1MMO

crystal structure of a bacterial non-haem iron hydroxylase that catalyses the biological oxidation of methane

• Total interactions analyzed: 15
• Total true interactions: 10
• Strongest Interaction:
  • Chains: C-E
  • Int. Res.: 411
  • Norm. En. per Res.: -5.0513
• Hub Node: B(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
B-C	-87.7427	-357.6043	-459.302	-904.649	185	14	1	17933	26	73	68
B-D	-220.9611	-129.1308	-1683.43	-2033.5219	409	70	32	62214	10	160	124
B-E	0.0	0.576	-46.3824	-45.8064	47	1	1	2493	2	15	14
B-G	-29.9171	-101.1132	-370.302	-501.3323	136	13	6	14413	8	68	70
C-D	0.0	1.2973	-57.4413	-56.144	48	0	0	2781	1	15	14
C-E	-270.9753	-150.0197	-1655.08	-2076.075	411	77	30	62184	12	159	124
C-H	-32.862	-108.6125	-370.198	-511.6726	136	14	6	14334	8	68	68
D-E	-10.384	-19.9776	-168.117	-198.4786	65	14	3	7115	2	18	13
D-G	-113.7689	-27.0404	-582.994	-723.8033	164	27	6	21916	9	80	79
E-H	-105.3478	-28.4099	-572.398	-706.1556	160	26	6	21192	11	81	76

Interface residues

• B-C: ALA107B, ALA107C, ALA114B, ALA114C, ALA129B, ALA129C, ALA135B, ALA135C, ALA17B, ALA17C, ALA18B, ALA18C, ALA269B, ALA269C, ALA27C, ALA284B, ALA284C, ALA354B, ALA354C, ARG104B, ARG104C, ARG118B, ARG118C, ARG122B, ARG122C, ARG134B, ARG134C, ARG261B, ARG261C, ARG262B, ARG262C, ARG267B, ARG267C, ARG271B, ARG271C, ARG358B, ARG358C, ARG8B, ARG8C, ARG9B, ARG9C, ASN137B, ASN137C, ASN275B, ASN275C, ASN282B, ASN282C, ASP112B, ASP112C, ASP121B, ASP121C, ASP130B, ASP130C, ASP13B, ASP13C, ASP274B, ASP274C, ASP361B, ASP361C, ASP362B, ASP362C, ASP366B, ASP366C, GLN125B, GLN125C, GLN132B, GLN132C, GLN258B, GLN258C, GLN266B, GLN266C, GLN283B, GLN283C, GLN285B, GLN285C, GLN289B, GLN289C, GLN293B, GLN293C, GLU115B, GLU115C, GLU116B, GLU116C, GLU15B, GLU15C, GLU263B, GLU263C, GLU26B, GLU26C, GLU351B, GLU365B, GLU365C, GLU6B, GLU6C, GLY10B, GLY10C, GLY126B, GLY126C, GLY131B, GLY131C, GLY273B, GLY273C, ILE133B, ILE133C, ILE20B, ILE20C, ILE281B, ILE281C, ILE290B, ILE290C, LEU102B, LEU102C, LEU11B, LEU11C, LEU124B, LEU124C, LEU21B, LEU21C, LEU24B, LEU268B, LEU268C, LEU276B, LEU276C, LYS111B, LYS111C, LYS113B, LYS113C, LYS22B, LYS22C, LYS292B, LYS292C, MET136B, MET136C, MET16B, MET16C, PHE123B, PHE123C, PHE265B, PHE265C, PHE272B, PHE272C, PHE279B, PHE279C, PHE280B, PHE280C, PHE288B, PHE288C, PRO108B, PRO108C, PRO14B, PRO14C, PRO270B, PRO270C, PRO278B, PRO278C, SER128B, SER128C, SER355B, SER355C, THR120B, THR120C, THR12B, THR12C, THR277C, THR286B, THR286C, TRP117B, TRP117C, TYR109B, TYR109C, TYR119B, TYR119C, TYR127B, TYR127C, TYR287B, TYR287C, TYR357B, TYR357C, VAL110B, VAL110C, VAL19B, VAL19C, VAL359B, VAL359C, VAL360C
