1LNQ

crystal structure of mthk at 3.3 a

• Total interactions analyzed: 28
• Total true interactions: 20
• Strongest Interaction:
  • Chains: C-F
  • Int. Res.: 76
  • Norm. En. per Res.: -3.7064
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	0.0	0.0	-49.9859	-49.9859	68	2	5	2336	0	14	10
A-C	0.0	0.0	-2.6936	-2.6936	12	0	0	181	0	0	0
A-D	0.0	0.0	-41.3419	-41.3419	63	0	6	1994	0	12	7
A-G	-49.4154	161.1801	-821.457	-709.6924	239	76	38	41229	4	97	133
A-H	-34.6935	-70.4541	-166.61	-271.7577	75	26	5	8037	8	41	42
B-C	0.0	0.0	-39.3226	-39.3226	66	0	7	2164	0	11	7
B-D	0.0	0.0	-6.6886	-6.6886	12	0	0	300	0	0	0
B-F	-69.1567	156.2052	-820.704	-733.6555	244	95	39	41746	4	99	125
B-G	-18.1881	-47.652	-180.309	-246.149	75	26	6	8142	6	40	42
C-D	0.0	0.0	-51.7361	-51.7361	68	3	8	2407	0	14	10
C-E	-49.9042	154.3684	-816.906	-712.4418	240	76	38	41119	4	97	132
C-F	-34.6427	-70.3816	-176.664	-281.6882	76	26	5	8060	8	41	42
D-E	-18.494	-48.8924	-180.721	-248.1073	75	26	5	8085	6	40	42
D-H	-65.1082	153.859	-807.659	-718.9082	244	106	39	41852	4	99	125
E-F	0.0	0.0	-40.8086	-40.8086	63	1	5	1975	0	11	9
E-G	0.0	0.0	-5.8571	-5.8571	12	0	0	294	0	0	0
E-H	0.0	0.0	-50.2124	-50.2124	62	5	7	2327	0	12	12
F-G	0.0	0.0	-51.8879	-51.8879	63	9	8	2566	0	11	12
F-H	0.0	0.0	-6.3332	-6.3332	12	0	0	306	0	0	0
G-H	0.0	0.0	-42.4318	-42.4318	61	3	6	1894	0	11	9

Interface residues

• A-B: ALA157A, ALA20B, ALA58A, ALA58B, ALA88A, ALA88B, ALA90A, ARG132A, ARG149A, ARG154A, ARG166B, ASN158A, ASP169B, ASP64A, ASP64B, GLU125A, GLY61A, GLY61B, GLY63A, GLY63B, GLY83B, GLY85B, ILE57A, ILE57B, ILE80B, ILE84B, LEU128A, LEU153A, LEU50A, LEU79B, LEU82B, LEU94A, LEU95A, LYS151A, LYS172B, MET73B, PHE159A, PHE54A, PHE87A, PRO19B, PRO67B, PRO70B, SER168B, SER66B, SER68B, THR21B, THR47A, THR56A, THR56B, THR59A, THR59B, THR69B, THR76B, TRP52A, TYR51A, TYR62A, TYR62B, TYR65A, TYR65B, TYR74B, VAL48A, VAL55A, VAL55B, VAL60A, VAL60B, VAL77B, VAL81B, VAL91A
• A-C: ALA58A, ALA58C, GLY61A, GLY61C, GLY63A, GLY63C, THR59A, THR59C, TYR62A, TYR62C, VAL60A, VAL60C
• A-D: ALA157D, ALA20A, ALA58A, ALA58D, ALA88A, ALA90D, ARG132D, ARG154D, ARG166A, ASN158D, ASP169A, ASP64A, ASP64D, GLU125D, GLY61A, GLY61D, GLY63A, GLY63D, GLY83A, GLY85A, ILE57A, ILE57D, ILE80A, ILE84A, LEU128D, LEU153D, LEU50D, LEU79A, LEU82A, LEU94D, LEU95D, LYS151D, LYS172A, MET73A, PHE159D, PHE54D, PHE87D, PRO19A, PRO67A, PRO70A, SER168A, SER66A, SER68A, THR47D, THR56A, THR59A, THR59D, THR69A, THR76A, TYR51D, TYR62A, TYR62D, TYR65A, TYR65D, TYR74A, VAL48D, VAL55A, VAL55D, VAL60A, VAL60D, VAL77A, VAL81A, VAL91D
