BLASTP 2.1.2 [Oct-19-2000] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= 1exba (324 letters) Database: data/pdbaa 12,515 sequences; 2,731,406 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value pdb|1EXB|A Chain A, Structure Of The Cytoplasmic Beta Subunit-T1... 630 0.0 pdb|1QRQ|A Chain A, Structure Of A Voltage-Dependent K+ Channel ... 629 0.0 pdb|1GVE|A Chain A, Aflatoxin Aldehyde Reductase (Akr7a1) From R... 75 2e-14 pdb|1GVE|B Chain B, Aflatoxin Aldehyde Reductase (Akr7a1) From R... 74 3e-14 pdb|1AE4| Aldehyde Reductase Complexed With Cofactor And Inhib... 38 0.002 pdb|1CWN| Crystal Structure Of Porcine Aldehyde Reductase Holo... 38 0.002 pdb|2ALR| Aldehyde Reductase 38 0.002 pdb|1HQT|A Chain A, The Crystal Structure Of An Aldehyde Reducta... 37 0.004 >pdb|1EXB|A Chain A, Structure Of The Cytoplasmic Beta Subunit-T1 Assembly Of Voltage-Dependent K Channels Length = 332 Score = 630 bits (1609), Expect = 0.0 Identities = 324/326 (99%), Positives = 324/326 (99%), Gaps = 2/326 (0%) Query: 1 LQFYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKA 60 LQFYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKA Sbjct: 1 LQFYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKA 60 Query: 61 EVVLGNIIKKKG-RRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVV 119 EVVLGNIIKKKG RRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVV Sbjct: 61 EVVLGNIIKKKGWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVV 120 Query: 120 FANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLIPPICEQA 179 FANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLIPPICEQA Sbjct: 121 FANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLIPPICEQA 180 Query: 180 EYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKD 239 EYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKD Sbjct: 181 EYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKD 240 Query: 240 KILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNAEQLMENIG 299 KILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNAEQLMENIG Sbjct: 241 KILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNAEQLMENIG 300 Query: 300 AIQVLPKLSSSIVHEIDSILG-KPYS 324 AIQVLPKLSSSIVHEIDSILG KPYS Sbjct: 301 AIQVLPKLSSSIVHEIDSILGNKPYS 326 >pdb|1QRQ|A Chain A, Structure Of A Voltage-Dependent K+ Channel Beta Subunit pdb|1QRQ|B Chain B, Structure Of A Voltage-Dependent K+ Channel Beta Subunit pdb|1QRQ|C Chain C, Structure Of A Voltage-Dependent K+ Channel Beta Subunit pdb|1QRQ|D Chain D, Structure Of A Voltage-Dependent K+ Channel Beta Subunit Length = 325 Score = 629 bits (1605), Expect = 0.0 Identities = 323/325 (99%), Positives = 323/325 (99%), Gaps = 2/325 (0%) Query: 1 LQFYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKA 60 LQFYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKA Sbjct: 1 LQFYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKA 60 Query: 61 EVVLGNIIKKKG-RRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVV 119 EVVLGNIIKKKG RRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVV Sbjct: 61 EVVLGNIIKKKGWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVV 120 Query: 120 FANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLIPPICEQA 179 FANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLIPPICEQA Sbjct: 121 FANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLIPPICEQA 180 Query: 180 EYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKD 239 EYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKD Sbjct: 181 EYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKD 240 Query: 240 KILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNAEQLMENIG 299 KILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNAEQLMENIG Sbjct: 241 KILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNAEQLMENIG 300 Query: 300 AIQVLPKLSSSIVHEIDSILG-KPY 323 AIQVLPKLSSSIVHEIDSILG KPY Sbjct: 301 AIQVLPKLSSSIVHEIDSILGNKPY 325 >pdb|1GVE|A Chain A, Aflatoxin Aldehyde Reductase (Akr7a1) From Rat Liver Length = 327 Score = 74.7 bits (181), Expect = 2e-14 Identities = 81/280 (28%), Positives = 133/280 (46%), Gaps = 20/280 (7%) Query: 50 DTAEVYAAGKAEVVLGNIIKKKGRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLE 109 DTA VYA G++E +LG++ GR V KI + L + L+ SL+ Sbjct: 40 DTAFVYANGQSETILGDLGLGLGRSGCKV---KIATKAAPMFGKTLKPADVRFQLETSLK 96 Query: 110 RLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQF 169 RLQ VD+ + + PD TP+EET++A + +G + G S + S E+ E ++ ++ Sbjct: 97 RLQCPRVDLFYLHFPDHGTPIEETLQACHQLHQEGKFVELGLSNYVSWEVAEICTLCKKN 156 Query: 170 NLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKY----DSGIPP 225 I P Q Y+ R+ VE +L G+ ++PLA G+++G+Y G P Sbjct: 157 GWIMPTVYQGMYNAITRQ-VETELFPCLRHFGLRFYAFNPLAGGLLTGRYKYQDKDGKNP 215 Query: 226 YSRASLKGY-QWLKDKILSEEGRRQQAKLKELQAIAERLGCTLPQL---AIAWC-----L 276 SR + Q D+ EE A ++ +A+ G T P + A+ W L Sbjct: 216 ESRFFGNPFSQLYMDRYWKEEHFNGIALVE--KALKTTYGPTAPSMISAAVRWMYHHSQL 273 Query: 277 RNEGVSSVLLGASNAEQLMENIGAIQVLPKLSSSIVHEID 316 + +V+LG S+ EQL +N+ ++ P L ++V D Sbjct: 274 KGTQGDAVILGMSSLEQLEQNLALVEEGP-LEPAVVDAFD 312 >pdb|1GVE|B Chain B, Aflatoxin Aldehyde Reductase (Akr7a1) From Rat Liver Length = 327 Score = 73.9 bits (179), Expect = 3e-14 Identities = 81/280 (28%), Positives = 133/280 (46%), Gaps = 20/280 (7%) Query: 50 DTAEVYAAGKAEVVLGNIIKKKGRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLE 109 DTA VYA G++E +LG++ GR V KI + L + L+ SL+ Sbjct: 40 DTAFVYANGQSETILGDLGLGLGRSGCKV---KIATKAAPMFGKTLKPADVRFQLETSLK 96 Query: 110 RLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQF 169 RLQ VD+ + + PD TP+EET++A + +G + G S + S E+ E ++ ++ Sbjct: 97 RLQCPRVDLFYLHFPDHGTPIEETLQACHQLHQEGKFVELGLSNYVSWEVAEICTLCKKN 156 Query: 170 NLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKY----DSGIPP 225 I P Q Y+ R+ VE +L G+ ++PLA G+++G+Y G P Sbjct: 157 GWIMPTVYQGMYNAITRQ-VETELFPCLRHFGLRFYAFNPLAGGLLTGRYKYQDKDGKNP 215 Query: 226 YSRASLKGY-QWLKDKILSEEGRRQQAKLKELQAIAERLGCTLPQL---AIAWC-----L 276 SR + Q D+ EE A ++ +A+ G T P + A+ W L Sbjct: 216 ESRFFGNPFSQLYMDRDWKEEHFNGIALVE--KALKTTYGPTAPSMISAAVRWMYHHSQL 273 Query: 277 RNEGVSSVLLGASNAEQLMENIGAIQVLPKLSSSIVHEID 316 + +V+LG S+ EQL +N+ ++ P L ++V D Sbjct: 274 KGTQGDAVILGMSSLEQLEQNLALVEEGP-LEPAVVDAFD 312 >pdb|1AE4| Aldehyde Reductase Complexed With Cofactor And Inhibitor, Alpha Carbon Atoms Only Length = 325 Score = 38.0 bits (87), Expect = 0.002 Identities = 49/200 (24%), Positives = 87/200 (43%), Gaps = 44/200 (22%) Query: 10 SGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIK 69 +G ++ +GLGTW + GQ+ + ++ +T+ Y + D A +Y E+ +G + Sbjct: 10 TGQKMPLIGLGTWKSEPGQVKAAI-KYALTVGYRH----IDCAAIYG---NELEIGEALT 61 Query: 70 ------KKGRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVF--- 120 K R L +T+K+ W K E + L+ +L LQLEY+D+ Sbjct: 62 ETVGPGKAVPREELFVTSKL-WNTKHHPE------DVEPALRKTLADLQLEYLDLYLMHW 114 Query: 121 ------ANRPDPN----------TPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYS 164 + P P T ++T +A+ ++ +G+ G S +SS +I + S Sbjct: 115 PYAFERGDNPFPKNADGTIRYDATHYKDTWKALEALVAKGLVRALGLSNFSSRQIDDVLS 174 Query: 165 VARQFNLIPPICEQAEYHMF 184 VA + P Q E H + Sbjct: 175 VAS----VRPAVLQVECHPY 190 >pdb|1CWN| Crystal Structure Of Porcine Aldehyde Reductase Holoenzyme Length = 324 Score = 38.0 bits (87), Expect = 0.002 Identities = 49/200 (24%), Positives = 87/200 (43%), Gaps = 44/200 (22%) Query: 10 SGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIK 69 +G ++ +GLGTW + GQ+ + ++ +T+ Y + D A +Y E+ +G + Sbjct: 9 TGQKMPLIGLGTWKSEPGQVKAAI-KYALTVGYRH----IDCAAIYG---NELEIGEALT 60 Query: 70 ------KKGRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVF--- 120 K R L +T+K+ W K E + L+ +L LQLEY+D+ Sbjct: 61 ETVGPGKAVPREELFVTSKL-WNTKHHPE------DVEPALRKTLADLQLEYLDLYLMHW 113 Query: 121 ------ANRPDPN----------TPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYS 164 + P P T ++T +A+ ++ +G+ G S +SS +I + S Sbjct: 114 PYAFERGDNPFPKNADGTIRYDATHYKDTWKALEALVAKGLVRALGLSNFSSRQIDDVLS 173 Query: 165 VARQFNLIPPICEQAEYHMF 184 VA + P Q E H + Sbjct: 174 VAS----VRPAVLQVECHPY 189 >pdb|2ALR| Aldehyde Reductase Length = 324 Score = 38.0 bits (87), Expect = 0.002 Identities = 50/200 (25%), Positives = 85/200 (42%), Gaps = 44/200 (22%) Query: 10 SGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIK 69 +G ++ +GLGTW + GQ+ + + A G D A +Y E +G +K Sbjct: 9 TGQKMPLIGLGTWKSEPGQV-----KAAVKYALSVGYRHIDCAAIYG---NEPEIGEALK 60 Query: 70 ------KKGRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANR 123 K R L +T+K+ W K E + L+ +L LQLEY+D+ + Sbjct: 61 EDVGPGKAVPREELFVTSKL-WNTKHHPE------DVEPALRKTLADLQLEYLDLYLMHW 113 Query: 124 P-------DP------------NTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYS 164 P +P +T +ET +A+ ++ +G+ G S ++S +I + S Sbjct: 114 PYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILS 173 Query: 165 VARQFNLIPPICEQAEYHMF 184 VA + P Q E H + Sbjct: 174 VAS----VRPAVLQVECHPY 189 >pdb|1HQT|A Chain A, The Crystal Structure Of An Aldehyde Reductase Y50f Mutant- Nadp Complex And Its Implications For Substrate Binding Length = 326 Score = 37.3 bits (85), Expect = 0.004 Identities = 48/200 (24%), Positives = 88/200 (44%), Gaps = 44/200 (22%) Query: 10 SGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIK 69 +G ++ +GLGTW + GQ+ + ++ +T+ Y + D A ++ E+ +G ++ Sbjct: 11 TGQKMPLIGLGTWKSEPGQVKAAI-KYALTVGYRH----IDCAAIFG---NELEIGEALQ 62 Query: 70 ------KKGRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVF--- 120 K R L +T+K+ W K E + L+ +L LQLEY+D+ Sbjct: 63 ETVGPGKAVPREELFVTSKL-WNTKHHPE------DVEPALRKTLADLQLEYLDLYLMHW 115 Query: 121 ------ANRPDPN----------TPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYS 164 + P P T ++T +A+ ++ +G+ G S +SS +I + S Sbjct: 116 PYAFERGDNPFPKNADGTIRYDATHYKDTWKALEALVAKGLVRALGLSNFSSRQIDDVLS 175 Query: 165 VARQFNLIPPICEQAEYHMF 184 VA + P Q E H + Sbjct: 176 VAS----VRPAVLQVECHPY 191 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: pdb|1EXB|A Chain A, Structure Of The Cytoplasmic Beta Subunit-T1... 