• B-D: ALA107B, ALA114B, ALA117D, ALA119D, ALA120D, ALA128D, ALA129B, ALA130D, ALA131D, ALA139D, ALA152D, ALA159D, ALA15D, ALA162B, ALA166D, ALA167B, ALA16D, ALA170B, ALA171D, ALA17B, ALA180B, ALA18B, ALA190B, ALA197D, ALA19D, ALA201B, ALA212B, ALA224D, ALA225D, ALA226D, ALA227B, ALA230B, ALA23B, ALA25D, ALA274D, ALA27B, ALA284B, ALA459D, ALA47D, ALA51B, ALA56B, ALA60B, ALA64D, ALA68D, ALA72D, ALA85D, ALA91D, ARG104B, ARG118B, ARG122B, ARG134B, ARG146D, ARG168B, ARG172D, ARG173D, ARG175D, ARG176B, ARG186D, ARG18D, ARG197B, ARG228B, ARG245D, ARG30D, ARG360D, ARG419D, ARG43D, ARG463D, ARG489D, ARG502D, ARG69D, ARG7B, ARG80B, ARG8B, ARG94D, ARG9B, ASN100D, ASN108D, ASN116D, ASN135D, ASN155B, ASN155D, ASN161B, ASN161D, ASN169D, ASN17D, ASN203D, ASN227D, ASN24D, ASN273D, ASN32B, ASN33B, ASN36D, ASN41D, ASN42D, ASN468D, ASN59B, ASN90D, ASP112B, ASP121B, ASP126D, ASP130B, ASP13B, ASP143D, ASP164D, ASP170D, ASP173B, ASP185B, ASP188B, ASP190D, ASP196D, ASP208B, ASP229D, ASP240B, ASP242D, ASP270D, ASP30B, ASP365D, ASP38D, ASP491D, ASP504D, ASP61B, ASP68B, ASP71B, ASP75D, CYS151D, CYS200D, CYS466D, GLN125B, GLN129D, GLN132B, GLN133D, GLN150D, GLN163D, GLN165B, GLN191B, GLN194B, GLN236B, GLN26D, GLN278D, GLN283B, GLN33D, GLN422D, GLN467D, GLN472D, GLN498D, GLN57B, GLN74B, GLN78D, GLN83D, GLU101D, GLU111D, GLU114D, GLU115B, GLU116B, GLU132D, GLU144D, GLU156B, GLU15B, GLU169B, GLU196B, GLU199D, GLU209B, GLU222D, GLU230D, GLU232B, GLU237B, GLU26B, GLU27D, GLU367D, GLU460D, GLU462D, GLU465D, GLU471D, GLU48B, GLU50B, GLU58D, GLU66D, GLU71D, GLU76D, GLY10B, GLY113D, GLY122D, GLY126B, GLY131B, GLY158B, GLY162D, GLY166B, GLY167D, GLY178D, GLY183B, GLY183D, GLY191D, GLY195D, GLY198B, GLY228D, GLY233B, GLY31B, GLY36B, GLY487D, GLY492D, GLY503D, GLY66B, GLY70B, GLY78B, GLY79B, GLY92D, HIS106B, HIS147D, HIS149D, HIS163B, HIS168D, HIS29D, HIS486D, HIS500D, HIS77B, HIS96D, ILE118D, ILE133B, ILE145D, ILE177D, ILE187B, ILE189B, ILE193B, ILE193D, ILE203B, ILE20B, ILE231D, ILE417D, ILE469D, ILE496D, ILE63D, LEU11B