• A-G: ALA180A, ALA180G, ALA209A, ALA209G, ALA211A, ALA211G, ALA249A, ALA249G, ALA257A, ALA257G, ARG132A, ARG132G, ARG135A, ARG135G, ARG154A, ARG179A, ARG179G, ARG206A, ARG206G, ARG213A, ARG213G, ARG221A, ARG221G, ARG237A, ARG237G, ARG241A, ARG241G, ARG262A, ARG262G, ARG263A, ARG263G, ARG298A, ARG298G, ARG308A, ARG308G, ARG329A, ARG329G, ASP184A, ASP184G, ASP188G, ASP226A, ASP226G, ASP244A, ASP244G, ASP245A, ASP245G, ASP254A, ASP254G, ASP284A, ASP284G, ASP287A, ASP287G, ASP300A, ASP300G, ASP305A, ASP305G, ASP309A, ASP309G, ASP316A, ASP316G, CYS130A, CYS130G, GLN227A, GLN227G, GLN253A, GLN253G, GLU125A, GLU125G, GLU129A, GLU129G, GLU133A, GLU133G, GLU138G, GLU210A, GLU210G, GLU212A, GLU212G, GLU215A, GLU215G, GLU248A, GLU248G, GLU258A, GLU258G, GLU259A, GLU259G, GLU266A, GLU266G, GLU301A, GLU301G, GLU326A, GLU326G, GLY236A, GLY236G, GLY246A, GLY246G, GLY290A, GLY290G, GLY295A, GLY295G, GLY297A, GLY297G, GLY299A, GLY299G, GLY315A, GLY315G, GLY320A, GLY320G, GLY322A, GLY322G, HIS117A, HIS117G, HIS286A, HIS286G, ILE120A, ILE120G, ILE182A, ILE182G, ILE207A, ILE208A, ILE208G, ILE217A, ILE217G, ILE229A, ILE229G, ILE234A, ILE234G, ILE243A, ILE243G, ILE285A, ILE285G, ILE292A, ILE292G, ILE293A, ILE293G, ILE294A, ILE294G, ILE303A, ILE303G, ILE304A, ILE304G, ILE317A, ILE317G, ILE318A, ILE318G, ILE321A, ILE321G, LEU128A, LEU128G, LEU131A, LEU131G, LEU134A, LEU134G, LEU238A, LEU238G, LEU256A, LEU256G, LEU281A, LEU281G, LEU302A, LEU302G, LEU319A, LEU319G, LYS151A, LYS151G, LYS323A, LYS323G, MET239A, MET239G, MET250A, MET250G, MET264A, MET264G, PHE232A, PHE232G, PHE251A, PHE251G, PRO231A, PRO231G, PRO268A, PRO268G, PRO306A, PRO306G, PRO307A, PRO307G, SER124A, SER124G, SER126A, SER126G, SER137A, SER137G, SER230A, SER230G, SER235A, SER235G, SER240A, SER240G, SER242A, SER242G, SER260A, SER260G, THR127A, THR127G, THR261A, THR261G, THR289A, THR289G, TYR214A, TYR214G, TYR247A, TYR247G, VAL118A, VAL118G, VAL119A, VAL119G, VAL139A, VAL139G, VAL181A, VAL181G, VAL183A, VAL183G, VAL228A, VAL228G, VAL233A, VAL233G, VAL252A, VAL252G, VAL255A, VAL255G, VAL265A, VAL265G, VAL267A, VAL280A, VAL280G, VAL288A, VAL288G, VAL291A, VAL291G, VAL296A, VAL296G
