1MX9

crystal structure of human liver carboxylesterase in complexed with naloxone methiodide, a heroin analogue

• Total interactions analyzed: 66
• Total true interactions: 21
• Strongest Interaction:
  • Chains: I-J
  • Int. Res.: 161
  • Norm. En. per Res.: -2.9504
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-3.1917	-45.2197	-104.792	-153.2034	66	5	1	4888	2	29	19
A-C	-5.3942	-39.8624	-96.2336	-141.4903	67	4	1	4761	2	29	19
A-F	-30.8895	-16.051	-367.313	-414.2535	166	27	5	17899	7	64	66
A-G	0.0	6.2793	-0.0745	6.2049	8	0	0	28	0	5	4
A-L	-45.594	-1.3441	-86.2601	-133.1981	64	9	1	3179	2	25	21
B-C	-22.1693	-43.6932	-98.2991	-164.1616	68	6	1	4887	2	29	19
B-E	-41.5122	-2.4341	-361.396	-405.3423	169	22	4	17520	8	66	67
C-D	-49.1674	-10.1592	-387.989	-447.3156	161	39	5	18215	10	63	63
D-E	-10.5665	-49.836	-105.378	-165.7805	72	6	1	4996	2	30	19
D-F	-13.8139	-43.8673	-103.542	-161.2232	69	3	1	4823	2	29	19
E-F	-22.6307	-44.6026	-105.362	-172.5953	70	2	1	4873	2	28	19
G-H	-30.7777	-38.6901	-94.9546	-164.4225	69	5	1	4697	2	29	19
G-I	-3.5919	-44.1032	-107.256	-154.9511	65	3	1	4839	2	29	19
G-J	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	0	0
G-L	-31.5515	21.8438	-375.669	-385.3767	156	37	5	17387	5	62	68
H-I	-2.9872	-38.3365	-107.274	-148.5978	67	2	1	5018	2	29	19
H-K	-57.9966	-12.793	-380.302	-451.0916	171	24	5	18007	10	62	65
I-J	-50.3357	-18.9733	-405.699	-475.008	161	40	4	18135	10	62	66
J-K	-7.5619	-37.1573	-101.799	-146.5182	64	2	1	4761	2	29	19
J-L	-19.204	-38.4222	-97.642	-155.2682	65	3	1	4631	2	29	19
K-L	-4.728	-43.1346	-107.03	-154.8926	66	5	1	5073	2	29	21

Interface residues

• A-B: ALA1056A, ALA1071A, ALA2280B, ARG1064A, ARG1287A, ARG2186B, ARG2287B, ASN1079A, ASP1115A, ASP2182B, ASP2324B, CYS1116A, CYS2285B, GLN1288A, GLN2288B, GLU1072A, GLU1114A, GLU1291A, GLU1292A, GLU2183B, GLY1031A, GLY1061A, GLY2181B, GLY2325B, HIS1030A, HIS2184B, HIS2284B, ILE2323B, LEU1060A, LEU1063A, LEU1112A, LEU1295A, LEU2328B, LEU2329B, LYS1057A, LYS1078A, LYS1111A, LYS1289A, LYS2275B, LYS2330B, MET1086A, MET2282B, MET2326B, PHE1076A, PRO1054A, PRO1058A, PRO1059A, PRO1062A, PRO1073A, PRO1084A, PRO1085A, PRO2062B, SER1075A, SER1113A, SER2279B, THR1290A, THR2276B, THR2277B, THR2278B, TRP1074A, TYR1083A, TYR1118A, VAL1077A, VAL2281B, VAL2283B, VAL2322B