, LEU124B, LEU124D, LEU138D, LEU142D, LEU153B, LEU159B, LEU171B, LEU179B, LEU195B, LEU200B, LEU21B, LEU229B, LEU234B, LEU237D, LEU24B, LEU29B, LEU32D, LEU46B, LEU485D, LEU488D, LEU495D, LEU506D, LEU52B, LEU62D, LEU67B, LEU82D, LEU86D, LEU89D, LYS104D, LYS111B, LYS113B, LYS134D, LYS160D, LYS182D, LYS185D, LYS186B, LYS202B, LYS215B, LYS22B, LYS295D, LYS297D, LYS34B, LYS40D, LYS45D, LYS49D, LYS65D, LYS74D, LYS75B, LYS98D, MET123D, MET16B, MET184D, MET192B, MET35B, MET456D, MET70D, PHE123B, PHE154B, PHE158D, PHE160B, PHE181B, PHE184B, PHE188D, PHE192D, PHE199B, PHE239B, PHE279B, PHE280B, PHE296D, PHE35D, PHE38B, PHE39D, PHE470D, PHE76B, PHE79D, PHE96B, PRO108B, PRO165D, PRO179D, PRO205B, PRO20D, PRO233D, PRO25B, PRO28B, PRO461D, PRO58B, PRO81B, PRO97D, SER127D, SER128B, SER164B, SER172B, SER178B, SER189D, SER194D, SER210B, SER22D, SER244B, SER34D, SER421D, SER490D, SER82B, THR120B, THR121D, THR12B, THR148D, THR174D, THR175B, THR176D, THR211B, THR219B, THR21D, THR221D, THR234D, THR269D, THR277D, THR44D, THR47B, THR494D, THR53B, THR73B, THR87B, TRP105B, TRP117B, TRP125D, TRP181D, TRP182B, TRP218B, TRP223D, TRP235B, TRP241B, TRP31D, TRP37D, TRP62B, TRP69B, TRP72B, TRP83B, TRP99D, TYR109B, TYR115D, TYR119B, TYR127B, TYR137D, TYR153D, TYR156D, TYR157B, TYR157D, TYR287B, TYR37B, TYR464D, TYR46D, TYR473D, TYR49B, TYR55B, TYR67D, VAL110B, VAL112D, VAL141D, VAL154D, VAL174B, VAL177B, VAL187D, VAL19B, VAL204B, VAL231B, VAL238B, VAL23D, VAL28D, VAL298D, VAL39B, VAL420D, VAL481D, VAL501D, VAL54B, VAL73D, VAL93D, VAL95D
• B-E: ALA15E, ALA16E, ALA17B, ALA19E, ALA72E, ALA85E, ALA91E, ARG18E, ARG262B, ARG358B, ARG69E, ARG7B, ARG88E, ARG8B, ARG94E, ARG9B, ASN17E, ASN90E, ASP13B, ASP361B, ASP362B, ASP366B, GLN289B, GLN293B, GLN296B, GLU115B, GLU15B, GLU230E, GLU365B, GLU6B, GLU76E, GLY10B, LEU102B, LEU11B, LEU86E, LEU89E, LYS111B, LYS292B, LYS65E, PHE288B, PRO14B, THR12B, THR87E, TYR119B, TYR367B, VAL359B, VAL73E
• B-G: ALA107G, ALA58G, ALA60B, ALA64B, ALA65G, ALA69G, ALA71G, ARG115G, ARG12G, ARG133G, ARG143G, ARG318B, ARG36G, ARG44G, ARG70G, ARG78G, ARG80B, ARG91B, ASN126G, ASN144G, ASN242B, ASN313B, ASN319B, ASN51G, ASN59B, ASN73G, ASN85B, ASN9G, ASP130G, ASP240B, ASP311B, ASP50G, ASP52G, ASP61B, ASP68B, ASP71B, ASP76G, GLN116G, GLN134G, GLN165B, GLN236B, GLU108G, GLU132G, GLU169B, GLU237B, GLU243B, GLU308B, GLU326B, GLU57G, GLU61G, GLU62G, GLU74G, GLU86B, GLU89B, GLY113G, GLY131G, GLY136G, GLY322B, GLY65B, GLY66B, GLY70B, GLY78B, GLY79B, GLY84B, HIS111G, HIS77B, HIS79G, HIS7G, ILE112G, ILE122G, ILE56G, ILE63B, ILE6G, LEU129G, LEU135G, LEU139G, LEU325B, LEU32G, LEU54G, LEU60G, LEU67B, LEU67G, LEU90B, LEU91G, LYS119G, LYS323B, LYS59G, LYS63G, LYS68G, LYS75B, MET123G, MET140G, MET317B, MET98G, PHE128G, PHE239B, PHE309B, PHE373B, PHE43G, PHE72G, PHE76B, PHE77G, PRO120G, PRO121G, PRO124G, PRO42G, PRO81B, SER244B, SER8G, THR137G, THR315B, THR321B, THR40G, THR41G, THR87B, THR88B, THR92B, TRP241B, TRP320B, TRP324B, TRP55G, TRP62B, TRP69B, TRP72B, TYR118G, TYR127G, TYR147G, TYR312B, TYR53G, VAL125G, VAL238B, VAL316B, VAL64G, VAL66G, VAL75G, VAL93B
• C-D: ALA15D, ALA16D, ALA17C, ALA19D, ALA72D, ALA85D, ALA91D, ARG18D, ARG262C, ARG358C, ARG69D, ARG7C, ARG88D, ARG8C, ARG94D, ARG9C, ASN17D, ASN90D, ASP13C, ASP361C, ASP362C, ASP366C, GLN258C, GLN285C, GLN289C, GLN293C, GLN296C, GLU115C, GLU15C, GLU230D, GLU365C, GLU6C, GLU76D, LEU102C, LEU11C, LEU89D, LYS111C, LYS292C, LYS65D, PHE288C, PRO14C, THR12C, TRP363C, TYR119C, TYR367C, VAL359C, VAL73D, VAL93D
• C-E: ALA107C, ALA114C, ALA117E, ALA119E, ALA120E, ALA128E, ALA129C, ALA130E, ALA131E, ALA139E, ALA152E, ALA159E, ALA15E, ALA162C, ALA166E, ALA167C, ALA16E, ALA170C, ALA171E, ALA17C, ALA180C, ALA18C, ALA190C, ALA197E, ALA19E, ALA201C, ALA212C, ALA224E, ALA225E, ALA226E, ALA227C, ALA230C, ALA23C, ALA25E, ALA274E, ALA27C, ALA284C, ALA459E, ALA47E, ALA51C, ALA56C, ALA60C, ALA64E, ALA68E, ALA72E, ALA85E, ALA91E, ARG104C, ARG118C, ARG122C, ARG134C, ARG146E, ARG168C, ARG172E, ARG173E, ARG175E, ARG176C, ARG186E, ARG18E, ARG197C, ARG228C, ARG245E, ARG30E, ARG360E, ARG419E, ARG43E, ARG463E, ARG489E, ARG502E, ARG69E, ARG7C, ARG80C, ARG8C, ARG94E, ARG9C, ASN100E, ASN108E, ASN116E, ASN135E, ASN155C, ASN155E, ASN161C, ASN161E, ASN169E, ASN17E, ASN203E, ASN220C, ASN227E, ASN24E, ASN273E, ASN32C, ASN33C, ASN36E, ASN41E, ASN42E, ASN468E, ASN59C, ASN90E, ASP112C, ASP121C, ASP126E, ASP130C, ASP13C, ASP143E, ASP164E, ASP170E, ASP173C, ASP185C, ASP188C, ASP190E, ASP196E, ASP208C, ASP229E, ASP240C, ASP242E, ASP270E, ASP30C, ASP38E, ASP491E, ASP504E, ASP61C, ASP68C, ASP71C, ASP75E, CYS151E, CYS200E, CYS466E, GLN125C, GLN129E, GLN132C, GLN133E, GLN140E, GLN150E