1MNF

domain motions in groel upon binding of an oligopeptide

• Total interactions analyzed: 378
• Total true interactions: 82
• Strongest Interaction:
  • Chains: L-Z
  • Int. Res.: 43
  • Norm. En. per Res.: -4.2755
• Hub Node: A(7)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-O	-15.3577	9.7524	-171.467	-177.0723	43	8	5	6227	0	5	2
A-B	-99.4301	-80.1886	-383.112	-562.7308	178	31	7	16162	8	82	76
A-P	-3.6842	2.7071	-14.8916	-15.8686	10	0	0	686	0	0	1
A-G	-120.3167	-82.8437	-398.268	-601.4284	178	34	10	16949	11	85	81
A-U	-2.5885	0.0	-9.9017	-12.4902	8	2	0	401	0	0	0
A-L	-14.2445	3.1996	-34.3855	-45.4304	22	4	1	1439	0	6	5
A-M	0.0	28.7242	-19.5744	9.1498	24	1	6	1243	0	4	3
O-B	-4.5812	0.0	-12.2413	-16.8225	8	0	0	410	0	0	0
O-P	0.0	0.0	-5.5873	-5.5873	12	0	0	367	0	0	0
O-G	-8.4553	2.5494	-18.9104	-24.8163	11	1	0	799	0	0	1
O-U	0.0	0.0	-8.1382	-8.1382	12	0	0	452	0	0	0
B-P	-18.6069	10.0396	-169.416	-177.9834	43	11	5	6138	0	5	2
B-C	-129.0502	-84.3311	-392.718	-606.0993	179	36	9	17021	11	85	81
B-Q	-7.285	2.6779	-17.2865	-21.8936	10	1	0	768	0	0	1
B-D	0.0	0.0	-0.0006	-0.0006	2	0	0	2	0	0	0
B-K	-16.0706	3.3491	-31.3748	-44.0962	22	1	1	1357	0	6	5
B-L	0.0	23.9781	-20.9088	3.0693	30	1	4	1396	0	15	10
P-C	-2.377	0.0	-6.2955	-8.6726	8	2	0	411	0	0	0
P-Q	0.0	0.0	-7.5297	-7.5297	12	0	0	440	0	0	0
C-Q	-20.2878	9.9171	-167.998	-178.3687	43	11	5	6222	0	5	2
C-D	-109.6669	-82.3946	-384.497	-576.5585	173	31	8	16036	8	81	76
C-R	0.0	2.565	-13.7726	-11.2076	10	0	0	656	0	0	1
C-J	-14.1844	2.1695	-36.7194	-48.7344	23	4	1	1491	0	6	5
C-K	0.0	29.597	-25.742	3.855	30	2	6	1582	0	16	11
Q-D	-6.1601	0.0	-10.7171	-16.8772	8	1	0	419	0	0	0
Q-R	0.0	0.0	-5.4768	-5.4768	12	0	0	366	0	0	0
D-R	-18.3998	9.255	-168.309	-177.4538	43	12	5	6224	0	5	2
D-E	-112.7342	-84.0105	-403.943	-600.6877	182	38	8	17194	11	86	82
D-S	-6.6149	2.6042	-16.6895	-20.7002	10	0	0	745	0	0	1
D-I	-14.3274	3.1923	-34.5938	-45.7288	22	3	1	1438	0	6	5
D-J	0.0	27.4403	-20.6898	6.7505	30	1	4	1374	0	14	9
R-E	-3.516	0.0	-12.3999	-15.9159	9	2	0	420	0	0	0
R-S	0.0	0.0	-6.8198	-6.8198	12	0	0	413	0	0	0
E-S	-19.5101	9.6557	-168.837	-178.6914	43	12	5	6178	0	5	2
E-F	-116.2028	-83.2959	-379.356	-578.8546	178	34	10	16604	10	83	82
E-T	0.0	2.5671	-15.1957	-12.6286	10	0	0	690	0	0	1
E-H	-18.7133	3.2505	-37.7328	-53.1956	23	5	1	1582	1	6	5
E-I	0.0	26.7306	-24.0278	2.7028	30	1	4	1545	0	18	11
S-F	-3.3448	0.0	-11.2155	-14.5603	8	2	0	421	0	0	0
S-T	0.0	0.0	-6.1109	-6.1109	12	0	0	391	0	0	0
F-T	-20.8282	9.3463	-163.215	-174.6968	43	11	5	6087	0	5	2
F-G	-96.6639	-79.198	-367.918	-543.7799	175	30	7	15979	8	81	79
F-U	-3.7487	2.6224	-14.0122	-15.1385	10	0	0	665	0	0	1
F-H	0.0	27.7992	-24.4555	3.3437	30	1	5	1540	0	16	11
F-N	-13.2109	1.1787			3
T-G	-4.171	0.0	-13.1047	-17.2757	9	1	0	459	0	0	0
T-U	0.0	0.0	-6.1627	-6.1627	12	1	0	394	0	0	0
G-U	-18.4685	10.0537	-173.958	-182.3728	43	14	5	6284	0	5	2
G-M	-14.5493	3.2476	0.0	-11.3017	3	0	0	0	0	0	0
G-N	0.0	27.4289			4
H-V	-21.7315	9.9807	-167.126	-178.8768	43	15	5	6162	0	5	2
H-I	-127.996	-81.7885	-390.623	-600.4075	181	38	8	16857	10	86	83
H-W	0.0	2.5846	-17.9296	-15.345	10	0	0	750	0	0	1
H-N	-114.1317	-84.0257			40
H-2	-4.424	0.0			2
V-I	-3.694	0.0	-12.3661	-16.0601	8	1	0	390	0	0	0
V-W	0.0	0.0	-7.2868	-7.2868	12	1	0	460	0	0	0
V-N	0.0	2.6791			2
I-W	-26.6982	10.1409	-154.437	-170.9943	43	11	5	6157	0	5	2
I-J	-104.4707	-80.1179	-379.93	-564.5185	179	32	8	16263	8	83	80
I-X	0.0	2.6001	-16.5195	-13.9194	10	0	0	711	0	0	1
W-J	-4.8249	0.0	-10.3918	-15.2167	8	1	0	415	0	0	0
W-X	0.0	0.0	-7.056	-7.056	12	1	0	438	0	0	0
J-X	-21.3215	9.8267	-161.709	-173.2038	43	9	5	6088	0	5	2
J-K	-110.399	-83.7512	-386.922	-581.0722	177	33	8	16367	9	83	77
J-Y	0.0	2.5776	-14.6011	-12.0235	10	0	0	670	0	0	1
X-K	-4.1375	0.0	-12.0129	-16.1504	8	0	0	384	0	0	0
X-Y	0.0	0.0	-5.5893	-5.5893	12	0	0	379	0	0	0
K-Y	-19.8783	9.196	-161.024	-171.7063	43	13	5	6107	0	5	2
K-L	-103.5373	-81.4308	-354.629	-539.597	174	27	9	15663	9	81	75
K-Z	-11.595	2.6366	-13.8897	-22.8481	10	0	0	694	0	0	1
Y-L	-4.158	0.0	-12.3258	-16.4838	8	3	0	425	0	0	0
Y-Z	0.0	0.0	-6.3758	-6.3758	12	0	0	392	0	0	0
L-Z	-16.784	9.3246	-176.385	-183.8444	43	16	5	6435	0	5	2
L-M	-110.6229	-82.9845	-150.483	-344.0904	118	9	3	6539	7	31	41
L-1	-6.1943	2.5938			3
Z-M	-3.0532	0.0	0.0	-3.0532	2	0	0	0	0	0	0
