1L6L

structures of apolipoprotein a-ii and a lipid surrogate complex provide insights into apolipoprotein-lipid interactions

• Total interactions analyzed: 496
• Total true interactions: 152
• Strongest Interaction:
  • Chains: E-G
  • Int. Res.: 17
  • Norm. En. per Res.: -7.6333
• Hub Node: C(10)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-16.7706	-18.5408	666.955	631.6436	103	17	3	7491	2	21	32
A-C	-23.795	0.0	-37.7332	-61.5282	20	12	2	2181	0	1	2
A-D	0.0	0.0	-1.7636	-1.7636	11	0	0	200	0	0	0
A-I	0.0	0.0	-1.9905	-1.9905	27	0	0	242	0	7	7
A-J	0.0	13.2887	-92.6232	-79.3345	76	5	1	4317	0	9	10
A-L	0.0	0.0	-3.0209	-3.0209	7	0	0	260	0	0	0
A-P	0.0	0.0	-1.7734	-1.7734	7	0	0	208	0	0	0
B-C	0.0	1.1249	-19.9287	-18.8038	14	0	0	697	0	1	2
B-D	-21.3125	2.1599	-35.6231	-54.7758	18	8	0	1216	0	1	2
B-I	0.0	24.0776	-192.211	-168.1334	104	25	5	8736	1	16	19
B-J	0.0	0.0	-12.8661	-12.8661	32	1	0	574	0	2	3
B-K	-8.0629	0.0	-7.765	-15.828	5	0	0	295	0	0	0
B-L	0.0	0.0	-0.0035	-0.0035	3	0	0	5	0	0	0
B-W	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	0	0
B-Y	0.0	-1.851	-1.6119	-3.4629	12	0	0	221	0	2	2
C-D	-8.6151	-7.5774	642.972	626.7795	90	13	1	6344	2	20	29
C-E	-20.5842	0.0	-82.628	-103.2122	21	14	2	2920	0	0	1
C-F	0.0	0.0	-1.0897	-1.0897	6	0	0	117	0	0	0
C-H	0.0	0.0	-3.5734	-3.5734	10	0	0	249	0	1	1
C-I	0.0	0.0	-0.0161	-0.0161	2	0	0	2	0	0	0
C-J	-31.7791	0.0	-58.2235	-90.0026	15	25	0	2470	0	0	0
C-K	0.0	29.7079	-32.0459	-2.338	37	3	0	1502	0	4	6
C-L	-7.4968	15.8783	-150.645	-142.2634	111	5	8	7470	0	19	22
C-N	0.0	0.0	-0.2533	-0.2533	4	0	0	19	0	0	0
C-P	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	0	0
D-E	0.0	0.0	-0.0056	-0.0056	5	0	0	3	0	0	1
D-F	-11.973	8.8498	-123.41	-126.5332	23	16	0	3327	0	1	1
D-I	-10.9933	0.0	-10.5438	-21.5371	7	0	0	326	0	0	0
D-J	0.0	0.0	-1.0079	-1.0079	6	0	0	150	0	0	0
D-K	-16.2982	45.6386	-144.814	-115.4736	105	34	10	7862	1	15	15
D-L	0.0	0.0	-19.1575	-19.1575	34	1	0	952	0	4	6
D-M	0.0	0.0	-18.542	-18.542	13	2	2	764	0	0	0
D-N	0.0	0.0	-0.0147	-0.0147	2	0	0	9	0	0	0
D-W	0.0	0.0	-0.4104	-0.4104	7	0	0	64	0	0	3
E-F	-11.0398	-17.3371	610.522	582.1451	100	17	1	7533	3	26	29
E-G	-33.2307	0.0	-96.5359	-129.7666	17	12	1	2601	0	1	1
E-H	0.0	0.0	-3.556	-3.556	9	0	1	375	0	0	0
E-K	0.0	0.0	-2.2511	-2.2511	6	0	0	116	0	0	0
E-L	0.0	0.0	-7.8126	-7.8126	9	0	1	535	0	0	0
E-M	0.0	13.0351	-31.8067	-18.7716	37	8	0	1509	0	8	8
E-N	-20.3116	6.2769	-331.643	-345.6778	134	32	13	14319	2	31	30
E-P	0.0	0.0	-15.9613	-15.9613	7	1	0	646	0	0	0
E-Q	0.0	0.0	-0.0008	-0.0008	2	0	0	2	0	0	0
F-H	-41.5449	0.0	-64.2662	-105.8111	18	10	0	2106	0	1	2
F-J	-16.6614	21.6601	-129.567	-124.5683	63	10	2	5621	2	16	15
F-K	0.0	0.0	-2.6046	-2.6046	6	0	0	313	0	1	0
F-L	0.0	0.0	-0.3128	-0.3128	2	0	0	53	0	0	0
F-M	-21.8827	5.398	-123.812	-140.2967	91	6	1	6224	3	15	19
F-N	-4.589	0.0	-22.0655	-26.6545	39	0	0	947	0	5	7
F-P	0.0	0.0	-0.4307	-0.4307	4	0	0	73	0	0	0
G-H	-6.3932	-23.0113	588.851	559.4465	112	13	3	7662	2	21	33
G-M	0.0	0.0	-4.469	-4.469	9	0	0	348	0	0	0
G-N	0.0	0.0	-36.9262	-36.9262	16	4	0	1470	0	0	0
G-P	0.0	4.9347	-11.1038	-6.1691	34	0	0	758	0	4	6
G-Q	-4.4844	18.8875	-145.636	-131.2329	85	1	2	6553	1	10	15
H-J	0.0	0.0	-0.0154	-0.0154	2	0	0	3	0	0	0
H-L	0.0	0.0	-1.0139	-1.0139	12	0	0	131	0	0	0
H-M	-3.517	0.0	-52.9216	-56.4386	11	10	1	1615	0	0	0
H-P	-3.1019	-1.4452	-86.1154	-90.6625	88	5	3	4864	2	9	13
H-Q	0.0	19.8028	-6.3407	13.4621	27	0	0	582	0	4	6
I-J	-6.4446	7.9474	612.76	614.2628	99	19	1	7201	1	22	32
I-K	-13.8614	0.0	-1.6267	-15.4881	5	8	0	406	0	0	0
I-M	0.0	0.0	-0.003	-0.003	2	0	0	1	0	0	1
I-W	0.0	0.0	-2.2488	-2.2488	6	0	0	212	0	0	0
J-K	0.0	0.0	-0.3638	-0.3638	3	0	0	51	0	0	0
J-L	-5.8508	0.0	-17.6195	-23.4703	7	1	0	597	0	0	0
J-M	-6.423	-13.1789	-35.7874	-55.3893	36	5	0	1910	1	11	13
J-P	0.0	0.0	-0.0055	-0.0055	3	0	0	5	0	1	1
K-L	-2.4986	-1.5883	601.283	597.196	112	12	1	8083	0	20	30
K-M	-8.7812	0.0	-7.2995	-16.0807	9	3	0	530	0	0	0
K-W	0.0	0.0	-1.9693	-1.9693	20	0	0	357	0	5	3
K-6	0.0	0.0	-0.9265	-0.9265	11	0	0	182	0	3	2
L-M	0.0	0.0	-0.007	-0.007	3	0	0	5	0	0	0
L-N	-11.663	0.0	-23.2943	-34.9573	6	3	0	633	0	0	0
L-P	-9.0688	-12.4911	-1.3442	-22.9041	15	1	0	145	1	6	8
M-N	-4.7703	-14.2632	637.998	618.9645	108	15	1	6828	2	23	30
M-P	-30.0494	0.0	-15.8493	-45.8987	8	5	0	574	0	0	0
N-P	0.0	0.0	-2.2835	-2.2835	5	0	0	172	0	0	0
N-Q	-6.4376	0.0	-15.5985	-22.0361	8	1	0	482	0	0	0
P-Q	0.0	10.3894	638.42	648.8094	103	9	1	6651	0	24	30
S-T	-18.0658	-23.0899	615.363	574.2074	106	8	2	7519	2	22	32
S-U	-30.458	0.0	-115.597	-146.055	22	11	0	3233	0	1	2
S-V	0.0	0.0	-21.9709	-21.9709	17	1	1	1173	0	0	0
S-1	0.0	0.0	-1.4331	-1.4331	30	0	0	258	0	6	7
S-2	0.0	7.4189	-47.3297	-39.9108	68	2	0	2901	0	8	10
S-3	0.0	0.0	-0.0019	-0.0019	2	0	0	1	0	0	0
S-4	0.0	0.0	-2.4601	-2.4601	9	0	0	258	0	0	0
T-U	0.0	0.0	-4.5686	-4.5686	8	0	0	151	0	0	2
T-V	-37.6061	4.5792	138.918	105.8911	17	42	0	1780	0	1	2
T-1	0.0	21.0987	-182.42	-161.3213	105	7	9	9036	1	17	20
T-2	0.0	0.0	-7.6176	-7.6176	26	0	0	510	0	2	3
T-3	0.0	0.0	-8.8544	-8.8544	5	0	0	508	0	0	0
T-4	0.0	0.0	-0.7741	-0.7741	5	0	0	103	0	0	0
U-V	-7.7482	-6.0292	663.878	650.1006	94	10	3	5903	2	19	26
U-W	-6.1407	0.0	-49.7857	-55.9264	19	12	1	2198	0	0	1
U-X	0.0	0.0	-0.696	-0.696	8	0	0	153	0	0	0
U-Z	0.0	0.0	-6.399	-6.399	13	0	0	342	0	2	2
U-2	0.0	0.0	-10.8898	-10.8898	9	0	0	484	0	1	1
U-3	0.0	31.9202	-24.792	7.1282	31	0	0	1124	0	2	4
U-4	-6.7314	13.1333	-162.08	-155.6781	111	4	10	8124	0	17	19
U-7	0.0	0.0	-0.0031	-0.0031	2	0	0	3	0	0	0
V-W	0.0	0.0	-13.9572	-13.9572	9	0	0	539	0	0	2
V-X	-7.0959	2.1977	-98.9003	-103.7985	23	12	1	3657	0	1	1
V-1	0.0	0.0	-0.0929	-0.0929	6	0	0	35	0	0	0
V-2	0.0	0.0	-0.0025	-0.0025	3	0	0	7	0	0	0
V-3	0.0	11.2647	-140.319	-129.0543	100	4	9	6809	1	15	14
V-4	0.0	0.0	-10.7937	-10.7937	38	4	0	814	0	4	6
V-5	0.0	0.0	-10.4077	-10.4077	10	0	1	526	0	0	0
V-6	0.0	0.0	-0.0085	-0.0085	3	0	0	7	0	0	0