• A-H: ALA223A, ALA223H, ALA225A, ALA225H, ARG166A, ARG166H, ARG199A, ARG199H, ARG213A, ARG213H, ARG221A, ARG221H, ASN216A, ASN216H, ASP163A, ASP163H, ASP169A, ASP169H, ASP188A, ASP188H, CYS194A, CYS194H, GLN219A, GLN219H, GLU144H, GLU190A, GLU190H, GLU212A, GLU212H, GLU215A, GLU215H, GLU218A, GLU218H, GLY197A, GLY197H, GLY224A, GLY224H, HIS193A, HIS193H, ILE192A, ILE192H, ILE195A, ILE195H, ILE198A, ILE198H, ILE201A, ILE201H, ILE217A, ILE217H, LEU170A, LEU170H, LEU185A, LEU185H, LEU196A, LEU196H, LEU220A, LEU220H, LYS200A, LYS200H, MET222A, MET222H, SER168A, SER168H, SER187A, SER187H, SER189A, SER189H, THR165A, THR165H, THR191A, THR191H, TYR214A, TYR214H, VAL167A, VAL167H
• B-C: ALA157B, ALA20C, ALA58B, ALA58C, ALA88C, ALA90B, ARG132B, ARG154B, ARG166C, ASN158B, ASP169C, ASP64B, ASP64C, GLU125B, GLY61B, GLY61C, GLY63B, GLY63C, GLY83C, GLY85C, ILE57B, ILE57C, ILE80C, ILE84C, LEU128B, LEU153B, LEU26C, LEU50B, LEU79C, LEU82C, LEU94B, LEU95B, LEU98B, LYS151B, LYS172C, MET73C, PHE159B, PHE54B, PHE87B, PRO19C, PRO67C, PRO70C, SER168C, SER66C, SER68C, THR47B, THR56C, THR59B, THR59C, THR69C, THR76C, TRP52B, TYR51B, TYR62B, TYR62C, TYR65B, TYR65C, TYR74C, VAL48B, VAL55B, VAL55C, VAL60B, VAL60C, VAL77C, VAL81C, VAL91B
• B-D: ALA58B, ALA58D, GLY61B, GLY61D, GLY63B, GLY63D, THR59B, THR59D, TYR62B, TYR62D, VAL60B, VAL60D
• B-F: ALA180B, ALA180F, ALA209B, ALA209F, ALA211B, ALA211F, ALA249B, ALA249F, ALA257B, ALA257F, ARG132B, ARG132F, ARG135B, ARG135F, ARG154B, ARG154F, ARG179B, ARG179F, ARG206B, ARG206F, ARG213B, ARG213F, ARG221B, ARG221F, ARG237B, ARG237F, ARG241B, ARG241F, ARG262B, ARG262F, ARG263B, ARG263F, ARG298B, ARG298F, ARG308B, ARG308F, ARG329B, ARG329F, ASP184B, ASP184F, ASP188B, ASP226B, ASP226F, ASP244B, ASP244F, ASP245B, ASP245F, ASP254B, ASP254F, ASP284B, ASP284F, ASP287B, ASP287F, ASP300B, ASP300F, ASP305B, ASP305F, ASP309F, ASP316B, ASP316F, CYS130B, CYS130F, GLN227B, GLN227F, GLN253B, GLN253F, GLU125B, GLU125F, GLU129B, GLU129F, GLU133B, GLU133F, GLU138B, GLU138F, GLU210B, GLU210F, GLU212B, GLU212F, GLU215B, GLU215F, GLU248B, GLU248F, GLU258B, GLU258F, GLU259B, GLU259F, GLU266B, GLU266F, GLU301B, GLU301F, GLU326B, GLU326F, GLY236B, GLY236F, GLY246B, GLY246F, GLY290B, GLY290F, GLY295B, GLY295F, GLY297B, GLY297F, GLY299B, GLY299F, GLY315B, GLY315F, GLY320B, GLY320F, GLY322B, GLY322F, HIS117B, HIS117F, HIS286B, HIS286F, ILE120B, ILE120F, ILE182B, ILE182F, ILE207B, ILE207F, ILE208B, ILE208F, ILE217B, ILE217F, ILE229B, ILE229F, ILE234B, ILE234F, ILE243B, ILE243F, ILE285B, ILE285F, ILE292B, ILE292F, ILE293B, ILE293F, ILE294B, ILE294F, ILE303B, ILE303F, ILE304B, ILE304F, ILE317B, ILE317F, ILE318B, ILE318F, ILE321B, ILE321F, LEU128B, LEU128F, LEU131B, LEU131F, LEU134B, LEU134F, LEU238B, LEU238F, LEU256B, LEU256F, LEU281B, LEU281F, LEU302B, LEU302