Align your sequence with the genome of a given superfamily using CLUSTALW [Help] Superfamily name Select superfamily 14-3-3 protein 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase IspF 2Fe-2S ferredoxin-like 3-carboxy-cis,cis-mucoante lactonizing enzyme 4Fe-4S ferredoxins 4-helical cytokines 4'-phosphopantetheinyl transferase 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain 5' to 3' exonuclease, C-terminal subdomain 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK 6-phosphogluconate dehydrogenase C-terminal domain-like Acidic mitochondrial matrix protein p32 Acid phosphatase/Vanadium-dependent haloperoxidase Acid proteases ACMNPV telokin-like protein Aconitase Aconitase B, N-terminal domain Aconitase iron-sulfur domain ACP-like Actin-crosslinking proteins Actin depolymerizing proteins Actin-like ATPase domain Actinoxanthin-like Acyl-CoA binding protein Acyl-CoA dehydrogenase C-terminal domain-like Acyl-CoA dehydrogenase NM domain-like Acyl-CoA N-acyltransferases (Nat) Acylphosphatase-like Ada DNA repair protein, N-terminal domain (N-Ada 10) ADC-like ADC synthase Adenine nucleotide alpha hydrolases-like Adenylyl and guanylyl cyclase catalytic domain A DNA-binding domain in eukaryotic transcription factors ADP-ribosylation ADP ribosyl cyclase-like Agglutinin Agouti-related protein A heparin-binding domain AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC Alanine racemase-like, C-terminal domain Aldehyde ferredoxin oxidoreductase, C-terminal domains Aldehyde ferredoxin oxidoreductase, N-terminal domain ALDH-like Aldolase Alkaline phosphatase-like Allophycocyanin linker chain (domain) alpha-2-Macroglobulin receptor associated protein (RAP) domain 1 alpha-Amylase inhibitor tendamistat alpha-Amylases, C-terminal beta-sheet domain alpha/beta-Hydrolases alpha/beta knot alpha-catenin/vinculin alpha-D-mannose-specific plant lectins alpha-helical ferredoxin alpha-ketoacid dehydrogenase kinase, N-terminal domain alpha-L-arabinanase Alpha-L RNA-binding motif Alpha-lytic protease prodomain Alpha-macroglobulin receptor domain Alpha subunit of glutamate synthase, C-terminal domain Amb V allergen Amidase signature (AS) enzymes Aminoacid dehydrogenase-like, N-terminal domain Aminoimidazole ribonucleotide synthetase (PurM) C-terminal domain Aminoimidazole ribonucleotide synthetase (PurM) N-terminal domain An anticodon-binding domain of class I aminoacyl-tRNA synthetases Anaphylotoxins (complement system) An insect antifreeze protein Ankyrin repeat Annexin Anthrax protective antigen Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases Anticodon-binding domain of Class II aaRS Anticodon-binding domain of PheRS Antifungal protein (AGAFP) Antigen MPT63/MPB63 (immunoprotective extracellular protein) Antioxidant defence protein AhpD Anti-sigma factor antagonist SpoIIaa Anti-sigma factor AsiA Antitermination factor NusB Apical membrane antigen 1 Apolipophorin-III Apolipoprotein Apolipoprotein A-II domain AraD-like aldolase/epimerase Archaeosine tRNA-guanine transglycosylase, C-terminal additional domains Arginase/deacetylase Argininosuccinate synthetase, C-terminal domain Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain ARID-like ARM repeat Aromatic aminoacid monoxygenases, catalytic and oligomerization domains Aromatic compound dioxygenase Arp2/3 complex 16 kDa subunit ARPC5 Arp2/3 complex 21 kDa subunit ARPC3 Arp2/3 complex subunits Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domain Aspartate/glutamate racemase Aspartate/ornithine carbamoyltransferase Aspartate receptor, ligand-binding domain ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase ATP syntase (F1-ATPase), gamma subunit Avidin/streptavidin A virus capsid protein alpha-helical domain B12-dependend dehydatases associated subunit B3/B4 domain of PheRS, PheT Bacterial adhesins Bacterial enterotoxins Bacterial exopeptidase dimerisation