W-X	-6.0697	-18.1958	593.943	569.6775	109	11	2	7965	2	26	31
W-Y	-13.3866	0.0	-113.693	-127.0796	17	8	1	2722	0	1	1
W-Z	0.0	0.0	-2.5004	-2.5004	10	0	0	385	0	0	0
W-4	0.0	0.0	-17.9429	-17.9429	11	0	0	880	0	0	0
W-5	0.0	11.9222	-9.2546	2.6677	37	0	0	754	0	8	7
W-6	-24.4876	9.3055	-284.466	-299.6481	130	10	10	12483	2	33	30
W-7	0.0	0.0	-16.8206	-16.8206	8	1	0	739	0	0	0
W-8	0.0	0.0	-0.0613	-0.0613	2	0	0	21	0	0	0
X-Y	0.0	0.0	-0.3668	-0.3668	4	0	0	35	0	0	1
X-Z	-18.3349	0.0	-61.8544	-80.1893	18	8	0	2182	0	1	1
X-2	-17.7596	22.079	-134.788	-130.4687	63	10	2	5663	2	15	14
X-3	0.0	0.0	-0.404	-0.404	3	0	0	77	0	1	0
X-5	-15.7922	10.4914	-124.643	-129.9437	90	3	1	6191	4	15	18
X-6	-4.4211	0.0	-17.6967	-22.1178	32	0	0	707	0	6	6
X-7	0.0	0.0	-2.9288	-2.9288	7	0	0	216	0	0	0
Y-Z	-2.9663	-18.816	601.944	580.1617	108	15	3	7730	2	23	32
Y-5	0.0	0.0	-0.0018	-0.0018	2	0	0	2	0	0	0
Y-6	0.0	0.0	-17.6804	-17.6804	10	3	0	1031	0	1	0
Y-7	0.0	4.983	-13.5782	-8.5952	29	0	0	770	0	3	5
Y-8	-6.1689	10.9305	-93.765	-89.0034	81	2	0	4241	0	11	13
Z-2	0.0	0.0	-0.0006	-0.0006	2	0	0	2	0	0	0
Z-4	0.0	0.0	-1.4773	-1.4773	11	0	0	188	0	0	0
Z-5	0.0	0.0	-12.8575	-12.8575	6	0	0	588	0	0	0
Z-7	0.0	0.0	-55.0871	-55.0871	75	0	3	3658	0	8	11
Z-8	0.0	6.7004	-3.6739	3.0265	28	0	0	331	0	4	6
1-2	-4.7212	7.8196	631.936	635.0344	94	12	1	6563	2	22	29
1-3	-10.1556	0.0	-12.4505	-22.6061	8	4	0	526	0	0	0
1-5	0.0	0.0	-0.0546	-0.0546	2	0	0	11	0	0	1
2-3	0.0	0.0	-2.5002	-2.5002	5	0	0	152	0	0	0
2-4	0.0	0.0	-15.9817	-15.9817	8	14	0	741	0	0	0
2-5	-7.0103	-12.0773	-15.5904	-34.678	34	1	0	993	1	9	10
2-7	0.0	0.0	-0.0164	-0.0164	5	0	0	16	0	1	0
3-4	0.0	5.0252	590.875	595.9002	105	22	2	7586	0	23	28
3-5	-26.4054	0.0	-34.5606	-60.966	10	7	0	867	0	0	0
3-6	0.0	0.0	-0.1425	-0.1425	6	0	0	58	0	0	0
4-5	0.0	0.0	-0.0014	-0.0014	2	0	0	1	0	0	0
4-6	-6.4424	0.0	-29.7858	-36.2282	9	10	0	781	0	0	0
4-7	0.0	0.0	-0.0218	-0.0218	8	0	0	9	0	2	3
5-6	0.0	13.9106	626.57	640.4806	94	18	2	6497	0	22	25
5-7	-19.4978	0.0	-25.5919	-45.0897	7	2	0	643	0	0	0
6-7	-9.0389	0.0	-18.9058	-27.9447	13	1	0	785	0	0	0
6-8	-3.0358	0.0	-22.4485	-25.4843	7	2	0	480	0	0	0
7-8	0.0	10.1999	666.037	676.2369	88	9	2	4719	1	18	25

Interface residues

• A-B: ALA36B, ALA38A, ALA38B, ALA56A, ALA56B, ASN62B, ASP24B, CYS6A, CYS6B, GLN13A, GLN13B, GLN16A, GLN35B, GLN48A, GLN48B, GLN73A, GLU27A, GLU27B, GLU33A, GLU37B, GLU43A, GLU43B, GLU47A, GLU47B, GLU4A, GLU4B, GLU59A, GLU59B, GLU69A, GLU69B, GLU8A, GLU8B, GLY22A, GLY71A, GLY71B, ILE53A, ILE53B, LEU10A, LEU10B, LEU25B, LEU34A, LEU49A, LEU49B, LEU52A, LEU52B, LEU60A, LEU60B, LEU64A, LEU70A, LEU70B, LYS23A, LYS28B, LYS30A, LYS39A, LYS39B, LYS44A, LYS44B, LYS46A, LYS46B, LYS54A, LYS54B, LYS55A, LYS55B, MET26A, PHE15A, PHE42A, PHE63A, PHE63B, PHE67A, PHE67B, PRO32B, PRO51B, PRO5A, PRO5B, PRO74B, SER12A, SER31A, SER31B, SER40A, SER40B, SER45A, SER45B, SER65B, SER9A, SER9B, THR17B, THR19A, THR50B, THR58B, THR72A, TYR14B, TYR21B, TYR41A, TYR41B, TYR66A, TYR66B, VAL11A, VAL11B, VAL29A, VAL61A, VAL68A, VAL7A, VAL7B
• A-C: ALA2C, ALA75A, CYS6C, GLN13C, GLN73A, GLN77A, GLU4C, GLU69A, GLU8C, GLY71A, LEU10C, LYS3C, PRO5C, PRO74A, SER9C, THR72A, THR76A, VAL11C, VAL68A, VAL7C
• A-D: ALA75A, CYS6D, GLN13D, GLN73A, GLY71A, LEU10D, PRO5D, SER9D, THR72A, VAL68A, VAL7D
• A-I: ALA38A, GLN48I, GLU33A, GLU33I, GLU37A, GLU4I, GLU59A, GLU59I, GLU8A, GLU8I, LEU25I, LEU49A, LEU52A, LEU52I, LEU60A, LYS39A, LYS55A, LYS55I, PHE15A, PHE42I, PHE63A, PHE63I, TYR41A, TYR41I, VAL11A, VAL29I, VAL7I
• A-J: ALA38A, ALA38J, ALA56J, ALA75A, ALA75J, CYS6J, GLN48A, GLN48J, GLN73A, GLN73J, GLN77A, GLN77J, GLU33A, GLU33J, GLU37A, GLU37J, GLU4J, GLU59A, GLU59J, GLU69A, GLU8J, GLY22A, GLY71A, GLY71J, LEU10J, LEU25A, LEU25J, LEU49A, LEU49J, LEU52A, LEU52J, LEU60A, LEU60J, LEU64J, LEU70A, LEU70J, LYS23A, LYS28J, LYS30A, LYS44A, LYS55A, LYS55J, MET26A, PHE15A, PHE15J, PHE42J, PHE63A, PHE63J, PHE67A, PHE67J, PRO32A, PRO74A, PRO74J, SER40A, SER45A, SER45J, THR19A, THR72A, THR72J, THR76A, THR76J, TYR14A, TYR14J, TYR21A, TYR21J, TYR41A, TYR41J, TYR66A, TYR66J, VAL11A, VAL11J, VAL18A, VAL18J, VAL29A, VAL29J, VAL7J
• A-L: ALA75A, GLN77A, GLU4L, GLU8L, LYS3L, THR76A, VAL7L
• A-P: ALA36P, GLN35P, GLN77A, GLU37P, LYS44P, SER40P, THR76A
• B-C: ALA2C, ALA75B, GLN73B, GLN77B, GLU4C, GLU69B, GLY71B, LEU70B, LYS3C, PRO5C, PRO74B, THR72B, THR76B, VAL68B
• B-D: ALA2D, ALA75B, CYS6D, GLN73B, GLN77B, GLU4D, GLU69B, GLU8D, GLY71B, LEU70B, LYS3D, PRO5D, PRO74B, SER9D, THR72B, THR76B, VAL68B, VAL7D
• B-I: ALA36I, ALA38B, ALA56B, ALA56I, ALA75B, ALA75I, ASN62I, GLN48B, GLN48I, GLN73B, GLN73I, GLN77B, GLN77I, GLU33B, GLU37B, GLU37I, GLU43B, GLU43I, GLU47B, GLU47I, GLU4I, GLU59B, GLU59I, GLU69I, GLU8I, GLY22B, GLY22I, GLY57I, GLY71B, GLY71I, ILE53B, ILE53I, LEU10B, LEU25B, LEU25I, LEU49B, LEU49I, LEU52B, LEU52I, LEU60B, LEU60I, LEU64B, LEU70B, LEU70I, LYS23I, LYS28B, LYS28I, LYS39B, LYS44B, LYS44I, LYS46B, LYS46I, LYS54B, LYS54I, LYS55B, LYS55I, MET26B, PHE15B, PHE15I, PHE42B, PHE42I, PHE63B, PHE63I, PHE67B, PHE67I, PRO32B, PRO32I, PRO51B, PRO51I, PRO5I, PRO74B, PRO74I, SER12I, SER40I, SER45B, SER45I, THR19B, THR19I, THR50B, THR50I, THR58I, THR72B, THR72I, THR76B, THR76I, TYR14B, TYR14I, TYR21B, TYR21I, TYR41B, TYR41I, TYR66B, TYR66I, VAL11B, VAL18B, VAL18I, VAL29B, VAL29I, VAL61B, VAL61I, VAL68B, VAL68I, VAL7B, VAL7I
• B-J: ALA75J, GLN48B, GLN48J, GLN73J, GLN77B, GLN77J, GLU59B, GLU59J, GLY71B, LEU52J, LEU60B, LEU70B, LEU70J, LYS28B, LYS44B, LYS44J, LYS55B, LYS55J, PHE63B, PHE63J, PHE67B, PHE67J, PRO74B, PRO74J, THR76J, TYR14J, TYR21B, TYR21J, TYR41B, TYR41J, TYR66B, TYR66J
• B-K: ALA2K, GLN77B, GLU4K, LYS3K, THR76B
• B-L: ALA2L, GLN77B, LYS3L
• B-W: THR76B, TYR14W
• B-Y: ASP24Y, GLN13B, GLN16B, GLN35Y, GLU27Y, GLU8B, LEU25Y, LYS28Y, PHE15B, SER12B, SER31Y, SER9B
