1M57

structure of cytochrome c oxidase from rhodobacter sphaeroides (eq(i-286) mutant))

• Total interactions analyzed: 28
• Total true interactions: 18
• Strongest Interaction:
  • Chains: C-G
  • Int. Res.: 13
  • Norm. En. per Res.: -4.8267
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-104.8235	-44.3273	-929.741	-1078.8918	325	88	31	42601	3	51	54
A-C	-45.955	-102.2309	-673.937	-822.1228	252	61	24	30237	6	20	20
A-D	0.0	0.0	-30.2924	-30.2924	55	0	1	1953	0	5	3
A-I	-4.5557	-17.1023	-50.5115	-72.1695	42	2	0	1887	1	11	9
A-J	0.0	0.0	-20.0761	-20.0761	15	0	0	808	0	0	1
B-C	-9.2133	0.0	-20.6457	-29.859	20	5	1	1621	0	3	2
B-G	0.0	0.0	-0.0033	-0.0033	2	0	0	2	0	2	1
B-I	0.0	21.4437	-60.6798	-39.2361	58	3	0	2935	0	23	18
B-J	0.0	-3.1243	-32.4493	-35.5736	27	7	1	1897	0	3	2
C-D	-25.2816	3.6932	-117.535	-139.1233	65	19	4	5071	0	8	9
C-G	-5.9446	-34.4034	-22.3989	-62.7469	13	7	0	736	2	4	3
C-I	0.0	0.0	-7.1742	-7.1742	13	0	0	362	0	5	4
C-J	0.0	0.9965	-32.6859	-31.6894	30	3	0	1650	0	3	3
G-H	-127.1766	-44.7761	-920.98	-1092.9326	324	82	32	42273	3	51	55
G-I	-34.6749	-94.6912	-676.867	-806.2331	254	58	25	29878	6	20	20
G-J	0.0	0.0	-30.3327	-30.3327	54	0	1	2008	0	5	3
H-I	-8.3107	0.0	-20.7967	-29.1074	20	6	1	1620	0	3	2
I-J	-16.2369	2.6816	-123.672	-137.2273	63	15	3	5100	0	7	9

Interface residues

• A-B: ALA103B, ALA117B, ALA213B, ALA223B, ALA230B, ALA236B, ALA261B, ALA306A, ALA338A, ALA356A, ALA368A, ALA384A, ALA404A, ALA489A, ALA491A, ALA51B, ALA65A, ALA66B, ALA79B, ALA84A, ALA92B, ARG171B, ARG187B, ARG234B, ARG35B, ARG408A, ARG476A, ARG481A, ARG482A, ARG82B, ARG87B, ARG93B, ASN125B, ASN163A, ASN170B, ASN494A, ASN532A, ASN87A, ASN88B, ASN91A, ASN96A, ASN97B, ASP169B, ASP188B, ASP214B, ASP229B, ASP271A, ASP407A, ASP412A, ASP485A, ASP58B, CYS252B, CYS256B, CYS64A, CYS88A, GLN126B, GLN127B, GLN142B, GLN165A, GLN228B, GLN237B, GLN251B, GLN265A, GLN276A, GLN344A, GLN345A, GLN37B, GLN403A, GLN44B, GLN477A, GLN53B, GLU101B, GLU128B, GLU175B, GLU177B, GLU182A, GLU189B, GLU254B, GLU376A, GLU488A, GLU533A, GLU66A, GLU85B, GLU86A, GLY116B, GLY162A, GLY164A, GLY168B, GLY169A, GLY171A, GLY212B, GLY225B, GLY233B, GLY250B, GLY257B, GLY269A, GLY270A, GLY312A, GLY339A, GLY360A, GLY372A, GLY373A, GLY386A, GLY394A, GLY395A, GLY39B, GLY40B, GLY42B, GLY475A, GLY478A, GLY59A, GLY59B, GLY92A, HIS217B, HIS260B, HIS277A, HIS411A, HIS472A, HIS534A, HIS55B, HIS84B, HIS93A, HIS96B, ILE102B, ILE106B, ILE109B, ILE111B, ILE115B, ILE129B, ILE170A, ILE216B, ILE258B, ILE265B, ILE302A, ILE310A, ILE355A, ILE361A, ILE363A, ILE367A, ILE375A, ILE399A, ILE484A, ILE54B, ILE61B, ILE64B, ILE65B, ILE68B, ILE70B, ILE76B, ILE99A, LEU100B, LEU112B, LEU120B, LEU123B, LEU174A, LEU178A, LEU191B, LEU192B, LEU235B, LEU238B, LEU255B, LEU274A, LEU314A, LEU340A, LEU342A, LEU377A, LEU382A, LEU385A, LEU388A, LEU390A, LEU401A, LEU474A, LEU57B, LEU62B, LEU74B, LEU75B, LEU77B, LEU94A, LYS227B, LYS307A, LYS308A, LYS362A, LYS378A, LYS454A, LYS86B, LYS89B, MET160B, MET172B, MET263B, MET316A, MET335A, MET349A, MET350A, MET353A, MET370A, MET381A, MET479A, MET63A, PHE118B, PHE124B, PHE190B, PHE224B, PHE249B, PHE264A, PHE305A, PHE311A, PHE364A, PHE387A, PHE389A, PHE391A, PHE43B, PHE461A, PHE469A, PHE473A, PHE490A, PHE60B, PHE71B, PHE83B, PHE94B, PRO108B, PRO121B, PRO164B, PRO174B, PRO176A, PRO177A, PRO222B, PRO232B, PRO264B, PRO266A, PRO272A, PRO309A, PRO315A, PRO358A, PRO36B, PRO38B, PRO45B, PRO470A, PRO480A, PRO487A, PRO58A, PRO90A, PRO91B, SER119B, SER168A, SER173B, SER179A, SER181A, SER218B, SER253B, SER259B, SER267A, SER341A, SER346A, SER365A, SER374A, SER402A, SER405A, SER46B, SER83A, SER98B, THR100A, THR105B, THR180A, THR211B, THR220B, THR337A, THR343A, THR352A, THR369A, THR392A, THR397A, THR413A, THR41B, THR492A, THR69B, THR73B, THR89A, THR95B, TRP104B, TRP143B, TRP145B, TRP172A, TRP219B, TRP366A, TRP371A, TRP458A, TRP493A, TRP56B, TRP81B, TRP95A, TYR175A, TYR262B, TYR275A, TYR313A, TYR336A, TYR347A, TYR409A, TYR410A, TYR415A, TYR483A, TYR486A, TYR78B, VAL107B, VAL110B, VAL113B, VAL122B, VAL210B, VAL215B, VAL221B, VAL226B, VAL231B, VAL273A, VAL354A, VAL357A, VAL393A, VAL396A, VAL400A, VAL406A, VAL50B, VAL60A, VAL72B, VAL80B, VAL85A, VAL90B, VAL97A
• A-C: ALA105C, ALA130A, ALA134A, ALA148A, ALA153A, ALA155A, ALA159A, ALA190A, ALA193A, ALA194C, ALA199A, ALA200C, ALA205A, ALA205C, ALA217A, ALA21C, ALA236A, ALA242A, ALA247A, ALA249A, ALA25C, ALA2C, ALA32C, ALA332A, ALA338A, ALA4C, ALA96C, ARG137A, ARG14A, ARG19A, ARG216A, ARG257A, ARG76C, ARG80C, ASN139A, ASN140A, ASN196C, ASN201C, ASN207A, ASN214A, ASN258A, ASN25A, ASN6C, ASP132A, ASP188A, ASP256A, ASP271A, ASP61C, ASP70C, ASP8C, GLN265A, GLN276A, GLN344A, GLN553A, GLU182A, GLU548A, GLU552A, GLU65C, GLU90C, GLY110C, GLY129A, GLY149A, GLY15A, GLY184A, GLY195C, GLY199C, GLY248A, GLY24C, GLY260A, GLY268A, GLY269A, GLY270A, GLY31C, GLY339A, GLY57C, GLY78C, GLY82C, HIS104C, HIS10C, HIS195A, HIS26A, HIS277A, HIS37C, HIS3C, HIS549A, HIS71C, HIS7C, ILE11C, ILE128A, ILE16C, ILE191A, ILE197C, ILE202A, ILE206A, ILE209A, ILE239A, ILE250A, ILE278A, ILE29A, ILE84C, ILE87C, LEU12C, LEU141A, LEU145A, LEU152A, LEU189A, LEU196A, LEU203A, LEU213A, LEU238A, LEU240A, LEU241A, LEU243A, LEU246A, LEU253A, LEU254A, LEU274A, LEU279A, LEU29C, LEU340A, LEU34C, LEU554A, LEU77C, LEU79C, LEU85C, LYS103C, LYS556A, LYS5C, MET109C, MET133A, MET138A, MET204C, MET208A, MET20C, MET215A, MET222A, MET22A, MET252A, MET28C, MET335A, MET36C, MET43C, MET55C, MET88C, MET92C, PHE101C, PHE102C, PHE135A, PHE17A, PHE192A, PHE193C, PHE19C, PHE202C, PHE203C, PHE208C, PHE212A, PHE21A, PHE233A, PHE259A, PHE263A, PHE264A, PHE26C, PHE281A, PHE282A, PHE30C, PHE328A, PHE348A, PHE551A, PHE83C, PHE86C, PHE93C, PHE94C, PHE98C, PRO108C, PRO111C, PRO114C, PRO122C, PRO131A, PRO136A, PRO13C, PRO14C, PRO160A, PRO18C, PRO218A, PRO244A, PRO266A, PRO272A, PRO555A, PRO73C, SER100C, SER113C, SER142A, SER151A, SER156A, SER15C, SER183A, SER186A, SER200A, SER22C, SER23A, SER267A, SER341A, SER39C, SER60C, SER66C, SER89C, SER95C, THR150A, THR187A, THR18A, THR210A, THR211A, THR24A, THR251A, THR255A, THR261A, THR262A, THR54C, THR550A, THR64C, TRP144A, TRP17C, TRP20A, TRP237A, TRP280A, TRP331A, TRP35C, TRP58C, TRP59C, TRP81C, TRP97C, TRP99C, TYR107C, TYR143A, TYR146A, TYR185A, TYR198C, TYR275A, TYR9C, VAL147A, VAL154A, VAL23C, VAL245A, VAL273A, VAL27C, VAL33C, VAL51C, VAL62C, VAL63C, VAL74C, VAL75C, VAL91C
• A-D: ALA217A, ALA33D, ALA40D, ARG216A, ARG557A, ASN214A, ASN48D, ASP15D, GLN18D, GLN19D, GLN344A, GLU20D, GLY219A, GLY25D, ILE16D, ILE209A, ILE37D, LEU213A, LEU240A, LEU241A, LEU41D, LEU44D, LEU554A, LYS21D, MET14D, MET215A, MET220A, MET222A, MET29D, PHE212A, PHE233A, PHE23D, PHE26D, PHE281A, PHE328A, PHE348A, PRO131A, PRO218A, SER341A, THR17D, THR210A, THR211A, THR221A, THR22D, THR343A, TRP230A, TRP237A, TRP32D, TRP331A, TYR318A, TYR347A, VAL27D, VAL30D, VAL325A, VAL329A
• A-I: ALA154I, ALA65A, ARG161I, ARG162I, ARG76I, ASN159I, ASN160I, ASN163A, ASP163I, ASP8I, GLN165A, GLN265A, GLU158I, GLU182A, GLU235I, GLU66A, GLU69A, GLY161A, GLY162A, GLY164A, GLY184A, GLY268A, HIS157I, HIS67A, LEU155I, LEU68A, PRO160A, PRO177A, PRO234I, PRO266A, PRO73I, SER181A, SER183A, SER267A, SER70A, THR180A, THR233I, THR72I, TRP166I, TYR185A, VAL156I, VAL74I
• A-J: ALA11J, ASP15J, GLN265A, GLU20J, GLY12J, GLY268A, GLY269A, GLY270A, ILE16J, MET14J, PRO266A, SER13J, SER267A, THR17J, VAL10J
• B-C: ALA236B, ARG234B, GLN209B, GLN237B, GLU112C, GLY110C, GLY233B, ILE115C, ILE116C, ILE129B, LEU235B, LYS103C, MET109C, PRO111C, PRO114C, PRO232B, SER113C, THR211B, TYR107C, VAL231B
• B-G: ARG14G, GLU153B