F, LEU319B, LEU319F, LYS151B, LYS151F, LYS323B, LYS323F, MET239B, MET239F, MET250B, MET250F, MET264B, MET264F, PHE232B, PHE232F, PHE251B, PHE251F, PRO231B, PRO231F, PRO268B, PRO268F, PRO306B, PRO306F, PRO307B, PRO307F, SER124B, SER124F, SER126B, SER126F, SER137B, SER137F, SER230B, SER230F, SER235B, SER235F, SER240B, SER240F, SER242B, SER242F, SER260B, SER260F, THR127B, THR127F, THR261B, THR261F, THR289B, THR289F, TYR214B, TYR214F, TYR247B, TYR247F, TYR310F, VAL118B, VAL118F, VAL119B, VAL119F, VAL139B, VAL139F, VAL181B, VAL181F, VAL183B, VAL183F, VAL205F, VAL228B, VAL228F, VAL233B, VAL233F, VAL252B, VAL252F, VAL255B, VAL255F, VAL265B, VAL265F, VAL267B, VAL267F, VAL280B, VAL280F, VAL288B, VAL288F, VAL291B, VAL291F, VAL296B, VAL296F
• B-G: ALA223B, ALA223G, ALA225B, ALA225G, ARG166B, ARG166G, ARG199B, ARG199G, ARG213B, ARG213G, ARG221B, ARG221G, ASN216B, ASN216G, ASP163B, ASP163G, ASP169B, ASP169G, ASP188B, ASP188G, CYS194B, CYS194G, GLN219B, GLN219G, GLU190B, GLU190G, GLU203G, GLU212B, GLU212G, GLU215B, GLU215G, GLU218B, GLU218G, GLY197B, GLY197G, GLY224B, GLY224G, HIS193B, HIS193G, ILE192B, ILE192G, ILE195B, ILE195G, ILE198B, ILE198G, ILE201B, ILE201G, ILE217B, ILE217G, LEU170B, LEU170G, LEU185B, LEU185G, LEU196B, LEU196G, LEU220B, LEU220G, LYS200B, LYS200G, MET222B, MET222G, SER168B, SER168G, SER187B, SER187G, SER189B, SER189G, THR165B, THR165G, THR191B, THR191G, TYR214B, TYR214G, VAL167B, VAL167G
• C-D: ALA157C, ALA20D, ALA58C, ALA58D, ALA88C, ALA88D, ALA90C, ARG132C, ARG149C, ARG154C, ARG166D, ASN158C, ASP169D, ASP64C, ASP64D, GLU125C, GLY61C, GLY61D, GLY63C, GLY63D, GLY83D, GLY85D, ILE57C, ILE57D, ILE80D, ILE84D, LEU128C, LEU153C, LEU50C, LEU79D, LEU82D, LEU94C, LEU95C, LYS151C, LYS172D, MET73D, PHE159C, PHE54C, PHE87C, PRO19D, PRO67D, PRO70D, SER168D, SER66D, SER68D, THR21D, THR47C, THR56C, THR56D, THR59C, THR59D, THR69D, THR76D, TRP52C, TYR51C, TYR62C, TYR62D, TYR65C, TYR65D, TYR74D, VAL48C, VAL55C, VAL55D, VAL60C, VAL60D, VAL77D, VAL81D, VAL91C
• C-E: ALA180C, ALA180E, ALA209C, ALA209E, ALA211C, ALA211E, ALA249C, ALA249E, ALA257C, ALA257E, ARG132C, ARG132E, ARG135C, ARG135E, ARG154C, ARG179C, ARG179E, ARG206C, ARG206E, ARG213C, ARG213E, ARG221C, ARG221E, ARG237C, ARG237E, ARG241C, ARG241E, ARG262C, ARG262E, ARG263C, ARG263E, ARG298C, ARG298E, ARG308C, ARG308E, ARG329C, ARG329E, ASP184C, ASP184E, ASP188E, ASP226C, ASP226E, ASP244C, ASP244E, ASP245C, ASP245E, ASP254C, ASP254E, ASP284C, ASP284E, ASP287C, ASP287E, ASP300C, ASP300E, ASP305C, ASP305E, ASP309C, ASP309E, ASP316C, ASP316E, CYS130C, CYS130E, GLN227C, GLN227E, GLN253C, GLN253E, GLU125C, GLU125E, GLU129C, GLU129E, GLU133C, GLU133E, GLU138E, GLU210C, GLU210E, GLU212C, GLU212E, GLU215C, GLU215E, GLU248C, GLU248E, GLU258C, GLU258E, GLU259C, GLU259E, GLU266C, GLU266E, GLU301C, GLU301E, GLU326C, GLU326E, GLY236C, GLY236E, GLY246C, GLY246E, GLY290C, GLY290E, GLY295C, GLY295E, GLY297C, GLY297E, GLY299C, GLY299E, GLY315C, GLY315E, GLY320C, GLY320E, GLY322C, GLY322E, HIS117C, HIS117E, HIS286C, HIS286E, ILE120C, ILE120E, ILE182C, ILE182E, ILE207C, ILE208C, ILE208E, ILE217C, ILE217E, ILE229C, ILE229E, ILE234C, ILE234E, ILE243C, ILE243E, ILE285C, ILE285E, ILE292C, ILE292E, ILE293C, ILE293E, ILE294C, ILE294E, ILE303C, ILE303E, ILE304C, ILE304E, ILE317C, ILE317E, ILE318C, ILE318E, ILE321C, ILE321E, LEU128C, LEU128E, LEU131C, LEU131E, LEU134C, LEU134E, LEU238C, LEU238E, LEU256C, LEU256E, LEU281C, LEU281E, LEU302C, LEU302E, LEU319C, LEU319E, LYS151C, LYS151E, LYS323C, LYS323E, MET239C, MET239E, MET250C, MET250E, MET264C, MET264E, PHE232C, PHE232E, PHE251C, PHE251E, PRO231C, PRO231E, PRO268C, PRO268E, PRO306C, PRO306E, PRO307C, PRO307E, SER124C, SER124E, SER126C, SER126E, SER137C, SER137E, SER230C, SER230E, SER235C, SER235E, SER240C, SER240E, SER242C, SER242E, SER260C, SER260E, THR127C, THR127E, THR261C, THR261E, THR289C, THR289E, TYR214C, TYR214E, TYR247C, TYR247E, VAL118C, VAL118E, VAL119C, VAL119E, VAL139C, VAL139E, VAL181C, VAL181E, VAL183C, VAL183E, VAL205C, VAL228C, VAL228E, VAL233C, VAL233E, VAL252C, VAL252E, VAL255C, VAL255E, VAL265C, VAL265E, VAL267C, VAL280C, VAL280E, VAL288C, VAL288E, VAL291C, VAL291E, VAL296C, VAL296E
• C-F: ALA223C, ALA223F, ALA225C, ALA225F, ARG166C, ARG166F, ARG199C, ARG199F, ARG213C, ARG213F, ARG221C, ARG221F, ASN216C, ASN216F, ASP163C, ASP163F, ASP169C, ASP169F, ASP188C, ASP188F, CYS194C, CYS194F, GLN219C, GLN219F, GLU144F, GLU190C, GLU190F, GLU203F, GLU212C, GLU212F, GLU215C, GLU215F, GLU218C, GLU218F, GLY197C, GLY197F, GLY224C, GLY224F, HIS193C, HIS193F, ILE192C, ILE192F, ILE195C, ILE195F, ILE198C, ILE198F, ILE201C, ILE201F, ILE217C, ILE217F, LEU170C, LEU170F, LEU185C, LEU185F, LEU196C, LEU196F, LEU220C, LEU220F, LYS200C, LYS200F, MET222C, MET222F, SER168C, SER168F, SER187C, SER187F, SER189C, SER189F, THR165C, THR165F, THR191C, THR191F, TYR214C, TYR214F, VAL167C, VAL167F