M-1	-20.4411	9.7549			6
M-N	-106.2288	-80.9706			37
M-2	-9.5771	2.729			4
1-N	-4.2017	0.0			2
N-2	-20.9379	10.1628			6

Interface residues

• A-O: ALA239A, ALA241A, ALA258A, ALA260A, ARG231A, ARG268A, ASN229A, ASN265A, GLU238A, GLU257A, GLY256A, GLY608O, HIS611O, ILE230A, ILE270A, LEU234A, LEU237A, LEU247A, LEU259A, LEU262A, LEU610O, LYS242A, LYS272A, MET233A, MET603O, PHE609O, PRO235A, PRO606O, PRO612O, SER228A, SER601O, THR261A, THR266A, THR604O, THR605O, TRP602O, TRP607O, VAL236A, VAL240A, VAL263A, VAL264A, VAL271A, VAL273A
• A-B: ALA12B, ALA241A, ALA243A, ALA24A, ALA258B, ALA26A, ALA278B, ALA2B, ALA383A, ALA384A, ALA3B, ALA46A, ALA480A, ALA481A, ALA57A, ALA71B, ARG118B, ARG13B, ARG197B, ARG231B, ARG268A, ARG284B, ARG285B, ARG36A, ARG58A, ASN112B, ASN206A, ASN21A, ASN229B, ASN265A, ASN37A, ASN433B, ASN457A, ASN68A, ASN68B, ASP115B, ASP179A, ASP253B, ASP25A, ASP283B, ASP359B, ASP361B, ASP41A, ASP435B, ASP523B, ASP5B, ASP64A, CYS458A, CYS519B, GLN184A, GLN432B, GLN436B, GLN72A, GLN72B, GLU186A, GLU214A, GLU216A, GLU232B, GLU252B, GLU255B, GLU257B, GLU303B, GLU308B, GLU310B, GLU386A, GLU388A, GLU460A, GLU483A, GLU518B, GLU59A, GLU61A, GLU63A, GLU76B, GLY180A, GLY182A, GLY244A, GLY256B, GLY269A, GLY280B, GLY282B, GLY32A, GLY35A, GLY382A, GLY459A, GLY45A, GLY512B, GLY70B, GLY9B, ILE227B, ILE230B, ILE270A, ILE49A, ILE515B, ILE60A, LEU116B, LEU183A, LEU215A, LEU23A, LEU40A, LEU456A, LEU513B, LEU524B, LEU62A, LYS117B, LYS207A, LYS225B, LYS226B, LYS242A, LYS245A, LYS272A, LYS277B, LYS286B, LYS28A, LYS34A, LYS364B, LYS390A, LYS42A, LYS4B, LYS51A, LYS526B, LYS65A, LYS65B, LYS75A, LYS75B, LYS7B, LYS80B, MET111B, MET114B, MET16B, MET267A, MET389A, MET514B, MET520B, MET69B, MET73B, PHE281B, PHE66B, PHE8B, PRO113B, PRO33A, PRO47A, PRO525B, SER217A, SER228B, SER358B, SER43A, SER509B, SER55A, THR181A, THR261B, THR266A, THR30A, THR357B, THR385A, THR482A, THR48A, THR50A, THR516B, THR517B, THR522B, TYR360B, VAL107B, VAL22A, VAL264A, VAL271A, VAL27A, VAL29A, VAL381A, VAL387A, VAL38A, VAL39A, VAL455A, VAL510B, VAL521B, VAL56A, VAL6B, VAL74B, VAL77B
• A-P: ARG268A, ASN265A, GLY269A, HIS611P, ILE270A, MET267A, MET603P, PRO612P, SER601P, TRP602P
• A-G: ALA12A, ALA241G, ALA243G, ALA24G, ALA258A, ALA26G, ALA278A, ALA2A, ALA383G, ALA384G, ALA3A, ALA46G, ALA480G, ALA481G, ALA57G, ALA71A, ARG118A, ARG13A, ARG197A, ARG231A, ARG268G, ARG284A, ARG285A, ARG322G, ARG36G, ARG58G, ASN112A, ASN206G, ASN21G, ASN229A, ASN265G, ASN37G, ASN433A, ASN457G, ASN68A, ASN68G, ASP115A, ASP179G, ASP253A, ASP25G, ASP283A, ASP361A, ASP41G, ASP435A, ASP523A, ASP5A, ASP64G, CYS458G, CYS519A, GLN184G, GLN432A, GLN436A, GLN72A, GLN72G, GLU186G, GLU214G, GLU216G, GLU232A, GLU252A, GLU255A, GLU257A, GLU303A, GLU308A, GLU310A, GLU386G, GLU388G, GLU460G, GLU483G, GLU518A, GLU59G, GLU61A, GLU61G, GLU63G, GLU76A, GLY180G, GLY182G, GLY244G, GLY256A, GLY269G, GLY280A, GLY282A, GLY32G, GLY35G, GLY382G, GLY459G, GLY45G, GLY512A, GLY70A, GLY9A, ILE227A, ILE230A, ILE270G, ILE49G, ILE515A, ILE60G, LEU183G, LEU23G, LEU40G, LEU456G, LEU513A, LEU524A, LEU62G, LYS117A, LYS207G, LYS225A, LYS226A, LYS242G, LYS245G, LYS272G, LYS277A, LYS286A, LYS28G, LYS34G, LYS364A, LYS390G, LYS42G, LYS4A, LYS51G, LYS526A, LYS65A, LYS65G, LYS75A, LYS75G, LYS7A, LYS80A, MET111A, MET114A, MET16A, MET267G, MET389G, MET514A, MET520A, MET69A, MET73A, PHE281A, PHE66A, PHE8A, PRO113A, PRO279A, PRO33G, PRO47G, PRO525A, SER217G, SER228A, SER358A, SER43G, SER509A, SER55G, THR181G, THR261A, THR266G, THR30G, THR357A, THR385G, THR482G, THR48G, THR50G, THR516A, THR517A, THR522A, TYR360A, VAL107A, VAL22G, VAL264G, VAL271G, VAL27G, VAL29G, VAL381G, VAL387G, VAL38G, VAL39G, VAL455G, VAL510A, VAL521A, VAL56G, VAL6A, VAL74A, VAL77A
• A-U: ARG231A, ASN229A, GLY608U, PHE609U, PRO606U, THR604U, THR605U, TRP607U
• A-L: ALA466A, ALA466L, ARG452A, ARG452L, ASN467A, ASN467L, GLU461A, GLU461L, LYS470A, LYS470L, PRO462A, PRO462L, SER463A, SER463L, THR468A, THR468L, TYR485A, TYR485L, VAL464A, VAL464L, VAL465A, VAL465L
• A-M: ALA106A, ALA106M, ALA108A, ALA108M, ALA109A, ALA109M, ARG445A, GLU102A, GLU102M, GLU434A, GLU434M, GLY110A, GLY110M, LEU104A, LEU104M, LYS105A, LYS105M, LYS441A, LYS441M, MET111A, MET111M, VAL107A, VAL107M, VAL438A
• O-B: ARG231B, ASN229B, GLY608O, PHE609O, PRO606O, THR604O, THR605O, TRP607O
