1L6W

fructose-6-phosphate aldolase

• Total interactions analyzed: 45
• Total true interactions: 25
• Strongest Interaction:
  • Chains: F-J
  • Int. Res.: 147
  • Norm. En. per Res.: -3.2064
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-30.1437	-40.0412	-396.862	-467.047	147	13	26	17402	4	15	17
A-E	-29.1822	-39.8109	-398.879	-467.8721	146	21	26	18142	4	14	15
A-F	-7.3346	-9.9563	-151.934	-169.2249	66	5	0	6357	0	14	15
A-G	0.0	0.0	-6.3399	-6.3399	28	0	0	596	0	0	2
A-J	0.0	0.0	-19.0716	-19.0716	14	0	1	809	0	2	1
B-C	-23.04	4.6799	-373.982	-392.3421	146	9	25	16872	3	15	15
B-F	0.0	0.0	-19.0954	-19.0954	14	0	1	827	0	2	1
B-G	-8.1752	-10.3218	-160.488	-178.9849	66	12	0	6651	0	14	15
B-H	0.0	0.0	-6.0779	-6.0779	28	0	0	586	0	0	2
C-D	-28.46	-40.8247	-387.107	-456.3917	144	11	23	17239	4	15	17
C-G	0.0	0.0	-16.6479	-16.6479	14	0	1	774	0	2	1
C-H	-7.4251	-10.1253	-159.329	-176.8794	66	11	0	6586	0	14	15
C-I	0.0	0.0	-6.8075	-6.8075	28	0	0	630	0	0	2
D-E	-42.8087	-35.3891	-372.076	-450.2738	141	6	23	16510	3	15	15
D-H	0.0	0.0	-18.4347	-18.4347	14	0	1	791	0	2	1
D-I	-7.9567	-10.2007	-157.749	-175.9065	69	10	0	6531	0	14	15
D-J	0.0	0.0	-6.3059	-6.3059	28	0	0	587	0	0	2
E-F	0.0	0.0	-5.7573	-5.7573	27	0	0	556	0	0	2
E-I	0.0	0.0	-16.0262	-16.0262	15	0	1	778	0	2	1
E-J	-6.8732	-10.3438	-155.007	-172.224	68	7	0	6465	0	14	15
F-G	-25.1818	-30.2313	-373.842	-429.2551	142	8	23	16525	3	15	15
F-J	-37.4459	-33.2535	-400.643	-471.3424	147	14	25	17591	4	15	17
G-H	-25.8788	-31.5217	-381.446	-438.8466	144	10	25	17231	3	15	16
H-I	-27.2167	-38.5954	-387.398	-453.2101	146	13	23	17294	4	15	17
I-J	-28.9429	-30.4631	-376.235	-435.641	144	7	24	16916	3	15	13

Interface residues

• A-B: ALA110A, ALA114A, ALA115A, ALA121A, ALA123A, ALA157A, ALA15B, ALA173B, ALA179B, ALA191B, ALA199B, ALA202B, ALA203B, ALA205B, ALA214B, ALA23B, ALA33A, ALA34A, ALA58A, ALA62A, ALA65A, ALA72A, ALA90A, ALA94A, ALA95A, ARG134A, ARG171B, ARG18B, ARG217B, ARG76A, ASN28A, ASN70A, ASP148A, ASP175B, ASP201B, ASP210B, ASP40A, ASP71A, CYS176B, CYS181B, GLN116A, GLN138A, GLN144A, GLN151A, GLN192B, GLN193B, GLN209B, GLN212B, GLN59A, GLU182B, GLU208B, GLU2B, GLU66A, GLU91A, GLY113A, GLY117A, GLY124A, GLY180B, GLY213B, GLY35A, GLY67A, GLY92A, HIS150A, HIS150B, HIS156A, ILE135A, ILE184B, ILE195B, ILE19B, ILE220B, ILE31A, ILE32A, ILE78A, ILE82A, ILE96A, LEU118A, LEU119A, LEU122A, LEU149A, LEU152A, LEU153A, LEU16B, LEU174B, LEU177B, LEU178B, LEU186B, LEU22B, LEU39A, LEU3B, LEU43A, LEU73A, LEU75A, LEU93A, LYS100A, LYS154B, LYS206B, LYS36A, LYS37A, LYS74A, LYS85A, LYS97A, MET155A, MET194B, MET1B, MET61A, MET68A, MET98A, PHE207B, PHE20B, PHE215B, PRO158A, PRO170B, PRO198B, PRO21B, PRO29A, PRO38A, PRO87A, SER120A, SER166A, SER17B, SER183B, SER196B, SER219B, SER30A, THR109A, THR145A, THR147A, THR218B, THR27A, THR63A, THR64A, THR89A, TRP211B, TYR112A, TYR131A, TYR197B, VAL111A, VAL162B, VAL190B, VAL200B, VAL204B, VAL41A, VAL42A, VAL60A, VAL84A, VAL86A, VAL88A
• A-E: ALA110E, ALA114E, ALA115E, ALA121E, ALA123E, ALA157E, ALA15A, ALA173A, ALA179A, ALA191A, ALA199A, ALA202A, ALA203A, ALA205A, ALA214A, ALA33E, ALA34E, ALA58E, ALA62E, ALA65E, ALA72E, ALA90E, ALA94E, ALA95E, ARG134E, ARG171A, ARG18A, ARG217A, ARG76E, ASN28E, ASN70E, ASP148E, ASP175A, ASP201A, ASP210A, ASP40E, ASP71E, CYS176A, CYS181A, GLN116E, GLN138E, GLN144E, GLN151E, GLN192A, GLN193A, GLN209A, GLN212A, GLN59E, GLU182A, GLU208A, GLU2A, GLU66E, GLU91E, GLY113E, GLY117E, GLY124E, GLY180A, GLY213A, GLY35E, GLY67E, GLY92E, HIS150A, HIS150E, HIS156E, ILE135E, ILE184A, ILE195A, ILE19A, ILE220A, ILE31E, ILE32E, ILE78E, ILE82E, ILE96E, LEU118E, LEU119E, LEU122E, LEU149E, LEU152E, LEU153E, LEU16A, LEU174A, LEU177A, LEU178A, LEU186A, LEU22A, LEU39E, LEU3A, LEU43E, LEU73E, LEU75E, LEU93E, LYS154A, LYS206A, LYS36E, LYS37E, LYS74E, LYS85E, LYS97E, MET155E, MET194A, MET1A, MET61E, MET68E, MET98E, PHE207A, PHE20A, PHE215A, PRO158E, PRO170A, PRO198A, PRO21A, PRO29E, PRO38E, PRO87E, SER120E, SER166E, SER17A, SER183A, SER196A, SER219A, SER30E, SER77E, THR109E, THR145E, THR147E, THR218A, THR27E, THR63E, THR64E, THR89E, TRP211A, TYR112E, TYR131E, TYR197A, VAL111E, VAL190A, VAL200A, VAL204A, VAL41E, VAL42E, VAL60E, VAL69E, VAL84E, VAL86E, VAL88E
• A-F: ALA137A, ALA137F, ALA173F, ALA199A, ALA199F, ARG134A, ARG134F, ARG171A, ARG171F, ASN133A, ASN133F, ASP136A, ASP136F, ASP175A, ASP175F, ASP189A, ASP189F, GLN138A, GLN138F, GLN144A, GLN144F, GLN172A, GLN172F, GLN193A, GLN193F, GLY139A, GLY139F, GLY140A, GLY140F, GLY142A, GLY142F, ILE135A, ILE135F, ILE143A, ILE143F, ILE195A, ILE195F, LEU174A, LEU174F, LYS168A, LYS168F, MET194A, MET194F, PHE167A, PHE167F, PRO170A, PRO170F, PRO198A, PRO198F, SER141A, SER141F, SER196A, SER196F, THR145A, THR169A, THR169F, TYR112A, TYR112F, TYR197A, TYR197F, VAL132A, VAL132F, VAL190A, VAL190F, VAL200A, VAL200F
