1LI1

the 1.9-a crystal structure of the noncollagenous (nc1) domain of human placenta collagen iv shows stabilization via a novel type of covalent met-lys cross-link

• Total interactions analyzed: 15
• Total true interactions: 15
• Strongest Interaction:
  • Chains: B-C
  • Int. Res.: 187
  • Norm. En. per Res.: -5.1264
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-174.1001	-43.4815	-712.446	-930.0276	194	27	17	26873	3	24	37
A-C	-177.3415	-45.9204	-697.58	-920.8419	187	28	15	25334	5	30	34
A-D	-131.6249	11.6073	-303.594	-423.6115	103	20	0	9985	4	22	23
A-E	0.0	12.5429	-98.0899	-85.547	62	17	2	4129	0	0	7
A-F	0.0	0.0	-0.3631	-0.3631	11	0	0	82	0	3	4
B-C	-218.2049	-43.0617	-697.379	-958.6456	187	27	19	26073	4	26	29
B-D	-8.9507	0.0	-106.87	-115.8207	64	12	2	4139	0	0	7
B-E	-8.7547	0.0	-9.1766	-17.9314	11	0	0	421	0	2	3
B-F	-119.1966	47.5903	-336.538	-408.1443	107	18	1	10821	5	27	31
C-D	0.0	0.0	-0.3607	-0.3607	11	0	0	82	0	3	4
C-E	-94.7572	48.3541	-325.717	-372.1201	106	15	1	10463	5	27	31
C-F	-7.4035	48.4308	-130.864	-89.8368	60	9	1	4240	0	12	15
D-E	-207.7742	-46.7419	-715.082	-969.5981	197	32	17	26765	2	24	36
D-F	-186.6074	-34.797	-720.079	-941.4835	190	39	16	26213	5	30	34
E-F	-210.5701	-45.3902	-682.363	-938.3233	187	31	19	26156	4	25	27

Interface residues

• A-B: ALA113A, ALA115A, ALA115B, ALA119B, ALA149B, ALA151B, ALA157B, ALA159B, ALA171B, ALA186B, ALA188B, ALA194B, ALA212B, ALA42A, ALA42B, ALA50A, ALA74A, ARG102A, ARG107A, ARG169B, ARG179A, ARG198B, ARG216B, ARG221B, ARG227B, ARG228B, ARG41A, ARG41B, ARG55A, ARG76A, ASN100A, ASN183B, ASN187B, ASN39A, ASN66A, ASN68A, ASN69A, ASN72A, ASN77A, ASP3A, ASP3B, ASP46A, ASP46B, ASP78A, CYS111A, CYS130B, CYS176A, CYS182A, CYS222B, CYS225B, CYS53A, CYS65A, CYS71A, GLN123B, GLN126B, GLN156B, GLN223B, GLN37A, GLN45A, GLU112A, GLU152A, GLU152B, GLU175B, GLU197B, GLU200B, GLU214B, GLU40A, GLU99A, GLY133B, GLY150B, GLY153B, GLY155B, GLY178A, GLY180A, GLY213B, GLY30A, GLY38A, GLY44A, GLY44B, GLY48A, GLY51A, GLY5A, GLY98A, HIS121B, HIS146B, HIS177A, HIS218B, HIS43A, HIS43B, HIS4A, HIS4B, ILE101A, ILE105A, ILE125B, ILE127B, ILE15A, ILE174B, ILE196B, ILE26A, ILE67A, ILE96A, LEU158B, LEU193B, LEU210B, LEU215B, LEU27A, LEU33A, LEU54A, LEU63A, LEU7A, LYS203B, LYS204B, LYS211B, LYS25A, LYS56A, MET116A, MET116B, MET118B, MET145B, MET201B, MET226B, MET60A, MET89B, MET93B, PHE104A, PHE143B, PHE168B, PHE173B, PHE191B, PHE202B, PHE57A, PHE62A, PHE64A, PHE6A, PHE6B, PHE73A, PRO103A, PRO114A, PRO114B, PRO128B, PRO129B, PRO131B, PRO172B, PRO205B, PRO207B, PRO61A, SER122B, SER132B, SER142B, SER148B, SER154B, SER160B, SER163B, SER170B, SER190B, SER199B, SER208B, SER220B, SER52A, SER58A, SER75A, SER80A, THR124B, THR147B, THR181A, THR195B, THR206B, THR209B, THR217B, THR229B, THR49A, THR59A, THR97A, THR9A, TRP134B, TRP192B, TRP82A, TYR184B, TYR185B, TYR189B, TYR28A, TYR31A, TYR35A, TYR35B, TYR79A, VAL110A, VAL117A, VAL117B, VAL120B, VAL144B, VAL219B, VAL2A, VAL36A, VAL70A