• O-P: GLY608O, HIS611P, LEU610O, MET603P, PHE609O, PRO606O, PRO612P, SER601P, THR604O, THR605O, TRP602P, TRP607O
• O-G: ARG268G, ASN265G, GLY269G, HIS611O, ILE270G, MET267G, MET603O, PRO612O, SER601O, TRP602O, VAL264G
• O-U: GLY608U, HIS611O, LEU610U, MET603O, PHE609U, PRO606U, PRO612O, SER601O, THR604U, THR605U, TRP602O, TRP607U
• B-P: ALA239B, ALA241B, ALA258B, ALA260B, ARG231B, ARG268B, ASN229B, ASN265B, GLU238B, GLU257B, GLY256B, GLY608P, HIS611P, ILE230B, ILE270B, LEU234B, LEU237B, LEU247B, LEU259B, LEU262B, LEU610P, LYS242B, LYS272B, MET233B, MET603P, PHE609P, PRO235B, PRO606P, PRO612P, SER228B, SER601P, THR261B, THR266B, THR604P, THR605P, TRP602P, TRP607P, VAL236B, VAL240B, VAL263B, VAL264B, VAL271B, VAL273B
• B-C: ALA12C, ALA241B, ALA243B, ALA24B, ALA258C, ALA26B, ALA278C, ALA2C, ALA383B, ALA384B, ALA3C, ALA46B, ALA480B, ALA481B, ALA57B, ALA71C, ARG118C, ARG13C, ARG197C, ARG231C, ARG268B, ARG284C, ARG285C, ARG322B, ARG36B, ARG58B, ASN112C, ASN206B, ASN21B, ASN229C, ASN265B, ASN37B, ASN433C, ASN457B, ASN68B, ASN68C, ASP115C, ASP179B, ASP253C, ASP25B, ASP283C, ASP361C, ASP41B, ASP435C, ASP523C, ASP5C, ASP64B, CYS458B, CYS519C, GLN184B, GLN436C, GLN72B, GLN72C, GLU186B, GLU214B, GLU216B, GLU232C, GLU252C, GLU255C, GLU257C, GLU303C, GLU308C, GLU310C, GLU386B, GLU388B, GLU460B, GLU483B, GLU518C, GLU59B, GLU61B, GLU61C, GLU63B, GLU67C, GLU76C, GLY180B, GLY182B, GLY244B, GLY256C, GLY269B, GLY280C, GLY282C, GLY32B, GLY35B, GLY382B, GLY459B, GLY45B, GLY512C, GLY70C, GLY9C, ILE227C, ILE230C, ILE270B, ILE49B, ILE515C, ILE60B, LEU183B, LEU23B, LEU40B, LEU456B, LEU513C, LEU524C, LEU62B, LYS117C, LYS207B, LYS225C, LYS226C, LYS242B, LYS245B, LYS272B, LYS277C, LYS286C, LYS28B, LYS34B, LYS364C, LYS390B, LYS42B, LYS4C, LYS51B, LYS526C, LYS65B, LYS65C, LYS75B, LYS75C, LYS7C, LYS80C, MET111C, MET114C, MET16C, MET267B, MET389B, MET514C, MET520C, MET69C, MET73C, PHE281C, PHE44B, PHE66C, PHE8C, PRO113C, PRO279C, PRO33B, PRO47B, PRO525C, SER217B, SER228C, SER358C, SER43B, SER509C, SER55B, THR181B, THR261C, THR266B, THR30B, THR357C, THR385B, THR482B, THR48B, THR50B, THR516C, THR517C, THR522C, TYR360C, VAL107C, VAL22B, VAL264B, VAL271B, VAL27B, VAL29B, VAL381B, VAL387B, VAL38B, VAL39B, VAL455B, VAL510C, VAL521C, VAL56B, VAL6C, VAL74C, VAL77C
• B-Q: ARG268B, ASN265B, GLY269B, HIS611Q, ILE270B, MET267B, MET603Q, PRO612Q, SER601Q, TRP602Q
• B-D: ALA2D, PHE44B
• B-K: ALA466B, ALA466K, ARG452B, ARG452K, ASN467B, ASN467K, GLU461B, GLU461K, LYS470B, LYS470K, PRO462B, PRO462K, SER463B, SER463K, THR468B, THR468K, TYR485B, TYR485K, VAL464B, VAL464K, VAL465B, VAL465K
• B-L: ALA106B, ALA106L, ALA108B, ALA108L, ALA109B, ALA109L, ARG430B, ARG430L, ARG445B, ARG445L, ASN437B, ASN437L, GLU102B, GLU102L, GLU434B, GLU434L, GLY110B, GLY110L, LEU104B, LEU104L, LYS105B, LYS105L, LYS441B, LYS441L, MET111B, MET111L, VAL107B, VAL107L, VAL438B, VAL438L
• P-C: ARG231C, ASN229C, GLY608P, PHE609P, PRO606P, THR604P, THR605P, TRP607P
• P-Q: GLY608P, HIS611Q, LEU610P, MET603Q, PHE609P, PRO606P, PRO612Q, SER601Q, THR604P, THR605P, TRP602Q, TRP607P
• C-Q: ALA239C, ALA241C, ALA258C, ALA260C, ARG231C, ARG268C, ASN229C, ASN265C, GLU238C, GLU257C, GLY256C, GLY608Q, HIS611Q, ILE230C, ILE270C, LEU234C, LEU237C, LEU247C, LEU259C, LEU262C, LEU610Q, LYS242C, LYS272C, MET233C, MET603Q, PHE609Q, PRO235C, PRO606Q, PRO612Q, SER228C, SER601Q, THR261C, THR266C, THR604Q, THR605Q, TRP602Q, TRP607Q, VAL236C, VAL240C, VAL263C, VAL264C, VAL271C, VAL273C
• C-D: ALA12D, ALA241C, ALA243C, ALA24C, ALA258D, ALA26C, ALA278D, ALA2D, ALA383C, ALA384C, ALA3D, ALA46C, ALA480C, ALA481C, ALA57C, ALA71D, ARG118D, ARG13D, ARG197D, ARG231D, ARG268C, ARG284D, ARG285D, ARG36C, ARG58C, ASN112D, ASN206C, ASN21C, ASN229D, ASN265C, ASN37C, ASN433D, ASN457C, ASN68C, ASN68D, ASP115D, ASP179C, ASP253D, ASP25C, ASP283D, ASP361D, ASP41C, ASP435D, ASP523D, ASP5D, ASP64C, CYS458C, CYS519D, GLN184C, GLN436D, GLN72C, GLN72D, GLU214C, GLU216C, GLU232D, GLU252D, GLU255D, GLU257D, GLU303D, GLU308D, GLU310D, GLU386C, GLU388C, GLU460C, GLU483C, GLU518D, GLU59C, GLU61C, GLU63C, GLU76D, GLY180C, GLY182C, GLY244C, GLY256D, GLY269C, GLY280D, GLY282D, GLY32C, GLY35C, GLY382C, GLY459C, GLY45C, GLY512D, GLY70D, GLY9D, ILE