1LM8

structure of a hif-1a-pvhl-elonginb-elonginc complex

• Total interactions analyzed: 6
• Total true interactions: 5
• Strongest Interaction:
  • Chains: V-H
  • Int. Res.: 59
  • Norm. En. per Res.: -5.9517
• Hub Node: C(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
B-C	-79.5931	0.6356	-329.434	-408.3914	101	15	6	12731	1	24	25
B-V	0.0	0.0	-43.4495	-43.4495	26	4	2	2288	0	5	5
C-V	-56.208	-65.7536	-256.11	-378.0717	90	17	16	11605	4	12	11
C-H	0.0	0.0	-0.1085	-0.1085	3	0	0	18	0	1	0
V-H	-63.4193	-55.3813	-232.352	-351.1526	59	8	2	7965	2	9	2

Interface residues

• B-C: ALA100C, ALA18B, ALA71B, ALA73B, ALA96C, ARG63C, ARG68B, ARG82C, ARG8B, ARG9B, ASP17B, ASP25C, ASP2B, ASP2B9, CB7.92499-28.08834, CYS74C, GLN70B, GLU102C, GLU28C, GLU89C, GLU91B, GLU92C, GLU98B, GLU98C, GLY26C, GLY33B, HIS10B, HIS27C, HIS35C, HIS68C, ILE14B, ILE22C, ILE30B, ILE30C, ILE34B, ILE65C, ILE7B, ILE90B, ILE90C, ILE95C, ILE99C, LEU101C, LEU103C, LEU104C, LEU21C, LEU35B, LEU5B, LEU70C, LEU99B, LYS104B, LYS11B, LYS20C, LYS32C, LYS72C, LYS80C, MET103B, MET17C, MET1B, MET6B, MET75C, PHE15B, PHE29C, PHE4B, PHE77C, PHE93B, PHE93C, PRO100B, PRO105B, PRO66C, PRO69B, PRO72B, PRO91C, PRO92B, PRO94C, PRO96B, PRO97B, PRO97C, SER23C, SER24C, SER64B, SER67C, SER71C, SER94B, SER95B, THR12B, THR13B, THR16B, THR74B, THR78C, THR88C, TYR18C, TYR76C, TYR79C, TYR83C, VAL102B, VAL19C, VAL31B, VAL31C, VAL69C, VAL73C, VAL81C
• B-V: ARG167V, ARG176V, ARG177V, ASN174V, ASP101B, ASP179V, CYS162V, GLN106B, GLU173V, ILE180V, LEU169V, LEU178V, LEU188V, LEU99B, LYS104B, LYS171V, MET103B, PRO100B, PRO105B, PRO172V, SER168V, TYR175V, VAL102B, VAL165V, VAL166V, VAL170V
• C-V: ALA100C, ALA106C, ALA107C, ALA96C, ARG161V, ARG167V, ARG177V, ARG182V, ARG79V, ARG82C, ARG82V, ASN108C, ASN131V, ASN150V, ASN78V, ASN85C, ASP111C, ASP121V, ASP126V, ASP179V, ASP187V, CYS112C, CYS162V, CYS74C, GLN132V, GLN164V, GLU102C, GLU160V, GLU89C, GLU92C, GLU98C, GLY104V, ILE151V, ILE180V, ILE90C, ILE95C, ILE99C, LEU101C, LEU103C, LEU104C, LEU110C, LEU128V, LEU129V, LEU153V, LEU158V, LEU163V, LEU169V, LEU178V, LEU184V, LEU188V, LEU70C, LYS159V, LYS72C, LYS80C, MET105C, MET75C, PHE109C, PHE77C, PHE93C, PRO103V, PRO154V, PRO81V, PRO91C, PRO94C, PRO97C, SER168V, SER183V, SER39C, SER80V, SER86C, SER87C, THR152V, THR157V, THR38C, THR84C, THR88C, TYR156V, TYR175V, TYR185V, TYR76C, TYR79C, TYR83C, VAL155V, VAL165V, VAL166V, VAL170V, VAL181V, VAL69C, VAL73C, VAL81C
• C-H: ARG575H, GLU89C, LEU574H
• V-H: ALA149V, ALA563H, ARG107V, ARG108V, ARG575H, ARG64V, ARG69V, ARG79V, ASN150V, ASN67V, ASN78V, ASN90V, ASP569H, ASP570H, ASP571H, ASP92V, CYS77V, GLN573H, GLN73V, GLN96V, GLU70V, GLY104V, GLY106V, HIS110V, HIS115V, ILE109V, ILE151V, ILE566H, ILE75V, LEU101V, LEU562H, LEU574H, MET561H, MET568H, PHE148V, PHE572H, PHE76V, PHE91V, PRO102V, PRO103V, PRO146V, PRO567H, PRO71V, PRO86V, PRO99V, SER111V, SER65V, SER68V, SER72V, SER80V, THR100V, THR105V, TRP117V, TRP88V, TYR112V, TYR565H, TYR98V, VAL66V, VAL74V