• D-E: ALA223D, ALA223E, ALA225D, ALA225E, ARG166D, ARG166E, ARG199D, ARG199E, ARG213D, ARG213E, ARG221D, ARG221E, ASN216D, ASN216E, ASP163D, ASP163E, ASP169D, ASP169E, ASP188D, ASP188E, CYS194D, CYS194E, GLN219D, GLN219E, GLU190D, GLU190E, GLU203E, GLU212D, GLU212E, GLU215D, GLU215E, GLU218D, GLU218E, GLY197D, GLY197E, GLY224D, GLY224E, HIS193D, HIS193E, ILE192D, ILE192E, ILE195D, ILE195E, ILE198D, ILE198E, ILE201D, ILE201E, ILE217D, ILE217E, LEU170D, LEU170E, LEU185D, LEU185E, LEU196D, LEU196E, LEU220D, LEU220E, LYS200D, LYS200E, MET222D, MET222E, SER168D, SER168E, SER187D, SER187E, SER189D, SER189E, THR165D, THR165E, THR191D, THR191E, TYR214D, TYR214E, VAL167D, VAL167E
• D-H: ALA180D, ALA180H, ALA209D, ALA209H, ALA211D, ALA211H, ALA249D, ALA249H, ALA257D, ALA257H, ARG132D, ARG132H, ARG135D, ARG135H, ARG154D, ARG154H, ARG179D, ARG179H, ARG206D, ARG206H, ARG213D, ARG213H, ARG221D, ARG221H, ARG237D, ARG237H, ARG241D, ARG241H, ARG262D, ARG262H, ARG263D, ARG263H, ARG298D, ARG298H, ARG308D, ARG308H, ARG329D, ARG329H, ASP184D, ASP184H, ASP188D, ASP226D, ASP226H, ASP244D, ASP244H, ASP245D, ASP245H, ASP254D, ASP254H, ASP284D, ASP284H, ASP287D, ASP287H, ASP300D, ASP300H, ASP305D, ASP305H, ASP309H, ASP316D, ASP316H, CYS130D, CYS130H, GLN227D, GLN227H, GLN253D, GLN253H, GLU125D, GLU125H, GLU129D, GLU129H, GLU133D, GLU133H, GLU138D, GLU138H, GLU210D, GLU210H, GLU212D, GLU212H, GLU215D, GLU215H, GLU248D, GLU248H, GLU258D, GLU258H, GLU259D, GLU259H, GLU266D, GLU266H, GLU301D, GLU301H, GLU326D, GLU326H, GLY236D, GLY236H, GLY246D, GLY246H, GLY290D, GLY290H, GLY295D, GLY295H, GLY297D, GLY297H, GLY299D, GLY299H, GLY315D, GLY315H, GLY320D, GLY320H, GLY322D, GLY322H, HIS117D, HIS117H, HIS286D, HIS286H, ILE120D, ILE120H, ILE182D, ILE182H, ILE207D, ILE207H, ILE208D, ILE208H, ILE217D, ILE217H, ILE229D, ILE229H, ILE234D, ILE234H, ILE243D, ILE243H, ILE285D, ILE285H, ILE292D, ILE292H, ILE293D, ILE293H, ILE294D, ILE294H, ILE303D, ILE303H, ILE304D, ILE304H, ILE317D, ILE317H, ILE318D, ILE318H, ILE321D, ILE321H, LEU128D, LEU128H, LEU131D, LEU131H, LEU134D, LEU134H, LEU238D, LEU238H, LEU256D, LEU256H, LEU281D, LEU281H, LEU302D, LEU302H, LEU319D, LEU319H, LYS151D, LYS151H, LYS323D, LYS323H, MET239D, MET239H, MET250D, MET250H, MET264D, MET264H, PHE232D, PHE232H, PHE251D, PHE251H, PRO231D, PRO231H, PRO268D, PRO268H, PRO306D, PRO306H, PRO307D, PRO307H, SER124D, SER124H, SER126D, SER126H, SER137D, SER137H, SER230D, SER230H, SER235D, SER235H, SER240D, SER240H, SER242D, SER242H, SER260D, SER260H, THR127D, THR127H, THR261D, THR261H, THR289D, THR289H, TYR214D, TYR214H, TYR247D, TYR247H, TYR310H, VAL118D, VAL118H, VAL119D, VAL119H, VAL139D, VAL139H, VAL181D, VAL181H, VAL183D, VAL183H, VAL205H, VAL228D, VAL228H, VAL233D, VAL233H, VAL252D, VAL252H, VAL255D, VAL255H, VAL265D, VAL265H, VAL267D, VAL267H, VAL280D, VAL280H, VAL288D, VAL288H, VAL291D, VAL291H, VAL296D, VAL296H