• A-G: ALA114A, ALA114G, ALA115A, ALA115G, ALA137A, ALA137G, ASP148A, ASP148G, GLN116A, GLN116G, GLN138A, GLN138G, GLN144A, GLN144G, GLY113A, GLY113G, GLY139A, GLY139G, GLY140A, GLY140G, ILE135A, ILE135G, SER141A, SER141G, THR145A, THR145G, TYR112A, TYR112G
• A-J: ALA199A, ALA199J, ALA202A, ALA202J, ALA203A, ALA203J, ASP201A, ASP201J, PRO198A, PRO198J, TYR197A, TYR197J, VAL200A, VAL200J
• B-C: ALA110B, ALA114B, ALA115B, ALA121B, ALA123B, ALA157B, ALA15C, ALA173C, ALA179C, ALA191C, ALA199C, ALA202C, ALA203C, ALA205C, ALA214C, ALA33B, ALA34B, ALA58B, ALA62B, ALA65B, ALA72B, ALA90B, ALA94B, ALA95B, ARG134B, ARG171C, ARG18C, ARG217C, ARG76B, ASN28B, ASN70B, ASP148B, ASP175C, ASP201C, ASP210C, ASP40B, ASP71B, CYS176C, CYS181C, GLN116B, GLN138B, GLN144B, GLN151B, GLN192C, GLN193C, GLN209C, GLN212C, GLN59B, GLU182C, GLU208C, GLU2C, GLU66B, GLU91B, GLY113B, GLY117B, GLY124B, GLY180C, GLY213C, GLY35B, GLY67B, GLY92B, HIS150B, HIS150C, HIS156B, ILE135B, ILE184C, ILE195C, ILE19C, ILE220C, ILE31B, ILE32B, ILE78B, ILE82B, ILE96B, LEU118B, LEU119B, LEU122B, LEU149B, LEU152B, LEU153B, LEU16C, LEU174C, LEU177C, LEU178C, LEU186C, LEU22C, LEU39B, LEU3C, LEU43B, LEU73B, LEU75B, LEU93B, LYS154C, LYS206C, LYS36B, LYS37B, LYS74B, LYS85B, LYS97B, MET155B, MET194C, MET1C, MET61B, MET68B, MET98B, PHE207C, PHE20C, PHE215C, PRO158B, PRO170C, PRO198C, PRO21C, PRO29B, PRO38B, PRO87B, SER120B, SER166B, SER17C, SER183C, SER196C, SER219C, SER30B, SER8B, THR109B, THR145B, THR147B, THR218C, THR27B, THR63B, THR64B, THR89B, TRP211C, TYR112B, TYR131B, TYR197C, VAL111B, VAL190C, VAL200C, VAL204C, VAL41B, VAL42B, VAL60B, VAL69B, VAL84B, VAL86B, VAL88B
• B-F: ALA199B, ALA199F, ALA202B, ALA202F, ALA203B, ALA203F, ASP201B, ASP201F, PRO198B, PRO198F, TYR197B, TYR197F, VAL200B, VAL200F
• B-G: ALA137B, ALA137G, ALA173B, ALA173G, ALA199B, ALA199G, ARG134B, ARG134G, ARG171B, ARG171G, ASN133B, ASN133G, ASP136B, ASP136G, ASP175B, ASP175G, ASP189B, ASP189G, GLN138B, GLN138G, GLN144B, GLN144G, GLN172B, GLN172G, GLN193B, GLN193G, GLY139B, GLY139G, GLY140B, GLY140G, GLY142B, GLY142G, ILE135B, ILE135G, ILE143B, ILE143G, ILE195B, ILE195G, LEU174B, LEU174G, LYS168B, LYS168G, MET194B, MET194G, PHE167B, PHE167G, PRO170B, PRO170G, PRO198B, PRO198G, SER141B, SER141G, SER196B, SER196G, THR169B, THR169G, TYR112B, TYR112G, TYR197B, TYR197G, VAL132B, VAL132G, VAL190B, VAL190G, VAL200B, VAL200G