domain Bacterial GAP domain Bacterial immunoglobulin/albumin-binding domains Bacterial luciferase-like Bacterial muramidases Bacterial protein-export protein SecB Bactericidal permeability-increasing protein, BPI Bacteriochlorophyll A protein Bacteriocin AS-48 BAG domain BAH domain Barrier-to-autointegration factor, BAF Barstar (barnase inhibitor) Barwin-like endoglucanases Baseplate structural protein gp11 B-box zinc-binding domain Bcl-2 inhibitors of programmed cell death Bcr-Abl oncoprotein oligomerization domain BEACH domain beta-carbonic anhydrase, cab beta-catenin-interacting protein ICAT Beta-D-glucan exohydrolase, C-terminal domain beta-Galactosidase, domain 5 beta-Galactosidase/glucuronidase domain Betaine-homocysteine S-methyltransferase beta-Lactamase/D-ala carboxypeptidase beta-lactamase-inhibitor protein, BLIP beta-N-acetylhexosaminidase-like domain beta-sandwich domain of Sec23/24 Bet v1-like Bifunctional dehydrogenase/ferrochelatase Met8p, dimerisation and C-terminal domains Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin Blood coagulation inhibitor (disintegrin) BolA-like Bowman-Birk inhibitor, BBI BPTI-like BRCA2 helical domain BRCA2 tower domain BRCT domain B repeat unit of collagen binding surface protein (cna) Bromelain inhibitor VI (cysteine protease inhibitor) Bromodomain BTV inner layer core protein vp3 C2 domain (Calcium/lipid-binding domain, CaLB) C2H2 and C2HC zinc fingers Cadherin CAD & PB1 domains Calcium ATPase, ATP-binding domain N Calcium ATPase, transduction domain A Calpain large subunit, middle domain (domain III) Calponin-homology domain, CH-domain cAMP-binding domain-like Cap-Gly domain Carbamate kinase-like Carbamoyl phosphate synthetase, large subunit connection domain Carbamoyl phosphate synthetase, small subunit N-terminal domain Carbohydrate-binding domain Carbohydrate binding domain Carbonic anhydrase Carboxypeptidase D, a regulatory domain Carboxypeptidase inhibitor Casein kinase II beta subunit Caspase-like Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b CBD9-like CBS-domain Cdc48 domain 2-like Cell cycle regulatory proteins Cell-division inhibitor MinC, C-terminal domain Cell-division inhibitor MinC, N-terminal domain Cell division protein MinE topological specificity domain Cell-division protein ZipA, C-terminal domain Cell growth inhibitor/plasmid maintainance toxic component Cellulases Cellulose-binding domain Cellulose docking domain, dockering Chalcone isomerase Chaperone J-domain Chelatase Chemotaxis phosphatase CheZ Chemotaxis receptor methyltransferase CheR, N-terminal domain CheW-like CheY-binding domain of CheA CheY-like Chitinase insertion domain Cholecystokinin A receptor, N-domain Choline binding domain of autolysin C-LytA Chondroitin AC/alginate lyase Chorismate lyase Chorismate mutase II Chromo domain-like CI-2 family of serine protease inhibitors Citrate synthase Class I glutamine amidotransferase-like Class II aaRS and biotin synthetases Clathrin adaptor appendage domain Clathrin adaptor appendage domain Clathrin coat assembly domain Clathrin heavy-chain terminal domain Clavaminate synthase-like Cloroperoxidase ClpP/crotonase ClpS-like CoA-dependent acyltransferases CoA transferase Cobalamin (vitamin B12)-binding domain Cobalamin (vitamin B12)-dependent enzymes Cobalt precorrin-4 methyltransferase CbiF CO dehydrogenase flavoprotein C-terminal domain-like CO dehydrogenase ISP C-domain like CO dehydrogenase molybdoprotein N-domain-like Colicin Colicin E3 immunity protein Colicin E3 translocation domain Colicin E immunity proteins Colipase-like Complement control module/SCR domain Composite domain of metallo-dependent hydrolases Concanavalin A-like lectins/glucanases Conserved core of transcriptional regulatory protein vp16 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 Copper amine oxidase, domain 3 (catalytic) Copper amine oxidase, domain