• C-D: ALA2D, ALA38D, ALA56C, ALA56D, ASN62D, ASP24D, CYS6C, CYS6D, GLN13D, GLN16C, GLN35D, GLN48C, GLN48D, GLU27C, GLU27D, GLU33C, GLU43C, GLU43D, GLU47C, GLU47D, GLU4C, GLU4D, GLU59C, GLU59D, GLU8C, GLU8D, GLY22C, GLY57D, GLY71C, ILE53C, LEU10C, LEU10D, LEU25D, LEU34C, LEU49C, LEU49D, LEU52C, LEU52D, LEU60C, LEU60D, LEU64C, LEU70C, LEU70D, LYS23C, LYS28D, LYS30C, LYS3C, LYS3D, LYS44C, LYS44D, LYS46C, LYS46D, LYS54C, LYS54D, LYS55C, LYS55D, MET26C, PHE15C, PHE42C, PHE63C, PHE63D, PHE67C, PRO32D, PRO51D, PRO5C, PRO5D, SER12C, SER31C, SER31D, SER40D, SER45C, SER45D, SER65D, SER9C, SER9D, THR17D, THR19C, THR58D, TYR14D, TYR21D, TYR41C, TYR41D, TYR66D, VAL11C, VAL11D, VAL18D, VAL29C, VAL61C, VAL7C, VAL7D
• C-E: ALA2E, ALA75C, CYS6E, GLN13E, GLN73C, GLN77C, GLU4E, GLU69C, GLU8E, GLY71C, LEU10E, LEU70C, LYS3E, PRO5E, PRO74C, SER9E, THR72C, THR76C, VAL11E, VAL68C, VAL7E
• C-F: CYS6F, GLU4F, GLY71C, PRO5F, THR72C, VAL68C
• C-H: ILE53H, LEU10C, LEU25C, LYS46H, LYS54H, PHE42H, THR50H, TYR14C, TYR21C, VAL18C
• C-I: GLN77I, GLU4C
• C-J: ALA2C, ALA75J, CYS6C, GLN73J, GLN77J, GLU4C, GLU8C, LEU10C, LYS3C, PRO5C, PRO74J, SER9C, THR72J, THR76J, VAL7C
• C-K: ALA56K, CYS6C, GLN48C, GLU4C, GLU4K, GLU59C, GLU59K, GLU8C, GLU8K, GLY71K, LEU49K, LEU52C, LEU52K, LEU60C, LEU60K, LEU64K, LEU70C, LEU70K, LYS3C, LYS3K, LYS55C, LYS55K, PHE15K, PHE63C, PHE63K, PHE67C, PHE67K, PRO5C, SER45C, TYR41C, TYR41K, TYR66C, TYR66K, VAL11C, VAL11K, VAL7C, VAL7K
• C-L: ALA2C, ALA2L, ALA36C, ALA38C, ALA38L, ALA56C, ALA56L, ASN62C, ASP20C, CYS6C, CYS6L, GLN13L, GLN16C, GLN16L, GLN48C, GLN48L, GLN73C, GLN77C, GLU33C, GLU33L, GLU37C, GLU37L, GLU43C, GLU43L, GLU47C, GLU47L, GLU4L, GLU59C, GLU59L, GLU69C, GLU69L, GLU8C, GLU8L, GLY22C, GLY22L, GLY71L, ILE53L, LEU10L, LEU25C, LEU25L, LEU34L, LEU49C, LEU49L, LEU52C, LEU52L, LEU60C, LEU60L, LEU64L, LEU70C, LYS23C, LYS23L, LYS28L, LYS30C, LYS39C, LYS39L, LYS3C, LYS3L, LYS44C, LYS44L, LYS46C, LYS46L, LYS55C, LYS55L, MET26C, MET26L, PHE15C, PHE15L, PHE42C, PHE42L, PHE63C, PHE63L, PHE67C, PHE67L, PRO32C, PRO32L, PRO51C, PRO51L, PRO5C, PRO5L, PRO74C, SER12C, SER12L, SER40C, SER40L, SER45C, SER45L, SER65C, SER65L, THR19C, THR19L, THR50C, THR50L, THR58C, THR72L, TYR14C, TYR14L, TYR21C, TYR21L, TYR41C, TYR41L, TYR66C, TYR66L, VAL11C, VAL11L, VAL18C, VAL18L, VAL29C, VAL29L, VAL68L, VAL7C, VAL7L
• C-N: ALA75C, GLN77C, GLU8N, THR76C
• C-P: ALA36P, LYS3C
• D-E: CYS6E, GLN73D, GLU4E, LEU70D, PRO74D
• D-F: ALA2F, ALA75D, CYS6F, GLN73D, GLN77D, GLU4F, GLU69D, GLY71D, LEU10F, LEU70D, LYS3F, PHE67D, PRO5F, PRO74D, SER12F, SER65D, SER9F, THR72D, THR76D, TYR66D, VAL11F, VAL68D, VAL7F
• D-I: ALA2D, ALA75I, GLN77I, GLU4D, LYS3D, PRO5D, THR76I
• D-J: ALA2D, ALA75J, CYS6D, GLN77J, LYS3D, THR76J
• D-K: ALA2D, ALA2K, ALA36K, ALA38D, ALA75D, ALA75K, ASP20K, CYS6D, CYS6K, GLN13D, GLN16D, GLN16K, GLN35D, GLN35K, GLN48D, GLN48K, GLN77D, GLN77K, GLU33D, GLU33K, GLU47D, GLU47K, GLU4D, GLU4K, GLU59D, GLU59K, GLU8D, GLU8K, GLY22D, GLY22K, LEU10D, LEU10K, LEU25D, LEU25K, LEU34D, LEU34K, LEU49D, LEU49K, LEU52D, LEU52K, LEU60D, LEU60K, LEU64D, LEU70D, LYS23K, LYS28D, LYS28K, LYS30D, LYS30K, LYS39D, LYS3D, LYS3K, LYS44D, LYS44K, LYS46D, LYS46K, LYS55D, LYS55K, MET26D, MET26K, PHE15D, PHE15K, PHE42D, PHE63D, PHE63K, PHE67D, PRO32D, PRO32K, PRO51K, PRO5D, PRO5K, PRO74D, PRO74K, SER12D, SER12K, SER31D, SER31K, SER40D, SER45D, SER45K, SER9K, THR17D, THR17K, THR19D, THR19K, THR58K, THR72D, THR76D, THR76K, TYR14D, TYR14K, TYR21D, TYR21K, TYR41D, TYR41K, TYR66D, TYR66K, VAL11D, VAL11K, VAL18D, VAL18K, VAL29D, VAL29K, VAL7D, VAL7K
• D-L: ALA2L, ALA38D, ASP24L, CYS6L, GLN48D, GLN48L, GLN77D, GLU37L, LEU10L, LEU25D, LEU25L, LYS28D, LYS28L, LYS3D, LYS44D, LYS44L, PRO32D, PRO5L, SER40D, SER45L, THR17D, THR17L, THR76L, TYR14D, TYR14L, TYR21D, TYR21L, TYR41D, TYR41L, VAL18D, VAL18L, VAL29D, VAL29L, VAL7D
• D-M: ALA75D, CYS6M, GLN73D, GLN77D, GLU8M, LEU10M, LYS3M, PRO5M, PRO74D, SER9M, THR76D, VAL11M, VAL7M
• D-N: PRO74D, VAL7N
• D-W: ALA2D, ASP24W, GLU4D, LYS39W, LYS3D, PHE15D, TYR21W
• E-F: ALA2F, ALA36F, ALA38F, ALA56E, ALA56F, ASN62F, ASP20F, ASP24F, CYS6E, CYS6F, GLN13E, GLN13F, GLN16E, GLN35E, GLN35F, GLN48E, GLN48F, GLN73E, GLU27F, GLU33E, GLU37F, GLU43E, GLU43F, GLU47E, GLU47F, GLU4E, GLU4F, GLU59E, GLU59F, GLU69F, GLU8E, GLY22E, GLY57F, GLY71E, ILE53E, ILE53F, LEU10E, LEU10F, LEU25F, LEU34E, LEU49E, LEU49F, LEU52E, LEU52F, LEU60E, LEU60F, LEU64E, LEU64F, LEU70E, LEU70F, LYS23E, LYS23F, LYS28E, LYS28F, LYS30E, LYS39F, LYS3F, LYS44E, LYS44F, LYS46E, LYS46F, LYS54E, LYS55E, LYS55F, MET26E, MET26F, PHE15E, PHE42E, PHE63E, PHE63F, PHE67E, PHE67F, PRO32E, PRO32F, PRO51F, PRO5E, PRO5F, SER12E, SER31E, SER31F, SER40F, SER45E, SER45F, SER65E, SER9E, THR17F, THR19E, THR50E, THR58F, THR72E, TYR14F, TYR21F, TYR41E, TYR41F, TYR66F, VAL29E, VAL61E, VAL68E, VAL7E, VAL7F
• E-G: ALA2G, ALA75E, CYS6G, GLN73E, GLN77E, GLU4G, GLU69E, GLU8G, GLY71E, LEU10G, LEU70E, LYS3G, PRO5G, SER9G, THR72E, THR76E, VAL7G
• E-H: ALA2H, ALA75E, CYS6H, GLN73E, GLY71E, PRO5H, THR72E, THR76E, VAL7H
• E-K: ALA75K, GLN73K, GLU4E, LYS3E, PRO5E, PRO74K
• E-L: ALA2E, ALA75L, GLN73L, GLN77L, GLU4E, LYS3E, PRO5E, THR72L, THR76L
• E-M: ALA38M, ALA75E, ALA75M, GLN48E, GLN73E, GLN77E, GLN77M, GLU33E, GLU33M, GLU37M, GLU59E, GLU59M, GLY71E, LEU34E, LEU34M, LEU49M, LEU52E, LEU52M, LEU60E, LEU60M, LEU70E, LYS30E, LYS30M, LYS55E, LYS55M, PHE15E, PHE15M, PHE42M, PHE63E, PHE63M, PHE67E, PHE67M, THR72E, THR76E, THR76M, TYR41M, VAL29E