• B-H: ALA114B, ALA114H, ALA115B, ALA115H, ALA137B, ALA137H, ASP148B, ASP148H, GLN116B, GLN116H, GLN138B, GLN138H, GLN144B, GLN144H, GLY113B, GLY113H, GLY139B, GLY139H, GLY140B, GLY140H, ILE135B, ILE135H, SER141B, SER141H, THR145B, THR145H, TYR112B, TYR112H
• C-D: ALA110C, ALA114C, ALA115C, ALA121C, ALA123C, ALA157C, ALA15D, ALA173D, ALA179D, ALA191D, ALA199D, ALA202D, ALA203D, ALA205D, ALA214D, ALA33C, ALA34C, ALA58C, ALA62C, ALA65C, ALA72C, ALA90C, ALA94C, ALA95C, ARG134C, ARG171D, ARG18D, ARG217D, ASN28C, ASN70C, ASP148C, ASP175D, ASP201D, ASP210D, ASP40C, ASP71C, CYS176D, CYS181D, GLN116C, GLN138C, GLN144C, GLN151C, GLN192D, GLN193D, GLN209D, GLN212D, GLN59C, GLU182D, GLU208D, GLU2D, GLU66C, GLU91C, GLY113C, GLY117C, GLY124C, GLY180D, GLY213D, GLY35C, GLY67C, GLY92C, HIS150C, HIS150D, HIS156C, ILE135C, ILE184D, ILE195D, ILE19D, ILE220D, ILE31C, ILE32C, ILE78C, ILE96C, LEU118C, LEU119C, LEU122C, LEU149C, LEU152C, LEU153C, LEU16D, LEU174D, LEU177D, LEU178D, LEU186D, LEU22D, LEU39C, LEU3D, LEU43C, LEU75C, LEU93C, LYS154D, LYS206D, LYS36C, LYS37C, LYS74C, LYS85C, LYS97C, MET155C, MET194D, MET1D, MET50D, MET61C, MET68C, MET98C, PHE207D, PHE20D, PHE215D, PRO158C, PRO170D, PRO198D, PRO21D, PRO29C, PRO38C, PRO87C, SER120C, SER166C, SER17D, SER183D, SER196D, SER219D, SER30C, SER8C, THR109C, THR145C, THR147C, THR218D, THR27C, THR63C, THR64C, THR89C, TRP211D, TYR112C, TYR131C, TYR197D, VAL111C, VAL162D, VAL190D, VAL200D, VAL204D, VAL41C, VAL42C, VAL60C, VAL84C, VAL86C, VAL88C
• C-G: ALA199C, ALA199G, ALA202C, ALA202G, ALA203C, ALA203G, ASP201C, ASP201G, PRO198C, PRO198G, TYR197C, TYR197G, VAL200C, VAL200G
• C-H: ALA137C, ALA137H, ALA173C, ALA173H, ALA199C, ALA199H, ARG134C, ARG134H, ARG171C, ARG171H, ASN133C, ASN133H, ASP136C, ASP136H, ASP175C, ASP175H, ASP189C, ASP189H, GLN138C, GLN138H, GLN144C, GLN144H, GLN172C, GLN172H, GLN193C, GLN193H, GLY139C, GLY139H, GLY140C, GLY140H, GLY142C, GLY142H, ILE135C, ILE135H, ILE143C, ILE143H, ILE195C, ILE195H, LEU174C, LEU174H, LYS168C, LYS168H, MET194C, MET194H, PHE167C, PHE167H, PRO170C, PRO170H, PRO198C, PRO198H, SER141C, SER141H, SER196C, SER196H, THR169C, THR169H, TYR112C, TYR112H, TYR197C, TYR197H, VAL132C, VAL132H, VAL190C, VAL190H, VAL200C, VAL200H
• C-I: ALA114C, ALA114I, ALA115C, ALA115I, ALA137C, ALA137I, ASP148C, ASP148I, GLN116C, GLN116I, GLN138C, GLN138I, GLN144C, GLN144I, GLY113C, GLY113I, GLY139C, GLY139I, GLY140C, GLY140I, ILE135C, ILE135I, SER141C, SER141I, THR145C, THR145I, TYR112C, TYR112I
