1M8Q

molecular models of averaged rigor crossbridges from tomograms of insect flight muscle

• Total interactions analyzed: 325
• Total true interactions: 46
• Strongest Interaction:
  • Chains: A-H
  • Int. Res.: 8
  • Norm. En. per Res.: -1.2764
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-161.0124	2.2594	919.512	760.759	110	284	2	13100	0	15	12
A-C	-42.7299	-38.5352	1031.64	950.3749	108	207	6	12790	3	35	42
A-H	0.0	0.0	-10.211	-10.211	8	0	0	413	0	0	0
A-8	-221.1049	50.1868	6147.21	5976.2918	145	1129	1	28451	0	42	46
A-V	-38.6298	0.8743	1142.02	1104.2645	60	207	2	5625	0	15	15
B-C	0.0	0.0	-0.3104	-0.3104	8	0	0	97	0	2	2
B-H	0.0	0.0	-3.0114	-3.0114	12	0	0	205	0	4	8
B-I	0.0	-2.1654	-0.0998	-2.2652	6	0	0	38	0	4	3
D-E	-7.4086	6.148	1849.45	1848.1894	116	268	3	13312	0	19	13
D-F	-47.7855	-52.8965	1283.21	1182.5279	98	239	7	12563	3	37	31
D-9	-220.7356	50.129	6157.95	5987.3434	145	1129	1	28446	0	42	46
D-W	-38.7905	0.8751	1143.92	1106.0046	60	207	2	5621	0	15	15
E-F	0.0	0.0	-3.9772	-3.9772	14	0	0	363	0	4	2
G-H	-8.2873	-1.9431	412.839	402.6086	125	245	9	16124	0	17	11
G-I	-29.0634	-16.6604	521.529	475.8052	117	255	6	15343	3	43	45
G-V	-220.1344	49.9886	6180.55	6010.4042	145	1127	1	28420	0	42	46
G-X	-18.3119	15.7609	955.346	952.795	51	141	0	4570	0	9	15
H-I	0.0	0.0	-0.1429	-0.1429	8	0	0	41	0	2	3
P-Q	-19.8131	10.1784	1661.83	1652.1953	114	227	7	14541	0	18	12
P-R	-101.6973	0.1753	674.606	573.084	122	224	8	16383	4	47	43
P-0	-221.1729	50.1067			41
7-8	0.0	2.3758	-10.5032	-8.1274	42	0	0	648	3	22	13
7-9	-29.0902	-17.3585	1146.78	1100.3313	64	206	2	5617	0	25	17
8-9	0.0	2.3762	-10.5173	-8.1411	42	0	0	649	3	22	13
8-V	-29.0763	-17.3681	1145.8	1099.3555	64	206	2	5620	0	25	17
9-V	0.0	2.3757	-10.5183	-8.1426	42	0	0	649	3	22	13
9-W	-29.0734	-17.3676	1145.75	1099.309	64	206	2	5618	0	25	17
V-W	0.0	2.3765	-10.5085	-8.132	42	0	0	649	3	22	13
V-X	-62.9637	9.3138	1925.74	1872.0901	63	282	4	5883	0	22	18
W-X	0.0	-2.1839	-4.8316	-7.0155	23	0	0	304	1	16	7
W-Y	-55.3611	12.4382			11
X-Y	0.0	2.1442			6
X-Z	-43.0863	29.6717			11
Y-Z	0.0	-2.8332			2
Y-0	-247.0934	56.2572			11
Z-0	0.0	-2.5677			2
Z-1	0.0	-17.3847			6
0-1	-24.006	22.5463			14
0-2	-111.6773	-62.7299			10
1-2	-4.229	5.5323			9
1-3	0.0	-17.6301			6
2-3	-3.5483	2.8725			8
2-4	-7.2577	-13.5463			10
3-4	-2.9907	2.6852			8
3-5	0.0	-15.9474			9
4-5	-4.3245	3.327			8

Interface residues

