1BGY

cytochrome bc1 complex from bovine

• Total interactions analyzed: 231
• Total true interactions: 76
• Strongest Interaction:
  • Chains: Q-S
  • Int. Res.: 44
  • Norm. En. per Res.: -6.1594
• Hub Node: A(10)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-82.0293	-43.6255	-471.315	-596.9698	212	38	13	20157	3	55	51
A-C	-10.181	10.4191	-55.1881	-54.95	48	19	0	3989	1	17	21
A-D	-7.8263	3.8261	-21.8384	-25.8386	36	1	1	1401	1	11	11
A-E	-33.7247	2.5752	-212.538	-243.6875	108	24	3	10067	3	33	32
A-F	0.0	2.3572	-0.6839	1.6733	10	0	0	121	0	9	9
A-G	-85.9155	-50.3091	-240.402	-376.6266	70	27	1	9232	1	21	13
A-I	-29.3289	17.1573	-113.125	-125.2966	54	15	1	4628	4	19	16
A-J	0.0	-4.0566	-25.1162	-29.1728	26	2	0	1307	0	4	5
A-K	-2.9275	28.174	-2.3901	22.8565	26	22	0	1803	1	4	3
A-R	0.0	1.3166	-11.0076	-9.691	17	0	0	724	0	9	6
B-I	-44.6868	-42.4462	-238.66	-325.7929	157	50	10	14432	6	20	15
B-N	-60.0222	-133.3919	-105.402	-298.8161	88	23	0	6156	14	38	22
B-R	0.0	-10.7099	-79.6389	-90.3488	41	8	0	3460	1	25	22
C-D	-44.5558	-64.9712	-387.45	-496.977	147	42	9	16688	6	38	40
C-E	-15.1688	-4.5998	-114.902	-134.6707	52	19	1	5078	2	4	1
C-F	-40.2824	2.9941	-310.705	-347.9933	110	36	7	13864	2	38	31
C-G	0.0	-7.8245	-202.272	-210.0965	107	15	6	8986	0	17	14
C-J	0.0	0.0	-0.0065	-0.0065	2	0	0	6	0	0	0
C-K	0.0	0.0	-0.0007	-0.0007	2	0	0	2	0	0	0
C-O	0.0	42.379	-231.478	-189.099	120	26	11	10784	0	22	11
C-Q	-8.9493	-16.4044	-105.39	-130.7437	92	26	4	7491	2	11	13
C-S	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	0	0
C-W	0.0	0.0	-0.0075	-0.0075	2	0	0	7	0	0	0
D-E	-7.8687	-17.3422	-107.023	-132.2339	84	1	3	5333	1	12	20
D-F	-5.8214	-13.5529	-67.6363	-87.0106	39	8	1	3079	1	9	15
D-G	-71.6358	-1.5921	-205.386	-278.6139	62	44	7	8670	0	12	18
D-H	-21.6302	21.0213	-255.756	-256.3649	106	51	5	12490	1	17	32
D-J	-36.1786	-57.2175	-226.555	-319.9511	81	37	6	9620	3	48	40
D-P	0.0	0.0	-0.0443	-0.0443	10	0	0	38	0	0	2
D-Q	0.0	0.0	-0.58	-0.58	15	0	0	108	0	2	3
E-F	0.0	0.0	-0.6333	-0.6333	3	0	0	78	0	1	0
E-G	-38.8931	-73.1603	-165.82	-277.8734	47	20	3	5906	4	11	14
E-J	-31.2737	-17.7478	-156.282	-205.3035	58	25	16	6627	2	5	6
E-K	0.0	0.0	-7.2575	-7.2575	10	0	0	348	0	0	0
E-O	-2.6427	-2.3618	-62.3363	-67.3408	31	10	1	2658	0	3	3
F-G	-9.8137	-58.6604	-67.1018	-135.5759	53	12	2	3750	5	10	23
F-M	0.0	1.181	-7.6947	-6.5137	17	0	0	634	0	9	6
F-N	0.0	-12.3813	-74.2673	-86.6486	41	10	0	3328	0	23	22
F-W	0.0	0.0	-0.0064	-0.0064	2	0	0	7	0	0	2
G-H	-16.4011	-81.3805	-20.2202	-118.0018	28	3	0	1110	4	23	14
G-J	0.0	0.0	-0.1723	-0.1723	3	0	0	28	0	0	0
G-O	0.0	0.0	-0.0156	-0.0156	2	0	0	11	0	0	0
G-S	0.0	0.0	-0.0009	-0.0009	2	0	0	3	0	0	0
H-Q	0.0	0.0	-0.0338	-0.0338	2	0	0	3	0	0	1
J-K	0.0	0.0	-87.0294	-87.0294	36	6	7	3922	0	0	1
K-O	0.0	0.0	-0.0139	-0.0139	2	0	0	10	0	0	0
K-R	0.0	0.0	-0.0067	-0.0067	2	0	0	7	0	0	2
M-N	-110.5069	-49.5033	-472.008	-632.0182	214	52	12	20197	3	55	51
M-O	-8.9297	9.6397	-71.0199	-70.3098	50	16	0	3983	1	17	20
M-P	0.0	3.6658	-21.6713	-18.0055	36	0	1	1381	1	11	11
M-Q	-20.8897	5.9313	-216.115	-231.0734	106	26	3	10486	3	33	32
M-R	0.0	2.3574	-0.5018	1.8555	10	0	0	116	0	9	9
M-S	-97.491	-50.78	-231.445	-379.716	72	28	2	9216	1	21	13
M-U	-26.4694	17.1797	-122.672	-131.9617	53	16	1	4697	4	19	16
M-V	-13.0839	-4.1134	-24.7685	-41.9657	26	5	0	1354	0	4	5
M-W	0.0	27.6323	-13.6844	13.948	24	19	0	1880	1	4	3
N-U	-40.5405	-39.869	-229.862	-310.2715	159	53	10	14593	6	19	14
O-P	-55.1145	-68.7408	-381.118	-504.9734	148	48	10	16715	6	38	40
O-Q	-18.3755	-4.5347	-118.492	-141.4022	51	15	1	5055	2	4	1
O-R	-40.887	3.9045	-310.07	-347.0526	112	29	9	14067	2	38	31
O-S	-4.9847	-8.051	-223.641	-236.6767	109	7	6	9060	0	17	14
O-V	0.0	0.0	-0.0063	-0.0063	2	0	0	6	0	0	0
O-W	0.0	0.0	-0.0007	-0.0007	2	0	0	2	0	0	0
P-Q	0.0	-16.8703	-100.363	-117.2333	98	1	3	5533	1	15	23
P-R	-2.1163	-13.3269	-69.0023	-84.4455	38	9	1	3144	1	9	16
P-S	-83.3229	-2.0122	-208.982	-294.3171	62	38	5	8565	0	12	18
P-T	-24.7869	22.0472	-242.215	-244.9547	106	62	5	12493	0	17	30
P-V	-54.9333	-55.2792	-197.929	-308.1415	80	52	6	9698	4	48	41
Q-R	0.0	0.0	-0.4763	-0.4763	3	0	0	67	0	1	0
Q-S	-37.1226	-71.7438	-162.149	-271.0153	44	16	3	5826	4	11	14
Q-V	-14.1723	-10.28	-167.849	-192.3013	61	18	16	6793	1	6	6
Q-W	0.0	0.0	-6.9097	-6.9097	10	0	0	347	0	0	0
R-S	-20.9529	-57.8616	-74.1959	-153.0104	56	18	2	3971	6	10	22
S-T	-17.1632	-82.6735	-15.3938	-115.2305	28	5	0	1115	4	23	14
S-V	0.0	0.0	-0.1679	-0.1679	2	0	0	27	0	0	0
V-W	0.0	0.0	-88.9451	-88.9451	36	7	7	3810	0	0	1

Interface residues