• D-E: ALA110D, ALA114D, ALA115D, ALA121D, ALA123D, ALA157D, ALA15E, ALA173E, ALA179E, ALA191E, ALA199E, ALA202E, ALA203E, ALA205E, ALA214E, ALA23E, ALA33D, ALA34D, ALA58D, ALA62D, ALA65D, ALA90D, ALA94D, ALA95D, ARG134D, ARG171E, ARG18E, ARG217E, ASN28D, ASP148D, ASP175E, ASP201E, ASP210E, ASP40D, ASP71D, CYS176E, CYS181E, GLN116D, GLN138D, GLN144D, GLN151D, GLN192E, GLN193E, GLN209E, GLN212E, GLN59D, GLU182E, GLU208E, GLU2E, GLU66D, GLU91D, GLY113D, GLY117D, GLY124D, GLY180E, GLY213E, GLY35D, GLY67D, GLY92D, HIS150D, HIS150E, HIS156D, ILE135D, ILE184E, ILE195E, ILE19E, ILE220E, ILE31D, ILE32D, ILE78D, ILE96D, LEU118D, LEU119D, LEU122D, LEU149D, LEU152D, LEU153D, LEU16E, LEU174E, LEU177E, LEU178E, LEU186E, LEU22E, LEU39D, LEU3E, LEU43D, LEU75D, LEU93D, LYS154E, LYS206E, LYS36D, LYS37D, LYS74D, LYS85D, LYS97D, MET155D, MET194E, MET1E, MET50E, MET61D, MET68D, MET98D, PHE207E, PHE20E, PHE215E, PRO158D, PRO170E, PRO198E, PRO21E, PRO29D, PRO38D, PRO87D, SER120D, SER166D, SER17E, SER183E, SER196E, SER219E, SER30D, THR109D, THR145D, THR147D, THR218E, THR27D, THR63D, THR64D, THR89D, TRP211E, TYR112D, TYR131D, TYR197E, VAL111D, VAL162E, VAL190E, VAL200E, VAL204E, VAL41D, VAL42D, VAL60D, VAL86D, VAL88D
• D-H: ALA199D, ALA199H, ALA202D, ALA202H, ALA203D, ALA203H, ASP201D, ASP201H, PRO198D, PRO198H, TYR197D, TYR197H, VAL200D, VAL200H
• D-I: ALA137D, ALA137I, ALA173D, ALA173I, ALA199D, ALA199I, ARG134D, ARG134I, ARG171D, ARG171I, ASN133D, ASN133I, ASP136D, ASP136I, ASP175D, ASP175I, ASP189D, ASP189I, GLN138D, GLN138I, GLN144D, GLN144I, GLN172D, GLN172I, GLN193D, GLN193I, GLY139D, GLY139I, GLY140D, GLY140I, GLY142D, GLY142I, ILE135D, ILE135I, ILE143D, ILE143I, ILE195D, ILE195I, LEU174D, LEU174I, LYS168D, LYS168I, MET194D, MET194I, PHE167D, PHE167I, PRO170D, PRO170I, PRO198D, PRO198I, SER141D, SER141I, SER166I, SER196D, SER196I, THR145D, THR145I, THR169D, THR169I, TYR112D, TYR112I, TYR197D, TYR197I, VAL132D, VAL132I, VAL190D, VAL190I, VAL200D, VAL200I
• D-J: ALA114D, ALA114J, ALA115D, ALA115J, ALA137D, ALA137J, ASP148D, ASP148J, GLN116D, GLN116J, GLN138D, GLN138J, GLN144D, GLN144J, GLY113D, GLY113J, GLY139D, GLY139J, GLY140D, GLY140J, ILE135D, ILE135J, SER141D, SER141J, THR145D, THR145J, TYR112D, TYR112J
