1MT5

crystal structure of fatty acid amide hydrolase

• Total interactions analyzed: 120
• Total true interactions: 21
• Strongest Interaction:
  • Chains: G-H
  • Int. Res.: 153
  • Norm. En. per Res.: -3.2265
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-30.4347	20.3029	-444.493	-454.6248	156	8	5	16475	0	29	33
A-D	0.0	0.0	-40.3478	-40.3478	29	0	1	2355	0	2	5
A-H	0.0	0.0	-43.0657	-43.0657	59	3	2	2746	0	16	14
B-C	0.0	0.0	-47.6379	-47.6379	26	2	1	2311	0	2	4
B-K	0.0	-10.3989	-42.7199	-53.1188	72	0	1	2867	0	21	15
C-D	-39.358	23.1575	-453.238	-469.4385	156	13	5	16745	0	28	35
C-J	-3.358	-9.9023	-50.9023	-64.1626	76	2	1	3307	0	25	19
C-K	0.0	0.0	-0.0025	-0.0025	4	0	0	5	0	0	0
D-E	0.0	0.0	-41.4152	-41.4152	55	2	2	2693	0	14	12
E-F	-19.5418	7.9181	-473.344	-484.9677	158	12	5	17191	0	31	35
E-H	0.0	0.0	-50.8546	-50.8546	32	1	2	2632	0	2	6
F-G	0.0	0.0	-38.802	-38.802	25	0	1	2137	0	2	4
F-O	-4.737	-16.1366			4
G-H	-42.3677	11.6195	-462.904	-493.6522	153	13	5	16612	0	29	35
H-L	0.0	0.0	-3.5901	-3.5901	27	0	0	640	0	16	9
I-J	-28.1535	21.2345	-444.917	-451.836	153	6	5	16227	0	28	33
I-L	0.0	0.0	-37.924	-37.924	26	0	1	2139	0	2	4
J-K	0.0	0.0	-45.3897	-45.3897	25	1	1	2277	0	2	4
K-L	-37.5142	16.2588	-456.843	-478.0984	159	11	5	16870	0	27	34
M-N	-32.1809	15.2192			16
O-P	-29.6927	11.4258			16

Interface residues

• A-B: ALA275A, ALA275B, ALA377B, ALA441A, ALA441B, ALA460A, ALA460B, ARG260A, ARG260B, ARG315A, ARG315B, ARG386A, ARG386B, ARG437A, ARG437B, ARG439A, ARG439B, ARG455A, ARG455B, ASN259A, ASN259B, ASN466A, ASP306A, ASP306B, ASP383A, ASP383B, ASP501A, ASP501B, GLN172A, GLN273A, GLN273B, GLN277A, GLN277B, GLN390A, GLN390B, GLN448A, GLN448B, GLN456A, GLN456B, GLN557A, GLN557B, GLU442A, GLU442B, GLU450A, GLU450B, GLU452A, GLU452B, GLU558A, GLU558B, GLU559A, GLU559B, GLY265A, GLY265B, GLY268A, GLY268B, GLY272A, GLY272B, GLY378A, GLY378B, GLY379A, GLY379B, GLY384A, GLY384B, GLY385A, GLY385B, HIS301A, HIS301B, HIS449A, HIS449B, ILE451A, ILE451B, ILE459A, ILE459B, LEU266A, LEU266B, LEU302A, LEU302B, LEU305A, LEU305B, LEU312A, LEU312B, LEU380A, LEU380B, LEU389A, LEU389B, LEU444A, LEU444B, LEU447A, LEU447B, LEU500A, LEU500B, LEU554A, LEU554B, LYS263A, LYS263B, LYS443A, LYS443B, LYS446A, LYS446B, LYS463A, LYS463B, MET453A, MET453B, PHE303A, PHE303B, PHE381A, PHE381B, PHE388A, PHE388B, PHE502A, PHE502B, PRO307A, PRO307B, PRO310A, PRO310B, PRO311A, PRO311B, PRO313A, PRO313B, PRO438A, PRO438B, PRO503B, PRO555A, PRO555B, SER262A, SER262B, SER264A, SER264B, SER382A, SER382B, SER387A, SER387B, SER440A, SER440B, THR257A, THR257B, THR274A, THR274B, THR304A, THR304B, THR308A, THR308B, TRP445A, TRP445B, TRP462A, TRP462B, TRP556A, TRP556B, TYR271A, TYR271B, VAL169A, VAL169B, VAL270A, VAL270B, VAL309A, VAL309B
