1LS3

crystal structure of the complex between rabbit cytosolic serine hydroxymethyltransferase and triglu-5-formyl-tetrahydrofolate

• Total interactions analyzed: 6
• Total true interactions: 6
• Strongest Interaction:
  • Chains: A-C
  • Int. Res.: 82
  • Norm. En. per Res.: -4.0935
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-235.8049	-114.376	-1154.76	-1504.9409	374	96	30	50924	17	130	132
A-C	-23.3864	-83.1109	-229.173	-335.6703	82	7	2	8277	8	56	70
A-D	0.0	5.7476	-1.9015	3.8461	4	0	0	105	0	4	2
B-C	0.0	5.9746	-1.9912	3.9834	4	0	0	105	0	4	2
B-D	-27.722	-89.8831	-220.057	-337.662	87	8	2	7815	11	54	67
C-D	-189.2571	-102.4837	-1148.82	-1440.5608	363	98	30	50426	12	137	131

Interface residues

• A-B: ALA-10A, ALA101A, ALA101B, ALA104A, ALA104B, ALA108A, ALA108B, ALA137A, ALA137B, ALA13A, ALA13B, ALA202A, ALA202B, ALA236A, ALA236B, ALA255A, ALA255B, ALA268A, ALA268B, ALA270A, ALA270B, ALA273A, ALA273B, ALA275A, ALA275B, ALA279A, ALA279B, ALA293B, ALA339B, ALA343A, ALA343B, ALA34A, ALA34B, ALA368A, ALA368B, ALA39A, ALA39B, ALA3A, ALA3B, ALA42A, ALA42B, ALA46A, ALA46B, ARG232A, ARG232B, ARG235A, ARG235B, ARG25A, ARG25B, ARG27A, ARG27B, ARG289A, ARG289B, ARG363A, ARG363B, ARG372A, ARG372B, ARG412A, ARG412B, ARG41A, ARG41B, ARG63A, ARG63B, ARG81A, ARG81B, ASN102B, ASN24A, ASN24B, ASN266A, ASN266B, ASN294B, ASN345A, ASN345B, ASN37A, ASN37B, ASN52A, ASN52B, ASN53A, ASN53B, ASP10A, ASP10B, ASP12A, ASP12B, ASP17A, ASP17B, ASP72A, ASP72B, CYS234A, CYS234B, CYS344A, CYS344B, CYS50A, CYS50B, CYS78A, CYS78B, GLN-3A, GLN-3B, GLN261A, GLN261B, GLN26A, GLN26B, GLN278A, GLN278B, GLN288A, GLN288B, GLN290A, GLN290B, GLN4A, GLN4B, GLN62A, GLU-4A, GLU-4B, GLU111A, GLU111B, GLU141A, GLU14A, GLU14B, GLU22A, GLU22B, GLU283A, GLU283B, GLU286A, GLU286B, GLU31A, GLU31B, GLU334A, GLU334B, GLU338A, GLU338B, GLU36A, GLU36B, GLU45A, GLU45B, GLU57A, GLU57B, GLU69A, GLU69B, GLU73A, GLU73B, GLU75A, GLU75B, GLY113A, GLY113B, GLY233A, GLY233B, GLY237A, GLY237B, GLY259A, GLY259B, GLY262A, GLY262B, GLY263A, GLY263B, GLY271A, GLY271B, GLY373A, GLY373B, GLY418A, GLY418B, GLY48A, GLY48B, GLY61A, GLY66A, GLY66B, GLY67A, GLY67B, GLY98A, GLY98B, HIS-5A, HIS-5B, HIS112A, HIS112B, HIS126A, HIS126B, HIS203A, HIS203B, HIS228A, HIS228B, HIS265A, HIS265B, HIS267A, HIS267B, HIS70A, HIS70B, ILE135A, ILE135B, ILE139A, ILE139B, ILE18A, ILE18B, ILE19A, ILE19B, ILE269A, ILE269B, ILE33A, ILE33B, ILE342A, ILE342B, ILE71A, ILE71B, LEU-9A, LEU121A, LEU121B, LEU127A, LEU127B, LEU252A, LEU252B, LEU260A, LEU260B, LEU276A, LEU276B, LEU2A, LEU2B, LEU32B, LEU337B, LEU369B, LEU374B, LEU418A, LEU418B, LEU44A, LEU44B, LEU47A, LEU47B, LEU51A, LEU51B, LEU6A, LEU6B, LEU74A, LEU74B, LEU77A, LEU77B, LYS134A, LYS134B, LYS20A, LYS20B, LYS21A, LYS21B, LYS229A, LYS229B, LYS277A, LYS277B, LYS285A, LYS285B, LYS335A, LYS335B, LYS346A, LYS346B, LYS54A, LYS54B, LYS7A, LYS7B, LYS80A, LYS80B, MET