• A-B: ALA101A, ALA149B, ALA151B, ALA275A, ALA281B, ALA288A, ALA291B, ALA295A, ALA2A, ALA359B, ALA360B, ALA364A, ALA366B, ALA393A, ALA42B, ALA44B, ALA5A, ALA63A, ALA72B, ALA74A, ALA7A, ALA84A, ALA88A, ALA91B, ALA96A, ARG113B, ARG287B, ARG356A, ARG362A, ARG46B, ARG70B, ARG87B, ASN290B, ASN359A, ASN362B, ASN363A, ASN40B, ASN73A, ASN87A, ASP105A, ASP114B, ASP115B, ASP147B, ASP281A, ASP356B, ASP370A, CYS111B, CYS282A, CYS35A, GLN136A, GLN143B, GLN153B, GLN297B, GLN29A, GLN305A, GLN329B, GLN32A, GLN358B, GLN6A, GLN9A, GLU110B, GLU130A, GLU136B, GLU137A, GLU140A, GLU168A, GLU28A, GLU353A, GLU373B, GLU376B, GLU396A, GLU39B, GLU60A, GLU76A, GLU78A, GLU80A, GLU90B, GLY201A, GLY210B, GLY282B, GLY285A, GLY286A, GLY287A, GLY288B, GLY357A, GLY367B, GLY371A, GLY377B, GLY72A, GLY83A, GLY88B, GLY93B, GLY94B, HIS277B, HIS284B, HIS289A, HIS368A, HIS61A, HIS85A, ILE116A, ILE134A, ILE146B, ILE297A, ILE399A, ILE85B, ILE89B, ILE99A, LEU102A, LEU112B, LEU119B, LEU140B, LEU209B, LEU250A, LEU252B, LEU290A, LEU355A, LEU360A, LEU361A, LEU364B, LEU365A, LEU369A, LEU369B, LEU392A, LEU399B, LEU62A, LEU71B, LEU75A, LEU75B, LEU86A, LEU8A, LEU96B, LYS100A, LYS104A, LYS148B, LYS286B, LYS302A, LYS358A, LYS361B, LYS363B, LYS365B, LYS65A, LYS77A, LYS84B, LYS95B, MET370B, MET82A, PHE378B, PHE58A, PHE64A, PHE83B, PRO12A, PRO214B, PRO283B, PRO293A, PRO306B, PRO33A, PRO355B, PRO374A, PRO395B, PRO43B, SER103A, SER10A, SER212B, SER289B, SER291A, SER292A, SER293B, SER296A, SER30A, SER367A, SER371B, SER374B, SER375B, SER396B, SER45B, SER73B, SER74B, SER81A, SER81B, SER82B, SER90A, THR1A, THR283A, THR292B, THR34A, THR36A, THR372A, THR373A, THR3A, THR76B, THR86B, TYR280A, TYR284A, TYR368B, TYR41B, TYR4A, TYR57A, TYR89A, TYR97A, TYR98A, VAL11A, VAL133A, VAL150B, VAL167A, VAL211B, VAL285B, VAL366A, VAL372B, VAL375A, VAL59A, VAL79A, VAL92B
• A-C: ARG244A, ARG436A, ARG438A, ARG445A, ARG5C, ASN16C, ASN301A, ASN3C, ASN435A, ASP20C, ASP214C, ASP216C, ASP332A, ASP333A, ASP433A, GLU429A, HIS221C, ILE19C, ILE218C, ILE297A, ILE437A, ILE4C, LEU21C, LEU303A, LEU431A, LEU444A, LYS12C, LYS217C, LYS302A, LYS6C, MET1C, PHE18C, PHE220C, PHE336A, PHE442A, PHE446A, PRO219C, PRO222C, PRO432A, SER439A, THR225C, THR2C, THR300A, TRP443A, TYR223C, TYR434A, VAL215C, VAL337A
• A-D: ALA236D, ARG224D, ARG233D, ARG238D, ARG244A, ARG436A, ARG438A, ASN435A, ASP433A, CYS242A, CYS419A, GLN240A, GLU245A, GLY238A, HIS225D, HIS243A, ILE241A, ILE437A, LEU230D, LEU235D, LEU431A, LYS226D, LYS234D, PHE442A, PRO239D, PRO240D, PRO432A, SER171A, SER228D, SER239A, SER439A, TRP227D, TYR152A, TYR237D, TYR434A, VAL229D
• A-E: ALA155A, ALA157A, ALA164A, ARG146A, ARG14E, ARG15E, ARG235A, ARG32E, ARG438A, ARG92A, ASN141A, ASN151A, ASN173A, ASN53A, ASP142A, ASP147A, ASP20E, ASP316A, ASP417A, ASP4E, ASP9E, CYS234A, CYS419A, GLN139A, GLN159A, GLN165A, GLN240A, GLN418A, GLU137A, GLU140A, GLU168A, GLU172A, GLU17E, GLU258A, GLU27E, GLU30E, GLY160A, GLY169A, GLY238A, GLY259A, GLY261A, GLY34E, HIS154A, HIS243A, HIS264A, HIS2E, ILE134A, ILE241A, ILE5E, LEU135A, LEU138A, LEU153A, LEU19E, LEU231A, LYS23E, LYS26E, LYS33E, LYS413A, LYS6E, MET145A, MET441A, PHE10E, PHE150A, PHE158A, PHE236A, PHE415A, PHE425A, PHE442A, PRO162A, PRO170A, PRO229A, PRO233A, PRO260A, PRO8E, SER11E, SER144A, SER166A, SER171A, SER1E, SER21E, SER232A, SER239A, SER24E, SER25E, SER28E, SER29E, SER36E, SER412A, SER439A, THR143A, THR156A, THR161A, THR22E, THR237A, THR317A, THR3E, TYR152A, TYR37E, TYR414A, TYR416A, TYR434A, VAL148A, VAL149A, VAL167A, VAL174A, VAL18E, VAL257A, VAL7E
• A-F: ARG244A, ASP246A, ASP56F, CYS242A, GLU245A, GLU429A, GLU52F, LYS63F, TYR55F, VAL59F
• A-G: ALA155A, ALA157A, ALA421A, ARG11G, ARG235A, ARG244A, ARG2G, ARG436A, ARG438A, ARG9G, ASN435A, ASP246A, ASP332A, ASP417A, ASP433A, CYS242A, CYS419A, GLN159A, GLN23G, GLN240A, GLN3G, GLN418A, GLN430A, GLU22G, GLU245A, GLU258A, GLU429A, GLY238A, GLY247A, GLY424A, GLY426A, GLY5G, HIS12G, HIS243A, HIS328A, HIS6G, ILE14G, ILE241A, ILE331A, ILE428A, LEU18G, LEU248A, LEU431A, LEU7G, MET329A, PHE21G, PHE236A, PHE425A, PHE442A, PHE4G, PRO20G, PRO249A, PRO420A, PRO427A, PRO432A, SER17G, SER19G, SER239A, SER330A, SER439A, THR156A, THR15G, THR237A, THR8G, TYR152A, TYR16G, TYR434A, VAL10G, VAL13G, VAL422A
• A-I: ALA74I, ARG131A, ARG47I, ARG52I, ASN141A, ASN71I, ASP132A, ASP142A, ASP147A, ASP281A, CYS282A, CYS51I, GLN126A, GLN136A, GLN139A, GLU130A, GLU137A, GLU140A, GLU53I, GLU60A, GLY278A, GLY285A, GLY286A, GLY287A, HIS279A, HIS289A, HIS61A, ILE134A, LEU248A, LEU290A, LEU360A, LEU50I, LEU62A, LEU70I, LYS129A, LYS46I, LYS65A, MET145A, PHE64A, PRO249A, PRO73I, SER144A, SER48I, SER54I, SER69I, SER75I, THR143A, THR283A, TYR280A, TYR284A, VAL133A, VAL49I, VAL68I, VAL72I
• A-J: ALA21J, ARG15J, ARG16J, ARG408A, ARG438A, ARG445A, ASP417A, CYS346A, CYS411A, GLN418A, GLU409A, LEU444A, LYS413A, PHE14J, PHE20J, PHE415A, PHE442A, SER18J, SER412A, THR17J, THR347A, TRP443A, TYR10J, TYR414A, TYR416A, VAL410A
• A-K: ALA349A, ALA404A, ARG15K, ARG344A, ARG405A, ARG408A, ASN16K, ASP403A, CYS346A, GLU351A, GLU409A, LEU345A, LEU444A, MET343A, PRO19K, SER348A, SER352A, SER412A, THR20K, THR347A, THR350A, TRP17K, TRP24K, TRP443A, VAL354A, VAL406A
• A-R: ALA108R, ALA288A, ARG104R, ARG356A, ARG408A, ARG49R, GLU100R, GLU351A, GLU353A, HIS289A, LEU355A, LYS109R, LYS110R, SER291A, SER352A, THR350A, TRP107R