• E-F: ALA114E, ALA114F, ALA115E, ALA115F, ALA137E, ASP148E, ASP148F, GLN116E, GLN116F, GLN138E, GLN138F, GLN144E, GLN144F, GLY113E, GLY113F, GLY139E, GLY139F, GLY140E, GLY140F, ILE135E, ILE135F, SER141E, SER141F, THR145E, THR145F, TYR112E, TYR112F
• E-I: ALA199E, ALA199I, ALA202E, ALA202I, ALA203E, ALA203I, ASP201E, ASP201I, LYS206I, PRO198E, PRO198I, TYR197E, TYR197I, VAL200E, VAL200I
• E-J: ALA137E, ALA137J, ALA173E, ALA173J, ALA199E, ALA199J, ARG134E, ARG134J, ARG171E, ARG171J, ASN133E, ASN133J, ASP136E, ASP136J, ASP175E, ASP175J, ASP189E, ASP189J, GLN138E, GLN138J, GLN144E, GLN144J, GLN172E, GLN172J, GLN193E, GLN193J, GLY139E, GLY139J, GLY140E, GLY140J, GLY142E, GLY142J, ILE135E, ILE135J, ILE143E, ILE143J, ILE195E, ILE195J, LEU174E, LEU174J, LYS168E, LYS168J, MET194E, MET194J, PHE167E, PHE167J, PRO170E, PRO170J, PRO198E, PRO198J, SER141E, SER141J, SER196E, SER196J, THR145E, THR145J, THR169E, THR169J, TYR112E, TYR112J, TYR197E, TYR197J, VAL132E, VAL132J, VAL190E, VAL190J, VAL200E, VAL200J
• F-G: ALA110G, ALA114G, ALA115G, ALA121G, ALA123G, ALA157G, ALA15F, ALA173F, ALA179F, ALA191F, ALA199F, ALA202F, ALA203F, ALA205F, ALA214F, ALA23F, ALA33G, ALA34G, ALA58G, ALA62G, ALA65G, ALA90G, ALA94G, ALA95G, ARG134G, ARG171F, ARG18F, ARG217F, ASN28G, ASN70G, ASP148G, ASP175F, ASP201F, ASP210F, ASP40G, ASP71G, CYS176F, CYS181F, GLN116G, GLN138G, GLN144G, GLN151G, GLN192F, GLN193F, GLN209F, GLN212F, GLN59G, GLU182F, GLU208F, GLU2F, GLU66G, GLU91G, GLY113G, GLY117G, GLY124G, GLY180F, GLY213F, GLY35G, GLY67G, GLY92G, HIS150F, HIS150G, HIS156G, ILE135G, ILE184F, ILE195F, ILE19F, ILE220F, ILE31G, ILE32G, ILE78G, ILE96G, LEU118G, LEU119G, LEU122G, LEU149G, LEU152G, LEU153G, LEU16F, LEU174F, LEU177F, LEU178F, LEU186F, LEU22F, LEU39G, LEU3F, LEU43G, LEU75G, LEU93G, LYS154F, LYS206F, LYS36G, LYS37G, LYS74G, LYS85G, LYS97G, MET155G, MET194F, MET1F, MET61G, MET68G, MET98G, PHE207F, PHE20F, PHE215F, PRO158G, PRO170F, PRO198F, PRO21F, PRO29G, PRO38G, PRO87G, SER120G, SER166G, SER17F, SER183F, SER196F, SER219F, SER30G, SER8G, THR109G, THR145G, THR147G, THR218F, THR27G, THR63G, THR64G, THR89G, TRP211F, TYR112G, TYR131G, TYR197F, VAL111G, VAL162F, VAL190F, VAL200F, VAL204F, VAL41G, VAL42G, VAL60G, VAL86G, VAL88G