1A, MET1B, MET280A, MET280B, PHE103A, PHE103B, PHE131A, PHE131B, PHE140A, PHE140B, PHE257A, PHE257B, PHE284A, PHE284B, PHE377B, PHE38A, PHE38B, PHE418A, PHE418B, PRO100A, PRO100B, PRO112A, PRO112B, PRO258A, PRO258B, PRO264A, PRO264B, PRO282A, PRO282B, PRO359B, PRO367B, PRO418A, PRO418B, PRO5A, PRO5B, PRO95A, PRO95B, SER-6A, SER-6B, SER-7A, SER-7B, SER11A, SER11B, SER136A, SER136B, SER138A, SER138B, SER175A, SER175B, SER23A, SER23B, SER251A, SER251B, SER254A, SER254B, SER341A, SER341B, SER35A, SER35B, SER371A, SER371B, SER40A, SER40B, SER49A, SER49B, SER56A, SER56B, SER97A, SER97B, SER99A, SER99B, THR107A, THR107B, THR128A, THR128B, THR138A, THR138B, THR226A, THR226B, THR227B, THR281A, THR281B, THR348B, THR370A, THR370B, THR68A, THR68B, THR76A, THR76B, TRP-8A, TRP-8B, TYR106A, TYR106B, TYR16A, TYR16B, TYR287A, TYR287B, TYR55A, TYR55B, TYR64A, TYR64B, TYR65A, TYR65B, TYR96A, TYR96B, VAL110A, VAL110B, VAL15A, VAL15B, VAL256A, VAL256B, VAL272A, VAL272B, VAL274A, VAL274B, VAL28A, VAL28B, VAL291A, VAL291B, VAL43A, VAL43B
• A-C: ALA144A, ALA144C, ALA162A, ALA162C, ALA190A, ALA190C, ALA195A, ALA195C, ARG115A, ARG115C, ARG157A, ARG157C, ARG163A, ARG163C, ASN161A, ASN161C, ASN193A, ASN193C, ASP120A, ASP120C, ASP123A, ASP123C, ASP134A, ASP134C, ASP156A, ASP156C, ASP191A, ASP191C, GLU141A, GLU141C, GLU160A, GLU160C, GLU192A, GLU192C, GLY113A, GLY113C, GLY118A, GLY118C, GLY194A, GLY194C, HIS112A, HIS112C, HIS166A, HIS166C, ILE116A, ILE116C, LEU158A, LEU158C, LEU164A, LEU164C, LYS134A, LYS134C, LYS146A, LYS146C, LYS168A, LYS168C, MET117A, MET117C, MET132A, MET132C, MET143A, MET143C, PHE131A, PHE131C, PHE140A, PHE140C, PHE165A, PHE165C, PRO112A, PRO112C, PRO167A, PRO167C, SER138A, SER138C, SER142A, SER142C, THR133A, THR133C, THR138A, THR138C, TYR145A, TYR145C
• A-D: HIS112A, HIS112D, PRO112A, PRO112D
• B-C: HIS112B, HIS112C, PRO112B, PRO112C
• B-D: ALA144B, ALA144D, ALA162B, ALA162D, ALA190D, ALA195B, ALA195D, ARG115B, ARG115D, ARG157B, ARG157D, ARG163B, ARG163D, ASN161B, ASN161D, ASN193B, ASN193D, ASP120B, ASP120D, ASP123B, ASP123D, ASP134B, ASP134D, ASP156B, ASP156D, ASP191D, GLU141B, GLU141D, GLU159B, GLU159D, GLU160B, GLU160D, GLU192B, GLU192D, GLY113B, GLY113D, GLY118B, GLY118D, GLY194B, GLY194D, HIS112B, HIS112D, HIS166B, HIS166D, ILE116B, ILE116D, ILE139B, ILE139D, LEU158B, LEU158D, LEU164B, LEU164D, LYS134B, LYS134D, LYS146B, LYS146D, LYS168B, LYS168D, MET117B, MET117D, MET132B, MET132D, MET143B, MET143D, PHE131B, PHE131D, PHE140B, PHE140D, PHE165B, PHE165D, PRO112B, PRO112D, PRO122D, PRO167B, PRO167D, SER138B, SER138D, SER142B, SER142D, THR133B, THR133D, THR138B, THR138D, TYR145B, TYR145D, VAL147B, VAL147D