• B-I: ALA106B, ALA151B, ALA157B, ALA281B, ALA311B, ALA314B, ALA386B, ALA388B, ALA389B, ALA59I, ALA60I, ALA66I, ALA72B, ALA74I, ARG102B, ARG287B, ARG46B, ARG47I, ARG52I, ARG56I, ARG62I, ARG70B, ARG77I, ARG87B, ASN104B, ASN154B, ASN290B, ASN313B, ASN71I, ASP147B, ASP250B, ASP308B, ASP380B, CYS51I, GLN143B, GLN153B, GLN156B, GLN276B, GLN305B, GLN329B, GLN385B, GLN401B, GLN58I, GLU103B, GLU110B, GLU161B, GLU376B, GLU381B, GLU53I, GLU90B, GLY265B, GLY280B, GLY282B, GLY288B, GLY320B, GLY323B, GLY377B, GLY383B, GLY390B, GLY57I, GLY61I, GLY88B, GLY93B, GLY94B, HIS158B, HIS164B, HIS254B, HIS277B, HIS284B, HIS67B, ILE160B, ILE264B, ILE327B, ILE402B, ILE85B, ILE89B, LEU140B, LEU152B, LEU163B, LEU172B, LEU176B, LEU252B, LEU321B, LEU364B, LEU387B, LEU50I, LEU55I, LEU64I, LEU68B, LEU69B, LEU70I, LEU71B, LEU96B, LYS148B, LYS286B, LYS46I, LYS95B, MET105B, PHE307B, PHE312B, PHE322B, PHE324B, PHE50B, PRO155B, PRO283B, PRO306B, PRO63I, PRO73I, SER100B, SER175B, SER251B, SER273B, SER289B, SER310B, SER315B, SER371B, SER384B, SER391B, SER48I, SER54I, SER67I, SER69I, SER73B, SER74B, SER75I, SER82B, SER97B, THR101B, THR108B, THR326B, THR393B, THR86B, THR99B, TYR107B, TYR168B, TYR177B, TYR296B, TYR316B, TYR325B, TYR368B, TYR392B, TYR78I, VAL109B, VAL150B, VAL159B, VAL258B, VAL285B, VAL309B, VAL372B, VAL382B, VAL398B, VAL49I, VAL65I, VAL68I, VAL72I, VAL76I, VAL98B
• B-N: ALA165B, ALA165N, ALA166B, ALA166N, ALA173B, ALA173N, ALA330B, ALA330N, ARG169B, ARG169N, ARG182B, ARG182N, ARG245B, ARG245N, ARG421B, ARG421N, ASN170B, ASN170N, ASN174B, ASN174N, ASN248B, ASN248N, ASN429B, ASN429N, ASN59B, ASN59N, ASN61B, ASN61N, ASN62B, ASN62N, ASP250B, ASP250N, ASP437B, ASP437N, GLN247B, GLN247N, GLU243B, GLU243N, GLU246B, GLU246N, GLU438B, GLU438N, GLY241B, GLY241N, GLY242B, GLY242N, GLY249B, GLY249N, GLY428B, GLY428N, GLY431B, GLY431N, HIS240B, HIS240N, HIS432B, HIS432N, ILE244B, ILE244N, ILE436B, ILE436N, LEU430B, LEU430N, LEU63B, LEU63N, LYS185B, LYS185N, LYS238B, LYS238N, LYS338B, LYS338N, PHE435B, PHE435N, PRO179B, PRO179N, PRO434B, PRO434N, SER251B, SER251N, SER60B, SER60N, THR433B, THR433N, TYR168B, TYR168N, TYR181B, TYR181N, TYR239B, TYR239N
• B-R: ALA108R, ALA80B, ALA91B, ARG104R, ARG133B, ARG134B, ARG48R, ARG49R, ARG87B, ARG99R, ASN53R, GLU100R, GLU103R, GLU105R, GLU106R, GLU131B, GLU136B, GLU45R, GLU52R, GLU90B, GLU96R, GLY88B, ILE85B, ILE89B, LEU50R, LEU54R, LYS84B, PHE122B, PHE83B, PRO51R, PRO92R, SER81B, SER82B, THR76B, THR86B, TRP107R, TRP135B, TYR55R, TYR93R, VAL92B, VAL97R
• C-D: ALA119D, ALA193D, ALA194D, ALA221D, ALA232C, ALA238C, ALA23C, ALA246C, ALA47D, ARG102D, ARG118D, ARG120D, ARG191D, ARG201D, ARG203D, ARG224D, ARG233D, ARG49D, ARG71C, ARG80C, ASN255C, ASN260C, ASN263C, ASN26C, ASN32C, ASP112D, ASP199D, ASP216C, ASP228C, ASP248C, ASP252C, ASP254C, ASP44D, ASP72C, CYS70C, GLN137C, GLU195D, GLU197D, GLU344C, GLY122D, GLY123D, GLY16D, GLY205D, GLY213D, GLY231C, HIS121D, HIS198D, HIS200D, HIS221C, HIS225D, HIS267C, HIS68C, ILE116D, ILE218C, ILE226C, ILE229C, ILE236C, ILE27C, ILE78C, ILE79C, LEU109D, LEU17D, LEU18D, LEU190D, LEU206D, LEU209D, LEU210D, LEU214D, LEU215D, LEU216D, LEU218D, LEU230C, LEU230D, LEU233C, LEU234C, LEU235C, LEU235D, LEU237C, LEU239C, LEU241C, LEU242C, LEU244C, LEU249C, LEU262C, LYS202D, LYS207D, LYS217C, LYS223D, LYS226D, LYS227C, LYS231D, LYS269C, MET204D, MET208D, MET211D, MET212D, MET222D, MET240C, MET43D, MET82C, PHE189D, PHE220C, PHE245C, PHE63C, PRO111D, PRO154D, PRO196D, PRO217D, PRO219C, PRO222C, PRO247C, PRO24C, PRO253C, PRO258C, PRO266C, SER114D, SER19D, SER1D, SER228D, SER25C, SER29C, SER64C, SER65C, SER88D, THR225C, THR257C, THR60C, THR61C, THR67C, TRP192D, TRP227D, TRP77C, TYR115D, TYR220D, TYR223C, TYR224C, TYR256C, TYR45D, TYR75C, TYR81C, TYR90D, VAL117D, VAL219D, VAL229D, VAL243C, VAL46D, VAL73C
• C-E: ALA50E, ALA64E, ALA66E, ALA70E, ARG71C, ARG80C, ASN53E, ASN74C, ASP67E, ASP72C, GLN44C, GLN57E, GLY48C, GLY76C, HIS54C, HIS68C, HIS83C, ILE226C, ILE229C, ILE236C, ILE42C, ILE45C, ILE69C, ILE78C, ILE79C, LEU233C, LEU244C, LEU43C, LEU46C, LEU51C, LEU69E, MET240C, MET53C, MET62E, MET82C, PHE50C, PHE58E, SER56E, SER60E, SER61E, SER63E, SER65E, THR43E, THR47C, TRP77C, TYR75C, VAL47E, VAL54E, VAL55E, VAL59E, VAL68E, VAL73C
• C-F: ALA23F, ALA24F, ALA369C, ALA65F, ARG17F, ARG313C, ARG318C, ARG33F, ARG48F, ARG58F, ARG61F, ARG64F, ARG71F, ASN206C, ASN207C, ASN22F, ASN26C, ASN27F, ASN374C, ASN40F, ASP214C, ASP216C, ASP34F, ASP35F, ASP67F, ASP86F, GLN312C, GLN322C, GLN72F, GLU14F, GLU373C, GLU39F, GLU91F, GLY105C, GLY15F, GLY210C, GLY25F, GLY370C, HIS308C, HIS38F, ILE16F, ILE211C, ILE218C, ILE27C, ILE372C, ILE37F, ILE47F, ILE62F, ILE98F, LEU13F, LEU29F, LEU31F, LEU320C, LEU376C, LEU377C, LEU66F, LEU68F, LEU90F, LEU94F, LYS18F, LYS217C, LYS227C, LYS28F, LYS311C, LYS375C, LYS378C, LYS44F, LYS63F, LYS87F, LYS95F, MET315C, MET316C, MET32F, MET70F, PHE109C, PHE26F, PHE317C, PHE60F, PRO208C, PRO24C, PRO319C, PRO92F, SER106C, SER212C, SER213C, SER25C, SER28C, SER29C, SER310C, SER314C, SER321C, SER69F, SER88F, THR108C, THR209C, THR36F, THR371C, TRP19F, TRP30C, TRP379C, TYR104C, TYR107C, TYR20F, TYR21F, TYR224C, TYR55F, TYR83F, VAL215C, VAL43F, VAL59F