• A-C: ALA1280A, ALA3056C, ALA3071C, ARG1186A, ARG1287A, ARG3064C, ARG3287C, ASN3079C, ASP1182A, ASP1324A, ASP3115C, CYS1285A, CYS3116C, GLN1288A, GLN3288C, GLU1183A, GLU3072C, GLU3114C, GLU3291C, GLU3292C, GLY1181A, GLY1325A, GLY3031C, GLY3061C, HIS1184A, HIS1284A, HIS3030C, ILE1323A, LEU1328A, LEU1329A, LEU3060C, LEU3063C, LEU3112C, LEU3117C, LYS1275A, LYS1330A, LYS3057C, LYS3078C, LYS3111C, LYS3289C, MET1282A, MET1326A, MET3086C, PHE3076C, PRO1062A, PRO3054C, PRO3058C, PRO3059C, PRO3062C, PRO3073C, PRO3084C, PRO3085C, SER1279A, SER3075C, SER3113C, THR1180A, THR1276A, THR1277A, THR1278A, THR1331A, THR3290C, TRP3074C, TYR3083C, TYR3118C, VAL1281A, VAL1283A, VAL1322A
• A-F: ALA1093A, ALA1378A, ALA6093F, ALA6378F, ARG1452A, ARG6452F, ASN1107A, ASN6107F, ASP1090A, ASP1307A, ASP1374A, ASP1409A, ASP1415A, ASP1458A, ASP1467A, ASP6090F, ASP6307F, ASP6374F, ASP6415F, ASP6458F, ASP6467F, GLN1095A, GLN1267A, GLN1309A, GLN1316A, GLN1353A, GLN1372A, GLN1375A, GLN6095F, GLN6267F, GLN6309F, GLN6316F, GLN6353F, GLN6372F, GLN6375F, GLU1099A, GLU1292A, GLU1293A, GLU1296A, GLU1370A, GLU6099F, GLU6292F, GLU6293F, GLU6296F, GLU6370F, GLY1094A, GLY1273A, GLY1310A, GLY1356A, GLY1371A, GLY6094F, GLY6310F, GLY6356F, GLY6371F, ILE1465A, ILE6359F, ILE6465F, LEU1096A, LEU1097A, LEU1100A, LEU1295A, LEU1299A, LEU1306A, LEU1308A, LEU1358A, LEU1363A, LEU1368A, LEU1373A, LEU1381A, LEU1382A, LEU1418A, LEU6096F, LEU6097F, LEU6100F, LEU6295F, LEU6299F, LEU6306F, LEU6308F, LEU6358F, LEU6363F, LEU6368F, LEU6373F, LEU6381F, LEU6382F, LEU6418F, LYS1092A, LYS1300A, LYS1302A, LYS1376A, LYS1384A, LYS1393A, LYS1412A, LYS1414A, LYS1460A, LYS1462A, LYS6092F, LYS6300F, LYS6302F, LYS6376F, LYS6384F, LYS6412F, LYS6413F, LYS6414F, LYS6460F, LYS6462F, MET1301A, MET1361A, MET1364A, MET1379A, MET1459A, MET6301F, MET6361F, MET6364F, MET6379F, MET6459F, PHE1303A, PHE1355A, PHE6303F, PHE6355F, PHE6417F, PRO1091A, PRO1360A, PRO1367A, PRO1461A, PRO6091F, PRO6360F, PRO6367F, PRO6461F, SER1098A, SER1305A, SER1315A, SER1365A, SER1369A, SER1380A, SER1454A, SER1456A, SER1457A, SER6305F, SER6315F, SER6365F, SER6369F, SER6380F, SER6454F, SER6456F, SER6457F, THR1271A, THR1297A, THR1298A, THR1377A, THR1410A, THR1463A, THR6271F, THR6297F, THR6377F, THR6410F, THR6463F, TRP1357A, TRP1383A, TRP6357F, TRP6383F, TYR1366A, TYR6366F, VAL1411A, VAL1464A, VAL6411F, VAL6464F
• A-G: ALA1044A, GLU1041A, GLU1394G, GLU1483A, GLY1042A, LYS1376G, LYS1393G, SER1039A
• A-L: ALA1044A, ALA1125A, ALA1159A, ALA6485L, ARG1132A, ARG1491A, ARG1505A, ARG6452L, ARG6491L, ASN1131A, ASN1162A, ASN1502A, ASN1506A, ASN1510A, ASN6532L, ASP1126A, ASP6458L, GLN1045A, GLU1041A, GLU1161A, GLU1487A, GLU1512A, GLU6041L, GLU6106L, GLU6483L, GLU6487L, GLU6488L, GLU6489L, GLY1042A, GLY1209A, GLY1511A, GLY1513A, GLY6042L, GLY6484L, HIS1160A, ILE1490A, ILE6490L, LEU1040A, LEU1127A, LEU1133A, LEU1514A, LEU6040L, LEU6155L, LYS1129A, LYS1494A, LYS1498A, LYS6105L, LYS6462L, LYS6482L, MET1497A, PHE1043A, PHE1480A, PHE6037L, PHE6455L, PRO1046A, PRO1124A, PRO6046L, PRO6453L, SER6039L, SER6454L, SER6486L, THR1128A, TYR6451L, VAL6038L