562 e-161 pdb|1QRQ|A Chain A, Structure Of A Voltage-Dependent K+ Channel ... 560 e-160 pdb|1GVE|A Chain A, Aflatoxin Aldehyde Reductase (Akr7a1) From R... 416 e-117 pdb|1GVE|B Chain B, Aflatoxin Aldehyde Reductase (Akr7a1) From R... 413 e-116 pdb|2ALR| Aldehyde Reductase 240 4e-64 pdb|1AE4| Aldehyde Reductase Complexed With Cofactor And Inhib... 238 9e-64 pdb|1CWN| Crystal Structure Of Porcine Aldehyde Reductase Holo... 238 9e-64 pdb|1HQT|A Chain A, The Crystal Structure Of An Aldehyde Reducta... 235 6e-63 Sequences not found previously or not previously below threshold: pdb|2ACQ| Aldose Reductase (E.C.1.1.1.21) Wild Type Complexed ... 122 9e-29 pdb|1AZ1| Alrestatin Bound To C298aW219Y MUTANT HUMAN ALDOSE R... 122 9e-29 pdb|1EL3|A Chain A, Human Aldose Reductase Complexed With Idd384... 122 9e-29 pdb|1ABN| Aldose Reductase (E.C.1.1.1.21) Mutant With Cys 298 ... 122 1e-28 pdb|2ACU| Aldose Reductase (E.C.1.1.1.21) Mutant With Tyr 48 R... 120 5e-28 pdb|1C9W|A Chain A, Cho Reductase With Nadp+ 114 2e-26 pdb|1J96|A Chain A, Human 3alpha-Hsd Type 3 In Ternary Complex W... 113 4e-26 pdb|1IHI|A Chain A, Crystal Structure Of Human Type Iii 3-Alpha-... 113 4e-26 pdb|1AH4| Pig Aldose Reductase, Holo Form >gi|8569627|pdb|1EKO... 113 6e-26 pdb|1DLA|B Chain B, Aldose Reductase (E.C.1.1.1.21) >gi|515112|p... 113 6e-26 pdb|1AH0| Pig Aldose Reductase Complexed With Sorbinil 113 6e-26 pdb|1FRB| Fr-1 ProteinNADPHZOPOLRESTAT COMPLEX 109 6e-25 pdb|1LWI|A Chain A, 3-Alpha-HydroxysteroidDIHYDRODIOL DEHYDROGEN... 106 5e-24 pdb|1AFS|A Chain A, Recombinant Rat Liver 3-Alpha-Hydroxysteroid... 106 5e-24 pdb|1RAL| 3-Alpha-Hydroxysteroid Dehydrogenase (E.C.1.1.1.50) 106 5e-24 pdb|1A80| Native 2,5-Diketo-D-Gluconic Acid Reductase A From C... 88 2e-18 pdb|1HW6|A Chain A, Crystal Structure Of Apo-2,5-Diketo-D-Glucon... 88 2e-18 >pdb|1EXB|A Chain A, Structure Of The Cytoplasmic Beta Subunit-T1 Assembly Of Voltage-Dependent K Channels Length = 332 Score = 562 bits (1433), Expect = e-161 Identities = 324/326 (99%), Positives = 324/326 (99%), Gaps = 2/326 (0%) Query: 1 LQFYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKA 60 LQFYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKA Sbjct: 1 LQFYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKA 60 Query: 61 EVVLGNIIKKKG-RRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVV 119 EVVLGNIIKKKG RRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVV Sbjct: 61 EVVLGNIIKKKGWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVV 120 Query: 120 FANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLIPPICEQA 179 FANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLIPPICEQA Sbjct: 121 FANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLIPPICEQA 180 Query: 180 EYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKD 239 EYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKD Sbjct: 181 EYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKD 240 Query: 240 KILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNAEQLMENIG 299 KILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNAEQLMENIG Sbjct: 241 KILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNAEQLMENIG 300 Query: 300 AIQVLPKLSSSIVHEIDSILG-KPYS 324 AIQVLPKLSSSIVHEIDSILG KPYS Sbjct: 301 AIQVLPKLSSSIVHEIDSILGNKPYS 326 >pdb|1QRQ|A Chain A, Structure Of A Voltage-Dependent K+ Channel Beta Subunit pdb|1QRQ|B Chain B, Structure Of A Voltage-Dependent K+ Channel Beta Subunit pdb|1QRQ|C Chain C, Structure Of A Voltage-Dependent K+ Channel Beta Subunit pdb|1QRQ|D Chain D, Structure Of A Voltage-Dependent K+ Channel Beta Subunit Length = 325 Score = 560 bits (1428), Expect = e-160 Identities = 323/325 (99%), Positives = 323/325 (99%), Gaps = 2/325 (0%) Query: 1 LQFYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKA 60 LQFYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKA Sbjct: 1 LQFYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKA 60 Query: 61 EVVLGNIIKKKG-RRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVV 119 EVVLGNIIKKKG RRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVV Sbjct: 61 EVVLGNIIKKKGWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVV 120 Query: 120 FANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLIPPICEQA 179 FANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLIPPICEQA Sbjct: 121 FANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLIPPICEQA 180 Query: 180 EYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKD 239 EYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKD Sbjct: 181 EYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKD 240 Query: 240 KILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNAEQLMENIG 299 KILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNAEQLMENIG Sbjct: 241 KILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNAEQLMENIG 300 Query: 300 AIQVLPKLSSSIVHEIDSILG-KPY 323 AIQVLPKLSSSIVHEIDSILG KPY Sbjct: 301 AIQVLPKLSSSIVHEIDSILGNKPY 325 >pdb|1GVE|A Chain A, Aflatoxin Aldehyde Reductase (Akr7a1) From Rat Liver Length = 327 Score = 416 bits (1060), Expect = e-117 Identities = 82/285 (28%), Positives = 134/285 (46%), Gaps = 20/285 (7%) Query: 45 GINLFDTAEVYAAGKAEVVLGNIIKKKGRRSSLVITTKIFWGGKAETERGLSRKHIIEGL 104 G DTA VYA G++E +LG++ GR V KI + L + L Sbjct: 35 GHTEIDTAFVYANGQSETILGDLGLGLGRSGCKV---KIATKAAPMFGKTLKPADVRFQL 91 Query: 105 KASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYS 164 + SL+RLQ VD+ + + PD TP+EET++A + +G + G S + S E+ E + Sbjct: 92 ETSLKRLQCPRVDLFYLHFPDHGTPIEETLQACHQLHQEGKFVELGLSNYVSWEVAEICT 151 Query: 165 VARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKY----D 220 + ++ I P Q Y+ R+ VE +L G+ ++PLA G+++G+Y Sbjct: 152 LCKKNGWIMPTVYQGMYNAITRQ-VETELFPCLRHFGLRFYAFNPLAGGLLTGRYKYQDK 210 Query: 221 SGIPPYSRASLKGY-QWLKDKILSEEGRRQQAKLKELQAIAERLGCTLPQL---AIAWC- 275 G P SR + Q D+ EE A ++ +A+ G T P + A+ W Sbjct: 211 DGKNPESRFFGNPFSQLYMDRYWKEEHFNGIALVE--KALKTTYGPTAPSMISAAVRWMY 268 Query: 276 ----LRNEGVSSVLLGASNAEQLMENIGAIQVLPKLSSSIVHEID 316 L+ +V+LG S+ EQL +N+ ++ P L ++V D Sbjct: 269 HHSQLKGTQGDAVILGMSSLEQLEQNLALVEEGP-LEPAVVDAFD 312 >pdb|1GVE|B Chain B, Aflatoxin Aldehyde Reductase (Akr7a1) From Rat Liver Length = 327 Score = 413 bits (1052), Expect = e-116 Identities = 82/285 (28%), Positives = 134/285 (46%), Gaps = 20/285 (7%) Query: 45 GINLFDTAEVYAAGKAEVVLGNIIKKKGRRSSLVITTKIFWGGKAETERGLSRKHIIEGL 104 G DTA VYA G++E +LG++ GR V KI + L + L Sbjct: 35 GHTEIDTAFVYANGQSETILGDLGLGLGRSGCKV---KIATKAAPMFGKTLKPADVRFQL 91 Query: 105 KASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYS 164 + SL+RLQ VD+ + + PD TP+EET++A + +G + G S + S E+ E + Sbjct: 92 ETSLKRLQCPRVDLFYLHFPDHGTPIEETLQACHQLHQEGKFVELGLSNYVSWEVAEICT 151 Query: 165 VARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKY----D 220 + ++ I P Q Y+ R+ VE +L G+ ++PLA G+++G+Y Sbjct: 152 LCKKNGWIMPTVYQGMYNAITRQ-VETELFPCLRHFGLRFYAFNPLAGGLLTGRYKYQDK 210 Query: 221 SGIPPYSRASLKGY-QWLKDKILSEEGRRQQAKLKELQAIAERLGCTLPQL---AIAWC- 275 G P SR + Q D+ EE A ++ +A+ G T P + A+ W Sbjct: 211 DGKNPESRFFGNPFSQLYMDRDWKEEHFNGIALVE--KALKTTYGPTAPSMISAAVRWMY 268 Query: 276 ----LRNEGVSSVLLGASNAEQLMENIGAIQVLPKLSSSIVHEID 316 L+ +V+LG S+ EQL +N+ ++ P L ++V D Sbjct: 269 HHSQLKGTQGDAVILGMSSLEQLEQNLALVEEGP-LEPAVVDAFD 312 >pdb|2ALR| Aldehyde Reductase Length = 324 Score = 240 bits (606), Expect = 4e-64 Identities = 64/292 (21%), Positives = 113/292 (37%), Gaps = 76/292 (26%) Query: 10 SGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIK 69 +G ++ +GLGTW + GQ+ + + A G D A +Y E +G +K Sbjct: 9 TGQKMPLIGLGTWKSEPGQV-----KAAVKYALSVGYRHIDCAAIYG---NEPEIGEALK 60 Query: 70 ------KKGRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANR 123 K R L +T+K+ W K E + L+ +L LQLEY+D+ + Sbjct: 61 EDVGPGKAVPREELFVTSKL-WNTKHHPE------DVEPALRKTLADLQLEYLDLYLMHW 113 Query: 124 P-------DP------------NTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYS 164 P +P +T +ET +A+ ++ +G+ G S ++S +I + S Sbjct: 114 PYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILS 173 Query: 165 VARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIP 224 VA + P Q E H + + +L G+ +SPL Sbjct: 174 VAS----VRPAVLQVECHPYLAQN---ELIAHCQARGLEVTAYSPLGSS----------- 215 Query: 225 PYSRASLKGYQWLKDKILSEEGRRQQAKLKE--LQAIAERLGCTLPQLAIAW 274 D+ + + L+E + A+AE+ G + Q+ + W Sbjct: 216 --------------DRAWRDP--DEPVLLEEPVVLALAEKYGRSPAQILLRW 251 >pdb|1AE4| Aldehyde Reductase Complexed With Cofactor And Inhibitor, Alpha Carbon Atoms Only Length = 325 Score = 238 bits (603), Expect = 9e-64 Identities = 63/292 (21%), Positives = 111/292 (37%), Gaps = 76/292 (26%) Query: 10 SGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIK 69 +G ++ +GLGTW + GQ+ + + A G D A +Y E+ +G + Sbjct: 10 TGQKMPLIGLGTWKSEPGQV-----KAAIKYALTVGYRHIDCAAIYG---NELEIGEALT 61 Query: 70 ------KKGRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANR 123 K R L +T+K+ W K E + L+ +L LQLEY+D+ + Sbjct: 62 ETVGPGKAVPREELFVTSKL-WNTKHHPE------DVEPALRKTLADLQLEYLDLYLMHW 114 Query: 124 ---------PDPN----------TPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYS 164 P P T ++T +A+ ++ +G+ G S +SS +I + S Sbjct: 115 PYAFERGDNPFPKNADGTIRYDATHYKDTWKALEALVAKGLVRALGLSNFSSRQIDDVLS 174 Query: 165 VARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIP 224 VA + P Q E H + + +L G+ +SPL Sbjct: 175 VAS----VRPAVLQVECHPYLAQN---ELIAHCQARGLEVTAYSPLGSS----------- 216 Query: 225 PYSRASLKGYQWLKDKILSEEGRRQQAKLKE--LQAIAERLGCTLPQLAIAW 274 D+ + + L+E +QA+AE+ + Q+ + W Sbjct: 217 --------------DRAWRDP--NEPVLLEEPVVQALAEKYNRSPAQILLRW 252 >pdb|1CWN| Crystal Structure Of Porcine Aldehyde Reductase Holoenzyme Length = 324 Score = 238 bits (603), Expect = 9e-64 Identities = 63/292 (21%), Positives = 111/292 (37%), Gaps = 76/292 (26%) Query: 10 SGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIK 69 +G ++ +GLGTW + GQ+ + + A G D A +Y E+ +G + Sbjct: 9 TGQKMPLIGLGTWKSEPGQV-----KAAIKYALTVGYRHIDCAAIYG---NELEIGEALT 60 Query: 70 ------KKGRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANR 123 K R L +T+K+ W K E + L+ +L LQLEY+D+ + Sbjct: 61 ETVGPGKAVPREELFVTSKL-WNTKHHPE------DVEPALRKTLADLQLEYLDLYLMHW 113 Query: 124 ---------PDPN----------TPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYS 164 P P T ++T +A+ ++ +G+ G S +SS +I + S Sbjct: 114 PYAFERGDNPFPKNADGTIRYDATHYKDTWKALEALVAKGLVRALGLSNFSSRQIDDVLS 173 Query: 165 VARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIP 224 VA + P Q E H + + +L G+ +SPL Sbjct: 174 VAS----VRPAVLQVECHPYLAQN---ELIAHCQARGLEVTAYSPLGSS----------- 215 Query: 225 PYSRASLKGYQWLKDKILSEEGRRQQAKLKE--LQAIAERLGCTLPQLAIAW 274 D+ + + L+E +QA+AE+ + Q+ + W Sbjct: 216 --------------DRAWRDP--NEPVLLEEPVVQALAEKYNRSPAQILLRW 251 >pdb|1HQT|A Chain A, The Crystal Structure Of An Aldehyde Reductase Y50f Mutant- Nadp Complex And Its Implications For Substrate Binding Length = 326 Score = 235 bits (595), Expect = 6e-63 Identities = 62/292 (21%), Positives = 112/292 (38%), Gaps = 76/292 (26%) Query: 10 SGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIK 69 +G ++ +GLGTW + GQ+ + + A G D A ++ E+ +G ++ Sbjct: 11 TGQKMPLIGLGTWKSEPGQV-----KAAIKYALTVGYRHIDCAAIFG---NELEIGEALQ 62 Query: 70 ------KKGRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANR 123 K R L +T+K+ W K E + L+ +L LQLEY+D+ + Sbjct: 63 ETVGPGKAVPREELFVTSKL-WNTKHHPE------DVEPALRKTLADLQLEYLDLYLMHW 115 Query: 124 ---------PDPN----------TPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYS 164 P P T ++T +A+ ++ +G+ G S +SS +I + S Sbjct: 116 PYAFERGDNPFPKNADGTIRYDATHYKDTWKALEALVAKGLVRALGLSNFSSRQIDDVLS 175 Query: 165 VARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIP 224 VA + P Q E H + + +L G+ +SPL Sbjct: 176 VAS----VRPAVLQVECHPYLAQN---ELIAHCQARGLEVTAYSPLGSS----------- 217 Query: 225 PYSRASLKGYQWLKDKILSEEGRRQQAKLKE--LQAIAERLGCTLPQLAIAW 274 D+ + + L+E +QA+AE+ + Q+ + W Sbjct: 218 --------------DRAWRDP--NEPVLLEEPVVQALAEKYNRSPAQILLRW 253 >pdb|2ACQ| Aldose Reductase (E.C.1.1.1.21) Wild Type Complexed With Nadp+ And Glucose-6-Phosphate pdb|2ACR| Aldose Reductase (E.C.1.1.1.21) Wild Type Complexed With Nadp+ And Cacodylate pdb|1ADS| Aldose Reductase (E.C.1.1.1.21) Complex With Nadph pdb|1EF3|A Chain A, Fidarestat Bound To Human Aldose Reductase pdb|1EF3|B Chain B, Fidarestat Bound To Human Aldose Reductase pdb|2ACS| Aldose Reductase (E.C.1.1.1.21) Wild Type Complexed With Nadp+ And Citrate pdb|1MAR| Aldose Reductase (E.C.1.1.1.21) Length = 315 Score = 122 bits (304), Expect = 9e-29 Identities = 55/230 (23%), Positives = 100/230 (42%), Gaps = 44/230 (19%) Query: 5 RNLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVL 64 R L +G ++ LGLGTW + GQ+T+ + +A D G D A VY + E + Sbjct: 3 RLLLNNGAKMPILGLGTWKSPPGQVTE-----AVKVAIDVGYRHIDCAHVY---QNENEV 54 Query: 65 GNIIKKKGR-----RSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVV 119 G I++K R R L I +K+ W E+GL + + +L L+L+Y+D+ Sbjct: 55 GVAIQEKLREQVVKREELFIVSKL-WCTYH--EKGL----VKGACQKTLSDLKLDYLDLY 107 Query: 120 FANRP---------DP----------NTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIM 160 + P P +T + +T AM ++++G+ G S ++ +++ Sbjct: 108 LIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVE 167 Query: 161 EAYSVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPL 210 + + P Q E H + ++ +L + G+ +SPL Sbjct: 168 MILN--KPGLKYKPAVNQIECHPYLTQE---KLIQYCQSKGIVVTAYSPL 212 >pdb|1AZ1| Alrestatin Bound To C298aW219Y MUTANT HUMAN ALDOSE Reductase pdb|1AZ2| Citrate Bound, C298aW219Y MUTANT HUMAN ALDOSE REDUCTASE Length = 315 Score = 122 bits (304), Expect = 9e-29 Identities = 55/230 (23%), Positives = 100/230 (42%), Gaps = 44/230 (19%) Query: 5 RNLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVL 64 R L +G ++ LGLGTW + GQ+T+ + +A D G D A VY + E + Sbjct: 3 RLLLNNGAKMPILGLGTWKSPPGQVTE-----AVKVAIDVGYRHIDCAHVY---QNENEV 54 Query: 65 GNIIKKKGR-----RSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVV 119 G I++K R R L I +K+ W E+GL + + +L L+L+Y+D+ Sbjct: 55 GVAIQEKLREQVVKREELFIVSKL-WCTYH--EKGL----VKGACQKTLSDLKLDYLDLY 107 Query: 120 FANRP---------DP----------NTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIM 160 + P P +T + +T AM ++++G+ G S ++ +++ Sbjct: 108 LIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVE 167 Query: 161 EAYSVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPL 210 + + P Q E H + ++ +L + G+ +SPL Sbjct: 168 MILN--KPGLKYKPAVNQIECHPYLTQE---KLIQYCQSKGIVVTAYSPL 212 >pdb|1EL3|A Chain A, Human Aldose Reductase Complexed With Idd384 Inhibitor pdb|1IEI|A Chain A, Crystal Structure Of Human Aldose Reductase Complexed With The Inhibitor Zenarestat Length = 316 Score = 122 bits (304), Expect = 9e-29 Identities = 55/230 (23%), Positives = 100/230 (42%), Gaps = 44/230 (19%) Query: 5 RNLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVL 64 R L +G ++ LGLGTW + GQ+T+ + +A D G D A VY + E + Sbjct: 4 RLLLNNGAKMPILGLGTWKSPPGQVTE-----AVKVAIDVGYRHIDCAHVY---QNENEV 55 Query: 65 GNIIKKKGR-----RSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVV 119 G I++K R R L I +K+ W E+GL + + +L L+L+Y+D+ Sbjct: 56 GVAIQEKLREQVVKREELFIVSKL-WCTYH--EKGL----VKGACQKTLSDLKLDYLDLY 108 Query: 120 FANRP---------DP----------NTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIM 160 + P P +T + +T AM ++++G+ G S ++ +++ Sbjct: 109 LIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVE 168 Query: 161 EAYSVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPL 210 + + P Q E H + ++ +L + G+ +SPL Sbjct: 169 MILN--KPGLKYKPAVNQIECHPYLTQE---KLIQYCQSKGIVVTAYSPL 213 >pdb|1ABN| Aldose Reductase (E.C.1.1.1.21) Mutant With Cys 298 Replaced By Ser (C298s) Complex With Nadph Length = 315 Score = 122 bits (304), Expect = 1e-28 Identities = 55/230 (23%), Positives = 100/230 (42%), Gaps = 44/230 (19%) Query: 5 RNLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVL 64 R L +G ++ LGLGTW + GQ+T+ + +A D G D A VY + E + Sbjct: 3 RLLLNNGAKMPILGLGTWKSPPGQVTE-----AVKVAIDVGYRHIDCAHVY---QNENEV 54 Query: 65 GNIIKKKGR-----RSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVV 119 G I++K R R L I +K+ W E+GL + + +L L+L+Y+D+ Sbjct: 55 GVAIQEKLREQVVKREELFIVSKL-WCTYH--EKGL----VKGACQKTLSDLKLDYLDLY 107 Query: 120 FANRP---------DP----------NTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIM 160 + P P +T + +T AM ++++G+ G S ++ +++ Sbjct: 108 LIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVE 167 Query: 161 EAYSVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPL 210 + + P Q E H + ++ +L + G+ +SPL Sbjct: 168 MILN--KPGLKYKPAVNQIECHPYLTQE---KLIQYCQSKGIVVTAYSPL 212 >pdb|2ACU| Aldose Reductase (E.C.1.1.1.21) Mutant With Tyr 48 Replaced By His (Y48h) Complexed With Nadp+ And Citrate Length = 315 Score = 120 bits (298), Expect = 5e-28 Identities = 54/230 (23%), Positives = 100/230 (43%), Gaps = 44/230 (19%) Query: 5 RNLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVL 64 R L +G ++ LGLGTW + GQ+T+ + +A D G D A V+ + E + Sbjct: 3 RLLLNNGAKMPILGLGTWKSPPGQVTE-----AVKVAIDVGYRHIDCAHVH---QNENEV 54 Query: 65 GNIIKKKGR-----RSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVV 119 G I++K R R L I +K+ W E+GL + + +L L+L+Y+D+ Sbjct: 55 GVAIQEKLREQVVKREELFIVSKL-WCTYH--EKGL----VKGACQKTLSDLKLDYLDLY 107 Query: 120 FANRP---------DP----------NTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIM 160 + P P +T + +T AM ++++G+ G S ++ +++ Sbjct: 108 LIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVE 167 Query: 161 EAYSVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPL 210 + + P Q E H + ++ +L + G+ +SPL Sbjct: 168 MILN--KPGLKYKPAVNQIECHPYLTQE---KLIQYCQSKGIVVTAYSPL 212 >pdb|1C9W|A Chain A, Cho Reductase With Nadp+ Length = 315 Score = 114 bits (284), Expect = 2e-26 Identities = 51/225 (22%), Positives = 90/225 (39%), Gaps = 44/225 (19%) Query: 10 SGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIK 69 + ++ +GLGTW + GQ+ + + +A D G D A Y E +G I+ Sbjct: 8 TKAKMPIVGLGTWQSPPGQV-----KEAVKVAIDAGYRHIDCAYAY---YNEHEVGEAIQ 59 Query: 70 -----KKGRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRP 124 K RR L I +K+ W ER L + E + +L L+L+Y+D+ + P Sbjct: 60 EKIKEKAVRREDLFIVSKL-WPTC--FERKL----LKEAFQKTLTDLKLDYLDLYLIHWP 112 Query: 125 DPNTPMEE-------------------TVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSV 165 P +E M ++++G+ G S ++ +I + Sbjct: 113 QGLQPGKELFPKDDQGNVLTSKITFLDAWEVMEELVDEGLVKALGVSNFNHFQIERILN- 171 Query: 166 ARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPL 210 + P+ Q E H + ++ +L E H G+ +SPL Sbjct: 172 -KPGLKHKPVTNQVECHPYLTQE---KLIEYCHSKGITVTAYSPL 212 >pdb|1J96|A Chain A, Human 3alpha-Hsd Type 3 In Ternary Complex With Nadp And Testosterone pdb|1J96|B Chain B, Human 3alpha-Hsd Type 3 In Ternary Complex With Nadp And Testosterone Length = 323 Score = 113 bits (282), Expect = 4e-26 Identities = 46/202 (22%), Positives = 77/202 (37%), Gaps = 38/202 (18%) Query: 11 GLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIK- 69 G + LG GT+ ++ A + LA + G + D+A