1LK3

engineered human interleukin-10 monomer complexed to 9d7 fab fragment

• Total interactions analyzed: 15
• Total true interactions: 9
• Strongest Interaction:
  • Chains: A-L
  • Int. Res.: 40
  • Norm. En. per Res.: -5.0329
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-L	-36.8541	-39.6052	-124.856	-201.3154	40	3	0	3782	2	11	6
A-H	-23.8329	-2.8615	-156.825	-183.5194	60	5	0	4884	0	6	6
L-H	-39.2371	-22.8447	-454.085	-516.1668	184	13	8	18488	1	12	14
L-B	0.0	-0.929	-25.7783	-26.7073	22	2	3	1394	0	4	6
H-B	0.0	0.0	-0.1107	-0.1107	8	0	0	54	0	2	4
H-I	-22.3656	-9.1463	-95.5222	-127.0341	69	4	0	4352	1	10	11
B-M	-27.0812	-40.0251	-125.934	-193.0403	39	2	0	3816	2	10	6
B-I	-27.1281	-4.8986	-158.174	-190.2007	60	5	0	4941	0	6	7
M-I	-35.3418	-15.4938	-487.913	-538.7486	192	15	8	19334	2	14	14

Interface residues

• A-L: ALA127A, ARG31L, ASN129A, ASN82A, ASN92L, ASP1L, ASP84A, GLN132A, GLN42A, GLN79A, GLN83A, GLN88L, GLN89L, GLU133A, GLU26L, GLY135A, GLY93L, HIS33L, ILE136A, LEU131A, LEU95L, LYS130A, LYS134A, LYS138A, LYS49L, MET39A, PHE128A, PHE36A, PHE37A, PRO85A, PRO94L, SER27L, SER30L, SER90L, THR29L, THR2L, THR96L, TRP91L, TYR137A, VAL28L
• A-H: ALA127A, ALA80A, ASN103H, ASN104H, ASN126A, ASN129A, ASN52H, ASN54H, ASN59H, ASN61H, ASN82A, ASP31H, ASP84A, GLN132A, GLN70A, GLN79A, GLN83A, GLU122A, GLU133A, GLU62H, GLU74A, GLU75A, GLU81A, GLY102H, GLY135A, GLY49H, GLY56H, HIS35H, ILE136A, ILE51H, LEU131A, LEU73A, LYS125A, LYS130A, LYS134A, LYS63H, LYS65H, LYS74H, LYS88A, MET77A, PHE106H, PHE128A, PHE32H, PHE71A, PRO101H, PRO78A, PRO85A, SER55H, THR58H, TRP105H, TRP47H, TYR137A, TYR33H, TYR50H, TYR57H, TYR60H, VAL100H, VAL121A, VAL124A, VAL76A
• L-H: ALA125L, ALA129L, ALA131H, ALA135H, ALA174H, ALA54L, ALA99L, ARG141L, ARG210L, ARG219H, ARG31L, ASN103H, ASN104H, ASN136L, ASN137L, ASN139H, ASN209L, ASN52L, ASN59H, ASN61H, ASN92L, ASN93H, ASP160L, ASP164L, ASP166L, ASP169L, ASP1L, CYS133L, CYS146H, CYS87L, CYS96H, GLN111H, GLN123L, GLN177H, GLN36L, GLN37L, GLN39H, GLN41L, GLN42L, GLN6H, GLN88L, GLN89L, GLU122L, GLU46H, GLU62H, GLY100L, GLY102H, GLY110H, GLY112H, GLY128L, GLY133H, GLY145H, GLY157L, GLY168H, GLY40L, GLY42H, GLY49H, GLY93L, GLY98L, GLY99H, HIS170H, HIS33L, HIS35H, ILE116L, ILE216H, ILE47L, ILE48H, ILE84L, LEU124L, LEU130H, LEU134L, LEU144H, LEU147H, LEU159L, LEU176H, LEU178L, LEU180H, LEU180L, LEU183H, LEU45H, LEU45L, LEU46L, LEU95L, LYS102L, LYS149H, LYS168L, LYS206L, LYS214H, LYS38H, LYS38L, LYS43H, LYS44L, LYS49L, LYS63H, MET135L, MET141H, MET174L, MET32L, PHE106H, PHE117L, PHE138L, PHE172H, PHE208L, PHE64H, PHE86L, PHE97L, PRO107H, PRO118L, PRO119L, PRO129H, PRO132H, PRO173H, PRO39L, PRO43L, PRO94L, SER115L, SER120L, SER126H, SER130L, SER138H, SER161L, SER167H, SER173L, SER175L, SER176L, SER178H, SER179L, SER185H, SER186H, SER207L, SER30L, SER44H, SER55L, SER90L, SER95H, THR113H, THR113L, THR121L, THR126L, THR134H, THR143H, THR163L, THR171H, THR171L, THR177L, THR182H, THR184H, THR188H, THR96L, THR97H, TRP105H, TRP109H, TRP160H, TRP194H, TRP34L, TRP36H, TRP47H, TRP91L, TYR108H, TYR128H, TYR172L, TYR181H, TYR185L, TYR33H, TYR35L, TYR48L, TYR50H, TYR60H, TYR85L, TYR94H, VAL114L, VAL127H, VAL131L, VAL132L, VAL142H, VAL148H, VAL158L, VAL162L, VAL169H, VAL175H, VAL187H, VAL212H, VAL37H, VAL3L
