133I, GLY186H, GLY18H, GLY200H, HIS113H, HIS179H, HIS211H, HIS211I, HIS219H, HIS219I, HIS220H, HIS220I, ILE104I, ILE117H, ILE126I, ILE132I, ILE137I, ILE140I, ILE175H, ILE187H, ILE89I, LEU106I, LEU134I, LEU154H, LEU159H, LEU199H, LEU19H, LEU202I, LEU214H, LYS120H, LYS120I, LYS136I, LYS183H, LYS204H, LYS92I, LYS94I, MET93I, MET98I, PHE143I, PHE203H, PHE213H, PHE213I, PRO127I, PRO22H, PRO84I, SER112H, SER135I, SER192H, SER198H, SER205H, SER206H, SER206I, THR100I, THR105I, THR122I, THR155H, THR191H, THR194H, THR195H, THR196H, THR197H, THR209I, THR87I, TYR125I, TYR180H, VAL101I, VAL123I, VAL131I, VAL141I, VAL150H, VAL173H, VAL178H, VAL182H, VAL217H, VAL95I, VAL99I
• I-J: ALA121J, ALA124J, ALA177I, ALA190I, ALA193I, ALA216I, ALA216J, ARG102J, ARG139J, ARG153I, ARG17I, ARG185I, ARG188I, ARG210I, ARG210J, ARG215I, ARG215J, ARG218I, ASN138J, ASN208J, ASN221J, ASN91J, ASP103J, ASP176I, ASP189I, ASP96J, CYS110I, CYS181I, GLN142J, GLN146J, GLN151I, GLN156I, GLN157I, GLN207I, GLN207J, GLU111I, GLU152I, GLU20I, GLU212I, GLU212J, GLU90J, GLU97J, GLY119I, GLY119J, GLY133J, GLY186I, GLY18I, GLY200I, HIS113I, HIS179I, HIS211I, HIS211J, HIS219J, HIS220I, HIS220J, ILE104J, ILE117I, ILE126J, ILE132J, ILE137J, ILE140J, ILE175I, ILE187I, ILE89J, LEU106J, LEU134J, LEU154I, LEU159I, LEU199I, LEU19I, LEU202J, LEU214I, LYS120I, LYS120J, LYS136J, LYS183I, LYS204I, LYS92J, LYS94J, MET93J, MET98J, PHE143J, PHE203I, PHE213I, PHE213J, PRO127J, PRO22I, PRO84J, SER112I, SER135J, SER192I, SER198I, SER205I, SER206J, THR100J, THR105J, THR122J, THR155I, THR191I, THR194I, THR195I, THR196I, THR197I, THR209J, THR87J, TYR125J, VAL101J, VAL123J, VAL131J, VAL141J, VAL150I, VAL173I, VAL178I, VAL182I, VAL217I, VAL95J, VAL99J
• K-L: ALA121L, ALA124L, ALA16K, ALA177K, ALA190K, ALA193K, ALA216K, ALA216L, ARG102L, ARG139L, ARG153K, ARG17K, ARG185K, ARG188K, ARG210K, ARG210L, ARG215K, ARG215L, ARG218K, ASN138L, ASN208L, ASN221L, ASN91L, ASP103L, ASP176K, ASP189K, ASP96L, CYS110K, CYS181K, GLN142L, GLN146L, GLN149K, GLN151K, GLN156K, GLN157K, GLN207K, GLN207L, GLU111K, GLU152K, GLU20K, GLU212K, GLU212L, GLU90L, GLU97L, GLY119L, GLY133L, GLY186K, GLY18K, GLY200K, HIS113K, HIS179K, HIS211K, HIS211L, HIS219K, HIS219L, HIS220K, HIS220L, ILE104L, ILE117K, ILE126L, ILE132L, ILE137L, ILE140L, ILE175K, ILE187K, ILE89L, LEU106L, LEU134L, LEU154K, LEU159K, LEU199K, LEU19K, LEU202