• C-G: ALA17C, ALA23C, ALA327C, ALA330C, ALA354C, ALA43G, ALA49G, ALA54G, ARG2G, ARG318C, ARG40G, ARG47G, ARG9G, ASP20C, ASP214C, ASP216C, ASP331C, CYS323C, CYS44G, GLN322C, GLN341C, GLN3G, GLN64G, GLU202C, GLU344C, GLU65G, GLU67G, GLY1G, GLY204C, GLY5G, GLY62G, HIS201C, HIS221C, HIS345C, HIS6G, ILE19C, ILE218C, ILE338C, ILE348C, ILE350C, ILE45G, LEU200C, LEU21C, LEU320C, LEU324C, LEU328C, LEU332C, LEU333C, LEU335C, LEU353C, LEU357C, LEU361C, LEU46G, LEU57G, LEU7G, LYS217C, LYS68G, LYS70G, MET315C, MET316C, PHE220C, PHE317C, PHE325C, PHE4G, PHE52G, PHE55G, PHE66G, PRO20G, PRO219C, PRO222C, PRO22C, PRO24C, PRO319C, PRO342C, PRO346C, PRO50G, PRO51G, SER17G, SER212C, SER213C, SER28C, SER29C, SER321C, SER69G, THR203C, THR334C, THR336C, THR349C, THR60G, THR63G, THR8G, TRP326C, TRP337C, TRP61G, TYR103C, TYR223C, TYR347C, TYR56G, TYR59G, VAL10G, VAL13G, VAL215C, VAL329C, VAL343C, VAL48G, VAL53G, VAL58G
• C-J: PHE245C, TYR43J
• C-K: ARG5C, TRP17K
• C-O: ALA173C, ALA173O, ALA180C, ALA180O, ALA191C, ALA191O, ALA52C, ALA52O, ALA62C, ALA62O, ARG177C, ARG177O, ASN74C, ASN74O, ASP58C, ASP58O, GLU111C, GLU111O, GLU202C, GLU202O, GLY166C, GLY166O, GLY48C, GLY48O, HIS182C, HIS182O, HIS196C, HIS196O, HIS201C, HIS201O, HIS54C, HIS54O, HIS68C, HIS68O, HIS8C, HIS8O, ILE115C, ILE115O, ILE13C, ILE13O, ILE184C, ILE184O, ILE188C, ILE188O, ILE192C, ILE45C, ILE45O, ILE69C, ILE69O, LEU10C, LEU10O, LEU175C, LEU185C, LEU185O, LEU198C, LEU198O, LEU46C, LEU46O, LEU49C, LEU49O, LEU51C, LEU51O, LYS12C, LYS12O, LYS172C, LYS172O, MET11C, MET11O, MET190C, MET190O, MET194C, MET194O, MET53C, MET53O, PHE178C, PHE178O, PHE179C, PHE179O, PHE181C, PHE181O, PHE183C, PHE183O, PHE187C, PHE187O, PHE199C, PHE199O, PHE50C, PHE50O, PRO186C, PRO186O, PRO9C, PRO9O, SER57C, SER57O, SER65C, SER65O, SER7C, SER7O, THR174C, THR174O, THR176C, THR176O, THR56C, THR56O, THR59C, THR59O, THR60C, THR60O, THR61C, THR61O, TRP163C, TRP163O, TYR55C, TYR55O, VAL14C, VAL14O, VAL195C, VAL195O, VAL73C, VAL73O
• C-Q: ALA173C, ALA64Q, ALA70Q, ALA88Q, ARG177C, ARG282C, ARG92Q, ASN148C, ASN159C, ASN260C, ASN263C, ASP171C, ASP67Q, CYS144Q, CYS158Q, CYS160Q, GLN137C, GLN341C, GLU162C, GLU344C, GLY137Q, GLY143Q, GLY162Q, GLY166C, GLY167C, GLY93Q, HIS141Q, HIS161Q, HIS267C, HIS345C, ILE147Q, ILE164C, ILE268C, ILE348C, LEU142Q, LEU149C, LEU160C, LEU262C, LEU281C, LEU69Q, LEU96Q, LYS172C, LYS287C, LYS73Q, LYS90Q, LYS94Q, MET62Q, MET71Q, MET87Q, PHE140C, PHE168C, PHE181C, PHE58Q, PHE89Q, PHE97Q, PRO146Q, PRO159Q, PRO175Q, PRO177Q, PRO261C, PRO265C, PRO266C, PRO285C, PRO342C, PRO95Q, SER169C, SER60Q, SER61Q, SER63Q, SER65Q, SER72Q, THR140Q, THR144C, THR174C, THR264C, THR59C, TRP135C, TRP141C, TRP163C, TRP165C, TRP91Q, TYR157Q, TYR278C, VAL138Q, VAL145C, VAL145Q, VAL161C, VAL170C, VAL343C, VAL55Q, VAL59Q, VAL68Q
• C-S: GLY1S, LEU10C
• C-W: ILE156C, THR36W
• D-E: ALA221D, ALA236D, ALA41E, ALA47D, ALA48E, ALA50E, ALA51E, ALA66E, ALA70E, ARG14E, ARG15E, ARG201D, ARG224D, ARG233D, ARG238D, ARG32E, ARG49D, ASN53E, ASP12E, ASP4E, ASP67E, ASP9E, GLN57E, GLU58D, GLU75E, GLY46E, GLY85D, HIS200D, HIS225D, HIS2E, ILE5E, ILE74E, LEU210D, LEU214D, LEU215D, LEU216D, LEU218D, LEU235D, LEU38E, LEU87D, LYS207D, LYS223D, LYS226D, LYS231D, LYS234D, LYS33E, LYS62D, LYS6E, LYS73E, LYS86D, MET204D, MET208D, MET211D, MET212D, MET222D, MET71E, PHE10E, PHE35E, PRO217D, PRO239D, PRO240D, PRO8E, SER1E, SER228D, SER232D, SER36E, SER88D, THR3E, THR40E, THR42E, THR43E, THR44E, TYR13E, TYR220D, TYR37E, TYR49E, TYR90D, VAL219D, VAL229D, VAL39E, VAL45E, VAL47E, VAL68E, VAL7E
• D-F: ALA236D, ALA65F, ARG224D, ARG233D, ARG238D, ARG58F, ARG61F, ARG64F, ARG71F, ASN53F, ASP56F, ASP57F, ASP67F, GLN72F, GLN73F, GLU52F, LEU230D, LEU235D, LEU54F, LEU66F, LEU68F, LYS231D, LYS234D, LYS241D, LYS63F, LYS87F, MET70F, PHE60F, PRO239D, PRO240D, PRO51F, SER228D, SER232D, SER69F, TRP227D, TYR237D, TYR55F, VAL229D, VAL59F
• D-G: ALA221D, ALA236D, ALA25G, ARG11G, ARG224D, ARG233D, ARG238D, ARG24G, ARG71G, ASN73G, ASP2D, GLN156D, GLN23G, GLU22G, GLU4D, GLU67G, HIS12G, HIS225D, HIS28G, HIS6D, ILE14G, LEU18G, LEU216D, LEU218D, LEU230D, LEU235D, LEU3D, LEU5D, LYS223D, LYS226D, LYS231D, LYS234D, LYS241D, LYS32G, LYS68G, LYS70G, LYS72G, MET222D, PHE21G, PHE26G, PHE66G, PRO20G, PRO217D, PRO239D, PRO240D, PRO27G, SER17G, SER19G, SER1D, SER228D, SER232D, SER69G, THR15G, TRP227D, TYR16G, TYR220D, TYR237D, TYR29G, VAL10G, VAL13G, VAL219D, VAL229D