• A-C: ALA113C, ALA115A, ALA115C, ALA117C, ALA119A, ALA149A, ALA151A, ALA157A, ALA159A, ALA171A, ALA186A, ALA188A, ALA194A, ALA212A, ALA42A, ALA42C, ALA50C, ALA55C, ALA74C, ALA97C, ARG107C, ARG169A, ARG179C, ARG198A, ARG216A, ARG227A, ARG228A, ARG41A, ARG56C, ARG76C, ASN177C, ASN183A, ASN187A, ASN25C, ASN44C, ASN66C, ASN77C, ASP46A, ASP46C, ASP69C, ASP78C, ASP99C, CYS111C, CYS130A, CYS176C, CYS182C, CYS225A, CYS53C, CYS65C, CYS71C, GLN123A, GLN126A, GLN156A, GLN37A, GLN39C, GLN45C, GLU100C, GLU112C, GLU152A, GLU152C, GLU17C, GLU197A, GLU200A, GLU214A, GLU37C, GLU40A, GLU40C, GLU98C, GLY133A, GLY150A, GLY153A, GLY155A, GLY177C, GLY178C, GLY180C, GLY213A, GLY30C, GLY38C, GLY44A, GLY51C, GLY5C, GLY68C, HIS121A, HIS146A, HIS218A, HIS43A, HIS43C, HIS4A, ILE101C, ILE105C, ILE116C, ILE125A, ILE174A, ILE196A, LEU158A, LEU193A, LEU210A, LEU215A, LEU229C, LEU27C, LEU33C, LEU49C, LEU54C, LEU63C, LEU7C, LYS102C, LYS203A, LYS204A, LYS211A, LYS26C, LYS41C, LYS79C, MET116A, MET118A, MET145A, MET201A, MET226A, MET60C, MET89A, MET93A, PHE143A, PHE168A, PHE173A, PHE191A, PHE202A, PHE36C, PHE57C, PHE62C, PHE6A, PRO103C, PRO114A, PRO114C, PRO131A, PRO172A, PRO205A, PRO207A, PRO61C, PRO67C, SER122A, SER132A, SER142A, SER148A, SER154A, SER160A, SER163A, SER170A, SER190A, SER199A, SER208A, SER220A, SER29C, SER52C, SER58C, SER75C, SER80C, THR124A, THR147A, THR181C, THR195A, THR206A, THR209A, THR217A, THR229A, THR59C, TRP134A, TRP192A, TRP28C, TRP82C, TYR104C, TYR184A, TYR185A, TYR189A, TYR31C, TYR35A, TYR35C, TYR64C, TYR6C, TYR72C, TYR73C, VAL110C, VAL117A, VAL120A, VAL144A, VAL219A, VAL70C, VAL96C, VAL9C
• A-D: ALA149A, ALA149D, ALA151A, ALA151D, ALA186A, ALA186D, ALA188A, ALA188D, ALA42A, ALA42D, ALA74A, ALA74D, ALA94A, ALA94D, ARG179A, ARG179D, ARG41A, ARG41D, ARG76A, ARG76D, ASN183A, ASN183D, ASN187A, ASN187D, ASN39A, ASN39D, ASN66A, ASN66D, ASN68A, ASN68D, ASN72A, ASN72D, ASN77A, ASN77D, ASP78A, ASP78D, CYS176A, CYS176D, CYS182A, CYS182D, CYS71A, GLN37A, GLN37D, GLU152A, GLU152D, GLU175A, GLU175D, GLU40A, GLU40D, GLY150A, GLY150D, GLY178A, GLY178D, GLY180A, GLY180D, GLY38A, GLY38D, HIS177A, HIS177D, ILE67A, ILE67D, MET60A, MET60D, MET89A, MET89D, MET93A, MET93D, PHE173A, PHE173D, PHE62A, PHE62D, PHE64A, PHE64D, PHE73A, PHE73D, PRO95A, PRO95D, SER148A, SER148D, SER75A, SER75D, SER80A, SER80D, SER92A, SER92D, THR147A, THR147D, THR181A, THR181D, TYR184A, TYR184D, TYR185A, TYR185D, TYR189A, TYR189D, TYR35A, TYR35D, TYR79A, TYR79D, TYR81A, TYR81D, VAL70A, VAL70D