• A-B: ALA100B, ALA139B, ALA163B, ALA30B, ALA52B, ALA53B, ALA66B, ALA805A, ALA91B, ARG127B, ARG48B, ARG56B, ARG809A, ARG810A, ARG821A, ASN135B, ASN819A, ASN825A, ASP162B, ASP26B, ASP35B, ASP43B, ASP45B, ASP46B, ASP92B, CYS815A, GLN36B, GLN817A, GLU119B, GLU132B, GLU161B, GLU23B, GLU29B, GLU49B, GLU63B, GLU70B, GLU802A, GLU811A, GLU86B, GLY124B, GLY125B, GLY126B, GLY160B, GLY55B, GLY85B, GLY90B, HIS159B, HIS828A, ILE157B, ILE34B, ILE42B, ILE68B, ILE75B, ILE813A, ILE816A, ILE838A, ILE97B, LEU104B, LEU120B, LEU121B, LEU47B, LEU64B, LEU834A, LEU841A, LEU842A, LEU88B, LYS44B, LYS60B, LYS87B, LYS89B, MET136B, MET54B, MET67B, MET806A, MET824A, MET832A, MET83B, PHE101B, PHE128B, PHE140B, PHE19B, PHE27B, PHE31B, PHE51B, PHE80B, PHE814A, PHE823A, PHE835A, PHE836A, PHE84B, PRO830A, PRO840A, PRO93B, SER812A, SER822A, THR122B, THR123B, THR129B, THR158B, THR50B, TRP829A, TRP831A, TYR155B, TYR818A, VAL156B, VAL33B, VAL59B, VAL820A, VAL826A, VAL96B
• A-C: ALA112C, ALA13C, ALA34C, ALA36C, ALA44C, ALA729A, ALA784A, ALA789A, ALA792A, ARG19C, ARG35C, ARG779A, ARG793A, ARG795A, ARG800A, ARG804A, ARG809A, ARG810A, ASN29A, ASN40C, ASN43C, ASN47C, ASP18C, ASP32C, ASP86C, ASP95C, ASP9C, CYS794A, GLN130C, GLN29C, GLN39C, GLN791A, GLN81C, GLU106C, GLU116C, GLU121C, GLU122C, GLU124C, GLU125C, GLU12C, GLU21A, GLU45C, GLU785A, GLU802A, GLU89C, GLU97C, GLY115C, GLY31C, GLY38C, GLY796A, GLY82C, GLY90C, HIS145C, ILE146C, ILE25A, ILE33C, ILE46C, ILE786A, ILE787A, LEU107C, LEU111C, LEU114C, LEU126C, LEU15C, LEU16C, LEU37C, LEU727A, LEU783A, LEU798A, LEU91C, LYS117C, LYS128C, LYS144C, LYS22A, LYS79C, LYS96C, MET103C, MET118C, MET127C, MET147C, MET799A, MET806A, PHE142C, PHE14C, PHE17C, PHE797A, PHE84C, PHE87C, PHE94C, PRO41C, SER148C, THR113C, THR119C, THR42C, THR788A, THR790A, THR83C, TYR803A, VAL110C, VAL123C, VAL143C, VAL149C, VAL30C, VAL726A, VAL801A, VAL807A, VAL88C, VAL93C
• A-H: GLU21H, GLU25H, ILE838A, LEU834A, LEU841A, LYS28H, PRO840A, THR22H
• A-8: ALA1388, ALA1448, ALA198, ALA228, ALA268, ALA2958, ALA3318, ALA3478, ALA412A, ALA545A, ALA630A, ALA651A, ALA78, ARG1478, ARG288, ARG3358, ARG654A, ASN2968, ASN410A, ASN599A, ASN656A, ASN658A, ASP18, ASP248, ASP258, ASP38, CYS540A, GLN3538, GLN3548, GLN647A, GLU1678, GLU28, GLU3348, GLU3618, GLU411A, GLU48, GLU524A, GLU527A, GLU537A, GLU538A, GLU539A, GLU557A, GLU605A, GLU629A, GLU631A, GLU655A, GLY1468, GLY1688, GLY208, GLY238, GLY3018, GLY3028, GLY3428, GLY3438, GLY407A, GLY409A, GLY531A, GLY628A, GLY632A, GLY633A, GLY634A, GLY635A, GLY638A, GLY639A, GLY643A, HIS558A, ILE1658, ILE3308, ILE3418, ILE3458, ILE526A, ILE532A, ILE535A, LEU1048, LEU1408, LEU1428, LEU3468, LEU3498, LEU525A, LEU536A, LEU554A, LEU596A, LEU652A, LEU88, LYS188, LYS3268, LYS3288, LYS3368, LYS544A, LYS636A, LYS637A, LYS640A, LYS641A, LYS642A, MET2998, MET3058, MET3558, MET530A, MET541A, PHE218, PHE3528, PHE533A, PHE542A, PHE550A, PHE646A, PRO278, PRO3328, PRO3338, PRO529A, PRO543A, SER1418, SER1458, SER3008, SER3388, SER3448, SER3488, SER3508, SER534A, SER549A, SER644A, SER645A, SER650A, THR1488, THR1498, THR3518, THR3588, THR414A, THR58, THR648A, THR68, TRP3408, TRP3568, TYR1338, TYR1438, TYR3378, TYR626A, VAL1398, VAL1528, VAL2988, VAL3398, VAL406A, VAL408A, VAL413A, VAL649A, VAL98