• F-J: ALA110F, ALA114F, ALA115F, ALA121F, ALA123F, ALA125F, ALA157F, ALA15J, ALA173J, ALA179J, ALA191J, ALA199J, ALA202J, ALA203J, ALA205J, ALA214J, ALA23J, ALA33F, ALA34F, ALA58F, ALA62F, ALA65F, ALA72F, ALA90F, ALA94F, ALA95F, ARG134F, ARG171J, ARG18J, ARG217J, ARG76F, ASN28F, ASN70F, ASP148F, ASP175J, ASP201J, ASP210J, ASP40F, ASP71F, CYS176J, CYS181J, GLN116F, GLN138F, GLN144F, GLN151F, GLN192J, GLN193J, GLN209J, GLN212J, GLN59F, GLU182J, GLU208J, GLU2J, GLU66F, GLU91F, GLY113F, GLY117F, GLY124F, GLY180J, GLY213J, GLY35F, GLY67F, GLY92F, HIS150F, HIS150J, HIS156F, ILE135F, ILE184J, ILE195J, ILE19J, ILE220J, ILE31F, ILE32F, ILE78F, ILE82F, ILE96F, LEU118F, LEU119F, LEU122F, LEU149F, LEU152F, LEU153F, LEU16J, LEU174J, LEU177J, LEU178J, LEU186J, LEU22J, LEU39F, LEU3J, LEU43F, LEU73F, LEU75F, LEU93F, LYS154J, LYS206J, LYS36F, LYS37F, LYS74F, LYS85F, LYS97F, MET155F, MET194J, MET1J, MET61F, MET68F, MET98F, PHE207J, PHE20J, PHE215J, PRO158F, PRO170J, PRO198J, PRO21J, PRO29F, PRO38F, PRO87F, SER120F, SER166F, SER17J, SER183J, SER196J, SER219J, SER30F, THR109F, THR145F, THR147F, THR218J, THR27F, THR63F, THR64F, THR89F, TRP211J, TYR112F, TYR131F, TYR197J, VAL111F, VAL162J, VAL190J, VAL200J, VAL204J, VAL41F, VAL42F, VAL60F, VAL84F, VAL86F, VAL88F
• G-H: ALA110H, ALA114H, ALA115H, ALA121H, ALA123H, ALA157H, ALA15G, ALA173G, ALA179G, ALA191G, ALA199G, ALA202G, ALA203G, ALA205G, ALA214G, ALA23G, ALA33H, ALA34H, ALA58H, ALA62H, ALA65H, ALA72H, ALA90H, ALA94H, ALA95H, ARG134H, ARG171G, ARG18G, ARG217G, ASN28H, ASN70H, ASP148H, ASP175G, ASP201G, ASP210G, ASP40H, ASP71H, CYS176G, CYS181G, GLN116H, GLN138H, GLN144H, GLN151H, GLN192G, GLN193G, GLN209G, GLN212G, GLN59H, GLU182G, GLU208G, GLU2G, GLU66H, GLU91H, GLY113H, GLY117H, GLY124H, GLY180G, GLY213G, GLY35H, GLY67H, GLY92H, HIS150G, HIS150H, HIS156H, ILE135H, ILE184G, ILE195G, ILE19G, ILE220G, ILE31H, ILE32H, ILE78H, ILE96H, LEU118H, LEU119H, LEU122H, LEU149H, LEU152H, LEU153H, LEU16G, LEU174G, LEU177G, LEU178G, LEU186G, LEU22G, LEU39H, LEU3G, LEU43H, LEU75H, LEU93H, LYS100H, LYS154G, LYS206G, LYS36H, LYS37H, LYS74H, LYS85H, LYS97H, MET155H, MET194G, MET1G, MET50G, MET61H, MET68H, MET98H, PHE207G, PHE20G, PHE215G, PRO158H, PRO170G, PRO198G, PRO21G, PRO29H, PRO38H, PRO87H, SER120H, SER166H, SER17G, SER183G, SER196G, SER219G, SER30H, THR109H, THR145H, THR147H, THR218G, THR27H, THR63H, THR64H, THR89H, TRP211G, TYR112H, TYR131H, TYR197G, VAL111H, VAL190G, VAL200G, VAL204G, VAL41H, VAL42H, VAL60H, VAL84H, VAL86H, VAL88H