N Copper amine oxidase, domains 1 and 2 Core binding factor beta, CBF Crambin-like Creatinase/aminopeptidase Creatinase/prolidase N-terminal domain Crustacean CHH/MIH/GIH neurohormone Cryptochrome/photolyase FAD-binding domain Cryptochrome/photolyase, N-terminal domain C-terminal activation domain (CTAD) of HIF-1alpha C-terminal autoproteolytic domain of nucleoporin nup98 C-terminal domain of adenylylcyclase associated protein C-terminal domain of alpha and beta subunits of F1 ATP synthase C-terminal domain of arginine repressor C-terminal domain of B transposition protein C-terminal domain of DFF45/ICAD (DFF-C domain) C-terminal domain of octopus hemocyanin C-terminal domain of phosphatidylinositol transfer protein sec14p C-terminal domain of ProRS C-terminal domain of RNA polymerase alpha subunit C-terminal domain of TolA C-terminal domain of transcriptional repressors C-terminal effector domain of the bipartite response regulators C-terminal, gelsolin-like domain of Sec23/24 C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase C-terminal UvrC-binding domain of UvrB C-type lectin-like Culin homology domain Culin repeat Cupredoxins Cutinase-like Cu,Zn superoxide dismutase-like Cyanase C-terminal domain Cyanovirin-N Cyclin-like Cyclophilin (peptidylprolyl isomerase) Cyclotides Cystatin/monellin Cysteine hydrolase Cysteine proteinases Cysteine-rich DNA binding domain, (DM domain) Cysteine-rich domain Cysteine-rich domain of the chaperone protein DnaJ. Cysteine rich protein B (HcpB) Cystine-knot cytokines Cytidine deaminase-like Cytochrome b5 Cytochrome c Cytochrome c oxidase subunit E Cytochrome c oxidase subunit h Cytochrome f, large domain Cytochrome P450 Cytochromes Cytokine Cytosolic phospholipase A2 catalytic D-aminoacid aminotransferase-like PLP-dependent enzymes D-aminopeptidase, middle and C-terminal domains DBL homology domain (DH-domain) DEATH domain Defensin-like DegV-like Dehydroquinate synthase-like delta-Endotoxin (insectocide), middle domain delta-Endotoxin (insectocide), N-terminal domain Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) DFP DNA/pantothenate metabolism flavoprotein DHH phosphoesterases DHS-like NAD/FAD-binding domain Diaminopimelate epimerase Di-copper centre-containing domain Dihydrofolate reductases Dihydropteroate synthetase-like Diisopropylfluorophosphatase (phosphotriesterase, DFP) Dimeric alpha+beta barrel Dimeric C-terminal domain of membrane protein TonB Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit Diol dehydratase, gamma subunit Dipeptide transport protein Dipeptidyl peptidase I (cathepsin C), exclusion domain Dipeptidyl peptidase IV/CD26, N-terminal domain Diphtheria toxin, C-terminal domain Diphtheria toxin, middle domain Disulfide bond isomerase, DsbC, N-terminal domain Disulphide-bond formation facilitator (DSBA), insertion domain DNA-binding C-terminal domain of the transcription factor MotA DNA-binding domain DNA-binding domain of intron endonuclease I-TevI DNA-binding domain of Mlu1-box binding protein MBP1 DNA-binding domain of retroviral integrase DNA-binding protein Sso10b (AlbA) DNA breaking-rejoining enzymes DNA clamp DNA damage-inducible protein DinI DNA-glycosylase DNA glycosylase DNA helicase RuvA subunit, C-terminal domain DNA ligase/mRNA capping enzyme, catalytic domain DNA polymerase beta-like, second domain DNA polymerase beta, N-terminal domain-like DNA polymerase III clamp loader subunits, C-terminal domain DNA primase DNA primase DnaG catalytic core DNA repair protein MutM (Fpg) DNA repair protein MutS, domain I DNA repair protein MutS, domain II DNA repair protein MutS, domain III DNA repair protein Rad51, N-terminal domain DNase I-like DNA topoisomerase I domain DNA topoisomerase IV, alpha subunit Domain of early E2A DNA-binding protein, ADDBP Domain of poly(ADP-ribose) polymerase Domain of the SRP/SRP receptor G-proteins Double