• A-V: ALA545A, ALA571A, ALA577A, ALA97V, ARG95V, ASN552A, ASN92V, ASP51V, ASP547A, ASP556A, CYS540A, GLN41V, GLN49V, GLU100V, GLU538A, GLU539A, GLU557A, GLU576A, GLU57V, GLU99V, GLY42V, GLY46V, GLY48V, GLY560A, HIS558A, HIS87V, HIS88V, ILE535A, ILE592A, LEU536A, LEU554A, LEU559A, LEU596A, LYS50V, LYS544A, LYS561A, LYS567A, LYS569A, LYS61V, MET44V, MET47V, MET530A, MET541A, PHE542A, PHE550A, PHE565A, PRO38V, PRO543A, PRO568A, PRO570A, SER52V, SER549A, THR546A, THR548A, TYR53V, TYR555A, TYR91V, VAL43V, VAL45V, VAL96V
• B-C: ARG19C, GLU121C, GLY124B, GLY125B, GLY126B, THR122B, THR123B, THR129B
• B-H: ALA163B, ALA53B, ASP20H, ASP95H, GLU21H, GLY55B, ILE24H, LEU57B, LEU81H, MET54B, PHE19H, THR82H
• B-I: ASP132I, GLY129I, HIS145I, LYS114B, LYS134B, SER133I
• D-E: ALA100E, ALA138E, ALA139E, ALA163E, ALA30E, ALA52E, ALA53E, ALA66E, ALA805D, ALA91E, ARG127E, ARG48E, ARG56E, ARG809D, ARG810D, ARG821D, ASN135E, ASN819D, ASN825D, ASP162E, ASP26E, ASP35E, ASP43E, ASP45E, ASP46E, ASP92E, CYS154E, CYS815D, GLN36E, GLN817D, GLU119E, GLU132E, GLU161E, GLU23E, GLU29E, GLU49E, GLU62E, GLU63E, GLU70E, GLU802D, GLU808D, GLU811D, GLU86E, GLY124E, GLY125E, GLY126E, GLY160E, GLY55E, GLY85E, GLY90E, GLY99E, HIS159E, HIS828D, ILE153E, ILE157E, ILE34E, ILE42E, ILE68E, ILE75E, ILE813D, ILE816D, ILE838D, ILE97E, LEU104E, LEU120E, LEU121E, LEU47E, LEU64E, LEU834D, LEU841D, LEU842D, LEU88E, LYS44E, LYS60E, LYS87E, LYS89E, MET136E, MET54E, MET67E, MET806D, MET824D, MET832D, MET83E, PHE101E, PHE116E, PHE128E, PHE140E, PHE27E, PHE51E, PHE80E, PHE814D, PHE823D, PHE835D, PHE836D, PHE84E, PRO830D, PRO840D, PRO93E, SER812D, SER822D, THR122E, THR123E, THR129E, THR158E, THR50E, TRP829D, TRP831D, TYR155E, TYR818D, VAL103E, VAL156E, VAL33E, VAL59E, VAL820D, VAL826D, VAL96E
• D-F: ALA112F, ALA13F, ALA34F, ALA36F, ALA44F, ALA784D, ALA789D, ALA792D, ALA805D, ARG19F, ARG35F, ARG723D, ARG725D, ARG779D, ARG793D, ARG795D, ARG800D, ARG804D, ARG809D, ARG810D, ASN40F, ASN43F, ASN47F, ASP32F, ASP86F, ASP9F, CYS794D, GLN130F, GLN29F, GLN39F, GLN722D, GLN791D, GLN81F, GLU116F, GLU121F, GLU122F, GLU124F, GLU125F, GLU45F, GLU785D, GLU802D, GLU85F, GLU89F, GLY115F, GLY31F, GLY38F, GLY796D, GLY82F, GLY90F, HIS145F, ILE146F, ILE33F, ILE46F, ILE786D, ILE787D, LEU107F, LEU111F, LEU114F, LEU126F, LEU15F, LEU16F, LEU37F, LEU783D, LEU798D, LEU91F, LYS117F, LYS128F, LYS144F, LYS79F, MET118F, MET127F, MET147F, MET799D, MET806D, PHE142F, PHE17F, PHE797D, PHE84F, PHE87F, PHE94F, PRO41F, SER148F, THR113F, THR119F, THR42F, THR788D, THR790D, THR83F, TYR803D, VAL110F, VAL123F, VAL143F, VAL149F, VAL726D, VAL801D, VAL807D, VAL88F, VAL93F
