1M1J

crystal structure of native chicken fibrinogen with two different bound ligands

• Total interactions analyzed: 45
• Total true interactions: 19
• Strongest Interaction:
  • Chains: B-I
  • Int. Res.: 49
  • Norm. En. per Res.: -3.8192
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-79.569	-122.9944	499.284	296.7206	320	91	38	43661	10	92	92
A-C	-49.7945	-152.0692	984.634	782.7703	232	55	20	24780	10	49	47
A-D	0.0	-10.1689	733.332	723.1631	32	4	0	852	0	7	11
A-E	-69.2422	11.3597	550.91	493.0275	50	41	0	8125	0	16	13
A-F	0.0	0.0	-6.4999	-6.4999	12	0	0	168	0	2	3
B-C	-121.0634	-132.7136	631.86	378.0829	339	48	39	36636	8	80	78
B-D	-63.5635	10.7766	525.423	472.6361	49	35	0	8172	0	16	11
B-E	0.0	0.0	-46.0075	-46.0075	18	0	0	1024	0	2	4
B-F	-3.8786	-16.7713	-37.4572	-58.1071	36	4	0	1627	1	5	7
B-I	-40.1379	-24.9763	-122.029	-187.1431	49	5	0	3958	3	15	14
C-D	0.0	0.0	-0.1796	-0.1796	8	0	0	28	0	0	0
C-E	-6.8037	-15.163	-41.6075	-63.5742	41	4	0	2165	2	5	7
C-F	0.0	0.8634	1288.13	1288.9934	54	28	5	7428	0	7	10
C-G	-26.1919	5.8102	-127.945	-148.3267	48	10	0	4584	3	10	7
D-E	-109.5354	-110.1613	446.525	226.8284	329	114	36	44479	7	90	92
D-F	-61.6035	-166.3233	1026.12	798.1932	235	73	20	24515	10	50	46
E-F	-148.2805	-96.3623	579.823	335.1803	350	73	43	37383	8	75	80
E-J	-41.5681	-22.9828	-95.5148	-160.0658	49	12	0	4048	3	15	14
F-H	-39.5639	2.2365	-131.368	-168.6955	50	9	0	4548	2	9	7

Interface residues

• A-B: ALA102A, ALA110B, ALA128A, ALA136A, ALA161A, ALA167A, ALA175B, ALA189A, ALA190B, ALA192B, ALA431B, ALA67B, ALA75A, ARG108B, ARG117A, ARG118A, ARG119A, ARG126A, ARG133A, ARG137B, ARG150A, ARG160A, ARG168A, ARG171B, ARG174B, ARG199B, ARG209A, ARG260B, ARG269B, ARG419B, ARG51A, ARG66A, ARG71A, ARG86A, ASN124B, ASN128B, ASN132A, ASN139A, ASN140B, ASN148B, ASN156B, ASN161B, ASN164B, ASN165B, ASN181A, ASN189B, ASN215A, ASN266B, ASN280B, ASN69A, ASN79A, ASN85A, ASP104B, ASP106A, ASP114B, ASP127B, ASP139B, ASP141B, ASP154A, ASP156A, ASP160B, ASP171A, ASP175A, ASP178B, ASP180A, ASP193A, ASP196B, ASP197A, ASP213A, ASP262B, ASP429B, ASP437B, ASP57A, ASP58A, ASP60A, ASP66B, ASP68A, ASP76A, CYS162A, CYS166A, CYS198B, CYS202B, CYS50A, CYS70B, CYS81B, GLN103A, GLN125A, GLN130A, GLN134B, GLN136B, GLN138A, GLN142A, GLN144A, GLN173A, GLN183A, GLN185B, GLN188A, GLN194B, GLN199A, GLN261B, GLN53A, GLN61A, GLN72A, GLN73A, GLN78A, GLN88B, GLN94B, GLU143A, GLU146B, GLU147A, GLU150B, GLU152A, GLU152B, GLU177A, GLU188B, GLU218A, GLU295B, GLU86B, GLU95B, GLY110A, GLY164A, GLY178A, GLY263B, GLY268B, GLY279B, GLY294B, GLY418B, GLY423B, GLY424B, GLY434B, GLY438B, GLY49A, GLY54A, GLY68B, GLY69B, GLY84B, GLY98A, HIS154B, HIS181B, HIS185A, HIS195A, HIS433B, ILE120A, ILE126B, ILE134A, ILE141A, ILE142B, ILE143B, ILE155A, ILE157A, ILE158B, ILE159A, ILE166B, ILE177B, ILE182A, ILE184B, ILE191B, ILE192A, ILE55A, ILE56A, ILE63B, ILE67A, ILE70A, ILE88A, ILE92A, LEU102B, LEU105A, LEU105B, LEU116A, LEU123A, LEU130B, LEU137A, LEU144B, LEU151A, LEU153B, LEU162B, LEU170B, LEU173B, LEU180B, LEU186A, LEU187B, LEU203A, LEU206A, LEU211A, LEU74A, LEU80B, LEU87B, LEU91B, LEU92B, LEU95A, LEU99A, LYS106B, LYS111B, LYS124A, LYS129B, LYS132B, LYS135A, LYS135B, LYS138B, LYS149A, LYS158A, LYS159B, LYS163A, LYS176A, LYS182B, LYS183B, LYS184A, LYS186B, LYS207A, LYS212A, LYS283B, LYS32A, LYS432B, LYS80A, LYS82A, LYS93B, LYS96A, LYS99B, MET119B, MET125B, MET148A, MET151B, MET194A, MET208A, MET430B, MET52A, PHE112B, PHE170A, PHE198A, PHE267B, PRO167B, PRO196A, PRO201B, PRO210A, PRO217A, PRO47A, PRO65B, PRO82B, SER113A, SER113B, SER116B, SER140A, SER145B, SER165A, SER168B, SER169A, SER169B, SER179B, SER190A, SER191A, SER200B, SER204A, SER214A, SER264B, SER427B, SER450B, SER48A, SER64A, SER77A, SER84A, THR114A, THR115B, THR117B, THR118B, THR122A, THR129A, THR133B, THR149B, THR187A, THR193B, THR195B, THR200A, THR201A, THR202A, THR205A, THR425B, THR435B, THR59A, THR83B, THR90B, THR91A, THR97B, TRP321B, TRP422B, TRP428B, TYR109A, TYR120B, TYR122B, TYR147B, TYR155B, TYR157B, TYR172A, TYR179A, TYR197B, TYR420B, TYR421B, TYR426B, TYR63A, TYR64B, TYR81A, VAL101B, VAL109B, VAL112A, VAL121A, VAL123B, VAL127A, VAL131A, VAL131B, VAL145A, VAL146A, VAL153A, VAL172B, VAL174A, VAL176B, VAL203B, VAL216A, VAL265B, VAL79B, VAL89A, VAL98B
• A-C: ALA102A, ALA102C, ALA129C, ALA136A, ALA161A, ALA167A, ALA26C, ALA50C, ALA75A, ARG117A, ARG118A, ARG119A, ARG126A, ARG133A, ARG150A, ARG160A, ARG33C, ARG51A, ARG66A, ARG71A, ARG86A, ARG95C, ASN105C, ASN108A, ASN117C, ASN119C, ASN132A, ASN139A, ASN30C, ASN52C, ASN62A, ASN69A, ASN79A, ASN85A, ASN98C, ASP106A, ASP112C, ASP154A, ASP156A, ASP27C, ASP37C, ASP41A, ASP57A, ASP58A, ASP60A, ASP68A, ASP76A, CYS135C, CYS139C, CYS162A, CYS166A, CYS23C, CYS46A, CYS50A, GLN103A, GLN104A, GLN108C, GLN109C, GLN123C, GLN126C, GLN130A, GLN130C, GLN136C, GLN138A, GLN142A, GLN144A, GLN48C, GLN49C, GLN53A, GLN62C, GLN65A, GLN72A, GLN73A, GLN78A, GLN81C, GLN84C, GLU104C, GLU107A, GLU115A, GLU132C, GLU137C, GLU143A, GLU147A, GLU152A, GLU39C, GLU42C, GLU44C, GLU58C, GLU80C, GLU90A, GLU91C, GLU92C, GLU97C, GLY110A, GLY164A, GLY24C, GLY38C, GLY43A, GLY45C, GLY49A, GLY55C, GLY98A, HIS103C, HIS111A, HIS114C, HIS134C, ILE100C, ILE107C, ILE115C, ILE120A, ILE121C, ILE128C, ILE134A, ILE141A, ILE155A, ILE157A, ILE159A, ILE25C, ILE43C, ILE55A, ILE56A, ILE57C, ILE61C, ILE64C, ILE67A, ILE67C, ILE70A, ILE79C, ILE88