, GLN163E, GLN165C, GLN191C, GLN194C, GLN236C, GLN26E, GLN283C, GLN33E, GLN422E, GLN467E, GLN472E, GLN498E, GLN57C, GLN74C, GLN78E, GLN83E, GLU101E, GLU111E, GLU114E, GLU115C, GLU116C, GLU132E, GLU144E, GLU156C, GLU15C, GLU169C, GLU196C, GLU199E, GLU209C, GLU222E, GLU230E, GLU232C, GLU237C, GLU26C, GLU27E, GLU367E, GLU460E, GLU462E, GLU465E, GLU471E, GLU484E, GLU48C, GLU50C, GLU58E, GLU66E, GLU71E, GLU76E, GLY10C, GLY113E, GLY122E, GLY126C, GLY131C, GLY158C, GLY162E, GLY166C, GLY167E, GLY178E, GLY183C, GLY183E, GLY191E, GLY195E, GLY198C, GLY228E, GLY233C, GLY31C, GLY36C, GLY487E, GLY492E, GLY503E, GLY66C, GLY70C, GLY78C, GLY79C, GLY92E, HIS106C, HIS147E, HIS149E, HIS163C, HIS168E, HIS29E, HIS486E, HIS500E, HIS77C, HIS96E, ILE118E, ILE133C, ILE145E, ILE177E, ILE187C, ILE189C, ILE193C, ILE193E, ILE203C, ILE20C, ILE231E, ILE417E, ILE469E, ILE496E, ILE63E, LEU11C, LEU124C, LEU124E, LEU138E, LEU142E, LEU153C, LEU159C, LEU171C, LEU179C, LEU195C, LEU200C, LEU21C, LEU229C, LEU234C, LEU237E, LEU24C, LEU29C, LEU32E, LEU46C, LEU485E, LEU488E, LEU495E, LEU506E, LEU52C, LEU62E, LEU67C, LEU82E, LEU86E, LEU89E, LYS104E, LYS111C, LYS113C, LYS134E, LYS160E, LYS182E, LYS185E, LYS186C, LYS202C, LYS215C, LYS22C, LYS295E, LYS297E, LYS34C, LYS40E, LYS45E, LYS49E, LYS61E, LYS65E, LYS74E, LYS75C, LYS98E, MET123E, MET16C, MET184E, MET192C, MET35C, MET456E, MET70E, PHE123C, PHE154C, PHE158E, PHE160C, PHE181C, PHE184C, PHE188E, PHE192E, PHE199C, PHE239C, PHE279C, PHE280C, PHE296E, PHE35E, PHE38C, PHE39E, PHE470E, PHE76C, PHE79E, PHE96C, PRO108C, PRO165E, PRO179E, PRO205C, PRO20E, PRO214C, PRO233E, PRO25C, PRO28C, PRO461E, PRO58C, PRO81C, PRO97E, SER107E, SER127E, SER128C, SER164C, SER172C, SER178C, SER189E, SER194E, SER210C, SER22E, SER244C, SER34E, SER421E, SER490E, SER82C, THR120C, THR121E, THR12C, THR148E, THR174E, THR175C, THR176E, THR211C, THR219C, THR21E, THR221E, THR277E, THR44E, THR47C, THR494E, THR53C, THR73C, THR87C, TRP105C, TRP117C, TRP125E, TRP181E, TRP182C, TRP218C, TRP223E, TRP235C, TRP241C, TRP31E, TRP37E, TRP62C, TRP69C, TRP72C, TRP83C, TRP99E, TYR109C, TYR115E, TYR119C, TYR127C, TYR137E, TYR153E, TYR156E, TYR157C, TYR157E, TYR287C, TYR37C, TYR464E, TYR46E, TYR473E, TYR49C, TYR55C, TYR67E, VAL110C, VAL112E, VAL141E, VAL154E, VAL174C, VAL177C, VAL187E, VAL19C, VAL204C, VAL231C, VAL238C, VAL23E, VAL28E, VAL298E, VAL39C, VAL420E, VAL481E, VAL501E, VAL54C, VAL73E, VAL93E, VAL95E