• A-D: ALA37A, ARG409A, ARG416D, ASN367D, ASP403A, ILE405A, ILE407A, LEU389A, LEU406A, LEU408A, LEU410A, LEU417A, LEU417D, LEU418A, LEU418D, LEU420D, LEU421D, LEU422D, LEU425D, LYS415A, LYS423D, PHE414A, PHE414D, PRO411A, PRO424D, SER419D, TRP413A, TRP413D, VAL397A
• A-H: ALA518H, ARG343A, ARG428A, ARG486H, ASN334A, ASN366A, ASN367A, ASN541H, ASP333A, ASP403H, ASP529A, ASP529H, ASP532H, GLU331A, GLU521H, GLY525A, GLY525H, GLY528A, GLY528H, ILE407H, ILE530H, ILE533A, ILE533H, ILE534H, LEU364A, LEU406H, LEU410H, LEU418H, LEU420A, LEU421A, LEU421H, LEU422A, LEU422H, LEU425A, LEU425H, LEU429H, LEU433H, LEU522H, LYS423A, LYS524A, LYS524H, LYS536H, LYS537H, MET337A, MET520H, PHE414H, PHE426A, PHE426H, PHE527A, PHE527H, PRO362A, PRO369A, PRO424A, PRO427A, THR332A, TRP531H, TYR335A, TYR523H, TYR526A
• B-C: ARG409C, ARG416B, ASP403C, ILE407C, LEU406C, LEU408C, LEU410C, LEU417B, LEU417C, LEU418B, LEU418C, LEU420B, LEU421B, LEU422B, LEU425B, LYS415B, LYS415C, LYS423B, PHE414B, PHE414C, PRO411C, PRO424B, SER412C, TRP413B, TRP413C, VAL397C
• B-K: ALA37B, ALA40B, ALA41B, ALA518K, ARG343K, ARG409B, ARG43B, ARG45B, ARG486B, ASN334K, ASN366K, ASN482B, ASN541B, ASP333K, ASP398B, ASP403B, ASP480B, CYS400B, GLN203B, GLN46B, GLN519K, GLU331K, GLU515K, GLU521K, GLY202B, GLY39B, GLY402B, GLY525K, GLY528K, ILE347K, ILE368K, ILE407B, ILE533K, LEU364K, LEU406B, LEU410B, LEU418B, LEU421K, LEU422K, LEU425K, LEU481B, LEU522K, LYS212B, LYS423K, LYS524K, LYS536K, LYS537B, MET337K, PHE363K, PHE396B, PHE414B, PHE426K, PHE527K, PRO199B, PRO362K, PRO369K, PRO399B, PRO411B, PRO424K, PRO427K, SER210B, SER211B, THR332K, THR42B, THR483B, TRP413B, TYR329K, TYR330K, TYR335K, TYR523K, TYR526K, VAL397B