• C-D: ALA-10C, ALA101C, ALA101D, ALA104C, ALA104D, ALA108C, ALA108D, ALA137C, ALA137D, ALA13C, ALA13D, ALA202C, ALA202D, ALA236C, ALA236D, ALA255C, ALA255D, ALA268C, ALA268D, ALA270C, ALA270D, ALA273C, ALA273D, ALA275C, ALA275D, ALA279C, ALA279D, ALA339D, ALA343C, ALA343D, ALA34C, ALA34D, ALA356D, ALA368C, ALA368D, ALA39C, ALA39D, ALA3C, ALA3D, ALA42C, ALA42D, ALA46C, ALA46D, ARG232C, ARG232D, ARG235C, ARG235D, ARG25C, ARG25D, ARG289C, ARG363C, ARG363D, ARG372C, ARG372D, ARG412C, ARG412D, ARG41C, ARG41D, ARG63C, ARG63D, ARG81C, ARG81D, ASN102D, ASN24C, ASN24D, ASN253C, ASN266C, ASN266D, ASN345C, ASN345D, ASN347D, ASN37C, ASN37D, ASN52C, ASN52D, ASN53C, ASN53D, ASP10C, ASP10D, ASP12C, ASP12D, ASP17C, ASP17D, ASP72C, ASP72D, CYS234C, CYS234D, CYS344C, CYS344D, CYS50C, CYS50D, CYS78C, CYS78D, GLN-3C, GLN-3D, GLN261C, GLN261D, GLN26C, GLN26D, GLN278C, GLN278D, GLN288D, GLN290D, GLN4C, GLN4D, GLN62C, GLU-4C, GLU-4D, GLU111C, GLU111D, GLU141C, GLU14C, GLU14D, GLU22C, GLU22D, GLU283C, GLU283D, GLU286C, GLU286D, GLU31C, GLU31D, GLU334C, GLU334D, GLU338C, GLU338D, GLU36C, GLU36D, GLU45C, GLU45D, GLU57C, GLU57D, GLU69C, GLU69D, GLU73C, GLU73D, GLU75C, GLU75D, GLY113C, GLY113D, GLY233C, GLY233D, GLY237C, GLY237D, GLY259C, GLY259D, GLY262C, GLY262D, GLY263C, GLY263D, GLY271C, GLY271D, GLY373C, GLY373D, GLY418C, GLY418D, GLY48C, GLY48D, GLY61C, GLY66C, GLY66D, GLY67C, GLY67D, GLY98C, GLY98D, HIS-5C, HIS-5D, HIS112C, HIS112D, HIS126C, HIS126D, HIS203C, HIS203D, HIS228C, HIS228D, HIS265C, HIS265D, HIS267C, HIS267D, HIS70C, HIS70D, ILE135C, ILE135D, ILE139C, ILE139D, ILE18C, ILE18D, ILE19C, ILE19D, ILE269C, ILE269D, ILE33C, ILE33D, ILE342C, ILE342D, ILE71C, ILE71D, LEU-9C, LEU121C, LEU127C, LEU127D, LEU252C, LEU252D, LEU260C, LEU260D, LEU276C, LEU276D, LEU2C, LEU2D, LEU32D, LEU337D, LEU374C, LEU374D, LEU418C, LEU418D, LEU44C, LEU44D, LEU47C, LEU47D, LEU51C, LEU51D, LEU6C, LEU6D, LEU74C, LEU74D, LEU77C, LEU77D, LYS134C, LYS134D, LYS20C, LYS20D, LYS21C, LYS21D, LYS229C, LYS229D, LYS277C, LYS277D, LYS285C, LYS285D, LYS335C, LYS335D, LYS346C, LYS346D, LYS54C, LYS54D, LYS7C, LYS7D, LYS80C, LYS80D, MET1C, MET1D, MET280C, MET280D, PHE103C, PHE103D, PHE131C, PHE131D, PHE140C, PHE140D, PHE257C, PHE257D, PHE284C, PHE284D, PHE38C, PHE38D, PHE418C, PHE418D, PRO100C, PRO100D, PRO112C, PRO112D, PRO258C, PRO258D, PRO264C, PRO264D, PRO282C, PRO282D, PRO367D, PRO418C, PRO418D, PRO5C, PRO5D, PRO95C, PRO95D, SER-6C, SER-6D, SER-7C, SER11C, SER11D, SER136C, SER136D, SER138C, SER138D, SER175C, SER175D, SER23C, SER23D, SER251C, SER251D, SER254C, SER254D, SER341C, SER341D, SER35C, SER35D, SER371C, SER371D, SER40C, SER40D, SER49C, SER49D, SER56C, SER56D, SER97C, SER97D, SER99C, SER99D, THR107C, THR107D, THR128C, THR128D, THR138C, THR138D, THR226C, THR226D, THR227D, THR281C, THR281D, THR348D, THR370C, THR370D, THR68C, THR68D, THR76D, TRP-8C, TYR106C, TYR106D, TYR16C, TYR16D, TYR287C, TYR287D, TYR55C, TYR55D, TYR64C, TYR64D, TYR65C, TYR65D, TYR96C, TYR96D, VAL110C, VAL110D, VAL15C, VAL15D, VAL256C, VAL256D, VAL272C, VAL272D, VAL274C, VAL274D, VAL28C, VAL28D, VAL291D, VAL43C, VAL43D