Clp-N motif D-ribose-5-phosphate isomerase (RpiA), lid domain DsrC, the gamma subunit of dissimilatory sulfite reductase dsRNA-binding domain-like D-Tyr tRNAtyr deacylase Duplicated hybrid motif Dynein light chain 8 (DLC8) E2 regulatory, transactivation domain Ecotin, trypsin inhibitor Ectatomin, A & B chains eEF-1beta-like Effector domain of the protein kinase pkn/prk1 EF-G/eEF-2 domains III and V EF-hand EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain EGF/Laminin eIF1-like Elafin-like Electron transport accessory proteins Elongation factor TFIIS domain 2 Elongation factor Ts (EF-Ts), dimerisation domain Endoplasmic reticulum protein ERP29, C-domain Enolase C-terminal domain-like Enolase N-terminal domain-like ENTH/VHS domain Enzyme IIa from lactose specific PTS, IIa-lac Enzyme IIB-cellobiose Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain Epsilon subunit of F1F0-ATP synthase C-terminal domain Epsilon subunit of F1F0-ATP synthase N-terminal domain Epsilon subunit of mitochondrial F1F0-ATP synthase EPT/RTPC-like Equinatoxin II (eqtII, tenebrosin C) E set domains Esterase/acetylhydrolase ETFP adenine nucleotide-binding domain-like Eukaryotic DNA topoisomerase I, dispensable insert domain Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment Eukaryotic RPB5 N-terminal domain Eukaryotic type KH-domain (eKH-domain) EV matrix protein Exotoxin A, middle domain F41 fragment of flagellin FabD/lysophospholipase-like FAD-binding domain FAD-linked oxidases, C-terminal domain FAD-linked oxidoreductase FAD-linked reductases, C-terminal domain FAD/NAD-linked reductases, dimerisation (C-terminal) domain FAH Family 10 polysaccharide lyase FAS1 domain FAT domain of focal adhesion kinase Fatty acid responsive transcription factor FadR, C-terminal domain F-box domain Fe,Mn superoxide dismutase (SOD), C-terminal domain Fe,Mn superoxide dismutase (SOD), N-terminal domain Fe-only hydrogenase Fe-only hydrogenase smaller subunit Ferredoxin reductase-like, C-terminal NADP-linked domain Ferredoxin thioredoxin reductase (FTR), catalytic beta chain Ferritin-like Fertilization protein FF domain Fibre shaft of virus attachment proteins Fibrinogen C-terminal domain-like Fibronectin type III Fibronectin type I module Firefly luciferase-like FIS-like FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) FKBP-like Flagellar transcriptional activator FlhD Flavoproteins FliG FMN-binding split barrel FMN-linked oxidoreductases FMT C-terminal domain-like F-MuLV receptor-binding domain Formate dehydrogenase/DMSO reductase, domains 1-3 Formate/glycerate dehydrogenase catalytic domain-like Formiminotransferase domain of formiminotransferase-cyclodeaminase. Formylmethanofuran:tetrahydromethanopterin formyltransferase Formyltransferase Frataxin-like Frizzled cystein-rich domain Fructose permease, subunit IIb Fucose-binding lectin II (PA-IIL) Fumarylacetoacetate hydrolase, FAH, N-terminal domain Functional domain of the splicing factor Prp18 Fungal elicitin FYVE/PHD zinc finger GAF domain-like Galactose-binding domain-like Galactose mutarotase-like Galactose oxidase, central domain gamma-Crystallin-like Ganglioside M2 (gm2) activator GEF domain of SopE toxin gene 59 helicase assembly protein GFP-like GHMP Kinase GIY-YIG endonuclease GLA-domain GlnB-like Globin-like Glucocorticoid receptor-like (DNA-binding domain) Glucose permease domain IIB Glutaminase/Asparaginase Glutamine synthase/guanido kinase Glutamine synthetase, N-terminal domain Glutamyl tRNA-reductase catalytic, N-terminal domain Glutamyl tRNA-reductase dimerization domain Glutathione S-transferase (GST), C-terminal domain Glutathione synthetase ATP-binding domain-like Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain Glycerol-3-phosphate (1)-acyltransferase Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase GMP synthetase C-terminal dimerisation domain Golgi