• E-N: ALA2N, ALA36N, ALA38N, ALA56E, ALA56N, ALA75E, ALA75N, ASN62E, ASP20N, ASP24E, ASP24N, GLN13N, GLN16E, GLN16N, GLN35E, GLN35N, GLN48E, GLN48N, GLN73E, GLN73N, GLN77E, GLN77N, GLU27E, GLU27N, GLU33E, GLU33N, GLU37N, GLU43E, GLU43N, GLU47E, GLU47N, GLU4E, GLU4N, GLU59E, GLU59N, GLU69E, GLU69N, GLU8E, GLU8N, GLY22E, GLY22N, GLY57E, GLY57N, GLY71E, GLY71N, ILE53E, ILE53N, LEU10N, LEU25E, LEU25N, LEU34E, LEU34N, LEU49E, LEU49N, LEU52E, LEU52N, LEU60E, LEU60N, LEU64E, LEU64N, LEU70E, LEU70N, LYS23E, LYS23N, LYS28E, LYS28N, LYS30E, LYS30N, LYS39N, LYS3E, LYS3N, LYS44E, LYS44N, LYS46E, LYS46N, LYS54E, LYS54N, LYS55E, LYS55N, MET26E, MET26N, PHE15E, PHE15N, PHE42E, PHE42N, PHE63E, PHE63N, PHE67E, PHE67N, PRO32E, PRO32N, PRO51E, PRO51N, PRO74N, SER12E, SER12N, SER31E, SER31N, SER40E, SER40N, SER45E, SER45N, SER65N, THR17E, THR17N, THR19E, THR19N, THR50E, THR50N, THR58E, THR58N, THR72E, THR72N, THR76E, THR76N, TYR14E, TYR14N, TYR21E, TYR21N, TYR41E, TYR41N, TYR66E, TYR66N, VAL11E, VAL11N, VAL18E, VAL18N, VAL29E, VAL29N, VAL61N, VAL68E, VAL68N, VAL7E, VAL7N
• E-P: ALA2P, ALA75E, GLN77E, GLU4P, LYS3P, PRO5P, THR76E
• E-Q: GLN77E, LYS3Q
• F-H: ALA2H, ALA75F, CYS6H, GLN73F, GLN77F, GLU4H, GLU69F, GLU8H, GLY71F, LEU10H, LEU70F, LYS3H, PRO5H, PRO74F, SER9H, THR72F, THR76F, VAL7H
• F-J: ALA36F, ALA36J, ALA38F, ASP20J, ASP24J, GLN13J, GLN16J, GLN35F, GLN35J, GLN48F, GLU27F, GLU27J, GLU33F, GLU33J, GLU43F, GLU47F, GLU4J, GLU8J, GLY22F, GLY22J, ILE53F, LEU25F, LEU34F, LEU34J, LEU49F, LEU52F, LEU64F, LYS23F, LYS23J, LYS30F, LYS30J, LYS39F, LYS44F, LYS46F, LYS46J, LYS54F, MET26F, MET26J, PHE15F, PHE15J, PHE42F, PHE42J, PRO32F, PRO32J, PRO51F, SER12J, SER31F, SER31J, SER45F, THR17J, THR19F, THR19J, THR50F, TYR14F, TYR21J, TYR41F, VAL11F, VAL11J, VAL18F, VAL18J, VAL29F, VAL29J, VAL61F
• F-K: ALA2F, ALA75K, GLN77K, LYS3F, PRO74K, THR76K
• F-L: ALA2F, THR76L
• F-M: ALA36F, ALA36M, ALA38M, ALA56F, ALA56M, ALA75M, ASN62F, ASN62M, ASP24F, GLN35F, GLN48F, GLN48M, GLN77F, GLN77M, GLU33F, GLU33M, GLU37M, GLU43M, GLU47M, GLU59F, GLU59M, GLU69M, GLU8M, GLY22F, GLY22M, GLY71F, ILE53F, LEU25F, LEU25M, LEU34F, LEU34M, LEU49F, LEU49M, LEU52F, LEU52M, LEU60F, LEU60M, LEU64F, LEU70F, LEU70M, LYS23M, LYS28F, LYS28M, LYS30F, LYS30M, LYS39M, LYS44M, LYS46F, LYS55F, LYS55M, MET26F, MET26M, PHE15F, PHE15M, PHE42F, PHE42M, PHE63F, PHE63M, PHE67F, PHE67M, PRO32F, PRO32M, PRO51F, PRO51M, PRO74F, PRO74M, SER31F, SER40M, SER45F, SER45M, SER65M, THR19M, THR58F, THR58M, THR76M, TYR14F, TYR14M, TYR21F, TYR21M, TYR41F, TYR41M, TYR66M, VAL11F, VAL11M, VAL18F, VAL18M, VAL29F, VAL29M, VAL61F, VAL68M, VAL7F
• F-N: ALA36F, ALA38F, ASP24N, GLN35F, GLN35N, GLN48F, GLN48N, GLU37F, GLU37N, GLU59F, GLU59N, LEU25F, LEU25N, LEU49N, LEU52F, LEU52N, LEU70F, LYS28F, LYS28N, LYS44F, LYS44N, LYS55F, LYS55N, PHE63F, PHE63N, PHE67N, PRO32N, SER45F, SER45N, THR17F, THR17N, TYR14F, TYR14N, TYR21F, TYR21N, TYR41F, TYR41N, TYR66F, VAL18N
• F-P: ALA2P, GLN77F, LYS3P, PRO5P
• G-H: ALA2G, ALA2H, ALA36G, ALA36H, ALA38G, ALA38H, ALA56G, ALA56H, ALA75G, ASN62G, ASN62H, ASP20H, ASP24H, CYS6G, CYS6H, GLN13G, GLN13H, GLN16G, GLN35H, GLN48G, GLN48H, GLN73H, GLU27G, GLU27H, GLU33G, GLU37G, GLU37H, GLU43G, GLU43H, GLU47G, GLU47H, GLU4G, GLU59G, GLU59H, GLU69G, GLU69H, GLU8G, GLU8H, GLY22H, GLY57H, GLY71G, ILE53G, LEU10G, LEU10H, LEU25H, LEU34G, LEU49G, LEU49H, LEU52G, LEU52H, LEU60G, LEU60H, LEU64G, LEU64H, LEU70G, LEU70H, LYS23G, LYS23H, LYS28H, LYS30G, LYS39G, LYS39H, LYS44G, LYS44H, LYS46G, LYS46H, LYS55G, LYS55H, MET26G, PHE15G, PHE42G, PHE63G, PHE63H, PHE67G, PHE67H, PRO32G, PRO32H, PRO51H, PRO5G, PRO5H, PRO74G, PRO74H, SER12G, SER31G, SER31H, SER40H, SER45G, SER45H, SER65G, SER65H, SER9G, SER9H, THR17G, THR17H, THR19G, THR50G, THR58H, THR72G, TYR14G, TYR14H, TYR21H, TYR41G, TYR41H, TYR66G, TYR66H, VAL11G, VAL11H, VAL29G, VAL61G, VAL68G, VAL7G, VAL7H
• G-M: ALA2G, ALA75M, CYS6G, GLN77M, GLU4G, GLU8G, LYS3G, THR76M, VAL7G
• G-N: ALA2G, ALA75N, CYS6G, GLN73N, GLN77N, GLU4G, GLY71N, LEU10G, LEU70N, LYS3G, PRO5G, PRO74N, THR72N, THR76N, VAL11G, VAL7G
• G-P: ALA2G, ALA2P, GLU4G, GLU4P, GLU59G, GLU8G, GLU8P, LEU52G, LEU52P, LEU60G, LEU60P, LYS3G, LYS3P, LYS55P, MET26G, MET26P, PHE15G, PHE15P, PHE63G, PHE63P, PHE67G, PHE67P, PRO5P, SER12G, SER12P, THR19G, TYR14G, TYR14P, TYR66G, VAL11G, VAL11P, VAL18G, VAL7G, VAL7P
• G-Q: ALA38G, ALA38Q, ALA56G, ALA56Q, ALA75Q, ASN62G, ASN62Q, GLN16G, GLN48G, GLN48Q, GLN73Q, GLU37G, GLU43Q, GLU47G, GLU47Q, GLU59G, GLU59Q, GLU69G, GLY22G, GLY22Q, GLY57Q, GLY71Q, ILE53G, ILE53Q, LEU10Q, LEU25G, LEU25Q, LEU49G, LEU49Q, LEU52G, LEU52Q, LEU60G, LEU60Q, LEU64Q, LEU70G, LEU70Q, LYS39Q, LYS3Q, LYS44G, LYS44Q, LYS46Q, LYS54G, LYS54Q, LYS55G, LYS55Q, MET26G, PHE15G, PHE15Q, PHE42G, PHE42Q, PHE63G, PHE67G, PHE67Q, PRO51G, PRO51Q, PRO74G, PRO74Q, SER40G, SER40Q, SER45G, SER45Q, THR17Q, THR19G, THR50G, THR50Q, THR58G, THR58Q, THR72Q, TYR14G, TYR14Q, TYR21G, TYR21Q, TYR41G, TYR41Q, TYR66G, VAL11G, VAL11Q, VAL18G, VAL18Q, VAL29G, VAL29Q, VAL61Q, VAL68Q, VAL7G, VAL7Q
• H-J: GLU33H, PRO74J
• H-L: ILE53H, LEU49H, LEU52H, LEU60H, LEU64H, LYS30L, LYS54H, MET26L, PHE15L, THR19L, THR50H, VAL68H
• H-M: ALA2H, ALA75M, CYS6H, GLN73M, GLN77M, GLU4H, LYS3H, PRO5H, PRO74M, THR76M, VAL7H
• H-P: ALA2H, ALA2P, ALA38H, ALA56H, ALA56P, ASN62P, GLN13H, GLN35P, GLN48H, GLN48P, GLU33H, GLU33P, GLU37H, GLU37P, GLU43P, GLU47P, GLU59H, GLU59P, GLY22H, GLY22P, GLY57H, GLY71H, ILE53H, LEU10H, LEU25H, LEU25P, LEU49H, LEU49P, LEU52H, LEU52P, LEU60H, LEU60P, LEU64H, LEU70H, LEU70P, LYS28H, LYS28P, LYS30H, LYS30P, LYS39H, LYS3H, LYS3P, LYS44P, LYS46H, LYS46P, LYS55H, LYS55P, MET26H, MET26P, PHE15H, PHE15P, PHE42H, PHE42P, PHE63H, PHE63P, PHE67H, PHE67P, PRO32H, PRO32P, PRO51P, PRO5H, PRO5P, SER12H, SER40H, SER45H, SER45P, SER65H, THR17H, THR17P, THR19H, THR19P, TYR14H, TYR14P, TYR21H, TYR21P, TYR41H, TYR41P, TYR66H, TYR66P, VAL11H, VAL11P, VAL18H, VAL18P, VAL29H, VAL29P, VAL68H, VAL7H, VAL7P
• H-Q: ALA38Q, GLN48H, GLN48Q, GLU37H, GLU37Q, GLU59H, GLU59Q, LEU25H, LEU25Q, LEU52H, LEU52Q, LEU70H, LEU70Q, LYS28H, LYS44H, LYS44Q, LYS55H, LYS55Q, PHE63H, PHE67H, PHE67Q, SER40H, SER45H, SER45Q, TYR21Q, TYR41H, TYR41Q