• B-I: ALA165B, ALA213B, ALA2I, ARG161I, ARG226I, ARG229I, ARG76I, ASN159I, ASP169B, ASP214B, ASP70I, GLN142B, GLN228I, GLU148B, GLU153B, GLU157B, GLU235I, GLU65I, GLU68I, GLY146B, GLY167B, GLY168B, GLY230I, GLY69I, HIS231I, HIS3I, HIS71I, ILE154B, ILE225I, ILE258B, LEU67I, LYS137B, LYS236I, PHE156B, PHE232I, PRO13I, PRO14I, PRO150B, PRO164B, PRO234I, PRO73I, SER155B, SER163B, SER66I, THR139B, THR166B, THR233I, THR64I, TRP143B, TRP145B, TYR141B, TYR144B, TYR147B, TYR159B, TYR287B, VAL215B, VAL227I, VAL63I
• B-J: ALA11J, ALA213B, ALA236B, ARG234B, GLN209B, GLN237B, GLU148B, GLY12J, GLY212B, GLY233B, GLY8J, HIS9J, LEU235B, LYS137B, PRO150B, PRO232B, SER13J, THR135B, THR139B, THR211B, TYR141B, TYR149B, VAL10J, VAL136B, VAL138B, VAL210B, VAL231B
• C-D: ALA11D, ALA24D, ALA2C, ALA33D, ALA34D, ALA45D, ALA49D, ALA4C, ARG76C, ARG80C, ASN48D, ASN6C, ASP15D, ASP70C, ASP8C, GLN18D, GLN19D, GLU20D, GLU68C, GLY12D, GLY25D, GLY69C, GLY78C, GLY82C, GLY8D, HIS3C, HIS71C, HIS7C, HIS9D, ILE16D, ILE37D, ILE42D, ILE84C, LEU106C, LEU41D, LEU44D, LEU77C, LEU85C, LYS21D, LYS236C, LYS5C, MET14D, MET88C, MET92C, PHE23D, PHE256C, PHE26D, PRO73C, SER13D, SER95C, THR17D, THR22D, THR72C, TRP245C, TRP264C, TRP81C, TYR107C, TYR9C, VAL10D, VAL27D, VAL30D, VAL38D, VAL74C, VAL75C, VAL91C
• C-G: ARG557G, GLU123C, GLU558G, GLY124C, GLY219G, ILE119C, ILE125C, ILE126C, LEU554G, LYS556G, PRO111C, PRO122C, PRO218G
• C-I: ALA4I, ASN6I, ASP8I, GLU112C, GLY110C, GLY38C, HIS157I, HIS37C, HIS3I, HIS7I, ILE119C, LYS5I, PRO111C
• C-J: ALA11J, ALA190C, ALA194C, ASN196C, ASP15J, GLN18J, GLU112C, GLU123C, GLU20J, GLY110C, GLY124C, GLY192C, GLY195C, GLY8J, HIS9J, ILE115C, ILE116C, ILE125C, ILE126C, ILE16J, MET109C, MET14J, PHE191C, PRO111C, PRO114C, PRO122C, SER113C, SER13J, THR17J, VAL10J
• G-H: ALA103H, ALA117H, ALA213H, ALA223H, ALA230H, ALA236H, ALA261H, ALA306G, ALA338G, ALA356G, ALA368G, ALA384G, ALA404G, ALA489G, ALA491G, ALA51H, ALA65G, ALA66H, ALA79H, ALA84G, ALA92H, ARG171H, ARG187H, ARG234H, ARG35H, ARG408G, ARG476G, ARG481G, ARG482G, ARG82H, ARG87H, ARG93H, ASN125H, ASN163G, ASN170H, ASN494G, ASN532G, ASN87G, ASN88H, ASN91G, ASN96G, ASN97H, ASP169H, ASP188H, ASP214H, ASP229H, ASP271G, ASP407G, ASP412G, ASP485G, ASP58H, CYS252H, CYS256H, CYS64G, CYS88G, GLN126H, GLN127H, GLN142H, GLN165G, GLN228H, GLN237H, GLN251H, GLN265G, GLN276G, GLN344G, GLN345G, GLN37H, GLN403G, GLN44H, GLN477G, GLN53H, GLU101H, GLU128H, GLU175H, GLU177H, GLU182G, GLU189H, GLU254H, GLU376G, GLU488G, GLU533G, GLU66G, GLU85H, GLU86G, GLY116H, GLY162G, GLY162H, GLY164G, GLY168H, GLY169G, GLY171G, GLY212H, GLY225H, GLY233H, GLY250H, GLY257H, GLY269G, GLY270G, GLY312G, GLY339G, GLY360G, GLY372G, GLY373G, GLY386G, GLY394G, GLY395G, GLY39H, GLY40H, GLY42H, GLY475G, GLY478G, GLY59G, GLY59H, GLY92G, HIS217H, HIS260H, HIS277G, HIS411