• D-9: ALA1389, ALA1449, ALA199, ALA229, ALA269, ALA2959, ALA3319, ALA3479, ALA412D, ALA545D, ALA630D, ALA651D, ALA79, ARG1479, ARG289, ARG3359, ARG654D, ASN2969, ASN410D, ASN599D, ASN656D, ASN658D, ASP19, ASP249, ASP259, ASP39, CYS540D, GLN3539, GLN3549, GLN647D, GLU1679, GLU29, GLU3349, GLU3619, GLU411D, GLU49, GLU524D, GLU527D, GLU537D, GLU538D, GLU539D, GLU557D, GLU605D, GLU629D, GLU631D, GLU655D, GLY1469, GLY1689, GLY209, GLY239, GLY3019, GLY3029, GLY3429, GLY3439, GLY407D, GLY409D, GLY531D, GLY628D, GLY632D, GLY633D, GLY634D, GLY635D, GLY638D, GLY639D, GLY643D, HIS558D, ILE1659, ILE3309, ILE3419, ILE3459, ILE526D, ILE532D, ILE535D, LEU1049, LEU1409, LEU1429, LEU3469, LEU3499, LEU525D, LEU536D, LEU554D, LEU596D, LEU652D, LEU89, LYS189, LYS3269, LYS3289, LYS3369, LYS544D, LYS636D, LYS637D, LYS640D, LYS641D, LYS642D, MET2999, MET3059, MET3559, MET530D, MET541D, PHE219, PHE3529, PHE533D, PHE542D, PHE550D, PHE646D, PRO279, PRO3329, PRO3339, PRO529D, PRO543D, SER1419, SER1459, SER3009, SER3389, SER3449, SER3489, SER3509, SER534D, SER549D, SER644D, SER645D, SER650D, THR1489, THR1499, THR3519, THR3589, THR414D, THR59, THR648D, THR69, TRP3409, TRP3569, TYR1339, TYR1439, TYR3379, TYR626D, VAL1399, VAL1529, VAL2989, VAL3399, VAL406D, VAL408D, VAL413D, VAL649D, VAL99
• D-W: ALA545D, ALA571D, ALA577D, ALA97W, ARG95W, ASN552D, ASN92W, ASP51W, ASP547D, ASP556D, CYS540D, GLN41W, GLN49W, GLU100W, GLU538D, GLU539D, GLU557D, GLU576D, GLU57W, GLU99W, GLY42W, GLY46W, GLY48W, GLY560D, HIS558D, HIS87W, HIS88W, ILE535D, ILE592D, LEU536D, LEU554D, LEU559D, LEU596D, LYS50W, LYS544D, LYS561D, LYS567D, LYS569D, LYS61W, MET44W, MET47W, MET530D, MET541D, PHE542D, PHE550D, PHE565D, PRO38W, PRO543D, PRO568D, PRO570D, SER52W, SER549D, THR546D, THR548D, TYR53W, TYR555D, TYR91W, VAL43W, VAL45W, VAL96W
• E-F: ARG127E, ARG19F, GLU121F, GLY124E, GLY125E, GLY126E, LEU120E, LEU121E, PHE116E, PHE128E, PRO130E, THR122E, THR123E, THR129E
• G-H: ALA100H, ALA138H, ALA139H, ALA30H, ALA52H, ALA53H, ALA66H, ALA71H, ALA91H, ARG127H, ARG48H, ARG56H, ARG809G, ARG810G, ARG821G, ASN135H, ASN152H, ASN819G, ASN825G, ASP162H, ASP26H, ASP35H, ASP43H, ASP46H, ASP65H, ASP92H, CYS154H, CYS815G, GLN36H, GLN817G, GLU132H, GLU161H, GLU23H, GLU25H, GLU29H, GLU49H, GLU63H, GLU70H, GLU808G, GLU811G, GLU86H, GLY124H, GLY125H, GLY126H, GLY160H, GLY85H, GLY90H, GLY99H, HIS159H, HIS828G, ILE153H, ILE157H, ILE24H, ILE34H, ILE42H, ILE68H, ILE75H, ILE813G, ILE816G, ILE838G, ILE97H, LEU104H, LEU117H, LEU120H, LEU121H, LEU47H, LEU64H, LEU834G, LEU841G, LEU842G, LEU88H, LYS102H, LYS28H, LYS44H, LYS843G, LYS87H, LYS89H, MET136H, MET54H, MET67H, MET806G, MET824G, MET832G, MET83H, MET98H, PHE101H, PHE116H, PHE128H, PHE140H, PHE19H, PHE27H, PHE31H, PHE51H, PHE77H, PHE80H, PHE814G, PHE823G, PHE835G, PHE836G, PHE84H, PRO830G, PRO840G, PRO93H, SER812G, SER822G, THR122H, THR123H, THR129H, THR158H, THR22H, THR32H, THR50H, TRP137H, TRP829G, TRP831G, TYR155H, TYR818G, VAL103H, VAL144H, VAL156H, VAL33H, VAL59H, VAL820G, VAL826G, VAL96H