• I-J: ALA38I, ALA38J, ALA56I, ALA56J, ASN62J, ASP20J, ASP24J, CYS6I, CYS6J, GLN13I, GLN13J, GLN16I, GLN48I, GLN48J, GLU27I, GLU27J, GLU33I, GLU33J, GLU37J, GLU43I, GLU43J, GLU47I, GLU47J, GLU4I, GLU4J, GLU59I, GLU59J, GLU69I, GLU69J, GLU8I, GLU8J, GLY57J, GLY71I, ILE53I, LEU10I, LEU10J, LEU25J, LEU34I, LEU49I, LEU49J, LEU52I, LEU52J, LEU60I, LEU60J, LEU64I, LEU64J, LEU70I, LEU70J, LYS23I, LYS28J, LYS30I, LYS39I, LYS39J, LYS44I, LYS44J, LYS46I, LYS46J, LYS54I, LYS54J, LYS55I, LYS55J, MET26I, PHE15I, PHE42I, PHE42J, PHE63I, PHE63J, PHE67I, PHE67J, PRO32I, PRO32J, PRO51J, PRO5I, PRO5J, SER12I, SER31I, SER40J, SER45I, SER45J, SER65J, SER9I, SER9J, THR17J, THR19I, THR58J, THR72I, TYR14J, TYR21J, TYR41I, TYR41J, TYR66I, TYR66J, VAL11J, VAL18J, VAL29I, VAL61I, VAL68I, VAL7I, VAL7J
• I-K: ALA2K, ALA75I, GLN77I, LYS3K, THR76I
• I-M: GLU4I, THR17M
• I-W: ALA75I, GLN77I, THR17W, THR76I, TYR14W, TYR21W
• J-K: GLN77J, GLU4K, LYS3K
• J-L: ALA2L, GLN77J, GLU4L, LYS3L, PRO5L, THR76J, VAL7L
• J-M: ASN62M, ASP20J, ASP24J, ASP24M, CYS6J, GLN13J, GLN16J, GLN35J, GLN48M, GLU27J, GLU37M, GLU47M, GLU4J, GLU8J, GLY22M, LEU10J, LEU25M, LYS23J, LYS28M, LYS30J, LYS39J, LYS44M, MET26J, PRO32M, PRO5J, SER12J, SER31J, SER9J, THR17M, THR58M, TYR14M, TYR21M, VAL11J, VAL18M, VAL29M, VAL7J
• J-P: LEU25P, TYR21P, VAL68J
• K-L: ALA2L, ALA36L, ALA38L, ALA56K, ALA56L, ALA75K, ALA75L, ASN62K, ASN62L, ASP24L, CYS6K, CYS6L, GLN13L, GLN16K, GLN35L, GLN48K, GLN48L, GLN73K, GLN73L, GLN77K, GLN77L, GLU27K, GLU27L, GLU33K, GLU37L, GLU43K, GLU43L, GLU47K, GLU47L, GLU4K, GLU59K, GLU59L, GLU69K, GLU69L, GLU8K, GLY57K, GLY57L, GLY71K, GLY71L, ILE53K, LEU10K, LEU10L, LEU25L, LEU34K, LEU49K, LEU49L, LEU52K, LEU52L, LEU60K, LEU60L, LEU64K, LEU64L, LEU70K, LYS23K, LYS28L, LYS30K, LYS39K, LYS39L, LYS3L, LYS44K, LYS44L, LYS46K, LYS46L, LYS54K, LYS54L, LYS55K, LYS55L, MET26K, PHE15K, PHE42K, PHE63K, PHE63L, PHE67K, PHE67L, PRO32L, PRO51K, PRO51L, PRO5K, PRO5L, PRO74K, SER12K, SER31K, SER31L, SER40K, SER40L, SER45K, SER45L, SER65K, SER65L, SER9K, SER9L, THR17L, THR19K, THR50K, THR50L, THR58L, THR72K, THR72L, THR76K, THR76L, TYR14L, TYR21L, TYR41K, TYR41L, TYR66K, TYR66L, VAL11K, VAL29K, VAL61K, VAL68K, VAL7K, VAL7L
• K-M: ALA2M, CYS6M, GLN77K, GLU4M, GLU8M, LYS3M, PRO5M, THR76K, VAL7M
• K-W: ALA2K, ASP24K, ASP24W, GLN13K, GLU37W, GLU43W, LEU10K, LEU25W, LYS28W, LYS39W, LYS3K, SER40W, THR17K, THR17W, TYR14K, TYR14W, TYR21K, TYR21W, VAL11K, VAL18W
• K-6: GLN13K, GLU336, LEU10K, LEU346, LYS28K, LYS306, LYS466, MET266, SER9K, THR17K, VAL296
• L-M: ALA2M, GLN77L, GLU4M
• L-N: ALA2N, ALA75L, GLN77L, GLU4N, LYS3N, THR76L
• L-P: ALA36P, ASN62P, GLN16L, GLU43P, GLU47P, GLU4L, GLU8L, LYS23L, LYS30L, LYS3L, LYS44P, SER40P, THR58P, TYR66P, VAL7L
• M-N: ALA2M, ALA36N, ALA38M, ALA38N, ALA56M, ALA56N, ALA75M, ASN62N, ASP20N, ASP24N, CYS6M, CYS6N, GLN13M, GLN13N, GLN16M, GLN16N, GLN35N, GLN48M, GLN48N, GLN77M, GLN77N, GLU27N, GLU33M, GLU37N, GLU43M, GLU43N, GLU47M, GLU47N, GLU4M, GLU4N, GLU59M, GLU59N, GLU69M, GLU8M, GLU8N, GLY22N, GLY57N, GLY71M, GLY71N, ILE53M, LEU10M, LEU10N, LEU25N, LEU34M, LEU49M, LEU49N, LEU52M, LEU52N, LEU60M, LEU60N, LEU64M, LEU70M, LEU70N, LYS23M, LYS23N, LYS28N, LYS30M, LYS39M, LYS39N, LYS3N, LYS44M, LYS44N, LYS46M, LYS46N, LYS54N, LYS55M, LYS55N, MET26M, MET26N, PHE15M, PHE42M, PHE63M, PHE63N, PHE67M, PHE67N, PRO32N, PRO51N, PRO5M, PRO5N, PRO74M, SER12M, SER31M, SER31N, SER40M, SER40N, SER45M, SER45N, SER65M, SER9M, THR17N, THR19M, THR19N, THR58N, THR72M, THR76M, TYR14N, TYR21N, TYR41M, TYR41N, TYR66M, TYR66N, VAL11M, VAL18N, VAL29M, VAL61M, VAL68M, VAL7M, VAL7N
• M-P: ALA2P, ALA75M, GLN77M, GLU4P, LYS3P, PRO5P, THR76M, VAL7P
• N-P: GLN77N, GLU4P, GLU8P, LYS3P, PRO5P
• N-Q: ALA2Q, CYS6Q, GLN77N, GLU4Q, LYS3Q, PRO5Q, THR76N, VAL7Q
• P-Q: ALA2Q, ALA36Q, ALA38Q, ALA56P, ALA56Q, ALA75P, ASN62Q, ASP20Q, ASP24Q, CYS6P, CYS6Q, GLN13P, GLN13Q, GLN16P, GLN35Q, GLN48P, GLN48Q, GLN73Q, GLU27P, GLU27Q, GLU33P, GLU33Q, GLU37Q, GLU43P, GLU43Q, GLU47P, GLU47Q, GLU4P, GLU4Q, GLU59P, GLU59Q, GLU8P, GLU8Q, GLY22P, GLY57Q, GLY71P, ILE53P, ILE53Q, LEU10P, LEU10Q, LEU25Q, LEU34P, LEU49P, LEU49Q, LEU52P, LEU52Q, LEU60P, LEU60Q, LEU64P, LEU64Q, LEU70P, LEU70Q, LYS23P, LYS28Q, LYS30P, LYS39P, LYS39Q, LYS3P, LYS3Q, LYS44P, LYS44Q, LYS46P, LYS46Q, LYS54P, LYS55P, LYS55Q, MET26P, PHE15P, PHE42P, PHE63P, PHE67P, PHE67Q, PRO51P, PRO51Q, PRO5P, PRO5Q, PRO74P, SER12P, SER40Q, SER45P, SER45Q, SER65P, SER65Q, SER9P, SER9Q, THR17Q, THR19P, THR50P, THR50Q, THR58Q, THR72P, TYR14Q, TYR21Q, TYR41P, TYR41Q, TYR66P, TYR66Q, VAL11P, VAL29P, VAL61P, VAL68P, VAL7P, VAL7Q
• S-T: ALA36T, ALA38S, ALA38T, ALA56S, ALA56T, ALA75S, ASN62T, ASP24T, CYS6S, CYS6T, GLN13S, GLN13T, GLN16S, GLN35T, GLN48S, GLN48T, GLN73S, GLN73T, GLN77T, GLU27S, GLU27T, GLU33S, GLU37T, GLU43S, GLU43T, GLU47T, GLU4S, GLU4T, GLU59S, GLU59T, GLU69S, GLU69T, GLU8S, GLU8T, GLY22S, GLY71S, ILE53S, ILE53T, LEU10S, LEU10T, LEU25T, LEU34S, LEU49S, LEU49T, LEU52S, LEU52T, LEU60S, LEU60T, LEU64S, LEU70S, LEU70T, LYS23S, LYS28T, LYS30S, LYS39S, LYS39T, LYS44S, LYS44T, LYS46S, LYS46T, LYS54S, LYS54T, LYS55S, LYS55T, MET26S, PHE15S, PHE42S, PHE63S, PHE63T, PHE67S, PHE67T, PRO32T, PRO51T, PRO5S, PRO5T, PRO74S, PRO74T, SER12S, SER31S, SER31T, SER40S, SER40T, SER45S, SER45T, SER65T, SER9S, SER9T, THR17T, THR19S, THR50T, THR58T, THR72S, THR76S, TYR14T, TYR21T, TYR41S, TYR41T, TYR66S, TYR66T, VAL11S, VAL11T, VAL29S, VAL61S, VAL68S, VAL7S, VAL7T
• S-U: ALA2U, ALA75S, CYS6U, GLN13U, GLN73S, GLN77S, GLU4U, GLU69S, GLU8U, GLY71S, LEU10U, LEU70S, LYS3U, PRO5U, PRO74S, SER12U, SER9U, THR72S, THR76S, VAL11U, VAL68S, VAL7U
• S-V: ALA2V, ALA75S, CYS6V, GLN13V, GLN73S, GLU4V, GLU8V, GLY71S, LEU10V, LYS3V, PRO5V, PRO74S, SER9V, THR72S, THR76S, VAL68S, VAL7V
