Introduction

Myosins are a large family of motor proteins found in eukaryotic cells.The term myosin was originally used to describe a group of similar, but nonidentical, ATPases found in striated and smooth muscle cells.Later on numerous intracelular motility functions of these motor proteins were discovered.Myosnis are classified in to different subclasses based on the phylogenetic analysis of N-terminal ATPase domain.Myosinome database provides information on sequence, structure and function of myosin classes II, V and VI from five different organisms.





Myosin Type Organism PDB-Structures KEGG pathways Review Articles
Myosin type II Homo sapiens Mus musculus

Drosophila melanogaster

Caenorhabditis elegans

Saccharomyces cerevisiae
1b7t 1br1 1br2 1br4 1d0x 1d0y 1d0z 1d1a 1d1b 1d1c 1dfk 1dfl 1fmv 1fmw 1g8x 1i84 1jwy 1jx2 1kk7 1kk8 1kqm 1kwo 1l2o 1lkx 1lvk 1m8q 1mma 1mmd 1mmg 1mmn 1mnd 1mne 1mvw 1o18 1o19 1o1a 1o1b 1o1c 1o1d 1o1e 1o1f 1o1g 1qvi 1s5g 1sr6 1vom 1w9i 1w9j 1w9k 1w9l 1yv3 2aka 2ec6 2ekv 2ekw 2jhr 2jj9 2mys 2os8 2otg 2ovk 2oy6 3bz7 3bz8 3bz9 3dtp 3i5f 3i5g 3i5h 3i5i map04270 map05410 map04260 map04810 map04530 map04666 map04670 map05416 Of mice and men: Relevance of cellular and molecular characterizations of myosin IIA to MYH9-related human disease.Cell Adh Migr. 2007 1(3):152-5
Myosin type V Homo sapiens Mus musculus

Drosophila melanogaster

Caenorhabditis elegans

Saccharomyces cerevisiae
1oe9 1w7i 1w7j 1w8j 2bkh 2bki 2dfs - Myosin V from head to tail . Cellular and Molecular Life Sciences 65(9):1378-1389
Myosin type VI Homo sapiens Mus musculus

Drosophila melanogaster

Caenorhabditis elegans

Saccharomyces cerevisiae
2v26 2vas 2vb6 - Myosin VI: an innovative motor that challenged the swinging lever arm hypothesis.Nature Reviews Molecular Cell Biology 11, 128-137