1B3S

structural response to mutation at a protein-protein interface

• Total interactions analyzed: 15
• Total true interactions: 7
• Strongest Interaction:
  • Chains: C-F
  • Int. Res.: 71
  • Norm. En. per Res.: -5.0298
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	0.0	-2.1601	-64.6766	-66.8367	26	1	1	2726	0	12	9
A-C	-16.1432	13.663	-48.604	-51.0843	40	1	0	2116	0	4	8
A-D	-34.605	-72.9442	-212.043	-319.5922	75	11	5	7443	8	29	27
B-C	0.0	-1.9858	-35.2616	-37.2474	25	1	0	1461	0	10	7
B-E	-54.4502	-81.0975	-221.597	-357.1448	75	5	4	7687	9	29	25
C-E	0.0	0.0	-0.0044	-0.0044	4	0	0	6	0	4	2
C-F	-51.6544	-91.5998	-213.862	-357.1163	71	8	4	7123	10	29	26

Interface residues

• A-B: ALA11A, ALA11B, ARG110A, ARG110B, ASP12A, ASP12B, ASP8A, ASP8B, GLN15A, GLN15B, ILE109A, ILE109B, ILE96A, ILE96B, LYS108A, LYS108B, LYS98A, LYS98B, PHE106A, PHE106B, PHE7A, PHE7B, THR107A, THR107B, TYR97A, TYR97B
• A-C: ALA11C, ALA1A, ARG110C, ASN23A, ASN5A, ASN5C, ASN77A, ASN77C, ASP12C, ASP8A, ASP8C, GLN15C, GLN2A, GLY48A, GLY9A, GLY9C, ILE109C, ILE4A, ILE4C, ILE76A, ILE76C, ILE88C, LYS98C, PHE7A, PHE7C, SER80A, THR100C, THR107C, THR16C, THR6A, THR6C, THR79A, THR79C, TYR13C, TYR24A, TYR78A, VAL10A, VAL10C, VAL3A, VAL3C
• A-D: ALA102A, ALA26D, ALA37A, ALA37D, ALA78D, ARG59A, ARG83A, ARG87A, ASN34D, ASN58A, ASN84A, ASP101A, ASP36D, ASP40D, ASP54A, ASP75A, CYS41D, CYS83D, GLN104A, GLN31A, GLN73D, GLU29D, GLU33D, GLU47D, GLU60A, GLU73A, GLU77D, GLU81D, GLY32D, GLY40A, GLY44D, GLY61A, GLY81A, GLY82D, HIS18D, ILE14D, ILE51A, ILE55A, LEU25D, LEU35D, LEU38D, LEU42D, LEU63A, LEU89A, LYS22D, LYS27A, LYS2D, LYS39A, LYS62A, PHE106A, PHE30D, PHE56A, PHE75D, PHE82A, PRO28D, SER28A, SER38A, SER57A, SER70D, SER85A, THR100A, THR105A, THR43D, THR99A, TRP35A, TRP39D, TRP45D, TYR103A, TYR31D, TYR48D, TYR78A, VAL36A, VAL46D, VAL71D, VAL74D
• B-C: ARG59B, ASN58B, ASP101B, ASP93C, GLN104B, GLN15C, GLU60B, GLY61B, HIS18C, LEU14C, LEU63B, LYS108B, LYS19C, LYS62B, PHE106B, PRO64B, SER92C, THR105B, THR107B, THR16C, TRP94C, TYR103B, TYR13C, TYR17C, TYR97B
• B-E: ALA102B, ALA26E, ALA37B, ALA37E, ALA78E, ARG59B, ARG83B, ARG87B, ASN34E, ASN58B, ASN84B, ASP101B, ASP36E, ASP40E, ASP54B, ASP75B, ASP84E, ASP86B, CYS41E, CYS83E, GLN104B, GLN31B, GLN73E, GLU29E, GLU33E, GLU47E, GLU60B, GLU73B, GLU77E, GLU81E, GLY32E, GLY40B, GLY44E, GLY61B, GLY81B, GLY82E, HIS18E, ILE14E, ILE51B, ILE55B, LEU35E, LEU38E, LEU42E, LEU63B, LEU89B, LYS22E, LYS27B, LYS39B, LYS62B, PHE106B, PHE30E, PHE56B, PHE75E, PHE82B, PRO28E, SER28B, SER38B, SER57B, SER70E, SER85B, THR100B, THR105B, THR43E, THR99B, TRP35B, TRP39E, TRP45E, TYR103B, TYR31E, TYR48E, TYR78B, VAL36B, VAL46E, VAL71E, VAL74E
• C-E: ASN34E, HIS18C, LYS19C, SER15E
• C-F: ALA102C, ALA26F, ALA37C, ALA37F, ALA78F, ARG59C, ARG83C, ARG87C, ASN34F, ASN58C, ASN66F, ASN84C, ASP101C, ASP36F, ASP40F, ASP54C, ASP75C, CYS41F, GLN104C, GLN31C, GLN73F, GLU29F, GLU33F, GLU47F, GLU60C, GLU73C, GLU77F, GLU81F, GLY32F, GLY40C, GLY44F, GLY61C, GLY81C, HIS18F, ILE14F, ILE51C, ILE55C, LEU35F, LEU38F, LEU42F, LEU63C, LEU89C, LYS27C, LYS39C, LYS62C, PHE106C, PHE30F, PHE56C, PHE75F, PHE82C, PRO28F, SER28C, SER38C, SER57C, SER70F, SER85C, THR100C, THR105C, THR43F, THR99C, TRP35C, TRP39F, TRP45F, TYR103C, TYR31F, TYR48F, TYR78C, VAL36C, VAL46F, VAL71F, VAL74F