• B-C: ALA2056B, ALA2071B, ALA3280C, ARG2064B, ARG2287B, ARG3186C, ARG3287C, ASN2079B, ASP2115B, ASP3182C, ASP3324C, CYS2116B, CYS3285C, GLN2288B, GLN3288C, GLU2072B, GLU2114B, GLU2291B, GLU2292B, GLU3183C, GLY2031B, GLY2061B, GLY3181C, GLY3325C, HIS2030B, HIS3184C, HIS3284C, ILE3323C, LEU2060B, LEU2063B, LEU2112B, LEU2295B, LEU3327C, LEU3328C, LEU3329C, LYS2057B, LYS2078B, LYS2111B, LYS2289B, LYS3275C, LYS3330C, MET2086B, MET3282C, MET3326C, PHE2076B, PRO2054B, PRO2058B, PRO2059B, PRO2062B, PRO2073B, PRO2084B, PRO2085B, PRO3062C, SER2075B, SER2113B, SER3279C, THR2088B, THR2290B, THR3276C, THR3277C, THR3278C, THR3331C, TRP2074B, TYR2083B, TYR2118B, VAL3281C, VAL3283C, VAL3322C
• B-E: ALA2093B, ALA2378B, ALA5093E, ALA5378E, ARG2452B, ARG5452E, ASN2107B, ASN5107E, ASP2090B, ASP2307B, ASP2374B, ASP2408B, ASP2409B, ASP2415B, ASP2458B, ASP2467B, ASP5090E, ASP5307E, ASP5374E, ASP5408E, ASP5409E, ASP5415E, ASP5458E, GLN2095B, GLN2267B, GLN2309B, GLN2353B, GLN2372B, GLN2375B, GLN5095E, GLN5267E, GLN5309E, GLN5353E, GLN5372E, GLN5375E, GLU2099B, GLU2292B, GLU2293B, GLU2296B, GLU2370B, GLU5099E, GLU5292E, GLU5293E, GLU5296E, GLU5370E, GLY2094B, GLY2310B, GLY2356B, GLY2371B, GLY5094E, GLY5310E, GLY5356E, GLY5371E, ILE2359B, ILE2465B, ILE5359E, ILE5465E, LEU2096B, LEU2097B, LEU2100B, LEU2295B, LEU2299B, LEU2304B, LEU2306B, LEU2308B, LEU2358B, LEU2363B, LEU2368B, LEU2373B, LEU2381B, LEU2382B, LEU2418B, LEU5096E, LEU5097E, LEU5100E, LEU5295E, LEU5299E, LEU5306E, LEU5308E, LEU5358E, LEU5363E, LEU5368E, LEU5373E, LEU5381E, LEU5382E, LEU5418E, LYS2092B, LYS2300B, LYS2302B, LYS2376B, LYS2384B, LYS2412B, LYS2413B, LYS2414B, LYS2460B, LYS2462B, LYS5092E, LYS5300E, LYS5302E, LYS5376E, LYS5384E, LYS5393E, LYS5412E, LYS5413E, LYS5414E, LYS5460E, LYS5462E, MET2301B, MET2361B, MET2364B, MET2379B, MET2459B, MET5301E, MET5361E, MET5364E, MET5379E, MET5459E, PHE2303B, PHE2355B, PHE5303E, PHE5355E, PHE5417E, PRO2091B, PRO2109B, PRO2360B, PRO2367B, PRO2461B, PRO5091E, PRO5109E, PRO5312E, PRO5360E, PRO5367E, PRO5461E, SER2305B, SER2315B, SER2365B, SER2369B, SER2380B, SER2454B, SER2456B, SER2457B, SER5305E, SER5365E, SER5369E, SER5380E, SER5454E, SER5456E, SER5457E, THR2271B, THR2297B, THR2377B, THR2410B, THR2463B, THR5271E, THR5297E, THR5298E, THR5377E, THR5410E, THR5463E, TRP2357B, TRP2383B, TRP5357E, TRP5383E, TYR2366B, TYR5366E, VAL2411B, VAL2464B, VAL5411E, VAL5464E