• S-1: ALA38S, GLN481, GLU331, GLU33S, GLU37S, GLU591, GLU59S, GLU81, GLU8S, LEU251, LEU49S, LEU521, LEU52S, LEU60S, LYS39S, LYS551, LYS55S, PHE15S, PHE421, PHE631, PHE63S, PHE67S, SER121, SER12S, TYR411, TYR41S, TYR661, VAL11S, VAL291, VAL71
• S-2: ALA382, ALA38S, ALA562, ASP20S, CYS62, GLN482, GLN48S, GLN77S, GLU332, GLU33S, GLU372, GLU37S, GLU42, GLU592, GLU59S, GLU8S, GLY22S, LEU102, LEU252, LEU25S, LEU492, LEU49S, LEU522, LEU52S, LEU602, LEU60S, LEU642, LEU702, LEU70S, LYS23S, LYS282, LYS28S, LYS30S, LYS392, LYS44S, LYS552, LYS55S, MET26S, PHE152, PHE15S, PHE422, PHE632, PHE63S, PHE672, PHE67S, PRO32S, PRO52, PRO742, SER40S, SER452, SER45S, THR19S, THR722, TYR142, TYR14S, TYR212, TYR21S, TYR412, TYR41S, TYR662, TYR66S, VAL112, VAL11S, VAL182, VAL18S, VAL292, VAL29S, VAL72
• S-3: GLU83, THR76S
• S-4: ALA24, ALA75S, CYS64, GLN77S, GLU44, LYS34, PRO54, THR76S, VAL74
• T-U: ALA75T, GLN73T, GLN77T, GLU4U, GLU69T, GLY71T, LEU70T, PRO74T
• T-V: ALA2V, ALA75T, CYS6V, GLN73T, GLN77T, GLU4V, GLU69T, GLU8V, GLY71T, LEU70T, LYS3V, PRO5V, PRO74T, SER9V, THR72T, THR76T, VAL68T
• T-1: ALA381, ALA38T, ALA561, ALA56T, ALA751, ALA75T, ASN621, CYS6T, GLN481, GLN48T, GLN731, GLN73T, GLN77T, GLU33T, GLU371, GLU37T, GLU41, GLU431, GLU43T, GLU471, GLU47T, GLU591, GLU59T, GLU691, GLU81, GLU8T, GLY221, GLY22T, GLY711, GLY71T, ILE531, ILE53T, LEU10T, LEU251, LEU25T, LEU491, LEU49T, LEU521, LEU52T, LEU601, LEU60T, LEU64T, LEU701, LEU70T, LYS231, LYS281, LYS28T, LYS30T, LYS39T, LYS441, LYS44T, LYS461, LYS46T, LYS541, LYS551, LYS55T, MET26T, PHE151, PHE15T, PHE421, PHE42T, PHE631, PHE63T, PHE671, PHE67T, PRO321, PRO32T, PRO51, PRO511, PRO51T, PRO741, PRO74T, SER121, SER401, SER451, SER45T, SER651, THR191, THR19T, THR501, THR50T, THR581, THR721, THR72T, THR761, THR76T, TYR141, TYR14T, TYR211, TYR21T, TYR411, TYR41T, TYR661, TYR66T, VAL11T, VAL181, VAL18T, VAL291, VAL29T, VAL611, VAL61T, VAL681, VAL68T, VAL71, VAL7T
• T-2: GLN482, GLN48T, GLN772, GLN77T, GLU592, GLU59T, LEU522, LEU60T, LEU702, LEU70T, LYS28T, LYS442, LYS552, LYS55T, PHE632, PHE63T, PHE672, PHE67T, THR762, TYR142, TYR212, TYR21T, TYR412, TYR41T, TYR662, TYR66T
• T-3: ALA75T, GLN77T, GLU43, LYS33, THR76T
• T-4: ALA24, GLN77T, GLU44, LYS34, PRO54
• U-V: ALA2V, ALA36V, ALA38U, ALA38V, ALA56U, ALA56V, ALA75U, ASN62V, ASP24V, CYS6U, CYS6V, GLN13V, GLN16U, GLN35V, GLN48U, GLN48V, GLN77V, GLU27U, GLU27V, GLU33U, GLU43U, GLU43V, GLU47U, GLU47V, GLU4U, GLU59U, GLU59V, GLU69V, GLU8U, GLU8V, GLY22U, GLY57U, GLY57V, GLY71U, ILE53U, LEU10V, LEU25V, LEU34U, LEU49U, LEU49V, LEU52U, LEU52V, LEU60U, LEU60V, LEU64U, LEU70U, LEU70V, LYS23U, LYS28V, LYS30U, LYS39U, LYS3V, LYS44U, LYS44V, LYS46U, LYS46V, LYS54U, LYS54V, LYS55U, LYS55V, MET26U, PHE15U, PHE42U, PHE63U, PHE63V, PHE67U, PRO32U, PRO51V, PRO5U, PRO5V, SER12U, SER31U, SER31V, SER40V, SER45U, SER45V, SER65V, SER9U, THR17V, THR19U, THR58V, TYR14V, TYR21V, TYR41U, TYR41V, TYR66U, TYR66V, VAL11U, VAL11V, VAL29U, VAL61U, VAL68U, VAL7U, VAL7V
• U-W: ALA2W, ALA75U, CYS6W, GLN73U, GLN77U, GLU4W, GLU8W, GLY71U, LEU10W, LEU70U, LYS3W, PRO5W, PRO74U, SER9W, THR72U, THR76U, VAL11W, VAL68U, VAL7W
• U-X: ALA2X, ALA75U, CYS6X, GLY71U, LEU70U, PRO5X, PRO74U, THR72U
• U-Z: GLU33Z, GLY57Z, ILE53Z, LEU10U, LEU25U, LYS3U, LYS46Z, LYS54Z, PHE42Z, THR50Z, TYR14U, TYR21U, VAL18U
• U-2: ALA2U, ALA752, GLN732, GLU4U, GLY712, LEU702, LYS3U, PRO742, THR722
• U-3: ALA563, CYS6U, GLN48U, GLU593, GLU59U, GLU83, GLU8U, LEU493, LEU523, LEU52U, LEU603, LEU60U, LEU643, LEU703, LEU70U, LYS553, LYS55U, PHE153, PHE42U, PHE633, PHE63U, PHE673, PHE67U, SER45U, TYR413, TYR663, TYR66U, VAL113, VAL11U, VAL73, VAL7U
• U-4: ALA2U, ALA364, ALA384, ALA38U, ALA564, ALA56U, ASN62U, ASP20U, CYS64, CYS6U, GLN134, GLN164, GLN16U, GLN354, GLN484, GLN48U, GLN734, GLN73U, GLN77U, GLU33U, GLU374, GLU37U, GLU434, GLU43U, GLU44, GLU474, GLU47U, GLU594, GLU59U, GLU694, GLU69U, GLU8U, GLY224, GLY22U, GLY714, GLY71U, ILE534, LEU104, LEU254, LEU25U, LEU344, LEU494, LEU49U, LEU524, LEU52U, LEU604, LEU60U, LEU704, LEU70U, LYS234, LYS23U, LYS284, LYS30U, LYS34, LYS394, LYS39U, LYS444, LYS44U, LYS464, LYS46U, LYS554, LYS55U, MET264, MET26U, PHE154, PHE15U, PHE424, PHE42U, PHE634, PHE63U, PHE674, PHE67U, PRO324, PRO32U, PRO514, PRO51U, PRO744, PRO74U, SER124, SER12U, SER404, SER40U, SER454, SER45U, SER654, SER65U, THR17U, THR194, THR19U, THR504, THR58U, THR724, THR76U, TYR144, TYR14U, TYR214, TYR21U, TYR414, TYR41U, TYR664, TYR66U, VAL114, VAL11U, VAL184, VAL18U, VAL294, VAL29U, VAL684, VAL68U, VAL74, VAL7U
• U-7: ALA2U, GLN357
• V-W: CYS6W, GLN77V, GLU4W, GLU69V, GLU8W, LEU70V, PRO5W, THR76V, VAL7W
• V-X: ALA2X, ALA75V, CYS6X, GLN13X, GLN73V, GLN77V, GLU4X, GLU69V, GLY71V, LEU10X, LEU70V, LYS3X, PHE67V, PRO5X, PRO74V, SER65V, SER9X, THR72V, THR76V, TYR66V, VAL11X, VAL68V, VAL7X
• V-1: ALA2V, ALA751, GLN731, GLN771, LYS3V, PRO741
• V-2: GLN772, LYS3V, THR762
• V-3: ALA23, ALA2V, ALA38V, ASP203, CYS63, CYS6V, GLN13V, GLN163, GLN16V, GLN353, GLN35V, GLN483, GLN48V, GLN733, GLU333, GLU33V, GLU43, GLU473, GLU47V, GLU4V, GLU593, GLU59V, GLU83, GLU8V, GLY223, GLY22V, GLY713, LEU103, LEU10V, LEU253, LEU25V, LEU343, LEU34V, LEU493, LEU49V, LEU523, LEU52V, LEU603, LEU60V, LEU64V, LEU703, LEU70V, LYS233, LYS283, LYS28V, LYS303, LYS30V, LYS33, LYS39V, LYS3V, LYS443, LYS44V, LYS463, LYS46V, LYS553, LYS55V, MET263, MET26V, PHE153, PHE15V, PHE42V, PHE633, PHE63V, PHE673, PHE67V, PRO323, PRO32V, PRO513, PRO53, PRO74V, SER123, SER12V, SER313, SER31V, SER40V, SER453, SER45V, SER93, THR173, THR17V, THR193, THR19V, THR583, THR72V, TYR143, TYR14V, TYR213, TYR21V, TYR413, TYR41V, TYR663, TYR66V, VAL113, VAL11V, VAL183, VAL18V, VAL293, VAL29V, VAL73, VAL7V