227D, ILE230D, ILE270C, ILE49C, ILE515D, ILE60C, LEU183C, LEU23C, LEU40C, LEU456C, LEU513D, LEU524D, LEU62C, LYS117D, LYS207C, LYS225D, LYS226D, LYS242C, LYS245C, LYS272C, LYS277D, LYS286D, LYS28C, LYS34C, LYS364D, LYS390C, LYS42C, LYS4D, LYS51C, LYS526D, LYS65C, LYS65D, LYS75C, LYS75D, LYS7D, LYS80D, MET111D, MET114D, MET16D, MET267C, MET389C, MET514D, MET520D, MET69D, MET73D, PHE281D, PHE44C, PHE66D, PHE8D, PRO113D, PRO33C, PRO47C, PRO525D, SER217C, SER228D, SER358D, SER43C, SER509D, SER55C, THR181C, THR261D, THR266C, THR30C, THR385C, THR482C, THR48C, THR50C, THR516D, THR517D, THR522D, TYR360D, VAL107D, VAL22C, VAL264C, VAL271C, VAL27C, VAL29C, VAL381C, VAL387C, VAL38C, VAL39C, VAL455C, VAL510D, VAL521D, VAL56C, VAL6D, VAL74D, VAL77D
• C-R: ARG268C, ASN265C, GLY269C, HIS611R, ILE270C, MET267C, MET603R, PRO612R, SER601R, TRP602R
• C-J: ALA466C, ALA466J, ARG452C, ARG452J, ASN467C, ASN467J, GLU448C, GLU461C, GLU461J, LYS470C, LYS470J, PRO462C, PRO462J, SER463C, SER463J, THR468C, THR468J, TYR485C, TYR485J, VAL464C, VAL464J, VAL465C, VAL465J
• C-K: ALA106C, ALA106K, ALA108C, ALA108K, ALA109C, ALA109K, ARG430C, ARG430K, ARG445C, ARG445K, ASN437C, ASN437K, GLU102C, GLU102K, GLU434C, GLU434K, GLY110C, GLY110K, LEU104C, LEU104K, LYS105C, LYS105K, LYS441C, LYS441K, MET111C, MET111K, VAL107C, VAL107K, VAL438C, VAL438K
• Q-D: ARG231D, ASN229D, GLY608Q, PHE609Q, PRO606Q, THR604Q, THR605Q, TRP607Q
• Q-R: GLY608Q, HIS611R, LEU610Q, MET603R, PHE609Q, PRO606Q, PRO612R, SER601R, THR604Q, THR605Q, TRP602R, TRP607Q
• D-R: ALA239D, ALA241D, ALA258D, ALA260D, ARG231D, ARG268D, ASN229D, ASN265D, GLU238D, GLU257D, GLY256D, GLY608R, HIS611R, ILE230D, ILE270D, LEU234D, LEU237D, LEU247D, LEU259D, LEU262D, LEU610R, LYS242D, LYS272D, MET233D, MET603R, PHE609R, PRO235D, PRO606R, PRO612R, SER228D, SER601R, THR261D, THR266D, THR604R, THR605R, TRP602R, TRP607R, VAL236D, VAL240D, VAL263D, VAL264D, VAL271D, VAL273D
• D-E: ALA12E, ALA241D, ALA243D, ALA24D, ALA258E, ALA26D, ALA278E, ALA2E, ALA383D, ALA384D, ALA3E, ALA46D, ALA480D, ALA481D, ALA57D, ALA71E, ARG118E, ARG13E, ARG197E, ARG231E, ARG268D, ARG284E, ARG285E, ARG322D, ARG36D, ARG58D, ASN112E, ASN206D, ASN21D, ASN229E, ASN265D, ASN37D, ASN433E, ASN457D, ASN68D, ASN68E, ASP115E, ASP179D, ASP196E, ASP253E, ASP25D, ASP283E, ASP361E, ASP41D, ASP435E, ASP523E, ASP5E, ASP64D, CYS458D, CYS519E, GLN184D, GLN432E, GLN436E, GLN453D, GLN72D, GLN72E, GLU186D, GLU214D, GLU216D, GLU232E, GLU252E, GLU255E, GLU257E, GLU303E, GLU308E, GLU310E, GLU386D, GLU388D, GLU460D, GLU483D, GLU518E, GLU59D, GLU61D, GLU61E, GLU63D, GLU76E, GLY180D, GLY182D, GLY244D, GLY256E, GLY269D, GLY280E, GLY282E, GLY32D, GLY35D, GLY382D, GLY459D, GLY45D, GLY512E, GLY70E, GLY9E, ILE227E, ILE230E, ILE270D, ILE49D, ILE515E, ILE60D, LEU116E, LEU183D, LEU215D, LEU23D, LEU40D, LEU456D, LEU513E, LEU524E, LEU62D, LYS117E, LYS207D, LYS225E, LYS226E, LYS242D, LYS245D, LYS272D, LYS277E, LYS286E, LYS28D, LYS34D, LYS364E, LYS390D, LYS42D, LYS4E, LYS51D, LYS526E, LYS65D, LYS65E, LYS75D, LYS75E, LYS7E, LYS80E, MET111E, MET114E, MET16E, MET267D, MET389D, MET514E, MET520E, MET69E, MET73E, PHE281E, PHE66E, PHE8E, PRO113E, PRO279E, PRO33D, PRO47D, PRO525E, SER217D, SER228E, SER358E, SER43D, SER509E, SER55D, THR181D, THR261E, THR266D, THR30D, THR357E, THR385D, THR482D, THR48D, THR50D, THR516E, THR517E, THR522E, TYR360E, VAL107E, VAL22D, VAL264D, VAL271D, VAL27D, VAL29D, VAL381D, VAL387D, VAL38D, VAL39D, VAL455D, VAL510E, VAL521E, VAL56D, VAL6E, VAL74E, VAL77E
• D-S: ARG268D, ASN265D, GLY269D, HIS611S, ILE270D, MET267D, MET603S, PRO612S, SER601S, TRP602S
• D-I: ALA466D, ALA466I, ARG452D, ARG452I, ASN467D, ASN467I, GLU461D, GLU461I, LYS470D, LYS470I, PRO462D, PRO462I, SER463D, SER463I, THR468D, THR468I, TYR485D, TYR485I, VAL464D, VAL464I, VAL465D, VAL465I
• D-J: ALA106D, ALA106J, ALA108D, ALA108J, ALA109D, ALA109J, ARG430D, ARG430J, ARG445D, ARG445J, ASN437D, ASN437J, GLU102D, GLU102J, GLU434D, GLU434J, GLY110D, GLY110J, LEU104D, LEU104J, LYS105D, LYS105J, LYS441D, LYS441J, MET111D, MET111J, VAL107D, VAL107J, VAL438D, VAL438J
• R-E: ARG231E, ASN229E, GLY608R, LEU610R, PHE609R, PRO606R, THR604R, THR605R, TRP607R
• R-S: GLY608R, HIS611S, LEU610R, MET603S, PHE609R, PRO606R, PRO612S, SER601S, THR604R, THR605R, TRP602S, TRP607R