A, ILE89C, ILE90C, ILE92A, ILE93C, ILE94A, ILE94C, LEU101C, LEU105A, LEU110C, LEU116A, LEU123A, LEU124C, LEU131C, LEU137A, LEU151A, LEU211A, LEU34C, LEU40C, LEU41C, LEU47C, LEU60C, LEU74A, LEU82C, LEU95A, LEU99A, LYS120C, LYS124A, LYS125C, LYS127C, LYS135A, LYS140C, LYS158A, LYS163A, LYS45A, LYS65C, LYS80A, LYS82A, LYS85C, LYS87C, LYS88C, LYS96A, MET113C, MET116C, MET148A, MET194A, MET208A, MET52A, PHE170A, PHE28C, PHE29C, PRO138C, PRO47A, PRO69C, SER113A, SER118C, SER133C, SER140A, SER165A, SER48A, SER53C, SER56C, SER64A, SER77A, SER78C, SER84A, SER86C, THR106C, THR111C, THR114A, THR122A, THR122C, THR129A, THR21C, THR22C, THR35C, THR36C, THR44A, THR51C, THR54C, THR59A, THR66C, THR83A, THR83C, THR91A, THR99C, TRP42A, TYR109A, TYR172A, TYR179A, TYR32C, TYR59C, TYR63A, TYR68C, TYR81A, TYR96C, VAL112A, VAL121A, VAL127A, VAL131A, VAL145A, VAL153A, VAL87A, VAL89A
• A-D: ARG51A, ARG51D, CYS28A, CYS28D, CYS46A, CYS46D, CYS50A, CYS50D, GLN53A, GLN53D, GLU31A, GLU31D, GLY49A, GLY49D, GLY54A, GLY54D, LYS29A, LYS29D, LYS32A, LYS32D, LYS45A, LYS45D, PRO47A, PRO47D, SER27A, SER27D, SER48A, SER48D, THR44A, THR44D, TRP34A, TRP34D
• A-E: ALA67E, ARG51A, ASN33A, ASP39A, ASP41A, ASP66E, ASP75E, CYS28A, CYS37A, CYS46A, CYS70E, CYS81E, CYS85E, GLU31A, GLU76E, GLU86E, GLY43A, GLY49A, GLY68E, GLY69E, GLY78E, GLY84E, HIS72E, ILE36A, ILE55A, ILE63E, LEU74E, LEU77E, LEU80E, LEU87E, LYS29A, LYS32A, LYS45A, LYS71E, MET52A, PRO35A, PRO47A, PRO65E, PRO73E, PRO82E, SER27A, SER48A, THR44A, THR59A, THR83E, TRP34A, TRP42A, TYR64E, VAL38A, VAL79E
• A-F: ASP40A, ASP41A, CYS19F, CYS46A, GLU6F, GLY43A, ILE56A, LYS45A, PHE15F, SER17F, THR44A, TRP42A
• B-C: ALA102C, ALA110B, ALA129C, ALA143C, ALA175B, ALA190B, ALA192B, ALA204B, ALA26C, ALA270B, ALA282B, ALA50C, ARG103B, ARG108B, ARG137B, ARG171B, ARG174B, ARG199B, ARG206C, ARG214B, ARG221B, ARG242B, ARG269B, ARG276B, ARG33C, ARG419B, ARG95C, ASN105C, ASN117C, ASN119C, ASN124B, ASN128B, ASN140B, ASN148B, ASN156B, ASN161B, ASN164B, ASN165B, ASN189B, ASN207B, ASN207C, ASN266B, ASN280B, ASN30C, ASN52C, ASP104B, ASP107B, ASP112C, ASP114B, ASP127B, ASP141B, ASP141C, ASP160B, ASP163B, ASP178B, ASP196B, ASP199C, ASP218B, ASP221C, ASP222C, ASP235B, ASP27C, ASP291B, ASP37C, CYS135C, CYS139C, CYS198B, CYS19C, CYS202B, CYS206B, CYS23C, CYS290B, CYS81B, CYS85B, GLN108C, GLN109C, GLN121B, GLN123C, GLN126C, GLN130C, GLN134B, GLN136C, GLN176C, GLN185B, GLN194B, GLN195C, GLN210C, GLN233B, GLN48C, GLN49C, GLN62C, GLN73C, GLN77C, GLN81C, GLN88B, GLN94B, GLU104C, GLU132C, GLU137C, GLU144C, GLU146B, GLU147C, GLU152B, GLU188B, GLU202C, GLU213C, GLU225B, GLU225C, GLU228B, GLU231C, GLU273B, GLU295B, GLU39C, GLU42C, GLU44C, GLU58C, GLU80C, GLU86B, GLU91C, GLU92C, GLU95B, GLU97C, GLY213B, GLY214C, GLY216C, GLY223B, GLY224B, GLY229C, GLY24C, GLY268B, GLY277B, GLY279B, GLY38C, GLY45C, GLY55C, GLY84B, HIS103C, HIS114C, HIS134C, HIS154B, HIS181B, HIS217C, HIS63C, ILE100C, ILE107C, ILE115C, ILE121C, ILE126B, ILE128C, ILE142B, ILE143B, ILE145C, ILE158B, ILE166B, ILE177B, ILE184B, ILE191B, ILE208B, ILE219B, ILE231B, ILE232B, ILE25C, ILE281B, ILE43C, ILE57C, ILE61C, ILE64C, ILE67C, ILE79C, ILE89C, ILE90C, ILE93C, ILE94C, LEU101C, LEU102B, LEU105B, LEU110C, LEU124C, LEU130B, LEU131C, LEU144B, LEU162B, LEU166C, LEU170B, LEU173B, LEU179C, LEU180B, LEU187B, LEU194C, LEU198C, LEU218C, LEU228C, LEU40C, LEU41C, LEU46C, LEU47C, LEU60C, LEU75C, LEU82C, LEU87B, LEU91B, LEU92B, LYS106B, LYS111B, LYS120C, LYS125C, LYS127C, LYS129B, LYS132B, LYS135B, LYS138B, LYS140C, LYS159B, LYS170C, LYS175C, LYS182B, LYS183B, LYS186B, LYS212C, LYS222B, LYS232C, LYS283B, LYS287B, LYS288B, LYS31C, LYS432B, LYS65C, LYS85C, LYS88C, LYS93B, LYS96B, LYS99B, MET113C, MET116C, MET119B, MET125B, MET151B, MET229B, PHE112B, PHE168C, PHE178C, PHE215C, PHE226C, PHE237B, PHE267B, PHE278B, PHE28C, PHE29C, PRO138C, PRO167B, PRO201B, PRO209B, PRO20C, PRO220C, PRO234B, PRO236B, PRO240B, PRO69C, PRO76C, PRO82B, SER113B, SER116B, SER118C, SER145B, SER168B, SER169B, SER177C, SER179B, SER17C, SER201C, SER205B, SER212B, SER219C, SER264B, SER53C, SER56C, SER78C, SER86C, THR106C, THR111C, THR115B, THR117B, THR118B, THR122C, THR133B, THR142C, THR149B, THR193B, THR195B, THR21C, THR223C, THR224C, THR226B, THR22C, THR239B, THR35C, THR36C, THR51C, THR54C, THR66C, THR83B, THR83C, THR89B, THR90B, THR97B, THR99C, TRP227C, TYR120B, TYR122B, TYR147B, TYR155B, TYR181C, TYR18C, TYR197B, TYR211C, TYR220B, TYR230B, TYR241B, TYR289B, TYR296B, TYR32C, TYR382B, TYR59C, TYR64B, TYR68C, TYR96C, VAL101B, VAL109B, VAL123B, VAL131B, VAL172B, VAL176B, VAL180C, VAL203B, VAL209C, VAL210B, VAL211B, VAL265B, VAL98B
• B-D: ALA67B, ARG51D, ASN33D, ASP39D, ASP41D, ASP66B, ASP75B, CYS28D, CYS37D, CYS46D, CYS70B, CYS81B, CYS85B, GLU31D, GLU76B, GLU86B, GLY43D, GLY49D, GLY68B, GLY69B, GLY78B, GLY84B, HIS72B, ILE36D, ILE55D, ILE63B, LEU74B, LEU77B, LEU80B, LEU87B, LYS29D, LYS32D, LYS45D, LYS71B, MET52D, PRO35D, PRO47D, PRO65B, PRO73B, PRO82B, SER27D, SER48D, THR44D, THR83B, TRP34D, TRP42D, TYR64B, VAL38D, VAL79B
• B-E: ASP66B, ASP66E, ASP75B, ASP75E, GLU76B, GLU76E, GLY78B, GLY78E, ILE63B, ILE63E, LEU74B, LEU74E, LEU77B, LEU77E, PRO65B, PRO65E, TYR64B, TYR64E
• B-F: ALA26F, ARG14F, ARG33F, ASN30F, ASP12F, CYS19F, CYS23F, CYS81B, CYS85B, GLN88B, GLU13F, GLU76B, GLU86B, GLU95B, GLY16F, GLY24F, GLY84B, LEU11F, LEU77B, LEU80B, LEU87B, LEU91B, LEU92B, LYS93B, LYS96B, LYS99B, PHE15F, PHE29F, PRO20F, PRO82B, THR21F, THR22F, THR83B, THR89B, THR90B, TYR18F