• L-B: ALA120B, ALA125L, ALA64B, ASP55B, GLN123L, GLN63B, GLU122L, GLU186L, GLY127L, GLY128L, GLY58B, GLY61B, LEU124L, LEU60B, LYS117B, LYS119B, LYS182L, SER118B, SER120L, THR121L, THR126L, TYR59B
• H-B: ARG219H, LYS117B, LYS119B, LYS214H, SER126H, TYR128H, TYR59B, VAL212H
• H-I: ALA10H, ALA120I, ALA124H, ALA16I, ALA204H, ALA207H, ALA24H, ALA68I, ALA9H, ARG85I, ASN3H, ASN66I, ASP73H, CYS22H, GLN111H, GLN6H, GLU121H, GLU121I, GLU62I, GLU82I, GLY15I, GLY179I, GLY79H, GLY8H, HIS205H, LEU11H, LEU180I, LEU20H, LEU5H, LEU83I, LEU86I, LYS13I, LYS19H, LYS211H, LYS23H, LYS65I, LYS67I, PHE152H, PHE152I, PHE64I, PRO14I, PRO153H, PRO155H, PRO206H, SER118I, SER119I, SER178I, SER17I, SER208H, SER209H, SER21H, SER25H, SER75H, SER77H, SER7H, SER84I, SER88I, THR113H, THR122H, THR122I, THR123H, THR123I, THR210H, THR69I, THR76H, THR78H, THR87I, TYR80H, VAL18H
• B-M: ALA127B, ARG31M, ASN129B, ASN82B, ASN92M, ASP1M, ASP84B, GLN132B, GLN42B, GLN83B, GLN88M, GLN89M, GLU133B, GLU26M, GLY135B, GLY93M, HIS33M, ILE136B, LEU131B, LEU95M, LYS130B, LYS134B, LYS138B, LYS49M, MET39B, PHE128B, PHE36B, PHE37B, PRO85B, PRO94M, SER27M, SER30M, SER90M, THR29M, THR2M, THR96M, TRP91M, TYR137B, VAL28M
• B-I: ALA127B, ALA80B, ASN103I, ASN104I, ASN126B, ASN129B, ASN52I, ASN54I, ASN59I, ASN61I, ASN82B, ASP31I, ASP84B, GLN132B, GLN70B, GLN79B, GLN83B, GLU122B, GLU133B, GLU62I, GLU74B, GLU75B, GLU81B, GLY102I, GLY135B, GLY49I, GLY56I, GLY99I, HIS35I, ILE136B, ILE51I, LEU131B, LEU73B, LYS117B, LYS125B, LYS130B, LYS134B, LYS63I, LYS65I, LYS88B, MET77B, PHE106I, PHE128B, PHE32I, PHE71B, PRO101I, PRO78B, SER55I, THR58I, TRP105I, TRP47I, TYR137B, TYR33I, TYR50I, TYR57I, TYR60I, VAL100I, VAL121B, VAL124B, VAL76B
• M-I: ALA125M, ALA129M, ALA131I, ALA174I, ALA54M, ALA83M, ALA99M, ALA9M, ARG141M, ARG210M, ARG219I, ARG31M, ASN103I, ASN104I, ASN136M, ASN137M, ASN139I, ASN209M, ASN52M, ASN59I, ASN61I, ASN92M, ASN93I, ASP160M, ASP164M, ASP166M, ASP169M, ASP1M, CYS133M, CYS146I, CYS87M, CYS96I, GLN111I, GLN123M, GLN177I, GLN37M, GLN39I, GLN41M, GLN42M, GLN6I, GLN6M, GLN88M, GLN89M, GLU122M, GLU46I, GLU62I, GLY100M, GLY102I, GLY110I, GLY112I, GLY128M, GLY133I, GLY145I, GLY150I, GLY157M, GLY168I, GLY40M, GLY42I, GLY49I, GLY93M, GLY98M, GLY99I, HIS170I, HIS33M, HIS35I, ILE116M, ILE216I, ILE47M, ILE48I, ILE84M, LEU103M, LEU124M, LEU130I, LEU134M, LEU144I, LEU147I, LEU159M, LEU176I, LEU178M, LEU180I, LEU180M, LEU183I, LEU45I, LEU45M, LEU46M, LEU95M, LYS102M, LYS149I, LYS168M, LYS206M, LYS214I, LYS215I, LYS38I, LYS43I, LYS44M, LYS49M, LYS63I, MET135M, MET141I, MET174M, MET32M, PHE106I, PHE117M, PHE138M, PHE172I, PHE208M, PHE64I, PHE86M, PHE97M, PRO107I, PRO118M, PRO119M, PRO129I, PRO132I, PRO173I, PRO39M, PRO43M, PRO7M, PRO8M, PRO94M, SER115M, SER120M, SER126I, SER130M, SER138I, SER161M, SER166I, SER167I, SER173M, SER175M, SER176M, SER178I, SER179M, SER185I, SER186I, SER207M, SER30M, SER44I, SER55M, SER90M, SER95I, THR101M, THR113I, THR113M, THR121M, THR126M, THR134I, THR143I, THR163M, THR171I, THR171M, THR177M, THR182I, THR184I, THR188I, THR2M, THR96M, THR97I, TRP105I, TRP109I, TRP160I, TRP194I, TRP34M, TRP36I, TRP47I, TRP91M, TYR108I, TYR128I, TYR172M, TYR181I, TYR185M, TYR33I, TYR35M, TYR48M, TYR50I, TYR60I, TYR85M, TYR94I, VAL114M, VAL127I, VAL131M, VAL132M, VAL142I, VAL148I, VAL158M, VAL162M, VAL169I, VAL175I, VAL187I, VAL217I, VAL37I, VAL3M