• A-E: ALA149A, ALA149E, ALA151A, ALA151E, ALA186A, ALA186E, ALA188A, ALA188E, ALA212A, ALA94A, ALA94E, ARG179A, ARG179E, ASN183A, ASN183E, ASN187A, ASN187E, GLU152A, GLU152E, GLU214A, GLY150A, GLY150E, LEU210A, LEU210E, LEU215A, LYS204A, LYS204E, LYS211A, LYS211E, MET89A, MET91A, MET91E, MET93A, MET93E, PHE191A, PHE191E, PRO205A, PRO207A, PRO207E, PRO90A, PRO90E, PRO95A, PRO95E, SER148A, SER148E, SER208A, SER208E, SER92A, SER92E, THR147A, THR147E, THR181A, THR181E, THR206A, THR209A, THR209E, THR97A, THR97E, TYR185A, TYR185E, TYR189A, TYR189E
• A-F: ARG76A, ASN66A, ASN66F, ASN68A, GLY68F, ILE67A, LYS204A, PRO67F, SER204F, TYR72F, VAL70F
• B-C: ALA113B, ALA115B, ALA115C, ALA117C, ALA119C, ALA132C, ALA148C, ALA149C, ALA170C, ALA186C, ALA207C, ALA212C, ALA42B, ALA42C, ALA50B, ALA74B, ARG102B, ARG107B, ARG169C, ARG179B, ARG216C, ARG41B, ARG55B, ARG76B, ASN100B, ASN187C, ASN228C, ASN39B, ASN44C, ASN66B, ASN68B, ASN69B, ASN72B, ASP124C, ASP151C, ASP208C, ASP3B, ASP46B, ASP46C, ASP78B, CYS111B, CYS130C, CYS176B, CYS182B, CYS225C, CYS53B, CYS65B, CYS71B, GLN123C, GLN156C, GLN199C, GLN202C, GLN37B, GLN45B, GLU112B, GLU152B, GLU152C, GLU198C, GLU37C, GLU40B, GLU40C, GLU99B, GLY133C, GLY150C, GLY153C, GLY154C, GLY155C, GLY178B, GLY180B, GLY203C, GLY213C, GLY30B, GLY38B, GLY44B, GLY48B, GLY51B, GLY5B, GLY5C, GLY98B, HIS121C, HIS129C, HIS146C, HIS177B, HIS183C, HIS218C, HIS29B, HIS43B, HIS43C, HIS4B, ILE101B, ILE105B, ILE116C, ILE118C, ILE196C, ILE215C, ILE219C, ILE26B, ILE67B, ILE96B, LEU144C, LEU158C, LEU193C, LEU210C, LEU214C, LEU229C, LEU27B, LEU33B, LEU54B, LEU63B, LEU7B, LEU89C, LYS188C, LYS211C, LYS227C, LYS25B, LYS41C, LYS56B, MET116B, MET145C, MET226C, MET60B, MET93C, PHE104B, PHE143C, PHE168C, PHE173C, PHE191C, PHE201C, PHE57B, PHE62B, PHE64B, PHE6B, PHE73B, PRO103B, PRO114B, PRO114C, PRO128C, PRO131C, PRO172C, PRO197C, PRO205C, PRO61B, PRO90C, SER122C, SER126C, SER142C, SER157C, SER160C, SER163C, SER190C, SER200C, SER204C, SER206C, SER220C, SER52B, SER58B, SER75B, SER80B, THR147C, THR171C, THR181B, THR194C, THR195C, THR209C, THR217C, THR49B, THR59B, THR97B, THR9B, TRP134C, TRP192C, TRP82B, TYR184C, TYR185C, TYR189C, TYR28B, TYR31B, TYR35B, TYR35C, TYR6C, TYR79B, VAL110B, VAL120C, VAL125C, VAL159C, VAL36B, VAL70B