• G-I: ALA105I, ALA112I, ALA13I, ALA34I, ALA36I, ALA44I, ALA729G, ALA731G, ALA784G, ALA789G, ALA792G, ALA805G, ARG108I, ARG19I, ARG35I, ARG725G, ARG779G, ARG793G, ARG795G, ARG800G, ARG804G, ARG809G, ASN40I, ASN43I, ASN47I, ASN728G, ASN78I, ASP32I, ASP752G, ASP754G, ASP80I, ASP86I, CYS794G, GLN130I, GLN39I, GLN791G, GLN81I, GLU106I, GLU116I, GLU120I, GLU121I, GLU122I, GLU124I, GLU125I, GLU45I, GLU734G, GLU785G, GLU802G, GLU85I, GLU89I, GLY115I, GLY31I, GLY38I, GLY749G, GLY750G, GLY751G, GLY796G, GLY82I, GLY90I, HIS109I, HIS145I, HIS755G, ILE146I, ILE46I, ILE732G, ILE786G, ILE787G, LEU107I, LEU111I, LEU114I, LEU126I, LEU16I, LEU37I, LEU727G, LEU747G, LEU748G, LEU783G, LEU798G, LEU91I, LYS117I, LYS128I, LYS144I, LYS746G, LYS79I, MET103I, MET118I, MET127I, MET147I, MET799G, MET806G, PHE142I, PHE17I, PHE797G, PHE84I, PHE87I, PHE94I, PRO41I, PRO733G, SER148I, SER730G, THR113I, THR119I, THR42I, THR788G, THR790G, THR83I, TYR724G, TYR803G, VAL110I, VAL123I, VAL143I, VAL149I, VAL726G, VAL753G, VAL801G, VAL88I, VAL93I
• G-V: ALA138V, ALA144V, ALA19V, ALA22V, ALA26V, ALA295V, ALA331V, ALA347V, ALA412G, ALA545G, ALA630G, ALA651G, ALA7V, ARG147V, ARG28V, ARG335V, ARG654G, ASN296V, ASN410G, ASN599G, ASN656G, ASN658G, ASP1V, ASP24V, ASP25V, ASP3V, CYS540G, GLN353V, GLN354V, GLN647G, GLU167V, GLU2V, GLU334V, GLU361V, GLU411G, GLU4V, GLU524G, GLU527G, GLU537G, GLU538G, GLU539G, GLU557G, GLU605G, GLU629G, GLU631G, GLU655G, GLY146V, GLY168V, GLY20V, GLY23V, GLY301V, GLY302V, GLY342V, GLY343V, GLY407G, GLY409G, GLY531G, GLY628G, GLY632G, GLY633G, GLY634G, GLY635G, GLY638G, GLY639G, GLY643G, HIS558G, ILE165V, ILE330V, ILE341V, ILE345V, ILE526G, ILE532G, ILE535G, LEU104V, LEU140V, LEU142V, LEU346V, LEU349V, LEU525G, LEU536G, LEU554G, LEU596G, LEU652G, LEU8V, LYS18V, LYS326V, LYS328V, LYS336V, LYS544G, LYS636G, LYS637G, LYS640G, LYS641G, LYS642G, MET299V, MET305V, MET355V, MET530G, MET541G, PHE21V, PHE352V, PHE533G, PHE542G, PHE550G, PHE646G, PRO27V, PRO332V, PRO333V, PRO529G, PRO543G, SER141V, SER145V, SER300V, SER338V, SER344V, SER348V, SER350V, SER534G, SER549G, SER644G, SER645G, SER650G, THR148V, THR149V, THR351V, THR358V, THR414G, THR5V, THR648G, THR6V, TRP340V, TRP356V, TYR133V, TYR143V, TYR337V, TYR626G, VAL139V, VAL152V, VAL298V, VAL339V, VAL406G, VAL408G, VAL413G, VAL649G, VAL9V