VY E +G I+ Sbjct: 13 GHFMPVLGFGTYA--PAEVPKSKALEAVKLAIEAGFHHIDSAHVY---NNEEQVGLAIRS 67 Query: 70 ----KKGRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPD 125 +R + T+K+ W E + L+ SL+ LQL+YVD+ + P Sbjct: 68 KIADGSVKREDIFYTSKL-WSNSHRPEL------VRPALERSLKNLQLDYVDLYLIHFPV 120 Query: 126 PNTPMEE-------------------TVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVA 166 P EE T AM + G+A G S ++ + + Sbjct: 121 SVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILN-- 178 Query: 167 RQFNLIPPICEQAEYHMFQREK 188 + P+C Q E H + ++ Sbjct: 179 KPGLKYKPVCNQVECHPYFNQR 200 >pdb|1IHI|A Chain A, Crystal Structure Of Human Type Iii 3-Alpha-Hydroxysteroid DehydrogenaseBILE ACID BINDING PROTEIN (AKR1C2) COMPLEXED With Nadp+ And Ursodeoxycholate pdb|1IHI|B Chain B, Crystal Structure Of Human Type Iii 3-Alpha-Hydroxysteroid DehydrogenaseBILE ACID BINDING PROTEIN (AKR1C2) COMPLEXED With Nadp+ And Ursodeoxycholate Length = 323 Score = 113 bits (281), Expect = 4e-26 Identities = 46/202 (22%), Positives = 77/202 (37%), Gaps = 38/202 (18%) Query: 11 GLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIK- 69 G + LG GT+ ++ A + LA + G + D+A VY E +G I+ Sbjct: 13 GHFMPVLGFGTYA--PAEVPKSKALEAVKLAIEAGFHHIDSAHVY---NNEEQVGLAIRS 67 Query: 70 ----KKGRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPD 125 +R + T+K+ W E + L+ SL+ LQL+YVD+ + P Sbjct: 68 KIADGSVKREDIFYTSKL-WSNSHRPEL------VRPALERSLKNLQLDYVDLYLIHFPV 120 Query: 126 PNTPMEE-------------------TVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVA 166 P EE T AM + G+A G S ++ + + Sbjct: 121 SVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILN-- 178 Query: 167 RQFNLIPPICEQAEYHMFQREK 188 + P+C Q E H + ++ Sbjct: 179 KPGLKYKPVCNQVECHPYFNQR 200 >pdb|1AH4| Pig Aldose Reductase, Holo Form pdb|1EKO|A Chain A, Pig Aldose Reductase Complexed With Idd384 Inhibitor pdb|1AH3| Aldose Reductase Complexed With Tolrestat Inhibitor Length = 315 Score = 113 bits (280), Expect = 6e-26 Identities = 52/223 (23%), Positives = 96/223 (42%), Gaps = 40/223 (17%) Query: 10 SGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLG---N 66 +G ++ LGLGTW + G++T+ + +A D G D A VY + EV LG Sbjct: 8 TGAKMPILGLGTWKSPPGKVTE-----AVKVAIDLGYRHIDCAHVYQN-ENEVGLGLQEK 61 Query: 67 IIKKKGRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRP-- 124 + + +R L I +K+ W E+ L + + +L L+L+Y+D+ + P Sbjct: 62 LQGQVVKREDLFIVSKL-WCTDH--EKNL----VKGACQTTLRDLKLDYLDLYLIHWPTG 114 Query: 125 -----DP------------NTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVAR 167 DP + ET AM ++++G+ G S ++ +++ + + + Sbjct: 115 FKPGKDPFPLDGDGNVVPDESDFVETWEAMEELVDEGLVKAIGVSNFNHLQVEKILN--K 172 Query: 168 QFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPL 210 P Q E H + ++ +L E G+ +SPL Sbjct: 173 PGLKYKPAVNQIEVHPYLTQE---KLIEYCKSKGIVVTAYSPL 212 >pdb|1DLA|B Chain B, Aldose Reductase (E.C.1.1.1.21) pdb|1DLA|C Chain C, Aldose Reductase (E.C.1.1.1.21) pdb|1DLA|A Chain A, Aldose Reductase (E.C.1.1.1.21) pdb|1DLA|D Chain D, Aldose Reductase (E.C.1.1.1.21) Length = 314 Score = 113 bits (280), Expect = 6e-26 Identities = 52/223 (23%), Positives = 96/223 (42%), Gaps = 40/223 (17%) Query: 10 SGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLG---N 66 +G ++ LGLGTW + G++T+ + +A D G D A VY + EV LG Sbjct: 7 TGAKMPILGLGTWKSPPGKVTE-----AVKVAIDLGYRHIDCAHVYQN-ENEVGLGLQEK 60 Query: 67 IIKKKGRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRP-- 124 + + +R L I +K+ W E+ L + + +L L+L+Y+D+ + P Sbjct: 61 LQGQVVKREDLFIVSKL-WCTDH--EKNL----VKGACQTTLRDLKLDYLDLYLIHWPTG 113 Query: 125 -----DP------------NTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVAR 167 DP + ET AM ++++G+ G S ++ +++ + + + Sbjct: 114 FKPGKDPFPLDGDGNVVPDESDFVETWEAMEELVDEGLVKAIGVSNFNHLQVEKILN--K 171 Query: 168 QFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPL 210 P Q E H + ++ +L E G+ +SPL Sbjct: 172 PGLKYKPAVNQIEVHPYLTQE---KLIEYCKSKGIVVTAYSPL 211 >pdb|1AH0| Pig Aldose Reductase Complexed With Sorbinil Length = 316 Score = 113 bits (280), Expect = 6e-26 Identities = 52/223 (23%), Positives = 96/223 (42%), Gaps = 40/223 (17%) Query: 10 SGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLG---N 66 +G ++ LGLGTW + G++T+ + +A D G D A VY + EV LG Sbjct: 9 TGAKMPILGLGTWKSPPGKVTE-----AVKVAIDLGYRHIDCAHVYQN-ENEVGLGLQEK 62 Query: 67 IIKKKGRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRP-- 124 + + +R L I +K+ W E+ L + + +L L+L+Y+D+ + P Sbjct: 63 LQGQVVKREDLFIVSKL-WCTDH--EKNL----VKGACQTTLRDLKLDYLDLYLIHWPTG 115 Query: 125 -----DP------------NTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVAR 167 DP + ET AM ++++G+ G S ++ +++ + + + Sbjct: 116 FKPGKDPFPLDGDGNVVPDESDFVETWEAMEELVDEGLVKAIGVSNFNHLQVEKILN--K 173 Query: 168 QFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPL 210 P Q E H + ++ +L E G+ +SPL Sbjct: 174 PGLKYKPAVNQIEVHPYLTQE---KLIEYCKSKGIVVTAYSPL 213 >pdb|1FRB| Fr-1 ProteinNADPHZOPOLRESTAT COMPLEX Length = 315 Score = 109 bits (271), Expect = 6e-25 Identities = 49/225 (21%), Positives = 88/225 (38%), Gaps = 44/225 (19%) Query: 10 SGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIK 69 + ++ +GLGTW + Q+ + + A D G D A Y E +G I+ Sbjct: 8 TKAKMPIVGLGTWKSPPNQV-----KEAVKAAIDAGYRHIDCAYAYC---NENEVGEAIQ 59 Query: 70 -----KKGRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRP 124 K +R L I +K+ W E+ L + E + +L L+L+Y+D+ + P Sbjct: 60 EKIKEKAVQREDLFIVSKL-WPTC--FEKKL----LKEAFQKTLTDLKLDYLDLYLIHWP 112 Query: 125 ---------DP----------NTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSV 165 P T E M +++QG+ G S ++ +I + Sbjct: 113 QGLQPGKELFPKDDQGRILTSKTTFLEAWEGMEELVDQGLVKALGVSNFNHFQIERLLN- 171 Query: 166 ARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPL 210 + P+ Q E H + ++ +L + H G+ +SPL Sbjct: 172 -KPGLKHKPVTNQVECHPYLTQE---KLIQYCHSKGISVTAYSPL 212 >pdb|1LWI|A Chain A, 3-Alpha-HydroxysteroidDIHYDRODIOL DEHYDROGENASE FROM Rattus Norvegicus pdb|1LWI|B Chain B, 3-Alpha-HydroxysteroidDIHYDRODIOL DEHYDROGENASE FROM Rattus Norvegicus Length = 322 Score = 106 bits (264), Expect = 5e-24 Identities = 42/201 (20%), Positives = 77/201 (37%), Gaps = 38/201 (18%) Query: 11 GLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIK- 69 G + LG GT T ++ + +A DNG FD+A +Y + E +G I+ Sbjct: 13 GNFIPVLGFGT--TVPEKVAKDEVIKATKIAIDNGFRHFDSAYLY---EVEEEVGQAIRS 67 Query: 70 ----KKGRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRP- 124 +R + T+K+ W E + L+ +L+ QL+YVD+ + P Sbjct: 68 KIEDGTVKREDIFYTSKL-WSTFHRPEL------VRTCLEKTLKSTQLDYVDLYIIHFPM 120 Query: 125 ------------------DPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVA 166 + +T AM + G+A G S ++ ++ + Sbjct: 121 ALQPGDIFFPRDEHGKLLFETVDICDTWEAMEKCKDAGLAKSIGVSNFNCRQLERILN-- 178 Query: 167 RQFNLIPPICEQAEYHMFQRE 187 + P+C Q E H++ + Sbjct: 179 KPGLKYKPVCNQVECHLYLNQ 199 >pdb|1AFS|A Chain A, Recombinant Rat Liver 3-Alpha-Hydroxysteroid Dehydrogenase (3-Alpha-Hsd) Complexed With Nadp And Testosterone pdb|1AFS|B Chain B, Recombinant Rat Liver 3-Alpha-Hydroxysteroid Dehydrogenase (3-Alpha-Hsd) Complexed With Nadp And Testosterone Length = 323 Score = 106 bits (264), Expect = 5e-24 Identities = 42/201 (20%), Positives = 77/201 (37%), Gaps = 38/201 (18%) Query: 11 GLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIK- 69 G + LG GT T ++ + +A DNG FD+A +Y + E +G I+ Sbjct: 13 GNFIPVLGFGT--TVPEKVAKDEVIKATKIAIDNGFRHFDSAYLY---EVEEEVGQAIRS 67 Query: 70 ----KKGRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRP- 124 +R + T+K+ W E + L+ +L+ QL+YVD+ + P Sbjct: 68 KIEDGTVKREDIFYTSKL-WSTFHRPEL------VRTCLEKTLKSTQLDYVDLYIIHFPM 120 Query: 125 ------------------DPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVA 166 + +T AM + G+A G S ++ ++ + Sbjct: 121 ALQPGDIFFPRDEHGKLLFETVDICDTWEAMEKCKDAGLAKSIGVSNFNCRQLERILN-- 178 Query: 167 RQFNLIPPICEQAEYHMFQRE 187 + P+C Q E H++ + Sbjct: 179 KPGLKYKPVCNQVECHLYLNQ 199 >pdb|1RAL| 3-Alpha-Hydroxysteroid Dehydrogenase (E.C.1.1.1.50) Length = 308 Score = 106 bits (264), Expect = 5e-24 Identities = 42/201 (20%), Positives = 77/201 (37%), Gaps = 38/201 (18%) Query: 11 GLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIK- 69 G + LG GT T ++ + +A DNG FD+A +Y + E +G I+ Sbjct: 13 GNFIPVLGFGT--TVPEKVAKDEVIKATKIAIDNGFRHFDSAYLY---EVEEEVGQAIRS 67 Query: 70 ----KKGRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRP- 124 +R + T+K+ W E + L+ +L+ QL+YVD+ + P Sbjct: 68 KIEDGTVKREDIFYTSKL-WSTFHRPEL------VRTCLEKTLKSTQLDYVDLYIIHFPM 120 Query: 125 ------------------DPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVA 166 + +T AM + G+A G S ++ ++ + Sbjct: 121 ALQPGDIFFPRDEHGKLLFETVDICDTWEAMEKCKDAGLAKSIGVSNFNCRQLERILN-- 178 Query: 167 RQFNLIPPICEQAEYHMFQRE 187 + P+C Q E H++ + Sbjct: 179 KPGLKYKPVCNQVECHLYLNQ 199 >pdb|1A80| Native 2,5-Diketo-D-Gluconic Acid Reductase A From Corynbacterium Sp. Complexed With Nadph Length = 277 Score = 88.1 bits (216), Expect = 2e-18 Identities = 60/308 (19%), Positives = 94/308 (30%), Gaps = 58/308 (18%) Query: 11 GLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKK 70 G + LG G + + E A + G DTA +Y E V I Sbjct: 10 GNSIPQLGYGVFKVPPADTQRAVEE-----ALEVGYRHIDTAAIYGN--EEGVGAAIAAS 62 Query: 71 KGRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNT-P 129 R L ITTK+ W + G + SL +L L+ VD+ + P P Sbjct: 63 GIARDDLFITTKL-WNDRH---DGDEPA---AAIAESLAKLALDQVDLYLVHWPTPAADN 115 Query: 130 MEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLIPPICEQAEYHMFQREKV 189 M + G+ G S + + + P Q E H +++ Sbjct: 116 YVHAWEKMIELRAAGLTRSIGVSNHLVPHLERIVAA----TGVVPAVNQIELHPAYQQR- 170 Query: 190 EVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKDKILSEEGRRQ 249 ++ + V +W PL GKYD Sbjct: 171 --EITDWAAAHDVKIESWGPLG----QGKYD--------LFG------------------ 198 Query: 250 QAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNAEQLMENIGAIQ-VLPKLS 308 + + A A G T Q + W L+ V + E+L EN+ L Sbjct: 199 ---AEPVTAAAAAHGKTPAQAVLRWHLQ--KGFVVFPKSVRRERLEENLDVFDFDLTDTE 253 Query: 309 SSIVHEID 316 + + +D Sbjct: 254 IAAIDAMD 261 >pdb|1HW6|A Chain A, Crystal Structure Of Apo-2,5-Diketo-D-Gluconate Reductase Length = 278 Score = 88.1 bits (216), Expect = 2e-18 Identities = 60/308 (19%), Positives = 94/308 (30%), Gaps = 58/308 (18%) Query: 11 GLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKK 70 G + LG G + + E A + G DTA +Y E V I Sbjct: 11 GNSIPQLGYGVFKVPPADTQRAVEE-----ALEVGYRHIDTAAIYGN--EEGVGAAIAAS 63 Query: 71 KGRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNT-P 129 R L ITTK+ W + G + SL +L L+ VD+ + P P Sbjct: 64 GIARDDLFITTKL-WNDRH---DGDEPA---AAIAESLAKLALDQVDLYLVHWPTPAADN 116 Query: 130 MEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLIPPICEQAEYHMFQREKV 189 M + G+ G S + + + P Q E H +++ Sbjct: 117 YVHAWEKMIELRAAGLTRSIGVSNHLVPHLERIVAA----TGVVPAVNQIELHPAYQQR- 171 Query: 190 EVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKDKILSEEGRRQ 249 ++ + V +W PL GKYD Sbjct: 172 --EITDWAAAHDVKIESWGPLG----QGKYD--------LFG------------------ 199 Query: 250 QAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNAEQLMENIGAIQ-VLPKLS 308 + + A A G T Q + W L+ V + E+L EN+ L Sbjct: 200 ---AEPVTAAAAAHGKTPAQAVLRWHLQ--KGFVVFPKSVRRERLEENLDVFDFDLTDTE 254 Query: 309 SSIVHEID 316 + + +D Sbjct: 255 IAAIDAMD 262 Searching..................................................done Results from round 3 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: pdb|1EXB|A Chain A, Structure Of The Cytoplasmic Beta Subunit-T1... 493 e-140 pdb|1QRQ|A Chain A, Structure Of A Voltage-Dependent K+ Channel ... 490 e-139 pdb|1GVE|A Chain A, Aflatoxin Aldehyde Reductase (Akr7a1) From R... 368 e-103 pdb|1GVE|B Chain B, Aflatoxin Aldehyde Reductase (Akr7a1) From R... 366 e-102 pdb|2ALR| Aldehyde Reductase 313 2e-86 pdb|1AE4| Aldehyde Reductase Complexed With Cofactor And Inhib... 311 1e-85 pdb|1CWN| Crystal Structure Of Porcine Aldehyde Reductase Holo... 311 1e-85 pdb|1HQT|A Chain A, The Crystal Structure Of An Aldehyde Reducta... 310 1e-85 pdb|1EL3|A Chain A, Human Aldose Reductase Complexed With Idd384... 294 2e-80 pdb|2ACQ| Aldose Reductase (E.C.1.1.1.21) Wild Type Complexed ... 293 2e-80 pdb|1ABN| Aldose Reductase (E.C.1.1.1.21) Mutant With Cys 298 ... 293 2e-80 pdb|1HW6|A Chain A, Crystal Structure Of Apo-2,5-Diketo-D-Glucon... 292 6e-80 pdb|1A80| Native 2,5-Diketo-D-Gluconic Acid Reductase A From C... 292 6e-80 pdb|2ACU| Aldose Reductase (E.C.1.1.1.21) Mutant With Tyr 48 R... 290 2e-79 pdb|1AZ1| Alrestatin Bound To C298aW219Y MUTANT HUMAN ALDOSE R... 290 3e-79 pdb|1J96|A Chain A, Human 3alpha-Hsd Type 3 In Ternary Complex W... 289 6e-79 pdb|1IHI|A Chain A, Crystal Structure Of Human Type Iii 3-Alpha-... 289 6e-79 pdb|1AH4| Pig Aldose Reductase, Holo Form >gi|8569627|pdb|1EKO... 277 2e-75 pdb|1DLA|B Chain B, Aldose Reductase (E.C.1.1.1.21) >gi|515112|p... 277 2e-75 pdb|1AH0| Pig Aldose Reductase Complexed With Sorbinil 277 2e-75 pdb|1C9W|A Chain A, Cho Reductase With Nadp+ 273 4e-74 pdb|1AFS|A Chain A, Recombinant Rat Liver 3-Alpha-Hydroxysteroid... 272 6e-74 pdb|1LWI|A Chain A, 3-Alpha-HydroxysteroidDIHYDRODIOL DEHYDROGEN... 271 8e-74 pdb|1RAL| 3-Alpha-Hydroxysteroid Dehydrogenase (E.C.1.1.1.50) 271 9e-74 pdb|1FRB| Fr-1 ProteinNADPHZOPOLRESTAT COMPLEX 269 4e-73 Sequences not found previously or not previously below threshold: CONVERGED! >pdb|1EXB|A Chain A, Structure Of The Cytoplasmic Beta Subunit-T1 Assembly Of Voltage-Dependent K Channels Length = 332 Score = 493 bits (1256), Expect = e-140 Identities = 324/326 (99%), Positives = 324/326 (99%), Gaps = 2/326 (0%) Query: 1 LQFYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKA 60 LQFYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKA Sbjct: 1 LQFYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKA 60 Query: 61 EVVLGNIIKKKG-RRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVV 119 EVVLGNIIKKKG RRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVV Sbjct: 61 EVVLGNIIKKKGWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVV 120 Query: 120 FANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLIPPICEQA 179 FANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLIPPICEQA Sbjct: 121 FANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLIPPICEQA 180 Query: 180 EYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKD 239 EYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKD Sbjct: 181 EYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKD 240 Query: 240 KILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNAEQLMENIG 299 KILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNAEQLMENIG Sbjct: 241 KILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNAEQLMENIG 300 Query: 300 AIQVLPKLSSSIVHEIDSILG-KPYS 324 AIQVLPKLSSSIVHEIDSILG KPYS Sbjct: 301 AIQVLPKLSSSIVHEIDSILGNKPYS 326 >pdb|1QRQ|A Chain A, Structure Of A Voltage-Dependent K+ Channel Beta Subunit pdb|1QRQ|B Chain B, Structure Of A Voltage-Dependent K+ Channel Beta Subunit pdb|1QRQ|C Chain C, Structure Of A Voltage-Dependent K+ Channel Beta Subunit pdb|1QRQ|D Chain D, Structure Of A Voltage-Dependent K+ Channel Beta Subunit Length = 325 Score = 490 bits (1250), Expect = e-139 Identities = 323/325 (99%), Positives = 323/325 (99%), Gaps = 2/325 (0%) Query: 1 LQFYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKA 60 LQFYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKA Sbjct: 1 LQFYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKA 60 Query: 61 EVVLGNIIKKKG-RRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVV 119 EVVLGNIIKKKG RRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVV Sbjct: 61 EVVLGNIIKKKGWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVV 120 Query: 120 FANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLIPPICEQA 179 FANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLIPPICEQA Sbjct: 121 FANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLIPPICEQA 180 Query: 180 EYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKD 239 EYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKD Sbjct: 181 EYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKD 240 Query: 240 KILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNAEQLMENIG 299 KILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNAEQLMENIG Sbjct: 241 KILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNAEQLMENIG 300 Query: 300 AIQVLPKLSSSIVHEIDSILG-KPY 323 AIQVLPKLSSSIVHEIDSILG KPY Sbjct: 301 AIQVLPKLSSSIVHEIDSILGNKPY 325 >pdb|1GVE|A Chain A, Aflatoxin Aldehyde Reductase (Akr7a1) From Rat Liver Length = 327 Score = 368 bits (936), Expect = e-103 Identities = 82/292 (28%), Positives = 135/292 (46%), Gaps = 20/292 (6%) Query: 38 MTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGRRSSLVITTKIFWGGKAETERGLSR 97 + G DTA VYA G++E +LG++ GR V KI + L Sbjct: 28 VRAFLQRGHTEIDTAFVYANGQSETILGDLGLGLGRSGCKV---KIATKAAPMFGKTLKP 84 Query: 98 KHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSM 157 + L+ SL+RLQ VD+ + + PD TP+EET++A + +G + G S + S Sbjct: 85 ADVRFQLETSLKRLQCPRVDLFYLHFPDHGTPIEETLQACHQLHQEGKFVELGLSNYVSW 144 Query: 158 EIMEAYSVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSG 217 E+ E ++ ++ I P Q Y+ R+ VE +L G+ ++PLA G+++G Sbjct: 145 EVAEICTLCKKNGWIMPTVYQGMYNAITRQ-VETELFPCLRHFGLRFYAFNPLAGGLLTG 203 Query: 218 KY----DSGIPPYSRASLKGY-QWLKDKILSEEGRRQQAKLKELQAIAERLGCTLPQL-- 270 +Y G P SR + Q D+ EE A ++ +A+ G T P + Sbjct: 204 RYKYQDKDGKNPESRFFGNPFSQLYMDRYWKEEHFNGIALVE--KALKTTYGPTAPSMIS 261 Query: 271 -AIAWC-----LRNEGVSSVLLGASNAEQLMENIGAIQVLPKLSSSIVHEID 316 A+ W L+ +V+LG S+ EQL +N+ ++ P L ++V D Sbjct: 262 AAVRWMYHHSQLKGTQGDAVILGMSSLEQLEQNLALVEEGP-LEPAVVDAFD 312 >pdb|1GVE|B Chain B, Aflatoxin Aldehyde Reductase (Akr7a1) From Rat Liver Length = 327 Score = 366 bits (931), Expect = e-102 Identities = 82/294 (27%), Positives = 135/294 (45%), Gaps = 20/294 (6%) Query: 36 HLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGRRSSLVITTKIFWGGKAETERGL 95 + G DTA VYA G++E +LG++ GR V KI + L Sbjct: 26 ASVRAFLQRGHTEIDTAFVYANGQSETILGDLGLGLGRSGCKV---KIATKAAPMFGKTL 82 Query: 96 SRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWS 155 + L+ SL+RLQ VD+ + + PD TP+EET++A + +G + G S + Sbjct: 83 KPADVRFQLETSLKRLQCPRVDLFYLHFPDHGTPIEETLQACHQLHQEGKFVELGLSNYV 142 Query: 156 SMEIMEAYSVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIV 215 S E+ E ++ ++ I P Q Y+ R+ VE +L G+ ++PLA G++ Sbjct: 143 SWEVAEICTLCKKNGWIMPTVYQGMYNAITRQ-VETELFPCLRHFGLRFYAFNPLAGGLL 201 Query: 216 SGKY----DSGIPPYSRASLKGY-QWLKDKILSEEGRRQQAKLKELQAIAERLGCTLPQL 270 +G+Y G P SR + Q D+ EE A ++ +A+ G T P + Sbjct: 202 TGRYKYQDKDGKNPESRFFGNPFSQLYMDRDWKEEHFNGIALVE--KALKTTYGPTAPSM 259 Query: 271 ---AIAWC-----LRNEGVSSVLLGASNAEQLMENIGAIQVLPKLSSSIVHEID 316 A+ W L+ +V+LG S+ EQL +N+ ++ P L ++V D Sbjct: 260 ISAAVRWMYHHSQLKGTQGDAVILGMSSLEQLEQNLALVEEGP-LEPAVVDAFD 312 >pdb|2ALR| Aldehyde Reductase Length = 324 Score = 313 bits (795), Expect = 2e-86 Identities = 67/323 (20%), Positives = 123/323 (37%), Gaps = 78/323 (24%) Query: 7 LGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGN 66 L +G ++ +GLGTW + GQ+ + + A G D A +Y E +G Sbjct: 6 LLHTGQKMPLIGLGTWKSEPGQV-----KAAVKYALSVGYRHIDCAAIYG---NEPEIGE 57 Query: 67 IIK------KKGRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVF 120 +K K R L +T+K+ W K E + L+ +L LQLEY+D+ Sbjct: 58 