• C-D: ALA3093C, ALA3378C, ALA4093D, ALA4378D, ARG3452C, ARG4452D, ASN3107C, ASP3090C, ASP3307C, ASP3374C, ASP3409C, ASP3415C, ASP3458C, ASP3467C, ASP4090D, ASP4307D, ASP4374D, ASP4409D, ASP4415D, ASP4458D, GLN3095C, GLN3267C, GLN3309C, GLN3316C, GLN3353C, GLN3372C, GLN3375C, GLN4095D, GLN4267D, GLN4309D, GLN4353D, GLN4372D, GLN4375D, GLU3099C, GLU3292C, GLU3293C, GLU3296C, GLU3370C, GLU4099D, GLU4292D, GLU4293D, GLU4296D, GLU4370D, GLY3094C, GLY3310C, GLY3356C, GLY3371C, GLY4094D, GLY4310D, GLY4356D, GLY4371D, ILE3359C, ILE3465C, ILE4465D, LEU3096C, LEU3097C, LEU3100C, LEU3295C, LEU3299C, LEU3304C, LEU3306C, LEU3308C, LEU3358C, LEU3363C, LEU3368C, LEU3373C, LEU3381C, LEU3382C, LEU3418C, LEU4096D, LEU4097D, LEU4100D, LEU4295D, LEU4299D, LEU4306D, LEU4308D, LEU4358D, LEU4363D, LEU4368D, LEU4373D, LEU4381D, LEU4382D, LEU4418D, LYS3092C, LYS3300C, LYS3302C, LYS3376C, LYS3384C, LYS3412C, LYS3414C, LYS3460C, LYS3462C, LYS4092D, LYS4300D, LYS4302D, LYS4376D, LYS4384D, LYS4412D, LYS4414D, LYS4460D, LYS4462D, MET3301C, MET3361C, MET3364C, MET3379C, MET3459C, MET4301D, MET4361D, MET4364D, MET4379D, MET4459D, PHE3303C, PHE3355C, PHE4303D, PHE4355D, PHE4417D, PHE4455D, PRO3091C, PRO3360C, PRO3367C, PRO3461C, PRO4091D, PRO4360D, PRO4367D, PRO4461D, SER3305C, SER3315C, SER3365C, SER3369C, SER3380C, SER3454C, SER3456C, SER3457C, SER4098D, SER4305D, SER4365D, SER4369D, SER4380D, SER4454D, SER4456D, SER4457D, THR3297C, THR3377C, THR3410C, THR3463C, THR4271D, THR4297D, THR4298D, THR4377D, THR4410D, THR4463D, TRP3357C, TRP3383C, TRP4357D, TRP4383D, TYR3366C, TYR4366D, VAL3411C, VAL3464C, VAL4411D, VAL4464D
• D-E: ALA4056D, ALA4071D, ALA5280E, ARG4064D, ARG4287D, ARG5186E, ARG5287E, ASN4079D, ASP4115D, ASP5182E, ASP5324E, CYS4116D, CYS5285E, GLN4288D, GLN5288E, GLU4072D, GLU4114D, GLU4291D, GLU4292D, GLU5183E, GLU5334E, GLY4031D, GLY4061D, GLY5181E, GLY5325E, HIS4030D, HIS5184E, HIS5284E, ILE5323E, LEU4060D, LEU4063D, LEU4112D, LEU4117D, LEU4295D, LEU5327E, LEU5328E, LEU5329E, LYS4057D, LYS4078D, LYS4111D, LYS4289D, LYS5275E, LYS5330E, MET4086D, MET5282E, MET5326E, PHE4076D, PRO4054D, PRO4058D, PRO4059D, PRO4062D, PRO4073D, PRO4084D, PRO4085D, PRO5062E, SER4075D, SER4113D, SER5279E, THR4088D, THR4290D, THR5066E, THR5276E, THR5277E, THR5278E, THR5331E, TRP4074D, TYR4083D, TYR4118D, VAL4077D, VAL5281E, VAL5283E, VAL5322E