• C-D: ALA275C, ALA275D, ALA377D, ALA441C, ALA441D, ALA460C, ALA460D, ALA553D, ARG260C, ARG260D, ARG315C, ARG315D, ARG386C, ARG386D, ARG437C, ARG437D, ARG439C, ARG439D, ARG455C, ARG455D, ASN259C, ASN259D, ASN466C, ASN466D, ASP306C, ASP306D, ASP383C, ASP383D, ASP501C, ASP501D, GLN172C, GLN172D, GLN273C, GLN273D, GLN277C, GLN277D, GLN390C, GLN390D, GLN448C, GLN448D, GLN456C, GLN456D, GLN557C, GLN557D, GLU442C, GLU442D, GLU450C, GLU450D, GLU452C, GLU452D, GLU558C, GLU558D, GLU559C, GLU559D, GLY265C, GLY265D, GLY268C, GLY272C, GLY272D, GLY378C, GLY378D, GLY379C, GLY379D, GLY384C, GLY384D, GLY385C, GLY385D, HIS301C, HIS301D, HIS449C, HIS449D, ILE451C, ILE451D, ILE459C, ILE459D, LEU266C, LEU266D, LEU302C, LEU305C, LEU305D, LEU312C, LEU312D, LEU380C, LEU380D, LEU389C, LEU444C, LEU444D, LEU447C, LEU447D, LEU500C, LEU500D, LEU554C, LEU554D, LYS263C, LYS263D, LYS443C, LYS443D, LYS446C, LYS446D, LYS463C, LYS463D, MET453C, MET453D, PHE303C, PHE303D, PHE381C, PHE381D, PHE388C, PHE388D, PHE502C, PHE502D, PRO307C, PRO307D, PRO310C, PRO310D, PRO311C, PRO311D, PRO313C, PRO313D, PRO438C, PRO438D, PRO503D, PRO555C, PRO555D, SER262C, SER262D, SER264C, SER264D, SER382C, SER382D, SER387C, SER387D, SER440C, SER440D, THR257C, THR257D, THR274C, THR274D, THR304C, THR304D, THR308C, THR308D, TRP445C, TRP445D, TRP462C, TRP462D, TRP556C, TRP556D, TYR271C, TYR271D, VAL169C, VAL169D, VAL270C, VAL270D, VAL309C, VAL309D
• C-J: ALA37J, ALA40J, ALA41J, ALA518C, ARG343C, ARG409J, ARG43J, ARG45J, ARG486J, ARG49J, ASN334C, ASN482J, ASP333C, ASP398J, ASP403J, ASP480J, ASP529C, ASP532C, CYS400J, GLN203J, GLN46J, GLN519C, GLU331C, GLU515C, GLU521C, GLY202J, GLY39J, GLY402J, GLY525C, GLY528C, ILE347C, ILE407J, ILE533C, LEU364C, LEU401J, LEU406J, LEU410J, LEU418J, LEU421C, LEU425C, LEU481J, LEU522C, LYS209J, LYS212J, LYS350C, LYS423C, LYS524C, LYS536C, MET205J, MET337C, PHE363C, PHE396J, PHE414J, PHE426C, PHE527C, PRO199J, PRO338C, PRO362C, PRO369C, PRO399J, PRO411J, PRO424C, PRO427C, SER197J, SER210J, SER211J, THR332C, THR42J, THR483J, TRP413J, TYR329C, TYR330C, TYR335C, TYR523C, TYR526C, VAL397J
• C-K: LEU417C, LEU417K, LEU421C, LEU421K
• D-E: ALA430D, ALA518D, ARG343E, ARG428E, ARG486D, ASN334E, ASN366E, ASN367E, ASN541D, ASP333E, ASP403D, ASP529D, ASP529E, GLU521D, GLY525E, GLY528D, GLY528E, ILE407D, ILE530D, ILE533D, ILE533E, ILE534D, LEU364E, LEU406D, LEU418D, LEU420E, LEU421E, LEU422D, LEU422E, LEU425D, LEU425E, LEU429D, LEU433D, LEU522D, LYS423E, LYS524D, LYS524E, LYS536D, LYS537D, MET337E, MET520D, PHE414D, PHE426D, PHE426E, PHE527D, PHE527E, PRO362E, PRO369E, PRO424E, PRO427E, THR332E, TRP531D, TYR335E, TYR523D, TYR526E