• B-D: ALA149B, ALA149D, ALA151B, ALA151D, ALA186B, ALA186D, ALA188B, ALA188D, ALA212D, ALA94B, ALA94D, ARG179B, ARG179D, ASN183B, ASN183D, ASN187B, ASN187D, GLU152B, GLU152D, GLU175B, GLU214D, GLY150B, GLY150D, LEU210B, LEU210D, LEU215D, LYS204B, LYS204D, LYS211B, LYS211D, MET89D, MET91B, MET91D, MET93B, MET93D, PHE191B, PHE191D, PRO205D, PRO207B, PRO207D, PRO90B, PRO90D, PRO95B, PRO95D, SER148B, SER148D, SER208B, SER208D, SER92B, SER92D, THR147B, THR147D, THR181B, THR181D, THR206D, THR209B, THR209D, THR97B, THR97D, TYR184D, TYR185B, TYR185D, TYR189B, TYR189D
• B-E: ARG76E, ASN39B, ASN39E, ASN66B, ASN66E, ASN68B, ASN68E, ILE67B, ILE67E, LYS204B, LYS204E
• B-F: ALA148F, ALA149B, ALA149F, ALA151B, ALA186B, ALA186F, ALA188B, ALA42B, ALA42F, ALA74B, ALA74F, ALA94B, ARG179B, ARG179F, ARG41B, ARG76B, ARG76F, ASN177F, ASN183B, ASN187B, ASN187F, ASN39B, ASN66B, ASN66F, ASN68B, ASN69B, ASN72B, ASN77B, ASN77F, ASP151F, ASP69F, ASP78B, ASP78F, CYS176B, CYS176F, CYS182B, CYS182F, CYS65B, CYS65F, CYS71B, CYS71F, GLN37B, GLN39F, GLU152B, GLU152F, GLU175B, GLU175F, GLU37F, GLU40B, GLU40F, GLY150B, GLY150F, GLY177F, GLY178B, GLY178F, GLY180B, GLY180F, GLY38B, GLY38F, GLY68F, HIS177B, HIS183F, ILE67B, LEU89F, LYS188F, LYS41F, LYS79F, MET60B, MET60F, MET89B, MET93B, MET93F, MET94F, PHE173B, PHE173F, PHE64B, PHE73B, PRO67F, PRO90B, PRO95B, PRO95F, SER148B, SER75B, SER75F, SER80B, SER80F, SER92B, THR147B, THR147F, THR181B, THR181F, THR59B, TYR184B, TYR184F, TYR185B, TYR185F, TYR189B, TYR189F, TYR35F, TYR64F, TYR72F, TYR73F, TYR79B, TYR81B, TYR81F, VAL70B, VAL70F
• C-D: ARG76D, ASN66C, ASN66D, ASN68D, GLY68C, ILE67D, LYS204D, PRO67C, SER204C, TYR72C, VAL70C
• C-E: ALA148C, ALA149C, ALA149E, ALA151E, ALA186C, ALA186E, ALA188E, ALA42C, ALA42E, ALA74C, ALA74E, ALA94E, ARG179C, ARG179E, ARG41E, ARG76C, ARG76E, ASN177C, ASN183E, ASN187C, ASN187E, ASN39E, ASN66C, ASN66E, ASN68E, ASN69E, ASN72E, ASN77C, ASN77E, ASP151C, ASP69C, ASP78C, ASP78E, CYS176C, CYS176E, CYS182C, CYS182E, CYS65C, CYS65E, CYS71C, CYS71E, GLN37E, GLN39C, GLU152C, GLU152E, GLU175C, GLU175E, GLU37C, GLU40C, GLU40E, GLY150C, GLY150E, GLY177C, GLY178C, GLY178E, GLY180C, GLY180E, GLY38C, GLY38E, GLY68C, HIS177E, HIS183C, ILE67E, LEU89C, LYS188C, LYS41C, LYS79C, MET60C, MET60E, MET93C, MET93E, MET94C, PHE173C, PHE173E, PHE64E, PHE73E, PRO67C, PRO95C, PRO95E, SER148E, SER75C, SER75E, SER80C, SER80E, SER92E, THR147C, THR147E, THR181C, THR181E, THR59E, TYR184C, TYR184E, TYR185C, TYR185E, TYR189C, TYR189E, TYR35C, TYR35E, TYR64C, TYR72C, TYR73C, TYR79E, TYR81C, TYR81E, VAL70C, VAL70E