ALKEDVGPGKAVPREELFVTSKL-WNTKHHPE------DVEPALRKTLADLQLEYLDLYL 110 Query: 121 ANR---------PDPN----------TPMEETVRAMTHVINQGMAMYWGTSRWSSMEIME 161 + P P T +ET +A+ ++ +G+ G S ++S +I + Sbjct: 111 MHWPYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDD 170 Query: 162 AYSVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDS 221 SVA + P Q E H + + +L G+ +SPL Sbjct: 171 ILSVAS----VRPAVLQVECHPYLAQN---ELIAHCQARGLEVTAYSPLGSS-------- 215 Query: 222 GIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKE--LQAIAERLGCTLPQLAIAWCLRNE 279 D+ + + L+E + A+AE+ G + Q+ + W ++ + Sbjct: 216 -----------------DRAWRDP--DEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRK 256 Query: 280 GVSSVLLGASNAEQLMENIGAIQ 302 + + ++++NI Sbjct: 257 --VICIPKSITPSRILQNIKVFD 277 >pdb|1AE4| Aldehyde Reductase Complexed With Cofactor And Inhibitor, Alpha Carbon Atoms Only Length = 325 Score = 311 bits (790), Expect = 1e-85 Identities = 66/323 (20%), Positives = 122/323 (37%), Gaps = 78/323 (24%) Query: 7 LGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGN 66 L +G ++ +GLGTW + GQ+ + + A G D A +Y E+ +G Sbjct: 7 LLHTGQKMPLIGLGTWKSEPGQV-----KAAIKYALTVGYRHIDCAAIYG---NELEIGE 58 Query: 67 II------KKKGRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVF 120 + K R L +T+K+ W K E + L+ +L LQLEY+D+ Sbjct: 59 ALTETVGPGKAVPREELFVTSKL-WNTKHHPE------DVEPALRKTLADLQLEYLDLYL 111 Query: 121 ANR---------PDPN----------TPMEETVRAMTHVINQGMAMYWGTSRWSSMEIME 161 + P P T ++T +A+ ++ +G+ G S +SS +I + Sbjct: 112 MHWPYAFERGDNPFPKNADGTIRYDATHYKDTWKALEALVAKGLVRALGLSNFSSRQIDD 171 Query: 162 AYSVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDS 221 SVA + P Q E H + + +L G+ +SPL Sbjct: 172 VLSVAS----VRPAVLQVECHPYLAQN---ELIAHCQARGLEVTAYSPLGSS-------- 216 Query: 222 GIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKE--LQAIAERLGCTLPQLAIAWCLRNE 279 D+ + + L+E +QA+AE+ + Q+ + W ++ + Sbjct: 217 -----------------DRAWRDP--NEPVLLEEPVVQALAEKYNRSPAQILLRWQVQRK 257 Query: 280 GVSSVLLGASNAEQLMENIGAIQ 302 + + ++ +NI Sbjct: 258 --VICIPKSVTPSRIPQNIQVFD 278 >pdb|1CWN| Crystal Structure Of Porcine Aldehyde Reductase Holoenzyme Length = 324 Score = 311 bits (789), Expect = 1e-85 Identities = 66/323 (20%), Positives = 122/323 (37%), Gaps = 78/323 (24%) Query: 7 LGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGN 66 L +G ++ +GLGTW + GQ+ + + A G D A +Y E+ +G Sbjct: 6 LLHTGQKMPLIGLGTWKSEPGQV-----KAAIKYALTVGYRHIDCAAIYG---NELEIGE 57 Query: 67 II------KKKGRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVF 120 + K R L +T+K+ W K E + L+ +L LQLEY+D+ Sbjct: 58 ALTETVGPGKAVPREELFVTSKL-WNTKHHPE------DVEPALRKTLADLQLEYLDLYL 110 Query: 121 ANR---------PDPN----------TPMEETVRAMTHVINQGMAMYWGTSRWSSMEIME 161 + P P T ++T +A+ ++ +G+ G S +SS +I + Sbjct: 111 MHWPYAFERGDNPFPKNADGTIRYDATHYKDTWKALEALVAKGLVRALGLSNFSSRQIDD 170 Query: 162 AYSVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDS 221 SVA + P Q E H + + +L G+ +SPL Sbjct: 171 VLSVAS----VRPAVLQVECHPYLAQN---ELIAHCQARGLEVTAYSPLGSS-------- 215 Query: 222 GIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKE--LQAIAERLGCTLPQLAIAWCLRNE 279 D+ + + L+E +QA+AE+ + Q+ + W ++ + Sbjct: 216 -----------------DRAWRDP--NEPVLLEEPVVQALAEKYNRSPAQILLRWQVQRK 256 Query: 280 GVSSVLLGASNAEQLMENIGAIQ 302 + + ++ +NI Sbjct: 257 --VICIPKSVTPSRIPQNIQVFD 277 >pdb|1HQT|A Chain A, The Crystal Structure Of An Aldehyde Reductase Y50f Mutant- Nadp Complex And Its Implications For Substrate Binding Length = 326 Score = 310 bits (788), Expect = 1e-85 Identities = 65/323 (20%), Positives = 123/323 (37%), Gaps = 78/323 (24%) Query: 7 LGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGN 66 L +G ++ +GLGTW + GQ+ + + A G D A ++ E+ +G Sbjct: 8 LLHTGQKMPLIGLGTWKSEPGQV-----KAAIKYALTVGYRHIDCAAIFG---NELEIGE 59 Query: 67 IIK------KKGRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVF 120 ++ K R L +T+K+ W K E + L+ +L LQLEY+D+ Sbjct: 60 ALQETVGPGKAVPREELFVTSKL-WNTKHHPE------DVEPALRKTLADLQLEYLDLYL 112 Query: 121 ANR---------PDPN----------TPMEETVRAMTHVINQGMAMYWGTSRWSSMEIME 161 + P P T ++T +A+ ++ +G+ G S +SS +I + Sbjct: 113 MHWPYAFERGDNPFPKNADGTIRYDATHYKDTWKALEALVAKGLVRALGLSNFSSRQIDD 172 Query: 162 AYSVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDS 221 SVA + P Q E H + + +L G+ +SPL Sbjct: 173 VLSVAS----VRPAVLQVECHPYLAQN---ELIAHCQARGLEVTAYSPLGSS-------- 217 Query: 222 GIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKE--LQAIAERLGCTLPQLAIAWCLRNE 279 D+ + + L+E +QA+AE+ + Q+ + W ++ + Sbjct: 218 -----------------DRAWRDP--NEPVLLEEPVVQALAEKYNRSPAQILLRWQVQRK 258 Query: 280 GVSSVLLGASNAEQLMENIGAIQ 302 + + ++ +NI Sbjct: 259 --VICIPKSVTPSRIPQNIQVFD 279 >pdb|1EL3|A Chain A, Human Aldose Reductase Complexed With Idd384 Inhibitor pdb|1IEI|A Chain A, Crystal Structure Of Human Aldose Reductase Complexed With The Inhibitor Zenarestat Length = 316 Score = 294 bits (745), Expect = 2e-80 Identities = 65/324 (20%), Positives = 127/324 (39%), Gaps = 75/324 (23%) Query: 5 RNLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVL 64 R L +G ++ LGLGTW + GQ+T + +A D G D A VY + E + Sbjct: 4 RLLLNNGAKMPILGLGTWKSPPGQVT-----EAVKVAIDVGYRHIDCAHVY---QNENEV 55 Query: 65 GNIIKKK-----GRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVV 119 G I++K +R L I +K+ W E+GL + + +L L+L+Y+D+ Sbjct: 56 GVAIQEKLREQVVKREELFIVSKL-WCTYH--EKGL----VKGACQKTLSDLKLDYLDLY 108 Query: 120 FANRPD-------------------PNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIM 160 + P +T + +T AM ++++G+ G S ++ +++ Sbjct: 109 LIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVE 168 Query: 161 EAYSVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYD 220 + + P Q E H + ++ +L + G+ +SPL Sbjct: 169 MILN--KPGLKYKPAVNQIECHPYLTQE---KLIQYCQSKGIVVTAYSPLGS-------- 215 Query: 221 SGIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKE--LQAIAERLGCTLPQLAIAWCLRN 278 D+ ++ + L++ ++AIA + T Q+ I + ++ Sbjct: 216 -----------------PDRPWAKP--EDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQ- 255 Query: 279 EGVSSVLLGASNAEQLMENIGAIQ 302 V+ + E++ EN Sbjct: 256 -RNLVVIPKSVTPERIAENFKVFD 278 >pdb|2ACQ| Aldose Reductase (E.C.1.1.1.21) Wild Type Complexed With Nadp+ And Glucose-6-Phosphate pdb|2ACR| Aldose Reductase (E.C.1.1.1.21) Wild Type Complexed With Nadp+ And Cacodylate pdb|1ADS| Aldose Reductase (E.C.1.1.1.21) Complex With Nadph pdb|1EF3|A Chain A, Fidarestat Bound To Human Aldose Reductase pdb|1EF3|B Chain B, Fidarestat Bound To Human Aldose Reductase pdb|2ACS| Aldose Reductase (E.C.1.1.1.21) Wild Type Complexed With Nadp+ And Citrate pdb|1MAR| Aldose Reductase (E.C.1.1.1.21) Length = 315 Score = 293 bits (744), Expect = 2e-80 Identities = 65/324 (20%), Positives = 127/324 (39%), Gaps = 75/324 (23%) Query: 5 RNLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVL 64 R L +G ++ LGLGTW + GQ+T + +A D G D A VY + E + Sbjct: 3 RLLLNNGAKMPILGLGTWKSPPGQVT-----EAVKVAIDVGYRHIDCAHVY---QNENEV 54 Query: 65 GNIIKKK-----GRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVV 119 G I++K +R L I +K+ W E+GL + + +L L+L+Y+D+ Sbjct: 55 GVAIQEKLREQVVKREELFIVSKL-WCTYH--EKGL----VKGACQKTLSDLKLDYLDLY 107 Query: 120 FANRPD-------------------PNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIM 160 + P +T + +T AM ++++G+ G S ++ +++ Sbjct: 108 LIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVE 167 Query: 161 EAYSVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYD 220 + + P Q E H + ++ +L + G+ +SPL Sbjct: 168 MILN--KPGLKYKPAVNQIECHPYLTQE---KLIQYCQSKGIVVTAYSPLGS-------- 214 Query: 221 SGIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKE--LQAIAERLGCTLPQLAIAWCLRN 278 D+ ++ + L++ ++AIA + T Q+ I + ++ Sbjct: 215 -----------------PDRPWAKP--EDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQ- 254 Query: 279 EGVSSVLLGASNAEQLMENIGAIQ 302 V+ + E++ EN Sbjct: 255 -RNLVVIPKSVTPERIAENFKVFD 277 >pdb|1ABN| Aldose Reductase (E.C.1.1.1.21) Mutant With Cys 298 Replaced By Ser (C298s) Complex With Nadph Length = 315 Score = 293 bits (744), Expect = 2e-80 Identities = 65/324 (20%), Positives = 127/324 (39%), Gaps = 75/324 (23%) Query: 5 RNLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVL 64 R L +G ++ LGLGTW + GQ+T + +A D G D A VY + E + Sbjct: 3 RLLLNNGAKMPILGLGTWKSPPGQVT-----EAVKVAIDVGYRHIDCAHVY---QNENEV 54 Query: 65 GNIIKKK-----GRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVV 119 G I++K +R L I +K+ W E+GL + + +L L+L+Y+D+ Sbjct: 55 GVAIQEKLREQVVKREELFIVSKL-WCTYH--EKGL----VKGACQKTLSDLKLDYLDLY 107 Query: 120 FANRPD-------------------PNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIM 160 + P +T + +T AM ++++G+ G S ++ +++ Sbjct: 108 LIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVE 167 Query: 161 EAYSVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYD 220 + + P Q E H + ++ +L + G+ +SPL Sbjct: 168 MILN--KPGLKYKPAVNQIECHPYLTQE---KLIQYCQSKGIVVTAYSPLGS-------- 214 Query: 221 SGIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKE--LQAIAERLGCTLPQLAIAWCLRN 278 D+ ++ + L++ ++AIA + T Q+ I + ++ Sbjct: 215 -----------------PDRPWAKP--EDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQ- 254 Query: 279 EGVSSVLLGASNAEQLMENIGAIQ 302 V+ + E++ EN Sbjct: 255 -RNLVVIPKSVTPERIAENFKVFD 277 >pdb|1HW6|A Chain A, Crystal Structure Of Apo-2,5-Diketo-D-Gluconate Reductase Length = 278 Score = 292 bits (741), Expect = 6e-80 Identities = 60/311 (19%), Positives = 94/311 (29%), Gaps = 58/311 (18%) Query: 8 GKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNI 67 G + LG G + + E A + G DTA +Y E V I Sbjct: 8 LNDGNSIPQLGYGVFKVPPADTQRAVEE-----ALEVGYRHIDTAAIYGN--EEGVGAAI 60 Query: 68 IKKKGRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPN 127 R L ITTK+ W + G + SL +L L+ VD+ + P P Sbjct: 61 AASGIARDDLFITTKL-WNDRH---DGDEPA---AAIAESLAKLALDQVDLYLVHWPTPA 113 Query: 128 T-PMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLIPPICEQAEYHMFQR 186 M + G+ G S + + + P Q E H + Sbjct: 114 ADNYVHAWEKMIELRAAGLTRSIGVSNHLVPHLERIVAA----TGVVPAVNQIELHPAYQ 169 Query: 187 EKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKDKILSEEG 246 ++ ++ + V +W PL GKYD Sbjct: 170 QR---EITDWAAAHDVKIESWGPLG----QGKYD--------LFG--------------- 199 Query: 247 RRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNAEQLMENIGAIQ-VLP 305 + + A A G T Q + W L+ V + E+L EN+ L Sbjct: 200 ------AEPVTAAAAAHGKTPAQAVLRWHLQ--KGFVVFPKSVRRERLEENLDVFDFDLT 251 Query: 306 KLSSSIVHEID 316 + + +D Sbjct: 252 DTEIAAIDAMD 262 >pdb|1A80| Native 2,5-Diketo-D-Gluconic Acid Reductase A From Corynbacterium Sp. Complexed With Nadph Length = 277 Score = 292 bits (740), Expect = 6e-80 Identities = 60/311 (19%), Positives = 94/311 (29%), Gaps = 58/311 (18%) Query: 8 GKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNI 67 G + LG G + + E A + G DTA +Y E V I Sbjct: 7 LNDGNSIPQLGYGVFKVPPADTQRAVEE-----ALEVGYRHIDTAAIYGN--EEGVGAAI 59 Query: 68 IKKKGRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPN 127 R L ITTK+ W + G + SL +L L+ VD+ + P P Sbjct: 60 AASGIARDDLFITTKL-WNDRH---DGDEPA---AAIAESLAKLALDQVDLYLVHWPTPA 112 Query: 128 T-PMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLIPPICEQAEYHMFQR 186 M + G+ G S + + + P Q E H + Sbjct: 113 ADNYVHAWEKMIELRAAGLTRSIGVSNHLVPHLERIVAA----TGVVPAVNQIELHPAYQ 168 Query: 187 EKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKDKILSEEG 246 ++ ++ + V +W PL GKYD Sbjct: 169 QR---EITDWAAAHDVKIESWGPLG----QGKYD--------LFG--------------- 198 Query: 247 RRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNAEQLMENIGAIQ-VLP 305 + + A A G T Q + W L+ V + E+L EN+ L Sbjct: 199 ------AEPVTAAAAAHGKTPAQAVLRWHLQ--KGFVVFPKSVRRERLEENLDVFDFDLT 250 Query: 306 KLSSSIVHEID 316 + + +D Sbjct: 251 DTEIAAIDAMD 261 >pdb|2ACU| Aldose Reductase (E.C.1.1.1.21) Mutant With Tyr 48 Replaced By His (Y48h) Complexed With Nadp+ And Citrate Length = 315 Score = 290 bits (737), Expect = 2e-79 Identities = 64/324 (19%), Positives = 127/324 (38%), Gaps = 75/324 (23%) Query: 5 RNLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVL 64 R L +G ++ LGLGTW + GQ+T + +A D G D A V+ + E + Sbjct: 3 RLLLNNGAKMPILGLGTWKSPPGQVT-----EAVKVAIDVGYRHIDCAHVH---QNENEV 54 Query: 65 GNIIKKK-----GRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVV 119 G I++K +R L I +K+ W E+GL + + +L L+L+Y+D+ Sbjct: 55 GVAIQEKLREQVVKREELFIVSKL-WCTYH--EKGL----VKGACQKTLSDLKLDYLDLY 107 Query: 120 FANRPD-------------------PNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIM 160 + P +T + +T AM ++++G+ G S ++ +++ Sbjct: 108 LIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVE 167 Query: 161 EAYSVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYD 220 + + P Q E H + ++ +L + G+ +SPL Sbjct: 168 MILN--KPGLKYKPAVNQIECHPYLTQE---KLIQYCQSKGIVVTAYSPLGS-------- 214 Query: 221 SGIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKE--LQAIAERLGCTLPQLAIAWCLRN 278 D+ ++ + L++ ++AIA + T Q+ I + ++ Sbjct: 215 -----------------PDRPWAKP--EDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQ- 254 Query: 279 EGVSSVLLGASNAEQLMENIGAIQ 302 V+ + E++ EN Sbjct: 255 -RNLVVIPKSVTPERIAENFKVFD 277 >pdb|1AZ1| Alrestatin Bound To C298aW219Y MUTANT HUMAN ALDOSE Reductase pdb|1AZ2| Citrate Bound, C298aW219Y MUTANT HUMAN ALDOSE REDUCTASE Length = 315 Score = 290 bits (735), Expect = 3e-79 Identities = 65/324 (20%), Positives = 127/324 (39%), Gaps = 75/324 (23%) Query: 5 RNLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVL 64 R L +G ++ LGLGTW + GQ+T + +A D G D A VY + E + Sbjct: 3 RLLLNNGAKMPILGLGTWKSPPGQVT-----EAVKVAIDVGYRHIDCAHVY---QNENEV 54 Query: 65 GNIIKKK-----GRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVV 119 G I++K +R L I +K+ W E+GL + + +L L+L+Y+D+ Sbjct: 55 GVAIQEKLREQVVKREELFIVSKL-WCTYH--EKGL----VKGACQKTLSDLKLDYLDLY 107 Query: 120 FANRPD-------------------PNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIM 160 + P +T + +T AM ++++G+ G S ++ +++ Sbjct: 108 LIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVE 167 Query: 161 EAYSVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYD 220 + + P Q E H + ++ +L + G+ +SPL Sbjct: 168 MILN--KPGLKYKPAVNQIECHPYLTQE---KLIQYCQSKGIVVTAYSPLGS-------- 214 Query: 221 SGIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKE--LQAIAERLGCTLPQLAIAWCLRN 278 D+ ++ + L++ ++AIA + T Q+ I + ++ Sbjct: 215 -----------------PDRPYAKP--EDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQ- 254 Query: 279 EGVSSVLLGASNAEQLMENIGAIQ 302 V+ + E++ EN Sbjct: 255 -RNLVVIPKSVTPERIAENFKVFD 277 >pdb|1J96|A Chain A, Human 3alpha-Hsd Type 3 In Ternary Complex With Nadp And Testosterone pdb|1J96|B Chain B, Human 3alpha-Hsd Type 3 In Ternary Complex With Nadp And Testosterone Length = 323 Score = 289 bits (732), Expect = 6e-79 Identities = 61/333 (18%), Positives = 118/333 (35%), Gaps = 72/333 (21%) Query: 8 GKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNI 67 G + LG GT+ ++ A + LA + G + D+A VY E +G Sbjct: 10 LNDGHFMPVLGFGTYA--PAEVPKSKALEAVKLAIEAGFHHIDSAHVY---NNEEQVGLA 64 Query: 68 IK-----KKGRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFAN 122 I+ +R + T+K+ W E + L+ SL+ LQL+YVD+ + Sbjct: 65 IRSKIADGSVKREDIFYTSKL-WSNSHRPEL------VRPALERSLKNLQLDYVDLYLIH 117 Query: 123 RPDPNTPMEE-------------------TVRAMTHVINQGMAMYWGTSRWSSMEIMEAY 163 P P EE T AM + G+A G S ++ + Sbjct: 118 FPVSVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMIL 177 Query: 164 SVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGI 223 + + P+C Q E H + ++ +L + + + +S L Sbjct: 178 N--KPGLKYKPVCNQVECHPYFNQR---KLLDFCKSKDIVLVAYSALGS----------- 221 Query: 224 PPYSRASLKGYQWLKDKILSEEGRRQQAKLKE--LQAIAERLGCTLPQLAIAWCLRNEGV 281 +++ + L++ L A+A++ T +A+ + L+ Sbjct: 222 -------------HREEPWVDP--NSPVLLEDPVLCALAKKHKRTPALIALRYQLQ--RG 264 Query: 282 SSVLLGASNAEQLMENIGAIQ-VLPKLSSSIVH 313 VL + N +++ +N+ + L + Sbjct: 265 VVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAID 297 >pdb|1IHI|A Chain A, Crystal Structure Of Human Type Iii 3-Alpha-Hydroxysteroid DehydrogenaseBILE ACID BINDING PROTEIN (AKR1C2) COMPLEXED With Nadp+ And Ursodeoxycholate pdb|1IHI|B Chain B, Crystal Structure Of Human Type Iii 3-Alpha-Hydroxysteroid DehydrogenaseBILE ACID BINDING PROTEIN (AKR1C2) COMPLEXED With Nadp+ And Ursodeoxycholate Length = 323 Score = 289 bits (732), Expect = 6e-79 Identities = 61/333 (18%), Positives = 118/333 (35%), Gaps = 72/333 (21%) Query: 8 GKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNI 67 G + LG GT+ ++ A + LA + G + D+A VY E +G Sbjct: 10 LNDGHFMPVLGFGTYA--PAEVPKSKALEAVKLAIEAGFHHIDSAHVY---NNEEQVGLA 64 Query: 68 IK-----KKGRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFAN 122 I+ +R + T+K+ W E + L+ SL+ LQL+YVD+ + Sbjct: 65 IRSKIADGSVKREDIFYTSKL-WSNSHRPEL------VRPALERSLKNLQLDYVDLYLIH 117 Query: 123 RPDPNTPMEE-------------------TVRAMTHVINQGMAMYWGTSRWSSMEIMEAY 163 P P EE T AM + G+A G S ++ + Sbjct: 118 FPVSVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMIL 177 Query: 164 SVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGI 223 + + P+C Q E H + ++ +L + + + +S L Sbjct: 178 N--KPGLKYKPVCNQVECHPYFNQR---KLLDFCKSKDIVLVAYSALGS----------- 221 Query: 224 PPYSRASLKGYQWLKDKILSEEGRRQQAKLKE--LQAIAERLGCTLPQLAIAWCLRNEGV 281 +++ + L++ L A+A++ T +A+ + L+ Sbjct: 222 -------------HREEPWVDP--NSPVLLEDPVLCALAKKHKRTPALIALRYQLQ--RG 264 Query: 282 SSVLLGASNAEQLMENIGAIQ-VLPKLSSSIVH 313 VL + N +++ +N+ + L + Sbjct: 265 VVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAID 297 >pdb|1AH4| Pig Aldose Reductase, Holo Form pdb|1EKO|A Chain A, Pig Aldose Reductase Complexed With Idd384 Inhibitor pdb|1AH3| Aldose Reductase Complexed With Tolrestat Inhibitor Length = 315 Score = 277 bits (703), Expect = 2e-75 Identities = 62/321 (19%), Positives = 123/321 (38%), Gaps = 71/321 (22%) Query: 6 NLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLG 65 + +G ++ LGLGTW + G++T + +A D G D A VY + EV LG Sbjct: 4 LVLYTGAKMPILGLGTWKSPPGKVT-----EAVKVAIDLGYRHIDCAHVYQN-ENEVGLG 57 Query: 66 ---NIIKKKGRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFAN 122 + + +R L I +K+ W E+ L + + +L L+L+Y+D+ + Sbjct: 58 LQEKLQGQVVKREDLFIVSKL-WCTDH--EKNL----VKGACQTTLRDLKLDYLDLYLIH 110 Query: 123 RPDP-------------------NTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAY 163 P + ET AM ++++G+ G S ++ +++ + Sbjct: 111 WPTGFKPGKDPFPLDGDGNVVPDESDFVETWEAMEELVDEGLVKAIGVSNFNHLQVEKIL 170 Query: 164 SVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGI 223 + + P Q E H + ++ +L E G+ +SPL Sbjct: 171 N--KPGLKYKPAVNQIEVHPYLTQE---KLIEYCKSKGIVVTAYSPLGS----------- 214 Query: 224 PPYSRASLKGYQWLKDKILSEEGRRQQAKLKE--LQAIAERLGCTLPQLAIAWCLRNEGV 281 D+ ++ + L++ ++AIA + T Q+ I + ++ Sbjct: 215 --------------PDRPWAKP--EDPSLLEDPRIKAIAAKYNKTTAQVLIRFPMQ--RN 256 Query: 282 SSVLLGASNAEQLMENIGAIQ 302 V+ + E++ EN Sbjct: 257 LIVIPKSVTPERIAENFQVFD 277 >pdb|1DLA|B Chain B, Aldose Reductase (E.C.1.1.1.21) pdb|1DLA|C Chain C, Aldose Reductase (E.C.1.1.1.21) pdb|1DLA|A Chain A, Aldose Reductase (E.C.1.1.1.21) pdb|1DLA|D Chain D, Aldose Reductase (E.C.1.1.1.21) Length = 314 Score = 277 bits (703), Expect = 2e-75 Identities = 62/321 (19%), Positives = 123/321 (38%), Gaps = 71/321 (22%) Query: 6 NLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLG 65 + +G ++ LGLGTW + G++T + +A D G D A VY + EV LG Sbjct: 3 LVLYTGAKMPILGLGTWKSPPGKVT-----EAVKVAIDLGYRHIDCAHVYQN-ENEVGLG 56 Query: 66 ---NIIKKKGRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFAN 122 + + +R L I +K+ W E+ L + + +L L+L+Y+D+ + Sbjct: 57 LQEKLQGQVVKREDLFIVSKL-WCTDH--EKNL----VKGACQTTLRDLKLDYLDLYLIH 109 Query: 123 RPDP-------------------NTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAY 163 P + ET AM ++++G+ G S ++ +++ + Sbjct: 110 WPTGFKPGKDPFPLDGDGNVVPDESDFVETWEAMEELVDEGLVKAIGVSNFNHLQVEKIL 169 Query: 164 SVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGI 223 + + P Q E H + ++ +L E G+ +SPL Sbjct: 170 N--KPGLKYKPAVNQIEVHPYLTQE---KLIEYCKSKGIVVTAYSPLGS----------- 213 Query: 224 PPYSRASLKGYQWLKDKILSEEGRRQQAKLKE--LQAIAERLGCTLPQLAIAWCLRNEGV 281 D+ ++ + L++ ++AIA + T Q+ I + ++ Sbjct: 214 --------------PDRPWAKP--EDPSLLEDPRIKAIAAKYNKTTAQVLIRFPMQ--RN 255 Query: 282 SSVLLGASNAEQLMENIGAIQ 302 V+ + E++ EN Sbjct: 256 LIVIPKSVTPERIAENFQVFD 276 >pdb|1AH0| Pig Aldose Reductase Complexed With Sorbinil Length = 316 Score = 277 bits (703), Expect = 2e-75 Identities = 62/321 (19%), Positives = 123/321 (38%), Gaps = 71/321 (22%) Query: 6 NLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLG 65 + +G ++ LGLGTW + G++T + +A D G D A VY + EV LG Sbjct: 5 LVLYTGAKMPILGLGTWKSPPGKVT-----EAVKVAIDLGYRHIDCAHVYQN-ENEVGLG 58 Query: 66 ---NIIKKKGRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFAN 122 + + +R L I +K+ W E+ L + + +L L+L+Y+D+ + Sbjct: 59 LQEKLQGQVVKREDLFIVSKL-WCTDH--EKNL----VKGACQTTLRDLKLDYLDLYLIH 111 Query: 123 RPDP-------------------NTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAY 163 P + ET AM ++++G+ G S ++ +++ + Sbjct: 112 WPTGFKPGKDPFPLDGDGNVVPDESDFVETWEAMEELVDEGLVKAIGVSNFNHLQVEKIL 171 Query: 164 SVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGI 223 + + P Q E H + ++ +L E G+ +SPL Sbjct: 172 N--KPGLKYKPAVNQIEVHPYLTQE---KLIEYCKSKGIVVTAYSPLGS----------- 215 Query: 224 PPYSRASLKGYQWLKDKILSEEGRRQQAKLKE--LQAIAERLGCTLPQLAIAWCLRNEGV 281 D+ ++ + L++ ++AIA + T Q+ I + ++ Sbjct: 216 --------------PDRPWAKP--EDPSLLEDPRIKAIAAKYNKTTAQVLIRFPMQ--RN 257 Query: 282 SSVLLGASNAEQLMENIGAIQ 302 V+ + E++ EN Sbjct: 258 LIVIPKSVTPERIAENFQVFD 278 >pdb|1C9W|A Chain A, Cho Reductase With Nadp+ Length = 315 Score = 273 bits (691), Expect = 4e-74 Identities = 61/332 (18%), Positives = 120/332 (35%), Gaps = 76/332 (22%) Query: 8 GKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNI 67 + ++ +GLGTW + GQ+ + + +A D G D A Y E +G Sbjct: 6 LSTKAKMPIVGLGTWQSPPGQV-----KEAVKVAIDAGYRHIDCAYAY---YNEHEVGEA 57 Query: 68 IK-----KKGRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFAN 122 I+ K RR L I +K+ W ER L + E + +L L+L+Y+D+ + Sbjct: 58 IQEKIKEKAVRREDLFIVSKL-WPTC--FERKL----LKEAFQKTLTDLKLDYLDLYLIH 110 Query: 123 RPDPNTPMEE-------------------TVRAMTHVINQGMAMYWGTSRWSSMEIMEAY 163 P P +E M ++++G+ G S ++ +I Sbjct: 111 WPQGLQPGKELFPKDDQGNVLTSKITFLDAWEVMEELVDEGLVKALGVSNFNHFQIERIL 170 Query: 164 SVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGI 223 + + P+ Q E H + ++ +L E H G+ +SPL Sbjct: 171 N--KPGLKHKPVTNQVECHPYLTQE---KLIEYCHSKGITVTAYSPLGS----------- 214 Query: 224 PPYSRASLKGYQWLKDKILSEEGRRQQAKLKE--LQAIAERLGCTLPQLAIAWCLRNEGV 281 ++ ++ + L++ ++ IA + T Q+ I + ++ Sbjct: 215 --------------PNRPWAKP--EDPSLLEDPKIKEIAAKHKKTSAQVLIRFHIQ--RN 256 Query: 282 SSVLLGASNAEQLMENIGAIQ-VLPKLSSSIV 312 V+ + ++ EN L + + Sbjct: 257 VVVIPKSVTPARIHENFQVFDFQLSDQEMATI 288 >pdb|1AFS|A Chain A, Recombinant Rat Liver 3-Alpha-Hydroxysteroid Dehydrogenase (3-Alpha-Hsd) Complexed With Nadp And Testosterone pdb|1AFS|B Chain B, Recombinant Rat Liver 3-Alpha-Hydroxysteroid Dehydrogenase (3-Alpha-Hsd) Complexed With Nadp And Testosterone Length = 323 Score = 272 bits (689), Expect = 6e-74 Identities = 58/324 (17%), Positives = 117/324 (35%), Gaps = 71/324 (21%) Query: 5 RNLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVL 64 R G + LG GT T ++ + +A DNG FD+A +Y + E + Sbjct: 7 RVALNDGNFIPVLGFGT--TVPEKVAKDEVIKATKIAIDNGFRHFDSAYLY---EVEEEV 61 Query: 65 GNIIK-----KKGRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVV 119 G I+ +R + T+K+ W E + L+ +L+ QL+YVD+ Sbjct: 62 GQAIRSKIEDGTVKREDIFYTSKL-WSTFHRPEL------VRTCLEKTLKSTQLDYVDLY 114 Query: 120 FANRP-------------------DPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIM 160 + P + +T AM + G+A G S ++ ++ Sbjct: 115 IIHFPMALQPGDIFFPRDEHGKLLFETVDICDTWEAMEKCKDAGLAKSIGVSNFNCRQLE 174 Query: 161 EAYSVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYD 220 + + P+C Q E H++ + ++ + + +++ L Sbjct: 175 RILN--KPGLKYKPVCNQVECHLYLNQ---SKMLDYCKSKDIILVSYCTLGSS------- 222 Query: 221 SGIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKE--LQAIAERLGCTLPQLAIAWCLRN 278 +DK ++ + L + L AIA++ T +A+ + L+ Sbjct: 223 -----------------RDKTWVDQ--KSPVLLDDPVLCAIAKKYKQTPALVALRYQLQ- 262 Query: 279 EGVSSVLLGASNAEQLMENIGAIQ 302 L+ + NA+++ E + Sbjct: 263 -RGVVPLIRSFNAKRIKELTQVFE 285 >pdb|1LWI|A Chain A, 3-Alpha-HydroxysteroidDIHYDRODIOL DEHYDROGENASE FROM Rattus Norvegicus pdb|1LWI|B Chain B, 3-Alpha-HydroxysteroidDIHYDRODIOL DEHYDROGENASE FROM Rattus Norvegicus Length = 322 Score = 271 bits (688), Expect = 8e-74 Identities = 58/324 (17%), Positives = 117/324 (35%), Gaps = 71/324 (21%) Query: 5 RNLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVL 64 R G + LG GT T ++ + +A DNG FD+A +Y + E + Sbjct: 7 RVALNDGNFIPVLGFGT--TVPEKVAKDEVIKATKIAIDNGFRHFDSAYLY---EVEEEV 61 Query: 65 GNIIK-----KKGRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVV 119 G I+ +R + T+K+ W E + L+ +L+ QL+YVD+ Sbjct: 62 GQAIRSKIEDGTVKREDIFYTSKL-WSTFHRPEL------VRTCLEKTLKSTQLDYVDLY 114 Query: 120 FANRP-------------------DPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIM 160 + P + +T AM + G+A G S ++ ++ Sbjct: 115 IIHFPMALQPGDIFFPRDEHGKLLFETVDICDTWEAMEKCKDAGLAKSIGVSNFNCRQLE 174 Query: 161 EAYSVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYD 220 + + P+C Q E H++ + ++ + + +++ L Sbjct: 175 RILN--KPGLKYKPVCNQVECHLYLNQ---SKMLDYCKSKDIILVSYCTLGSS------- 222 Query: 221 SGIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKE--LQAIAERLGCTLPQLAIAWCLRN 278 +DK ++ + L + L AIA++ T +A+ + L+ Sbjct: 223 -----------------RDKTWVDQ--KSPVLLDDPVLCAIAKKYKQTPALVALRYQLQ- 262 Query: 279 EGVSSVLLGASNAEQLMENIGAIQ 302 L+ + NA+++ E + Sbjct: 263 -RGVVPLIRSFNAKRIKELTQVFE 285 >pdb|1RAL| 3-Alpha-Hydroxysteroid Dehydrogenase (E.C.1.1.1.50) Length = 308 Score = 271 bits (688), Expect = 9e-74 Identities = 58/324 (17%), Positives = 117/324 (35%), Gaps = 71/324 (21%) Query: 5 RNLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVL 64 R G + LG GT T ++ + +A DNG FD+A +Y + E + Sbjct: 7 RVALNDGNFIPVLGFGT--TVPEKVAKDEVIKATKIAIDNGFRHFDSAYLY---EVEEEV 61 Query: 65 GNIIK-----KKGRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVV 119 G I+ +R + T+K+ W E + L+ +L+ QL+YVD+ Sbjct: 62 GQAIRSKIEDGTVKREDIFYTSKL-WSTFHRPEL------VRTCLEKTLKSTQLDYVDLY 114 Query: 120 FANRP-------------------DPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIM 160 + P + +T AM + G+A G S ++ ++ Sbjct: 115 IIHFPMALQPGDIFFPRDEHGKLLFETVDICDTWEAMEKCKDAGLAKSIGVSNFNCRQLE 174 Query: 161 EAYSVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYD 220 + + P+C Q E H++ + ++ + + +++ L Sbjct: 175 RILN--KPGLKYKPVCNQVECHLYLNQ---SKMLDYCKSKDIILVSYCTLGSS------- 222 Query: 221 SGIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKE--LQAIAERLGCTLPQLAIAWCLRN 278 +DK ++ + L + L AIA++ T +A+ + L+ Sbjct: 223 -----------------RDKTWVDQ--KSPVLLDDPVLCAIAKKYKQTPALVALRYQLQ- 262 Query: 279 EGVSSVLLGASNAEQLMENIGAIQ 302 L+ + NA+++ E + Sbjct: 263 -RGVVPLIRSFNAKRIKELTQVFE 285 >pdb|1FRB| Fr-1 ProteinNADPHZOPOLRESTAT COMPLEX Length = 315 Score = 269 bits (682), Expect = 4e-73 Identities = 64/330 (19%), Positives = 117/330 (35%), Gaps = 72/330 (21%) Query: 8 GKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNI 67 + ++ +GLGTW + Q+ + + A D G D A Y E +G Sbjct: 6 LSTKAKMPIVGLGTWKSPPNQV-----KEAVKAAIDAGYRHIDCAYAYC---NENEVGEA 57 Query: 68 IK-----KKGRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFAN 122 I+ K +R L I +K+ W E+ L + E + +L L+L+Y+D+ + Sbjct: 58 IQEKIKEKAVQREDLFIVSKL-WPTC--FEKKL----LKEAFQKTLTDLKLDYLDLYLIH 110 Query: 123 RP-------------------DPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAY 163 P T E M +++QG+ G S ++ +I Sbjct: 111 WPQGLQPGKELFPKDDQGRILTSKTTFLEAWEGMEELVDQGLVKALGVSNFNHFQIERLL 170 Query: 164 SVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGI 223 + + P+ Q E H + ++ +L + H G+ +SPL Sbjct: 171 N--KPGLKHKPVTNQVECHPYLTQE---KLIQYCHSKGISVTAYSPLGS----------- 214 Query: 224 PPYSRASLKGYQWLKDKILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSS 283 R S K + + K+KE IA + T Q+ I + ++ Sbjct: 215 --PDRPSAKP---------EDPSLLEDPKIKE---IAAKHEKTSAQVLIRFHIQ--RNVV 258 Query: 284 VLLGASNAEQLMENIGAIQ-VLPKLSSSIV 312 V+ + ++ ENI L + + Sbjct: 259 VIPKSVTPSRIQENIQVFDFQLSDEEMATI 288 Database: data/pdbaa Posted date: Jul 25, 2003 4:28 PM Number of letters in database: 2,731,406 Number of sequences in database: 12,515 Lambda K H 0.313 0.158 0.462 Lambda K H 0.270 0.0553 0.230 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 4522840 Number of Sequences: 12515 Number of extensions: 159135 Number of successful extensions: 817 Number of sequences better than 1.0e-01: 72 Number of HSP's better than 0.1 without gapping: 52 Number of HSP's successfully gapped in prelim test: 20 Number of HSP's that attempted gapping in prelim test: 460 Number of HSP's gapped (non-prelim): 76 length of query: 324 length of database: 2,731,406 effective HSP length: 45 effective length of query: 279 effective length of database: 2,168,231 effective search space: 604936449 effective search space used: 604936449 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.8 bits) X3: 64 (24.9 bits) S1: 41 (21.2 bits) S2: 73 (32.6 bits)