• H-I: ALA110I, ALA114I, ALA115I, ALA121I, ALA123I, ALA157I, ALA15H, ALA173H, ALA179H, ALA191H, ALA199H, ALA202H, ALA203H, ALA205H, ALA214H, ALA33I, ALA34I, ALA58I, ALA62I, ALA65I, ALA72I, ALA90I, ALA94I, ALA95I, ARG134I, ARG171H, ARG18H, ARG217H, ARG76I, ASN28I, ASN70I, ASP148I, ASP175H, ASP201H, ASP210H, ASP40I, ASP71I, CYS176H, CYS181H, GLN116I, GLN138I, GLN144I, GLN151I, GLN192H, GLN193H, GLN209H, GLN212H, GLN59I, GLU182H, GLU208H, GLU2H, GLU66I, GLU91I, GLY113I, GLY117I, GLY124I, GLY180H, GLY213H, GLY35I, GLY67I, GLY92I, HIS150H, HIS150I, HIS156I, ILE135I, ILE184H, ILE195H, ILE19H, ILE220H, ILE31I, ILE32I, ILE78I, ILE82I, ILE96I, LEU118I, LEU119I, LEU122I, LEU149I, LEU152I, LEU153I, LEU16H, LEU174H, LEU177H, LEU178H, LEU186H, LEU22H, LEU39I, LEU3H, LEU43I, LEU73I, LEU75I, LEU93I, LYS154H, LYS206H, LYS36I, LYS37I, LYS74I, LYS85I, LYS97I, MET155I, MET194H, MET1H, MET50H, MET61I, MET68I, MET98I, PHE207H, PHE20H, PHE215H, PRO158I, PRO170H, PRO198H, PRO21H, PRO29I, PRO38I, PRO87I, SER120I, SER166I, SER17H, SER183H, SER196H, SER219H, SER30I, THR109I, THR145I, THR147I, THR218H, THR27I, THR63I, THR64I, THR89I, TRP211H, TYR112I, TYR131I, TYR197H, VAL111I, VAL162H, VAL190H, VAL200H, VAL204H, VAL41I, VAL42I, VAL60I, VAL84I, VAL86I, VAL88I
• I-J: ALA110J, ALA114J, ALA115J, ALA121J, ALA123J, ALA157J, ALA15I, ALA173I, ALA179I, ALA191I, ALA199I, ALA202I, ALA203I, ALA205I, ALA214I, ALA33J, ALA34J, ALA58J, ALA62J, ALA65J, ALA72J, ALA90J, ALA94J, ALA95J, ARG134J, ARG171I, ARG18I, ARG217I, ARG76J, ASN28J, ASN70J, ASP148J, ASP175I, ASP201I, ASP210I, ASP40J, ASP71J, CYS176I, CYS181I, GLN116J, GLN138J, GLN144J, GLN151J, GLN192I, GLN193I, GLN209I, GLN212I, GLN59J, GLU182I, GLU208I, GLU2I, GLU66J, GLU91J, GLY113J, GLY117J, GLY124J, GLY180I, GLY213I, GLY35J, GLY67J, GLY92J, HIS150I, HIS150J, HIS156J, ILE135J, ILE184I, ILE195I, ILE19I, ILE220I, ILE31J, ILE32J, ILE78J, ILE96J, LEU118J, LEU119J, LEU122J, LEU149J, LEU152J, LEU153J, LEU16I, LEU174I, LEU177I, LEU178I, LEU186I, LEU22I, LEU39J, LEU3I, LEU43J, LEU73J, LEU75J, LEU93J, LYS154I, LYS206I, LYS36J, LYS37J, LYS74J, LYS85J, LYS97J, MET155J, MET194I, MET1I, MET61J, MET68J, MET98J, PHE207I, PHE20I, PHE215I, PRO158J, PRO170I, PRO198I, PRO21I, PRO29J, PRO38J, PRO87J, SER120J, SER166J, SER17I, SER183I, SER196I, SER219I, SER30J, THR109J, THR145J, THR147J, THR218I, THR27J, THR63J, THR64J, THR89J, TRP211I, TYR112J, TYR131J, TYR197I, VAL111J, VAL190I, VAL200I, VAL204I, VAL41J, VAL42J, VAL60J, VAL69J, VAL84J, VAL86J, VAL88J