• B-I: ALA361B, ALA413B, ALA414B, ARG369B, ARG395B, ARG3I, ARG410B, ASN368B, ASN409B, ASN415B, ASP387B, ASP402B, ASP436B, ASP437B, CYS398B, CYS411B, GLN363B, GLN397B, GLU367B, GLU401B, GLY1I, GLY388B, GLY403B, GLY434B, GLY438B, GLY446B, HIS2I, HIS374B, HIS412B, HIS433B, LEU364B, LEU390B, LYS396B, LYS400B, MET371B, MET442B, PRO4I, SER399B, SER447B, THR370B, THR372B, THR391B, THR435B, TRP389B, TRP448B, TYR365B, TYR408B, TYR426B, VAL440B
• C-D: CYS19C, GLY43D, GLY49D, ILE56D, PHE15C, SER17C, THR22C, THR44D
• C-E: ALA26C, ARG14C, ARG33C, ARG5C, ASN30C, ASP12C, CYS19C, CYS23C, CYS81E, CYS85E, CYS8C, CYS9C, GLN88E, GLU13C, GLU76E, GLU86E, GLU95E, GLY16C, GLY24C, GLY84E, ILE10C, LEU11C, LEU74E, LEU77E, LEU80E, LEU87E, LEU91E, LEU92E, LYS93E, LYS96E, LYS99E, PHE15C, PHE29C, PRO20C, PRO82E, THR21C, THR22C, THR83E, THR89E, THR90E, TYR18C
• C-F: ALA26C, ALA26F, ARG14C, ARG14F, ARG5C, ARG5F, ASN7C, ASN7F, ASP12C, ASP12F, ASP27C, ASP27F, CYS19C, CYS19F, CYS23C, CYS23F, CYS8C, CYS8F, CYS9C, CYS9F, GLU13C, GLU13F, GLU6C, GLU6F, GLY16C, GLY16F, GLY24C, GLY24F, ILE10C, ILE10F, ILE25C, ILE25F, LEU11C, LEU11F, LYS31C, LYS31F, PHE15C, PHE15F, PHE28C, PHE28F, PHE29C, PHE29F, PRO20C, PRO20F, SER17C, SER17F, THR21C, THR21F, THR22C, THR22F, THR4C, TYR18C, TYR18F, TYR32F
• C-G: ALA327C, ALA341C, ALA370C, ARG338C, ARG356C, ARG375C, ARG3G, ASN294C, ASN321C, ASN325C, ASN337C, ASN361C, ASN365C, ASP297C, ASP298C, ASP301C, ASP320C, ASP330C, ASP364C, CYS326C, CYS339C, GLN329C, GLU323C, GLU328C, GLY1G, GLY296C, GLY324C, GLY331C, GLY342C, GLY366C, HIS307C, HIS340C, HIS343C, ILE368C, LYS302C, MET336C, PHE293C, PHE295C, PHE322C, PRO2G, PRO4G, SER300C, SER362C, THR305C, TRP376C, TYR304C, TYR354C, TYR363C
• D-E: ALA102D, ALA110E, ALA128D, ALA136D, ALA161D, ALA167D, ALA175E, ALA189D, ALA190E, ALA192E, ALA431E, ALA67E, ALA75D, ARG103E, ARG108E, ARG117D, ARG118D, ARG119D, ARG126D, ARG133D, ARG137E, ARG150D, ARG160D, ARG168D, ARG171E, ARG174E, ARG199E, ARG209D, ARG260E, ARG269E, ARG419E, ARG51D, ARG66D, ARG71D, ARG86D, ASN124E, ASN128E, ASN132D, ASN139D, ASN140E, ASN148E, ASN156E, ASN161E, ASN164E, ASN165E, ASN181D, ASN189E, ASN215D, ASN266E, ASN280E, ASN69D, ASN79D, ASN85D, ASP104E, ASP106D, ASP107E, ASP127E, ASP139E, ASP141E, ASP154D, ASP156D, ASP160E, ASP163E, ASP171D, ASP175D, ASP178E, ASP180D, ASP193D, ASP196E, ASP197D, ASP213D, ASP262E, ASP429E, ASP437E, ASP57D, ASP58D, ASP60D, ASP66E, ASP68D, ASP76D, CYS162D, CYS166D, CYS198E, CYS202E, CYS50D, CYS70E, CYS81E, CYS85E, GLN103D, GLN121E, GLN125D, GLN130D, GLN134E, GLN136E, GLN138D, GLN142D, GLN144D, GLN173D, GLN183D, GLN185E, GLN188D, GLN194E, GLN199D, GLN261E, GLN53D, GLN61D, GLN72D, GLN73D, GLN78D, GLN88E, GLN94E, GLU100D, GLU115D, GLU143D, GLU146E, GLU147D, GLU150E, GLU152D, GLU152E, GLU177D, GLU188E, GLU218D, GLU295E, GLU86E, GLY101D, GLY110D, GLY164D, GLY178D, GLY263E, GLY268E, GLY279E, GLY294E, GLY418E, GLY423E, GLY424E, GLY434E, GLY438E, GLY49D, GLY54D, GLY68E, GLY69E, GLY84E, GLY98D, HIS154E, HIS181E, HIS185D, HIS195D, HIS219D, HIS433E, ILE120D, ILE126E, ILE134D, ILE141D, ILE143E, ILE155D, ILE157D, ILE158E, ILE159D, ILE166E, ILE177E, ILE182D, ILE184E, ILE191E, ILE192D, ILE55D, ILE56D, ILE63E, ILE67D, ILE70D, ILE88D, ILE92D, LEU102E, LEU105D, LEU105E, LEU116D, LEU123D, LEU130E, LEU137D, LEU144E, LEU151D, LEU153E, LEU162E, LEU170E, LEU173E, LEU180E, LEU186D, LEU187E, LEU203D, LEU206D, LEU211D, LEU74D, LEU80E, LEU87E, LEU91E, LEU92E, LEU95D, LEU99D, LYS106E, LYS111E, LYS124D, LYS129E, LYS132E, LYS135D, LYS135E, LYS138E, LYS149D, LYS158D, LYS159E, LYS163D, LYS176D, LYS182E, LYS183E, LYS184D, LYS186E, LYS207D, LYS212D, LYS283E, LYS432E, LYS80D, LYS82D, LYS93E, LYS96D, LYS99E, MET119E, MET125E, MET148D, MET151E, MET194D, MET208D, MET430E, MET52D, PHE112E, PHE170D, PHE198D, PHE220D, PHE267E, PRO100E, PRO167E, PRO196D, PRO201E, PRO210D, PRO217D, PRO47D, PRO65E, PRO82E, SER113D, SER113E, SER116E, SER140D, SER145E, SER165D, SER168E, SER169D, SER169E, SER179E, SER190D, SER191D, SER200E, SER204D, SER214D, SER264E, SER427E, SER450E, SER48D, SER64D, SER77D, SER84D, THR114D, THR115E, THR117E, THR118E, THR122D, THR129D, THR133E, THR149E, THR187D, THR193E, THR195E, THR200D, THR201D, THR202D, THR205D, THR425E, THR435E, THR59D, THR83E, THR89E, THR90E, THR91D, THR97E, TRP321E, TRP422E, TRP428E, TRP448E, TYR109D, TYR120E, TYR122E, TYR147E, TYR155E, TYR157E, TYR172D, TYR179D, TYR197E, TYR420E, TYR421E, TYR426E, TYR63D, TYR64E, TYR81D, VAL101E, VAL109E, VAL112D, VAL121D, VAL123E, VAL127D, VAL131D, VAL131E, VAL145D, VAL146D, VAL153D, VAL172E, VAL174D, VAL176E, VAL203E, VAL216D, VAL265E, VAL79E, VAL89D, VAL98E
• D-F: ALA102D, ALA102F, ALA129F, ALA136D, ALA161D, ALA167D, ALA26F, ALA50F, ALA75D, ARG117D, ARG118D, ARG119D, ARG126D, ARG133D, ARG150D, ARG160D, ARG168D, ARG33F, ARG51D, ARG66D, ARG71D, ARG86D, ARG95F, ASN105F, ASN108D, ASN117F, ASN119F, ASN132D, ASN139D, ASN30F, ASN52F, ASN62D, ASN69D, ASN79D, ASN85D, ASN98F, ASP106D, ASP112F, ASP154D, ASP156D, ASP27F, ASP37F, ASP41D, ASP57D, ASP58D, ASP60D, ASP68D, ASP76D, CYS135F, CYS139F, CYS162D, CYS166D, CYS23F, CYS46D, CYS50D, GLN103D, GLN104D, GLN108F, GLN109F, GLN123F, GLN126F, GLN130D, GLN130F, GLN136F, GLN138D, GLN142D, GLN144D, GLN48F, GLN53D, GLN62F, GLN65D, GLN72D, GLN73D, GLN78D, GLN81F, GLN84F, GLU104F, GLU107D, GLU115D, GLU132F, GLU137F, GLU143D, GLU147D, GLU152D, GLU39F, GLU42F, GLU44F, GLU58F, GLU71F, GLU80F, GLU90D, GLU91F, GLU92F, GLU97F, GLY110D, GLY164D, GLY24F, GLY38F, GLY43D, GLY45F, GLY49D, GLY54D, GLY55F, GLY98D, HIS103F, HIS111D, HIS114F, HIS134F, HIS219D, ILE100F, ILE107F, ILE115F, ILE120D, ILE121F, ILE128F, ILE134D, ILE141D, ILE155D, ILE157D, ILE159D, ILE25F, ILE43F, ILE55D, ILE56D, ILE57F, ILE61F, ILE64F, ILE67D, ILE67F, ILE70D, ILE79F, ILE88D, ILE89F, ILE90F, ILE92D, ILE93F, ILE94D, ILE94F, LEU101F, LEU105D, LEU110F, LEU116D, LEU123D, LEU124F, LEU131F, LEU137D, LEU151D, LEU186D, LEU211D, LEU34F, LEU40F, LEU41F, LEU46F, LEU47F, LEU60F, LEU74D, LEU82F, LEU95D, LEU99D, LYS120F, LYS124D, LYS125F, LYS127F, LYS135D, LYS140F, LYS149D, LYS158D, LYS163D, LYS45D, LYS65F, LYS80D, LYS82D, LYS85F, LYS87F, LYS88F, MET113F, MET116F, MET148D, MET52D, PHE170D, PHE28F, PHE29F, PRO138F, PRO210D, PRO47D, PRO69F, SER113D, SER118F, SER133F, SER140D, SER165D, SER169D, SER48D, SER53F, SER64D, SER70F, SER77D, SER78F, SER84D, SER86F, THR106F, THR111F, THR114D, THR122D, THR122F, THR129D, THR21F, THR22F, THR35F, THR36F, THR44D, THR51F, THR54F, THR59D, THR66F, THR83D, THR83F, THR91D, THR99F, TRP42D, TYR109D, TYR179D, TYR32F, TYR59F, TYR63D, TYR68F, TYR81D, TYR96F, VAL112D, VAL121D, VAL127D, VAL131D, VAL145D, VAL87D, VAL89D
• E-F: ALA102F, ALA110E, ALA129F, ALA143F, ALA175E, ALA190E, ALA192E, ALA204E, ALA26F, ALA270E, ALA282E, ALA50F, ARG103E, ARG108E, ARG137E, ARG171E, ARG174E, ARG199E, ARG206F, ARG214E, ARG221E, ARG242E, ARG269E, ARG276E, ARG33F, ARG419E, ARG5F, ARG95F, ASN105F, ASN117F, ASN119F, ASN124E, ASN128E, ASN140E, ASN148E, ASN156E, ASN161E, ASN164E, ASN165E, ASN189E, ASN207E, ASN207F, ASN266E, ASN280E, ASN30F, ASN52F, ASN7F, ASN98F, ASP104E, ASP107E, ASP112F, ASP114E, ASP127E, ASP141E, ASP141F, ASP160E, ASP163E, ASP178E, ASP196E, ASP199F, ASP218E, ASP221F, ASP222F, ASP235E, ASP27F, ASP291E, ASP37F, CYS135F, CYS139F, CYS198E, CYS19F, CYS202E, CYS206E, CYS23F, CYS290E, CYS81E, CYS85E, CYS8F, CYS9F, GLN108F, GLN109F, GLN121E, GLN123F, GLN126F, GLN130F, GLN134E, GLN136E, GLN136F, GLN146F, GLN176F, GLN185E, GLN194E, GLN195F, GLN210F, GLN233E, GLN48F, GLN49F, GLN62F, GLN73F, GLN77F, GLN81F, GLN84F, GLN88E, GLN94E, GLU104F, GLU132F, GLU137F, GLU144F, GLU146E, GLU147F, GLU152E, GLU188E, GLU202F, GLU213F, GLU225E, GLU225F, GLU228E, GLU231F, GLU273E, GLU295E, GLU39F, GLU42F, GLU44F, GLU58F, GLU6F, GLU86E, GLU91F, GLU92F, GLU95E, GLU97F, GLY213E, GLY214F, GLY216F, GLY223E, GLY224E, GLY229F, GLY24F, GLY268E, GLY277E, GLY279E, GLY294E, GLY38F, GLY45F, GLY55F, GLY84E, HIS103F