• D-F: ALA4280D, ALA6056F, ALA6071F, ARG4186D, ARG4287D, ARG6064F, ARG6287F, ASN4188D, ASN6079F, ASP4182D, ASP4324D, ASP6115F, CYS4285D, CYS6116F, GLN4288D, GLN6288F, GLU4183D, GLU6072F, GLU6114F, GLU6291F, GLU6292F, GLY4181D, GLY4325D, GLY6031F, GLY6061F, HIS4184D, HIS4284D, HIS6030F, ILE4323D, LEU4327D, LEU4328D, LEU4329D, LEU6060F, LEU6063F, LEU6112F, LEU6117F, LYS4275D, LYS4330D, LYS6057F, LYS6078F, LYS6111F, LYS6289F, MET4282D, MET4326D, MET6086F, PHE6076F, PRO4062D, PRO6054F, PRO6058F, PRO6059F, PRO6062F, PRO6073F, PRO6084F, PRO6085F, SER4279D, SER6075F, SER6113F, THR4066D, THR4276D, THR4277D, THR4278D, THR4331D, THR6290F, TRP6074F, TYR6083F, TYR6118F, VAL4281D, VAL4283D, VAL4322D
• E-F: ALA5056E, ALA5071E, ALA6280F, ARG5064E, ARG5287E, ARG6186F, ARG6287F, ASN5079E, ASP5115E, ASP6182F, ASP6324F, CYS5116E, CYS6285F, GLN5288E, GLN6288F, GLU5072E, GLU5114E, GLU5291E, GLU5292E, GLU6183F, GLY5061E, GLY6181F, GLY6325F, HIS5030E, HIS6184F, HIS6284F, ILE6323F, LEU5060E, LEU5063E, LEU5110E, LEU5112E, LEU5295E, LEU6327F, LEU6328F, LEU6329F, LYS5057E, LYS5078E, LYS5111E, LYS5289E, LYS6275F, LYS6330F, MET5086E, MET6282F, MET6326F, PHE5076E, PRO5054E, PRO5058E, PRO5059E, PRO5062E, PRO5073E, PRO5084E, PRO5085E, PRO6062F, SER5075E, SER5113E, SER6279F, THR5088E, THR5290E, THR6066F, THR6276F, THR6277F, THR6278F, THR6331F, TRP5074E, TYR5083E, TYR5118E, VAL5077E, VAL6281F, VAL6283F, VAL6322F
• G-H: ALA1056G, ALA1071G, ALA2280H, ARG1064G, ARG1287G, ARG2186H, ARG2287H, ASN1079G, ASN2188H, ASP1115G, ASP2182H, ASP2324H, CYS1116G, CYS2285H, GLN1288G, GLN2288H, GLU1072G, GLU1114G, GLU1291G, GLU1292G, GLU2183H, GLU2334H, GLY1061G, GLY2181H, GLY2325H, HIS1030G, HIS2184H, HIS2284H, ILE2323H, LEU1060G, LEU1063G, LEU1112G, LEU2328H, LEU2329H, LYS1057G, LYS1078G, LYS1111G, LYS1289G, LYS2275H, LYS2330H, MET1086G, MET2282H, MET2326H, PHE1076G, PRO1054G, PRO1058G, PRO1059G, PRO1062G, PRO1073G, PRO1084G, PRO1085G, PRO2062H, SER1075G, SER1113G, SER2279H, THR1088G, THR1290G, THR2066H, THR2276H, THR2277H, THR2278H, THR2331H, TRP1074G, TYR1083G, TYR1118G, VAL1077G, VAL2281H, VAL2283H, VAL2322H
• G-I: ALA1280G, ALA3056I, ALA3071I, ARG1186G, ARG1287G, ARG3064I, ARG3287I, ASN3079I, ASP1182G, ASP1324G, ASP3115I, CYS1285G, CYS3116I, GLN1288G, GLN3288I, GLU1183G, GLU3072I, GLU3114I, GLU3291I, GLU3292I, GLY1181G, GLY1325G, GLY3061I, HIS1184G, HIS1284G, HIS3030I, ILE1323G, LEU1327G, LEU1328G, LEU1329G, LEU3060I, LEU3063I, LEU3112I, LYS1275G, LYS1330G, LYS3057I, LYS3078I, LYS3111I, LYS3289I, MET1282G, MET1326G, MET3086I, PHE3076I, PRO1062G, PRO3054I, PRO3058I, PRO3059I, PRO3062I, PRO3073I, PRO3084I, PRO3085I, SER1279G, SER3075I, SER3113I, THR1277G, THR1278G, THR1331G, THR3290I, TRP3074I, TYR3083I, TYR3118I, VAL1281G, VAL1283G, VAL1322G, VAL3077I