• G-X: ALA571G, ALA577G, ALA97X, ARG95X, ASN552G, ASN92X, ASP51X, ASP556G, GLN49X, GLU100X, GLU538G, GLU539G, GLU557G, GLU576G, GLU57X, GLU93X, GLY46X, GLY48X, GLY560G, HIS558G, HIS578G, HIS87X, HIS88X, ILE535G, LEU554G, LEU559G, LEU94X, LYS50X, LYS561G, LYS567G, LYS569G, LYS61X, MET44X, MET47X, MET530G, PHE542G, PHE550G, PHE565G, PHE90X, PRO568G, PRO570G, SER534G, SER549G, SER562G, THR548G, TYR53X, TYR555G, TYR91X, VAL43X, VAL45X, VAL96X
• H-I: ARG19I, GLU121I, GLY124H, LEU120H, LYS128I, PHE116H, PRO106H, THR123H
• P-Q: ALA100Q, ALA138Q, ALA139Q, ALA163Q, ALA30Q, ALA52Q, ALA53Q, ALA66Q, ALA91Q, ARG127Q, ARG48Q, ARG56Q, ARG809P, ARG810P, ARG821P, ASN135Q, ASN819P, ASN825P, ASP162Q, ASP26Q, ASP35Q, ASP43Q, ASP46Q, ASP92Q, ASP95Q, CYS154Q, CYS815P, GLN36Q, GLN817P, GLU132Q, GLU161Q, GLU29Q, GLU49Q, GLU63Q, GLU70Q, GLU808P, GLU811P, GLU86Q, GLU94Q, GLY124Q, GLY125Q, GLY126Q, GLY160Q, GLY55Q, GLY90Q, GLY99Q, HIS159Q, HIS828P, ILE133Q, ILE153Q, ILE157Q, ILE34Q, ILE42Q, ILE813P, ILE816P, ILE838P, ILE97Q, LEU104Q, LEU117Q, LEU120Q, LEU121Q, LEU47Q, LEU64Q, LEU834P, LEU841P, LEU842P, LEU88Q, LYS102Q, LYS44Q, LYS87Q, LYS89Q, MET136Q, MET54Q, MET67Q, MET824P, MET832P, MET83Q, MET98Q, PHE101Q, PHE116Q, PHE128Q, PHE140Q, PHE27Q, PHE31Q, PHE51Q, PHE80Q, PHE814P, PHE823P, PHE835P, PHE836P, PHE84Q, PRO141Q, PRO830P, PRO840P, PRO93Q, SER812P, SER822P, THR123Q, THR129Q, THR158Q, THR50Q, TRP137Q, TRP829P, TRP831P, TYR155Q, TYR818P, VAL103Q, VAL144Q, VAL156Q, VAL33Q, VAL59Q, VAL820P, VAL826P, VAL96Q
• P-R: ALA112R, ALA13R, ALA34R, ALA36R, ALA44R, ALA718P, ALA729P, ALA731P, ALA784P, ALA789P, ALA792P, ARG19R, ARG35R, ARG723P, ARG725P, ARG779P, ARG793P, ARG795P, ARG800P, ARG804P, ARG810P, ARG92R, ASN40R, ASN43R, ASN47R, ASN728P, ASN99R, ASP32R, ASP86R, ASP95R, ASP9R, CYS794P, GLN130R, GLN29R, GLN39R, GLN722P, GLN736P, GLN791P, GLN81R, GLU116R, GLU120R, GLU121R, GLU122R, GLU124R, GLU125R, GLU12R, GLU45R, GLU734P, GLU785P, GLU802P, GLU85R, GLU89R, GLU97R, GLY100R, GLY115R, GLY31R, GLY38R, GLY796P, GLY82R, GLY90R, GLY98R, HIS109R, HIS145R, ILE146R, ILE33R, ILE46R, ILE732P, ILE786P, ILE787P, LEU107R, LEU111R, LEU114R, LEU126R, LEU16R, LEU37R, LEU727P, LEU747P, LEU783P, LEU798P, LEU91R, LYS117R, LYS128R, LYS144R, LYS721P, LYS79R, LYS96R, MET118R, MET127R, MET147R, MET738P, MET799P, MET806P, PHE142R, PHE14R, PHE17R, PHE737P, PHE797P, PHE84R, PHE87R, PHE94R, PRO41R, PRO733P, SER148R, SER730P, THR113R, THR119R, THR42R, THR788P, THR790P, THR83R, TYR139R, TYR724P, TYR803P, VAL110R, VAL123R, VAL143R, VAL149R, VAL726P, VAL801P, VAL807P, VAL88R, VAL93R
• P-0: ALA260, ARG1470, ARG280, ARG3350, ARG654P, ASN410P, ASP10, ASP240, ASP250, ASP30, GLN3540, GLN647P, GLU20, GLU3340, GLU40, GLU411P, GLU537P, GLU539P, GLU629P, GLU631P, GLU655P, GLY1460, GLY632P, GLY633P, GLY635P, GLY639P, ILE3410, LYS544P, LYS636P, LYS637P, LYS640P, LYS641P, LYS642P, PRO529P, SER1410, SER1450, SER3440, SER3480, SER3500, THR3510, TRP3400