• E-F: ALA275E, ALA275F, ALA441E, ALA441F, ALA460E, ALA460F, ALA553E, ARG260E, ARG260F, ARG315E, ARG315F, ARG386E, ARG386F, ARG437E, ARG437F, ARG439E, ARG439F, ARG455E, ARG455F, ASN259E, ASN259F, ASN466E, ASP306E, ASP306F, ASP383E, ASP383F, ASP501E, ASP501F, CYS269E, GLN172E, GLN172F, GLN273E, GLN273F, GLN277E, GLN277F, GLN390E, GLN390F, GLN448E, GLN448F, GLN456E, GLN456F, GLN557E, GLN557F, GLU442E, GLU442F, GLU450E, GLU450F, GLU452E, GLU452F, GLU558E, GLU558F, GLU559E, GLU559F, GLY265E, GLY265F, GLY268E, GLY268F, GLY272E, GLY272F, GLY378E, GLY378F, GLY379E, GLY379F, GLY384E, GLY384F, GLY385E, GLY385F, HIS301E, HIS301F, HIS449E, HIS449F, ILE451E, ILE451F, ILE459E, ILE459F, LEU266E, LEU266F, LEU302E, LEU302F, LEU305E, LEU305F, LEU312E, LEU312F, LEU380E, LEU380F, LEU389E, LEU389F, LEU444E, LEU444F, LEU447E, LEU447F, LEU500E, LEU500F, LEU554E, LEU554F, LYS263E, LYS263F, LYS443E, LYS443F, LYS446E, LYS446F, LYS463E, LYS463F, MET453E, MET453F, PHE303E, PHE303F, PHE381E, PHE381F, PHE388E, PHE388F, PHE502E, PHE502F, PRO307E, PRO307F, PRO310E, PRO310F, PRO311E, PRO311F, PRO313E, PRO313F, PRO438E, PRO438F, PRO503E, PRO555E, PRO555F, SER262E, SER262F, SER264E, SER264F, SER382E, SER382F, SER387E, SER387F, SER440E, SER440F, THR257E, THR257F, THR274E, THR274F, THR304E, THR304F, THR308E, THR308F, TRP445E, TRP445F, TRP462E, TRP462F, TRP556E, TRP556F, TYR271E, TYR271F, VAL169E, VAL169F, VAL270E, VAL270F, VAL309E, VAL309F
• E-H: ALA37E, ARG409E, ARG416H, ASN367H, ASP403E, GLY402E, ILE405E, ILE407E, LEU389E, LEU406E, LEU408E, LEU410E, LEU417E, LEU417H, LEU418E, LEU418H, LEU420H, LEU421H, LEU422H, LEU425H, LYS415E, LYS415H, LYS423H, PHE414E, PHE414H, PRO411E, PRO424H, SER412E, SER419H, TRP413E, TRP413H, VAL397E
• F-G: ARG409G, ARG416F, ILE405G, ILE407G, LEU389G, LEU406G, LEU408G, LEU410G, LEU417F, LEU417G, LEU418F, LEU418G, LEU420F, LEU421F, LEU422F, LEU425F, LYS415G, LYS423F, PHE414F, PHE414G, PRO411G, PRO424F, TRP413F, TRP413G, VAL397G
• F-O: ARG45F, ASN482F, GLU331O, LEU522O
• G-H: ALA275G, ALA275H, ALA377G, ALA441G, ALA441H, ALA460G, ALA460H, ARG260G, ARG260H, ARG315G, ARG315H, ARG386G, ARG386H, ARG437G, ARG437H, ARG439G, ARG439H, ARG455G, ARG455H, ASN259G, ASN259H, ASN466G, ASN466H, ASP306G, ASP306H, ASP383G, ASP383H, ASP501G, ASP501H, CYS269H, GLN172G, GLN273G, GLN273H, GLN277H, GLN390G, GLN390H, GLN448G, GLN448H, GLN456G, GLN456H, GLN557G, GLN557H, GLU442G, GLU442H, GLU450G, GLU450H, GLU452G, GLU452H, GLU558G, GLU559G, GLU559