• C-H: ALA107H, ALA58H, ALA60C, ALA64C, ALA65H, ALA69H, ALA71H, ARG115H, ARG12H, ARG133H, ARG143H, ARG314C, ARG318C, ARG36H, ARG44H, ARG70H, ARG78H, ARG80C, ARG91C, ASN126H, ASN144H, ASN242C, ASN313C, ASN319C, ASN51H, ASN59C, ASN73H, ASN85C, ASN9H, ASP130H, ASP240C, ASP311C, ASP50H, ASP52H, ASP61C, ASP68C, ASP71C, ASP76H, GLN116H, GLN134H, GLN165C, GLN236C, GLU108H, GLU132H, GLU169C, GLU237C, GLU243C, GLU308C, GLU326C, GLU57H, GLU61H, GLU62H, GLU74H, GLU86C, GLU89C, GLY113H, GLY131H, GLY136H, GLY322C, GLY65C, GLY66C, GLY70C, GLY78C, GLY79C, GLY84C, HIS111H, HIS77C, HIS79H, HIS7H, ILE110H, ILE112H, ILE122H, ILE56H, ILE63C, ILE6H, LEU129H, LEU135H, LEU139H, LEU325C, LEU32H, LEU54H, LEU60H, LEU67C, LEU67H, LEU90C, LYS119H, LYS323C, LYS59H, LYS63H, LYS68H, LYS75C, MET123H, MET140H, MET317C, MET98H, PHE128H, PHE239C, PHE309C, PHE373C, PHE72H, PHE76C, PHE77H, PRO120H, PRO121H, PRO124H, PRO42H, PRO81C, SER244C, SER8H, THR137H, THR315C, THR321C, THR40H, THR41H, THR87C, THR88C, THR92C, TRP241C, TRP320C, TRP324C, TRP55H, TRP62C, TRP69C, TRP72C, TYR118H, TYR127H, TYR147H, TYR312C, TYR53H, VAL125H, VAL238C, VAL316C, VAL64H, VAL66H, VAL75H, VAL93C
• D-E: ALA224E, ALA225D, ALA225E, ALA72D, ALA72E, ALA85D, ALA85E, ALA91D, ALA91E, ARG77D, ARG77E, ARG88D, ARG88E, ASP229D, ASP229E, ASP75D, ASP75E, GLN78D, GLN78E, GLN83D, GLN83E, GLU230D, GLU230E, GLU76D, GLU76E, GLY228D, GLY228E, GLY80D, GLY80E, ILE231D, ILE231E, LEU237D, LEU237E, LEU82D, LEU82E, LEU86D, LEU86E, LEU89D, LEU89E, LYS74D, LYS74E, PHE236D, PHE236E, PHE79D, PHE79E, PRO233D, PRO233E, SER238D, SER238E, SER81D, SER81E, THR221D, THR221E, THR232D, THR232E, THR234D, THR234E, THR87D, THR87E, VAL235D, VAL235E, VAL73D, VAL73E, VAL84D, VAL84E
• D-G: ALA197D, ALA262D, ALA264D, ALA274D, ALA459D, ALA47D, ALA525D, ARG115G, ARG12G, ARG133G, ARG138G, ARG143G, ARG156G, ARG159G, ARG162G, ARG173D, ARG330D, ARG419D, ARG437D, ARG43D, ARG44G, ARG455D, ARG463D, ARG476D, ASN126G, ASN144G, ASN146G, ASN268D, ASN272D, ASN273D, ASN41D, ASN442D, ASN45G, ASN468D, ASN51G, ASN521D, ASN9G, ASP126D, ASP130G, ASP149G, ASP196D, ASP270D, ASP38G, ASP450D, ASP50G, ASP52G, CYS200D, CYS466D, GLN116G, GLN134G, GLN158G, GLN451D, GLN467D, GLN472D, GLU108G, GLU132G, GLU141G, GLU153G, GLU154G, GLU199D, GLU440D, GLU444D, GLU454D, GLU460D, GLU462D, GLU465D, GLU471D, GLU474D, GLU477D, GLU480D, GLU484D, GLY131G, GLY136G, GLY160G, GLY195D, GLY443D, GLY453D, GLY475D, GLY5G, HIS111G, HIS165G, HIS39G, HIS439D, HIS446D, HIS486D, HIS7G, ILE112G, ILE177D, ILE469D, ILE482D, ILE6G, LEU129G, LEU135G, LEU139G, LEU142G, LEU145G, LEU152G, LEU155G, LEU267D, LEU271D, LEU436D, LEU458D, LEU485D, LEU49G, LEU4G, LEU54G, LYS104G, LYS157G, LYS182D, LYS265D, LYS45D, LYS49D, LYS524D, MET140G, MET37G, MET445D, MET456D, PHE43G, PHE448D, PHE470D, PHE519D, PHE526D, PRO151G, PRO329D, PRO42G, PRO461D, SER331D, SER434D, SER46G, SER8G, THR137G, THR150G, THR176D, THR269D, THR40G, THR41G, THR435D, THR447D, THR44D, THR48D, TRP105G, TRP276D, TRP452D, TRP457D, TRP55G, TYR147G, TYR148G, TYR266D, TYR416D, TYR441D, TYR464D, TYR46D, TYR473D, TYR47G, TYR50D, TYR53G, VAL161G, VAL163G, VAL164G, VAL198D, VAL438D, VAL481D, VAL518D, VAL523D
• E-H: ALA197E, ALA262E, ALA264E, ALA274E, ALA459E, ALA47E, ALA525E, ARG115H, ARG12H, ARG133H, ARG138H, ARG143H, ARG156H, ARG159H, ARG162H, ARG173E, ARG330E, ARG419E, ARG437E, ARG43E, ARG44H, ARG455E, ARG463E, ARG476E, ASN126H, ASN144H, ASN146H, ASN268E, ASN272E, ASN273E, ASN41E, ASN442E, ASN45H, ASN468E, ASN51H, ASN521E, ASN9H, ASP126E, ASP130H, ASP149H, ASP196E, ASP270E, ASP38H, ASP450E, ASP50H, ASP52H, CYS466E, GLN116H, GLN134H, GLN158H, GLN451E, GLN467E, GLN472E, GLU108H, GLU132H, GLU141H, GLU153H, GLU154H, GLU199E, GLU440E, GLU444E, GLU454E, GLU460E, GLU462E, GLU465E, GLU471E, GLU474E, GLU480E, GLU484E, GLY131H, GLY136H, GLY160H, GLY195E, GLY443E, GLY453E, GLY5H, HIS111H, HIS165H, HIS39H, HIS439E, HIS446E, HIS486E, HIS7H, ILE112H, ILE177E, ILE469E, ILE482E, ILE6H, LEU129H, LEU135H, LEU139H, LEU142H, LEU145H, LEU152H, LEU155H, LEU267E, LEU271E, LEU436E, LEU458E, LEU485E, LEU49H, LEU4H, LEU54H, LYS104H, LYS109H, LYS157H, LYS265E, LYS45E, LYS49E, LYS51E, LYS524E, MET123E, MET140H, MET445E, MET456E, PHE43H, PHE448E, PHE470E, PHE519E, PHE526E, PRO151H, PRO329E, PRO42H, PRO461E, SER331E, SER46H, SER8H, THR137H, THR150H, THR176E, THR269E, THR40H, THR41H, THR435E, THR447E, THR44E, THR48E, TRP105H, TRP276E, TRP452E, TRP457E, TRP55H, TYR147H, TYR148H, TYR266E, TYR416E, TYR441E, TYR464E, TYR46E, TYR473E, TYR47H, TYR50E, TYR53H, VAL161H, VAL163H, VAL164H, VAL198E, VAL438E, VAL481E, VAL523E