• G-J: GLY1273G, LYS4275J
• G-L: ALA1093G, ALA1378G, ALA6093L, ALA6378L, ARG1452G, ARG6452L, ASN6107L, ASP1090G, ASP1307G, ASP1374G, ASP1409G, ASP1415G, ASP1458G, ASP6090L, ASP6307L, ASP6374L, ASP6409L, ASP6415L, ASP6458L, ASP6467L, GLN1095G, GLN1309G, GLN1353G, GLN1372G, GLN6095L, GLN6267L, GLN6309L, GLN6353L, GLN6372L, GLN6375L, GLU1099G, GLU1292G, GLU1293G, GLU1296G, GLU1370G, GLU6099L, GLU6292L, GLU6293L, GLU6296L, GLU6370L, GLY1094G, GLY1310G, GLY1356G, GLY1371G, GLY6310L, GLY6356L, GLY6371L, ILE1465G, ILE6359L, ILE6465L, LEU1096G, LEU1097G, LEU1100G, LEU1295G, LEU1299G, LEU1306G, LEU1308G, LEU1358G, LEU1363G, LEU1368G, LEU1373G, LEU1381G, LEU1382G, LEU1418G, LEU6096L, LEU6097L, LEU6100L, LEU6295L, LEU6299L, LEU6304L, LEU6306L, LEU6308L, LEU6358L, LEU6363L, LEU6368L, LEU6373L, LEU6381L, LEU6382L, LEU6418L, LYS1092G, LYS1300G, LYS1302G, LYS1376G, LYS1384G, LYS1393G, LYS1412G, LYS1414G, LYS1460G, LYS1462G, LYS6092L, LYS6300L, LYS6302L, LYS6376L, LYS6384L, LYS6393L, LYS6412L, LYS6413L, LYS6414L, LYS6460L, LYS6462L, MET1301G, MET1361G, MET1364G, MET1379G, MET1459G, MET6301L, MET6361L, MET6364L, MET6379L, MET6459L, PHE1303G, PHE1355G, PHE1417G, PHE6303L, PHE6355L, PRO1091G, PRO1360G, PRO1367G, PRO1461G, PRO6091L, PRO6360L, PRO6367L, PRO6461L, SER1098G, SER1305G, SER1365G, SER1369G, SER1380G, SER1457G, SER6098L, SER6305L, SER6365L, SER6369L, SER6380L, SER6454L, SER6457L, THR1297G, THR1298G, THR1377G, THR1410G, THR1463G, THR6297L, THR6298L, THR6377L, THR6410L, THR6463L, TRP1357G, TRP1383G, TRP6357L, TRP6383L, TYR1366G, TYR6366L, VAL1411G, VAL1464G, VAL6411L, VAL6464L
• H-I: ALA2056H, ALA2071H, ALA3280I, ARG2064H, ARG2287H, ARG3186I, ARG3287I, ASN2079H, ASP2115H, ASP3182I, ASP3324I, CYS2116H, CYS3285I, GLN2288H, GLN3288I, GLU2072H, GLU2114H, GLU2291H, GLU2292H, GLU3183I, GLY2061H, GLY3181I, GLY3325I, HIS2030H, HIS3184I, HIS3284I, ILE3323I, LEU2060H, LEU2063H, LEU2110H, LEU2112H, LEU2295H, LEU3328I, LEU3329I, LYS2057H, LYS2078H, LYS2111H, LYS2289H, LYS3275I, LYS3330I, MET2086H, MET3282I, MET3326I, PHE2076H, PRO2054H, PRO2058H, PRO2059H, PRO2062H, PRO2073H, PRO2084H, PRO2085H, PRO3062I, SER2075H, SER2113H, SER3279I, THR2290H, THR3276I, THR3277I, THR3278I, THR3331I, TRP2074H, TYR2083H, TYR2118H, VAL2077H, VAL3281I, VAL3283I, VAL3322I