H, GLY265G, GLY265H, GLY268G, GLY272G, GLY272H, GLY378G, GLY378H, GLY379G, GLY379H, GLY384G, GLY384H, GLY385G, GLY385H, HIS301G, HIS301H, HIS449G, HIS449H, ILE451G, ILE451H, ILE459G, ILE459H, LEU266G, LEU266H, LEU302H, LEU305G, LEU305H, LEU312G, LEU312H, LEU380G, LEU380H, LEU389H, LEU444G, LEU444H, LEU447G, LEU447H, LEU500G, LEU500H, LEU554G, LEU554H, LYS263G, LYS263H, LYS443G, LYS443H, LYS446G, LYS446H, LYS463G, LYS463H, MET453G, MET453H, PHE303G, PHE303H, PHE381G, PHE381H, PHE388G, PHE388H, PHE502G, PHE502H, PRO307G, PRO307H, PRO310G, PRO310H, PRO311G, PRO311H, PRO313G, PRO313H, PRO438G, PRO438H, PRO503H, PRO555G, PRO555H, SER262G, SER262H, SER264G, SER264H, SER382G, SER382H, SER387G, SER387H, SER440G, SER440H, THR257G, THR257H, THR274G, THR274H, THR304G, THR304H, THR308G, THR308H, TRP445G, TRP445H, TRP462G, TRP462H, TRP556G, TRP556H, TYR271G, TYR271H, VAL169G, VAL169H, VAL270G, VAL270H, VAL309G, VAL309H
• H-L: ALA40L, ALA50L, ARG43H, ARG43L, ASP120H, ASP120L, CYS121H, CYS121L, GLN46H, GLN46L, GLU122H, GLU122L, GLU165H, GLU165L, GLY161H, GLY161L, LYS47H, LYS47L, MET162H, MET162L, PRO163H, PRO163L, SER126L, SER164H, THR119H, THR123H, THR123L
• I-J: ALA275I, ALA275J, ALA377I, ALA377J, ALA441I, ALA441J, ALA460I, ALA460J, ARG260I, ARG260J, ARG315I, ARG315J, ARG386I, ARG386J, ARG437I, ARG437J, ARG439I, ARG439J, ARG455I, ARG455J, ASN259I, ASN259J, ASN466I, ASP306I, ASP306J, ASP383I, ASP383J, ASP501I, ASP501J, GLN273I, GLN273J, GLN277I, GLN277J, GLN390I, GLN390J, GLN448I, GLN448J, GLN456I, GLN456J, GLN557I, GLN557J, GLU442I, GLU442J, GLU450I, GLU450J, GLU452I, GLU452J, GLU558I, GLU559I, GLU559J, GLY265I, GLY265J, GLY268I, GLY268J, GLY272I, GLY272J, GLY378I, GLY378J, GLY379I, GLY379J, GLY384I, GLY384J, GLY385I, GLY385J, HIS301I, HIS301J, HIS449I, HIS449J, ILE451I, ILE451J, ILE459I, ILE459J, LEU266I, LEU266J, LEU302I, LEU302J, LEU305I, LEU305J, LEU312I, LEU312J, LEU380I, LEU380J, LEU389J, LEU444I, LEU444J, LEU447I, LEU447J, LEU500I, LEU500J, LEU554I, LEU554J, LYS263I, LYS263J, LYS443I, LYS443J, LYS446I, LYS446J, LYS463I, LYS463J, MET453I, MET453J, PHE303I, PHE303J, PHE381I, PHE381J, PHE388I, PHE388J, PHE502I, PHE502J, PRO307I, PRO307J, PRO310I, PRO310J, PRO311I, PRO311J, PRO313I, PRO313J, PRO438I, PRO438J, PRO555I, PRO555J, SER262I, SER262J, SER264I, SER264J, SER382I, SER382J, SER387I, SER387J, SER440I, SER440J, THR257I, THR257J, THR274I, THR274J, THR304I, THR304J, THR308I, THR308J, TRP445I, TRP445J, TRP462I, TRP462J, TRP556I, TRP556J, TYR271I, TYR271J, VAL169I, VAL169J, VAL270I, VAL270J, VAL309I, VAL309J