• E-F: ALA20F, ALA58E, ALA58F, ALA88F, ALA90E, ARG132E, ARG154E, ARG166F, ASN158E, ASP169F, ASP64E, ASP64F, GLU125E, GLY156E, GLY61E, GLY61F, GLY63E, GLY63F, GLY83F, GLY85F, ILE57E, ILE57F, ILE80F, ILE84F, LEU128E, LEU153E, LEU50E, LEU79F, LEU82F, LEU94E, LEU95E, LYS151E, LYS172F, MET73F, PHE54E, PHE87E, PRO19F, PRO67F, PRO70F, SER168F, SER66F, SER68F, THR47E, THR56E, THR56F, THR59E, THR59F, THR69F, THR76F, TYR51E, TYR62E, TYR62F, TYR65E, TYR65F, TYR74F, VAL48E, VAL55E, VAL55F, VAL60E, VAL60F, VAL77F, VAL81F, VAL91E
• E-G: ALA58E, ALA58G, GLY61E, GLY61G, GLY63E, GLY63G, THR59E, THR59G, TYR62E, TYR62G, VAL60E, VAL60G
• E-H: ALA20E, ALA58E, ALA58H, ALA88E, ALA90H, ARG132H, ARG154H, ARG166E, ASP169E, ASP64E, ASP64H, GLU125H, GLY61E, GLY61H, GLY63E, GLY63H, GLY83E, GLY85E, ILE57E, ILE57H, ILE80E, ILE84E, LEU128H, LEU153H, LEU50H, LEU79E, LEU82E, LEU94H, LEU95H, LYS151H, LYS172E, MET73E, PHE54H, PHE87H, PRO19E, PRO67E, PRO70E, SER168E, SER66E, SER68E, THR47H, THR56E, THR56H, THR59E, THR59H, THR69E, THR76E, TRP52H, TYR51H, TYR62E, TYR62H, TYR65E, TYR65H, TYR74E, VAL48H, VAL55E, VAL55H, VAL60E, VAL60H, VAL77E, VAL81E, VAL91H
• F-G: ALA20G, ALA58F, ALA58G, ALA88G, ALA90F, ARG132F, ARG154F, ARG166G, ASP169G, ASP64F, ASP64G, GLU125F, GLY61F, GLY61G, GLY63F, GLY63G, GLY72G, GLY83G, GLY85G, ILE57F, ILE57G, ILE80G, ILE84G, LEU128F, LEU153F, LEU50F, LEU79G, LEU82G, LEU94F, LEU95F, LYS151F, LYS172G, MET73G, PHE54F, PHE87F, PRO19G, PRO67G, PRO70G, SER168G, SER49F, SER66G, SER68G, THR47F, THR56G, THR59F, THR59G, THR69G, THR76G, TRP52F, TYR51F, TYR62F, TYR62G, TYR65F, TYR65G, TYR74G, VAL48F, VAL55F, VAL55G, VAL60F, VAL60G, VAL77G, VAL81G, VAL91F
• F-H: ALA58F, ALA58H, GLY61F, GLY61H, GLY63F, GLY63H, THR59F, THR59H, TYR62F, TYR62H, VAL60F, VAL60H
• G-H: ALA20H, ALA58G, ALA58H, ALA88H, ALA90G, ARG132G, ARG154G, ARG166H, ASP169H, ASP64G, ASP64H, GLU125G, GLY156G, GLY61G, GLY61H, GLY63G, GLY63H, GLY83H, GLY85H, ILE57G, ILE57H, ILE80H, ILE84H, LEU128G, LEU153G, LEU50G, LEU79H, LEU82H, LEU94G, LEU95G, LYS151G, LYS172H, MET73H, PHE54G, PHE87G, PRO19H, PRO67H, PRO70H, SER168H, SER66H, SER68H, THR47G, THR56G, THR56H, THR59G, THR59H, THR69H, THR76H, TYR51G, TYR62G, TYR62H, TYR65G, TYR65H, VAL48G, VAL55G, VAL55H, VAL60G, VAL60H, VAL77H, VAL81H, VAL91G