L, LEU214K, LYS120K, LYS120L, LYS136L, LYS183K, LYS204K, LYS92L, LYS94L, MET93L, MET98L, PHE143L, PHE203K, PHE213K, PHE213L, PRO127L, PRO22K, PRO84L, SER112K, SER135L, SER174K, SER192K, SER198K, SER205K, SER206K, SER206L, THR100L, THR105L, THR122L, THR155K, THR191K, THR194K, THR195K, THR196K, THR197K, THR209L, THR87L, TYR125L, VAL101L, VAL123L, VAL131L, VAL141L, VAL150K, VAL173K, VAL178K, VAL182K, VAL217K, VAL95L, VAL99L
• K-O: ALA121K, ALA124K, ALA16O, ALA177O, ALA190O, ALA193O, ALA216K, ALA216O, ARG102K, ARG139K, ARG153O, ARG17O, ARG185O, ARG188O, ARG210K, ARG210O, ARG215K, ARG215O, ARG218O, ASN138K, ASN208K, ASN221K, ASN91K, ASP103K, ASP176O, ASP189O, ASP96K, CYS110O, CYS181O, GLN142K, GLN151O, GLN156O, GLN157O, GLN207K, GLN207O, GLU111O, GLU152O, GLU20O, GLU212K, GLU212O, GLU90K, GLU97K, GLY119K, GLY119O, GLY133K, GLY186O, GLY18O, GLY200O, HIS113O, HIS179O, HIS211K, HIS211O, HIS219K, HIS220K, HIS220O, ILE104K, ILE117O, ILE126K, ILE132K, ILE137K, ILE140K, ILE160O, ILE175O, ILE187O, ILE89K, LEU106K, LEU134K, LEU154O, LEU159O, LEU199O, LEU19O, LEU202K, LEU214O, LYS120K, LYS120O, LYS136K, LYS183O, LYS204O, LYS92K, LYS94K, MET93K, MET98K, PHE143K, PHE203O, PHE213K, PHE213O, PRO127K, PRO22O, PRO84K, SER112O, SER135K, SER174O, SER192O, SER198O, SER205O, SER206K, SER206O, THR100K, THR105K, THR122K, THR155O, THR191O, THR194O, THR195O, THR196O, THR197O, THR209K, THR87K, TYR125K, VAL101K, VAL123K, VAL131K, VAL141K, VAL150O, VAL173O, VAL178O, VAL182O, VAL217O, VAL95K, VAL99K
• L-M: ALA121M, ALA124M, ALA16L, ALA177L, ALA190L, ALA193L, ALA216L, ALA216M, ARG102M, ARG139M, ARG153L, ARG17L, ARG185L, ARG188L, ARG210L, ARG210M, ARG215L, ARG215M, ARG218L, ASN138M, ASN208M, ASN221M, ASN91M, ASP103M, ASP176L, ASP189L, ASP96M, CYS110L, CYS181L, GLN142M, GLN146M, GLN151L, GLN156L, GLN157L, GLN207L, GLN207M, GLU111L, GLU152L, GLU20L, GLU212L, GLU212M, GLU90M, GLU97M, GLY119L, GLY119M, GLY133M, GLY186L, GLY18L, GLY200L, HIS113L, HIS179L, HIS211L, HIS211M, HIS219M, HIS220L, HIS220M, ILE104M, ILE117L, ILE126M, ILE132M, ILE137M, ILE140M, ILE160L, ILE175L, ILE187L, ILE89M, LEU106M, LEU134M, LEU154L, LEU159L, LEU199L, LEU19L, LEU202M, LEU214L, LYS120L, LYS120M, LYS136M, LYS183L, LYS204L, LYS92M, LYS94M, MET93M, MET98M, PHE143M, PHE203L, PHE213L, PHE213M, PRO127M, PRO22L, PRO84M, SER112L, SER135M, SER192L, SER198L, SER205L, SER206M, THR100M, THR105M, THR122M, THR155L, THR191L, THR194L, THR195L, THR196L, THR197L, THR209M, THR87M, TYR125M, VAL101M, VAL123M, VAL131M, VAL141M, VAL150L, VAL173L, VAL178L, VAL182L, VAL217L, VAL95M, VAL99M