• E-S: ALA239E, ALA241E, ALA258E, ALA260E, ARG231E, ARG268E, ASN229E, ASN265E, GLU238E, GLU257E, GLY256E, GLY608S, HIS611S, ILE230E, ILE270E, LEU234E, LEU237E, LEU247E, LEU259E, LEU262E, LEU610S, LYS242E, LYS272E, MET233E, MET603S, PHE609S, PRO235E, PRO606S, PRO612S, SER228E, SER601S, THR261E, THR266E, THR604S, THR605S, TRP602S, TRP607S, VAL236E, VAL240E, VAL263E, VAL264E, VAL271E, VAL273E
• E-F: ALA12F, ALA241E, ALA243E, ALA24E, ALA258F, ALA26E, ALA278F, ALA2F, ALA383E, ALA384E, ALA3F, ALA46E, ALA480E, ALA481E, ALA57E, ALA71F, ARG118F, ARG13F, ARG197F, ARG231F, ARG268E, ARG284F, ARG285F, ARG322E, ARG36E, ARG58E, ASN112F, ASN206E, ASN21E, ASN229F, ASN265E, ASN37E, ASN433F, ASN457E, ASN68E, ASN68F, ASP115F, ASP179E, ASP196F, ASP253F, ASP25E, ASP283F, ASP361F, ASP41E, ASP435F, ASP523F, ASP5F, ASP64E, CYS458E, CYS519F, GLN184E, GLN436F, GLN72E, GLN72F, GLU186E, GLU214E, GLU216E, GLU232F, GLU252F, GLU255F, GLU257F, GLU303F, GLU308F, GLU310F, GLU386E, GLU388E, GLU460E, GLU483E, GLU518F, GLU59E, GLU61E, GLU63E, GLU76F, GLY180E, GLY182E, GLY244E, GLY256F, GLY269E, GLY280F, GLY282F, GLY32E, GLY35E, GLY382E, GLY459E, GLY45E, GLY512F, GLY70F, GLY9F, ILE227F, ILE230F, ILE270E, ILE49E, ILE515F, ILE60E, LEU183E, LEU215E, LEU23E, LEU40E, LEU456E, LEU513F, LEU524F, LEU62E, LYS117F, LYS207E, LYS225F, LYS226F, LYS242E, LYS245E, LYS272E, LYS277F, LYS286F, LYS28E, LYS34E, LYS364F, LYS390E, LYS42E, LYS4F, LYS51E, LYS526F, LYS65E, LYS65F, LYS75E, LYS75F, LYS7F, LYS80F, MET111F, MET114F, MET16F, MET267E, MET389E, MET514F, MET520F, MET69F, MET73F, PHE281F, PHE66F, PHE8F, PRO113F, PRO246E, PRO33E, PRO47E, PRO525F, SER217E, SER228F, SER358F, SER43E, SER509F, SER55E, THR181E, THR261F, THR266E, THR30E, THR357F, THR385E, THR482E, THR48E, THR50E, THR516F, THR517F, THR522F, TYR360F, VAL107F, VAL22E, VAL264E, VAL271E, VAL27E, VAL29E, VAL381E, VAL387E, VAL38E, VAL39E, VAL455E, VAL510F, VAL521F, VAL56E, VAL6F, VAL74F, VAL77F
• E-T: ARG268E, ASN265E, GLY269E, HIS611T, ILE270E, MET267E, MET603T, PRO612T, SER601T, TRP602T
• E-H: ALA466E, ALA466H, ARG452E, ARG452H, ASN467E, ASN467H, GLU448E, GLU461E, GLU461H, LYS470E, LYS470H, PRO462E, PRO462H, SER463E, SER463H, THR468E, THR468H, TYR485E, TYR485H, VAL464E, VAL464H, VAL465E, VAL465H
• E-I: ALA106E, ALA106I, ALA108E, ALA108I, ALA109E, ALA109I, ARG430E, ARG430I, ARG445E, ARG445I, ASN437E, ASN437I, GLU102E, GLU102I, GLU434E, GLU434I, GLY110E, GLY110I, LEU104E, LEU104I, LYS105E, LYS105I, LYS441E, LYS441I, MET111E, MET111I, VAL107E, VAL107I, VAL438E, VAL438I
• S-F: ARG231F, ASN229F, GLY608S, PHE609S, PRO606S, THR604S, THR605S, TRP607S
• S-T: GLY608S, HIS611T, LEU610S, MET603T, PHE609S, PRO606S, PRO612T, SER601T, THR604S, THR605S, TRP602T, TRP607S
• F-T: ALA239F, ALA241F, ALA258F, ALA260F, ARG231F, ARG268F, ASN229F, ASN265F, GLU238F, GLU257F, GLY256F, GLY608T, HIS611T, ILE230F, ILE270F, LEU234F, LEU237F, LEU247F, LEU259F, LEU262F, LEU610T, LYS242F, LYS272F, MET233F, MET603T, PHE609T, PRO235F, PRO606T, PRO612T, SER228F, SER601T, THR261F, THR266F, THR604T, THR605T, TRP602T, TRP607T, VAL236F, VAL240F, VAL263F, VAL264F, VAL271F, VAL273F
• F-G: ALA12G, ALA241F, ALA243F, ALA24F, ALA258G, ALA26F, ALA278G, ALA2G, ALA383F, ALA384F, ALA3G, ALA46F, ALA480F, ALA481F, ALA57F, ALA71G, ARG118G, ARG13G, ARG197G, ARG231G, ARG268F, ARG284G, ARG285G, ARG36F, ARG58F, ASN112G, ASN206F, ASN21F, ASN229G, ASN265F, ASN37F, ASN433G, ASN457F, ASN68F, ASN68G, ASP115G, ASP179F, ASP253G, ASP25F, ASP283G, ASP359G, ASP361G, ASP41F, ASP435G, ASP523G, ASP5G, ASP64F, CYS458F, CYS519G, GLN184F, GLN436G, GLN72F, GLN72G, GLU186F, GLU214F, GLU216F, GLU232G, GLU252G, GLU255G, GLU257G, GLU303G, GLU308G, GLU310G, GLU386F, GLU388F, GLU460F, GLU483F, GLU518G, GLU59F, GLU61F, GLU63F, GLU76G, GLY180F, GLY182F, GLY244F, GLY256G, GLY269F, GLY280G, GLY282G, GLY32F, GLY35F, GLY382F, GLY459F, GLY45F, GLY512G, GLY70G, GLY9G, ILE227G, ILE230G, ILE270F, ILE49F, ILE515G, ILE60F, LEU183F, LEU215F, LEU23F, LEU40F, LEU456F, LEU513G, LEU524G, LEU62F, LYS117G, LYS207F, LYS225G, LYS226G, LYS242F, LYS245F, LYS272F, LYS277G, LYS286G, LYS28F, LYS34F, LYS364G, LYS390F, LYS42F, LYS4G, LYS51F, LYS526G, LYS65F, LYS65G, LYS75F, LYS75G, LYS7G, LYS80G, MET111G, MET114G, MET16G, MET267F, MET389F, MET514G, MET520G, MET69G, MET73G, PHE281G, PHE66G, PHE8G, PRO113G, PRO33F, PRO47F, PRO525G, SER217F, SER228G, SER358G, SER43F, SER509G, SER55F, THR181F, THR261G, THR266F, THR30F, THR357G, THR385F, THR482F, THR48F, THR50F, THR516G, THR517G, THR522G, TYR360G, VAL107G, VAL22F, VAL271F, VAL27F, VAL29F, VAL381F, VAL387F, VAL38F, VAL39F, VAL455F, VAL510G, VAL521G, VAL56F, VAL6G, VAL74G, VAL77G