• 7-8: ALA1747, ARG1777, ARG1968, ARG2568, ARG398, ARG628, ASN1117, ASP1797, ASP1848, ASP1878, ASP2867, CYS2857, GLU1958, GLU2707, GLU2708, GLY1978, GLY2687, GLY2688, GLY638, HIS1737, HIS408, ILE2678, ILE2877, ILE648, ILE757, LEU1107, LEU658, LYS1137, LYS1918, LYS2847, MET2697, MET2698, PHE2668, PRO1127, PRO1727, SER1998, SER2657, SER2658, THR1948, THR2038, TYR1988, VAL2018
• 7-9: ALA2049, ALA3217, ARG1477, ARG2069, ARG2907, ARG3727, ARG399, ARG629, ASP2449, ASP2867, ASP2887, CYS2857, GLN2469, GLN419, GLN599, GLU1677, GLU2059, GLU2079, GLU2419, GLY1467, GLY1687, GLY2459, GLY429, GLY469, GLY639, HIS409, ILE2089, ILE2489, ILE2827, ILE2877, ILE2897, ILE3277, ILE649, LEU1717, LEU2429, LYS2847, LYS2917, LYS3267, LYS619, MET2837, MET3257, MET3557, MET449, PHE2009, PRO2439, PRO3227, SER1999, SER3237, SER609, THR1487, THR1497, THR2029, THR2039, THR3247, THR3517, TYR1437, TYR1667, TYR1697, TYR2409, TYR2947, VAL2019, VAL2479, VAL439, VAL459
• 8-9: ALA1748, ARG1778, ARG1969, ARG2569, ARG399, ARG629, ASN1118, ASP1798, ASP1849, ASP1879, ASP2868, CYS2858, GLU1959, GLU2708, GLU2709, GLY1979, GLY2688, GLY2689, GLY639, HIS1738, HIS409, ILE2679, ILE2878, ILE649, ILE758, LEU1108, LEU659, LYS1138, LYS1919, LYS2848, MET2698, MET2699, PHE2669, PRO1128, PRO1728, SER1999, SER2658, SER2659, THR1949, THR2039, TYR1989, VAL2019
• 8-V: ALA204V, ALA3218, ARG1478, ARG206V, ARG2908, ARG3728, ARG39V, ARG62V, ASP244V, ASP2868, ASP2888, CYS2858, GLN246V, GLN41V, GLN59V, GLU1678, GLU205V, GLU207V, GLU241V, GLY1468, GLY1688, GLY245V, GLY42V, GLY46V, GLY63V, HIS40V, ILE208V, ILE248V, ILE2828, ILE2878, ILE2898, ILE3278, ILE64V, LEU1718, LEU242V, LYS2848, LYS2918, LYS3268, LYS61V, MET2838, MET3258, MET3558, MET44V, PHE200V, PRO243V, PRO3228, SER199V, SER3238, SER60V, THR1488, THR1498, THR202V, THR203V, THR3248, THR3518, TYR1438, TYR1668, TYR1698, TYR240V, TYR2948, VAL201V, VAL247V, VAL43V, VAL45V
• 9-V: ALA1749, ARG1779, ARG196V, ARG256V, ARG39V, ARG62V, ASN1119, ASP1799, ASP184V, ASP187V, ASP2869, CYS2859, GLU195V, GLU2709, GLU270V, GLY197V, GLY2689, GLY268V, GLY63V, HIS1739, HIS40V, ILE267V, ILE2879, ILE64V, ILE759, LEU1109, LEU65V, LYS1139, LYS191V, LYS2849, MET2699, MET269V, PHE266V, PRO1129, PRO1729, SER199V, SER2659, SER265V, THR194V, THR203V, TYR198V, VAL201V