alpha-mannosidase II gp120 core gp9 Granulin repeat GreA transcript cleavage protein, N-terminal domain GroEL apical domain-like GroEL equatorial domain-like chaperone equatorial domain GroEL-intermediate domain like GroES-like Growth factor receptor domain GTPase activation domain, GAP GTP cyclohydrolase I feedback regulatory protein, GFRP Guanido kinase N-terminal domain Gurmarin-like GW domain GYF domain HAD-like Hairpin loop containing domain-like Head and neck region of the ectodomain of NDV fusion glycoprotein Head-binding domain of phage P22 tailspike protein Head decoration protein D (gpD, major capsid protein D) Head domain of nucleotide exchange factor GrpE Head-to-tail joining protein W, gpW Heat shock protein 70kD (HSP70), C-terminal substrate-binding fragment Heat-stable enterotoxin B Hedgehog/DD-pepidase Hedgehog/intein (Hint) domain "Helical backbone" metal receptor Helical domain of Sec23/24 Helical scaffold and wing domains of SecA Helix-loop-helix DNA-binding domain Heme-binding protein A (HasA) Heme chaperone CcmE Heme-dependent peroxidases Heme-linked catalases Heme oxygenase Hemerythrin Hemocyanin, N-terminal domain Hemolysin expression modulating protein HHA Hemopexin-like domain Heparin-binding domain from vascular endothelial growth factor Hepatitis B viral capsid (hbcag) Herpes virus serine proteinase, assemblin HIPIP (high potential iron protein) His-Me finger endonucleases Histidine-containing phosphotransfer domain, HPT domain Histidine decarboxylase Histone-fold Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain HIT-like HIV-1 VPU cytoplasmic domain HMG-box H-NS histone-like proteins Homeodomain-like Homing endonucleases Homodimeric domain of signal transducing histidine kinase HPr kinase/phoshatase HprK N-terminal domain HPr-like HRDC-like HSC20 (HSCB), C-terminal oligomerisation domain HSP20-like chaperones Hsp33 domain HSP40/DnaJ peptide-binding domain Hyaluronate lyase-like, central domain Hyaluronate lyase-like, C-terminal domain HybD-like Hypothetical protein HI1434 (YbaK homologue) Hypothetical protein MT938 (MTH938) Hypothetical protein MTH1020 Hypothetical protein MTH1184 Hypothetical protein MTH1615 Hypothetical protein MTH1880 Hypothetical protein MTH538 Hypothetical protein MTH777 (MT0777) Hypothetical protein MTH865 Hypothetical protein YjbJ IHF-like DNA-binding proteins IIA domain of mannose transporter, IIA-Man Immunoglobulin-binding domains Influenza virus matrix protein M1 Inhibitor of apoptosis (IAP) repeat Initiation factor IF2/eIF5b, domain 3 Inorganic pyrophosphatase Inosine monophosphate dehydrogenase (IMPDH) Insect cysteine-rich antifreeze protein Insect pheromon/odorant-binding proteins Insert subdomain of RNA polymerase alpha subunit Insulin-like Integral outer membrane protein TolC, efflux pump component Integrin alpha N-terminal domain Integrin beta tail domain Integrin domains Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain Interleukin 8-like chemokines Invasin/intimin cell-adhesion fragments IP3 receptor type 1 binding core, domain 1 Iron-dependent represor protein, dimerization domain Isocitrate/Isopropylmalate dehydrogenases ISP domain Killer toxin KP6 alpha-subunit Kix domain of CBP (creb binding protein) Kringle-like Ku heterodimer subunits L30e-like L9 N-domain-like Lactate & malate dehydrogenases, C-terminal domain Lactobacillus maltose phosphorylase, N-terminal domain lambda integrase-like, N-terminal domain lambda repressor-like DNA-binding domains Lamin A/C globular tail domain L-aminopeptidase D-Ala-esterase/amidase L-aspartase-like LCCL domain LDL receptor-like module L domain-like Leech antihemostatic proteins LEM domain Leucine aminopeptidase (Aminopeptidase A), N-terminal domain Leukocidin (pore-forming toxin) Leukotriene A4 hydrolase N-terminal domain LexA/Signal peptidase L-fucose isomerase, C-terminal domain L-fucose isomerase, N-terminal