• C-F: ALA148C, ALA148F, ALA149C, ALA149F, ALA186C, ALA186F, ALA207C, ALA207F, ARG179C, ARG179F, ASN177C, ASN177F, ASN187C, ASN187F, ASP151C, ASP151F, ASP208C, ASP208F, GLU152C, GLU152F, GLU175F, GLU40C, GLU40F, GLY150C, GLY150F, HIS183C, HIS183F, LEU210C, LEU210F, LYS188C, LYS188F, LYS211C, LYS211F, MET93C, MET93F, MET94C, MET94F, PHE191C, PHE191F, PRO205C, PRO205F, PRO90F, PRO95C, PRO95F, SER204C, SER204F, SER206C, SER206F, THR147C, THR147F, THR181C, THR181F, THR209C, THR209F, TYR184C, TYR184F, TYR185C, TYR185F, TYR189C, TYR189F
• D-E: ALA113D, ALA115D, ALA115E, ALA119E, ALA149E, ALA151E, ALA157E, ALA159E, ALA171E, ALA186E, ALA188E, ALA194E, ALA212E, ALA42D, ALA42E, ALA50D, ALA74D, ARG102D, ARG107D, ARG169E, ARG179D, ARG198E, ARG216E, ARG221E, ARG227E, ARG228E, ARG41D, ARG41E, ARG55D, ARG76D, ASN100D, ASN183E, ASN187E, ASN39D, ASN66D, ASN68D, ASN69D, ASN72D, ASN77D, ASP3D, ASP3E, ASP46D, ASP46E, ASP78D, CYS111D, CYS130E, CYS176D, CYS182D, CYS222E, CYS225E, CYS53D, CYS65D, CYS71D, GLN123E, GLN126E, GLN156E, GLN223E, GLN37D, GLN45D, GLU112D, GLU152D, GLU152E, GLU175E, GLU197E, GLU200E, GLU214E, GLU40D, GLU99D, GLY133E, GLY150E, GLY153E, GLY155E, GLY178D, GLY180D, GLY213E, GLY30D, GLY38D, GLY44D, GLY44E, GLY48D, GLY51D, GLY5D, GLY5E, GLY98D, HIS121E, HIS146E, HIS177D, HIS218E, HIS43D, HIS43E, HIS4D, HIS4E, ILE101D, ILE105D, ILE125E, ILE127E, ILE15D, ILE174E, ILE196E, ILE26D, ILE67D, ILE96D, LEU158E, LEU193E, LEU210E, LEU215E, LEU27D, LEU33D, LEU54D, LEU63D, LEU7D, LYS203E, LYS204E, LYS211E, LYS25D, LYS56D, MET116D, MET116E, MET118E, MET145E, MET201E, MET226E, MET60D, MET89E, MET93E, PHE104D, PHE143E, PHE168E, PHE173E, PHE191E, PHE202E, PHE57D, PHE62D, PHE64D, PHE6D, PHE6E, PHE73D, PRO103D, PRO114D, PRO114E, PRO128E, PRO129E, PRO131E, PRO172E, PRO205E, PRO207E, PRO61D, SER106D, SER122E, SER132E, SER142E, SER148E, SER154E, SER160E, SER163E, SER170E, SER190E, SER199E, SER208E, SER220E, SER52D, SER58D, SER75D, SER80D, SER84E, THR124E, THR147E, THR181D, THR195E, THR206E, THR209E, THR217E, THR229E, THR49D, THR59D, THR97D, THR9D, TRP134E, TRP192E, TRP82D, TYR184E, TYR185E, TYR189E, TYR28D, TYR31D, TYR35D, TYR35E, TYR79D, VAL110D, VAL117D, VAL117E, VAL120E, VAL144E, VAL219E, VAL2D, VAL36D, VAL70D
• D-F: ALA113D, ALA113F, ALA115D, ALA115F, ALA117F, ALA119D, ALA149D, ALA151D, ALA157D, ALA159D, ALA171D, ALA186D, ALA188D, ALA194D, ALA212D, ALA42D, ALA42F, ALA50F, ALA55F, ALA74F, ALA97F, ARG107F, ARG169D, ARG179F, ARG198D, ARG216D, ARG227D, ARG228D, ARG41D, ARG56F, ARG76F, ASN177F, ASN183D, ASN187D, ASN25F, ASN44F, ASN66F, ASN77F, ASP3D, ASP46D, ASP46F, ASP69F, ASP78F, ASP99F, CYS111F, CYS130D, CYS176F, CYS182F, CYS225D, CYS53F, CYS65F, CYS71F, GLN123D, GLN126D, GLN156D, GLN37D, GLN39F, GLN45F, GLU100F, GLU112F, GLU152D, GLU152F, GLU197D, GLU200D, GLU214D, GLU37F, GLU40D, GLU40F, GLU98F, GLY133D, GLY150D, GLY153D, GLY155D, GLY177F, GLY178F, GLY180F, GLY213D, GLY30F, GLY38F, GLY44D, GLY51F, GLY5D, GLY5F, GLY68F, HIS121D, HIS146D, HIS218D, HIS43D, HIS43F, HIS4D, ILE101F, ILE105F, ILE116F, ILE125D, ILE174D, ILE196D, ILE4F, LEU158D, LEU193D, LEU210D, LEU215D, LEU229F, LEU27F, LEU33F, LEU49F, LEU54F, LEU63F, LEU7F, LYS102F, LYS203D, LYS204D, LYS211D, LYS26F, LYS41F, LYS79F, MET116D, MET118D, MET145D, MET201D, MET226D, MET60F, MET89D, MET93D, PHE143D, PHE168D, PHE173D, PHE191D, PHE202D, PHE36F, PHE57F, PHE62F, PHE6D, PRO103F, PRO114D, PRO114F, PRO131D, PRO172D, PRO205D, PRO207D, PRO61F, PRO67F, SER122D, SER132D, SER142D, SER148D, SER154D, SER160D, SER163D, SER170D, SER190D, SER199D, SER208D, SER220D, SER52F, SER58F, SER75F, SER80F, THR124D, THR147D, THR181F, THR195D, THR206D, THR209D, THR217D, THR229D, THR59F, TRP134D, TRP192D, TRP28F, TRP82F, TYR104F, TYR184D, TYR185D, TYR189D, TYR31F, TYR35D, TYR35F, TYR64F, TYR6F, TYR72F, TYR73F, VAL110F, VAL117D, VAL120D, VAL144D, VAL219D, VAL2D, VAL70F, VAL96F, VAL9F
• E-F: ALA113E, ALA113F, ALA115F, ALA117F, ALA119F, ALA132F, ALA148F, ALA149F, ALA170F, ALA186F, ALA207F, ALA212F, ALA42E, ALA42F, ALA50E, ALA74E, ARG102E, ARG107E, ARG169F, ARG179E, ARG216F, ARG41E, ARG55E, ARG76E, ASN100E, ASN187F, ASN228F, ASN39E, ASN44F, ASN66E, ASN68E, ASN69E, ASN72E, ASP124F, ASP151F, ASP208F, ASP3E, ASP46E, ASP46F, ASP78E, CYS111E, CYS130F, CYS176E, CYS182E, CYS225F, CYS53E, CYS65E, CYS71E, GLN123F, GLN156F, GLN199F, GLN202F, GLN37E, GLN45E, GLU112E, GLU152E, GLU152F, GLU198F, GLU37F, GLU40E, GLU40F, GLU99E, GLY133F, GLY150F, GLY153F, GLY154F, GLY155F, GLY178E, GLY180E, GLY203F, GLY213F, GLY30E, GLY38E, GLY44E, GLY48E, GLY51E, GLY5E, GLY5F, GLY98E, HIS121F, HIS129F, HIS146F, HIS177E, HIS183F, HIS218F, HIS29E, HIS43E, HIS43F, HIS4E, ILE101E, ILE105E, ILE116F, ILE118F, ILE196F, ILE215F, ILE219F, ILE26E, ILE4F, ILE67E, ILE96E, LEU144F, LEU158F, LEU193F, LEU210F, LEU214F, LEU229F, LEU27E, LEU33E, LEU54E, LEU63E, LEU7E, LEU89F, LYS188F, LYS211F, LYS227F, LYS25E, LYS41F, LYS56E, MET116E, MET145F, MET60E, MET93F, PHE104E, PHE143F, PHE168F, PHE173F, PHE191F, PHE201F, PHE57E, PHE62E, PHE64E, PHE6E, PHE73E, PRO103E, PRO114E, PRO114F, PRO128F, PRO131F, PRO172F, PRO197F, PRO205F, PRO61E, PRO90F, SER122F, SER126F, SER142F, SER157F, SER160F, SER163F, SER190F, SER200F, SER204F, SER206F, SER220F, SER52E, SER58E, SER75E, SER80E, THR147F, THR171F, THR181E, THR194F, THR195F, THR209F, THR217F, THR49E, THR59E, THR97E, THR9E, TRP134F, TRP192F, TRP82E, TYR184F, TYR185F, TYR189F, TYR28E, TYR31E, TYR35E, TYR35F, TYR6F, TYR79E, VAL110E, VAL120F, VAL125F, VAL159F, VAL36E, VAL70E