1MOX

crystal structure of human epidermal growth factor receptor (residues 1-501) in complex with tgf-alpha

• Total interactions analyzed: 6
• Total true interactions: 3
• Strongest Interaction:
  • Chains: B-D
  • Int. Res.: 134
  • Norm. En. per Res.: -3.4905
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-28.6582	13.6826	-305.648	-320.6236	141	21	2	11444	0	25	23
A-C	-87.7109	-38.2609	-343.293	-469.2648	142	28	9	14979	8	27	31
B-D	-71.6216	-48.3991	-347.707	-467.7277	134	26	9	14914	7	28	31

Interface residues

• A-B: ALA192A, ALA192B, ALA265A, ALA265B, ALA286A, ALA286B, ALA62A, ALA62B, ARG228A, ARG228B, ARG231A, ARG231B, ARG285A, ARG285B, ARG405A, ARG405B, ARG84A, ARG84B, ASN247A, ASN247B, ASN314A, ASN86A, ASN86B, ASP206A, ASP206B, ASP238A, ASP238B, ASP254A, ASP254B, ASP279A, ASP279B, CYS195A, CYS195B, CYS207A, CYS207B, CYS240A, CYS240B, CYS267A, CYS267B, CYS271A, CYS271B, CYS283A, CYS283B, CYS287A, CYS287B, CYS302B, CYS305A, GLN193A, GLN193B, GLN194A, GLN194B, GLN252A, GLN252B, GLU296B, GLY264A, GLY264B, GLY281A, GLY281B, GLY288A, GLY288B, GLY319A, GLY319B, HIS121B, HIS280A, HIS280B, ILE318A, ILE318B, LEU243A, LEU243B, LEU245A, LEU245B, LEU38A, LEU38B, LYS229A, LYS229B, LYS301B, LYS303A, LYS304A, LYS304B, LYS322A, MET244A, MET244B, MET253A, MET253B, MET294A, MET294B, MET87A, MET87B, PHE230A, PHE230B, PHE263A, PHE263B, PRO204A, PRO204B, PRO219A, PRO219B, PRO241A, PRO242A, PRO242B, PRO248A, PRO248B, PRO272A, PRO272B, SER203A, SER203B, SER205A, SER205B, SER262A, SER262B, SER282A, SER282B, SER342A, SER342B, THR239A, THR239B, THR249A, THR249B, THR250A, THR250B, THR266A, THR266B, THR278A, THR278B, THR406A, THR406B, TYR246A, TYR246B, TYR251A, TYR251B, TYR261A, TYR261B, TYR275A, TYR275B, VAL255A, VAL268A, VAL268B, VAL276A, VAL276B, VAL284A, VAL284B, VAL6A
• A-C: ALA103A, ALA31C, ALA351A, ALA385A, ALA415A, ALA41C, ALA46C, ALA50C, ALA68A, ALA96A, ARG125A, ARG22C, ARG29A, ARG353A, ARG42C, ASN100A, ASN104A, ASN128A, ASN129A, ASN12A, ASN70A, ASP102A, ASP10C, ASP22A, ASP28C, ASP323A, ASP355A, ASP436A, ASP47C, CYS16C, CYS21C, CYS32C, CYS34C, CYS43C, CYS8C, GLN14C, GLN16A, GLN26C, GLN384A, GLN408A, GLN411A, GLN47A, GLN8A, GLU27C, GLU42A, GLU44C, GLU90A, GLY107A, GLY18A, GLY19C, GLY354A, GLY37C, GLY40C, GLY410A, HIS12C, HIS18C, HIS23A, HIS346A, HIS359A, HIS35C, HIS409A, HIS45C, HIS4C, ILE316A, ILE347A, ILE383A, ILE438A, ILE439A, ILE467A, LEU14A, LEU17A, LEU24C, LEU325A, LEU348A, LEU381A, LEU382A, LEU414A, LEU48C, LEU49C, LEU66A, LEU69A, LEU98A, LYS105A, LYS13A, LYS29C, LYS407A, LYS463A, LYS465A, MET30A, PHE15C, PHE17C, PHE20A, PHE23C, PHE357A, PHE380A, PHE412A, PHE5C, PRO130A, PRO30C, PRO349A, PRO361A, PRO362A, PRO9C, SER11A, SER11C, SER127A, SER26A, SER324A, SER326A, SER356A, SER36C, SER3C, SER413A, SER418A, SER440A, SER468A, SER99A, THR106A, THR10A, THR13C, THR15A, THR19A, THR20C, THR358A, THR360A, THR44A, THR71A, TYR101A, TYR38C, TYR45A, TYR64A, TYR89A, TYR93A, VAL25C, VAL2C, VAL33C, VAL350A, VAL39C, VAL416A, VAL417A, VAL437A, VAL97A
• B-D: ALA103B, ALA31D, ALA351B, ALA385B, ALA415B, ALA41D, ALA46D, ALA50D, ALA68B, ALA96B, ARG125B, ARG22D, ARG29B, ARG353B, ARG42D, ASN100B, ASN104B, ASN128B, ASN129B, ASN12B, ASN70B, ASP102B, ASP10D, ASP22B, ASP28D, ASP355B, ASP436B, ASP47D, CYS16D, CYS21D, CYS32D, CYS34D, CYS43D, GLN14D, GLN16B, GLN26D, GLN384B, GLN408B, GLN411B, GLN47B, GLN8B, GLU27D, GLU42B, GLU44D, GLU90B, GLY107B, GLY18B, GLY19D, GLY354B, GLY37D, GLY40D, GLY410B, GLY441B, HIS12D, HIS18D, HIS23B, HIS346B, HIS359B, HIS35D, HIS409B, HIS45D, HIS4D, ILE316B, ILE383B, ILE438B, ILE439B, ILE467B, LEU14B, LEU17B, LEU24D, LEU325B, LEU348B, LEU381B, LEU382B, LEU414B, LEU48D, LEU49D, LEU66B, LEU69B, LEU98B, LYS105B, LYS13B, LYS29D, LYS407B, LYS463B, LYS465B, MET30B, PHE15D, PHE17D, PHE20B, PHE357B, PHE380B, PHE412B, PHE5D, PRO130B, PRO30D, PRO349B, PRO9D, SER11B, SER11D, SER127B, SER26B, SER324B, SER326B, SER356B, SER36D, SER3D, SER413B, SER418B, SER440B, SER468B, SER99B, THR106B, THR10B, THR13D, THR15B, THR19B, THR20D, THR358B, THR360B, THR71B, TYR101B, TYR38D, TYR45B, TYR64B, TYR89B, VAL25D, VAL33D, VAL350B, VAL39D, VAL416B, VAL417B, VAL437B, VAL97B