• H-K: ALA2093H, ALA2378H, ALA5093K, ALA5378K, ARG2452H, ARG5452K, ASN5107K, ASP2090H, ASP2307H, ASP2374H, ASP2408H, ASP2415H, ASP2458H, ASP5090K, ASP5307K, ASP5374K, ASP5408K, ASP5409K, ASP5415K, ASP5458K, ASP5467K, GLN2095H, GLN2267H, GLN2309H, GLN2353H, GLN2372H, GLN2375H, GLN5095K, GLN5267K, GLN5309K, GLN5316K, GLN5353K, GLN5372K, GLN5375K, GLU2099H, GLU2292H, GLU2293H, GLU2296H, GLU2370H, GLU5099K, GLU5292K, GLU5293K, GLU5296K, GLU5370K, GLY2094H, GLY2310H, GLY2356H, GLY2371H, GLY5094K, GLY5310K, GLY5356K, GLY5371K, ILE2359H, ILE2465H, ILE5465K, LEU2096H, LEU2097H, LEU2100H, LEU2295H, LEU2299H, LEU2304H, LEU2306H, LEU2308H, LEU2358H, LEU2363H, LEU2368H, LEU2373H, LEU2381H, LEU2382H, LEU2418H, LEU5096K, LEU5097K, LEU5100K, LEU5110K, LEU5295K, LEU5299K, LEU5304K, LEU5306K, LEU5308K, LEU5358K, LEU5363K, LEU5368K, LEU5373K, LEU5381K, LEU5382K, LEU5418K, LYS2092H, LYS2300H, LYS2302H, LYS2376H, LYS2384H, LYS2393H, LYS2412H, LYS2413H, LYS2414H, LYS2460H, LYS2462H, LYS5092K, LYS5300K, LYS5302K, LYS5376K, LYS5384K, LYS5412K, LYS5413K, LYS5414K, LYS5460K, LYS5462K, MET2301H, MET2361H, MET2364H, MET2379H, MET2459H, MET5301K, MET5361K, MET5364K, MET5379K, MET5459K, PHE2303H, PHE2355H, PHE5303K, PHE5355K, PRO2091H, PRO2109H, PRO2360H, PRO2367H, PRO2453H, PRO2461H, PRO5091K, PRO5109K, PRO5360K, PRO5367K, PRO5461K, SER2305H, SER2315H, SER2365H, SER2369H, SER2380H, SER2454H, SER2456H, SER2457H, SER5098K, SER5305K, SER5315K, SER5365K, SER5369K, SER5380K, SER5385K, SER5454K, SER5457K, THR2271H, THR2297H, THR2298H, THR2377H, THR2410H, THR2463H, THR5271K, THR5297K, THR5298K, THR5377K, THR5410K, THR5463K, TRP2357H, TRP2383H, TRP5357K, TRP5383K, TYR2366H, TYR5366K, VAL2411H, VAL2464H, VAL5411K, VAL5464K
• I-J: ALA3093I, ALA3378I, ALA4093J, ALA4378J, ARG3452I, ARG4452J, ASN3107I, ASP3090I, ASP3307I, ASP3374I, ASP3415I, ASP3458I, ASP3467I, ASP4090J, ASP4307J, ASP4374J, ASP4409J, ASP4415J, ASP4458J, GLN3095I, GLN3267I, GLN3309I, GLN3316I, GLN3353I, GLN3372I, GLN3375I, GLN4095J, GLN4267J, GLN4309J, GLN4316J, GLN4353J, GLN4372J, GLN4375J, GLU3099I, GLU3292I, GLU3293I, GLU3296I, GLU3370I, GLU4099J, GLU4292J, GLU4293J, GLU4296J, GLU4370J, GLY3094I, GLY3310I, GLY3356I, GLY3371I, GLY4094J, GLY4310J, GLY4356J, GLY4371J, ILE3359I, ILE3465I, LEU3096I, LEU3097I, LEU3100I, LEU3295I, LEU3299I, LEU3306I, LEU3308I, LEU3358I, LEU3363I, LEU3368I, LEU3373I, LEU3381I, LEU3382I, LEU3418I, LEU4096J, LEU4097J, LEU4100J, LEU4295J, LEU4299J, LEU4306J, LEU4308J, LEU4358J, LEU4363J, LEU4368J, LEU4373J, LEU4381J, LEU4382J, LEU4418J, LYS3092I, LYS3300I, LYS3302I, LYS3376I, LYS3384I, LYS3412I, LYS3414I, LYS3460I, LYS3462I, LYS4092J, LYS4300J, LYS4302J, LYS4376J, LYS4384J, LYS4412J, LYS4414J, LYS4460J, LYS4462J, MET3301I, MET3361I, MET3364I, MET3379