• D-H: ALA177D, ALA183D, ALA64H, ALA70H, ARG15D, ARG21H, ARG28D, ARG43H, ARG47H, ARG65H, ASN150D, ASN166D, ASN75H, ASP125D, ASP15H, ASP173D, ASP185D, ASP22D, ASP2D, ASP41H, ASP53H, ASP60H, ASP66H, CYS135D, CYS187D, CYS40H, CYS54H, CYS68H, GLN156D, GLN181D, GLN49H, GLU136D, GLU167D, GLU42H, GLU4D, GLU51H, GLU52H, GLU56H, GLU57H, GLY133D, GLY140D, GLY174D, HIS14D, HIS63H, HIS67H, HIS6D, HIS71H, LEU130D, LEU131D, LEU17H, LEU37H, LEU39H, LEU3D, LEU58H, LEU59H, LEU5D, LEU62H, LEU73H, LEU77H, LYS184D, LYS72H, LYS78H, MET179D, PHE128D, PHE149D, PHE153D, PHE171D, PHE61H, PHE74H, PRO11D, PRO137D, PRO138D, PRO151D, PRO16H, PRO176D, PRO7D, PRO8D, SER129D, SER13D, SER142D, SER180D, SER25D, SER45H, SER46H, SER48H, SER76H, SER9D, THR132D, THR139D, THR175D, THR178D, THR188D, THR18H, THR19H, THR24D, THR50H, THR55H, TRP12D, TYR10D, TYR134D, TYR152D, VAL141D, VAL182D, VAL20H, VAL44H, VAL69H
• D-J: ALA34J, ALA39J, ALA41J, ALA61D, ALA63D, ARG15D, ARG201D, ARG203D, ARG27D, ARG28D, ASN47J, ASN61J, ASP172D, ASP173D, ASP199D, ASP22D, ASP36J, ASP40J, ASP59D, CYS55D, GLN37J, GLU32J, GLU44J, GLU48J, GLU58D, GLU60D, GLU60J, GLY16D, GLY205D, GLY213D, GLY38J, GLY49J, GLY53D, HIS14D, HIS198D, HIS200D, HIS23D, HIS45J, HIS50D, HIS54J, HIS57J, ILE26D, ILE42J, ILE46J, ILE55J, LEU17D, LEU18D, LEU206D, LEU209D, LEU210D, LEU214D, LEU215D, LEU21D, LEU51D, LEU51J, LYS202D, LYS207D, LYS50J, LYS53J, LYS56J, LYS58J, LYS62J, MET204D, MET208D, MET211D, MET212D, PHE31J, PHE35J, SER13D, SER19D, SER20D, SER25D, THR24D, THR57D, TRP12D, TRP52J, TYR43J, TYR56D, TYR59J, VAL52D, VAL54D
• D-P: ALA100D, ALA100P, ASN97D, ASN97P, GLU99D, GLU99P, MET80D, MET80P, PRO96D, PRO96P
• D-Q: ALA88Q, ARG102D, ASP2D, GLU99D, GLY107D, GLY155D, GLY162Q, HIS161Q, HIS164Q, LYS85Q, MET87Q, PRO154D, PRO159Q, SER1D, TYR157Q
• E-F: ARG71F, GLN73F, TYR13E
• E-G: ALA25G, ALA31E, ARG14E, ARG15E, ARG24G, ARG32E, ASP12E, ASP4E, ASP9E, GLN23G, GLU17E, GLU22G, GLU30E, GLY34E, HIS28G, HIS2E, ILE14G, ILE5E, LEU18G, LEU19E, LEU38E, LYS32G, LYS33E, LYS6E, PHE10E, PHE21G, PHE26G, PHE35E, PRO16E, PRO20G, PRO27G, PRO8E, SER11E, SER17G, SER19G, SER25E, SER28E, SER29E, SER36E, THR15G, THR40E, TYR13E, TYR16G, TYR37E, VAL18E, VAL39E, VAL7E
• E-J: ALA21J, ALA28J, ALA31E, ALA39J, ALA41E, ALA48E, ALA50E, ALA7J, ARG15J, ARG32E, ARG33J, ARG8J, ASN53E, ASP36J, ASP40J, GLU17E, GLU27E, GLU30E, GLU32J, GLY27J, GLY34E, GLY46E, ILE24J, LEU13J, LEU22J, LEU29J, LEU38E, LEU5J, LEU9J, LYS33E, LYS52E, PHE14J, PHE20J, PHE30J, PHE31J, PHE35E, PHE35J, PRO3J, SER11J, SER28E, SER29E, SER36E, THR23J, THR40E, THR42E, THR43E, THR44E, THR4J, THR6J, TYR10J, TYR37E, TYR49E, VAL1J, VAL25J, VAL26J, VAL39E, VAL45E, VAL47E
• E-K: ALA35K, ALA48E, GLY31K, LEU32K, LYS52E, SER34K, SER56E, THR36K, VAL33K, VAL55E
• E-O: ALA173O, ALA64E, ALA70E, ARG177O, ASP171O, ASP67E, GLU162O, GLY166O, GLY167O, ILE164O, LEU160O, LEU69E, LYS172O, LYS73E, MET62E, MET71E, PHE168O, PHE181O, PHE58E, SER169O, SER60E, SER61E, SER63E, SER65E, SER72E, THR174O, TRP163O, TRP165O, VAL55E, VAL59E, VAL68E
• F-G: ALA23F, ALA24F, ALA43G, ARG11G, ARG39G, ARG40G, ARG47G, ARG48F, ARG58F, ARG61F, ARG64F, ARG71F, ARG9G, ASN22F, ASN36G, ASN53F, ASP56F, ASP57F, GLN72F, GLN73F, GLU52F, GLY25F, HIS12G, HIS6G, ILE14G, ILE47F, ILE62F, ILE74F, LEU46G, LEU50F, LEU68F, LEU75F, LEU7G, LYS28F, LYS32G, LYS44F, LYS63F, PHE26F, PHE60F, PRO27G, PRO51F, PRO76F, SER69F, THR15G, THR8G, TRP19F, TRP80F, TYR20F, TYR55F, VAL10G, VAL13G, VAL37G, VAL59F
• F-M: ALA108F, ALA288M, ARG104F, ARG356M, ARG408M, ARG49F, GLU100F, GLU351M, GLU353M, HIS289M, LEU355M, LYS109F, LYS110F, SER291M, SER352M, THR350M, TRP107F
• F-N: ALA108F, ALA46F, ALA80N, ALA91N, ARG104F, ARG133N, ARG134N, ARG48F, ARG49F, ARG87N, ARG99F, ASN53F, GLU100F, GLU103F, GLU105F, GLU106F, GLU131N, GLU136N, GLU45F, GLU52F, GLU90N, GLU96F, GLY88N, ILE85N, ILE89N, LEU50F, LEU54F, LYS84N, PHE122N, PHE83N, PRO51F, SER81N, SER82N, THR76N, THR86N, TRP107F, TRP135N, TYR55F, TYR93F, VAL92N, VAL97F
• F-W: ARG15W, LYS110F
• G-H: ALA33H, ALA64H, ALA75G, ARG36H, ARG43H, ARG47H, ARG71G, ARG81G, ASN73G, ASN79G, ASP53H, ASP60H, ASP80G, GLU51H, GLU52H, GLU56H, GLU57H, GLU78G, HIS63H, LEU59H, LYS68G, LYS70G, LYS72G, PHE61H, PRO74G, THR50H, THR55H, VAL44H
• G-J: PHE14J, PHE21G, TYR10J
• G-O: GLY1G, LEU10O
• G-S: ARG2G, ARG2S
• H-Q: ASP152Q, GLU51H
• J-K: ALA21J, ALA21K, ALA26K, ALA28J, ALA29K, ALA35K, ARG16J, ASN16K, GLN22K, GLU32J, GLY25K, GLY27J, GLY28K, GLY31K, ILE24J, LEU13J, LEU22J, LEU23K, LEU29J, LEU32K, PHE20J, PHE30J, PRO19K, SER18J, SER34K, THR17J, THR19J, THR20K, THR23J, TRP24K, VAL18K, VAL25J, VAL26J, VAL27K, VAL30K, VAL33K
• K-O: ILE156O, THR36K
• K-R: ARG15K, LYS110R