• F-U: ARG268F, ASN265F, GLY269F, HIS611U, ILE270F, MET267F, MET603U, PRO612U, SER601U, TRP602U
• F-H: ALA106F, ALA106H, ALA108F, ALA108H, ALA109F, ALA109H, ARG430F, ARG430H, ARG445F, ARG445H, ASN437F, ASN437H, GLU102F, GLU102H, GLU434F, GLU434H, GLY110F, GLY110H, LEU104F, LEU104H, LYS105F, LYS105H, LYS441F, LYS441H, MET111F, MET111H, VAL107F, VAL107H, VAL438F, VAL438H
• F-N: GLU461F, GLU461N, SER463F
• T-G: ARG231G, ASN229G, GLY608T, LEU610T, PHE609T, PRO606T, THR604T, THR605T, TRP607T
• T-U: GLY608T, HIS611U, LEU610T, MET603U, PHE609T, PRO606T, PRO612U, SER601U, THR604T, THR605T, TRP602U, TRP607T
• G-U: ALA239G, ALA241G, ALA258G, ALA260G, ARG231G, ARG268G, ASN229G, ASN265G, GLU238G, GLU257G, GLY256G, GLY608U, HIS611U, ILE230G, ILE270G, LEU234G, LEU237G, LEU247G, LEU259G, LEU262G, LEU610U, LYS242G, LYS272G, MET233G, MET603U, PHE609U, PRO235G, PRO606U, PRO612U, SER228G, SER601U, THR261G, THR266G, THR604U, THR605U, TRP602U, TRP607U, VAL236G, VAL240G, VAL263G, VAL264G, VAL271G, VAL273G
• G-M: GLU461G, GLU461M, SER463G
• G-N: GLU434G, GLU434N, LYS441G, LYS441N
• H-V: ALA239H, ALA241H, ALA258H, ALA260H, ARG231H, ARG268H, ASN229H, ASN265H, GLU238H, GLU257H, GLY256H, GLY608V, HIS611V, ILE230H, ILE270H, LEU234H, LEU237H, LEU247H, LEU259H, LEU262H, LEU610V, LYS242H, LYS272H, MET233H, MET603V, PHE609V, PRO235H, PRO606V, PRO612V, SER228H, SER601V, THR261H, THR266H, THR604V, THR605V, TRP602V, TRP607V, VAL236H, VAL240H, VAL263H, VAL264H, VAL271H, VAL273H
• H-I: ALA12I, ALA241H, ALA243H, ALA24H, ALA258I, ALA26H, ALA278I, ALA2I, ALA383H, ALA384H, ALA3I, ALA46H, ALA480H, ALA481H, ALA57H, ALA71I, ARG118I, ARG13I, ARG197I, ARG231I, ARG268H, ARG284I, ARG285I, ARG322H, ARG36H, ARG58H, ASN112I, ASN206H, ASN21H, ASN229I, ASN265H, ASN37H, ASN433I, ASN457H, ASN68H, ASN68I, ASP115I, ASP179H, ASP196I, ASP253I, ASP25H, ASP283I, ASP359I, ASP361I, ASP41H, ASP435I, ASP523I, ASP5I, ASP64H, CYS458H, CYS519I, GLN184H, GLN436I, GLN72H, GLN72I, GLU186H, GLU214H, GLU216H, GLU232I, GLU252I, GLU255I, GLU257I, GLU303I, GLU308I, GLU310I, GLU386H, GLU388H, GLU460H, GLU483H, GLU518I, GLU59H, GLU61H, GLU63H, GLU76I, GLY180H, GLY182H, GLY244H, GLY256I, GLY269H, GLY280I, GLY282I, GLY32H, GLY35H, GLY382H, GLY459H, GLY45H, GLY512I, GLY70I, GLY9I, ILE227I, ILE230I, ILE270H, ILE49H, ILE515I, ILE60H, LEU183H, LEU215H, LEU23H, LEU40H, LEU456H, LEU513I, LEU524I, LEU62H, LYS117I, LYS207H, LYS225I, LYS226I, LYS242H, LYS245H, LYS272H, LYS277I, LYS286I, LYS28H, LYS34H, LYS364I, LYS390H, LYS42H, LYS4I, LYS51H, LYS526I, LYS65H, LYS65I, LYS75H, LYS75I, LYS7I, LYS80I, MET111I, MET114I, MET16I, MET267H, MET389H, MET514I, MET520I, MET69I, MET73I, PHE281I, PHE66I, PHE8I, PRO113I, PRO246H, PRO279I, PRO33H, PRO47H, PRO525I, SER217H, SER228I, SER358I, SER43H, SER509I, SER55H, SER79I, THR181H, THR261I, THR266H, THR30H, THR357I, THR385H, THR482H, THR48H, THR50H, THR516I, THR517I, THR522I, TYR360I, VAL107I, VAL22H, VAL264H, VAL271H, VAL27H, VAL29H, VAL381H, VAL387H, VAL38H, VAL39H, VAL455H, VAL510I, VAL521I, VAL56H, VAL6I, VAL74I, VAL77I
• H-W: ARG268H, ASN265H, GLY269H, HIS611W, ILE270H, MET267H, MET603W, PRO612W, SER601W, TRP602W
• H-N: ARG231H, ARG268N, ARG285H, ARG36N, ASN112H, ASN37N, ASP115H, ASP25N, ASP283H, ASP41N, ASP523H, ASP5H, CYS458N, CYS519H, GLU216N, GLU255H, GLU257H, GLU303H, GLU308H, GLU310H, GLU386N, GLU518H, GLU59N, GLU61N, GLU63N, LYS226H, LYS242N, LYS245N, LYS272N, LYS277H, LYS28N, LYS34N, LYS4H, LYS526H, LYS65H, THR181N, THR516H, THR522H, VAL39N, VAL521H
• H-2: ARG231H, PRO6062
• V-I: ARG231I, ASN229I, GLY608V, PHE609V, PRO606V, THR604V, THR605V, TRP607V
• V-W: GLY608V, HIS611W, LEU610V, MET603W, PHE609V, PRO606V, PRO612W, SER601W, THR604V, THR605V, TRP602W, TRP607V
• V-N: ARG268N, HIS611V