• M-N: ALA121N, ALA124N, ALA177M, ALA190M, ALA193M, ALA216M, ALA216N, ARG102N, ARG139N, ARG153M, ARG17M, ARG185M, ARG188M, ARG210M, ARG210N, ARG215M, ARG215N, ARG218M, ASN138N, ASN208N, ASN221N, ASN91N, ASP103N, ASP176M, ASP189M, ASP96N, CYS110M, CYS181M, GLN142N, GLN146N, GLN149M, GLN151M, GLN156M, GLN157M, GLN207M, GLN207N, GLU111M, GLU152M, GLU20M, GLU212M, GLU212N, GLU90N, GLU97N, GLY119M, GLY119N, GLY133N, GLY186M, GLY18M, GLY200M, HIS113M, HIS179M, HIS211M, HIS211N, HIS219M, HIS219N, HIS220M, HIS220N, ILE104N, ILE117M, ILE126N, ILE132N, ILE137N, ILE140N, ILE175M, ILE187M, ILE89N, LEU106N, LEU134N, LEU154M, LEU159M, LEU199M, LEU19M, LEU202N, LEU214M, LYS120M, LYS120N, LYS136N, LYS183M, LYS204M, LYS92N, LYS94N, MET93N, MET98N, PHE143N, PHE203M, PHE213M, PHE213N, PRO127N, PRO22M, PRO84N, SER112M, SER135N, SER192M, SER198M, SER205M, SER206N, THR100N, THR105N, THR122N, THR155M, THR191M, THR194M, THR195M, THR196M, THR197M, THR209N, THR21M, THR87N, TYR125N, VAL101N, VAL123N, VAL131N, VAL141N, VAL150M, VAL173M, VAL178M, VAL182M, VAL217M, VAL95N, VAL99N
• N-O: ALA121O, ALA124O, ALA16N, ALA172N, ALA177N, ALA190N, ALA193N, ALA216N, ALA216O, ARG102O, ARG139O, ARG153N, ARG17N, ARG185N, ARG188N, ARG210N, ARG210O, ARG215N, ARG215O, ARG218N, ASN138O, ASN208O, ASN221O, ASN91O, ASP103O, ASP176N, ASP189N, ASP96O, CYS110N, CYS181N, GLN142O, GLN146O, GLN149N, GLN151N, GLN156N, GLN157N, GLN207N, GLN207O, GLU111N, GLU152N, GLU20N, GLU212N, GLU212O, GLU90O, GLU97O, GLY119N, GLY119O, GLY133O, GLY186N, GLY18N, GLY200N, HIS113N, HIS179N, HIS211N, HIS211O, HIS219N, HIS219O, HIS220N, HIS220O, ILE104O, ILE117N, ILE126O, ILE132O, ILE137O, ILE140O, ILE160N, ILE175N, ILE187N, ILE89O, LEU106O, LEU134O, LEU154N, LEU159N, LEU199N, LEU19N, LEU202O, LEU214N, LYS120N, LYS120O, LYS136O, LYS183N, LYS204N, LYS92O, LYS94O, MET93O, MET98O, PHE143O, PHE203N, PHE213N, PHE213O, PRO127O, PRO22N, PRO84O, SER112N, SER130O, SER135O, SER192N, SER198N, SER205N, SER206O, THR100O, THR105O, THR122O, THR155N, THR191N, THR194N, THR195N, THR196N, THR197N, THR209O, THR21N, THR87O, TYR125O, VAL101O, VAL123O, VAL131O, VAL141O, VAL150N, VAL173N, VAL178N, VAL182N, VAL217N, VAL95O, VAL99O