• V-4: ALA36V, ALA38V, ASP244, ASP24V, CYS64, CYS6V, GLN484, GLN48V, GLU374, GLY224, LEU104, LEU254, LEU25V, LYS284, LYS28V, LYS34, LYS3V, LYS444, LYS44V, LYS554, LYS55V, PRO54, SER40V, SER454, THR174, THR17V, TYR144, TYR14V, TYR214, TYR21V, TYR414, TYR41V, VAL184, VAL18V, VAL294, VAL29V, VAL74, VAL7V
• V-5: ALA75V, GLN73V, GLN77V, GLU85, LEU105, PHE155, PRO74V, THR76V, VAL115, VAL75
• V-6: GLN77V, THR76V, VAL76
• W-X: ALA2X, ALA36X, ALA38X, ALA56W, ALA56X, ALA75W, ASN62X, ASP20X, ASP24X, CYS6W, CYS6X, GLN13W, GLN13X, GLN16W, GLN35W, GLN35X, GLN48W, GLN48X, GLN77X, GLU27X, GLU33W, GLU37X, GLU43W, GLU43X, GLU47W, GLU47X, GLU4W, GLU4X, GLU59W, GLU59X, GLU69W, GLU8W, GLY22W, GLY57X, GLY71W, GLY71X, ILE53W, ILE53X, LEU10W, LEU10X, LEU25X, LEU34W, LEU49W, LEU49X, LEU52W, LEU52X, LEU60W, LEU60X, LEU64W, LEU64X, LEU70W, LEU70X, LYS23W, LYS23X, LYS28X, LYS30W, LYS39X, LYS3W, LYS3X, LYS44W, LYS44X, LYS46W, LYS46X, LYS54W, LYS55W, LYS55X, MET26W, MET26X, PHE15W, PHE42W, PHE42X, PHE63W, PHE63X, PHE67W, PHE67X, PRO32W, PRO32X, PRO51X, PRO5W, PRO5X, PRO74X, SER12W, SER31W, SER31X, SER40X, SER45W, SER45X, SER65W, SER65X, SER9W, SER9X, THR17X, THR19W, THR50W, THR50X, THR58X, THR72W, THR76W, TYR21X, TYR41W, TYR41X, TYR66W, TYR66X, VAL11W, VAL29W, VAL61W, VAL68W, VAL7W, VAL7X
• W-Y: ALA2Y, ALA75W, CYS6Y, GLN73W, GLN77W, GLU4Y, GLU69W, GLU8Y, GLY71W, LEU10Y, LEU70W, LYS3Y, PRO5Y, THR72W, THR76W, VAL68W, VAL7Y
• W-Z: ALA75W, CYS6Z, GLU4Z, GLY71W, LEU70W, LYS3Z, PRO5Z, THR72W, THR76W, VAL7Z
• W-4: ALA2W, ALA754, GLN734, GLN774, GLU4W, GLY714, LEU704, LYS3W, PRO744, THR724, THR764
• W-5: ALA385, ALA75W, GLN48W, GLN735, GLN775, GLU335, GLU33W, GLU375, GLU595, GLU59W, GLU85, GLY715, LEU345, LEU34W, LEU495, LEU525, LEU52W, LEU605, LEU60W, LEU705, LEU70W, LYS305, LYS30W, LYS555, LYS55W, MET265, MET26W, PHE425, PHE635, PHE63W, PHE675, PHE67W, PRO325, PRO5W, THR76W, TYR415, VAL29W
• W-6: ALA366, ALA386, ALA566, ALA56W, ALA756, ALA75W, ASN626, ASN62W, ASP206, ASP246, ASP24W, CYS66, CYS6W, GLN166, GLN16W, GLN356, GLN35W, GLN486, GLN48W, GLN736, GLN73W, GLN77W, GLU276, GLU27W, GLU336, GLU33W, GLU376, GLU37W, GLU436, GLU43W, GLU46, GLU476, GLU47W, GLU4W, GLU596, GLU59W, GLU696, GLU69W, GLU86, GLU8W, GLY226, GLY22W, GLY576, GLY57W, GLY716, ILE536, ILE53W, LEU106, LEU256, LEU25W, LEU346, LEU34W, LEU496, LEU49W, LEU526, LEU52W, LEU606, LEU60W, LEU646, LEU706, LEU70W, LYS236, LYS23W, LYS286, LYS28W, LYS306, LYS30W, LYS36, LYS396, LYS3W, LYS446, LYS44W, LYS466, LYS46W, LYS546, LYS54W, LYS556, LYS55W, MET266, MET26W, PHE156, PHE15W, PHE426, PHE42W, PHE636, PHE63W, PHE676, PHE67W, PRO326, PRO32W, PRO516, PRO51W, PRO56, PRO5W, PRO746, SER12W, SER316, SER31W, SER406, SER40W, SER456, SER45W, THR176, THR17W, THR196, THR19W, THR506, THR50W, THR586, THR58W, THR726, THR72W, THR76W, TYR146, TYR14W, TYR216, TYR21W, TYR416, TYR41W, TYR66W, VAL116, VAL11W, VAL186, VAL18W, VAL296, VAL29W, VAL616, VAL686, VAL76, VAL7W
• W-7: ALA27, ALA75W, GLN77W, GLU47, LYS37, PRO57, THR76W, VAL77
• W-8: GLN77W, LYS38
• X-Y: GLN77X, GLU4Y, GLU8Y, LEU70X
• X-Z: ALA75X, CYS6Z, GLN73X, GLN77X, GLU4Z, GLU69X, GLY71X, LEU10Z, LEU70X, LYS3Z, PRO5Z, PRO74X, SER12Z, SER9Z, THR72X, THR76X, VAL11Z, VAL7Z
• X-2: ALA362, ALA36X, ALA38X, ASP202, ASP242, GLN132, GLN162, GLN352, GLN35X, GLN48X, GLU272, GLU27X, GLU332, GLU33X, GLU42, GLU43X, GLU47X, GLY222, GLY22X, ILE53X, LEU25X, LEU342, LEU34X, LEU49X, LEU52X, LEU64X, LYS232, LYS23X, LYS302, LYS30X, LYS39X, LYS44X, LYS462, LYS46X, LYS54X, MET262, MET26X, PHE152, PHE15X, PHE422, PHE42X, PRO322, PRO32X, PRO51X, SER122, SER312, SER31X, SER45X, SER92, THR172, THR192, THR19X, THR50X, TYR14X, TYR212, TYR41X, VAL112, VAL182, VAL18X, VAL292, VAL29X, VAL61X, VAL72
• X-3: GLN733, GLY713, LYS3X
• X-5: ALA365, ALA36X, ALA385, ALA565, ALA56X, ALA755, ALA75X, ASN625, ASN62X, ASP24X, GLN35X, GLN485, GLN48X, GLN735, GLN775, GLN77X, GLU335, GLU33X, GLU375, GLU435, GLU475, GLU595, GLU59X, GLY225, GLY22X, GLY71X, ILE53X, LEU255, LEU25X, LEU345, LEU34X, LEU495, LEU49X, LEU525, LEU52X, LEU605, LEU60X, LEU645, LEU64X, LEU705, LEU70X, LYS28X, LYS305, LYS30X, LYS395, LYS445, LYS46X, LYS555, LYS55X, MET265, MET26X, PHE155, PHE15X, PHE425, PHE42X, PHE635, PHE63X, PHE675, PHE67X, PRO325, PRO32X, PRO515, PRO51X, PRO745, PRO74X, SER31X, SER405, SER455, SER45X, SER655, THR19X, THR585, THR58X, THR76X, TYR145, TYR14X, TYR215, TYR21X, TYR415, TYR41X, TYR665, VAL115, VAL11X, VAL185, VAL18X, VAL295, VAL29X, VAL61X, VAL685, VAL7X
• X-6: ALA36X, ALA38X, GLN35X, GLN486, GLN48X, GLU376, GLU37X, GLU596, GLU59X, LEU256, LEU25X, LEU526, LEU52X, LYS286, LYS28X, LYS446, LYS44X, LYS556, LYS55X, PHE636, PHE63X, PHE676, PHE67X, PRO326, SER40X, SER456, SER45X, TYR146, TYR14X, TYR21X, TYR416, TYR41X
• X-7: GLN77X, GLU47, LEU107, LYS37, PRO57, VAL117, VAL77
• Y-Z: ALA2Y, ALA36Y, ALA36Z, ALA38Y, ALA38Z, ALA56Y, ALA56Z, ALA75Y, ASN62Z, ASP20Z, ASP24Z, CYS6Y, CYS6Z, GLN13Y, GLN13Z, GLN16Y, GLN35Z, GLN48Y, GLN48Z, GLN73Z, GLU27Y, GLU27Z, GLU33Y, GLU37Y, GLU37Z, GLU43Y, GLU43Z, GLU47Y, GLU47Z, GLU4Y, GLU4Z, GLU59Y, GLU59Z, GLU69Y, GLU69Z, GLU8Y, GLY22Z, GLY71Y, ILE53Y, LEU10Y, LEU10Z, LEU25Z, LEU34Y, LEU49Y, LEU49Z, LEU52Y, LEU52Z, LEU60Y, LEU60Z, LEU64Y, LEU64Z, LEU70Y, LEU70Z, LYS23Y, LYS23Z, LYS28Z, LYS30Y, LYS39Y, LYS39Z, LYS3Z, LYS44Y, LYS44Z, LYS46Y, LYS46Z, LYS54Y, LYS55Y, LYS55Z, MET26Y, PHE15Y, PHE42Y, PHE63Y, PHE63Z, PHE67Y, PHE67Z, PRO32Y, PRO51Z, PRO5Y, PRO5Z, PRO74Y, PRO74Z, SER12Y, SER31Y, SER31Z, SER40Z, SER45Y, SER45Z, SER65Y, SER9Y, SER9Z, THR17Y, THR17Z, THR19Y, THR50Y, THR58Z, THR72Y, TYR14Y, TYR14Z, TYR21Z, TYR41Y, TYR41Z, TYR66Y, TYR66Z, VAL11Y, VAL11Z, VAL29Y, VAL68Y, VAL7Y, VAL7Z
• Y-5: ALA2Y, GLN775
• Y-6: ALA2Y, ALA756, GLN736, GLU4Y, GLY716, LEU706, LYS3Y, PRO5Y, PRO746, THR726
• Y-7: ALA27, ALA2Y, CYS67, GLU47, GLU4Y, GLU87, GLU8Y, LEU107, LYS37, LYS3Y, MET267, MET26Y, PHE157, PHE15Y, PHE63Y, PHE677, PHE67Y, PRO57, PRO5Y, SER127, SER12Y, THR19Y, TYR147, TYR14Y, TYR66Y, VAL117, VAL11Y, VAL77, VAL7Y