• I-W: ALA239I, ALA241I, ALA258I, ALA260I, ARG231I, ARG268I, ASN229I, ASN265I, GLU238I, GLU257I, GLY256I, GLY608W, HIS611W, ILE230I, ILE270I, LEU234I, LEU237I, LEU247I, LEU259I, LEU262I, LEU610W, LYS242I, LYS272I, MET233I, MET603W, PHE609W, PRO235I, PRO606W, PRO612W, SER228I, SER601W, THR261I, THR266I, THR604W, THR605W, TRP602W, TRP607W, VAL236I, VAL240I, VAL263I, VAL264I, VAL271I, VAL273I
• I-J: ALA12J, ALA241I, ALA243I, ALA24I, ALA258J, ALA26I, ALA278J, ALA2J, ALA383I, ALA384I, ALA3J, ALA46I, ALA480I, ALA481I, ALA57I, ALA71J, ARG118J, ARG13J, ARG197J, ARG231J, ARG268I, ARG284J, ARG285J, ARG36I, ARG58I, ASN112J, ASN206I, ASN21I, ASN229J, ASN265I, ASN37I, ASN433J, ASN457I, ASN68I, ASN68J, ASP115J, ASP179I, ASP253J, ASP25I, ASP283J, ASP361J, ASP41I, ASP435J, ASP523J, ASP5J, ASP64I, CYS458I, CYS519J, GLN184I, GLN436J, GLN72I, GLN72J, GLU186I, GLU214I, GLU216I, GLU232J, GLU252J, GLU255J, GLU257J, GLU303J, GLU308J, GLU310J, GLU386I, GLU388I, GLU460I, GLU483I, GLU518J, GLU59I, GLU61I, GLU63I, GLU76J, GLY180I, GLY182I, GLY244I, GLY256J, GLY269I, GLY280J, GLY282J, GLY32I, GLY35I, GLY382I, GLY459I, GLY45I, GLY512J, GLY70J, GLY9J, ILE227J, ILE230J, ILE270I, ILE49I, ILE515J, ILE60I, LEU183I, LEU215I, LEU23I, LEU40I, LEU456I, LEU513J, LEU524J, LEU62I, LYS117J, LYS207I, LYS225J, LYS226J, LYS242I, LYS245I, LYS272I, LYS277J, LYS286J, LYS28I, LYS34I, LYS364J, LYS390I, LYS42I, LYS4J, LYS51I, LYS526J, LYS65I, LYS65J, LYS75I, LYS75J, LYS7J, LYS80J, MET111J, MET114J, MET16J, MET267I, MET389I, MET514J, MET520J, MET69J, MET73J, PHE281J, PHE44I, PHE66J, PHE8J, PRO113J, PRO246I, PRO279J, PRO33I, PRO47I, PRO525J, SER217I, SER228J, SER358J, SER43I, SER509J, SER55I, SER79J, THR181I, THR261J, THR266I, THR30I, THR357J, THR385I, THR482I, THR48I, THR50I, THR516J, THR517J, THR522J, TYR360J, VAL107J, VAL22I, VAL264I, VAL271I, VAL27I, VAL29I, VAL381I, VAL387I, VAL38I, VAL39I, VAL455I, VAL510J, VAL521J, VAL56I, VAL6J, VAL74J, VAL77J
• I-X: ARG268I, ASN265I, GLY269I, HIS611X, ILE270I, MET267I, MET603X, PRO612X, SER601X, TRP602X
• W-J: ARG231J, ASN229J, GLY608W, PHE609W, PRO606W, THR604W, THR605W, TRP607W
• W-X: GLY608W, HIS611X, LEU610W, MET603X, PHE609W, PRO606W, PRO612X, SER601X, THR604W, THR605W, TRP602X, TRP607W
• J-X: ALA239J, ALA241J, ALA258J, ALA260J, ARG231J, ARG268J, ASN229J, ASN265J, GLU238J, GLU257J, GLY256J, GLY608X, HIS611X, ILE230J, ILE270J, LEU234J, LEU237J, LEU247J, LEU259J, LEU262J, LEU610X, LYS242J, LYS272J, MET233J, MET603X, PHE609X, PRO235J, PRO606X, PRO612X, SER228J, SER601X, THR261J, THR266J, THR604X, THR605X, TRP602X, TRP607X, VAL236J, VAL240J, VAL263J, VAL264J, VAL271J, VAL273J
• J-K: ALA12K, ALA241J, ALA243J, ALA24J, ALA258K, ALA26J, ALA278K, ALA2K, ALA383J, ALA384J, ALA3K, ALA46J, ALA480J, ALA481J, ALA57J, ALA71K, ARG118K, ARG13K, ARG197K, ARG231K, ARG268J, ARG284K, ARG285K, ARG36J, ARG58J, ASN112K, ASN206J, ASN21J, ASN229K, ASN265J, ASN37J, ASN433K, ASN457J, ASN68J, ASN68K, ASP115K, ASP179J, ASP253K, ASP25J, ASP283K, ASP361K, ASP41J, ASP435K, ASP523K, ASP5K, ASP64J, CYS458J, CYS519K, GLN184J, GLN436K, GLN72J, GLN72K, GLU186J, GLU214J, GLU216J, GLU232K, GLU252K, GLU255K, GLU257K, GLU303K, GLU308K, GLU310K, GLU386J, GLU388J, GLU460J, GLU483J, GLU518K, GLU59J, GLU61J, GLU63J, GLU76K, GLY180J, GLY182J, GLY244J, GLY256K, GLY269J, GLY280K, GLY282K, GLY32J, GLY35J, GLY382J, GLY459J, GLY45J, GLY512K, GLY70K, GLY9K, ILE227K, ILE230K, ILE270J, ILE49J, ILE515K, ILE60J, LEU183J, LEU23J, LEU40J, LEU456J, LEU513K, LEU524K, LEU62J, LYS117K, LYS207J, LYS225K, LYS226K, LYS242J, LYS245J, LYS272J, LYS277K, LYS286K, LYS28J, LYS34J, LYS364K, LYS390J, LYS42J, LYS4K, LYS51J, LYS526K, LYS65J, LYS65K, LYS75J, LYS75K, LYS7K, LYS80K, MET111K, MET114K, MET16K, MET267J, MET389J, MET514K, MET520K, MET69K, MET73K, PHE281K, PHE66K, PHE8K, PRO113K, PRO246J, PRO279K, PRO33J, PRO47J, PRO525K, SER217J, SER228K, SER358K, SER43J, SER509K, SER55J, SER79K, THR181J, THR261K, THR266J, THR30J, THR357K, THR385J, THR482J, THR48J, THR50J, THR516K, THR517K, THR522K, TYR360K, VAL107K, VAL22J, VAL264J, VAL271J, VAL27J, VAL29J, VAL381J, VAL387J, VAL38J, VAL39J, VAL455J, VAL510K, VAL521K, VAL56J, VAL6K, VAL74K, VAL77K
• J-Y: ARG268J, ASN265J, GLY269J, HIS611Y, ILE270J, MET267J, MET603Y, PRO612Y, SER601Y, TRP602Y
• X-K: ARG231K, ASN229K, GLY608X, PHE609X, PRO606X, THR604X, THR605X, TRP607X