• M-N: ALA101M, ALA149N, ALA151N, ALA200M, ALA275M, ALA281N, ALA288M, ALA291N, ALA295M, ALA2M, ALA359N, ALA360N, ALA364M, ALA366N, ALA393M, ALA42N, ALA44N, ALA5M, ALA63M, ALA72N, ALA74M, ALA7M, ALA84M, ALA88M, ALA91N, ALA96M, ARG113N, ARG287N, ARG356M, ARG362M, ARG46N, ARG70N, ARG87N, ASN290N, ASN359M, ASN362N, ASN363M, ASN40N, ASN73M, ASN87M, ASP105M, ASP114N, ASP115N, ASP147N, ASP281M, ASP356N, ASP370M, CYS111N, CYS282M, CYS35M, GLN136M, GLN143N, GLN153N, GLN297N, GLN29M, GLN305M, GLN329N, GLN32M, GLN358N, GLN6M, GLN9M, GLU110N, GLU130M, GLU136N, GLU137M, GLU168M, GLU28M, GLU353M, GLU373N, GLU376N, GLU396M, GLU39N, GLU60M, GLU76M, GLU78M, GLU80M, GLU90N, GLY201M, GLY210N, GLY282N, GLY285M, GLY286M, GLY287M, GLY288N, GLY357M, GLY367N, GLY371M, GLY377N, GLY72M, GLY83M, GLY88N, GLY93N, GLY94N, HIS277N, HIS279M, HIS284N, HIS289M, HIS368M, HIS61M, HIS85M, ILE116M, ILE118N, ILE134M, ILE146N, ILE297M, ILE85N, ILE89N, ILE99M, LEU102M, LEU112N, LEU119N, LEU140N, LEU209N, LEU250M, LEU252N, LEU290M, LEU355M, LEU360M, LEU361M, LEU364N, LEU365M, LEU369M, LEU369N, LEU392M, LEU399N, LEU62M, LEU71N, LEU75M, LEU75N, LEU86M, LEU8M, LEU96N, LYS100M, LYS104M, LYS148N, LYS286N, LYS302M, LYS358M, LYS361N, LYS363N, LYS365N, LYS65M, LYS77M, LYS84N, LYS95N, MET370N, MET82M, PHE378N, PHE58M, PHE64M, PHE83N, PRO12M, PRO214N, PRO283N, PRO293M, PRO306N, PRO33M, PRO355N, PRO374M, PRO395N, PRO43N, SER103M, SER10M, SER212N, SER289N, SER291M, SER292M, SER293N, SER296M, SER30M, SER352M, SER367M, SER371N, SER374N, SER375N, SER396N, SER45N, SER73N, SER74N, SER81M, SER81N, SER82N, SER90M, THR1M, THR283M, THR292N, THR34M, THR36M, THR372M, THR373M, THR3M, THR76N, THR86N, TYR280M, TYR284M, TYR368N, TYR41N, TYR4M, TYR57M, TYR89M, TYR97M, TYR98M, VAL11M, VAL133M, VAL150N, VAL167M, VAL211N, VAL285N, VAL366M, VAL372N, VAL375M, VAL59M, VAL79M, VAL92N
• M-O: ARG244M, ARG436M, ARG438M, ARG445M, ARG5O, ASN16O, ASN301M, ASN3O, ASN435M, ASP20O, ASP214O, ASP216O, ASP332M, ASP333M, ASP433M, GLU429M, HIS221O, ILE19O, ILE218O, ILE226O, ILE297M, ILE437M, ILE4O, LEU21O, LEU303M, LEU431M, LEU444M, LYS12O, LYS217O, LYS302M, LYS6O, MET1O, PHE18O, PHE220O, PHE336M, PHE442M, PHE446M, PRO219O, PRO222O, PRO432M, SER439M, SER7O, THR225O, THR2O, THR300M, TRP443M, TYR223O, TYR434M, VAL215O, VAL337M
• M-P: ALA236P, ARG224P, ARG233P, ARG238P, ARG244M, ARG436M, ARG438M, ASN435M, ASP433M, CYS242M, CYS419M, GLN240M, GLU245M, GLY238M, HIS225P, HIS243M, ILE241M, ILE437M, LEU230P, LEU235P, LEU431M, LYS226P, LYS234P, PHE442M, PRO239P, PRO240P, PRO432M, SER171M, SER228P, SER239M, SER439M, TRP227P, TYR152M, TYR237P, TYR434M, VAL229P
• M-Q: ALA155M, ALA157M, ALA164M, ARG146M, ARG14Q, ARG15Q, ARG235M, ARG32Q, ARG438M, ARG92M, ASN141M, ASN151M, ASN173M, ASN53M, ASP142M, ASP147M, ASP20Q, ASP316M, ASP417M, ASP4Q, ASP9Q, CYS234M, CYS419M, GLN139M, GLN159M, GLN165M, GLN240M, GLN418M, GLU137M, GLU140M, GLU168M, GLU172M, GLU17Q, GLU258M, GLU27Q, GLU30Q, GLY160M, GLY169M, GLY238M, GLY259M, GLY318M, GLY34Q, HIS154M, HIS243M, HIS264M, HIS2Q, ILE241M, ILE5Q, LEU135M, LEU138M, LEU153M, LEU19Q, LEU231M, LEU320M, LYS23Q, LYS26Q, LYS33Q, LYS413M, LYS6Q, MET145M, PHE10Q, PHE150M, PHE158M, PHE236M, PHE415M, PHE425M, PHE442M, PRO162M, PRO170M, PRO229M, PRO233M, PRO260M, PRO8Q, SER11Q, SER144M, SER166M, SER171M, SER1Q, SER21Q, SER232M, SER239M, SER24Q, SER25Q, SER28Q, SER29Q, SER36Q, SER412M, SER439M, THR143M, THR156M, THR161M, THR22Q, THR237M, THR317M, THR3Q, TYR152M, TYR37Q, TYR414M, TYR416M, TYR434M, VAL148M, VAL149M, VAL167M, VAL18Q, VAL257M, VAL7Q
• M-R: ARG244M, ASP246M, ASP56R, CYS242M, GLU245M, GLU429M, GLU52R, LYS63R, TYR55R, VAL59R
• M-S: ALA155M, ALA157M, ALA423M, ARG11S, ARG235M, ARG244M, ARG2S, ARG436M, ARG438M, ARG9S, ASN435M, ASP246M, ASP332M, ASP417M, ASP433M, CYS242M, CYS419M, GLN159M, GLN23S, GLN240M, GLN3S, GLN418M, GLN430M, GLU22S, GLU245M, GLU258M, GLU429M, GLY238M, GLY247M, GLY424M, GLY426M, GLY5S, HIS12S, HIS243M, HIS328M, HIS6S, ILE14S, ILE241M, ILE331M, ILE428M, ILE437M, LEU18S, LEU248M, LEU431M, LEU7S, MET329M, PHE21S, PHE236M, PHE425M, PHE442M, PHE4S, PRO20S, PRO249M, PRO420M, PRO427M, PRO432M, SER17S, SER19S, SER239M, SER330M, SER439M, THR156M, THR15S, THR237M, THR8S, TYR152M, TYR16S, TYR434M, VAL10S, VAL13S, VAL148M, VAL422M
• M-U: ALA74U, ARG47U, ARG52U, ASN141M, ASN71U, ASP132M, ASP142M, ASP147M, ASP281M, CYS282M, CYS51U, GLN126M, GLN136M, GLN139M, GLU130M, GLU137M, GLU140M, GLU53U, GLU60M, GLY278M, GLY285M, GLY286M, GLY287M, HIS279M, HIS289M, HIS61M, ILE134M, LEU248M, LEU290M, LEU360M, LEU50U, LEU62M, LEU70U, LYS129M, LYS46U, LYS65M, MET145M, PHE64M, PRO249M, PRO73U, SER144M, SER48U, SER54U, SER69U, SER75U, THR143M, THR283M, TYR280M, TYR284M, VAL133M, VAL49U, VAL68U, VAL72U
• M-V: ALA21V, ARG15V, ARG16V, ARG408M, ARG438M, ARG445M, ASP417M, CYS346M, CYS411M, GLN418M, GLU409M, LEU444M, LYS413M, PHE14V, PHE20V, PHE415M, PHE442M, SER18V, SER412M, THR17V, THR347M, TRP443M, TYR10V, TYR414M, TYR416M, VAL410M
• M-W: ALA349M, ALA404M, ARG15W, ARG344M, ARG405M, ARG408M, ASN16W, ASP403M, CYS346M, GLU351M, GLU409M, LEU345M, LEU444M, MET343M, SER348M, SER352M, SER412M, THR20W, THR347M, THR350M, TRP17W, TRP24W, TRP443M, VAL406M