I, MET3459I, MET4301J, MET4361J, MET4364J, MET4379J, MET4459J, PHE3303I, PHE3355I, PHE4303J, PHE4355J, PRO3091I, PRO3360I, PRO3367I, PRO3461I, PRO4091J, PRO4360J, PRO4367J, PRO4461J, SER3098I, SER3305I, SER3315I, SER3365I, SER3369I, SER3380I, SER3385I, SER3454I, SER3456I, SER3457I, SER4098J, SER4305J, SER4315J, SER4365J, SER4369J, SER4380J, SER4454J, SER4456J, SER4457J, THR3271I, THR3297I, THR3377I, THR3410I, THR3463I, THR4271J, THR4297J, THR4298J, THR4377J, THR4410J, THR4463J, TRP3357I, TRP3383I, TRP4357J, TRP4383J, TYR3366I, TYR4366J, VAL3411I, VAL3464I, VAL4411J, VAL4464J
• J-K: ALA4056J, ALA4071J, ALA5280K, ARG4064J, ARG4287J, ARG5186K, ARG5287K, ASN4079J, ASP4115J, ASP5182K, ASP5324K, CYS4116J, CYS5285K, GLN4288J, GLN5288K, GLU4072J, GLU4114J, GLU4291J, GLU4292J, GLU5183K, GLY4061J, GLY5181K, GLY5325K, HIS4030J, HIS5184K, HIS5284K, ILE5323K, LEU4060J, LEU4063J, LEU4112J, LEU5328K, LEU5329K, LYS4057J, LYS4078J, LYS4111J, LYS4289J, LYS5275K, LYS5330K, MET4086J, MET5282K, MET5326K, PHE4076J, PRO4054J, PRO4058J, PRO4059J, PRO4062J, PRO4073J, PRO4084J, PRO4085J, PRO5062K, SER4075J, SER4113J, SER5279K, THR4290J, THR5276K, THR5277K, THR5278K, THR5331K, TRP4074J, TYR4083J, TYR4118J, VAL5281K, VAL5283K, VAL5322K
• J-L: ALA4280J, ALA6056L, ALA6071L, ARG4186J, ARG4287J, ARG6064L, ARG6287L, ASN6079L, ASP4182J, ASP4324J, ASP6115L, CYS4285J, CYS6116L, GLN4288J, GLN6288L, GLU4183J, GLU6072L, GLU6114L, GLU6291L, GLU6292L, GLY4181J, GLY4325J, GLY6061L, HIS4184J, HIS4284J, HIS6030L, ILE4323J, LEU4328J, LEU4329J, LEU6060L, LEU6063L, LEU6112L, LYS4275J, LYS4330J, LYS6057L, LYS6078L, LYS6111L, LYS6289L, MET4282J, MET4326J, MET6086L, PHE6076L, PRO4062J, PRO6054L, PRO6058L, PRO6059L, PRO6062L, PRO6073L, PRO6084L, PRO6085L, SER4279J, SER6075L, SER6113L, THR4066J, THR4276J, THR4277J, THR4278J, THR6290L, TRP6074L, TYR6083L, TYR6118L, VAL4281J, VAL4283J, VAL4322J, VAL6077L
• K-L: ALA5056K, ALA5071K, ALA6280L, ARG5064K, ARG5287K, ARG6186L, ARG6287L, ASN5079K, ASP5115K, ASP6182L, ASP6324L, CYS5116K, CYS6285L, GLN5288K, GLN6288L, GLU5072K, GLU5114K, GLU5291K, GLU5292K, GLU6183L, GLY5061K, GLY6181L, GLY6325L, HIS5030K, HIS6184L, HIS6284L, ILE6323L, LEU5060K, LEU5063K, LEU5112K, LEU5295K, LEU6327L, LEU6328L, LEU6329L, LYS5057K, LYS5078K, LYS5111K, LYS5289K, LYS6275L, LYS6330L, MET5086K, MET6282L, MET6326L, PHE5076K, PRO5054K, PRO5058K, PRO5059K, PRO5062K, PRO5073K, PRO5084K, PRO5085K, PRO6062L, SER5075K, SER5113K, SER6279L, THR5290K, THR6276L, THR6277L, THR6278L, THR6331L, TRP5074K, TYR5083K, TYR5118K, VAL6281L, VAL6283L, VAL6322L