• X-Y: GLY608X, HIS611Y, LEU610X, MET603Y, PHE609X, PRO606X, PRO612Y, SER601Y, THR604X, THR605X, TRP602Y, TRP607X
• K-Y: ALA239K, ALA241K, ALA258K, ALA260K, ARG231K, ARG268K, ASN229K, ASN265K, GLU238K, GLU257K, GLY256K, GLY608Y, HIS611Y, ILE230K, ILE270K, LEU234K, LEU237K, LEU247K, LEU259K, LEU262K, LEU610Y, LYS242K, LYS272K, MET233K, MET603Y, PHE609Y, PRO235K, PRO606Y, PRO612Y, SER228K, SER601Y, THR261K, THR266K, THR604Y, THR605Y, TRP602Y, TRP607Y, VAL236K, VAL240K, VAL263K, VAL264K, VAL271K, VAL273K
• K-L: ALA12L, ALA241K, ALA243K, ALA24K, ALA258L, ALA26K, ALA278L, ALA2L, ALA383K, ALA384K, ALA3L, ALA46K, ALA480K, ALA481K, ALA57K, ALA71L, ARG118L, ARG13L, ARG197L, ARG231L, ARG268K, ARG284L, ARG285L, ARG36K, ARG58K, ASN112L, ASN206K, ASN21K, ASN229L, ASN265K, ASN37K, ASN433L, ASN457K, ASN68K, ASN68L, ASP115L, ASP179K, ASP253L, ASP25K, ASP283L, ASP361L, ASP41K, ASP435L, ASP523L, ASP5L, ASP64K, CYS458K, CYS519L, GLN184K, GLN432L, GLN436L, GLN72K, GLN72L, GLU214K, GLU216K, GLU232L, GLU252L, GLU255L, GLU257L, GLU303L, GLU308L, GLU310L, GLU386K, GLU388K, GLU460K, GLU483K, GLU518L, GLU59K, GLU61K, GLU63K, GLU76L, GLY180K, GLY182K, GLY244K, GLY256L, GLY269K, GLY280L, GLY282L, GLY32K, GLY35K, GLY382K, GLY459K, GLY45K, GLY512L, GLY70L, GLY9L, ILE227L, ILE230L, ILE270K, ILE49K, ILE515L, ILE60K, LEU183K, LEU23K, LEU40K, LEU456K, LEU513L, LEU524L, LEU62K, LYS117L, LYS207K, LYS225L, LYS226L, LYS242K, LYS245K, LYS272K, LYS277L, LYS286L, LYS28K, LYS34K, LYS364L, LYS390K, LYS42K, LYS4L, LYS51K, LYS526L, LYS65K, LYS65L, LYS75K, LYS75L, LYS7L, LYS80L, MET111L, MET114L, MET16L, MET267K, MET389K, MET514L, MET520L, MET69L, MET73L, PHE281L, PHE66L, PHE8L, PRO113L, PRO246K, PRO33K, PRO47K, PRO525L, SER217K, SER228L, SER358L, SER43K, SER509L, SER55K, SER79L, THR181K, THR261L, THR266K, THR30K, THR385K, THR482K, THR48K, THR50K, THR516L, THR517L, THR522L, TYR360L, VAL107L, VAL22K, VAL271K, VAL27K, VAL29K, VAL381K, VAL387K, VAL38K, VAL39K, VAL455K, VAL510L, VAL521L, VAL56K, VAL6L, VAL74L, VAL77L
• K-Z: ARG268K, ASN265K, GLY269K, HIS611Z, ILE270K, MET267K, MET603Z, PRO612Z, SER601Z, TRP602Z
• Y-L: ARG231L, ASN229L, GLY608Y, PHE609Y, PRO606Y, THR604Y, THR605Y, TRP607Y
• Y-Z: GLY608Y, HIS611Z, LEU610Y, MET603Z, PHE609Y, PRO606Y, PRO612Z, SER601Z, THR604Y, THR605Y, TRP602Z, TRP607Y
• L-Z: ALA239L, ALA241L, ALA258L, ALA260L, ARG231L, ARG268L, ASN229L, ASN265L, GLU238L, GLU257L, GLY256L, GLY608Z, HIS611Z, ILE230L, ILE270L, LEU234L, LEU237L, LEU247L, LEU259L, LEU262L, LEU610Z, LYS242L, LYS272L, MET233L, MET603Z, PHE609Z, PRO235L, PRO606Z, PRO612Z, SER228L, SER601Z, THR261L, THR266L, THR604Z, THR605Z, TRP602Z, TRP607Z, VAL236L, VAL240L, VAL263L, VAL264L, VAL271L, VAL273L
• L-M: ALA12M, ALA243L, ALA24L, ALA26L, ALA2M, ALA3M, ALA46L, ALA480L, ALA481L, ALA57L, ALA71M, ARG118M, ARG13M, ARG197M, ARG231M, ARG268L, ARG285M, ARG322L, ARG36L, ARG58L, ASN112M, ASN21L, ASN37L, ASN457L, ASN68L, ASN68M, ASP115M, ASP179L, ASP25L, ASP283M, ASP41L, ASP523M, ASP5M, ASP64L, CYS458L, CYS519M, GLN72L, GLN72M, GLU214L, GLU216L, GLU255M, GLU257M, GLU303M, GLU310M, GLU386L, GLU460L, GLU483L, GLU518M, GLU59L, GLU61L, GLU63L, GLU76M, GLY244L, GLY269L, GLY32L, GLY35L, GLY459L, GLY45L, GLY70M, GLY9M, ILE227M, ILE49L, ILE60L, LEU23L, LEU40L, LEU456L, LEU62L, LYS117M, LYS207L, LYS225M, LYS226M, LYS242L, LYS245L, LYS272L, LYS277M, LYS28L, LYS34L, LYS390L, LYS42L, LYS4M, LYS51L, LYS526M, LYS65L, LYS65M, LYS75L, LYS75M, LYS7M, LYS80M, MET111M, MET114M, MET16M, MET69M, MET73M, PHE66M, PHE8M, PRO113M, PRO33L, PRO47L, SER43L, SER79M, THR181L, THR482L, THR48L, THR516M, THR522M, VAL107M, VAL22L, VAL27L, VAL29L, VAL387L, VAL38L, VAL39L, VAL455L, VAL521M, VAL56L, VAL6M, VAL74M, VAL77M
• L-1: ARG268L, HIS6111, SER6011
• Z-M: ARG231M, PRO606Z
• M-1: ARG231M, ARG268M, GLU257M, GLY6081, HIS6111, PRO6121
• M-N: ALA2N, ARG268M, ARG285N, ARG36M, ASN112N, ASN37M, ASP115N, ASP25M, ASP41M, ASP523N, ASP5N, CYS458M, CYS519N, GLU216M, GLU255N, GLU257N, GLU303N, GLU308N, GLU310N, GLU386M, GLU518N, GLU59M, GLU61M, GLU63M, LYS226N, LYS242M, LYS245M, LYS272M, LYS277N, LYS34M, LYS4N, LYS526N, LYS65N, THR516N, THR522N, VAL39M, VAL521N
• M-2: ARG268M, HIS6112, PRO6122, SER6012
• 1-N: ARG231N, PRO6061
• N-2: ARG231N, ARG268N, GLU257N, GLY6082, HIS6112, PRO6122