• N-U: ALA106N, ALA151N, ALA157N, ALA256N, ALA281N, ALA311N, ALA314N, ALA386N, ALA388N, ALA389N, ALA59U, ALA60U, ALA66U, ALA72N, ALA74U, ARG102N, ARG287N, ARG46N, ARG47U, ARG52U, ARG56U, ARG62U, ARG70N, ARG77U, ARG87N, ASN104N, ASN154N, ASN290N, ASN313N, ASN71U, ASP147N, ASP250N, ASP308N, ASP380N, CYS51U, GLN143N, GLN153N, GLN156N, GLN276N, GLN305N, GLN329N, GLN385N, GLN401N, GLN58U, GLU103N, GLU110N, GLU161N, GLU376N, GLU381N, GLU53U, GLU90N, GLY265N, GLY280N, GLY282N, GLY288N, GLY320N, GLY323N, GLY377N, GLY383N, GLY390N, GLY57U, GLY61U, GLY88N, GLY93N, GLY94N, HIS158N, HIS164N, HIS254N, HIS277N, HIS284N, HIS67N, ILE160N, ILE264N, ILE327N, ILE402N, ILE85N, ILE89N, LEU152N, LEU163N, LEU172N, LEU176N, LEU252N, LEU321N, LEU364N, LEU387N, LEU50U, LEU55U, LEU64U, LEU68N, LEU69N, LEU70U, LEU71N, LEU96N, LYS148N, LYS286N, LYS46U, LYS95N, MET105N, PHE307N, PHE312N, PHE322N, PHE324N, PHE50N, PRO155N, PRO283N, PRO306N, PRO63U, PRO73U, SER100N, SER175N, SER251N, SER273N, SER289N, SER310N, SER315N, SER371N, SER384N, SER391N, SER48U, SER54U, SER66N, SER67U, SER69U, SER73N, SER74N, SER75U, SER82N, SER97N, THR101N, THR108N, THR326N, THR393N, THR86N, THR99N, TYR107N, TYR168N, TYR177N, TYR296N, TYR316N, TYR325N, TYR368N, TYR392N, TYR78U, VAL109N, VAL126N, VAL150N, VAL159N, VAL258N, VAL285N, VAL309N, VAL372N, VAL382N, VAL398N, VAL49U, VAL65U, VAL68U, VAL72U, VAL76U, VAL98N
• O-P: ALA119P, ALA193P, ALA194P, ALA221P, ALA232O, ALA238O, ALA23O, ALA246O, ALA47P, ARG102P, ARG118P, ARG120P, ARG191P, ARG201P, ARG203P, ARG224P, ARG233P, ARG49P, ARG71O, ARG80O, ASN255O, ASN260O, ASN263O, ASN26O, ASN32O, ASP112P, ASP199P, ASP216O, ASP228O, ASP248O, ASP252O, ASP254O, ASP44P, ASP72O, CYS70O, GLN137O, GLU195P, GLU197P, GLU344O, GLY122P, GLY123P, GLY16P, GLY205P, GLY213P, GLY231O, HIS121P, HIS198P, HIS200P, HIS221O, HIS225P, HIS267O, HIS68O, ILE116P, ILE218O, ILE226O, ILE229O, ILE236O, ILE27O, ILE78O, ILE79O, LEU109P, LEU17P, LEU18P, LEU190P, LEU206P, LEU209P, LEU210P, LEU214P, LEU215P, LEU216P, LEU218P, LEU230O, LEU230P, LEU233O, LEU234O, LEU235O, LEU235P, LEU237O, LEU239O, LEU241O, LEU242O, LEU244O, LEU249O, LEU262O, LYS202P, LYS207P, LYS217O, LYS223P, LYS226P, LYS227O, LYS231P, LYS269O, MET204P, MET208P, MET211P, MET212P, MET222P, MET240O, MET43P, MET82O, PHE189P, PHE220O, PHE245O, PHE63O, PRO111P, PRO154P, PRO196P, PRO217P, PRO219O, PRO222O, PRO247O, PRO24O, PRO253O, PRO258O, PRO266O, PRO342O, SER114P, SER19P, SER1P, SER228P, SER25O, SER29O, SER64O, SER65O, SER88P, THR225O, THR257O, THR60O, THR61O, THR67O, TRP192P, TRP227P, TRP77O, TYR115P, TYR220P, TYR223O, TYR224O, TYR256O, TYR45P, TYR75O, TYR81O, TYR90P, VAL117P, VAL219P, VAL229P, VAL243O, VAL46P, VAL73O
• O-Q: ALA50Q, ALA64Q, ALA66Q, ALA70Q, ARG71O, ARG80O, ASN53Q, ASN74O, ASP67Q, ASP72O, GLN57Q, GLY48O, GLY76O, HIS54O, HIS68O, HIS83O, ILE226O, ILE229O, ILE236O, ILE42O, ILE69O, ILE78O, ILE79O, LEU233O, LEU244O, LEU43O, LEU46O, LEU49O, LEU51O, LEU69Q, MET240O, MET53O, MET62Q, MET82O, PHE50O, PHE58Q, SER56Q, SER60Q, SER61Q, SER63Q, SER65Q, THR43Q, THR47O, TRP77O, TYR75O, VAL47Q, VAL54Q, VAL55Q, VAL59Q, VAL68Q, VAL73O
• O-R: ALA23R, ALA24R, ALA369O, ALA65R, ARG17R, ARG313O, ARG318O, ARG33R, ARG48R, ARG58R, ARG61R, ARG64R, ARG71R, ASN206O, ASN207O, ASN22R, ASN26O, ASN27R, ASN374O, ASN40R, ASP214O, ASP216O, ASP34R, ASP35R, ASP67R, ASP86R, CYS323O, GLN312O, GLN322O, GLN72R, GLU14R, GLU373O, GLU39R, GLU91R, GLY105O, GLY15R, GLY210O, GLY25R, GLY370O, HIS308O, HIS38R, ILE16R, ILE211O, ILE218O, ILE27O, ILE372O, ILE37R, ILE47R, ILE62R, ILE74R, ILE98R, LEU13R, LEU29R, LEU31R, LEU320O, LEU376O, LEU377O, LEU66R, LEU68R, LEU90R, LEU94R, LYS18R, LYS217O, LYS227O, LYS28R, LYS311O, LYS375O, LYS378O, LYS44R, LYS63R, LYS87R, LYS95R, MET315O, MET316O, MET32R, MET70R, PHE109O, PHE26R, PHE317O, PHE60R, PRO208O, PRO24O, PRO319O, PRO92R, SER106O, SER212O, SER213O, SER25O, SER28O, SER29O, SER310O, SER314O, SER321O, SER69R, SER88R, THR108O, THR209O, THR36R, THR371O, TRP19R, TRP30O, TRP379O, TYR104O, TYR107O, TYR20R, TYR21R, TYR224O, TYR55R, TYR83R, VAL215O, VAL43R, VAL59R
• O-S: ALA17O, ALA23O, ALA327O, ALA330O, ALA354O, ALA43S, ALA49S, ALA54S, ARG2S, ARG318O, ARG40S, ARG47S, ARG9S, ASP20O, ASP214O, ASP216O, ASP331O, CYS323O, CYS44S, GLN322O, GLN341O, GLN3S, GLN64S, GLU202O, GLU344O, GLU373O, GLU65S, GLU67S, GLY1S, GLY204O, GLY5S, GLY62S, HIS201O, HIS221O, HIS345O, HIS6S, ILE19O, ILE218O, ILE338O, ILE348O, ILE350O, ILE45S, LEU200O, LEU21O, LEU320O, LEU324O, LEU328O, LEU332O, LEU333O, LEU335O, LEU353O, LEU357O, LEU361O, LEU46S, LEU57S, LEU7S, LYS217O, LYS68S, LYS70S, MET315O, MET316O, PHE220O, PHE317O, PHE325O, PHE4S, PHE52S, PHE55S, PHE66S, PRO20S, PRO219O, PRO222O, PRO22O, PRO24O, PRO319O, PRO342O, PRO346O, PRO50S, PRO51S, SER17S, SER212O, SER213O, SER28O, SER29O, SER321O, SER69S, THR15S, THR203O, THR334O, THR336O, THR349O, THR60S, THR63S, THR8S, TRP326O, TRP337O, TRP61S, TYR103O, TYR223O, TYR347O, TYR56S, TYR59S, VAL10S, VAL13S, VAL215O, VAL329O, VAL343O, VAL48S, VAL53S, VAL58S
• O-V: PHE245O, TYR43V
• O-W: ARG5O, TRP17W