G, HIS472G, HIS534G, HIS55H, HIS84H, HIS93G, HIS96H, ILE102H, ILE106H, ILE109H, ILE111H, ILE115H, ILE129H, ILE170G, ILE216H, ILE258H, ILE265H, ILE302G, ILE310G, ILE355G, ILE361G, ILE363G, ILE367G, ILE375G, ILE399G, ILE484G, ILE54H, ILE61H, ILE64H, ILE65H, ILE68H, ILE70H, ILE76H, ILE99G, LEU100H, LEU112H, LEU120H, LEU123H, LEU174G, LEU178G, LEU191H, LEU192H, LEU235H, LEU238H, LEU255H, LEU274G, LEU314G, LEU340G, LEU342G, LEU377G, LEU382G, LEU385G, LEU388G, LEU390G, LEU401G, LEU474G, LEU57H, LEU62H, LEU74H, LEU75H, LEU77H, LEU94G, LYS227H, LYS307G, LYS308G, LYS362G, LYS378G, LYS454G, LYS86H, LYS89H, MET160H, MET172H, MET263H, MET316G, MET335G, MET349G, MET350G, MET353G, MET370G, MET381G, MET479G, PHE118H, PHE124H, PHE190H, PHE224H, PHE249H, PHE264G, PHE305G, PHE311G, PHE364G, PHE389G, PHE391G, PHE43H, PHE461G, PHE469G, PHE473G, PHE490G, PHE60H, PHE71H, PHE83H, PHE94H, PRO108H, PRO121H, PRO164H, PRO174H, PRO176G, PRO177G, PRO222H, PRO232H, PRO264H, PRO266G, PRO272G, PRO309G, PRO315G, PRO358G, PRO36H, PRO38H, PRO45H, PRO470G, PRO480G, PRO487G, PRO58G, PRO90G, PRO91H, SER119H, SER168G, SER173H, SER179G, SER181G, SER218H, SER253H, SER259H, SER267G, SER341G, SER346G, SER365G, SER374G, SER402G, SER405G, SER46H, SER83G, SER98H, THR100G, THR105H, THR180G, THR211H, THR220H, THR337G, THR343G, THR352G, THR369G, THR392G, THR397G, THR413G, THR41H, THR492G, THR69H, THR73H, THR89G, THR95H, TRP104H, TRP143H, TRP145H, TRP172G, TRP219H, TRP366G, TRP371G, TRP458G, TRP493G, TRP56H, TRP81H, TRP95G, TYR175G, TYR262H, TYR275G, TYR313G, TYR336G, TYR347G, TYR409G, TYR410G, TYR415G, TYR483G, TYR486G, TYR78H, VAL107H, VAL110H, VAL113H, VAL122H, VAL176H, VAL215H, VAL221H, VAL226H, VAL231H, VAL273G, VAL354G, VAL357G, VAL393G, VAL396G, VAL400G, VAL406G, VAL50H, VAL60G, VAL72H, VAL80H, VAL85G, VAL90H, VAL97G
• G-I: ALA105I, ALA130G, ALA134G, ALA148G, ALA153G, ALA155G, ALA159G, ALA190G, ALA193G, ALA194I, ALA199G, ALA200I, ALA205G, ALA205I, ALA217G, ALA21I, ALA236G, ALA242G, ALA247G, ALA249G, ALA25I, ALA2I, ALA32I, ALA332G, ALA338G, ALA4I, ALA96I, ARG137G, ARG14G, ARG19G, ARG216G, ARG257G, ARG76I, ARG80I, ASN139G, ASN140G, ASN196I, ASN201I, ASN207G, ASN214G, ASN258G, ASN25G, ASN6I, ASP132G, ASP188G, ASP256G, ASP271G, ASP61I, ASP8I, GLN265G, GLN276G, GLN344G, GLN553G, GLU182G, GLU548G, GLU552G, GLU65I, GLU90I, GLY110I, GLY129G, GLY149G, GLY15G, GLY184G, GLY192I, GLY195I, GLY199I, GLY204G, GLY248G, GLY24I, GLY260G, GLY268G, GLY269G, GLY270G, GLY31I, GLY339G, GLY38I, GLY57I, GLY78I, GLY82I, HIS104I, HIS10I, HIS195G, HIS26G, HIS277G, HIS37I, HIS3I, HIS549G, HIS71I, HIS7I, ILE11I, ILE128G, ILE16I, ILE191G, ILE197I, ILE202G, ILE206G, ILE209G, ILE239G, ILE250G, ILE278G, ILE29G, ILE84I, ILE87I, LEU12I, LEU141G, LEU145G, LEU152G, LEU189G, LEU196G, LEU203G, LEU213G, LEU238G, LEU240G, LEU241G, LEU243G, LEU246G, LEU253G, LEU254G, LEU274G, LEU279G, LEU29I, LEU340G, LEU34I, LEU554G, LEU77I, LEU79I, LEU85I, LYS103I, LYS556G, LYS5I, MET109I, MET133G, MET138G, MET204I, MET208G, MET20I, MET215G, MET222G, MET22G, MET252G, MET28I, MET335G, MET36I, MET43I, MET55I, MET88I, MET92I, PHE101I, PHE102I, PHE135G, PHE17G, PHE192G, PHE193I, PHE19I, PHE202I, PHE203I, PHE208I, PHE212G, PHE21G, PHE233G, PHE259G, PHE263G, PHE264G, PHE26I, PHE281G, PHE282G, PHE30I, PHE328G, PHE348G, PHE551G, PHE83I, PHE86I, PHE93I, PHE94I, PHE98I, PRO108I, PRO111I, PRO114I, PRO122I, PRO131G, PRO136G, PRO13I, PRO14I, PRO160G, PRO18I, PRO218G, PRO244G, PRO266G, PRO272G, PRO555G, PRO73I, SER100I, SER113I, SER142G, SER151G, SER156G, SER15I, SER183G, SER186G, SER200G, SER22I, SER23G, SER267G, SER341G, SER39I, SER60I, SER66I, SER89I, SER95I, THR150G, THR187G, THR18G, THR210G, THR211G, THR24G, THR251G, THR255G, THR261G, THR262G, THR54I, THR550G, THR64I, TRP144G, TRP17I, TRP20G, TRP237G, TRP280G, TRP331G, TRP35I, TRP58I, TRP59I, TRP81I, TRP97I, TRP99I, TYR107I, TYR143G, TYR146G, TYR185G, TYR198I, TYR275G, TYR9I, VAL147G, VAL154G, VAL23I, VAL245G, VAL273G, VAL27I, VAL33I, VAL51I, VAL62I, VAL63I, VAL74I, VAL75I, VAL91I
• G-J: ALA217G, ALA33J, ARG216G, ARG557G, ASN214G, ASN48J, ASP15J, GLN18J, GLN19J, GLN344G, GLU20J, GLY219G, GLY25J, ILE16J, ILE209G, ILE37J, LEU213G, LEU240G, LEU241G, LEU41J, LEU44J, LEU554G, LYS21J, MET14J, MET215G, MET220G, MET222G, MET29J, PHE212G, PHE233G, PHE23J, PHE26J, PHE281G, PHE328G, PHE348G, PRO131G, PRO218G, SER341G, THR17J, THR210G, THR211G, THR221G, THR22J, THR343G, TRP230G, TRP237G, TRP32J, TRP331G, TYR318G, TYR347G, VAL27J, VAL30J, VAL325G, VAL329G
• H-I: ALA236H, ARG234H, GLN209H, GLN228H, GLN237H, GLU112I, GLY110I, GLY233H, ILE115I, ILE116I, LEU235H, LYS103I, MET109I, PRO111I, PRO114I, PRO232H, SER113I, THR211H, TYR107I, VAL231H
• I-J: ALA11J, ALA24J, ALA2I, ALA34J, ALA45J, ALA49J, ALA4I, ARG76I, ARG80I, ASN48J, ASN6I, ASP15J, ASP70I, ASP8I, GLN18J, GLN19J, GLU20J, GLU68I, GLY12J, GLY25J, GLY69I, GLY78I, GLY8J, HIS3I, HIS71I, HIS7I, HIS9J, ILE16J, ILE37J, ILE42J, ILE84I, LEU106I, LEU41J, LEU44J, LEU77I, LEU85I, LYS21J, LYS236I, LYS5I, MET14J, MET88I, MET92I, PHE102I, PHE23J, PHE256I, PHE26J, PRO73I, SER13J, SER95I, THR17J, THR22J, THR72I, TRP245I, TRP81I, TYR107I, TYR9I, VAL10J, VAL27J, VAL30J, VAL38J, VAL74I, VAL75I, VAL91I