• I-L: ARG409I, ARG416L, ASP403I, ILE407I, LEU406I, LEU408I, LEU410I, LEU417I, LEU417L, LEU418I, LEU418L, LEU420L, LEU421L, LEU422L, LEU425L, LYS415I, LYS415L, LYS423L, PHE414I, PHE414L, PRO411I, PRO424L, SER419L, TRP413I, TRP413L, VAL397I
• J-K: ARG409K, ARG416J, ASP403K, ILE407K, LEU406K, LEU408K, LEU410K, LEU417J, LEU417K, LEU418J, LEU418K, LEU420J, LEU421J, LEU422J, LEU425J, LYS415J, LYS415K, LYS423J, PHE414J, PHE414K, PRO411K, PRO424J, TRP413J, TRP413K, VAL397K
• K-L: ALA275K, ALA275L, ALA377K, ALA377L, ALA441K, ALA441L, ALA460K, ALA460L, ALA553K, ALA553L, ARG260K, ARG260L, ARG315K, ARG315L, ARG386K, ARG386L, ARG437K, ARG437L, ARG439K, ARG439L, ARG455K, ARG455L, ASN259K, ASN259L, ASN466K, ASN466L, ASP306K, ASP306L, ASP383K, ASP383L, ASP501K, ASP501L, GLN172K, GLN172L, GLN273K, GLN273L, GLN277K, GLN277L, GLN390K, GLN390L, GLN448K, GLN448L, GLN456K, GLN456L, GLN557K, GLN557L, GLU300L, GLU442K, GLU442L, GLU450K, GLU450L, GLU452K, GLU452L, GLU558K, GLU558L, GLU559K, GLU559L, GLY265K, GLY265L, GLY268K, GLY272K, GLY272L, GLY378K, GLY378L, GLY379K, GLY379L, GLY384K, GLY384L, GLY385K, GLY385L, HIS301K, HIS301L, HIS449K, HIS449L, ILE451K, ILE451L, ILE459K, ILE459L, LEU266K, LEU266L, LEU302K, LEU302L, LEU305K, LEU305L, LEU312K, LEU312L, LEU380K, LEU380L, LEU444K, LEU444L, LEU447K, LEU447L, LEU500K, LEU500L, LEU554K, LEU554L, LYS263K, LYS263L, LYS443K, LYS443L, LYS446K, LYS446L, LYS463K, LYS463L, MET453K, MET453L, PHE303K, PHE303L, PHE381K, PHE381L, PHE388K, PHE388L, PHE502K, PHE502L, PRO307K, PRO307L, PRO310K, PRO310L, PRO311K, PRO311L, PRO313K, PRO313L, PRO438K, PRO438L, PRO503L, PRO555K, PRO555L, SER262K, SER262L, SER264K, SER264L, SER382K, SER382L, SER387K, SER387L, SER440K, SER440L, THR257K, THR257L, THR274K, THR274L, THR304K, THR304L, THR308K, THR308L, TRP445K, TRP445L, TRP462K, TRP462L, TRP556K, TRP556L, TYR271K, TYR271L, VAL169K, VAL169L, VAL270K, VAL270L, VAL309K, VAL309L
• M-N: ALA441M, ALA441N, ARG439M, ARG439N, ARG455N, ASP306M, ASP383M, ASP383N, GLN448N, GLN456M, GLU442M, GLU442N, GLU452M, LYS263N, SER264N, THR274M
• O-P: ALA441O, ALA441P, ARG439O, ARG439P, ARG455O, ASP306P, ASP383O, ASP383P, GLN448O, GLU442O, GLU442P, GLU452O, LYS263P, LYS463O, THR274P, THR304P