• P-Q: ALA221P, ALA236P, ALA41Q, ALA47P, ALA48Q, ALA50Q, ALA51Q, ALA66Q, ALA70Q, ARG14Q, ARG15Q, ARG201P, ARG224P, ARG233P, ARG238P, ARG32Q, ARG49P, ARG83P, ASN53Q, ASP12Q, ASP4Q, ASP67Q, ASP80Q, ASP89P, ASP9Q, GLN57Q, GLU58P, GLU66P, GLU75Q, GLU79P, GLY46Q, GLY85P, HIS200P, HIS225P, HIS2Q, ILE194Q, ILE5Q, ILE74Q, ILE76Q, LEU210P, LEU214P, LEU215P, LEU216P, LEU218P, LEU235P, LEU38Q, LEU78Q, LEU87P, LYS207P, LYS223P, LYS226P, LYS231P, LYS234P, LYS33Q, LYS62P, LYS6Q, LYS73Q, LYS77Q, LYS86P, MET192Q, MET204P, MET208P, MET211P, MET212P, MET222P, MET71Q, MET82P, PHE10Q, PHE35Q, PHE81P, PHE89Q, PRO217P, PRO84P, PRO8Q, SER1Q, SER228P, SER232P, SER36Q, SER88P, THR188Q, THR3Q, THR40Q, THR42Q, THR43Q, THR44Q, TYR13Q, TYR220P, TYR37Q, TYR49Q, TYR90P, VAL219P, VAL229P, VAL39Q, VAL45Q, VAL47Q, VAL54Q, VAL68Q, VAL7Q
• P-R: ALA236P, ALA65R, ARG224P, ARG233P, ARG238P, ARG58R, ARG61R, ARG64R, ARG71R, ASN53R, ASP56R, ASP57R, ASP67R, GLN72R, GLN73R, GLU52R, LEU230P, LEU235P, LEU54R, LEU66R, LEU68R, LYS231P, LYS234P, LYS241P, LYS63R, LYS87R, MET70R, PHE60R, PRO239P, PRO240P, PRO51R, SER228P, SER232P, SER69R, TRP227P, TYR237P, TYR55R, VAL59R
• P-S: ALA221P, ALA236P, ALA25S, ARG11S, ARG224P, ARG233P, ARG238P, ARG24S, ARG71S, ASN73S, ASP2P, GLN156P, GLN23S, GLU22S, GLU4P, GLU67S, HIS12S, HIS225P, HIS28S, HIS6P, ILE14S, LEU18S, LEU216P, LEU218P, LEU230P, LEU235P, LEU3P, LEU5P, LYS223P, LYS226P, LYS231P, LYS234P, LYS241P, LYS32S, LYS68S, LYS70S, LYS72S, MET222P, PHE21S, PHE26S, PHE66S, PRO20S, PRO217P, PRO239P, PRO240P, PRO27S, SER17S, SER19S, SER1P, SER228P, SER232P, SER69S, THR15S, TRP227P, TYR16S, TYR220P, TYR237P, TYR29S, VAL10S, VAL13S, VAL219P, VAL229P
• P-T: ALA177P, ALA183P, ALA64T, ALA70T, ARG15P, ARG21T, ARG28P, ARG43T, ARG47T, ARG65T, ASN150P, ASN166P, ASN75T, ASP125P, ASP15T, ASP173P, ASP185P, ASP22P, ASP2P, ASP41T, ASP53T, ASP60T, ASP66T, CYS135P, CYS187P, CYS40T, CYS54T, CYS68T, GLN156P, GLN181P, GLN49T, GLU136P, GLU167P, GLU42T, GLU4P, GLU51T, GLU52T, GLU56T, GLU57T, GLY133P, GLY140P, GLY174P, HIS14P, HIS63T, HIS67T, HIS6P, HIS71T, LEU130P, LEU131P, LEU17T, LEU37T, LEU39T, LEU3P, LEU58T, LEU59T, LEU5P, LEU62T, LEU73T, LEU77T, LYS184P, LYS72T, LYS78T, MET179P, PHE128P, PHE149P, PHE153P, PHE171P, PHE61T, PHE74T, PRO11P, PRO137P, PRO138P, PRO151P, PRO16T, PRO176P, PRO7P, PRO8P, SER129P, SER13P, SER142P, SER180P, SER25P, SER45T, SER46T, SER48T, SER76T, SER9P, THR132P, THR139P, THR175P, THR178P, THR188P, THR18T, THR19T, THR24P, THR50T, THR55T, TRP12P, TYR10P, TYR134P, TYR152P, VAL141P, VAL182P, VAL20T, VAL44T, VAL69T
• P-V: ALA34V, ALA39V, ALA41V, ALA61P, ARG15P, ARG201P, ARG203P, ARG27P, ARG28P, ASN47V, ASN61V, ASP172P, ASP173P, ASP199P, ASP22P, ASP36V, ASP40V, ASP59P, CYS55P, GLN37V, GLU32V, GLU44V, GLU48V, GLU58P, GLU60P, GLU60V, GLY16P, GLY205P, GLY213P, GLY38V, GLY49V, GLY53P, HIS14P, HIS198P, HIS200P, HIS23P, HIS45V, HIS50P, HIS54V, HIS57V, ILE26P, ILE42V, ILE46V, ILE55V, LEU17P, LEU18P, LEU206P, LEU209P, LEU210P, LEU214P, LEU215P, LEU21P, LEU51P, LEU51V, LYS184P, LYS202P, LYS207P, LYS50V, LYS53V, LYS56V, LYS58V, MET204P, MET208P, MET211P, MET212P, PHE31V, PHE35V, SER13P, SER19P, SER20P, SER25P, THR24P, THR57P, TRP12P, TRP52V, TYR43V, TYR56P, TYR59V, VAL52P, VAL54P
• Q-R: ARG71R, GLN73R, TYR13Q
• Q-S: ALA25S, ALA31Q, ARG14Q, ARG15Q, ARG24S, ARG32Q, ASP12Q, ASP9Q, GLN23S, GLU17Q, GLU22S, GLY34Q, HIS28S, HIS2Q, ILE14S, ILE5Q, LEU18S, LEU19Q, LEU38Q, LYS32S, LYS33Q, LYS6Q, PHE10Q, PHE21S, PHE26S, PHE35Q, PRO16Q, PRO20S, PRO27S, PRO8Q, SER11Q, SER17S, SER19S, SER25Q, SER28Q, SER29Q, SER36Q, THR15S, TYR13Q, TYR16S, TYR37Q, VAL18Q, VAL39Q, VAL7Q
• Q-V: ALA21V, ALA28V, ALA2V, ALA31Q, ALA34V, ALA39V, ALA41Q, ALA48Q, ALA50Q, ALA7V, ARG15V, ARG32Q, ARG33V, ARG8V, ASN53Q, ASP36V, ASP40V, GLN37V, GLU17Q, GLU27Q, GLU30Q, GLU32V, GLY27V, GLY34Q, GLY46Q, ILE24V, LEU13V, LEU22V, LEU29V, LEU38Q, LEU5V, LEU9V, LYS33Q, LYS52Q, PHE14V, PHE20V, PHE30V, PHE31V, PHE35Q, PHE35V, PRO3V, SER11V, SER28Q, SER29Q, SER36Q, THR23V, THR40Q, THR42Q, THR43Q, THR44Q, THR4V, THR6V, TYR10V, TYR37Q, TYR49Q, VAL1V, VAL25V, VAL26V, VAL39Q, VAL45Q, VAL47Q
• Q-W: ALA35W, ALA48Q, GLY31W, LEU32W, LYS52Q, SER34W, SER56Q, THR36W, VAL33W, VAL55Q
• R-S: ALA23R, ALA24R, ALA43S, ARG11S, ARG39S, ARG40S, ARG42S, ARG47S, ARG48R, ARG58R, ARG61R, ARG64R, ARG71R, ARG9S, ASN22R, ASN36S, ASN53R, ASP56R, ASP57R, ASP67R, GLN72R, GLN73R, GLU52R, GLY25R, HIS12S, HIS6S, ILE14S, ILE47R, ILE62R, ILE74R, LEU46S, LEU50R, LEU68R, LEU75R, LEU7S, LYS28R, LYS32S, LYS44R, LYS63R, MET70R, PHE26R, PHE60R, PRO27S, PRO51R, PRO76R, SER69R, THR15S, THR8S, TRP19R, TRP80R, TYR20R, TYR55R, VAL10S, VAL13S, VAL37S, VAL59R
• S-T: ALA33T, ALA64T, ALA75S, ARG36T, ARG43T, ARG47T, ARG71S, ARG81S, ASN73S, ASN79S, ASP53T, ASP60T, ASP80S, GLU51T, GLU52T, GLU56T, GLU57T, GLU78S, HIS63T, LEU59T, LYS68S, LYS70S, LYS72S, PHE61T, PRO74S, THR50T, THR55T, VAL44T
• S-V: PHE21S, TYR10V
• V-W: ALA21V, ALA21W, ALA26W, ALA28V, ALA29W, ALA35W, ARG16V, ASN16W, GLN22W, GLU32V, GLY25W, GLY27V, GLY28W, GLY31W, ILE24V, LEU13V, LEU22V, LEU23W, LEU29V, LEU32W, PHE20V, PHE30V, PRO19W, SER18V, SER34W, THR17V, THR19V, THR20W, THR23V, TRP24W, VAL18W, VAL25V, VAL26V, VAL27W, VAL30W, VAL33W