• 9-W: ALA204W, ALA3219, ARG1479, ARG206W, ARG2909, ARG3729, ARG39W, ARG62W, ASP244W, ASP2869, ASP2889, CYS2859, GLN246W, GLN41W, GLN59W, GLU1679, GLU205W, GLU207W, GLU241W, GLY1469, GLY1689, GLY245W, GLY42W, GLY46W, GLY63W, HIS40W, ILE208W, ILE248W, ILE2829, ILE2879, ILE2899, ILE3279, ILE64W, LEU1719, LEU242W, LYS2849, LYS2919, LYS3269, LYS61W, MET2839, MET3259, MET3559, MET44W, PHE200W, PRO243W, PRO3229, SER199W, SER3239, SER60W, THR1489, THR1499, THR202W, THR203W, THR3249, THR3519, TYR1439, TYR1669, TYR1699, TYR240W, TYR2949, VAL201W, VAL247W, VAL43W, VAL45W
• V-W: ALA174V, ARG177V, ARG196W, ARG256W, ARG39W, ARG62W, ASN111V, ASP179V, ASP184W, ASP187W, ASP286V, CYS285V, GLU195W, GLU270V, GLU270W, GLY197W, GLY268V, GLY268W, GLY63W, HIS173V, HIS40W, ILE267W, ILE287V, ILE64W, ILE75V, LEU110V, LEU65W, LYS113V, LYS191W, LYS284V, MET269V, MET269W, PHE266W, PRO112V, PRO172V, SER199W, SER265V, SER265W, THR194W, THR203W, TYR198W, VAL201W
• V-X: ALA204X, ALA321V, ARG206X, ARG290V, ARG372V, ARG62X, ASP244X, ASP286V, ASP288V, ASP292V, CYS285V, GLN246X, GLN354V, GLN41X, GLU167V, GLU205X, GLU207X, GLU241X, GLY168V, GLY245X, GLY42X, GLY46X, GLY63X, ILE208X, ILE282V, ILE287V, ILE289V, ILE327V, ILE64X, LEU242X, LEU293V, LEU346V, LYS284V, LYS291V, LYS326V, LYS61X, MET190X, MET283V, MET325V, MET355V, MET44X, PHE200X, PHE352V, PRO243X, PRO322V, SER199X, SER239X, SER323V, SER60X, THR148V, THR202X, THR203X, THR324V, THR351V, TYR133V, TYR166V, TYR169V, TYR240X, TYR294V, VAL201X, VAL209X, VAL43X, VAL45X
• W-X: ARG39X, ARG62X, ASP179W, ASP184X, ASP187X, GLU195X, GLU270W, GLY268W, GLY63X, HIS40X, ILE64X, LEU110W, LEU65X, LYS191X, LYS284W, MET269W, PHE266W, PRO112W, PRO264W, SER265W, THR202X, THR203X, VAL201X
• W-Y: ALA204Y, ARG290W, ASP244Y, ASP286W, ASP288W, GLU205Y, GLU207Y, ILE287W, LYS291W, THR202Y, THR203Y
• X-Y: ASP286X, GLU195Y, GLU270Y, HIS173X, LYS113X, LYS191Y
• X-Z: ALA204Z, ARG290X, ASP244Z, ASP286X, ASP288X, ASP292X, GLU205Z, GLU207Z, GLU241Z, LYS291X, THR202Z
• Y-Z: ARG62Z, GLU270Y
• Y-0: ALA2040, ARG290Y, ASP2440, ASP286Y, ASP288Y, ASP292Y, GLU2050, GLU2070, GLU2410, LYS291Y, THR2020
• Z-0: ARG620, GLU270Z
• Z-1: ARG621, ASP286Z, ASP288Z, GLU167Z, GLU2071, LYS611
• 0-1: ARG1160, ARG1770, ARG1961, ARG2561, ASN2521, ASP2860, ASP2880, GLU1070, GLU1951, GLU2531, GLU2701, HIS1730, LYS1130, LYS1911
• 0-2: ARG392, ARG622, ASP2860, ASP2880, ASP2920, GLU1670, GLY632, HIS402, LYS2910, LYS612
• 1-2: ARG1962, ARG392, ASP2861, GLU1952, GLU2701, GLU2702, HIS1731, LYS1131, LYS1912
• 1-3: ARG623, ASP2861, ASP2881, GLU1671, GLU2073, LYS613
• 2-3: ARG393, ASP2862, GLU1953, GLU2702, GLU2703, HIS1732, LYS1132, LYS1913
• 2-4: ARG2902, ARG624, ASP2444, ASP2862, ASP2882, GLU1672, GLU2054, GLU2074, LYS614, THR3242
• 3-4: ARG394, ASP2863, GLU1954, GLU2703, GLU2704, HIS1733, LYS1133, LYS1914
• 3-5: ARG2903, ARG625, ASP2445, ASP2863, ASP2883, GLU1673, GLU2055, GLU2075, LYS615
• 4-5: ARG395, ASP2864, GLU1955, GLU2704, GLU2705, HIS1734, LYS1134, LYS1915