• Y-8: ALA388, ALA38Y, ALA568, ALA758, ASN62Y, ASP20Y, CYS68, GLN16Y, GLN488, GLN48Y, GLU33Y, GLU37Y, GLU438, GLU43Y, GLU478, GLU47Y, GLU598, GLU59Y, GLU69Y, GLY228, GLY22Y, GLY718, ILE538, ILE53Y, LEU108, LEU258, LEU25Y, LEU498, LEU49Y, LEU528, LEU52Y, LEU608, LEU60Y, LEU708, LEU70Y, LYS38, LYS398, LYS448, LYS44Y, LYS468, LYS548, LYS558, LYS55Y, MET26Y, PHE158, PHE15Y, PHE428, PHE42Y, PHE638, PHE63Y, PHE678, PHE67Y, PRO32Y, PRO51Y, PRO748, PRO74Y, SER40Y, SER458, SER45Y, THR178, THR17Y, THR19Y, THR508, THR58Y, THR728, TYR148, TYR14Y, TYR218, TYR21Y, TYR418, TYR41Y, TYR66Y, VAL118, VAL11Y, VAL188, VAL18Y, VAL298, VAL29Y, VAL688, VAL78, VAL7Y
• Z-2: LYS30Z, VAL682
• Z-4: ILE53Z, LEU49Z, LEU52Z, LEU60Z, LEU64Z, LYS304, LYS54Z, MET264, PHE154, THR194, THR50Z
• Z-5: ALA755, GLN735, GLN775, LYS3Z, PRO745, THR765
• Z-7: ALA36Z, ALA38Z, ALA56Z, CYS6Z, GLN357, GLN35Z, GLN487, GLN48Z, GLU337, GLU33Z, GLU37Z, GLU47, GLU597, GLY227, GLY22Z, ILE53Z, LEU107, LEU10Z, LEU257, LEU25Z, LEU347, LEU497, LEU49Z, LEU527, LEU52Z, LEU60Z, LEU64Z, LEU707, LEU70Z, LYS287, LYS28Z, LYS307, LYS30Z, LYS37, LYS39Z, LYS3Z, LYS447, LYS46Z, LYS557, MET267, MET26Z, PHE157, PHE15Z, PHE427, PHE42Z, PHE637, PHE63Z, PHE677, PHE67Z, PRO327, PRO32Z, PRO57, SER31Z, SER40Z, SER457, SER45Z, THR17Z, THR197, THR19Z, TYR147, TYR14Z, TYR217, TYR21Z, TYR417, TYR41Z, TYR667, VAL117, VAL11Z, VAL187, VAL18Z, VAL297, VAL29Z, VAL68Z, VAL77, VAL7Z
• Z-8: ALA388, GLN488, GLN48Z, GLU37Z, GLU598, GLU59Z, LEU258, LEU25Z, LEU528, LEU52Z, LEU708, LEU70Z, LYS288, LYS28Z, LYS448, LYS44Z, LYS558, LYS55Z, PHE638, PHE63Z, PHE678, PHE67Z, SER40Z, SER458, TYR218, TYR418, TYR41Z, TYR66Z
• 1-2: ALA381, ALA382, ALA561, ALA562, ALA751, ASN622, ASP202, ASP242, CYS61, CYS62, GLN131, GLN132, GLN161, GLN481, GLN482, GLN771, GLN772, GLU271, GLU272, GLU331, GLU332, GLU372, GLU41, GLU42, GLU431, GLU432, GLU471, GLU472, GLU591, GLU592, GLU692, GLU81, GLY572, ILE531, LEU102, LEU252, LEU341, LEU491, LEU492, LEU521, LEU522, LEU601, LEU602, LEU641, LYS231, LYS282, LYS301, LYS391, LYS392, LYS441, LYS442, LYS461, LYS462, LYS541, LYS542, LYS551, LYS552, MET261, PHE151, PHE421, PHE422, PHE631, PHE632, PHE671, PHE672, PRO321, PRO322, PRO51, PRO512, PRO52, SER121, SER311, SER402, SER451, SER452, SER652, SER91, THR172, THR191, THR582, THR761, THR762, TYR142, TYR212, TYR411, TYR412, TYR661, TYR662, VAL182, VAL291, VAL611, VAL681, VAL71, VAL72
• 1-3: ALA23, ALA751, GLN731, GLN771, GLU43, LYS33, PRO741, THR761
• 1-5: GLU41, THR175
• 2-3: ALA23, GLN772, GLU43, LYS33, THR762
• 2-4: ALA24, ALA752, GLN772, GLU44, LYS34, PRO54, PRO742, THR762
• 2-5: ASN625, ASP202, ASP205, ASP242, CYS62, GLN132, GLN162, GLN352, GLN485, GLU272, GLU375, GLU42, GLU475, LEU102, LEU255, LYS232, LYS285, LYS302, LYS392, LYS445, MET262, PRO325, PRO515, PRO52, SER122, SER312, SER92, THR175, THR585, TYR145, TYR215, VAL185, VAL295, VAL72
• 2-7: GLN357, LEU257, LYS287, PRO742, VAL682
• 3-4: ALA24, ALA364, ALA384, ALA563, ALA564, ALA753, ALA754, ASN623, ASN624, ASP244, CYS63, CYS64, GLN134, GLN163, GLN354, GLN483, GLN484, GLN773, GLN774, GLU273, GLU274, GLU333, GLU374, GLU43, GLU433, GLU434, GLU44, GLU473, GLU474, GLU593, GLU594, GLU694, GLU83, GLY573, GLY574, ILE533, LEU103, LEU104, LEU254, LEU343, LEU493, LEU494, LEU523, LEU524, LEU603, LEU604, LEU643, LEU703, LEU704, LYS233, LYS284, LYS303, LYS34, LYS393, LYS394, LYS443, LYS444, LYS463, LYS464, LYS543, LYS544, LYS553, LYS554, MET263, PHE153, PHE423, PHE633, PHE634, PHE673, PHE674, PRO324, PRO513, PRO514, PRO53, PRO54, SER123, SER313, SER314, SER403, SER404, SER453, SER454, SER653, SER93, SER94, THR174, THR193, THR503, THR504, THR584, THR763, THR764, TYR144, TYR214, TYR413, TYR414, TYR663, TYR664, VAL113, VAL114, VAL293, VAL613, VAL683, VAL73, VAL74
• 3-5: ALA25, ALA753, CYS65, GLN773, GLU45, LYS35, PRO55, PRO743, THR763, VAL75
• 3-6: ALA26, ALA753, GLN773, LYS36, PRO56, THR763
• 4-5: GLN774, GLU45
• 4-6: ALA26, ALA754, GLN734, GLN774, GLU46, LYS36, PRO56, PRO744, THR764
• 4-7: ASN627, GLN164, GLU44, LYS234, LYS304, SER407, THR587, TYR667
• 5-6: ALA26, ALA366, ALA385, ALA386, ALA565, ALA566, ASN625, ASN626, ASP206, ASP246, CYS65, CYS66, GLN135, GLN136, GLN356, GLN485, GLN486, GLU275, GLU276, GLU335, GLU376, GLU435, GLU436, GLU45, GLU46, GLU475, GLU476, GLU595, GLU596, GLU85, GLU86, GLY576, ILE535, LEU105, LEU106, LEU256, LEU345, LEU495, LEU496, LEU525, LEU526, LEU605, LEU606, LEU645, LEU705, LYS235, LYS286, LYS305, LYS36, LYS395, LYS396, LYS445, LYS446, LYS465, LYS466, LYS545, LYS555, LYS556, MET265, PHE155, PHE425, PHE635, PHE636, PHE675, PHE676, PRO326, PRO516, PRO55, PRO56, SER125, SER316, SER405, SER406, SER455, SER456, SER655, SER95, SER96, THR176, THR195, THR586, TYR146, TYR216, TYR415, TYR416, TYR665, TYR666, VAL115, VAL116, VAL295, VAL615, VAL685, VAL75, VAL76
• 5-7: ALA27, ALA755, GLN775, GLU47, LYS37, PRO57, THR765
• 6-7: ALA27, ALA756, CYS67, GLN736, GLN776, GLU47, GLU87, GLY716, LYS37, PRO57, PRO746, THR726, VAL77
• 6-8: ALA28, ALA756, CYS68, GLN776, GLU48, LYS38, PRO58
• 7-8: ALA368, ALA567, ALA757, ASN628, ASP208, ASP248, CYS67, CYS68, GLN137, GLN138, GLN167, GLN358, GLN488, GLN738, GLU277, GLU278, GLU337, GLU338, GLU378, GLU47, GLU478, GLU48, GLU597, GLU598, GLU697, GLU87, GLU88, GLY227, GLY717, ILE537, LEU107, LEU108, LEU258, LEU347, LEU497, LEU498, LEU527, LEU528, LEU607, LEU608, LEU647, LEU707, LEU708, LYS237, LYS288, LYS307, LYS38, LYS397, LYS448, LYS557, LYS558, MET267, PHE157, PHE427, PHE637, PHE638, PHE677, PHE678, PRO518, PRO57, PRO58, PRO747, PRO748, SER127, SER318, SER408, SER457, SER458, SER657, SER97, SER98, THR178, THR197, THR508, THR588, THR727, TYR148, TYR218, TYR417, TYR418, TYR667, TYR668, VAL117, VAL297, VAL617, VAL687, VAL77, VAL78