, HIS114F, HIS134F, HIS181E, HIS217F, HIS63F, ILE100F, ILE107F, ILE115F, ILE121F, ILE126E, ILE128F, ILE142E, ILE145F, ILE158E, ILE166E, ILE177E, ILE184E, ILE191E, ILE208E, ILE219E, ILE231E, ILE232E, ILE25F, ILE281E, ILE43F, ILE57F, ILE61F, ILE64F, ILE67F, ILE79F, ILE89F, ILE90F, ILE93F, ILE94F, LEU101F, LEU102E, LEU105E, LEU110F, LEU124F, LEU130E, LEU131F, LEU144E, LEU162E, LEU166F, LEU170E, LEU173E, LEU179F, LEU180E, LEU187E, LEU194F, LEU198F, LEU218F, LEU228F, LEU40F, LEU41F, LEU46F, LEU47F, LEU60F, LEU75F, LEU82F, LEU87E, LEU91E, LEU92E, LYS106E, LYS111E, LYS120F, LYS125F, LYS127F, LYS129E, LYS132E, LYS135E, LYS138E, LYS140F, LYS159E, LYS170F, LYS175F, LYS182E, LYS183E, LYS186E, LYS212F, LYS222E, LYS232F, LYS283E, LYS287E, LYS288E, LYS31F, LYS432E, LYS65F, LYS72F, LYS85F, LYS88F, LYS93E, LYS96E, LYS99E, MET113F, MET116F, MET119E, MET125E, MET151E, MET229E, PHE112E, PHE168F, PHE178F, PHE215F, PHE226F, PHE237E, PHE267E, PHE278E, PHE28F, PHE29F, PRO138F, PRO167E, PRO201E, PRO209E, PRO20F, PRO220F, PRO234E, PRO236E, PRO240E, PRO65E, PRO69F, PRO82E, SER113E, SER116E, SER118F, SER145E, SER168E, SER169E, SER177F, SER179E, SER17F, SER201F, SER205E, SER212E, SER219F, SER264E, SER284E, SER53F, SER56F, SER78F, SER86F, THR106F, THR111F, THR115E, THR117E, THR118E, THR122F, THR133E, THR142F, THR149E, THR149F, THR193E, THR195E, THR21F, THR223F, THR224F, THR226E, THR22F, THR238E, THR239E, THR35F, THR36F, THR51F, THR54F, THR66F, THR83E, THR83F, THR89E, THR90E, THR97E, THR99F, TRP227F, TYR120E, TYR122E, TYR147E, TYR155E, TYR181F, TYR18F, TYR197E, TYR211F, TYR220E, TYR230E, TYR241E, TYR289E, TYR296E, TYR32F, TYR382E, TYR59F, TYR64E, TYR68F, TYR96F, VAL101E, VAL109E, VAL123E, VAL131E, VAL172E, VAL176E, VAL180F, VAL203E, VAL209F, VAL210E, VAL211E, VAL265E, VAL98E
• E-J: ALA361E, ALA413E, ALA414E, ARG369E, ARG395E, ARG3J, ARG410E, ASN368E, ASN409E, ASN415E, ASN443E, ASP387E, ASP402E, ASP436E, ASP437E, CYS398E, CYS411E, GLN363E, GLN397E, GLU367E, GLU401E, GLY1J, GLY388E, GLY403E, GLY434E, GLY446E, HIS2J, HIS374E, HIS412E, HIS433E, ILE373E, LEU364E, LEU390E, LYS396E, LYS400E, MET371E, MET442E, PRO4J, SER399E, SER447E, THR370E, THR372E, THR391E, THR435E, TRP389E, TRP448E, TYR365E, TYR408E, VAL440E
• F-H: ALA327F, ALA341F, ALA370F, ARG338F, ARG356F, ARG375F, ARG3H, ASN294F, ASN321F, ASN325F, ASN337F, ASN361F, ASN365F, ASP297F, ASP298F, ASP301F, ASP320F, ASP330F, ASP364F, CYS326F, CYS339F, GLN329F, GLU323F, GLU328F, GLY1H, GLY296F, GLY324F, GLY331F, GLY342F, GLY366F, HIS307F, HIS340F, HIS343F, ILE368F, LYS302F, MET336F, PHE293F, PHE295F, PHE322F, PRO2H, PRO4H, SER300F, SER303F, SER362F, THR305F, THR360F, TRP376F, TYR304F, TYR354F, TYR363F