and second domains LigA subunit of an aromatic-ring-opening dioxygenase LigAB LigB subunit of an aromatic-ring-opening dioxygenase LigAB Light-harvesting complex subunits Lipase/lipooxygenase domain (PLAT/LH2 domain) Lipocalins Lipoxigenase Low density lipoprotein (LDL) receptor YWTD domain Lrp/AsnC-like transcriptional regulator C-terminal domain Lumazine synthase LuxS/MPP-like metallohydrolase LysM domain Lysozyme-like Maf/Ham1 Major capsid protein gp5 Major surface antigen p30, SAG1 Malate synthase G Mannose 6-phosphate receptor domain Mannose-binding lectins MDM2 Mechanosensitive channel protein MscS (YggB), C-terminal domain Membrane penetration protein mu1 Metal-binding domain Metallo-dependent hydrolases Metallo-dependent phosphatases Metallo-hydrolase/oxidoreductase Metalloprotease inhibitor Metalloproteases ("zincins"), catalytic domain Metallothionein Methane monooxygenase hydrolase, gamma subunit Methanol dehydrogenase subunit Methenyltetrahydromethanopterin cyclohydrolase Methionine synthase activation domain-like Methionine synthase domain Methionyl-tRNA synthetase (MetRS), Zn-domain Methuselah ectodomain Methylamine dehydrogenase, L chain Methylated DNA-protein cysteine methyltransferase, C-terminal domain Methylated DNA-protein cysteine methyltransferase domain Methyl-coenzyme M reductase alpha and beta chain C-terminal domain Methyl-coenzyme M reductase subunits Methylesterase CheB, C-terminal domain Methylglyoxal synthase-like Met repressor-like MHC antigen-recognition domain MHC class II-associated invariant chain ectoplasmic trimerization domain Microbial and mitochondrial ADK, insert "zinc finger" domain Microbial ribonucleases Midkine Mitochondrial import receptor subunit Tom20 Mitotic arrest deficient-like 1, Mad1 MoaD/ThiS Moesin tail domain Molybdemum cofactor-binding domain Molybdenum cofactor biosynthesis protein C, MoaC Molybdenum cofactor biosynthesis protein MoeA, C-terminal domain Molybdenum cofactor biosynthesis protein MoeA, N-terminal and linker domains Molybdenum cofactor biosynthesis protein MoeB Molybdenum cofactor biosynthesis proteins Molybdopterin synthase subunit MoaE Monomethylamine methyltransferase MtmB Monooxygenase (hydroxylase) regulatory protein MOP-like Mosquitocidal delta-endotoxin CytB mRNA triphosphatase CET1 Mss4-like MTH1175-like MTH1598-like Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains MurCD N-terminal domain MurD-like peptide ligases, catalytic domain MurD-like peptide ligases, peptide-binding domain MurE/MurF N-terminal domain mu transposase, C-terminal domain Myosin phosphatase inhibitor 17kDa protein, CPI-17 Myosin S1 fragment, N-terminal domain N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) mutase PurE N-acetylmuramoyl-L-alanine amidase-like NAD-binding domain of HMG-CoA reductase NADH oxidase/flavin reductase NAD(P)-binding Rossmann-fold domains NAD(P)-linked oxidoreductase Neurophysin II Neurotoxin B-IV Neurotoxin III (ATX III) Nickel-iron hydrogenase, large subunit Nickel-iron hydrogenase, small subunit Nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT) Nicotinic receptor ligand binding domain-like Nitric oxide (NO) synthase oxygenase domain Nitrilase/N-carbamoyl-D-aminoacid amidohydrolase Nitrile hydratase alpha chain Nitrous oxide reductase, N-terminal domain Non-globular alpha+beta subunits of globular proteins NSP3 homodimer N-terminal domain of alpha and beta subunits of F1 ATP synthase N-terminal domain of bifunctional PutA protein N-terminal domain of cbl (N-cbl) N-terminal domain of DnaB helicase N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1 N-terminal domain of MutM-like DNA repair proteins N-terminal domain of phosphatidylinositol transfer protein sec14p N-terminal domain of the delta subunit of the F1F0-ATP synthase N-terminal domains of the minor coat protein g3p N-terminal nucleophile aminohydrolases (Ntn hydrolases) N-terminal Zn binding domain of HIV integrase NTF2-like Nuclear receptor coactivator interlocking domain Nuclear receptor coactivator Src-1 Nuclear receptor ligand-binding domain Nuclease A inhibitor (NuiA) Nucleic acid-binding proteins Nucleoplasmin core Nucleoside 2-deoxyribosyltransferase Nucleoside diphosphate kinases Nucleoside hydrolase Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain Nucleotide-binding domain Nucleotide-diphospho-sugar transferases Nucleotidyltransferase Nucleotidyltransferase substrate binding subunit/domain Nucleotidylyl transferase Nudix N-utilization substance G protein NusG, insert domain N-utilization substance G protein NusG, N-terminal domain Obg GTP-binding protein N-terminal domain Ohr/OsmC resistance proteins Olfactory marker protein omega toxin-like OMPA-like OMPT-like Oncogene products Orange carotenoid protein, N-terminal domain Origin of replication-binding domain, RBD-like Ornithine decarboxylase C-terminal domain Ornithine decarboxylase N-terminal "wing" domain Osmotin, thaumatin-like protein Outer arm dynein light chain 1 Outer capsid protein sigma 3 Outer membrane phospholipase A (OMPLA) Outer surface protein A Outer surface protein C (OspC) Ovomucoid/PCI-1 like inhibitors p53-like transcription factors p53 tetramerization domain p8-MTCP1 PABC (PABP) domain Paculovirus p35 PAH2 domain PapD-like P-domain of calnexin/calreticulin PDZ domain-like PEBP-like Pectin lyase-like Penicillin-binding protein 2x (pbp-2x), c-terminal domain Penicillin-binding protein 5, C-terminal domain Penicillin binding protein dimerisation domain Pentein PEP carboxykinase-like PEP carboxykinase N-terminal domain Pepsin inhibitor-3 Peptide deformylase Peptide methionine sulfoxide reductase Peptidyl-tRNA hydrolase Perfringolysin Peridinin-chlorophyll protein Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex Periplasmic binding protein-like I Periplasmic binding protein-like II Periplasmic chaperone C-domain PFL-like glycyl radical enzymes PGBD-like Phage fibre proteins Phage tail proteins PH domain-like Pheromone-binding domain of LuxR-like quorum-sensing transcription factors Pheromone ER-23 PHL pollen allergen PHM/PNGase F Phoshotransferase/anion transport protein Phosphatidylinositol-specific phospholipase C (PI-PLC) Phosphoenolpyruvate/pyruvate domain Phosphofructokinase Phosphoglucomutase, C-terminal domain Phosphoglucomutase, first 3 domains Phosphoglycerate kinase Phosphoglycerate mutase-like Phosphohistidine domain Phosphoinositide-binding clathrin adaptor, N-terminal domain Phospholipase A2, PLA2 Phospholipase C/P1 nuclease Phospholipase D/nuclease Phosphosugar isomerase Phosphotyrosine protein phosphatases I (Phosphotyrosine protein) phosphatases II Photosynthetic reaction centre, H-chain, cytoplasmic domain Photosystem I subunit PsaD Pilin PI-Pfui intein middle domain PK beta-barrel domain-like PKD domain Plakin repeat Plant inhibitors of proteinases and amylases Plant lectins/antimicrobial peptides Plasmid maintenance system epsilon/zeta, antidote epsilon subunit P-loop containing nucleotide triphosphate hydrolases PLP-binding barrel PLP-dependent transferases PMP inhibitors Pollen allergen Phl P 6 Polo domain Poly(A) polymerase, C-terminal domain Poly(A) polymerase, middle domain Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 2 and 5 Polypeptide chain release factor 2 (RF2) Porin chaperone SurA, peptide-binding domain Porins Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain POZ domain PR-1-like PreATP-grasp domain Precorrin-8x methylmutase Prefoldin Pre-protein croslinking domain of SecA Prion-like Prismane protein-like (Pro)aerolysin, pore-forming lobe Probable ACP-binding domain of malonyl-CoA ACP transacylase Probable bacterial effector-binding domain Probable GTPase Der, C-terminal domain Profilin (actin-binding protein) Prokaryotic AspRS, insert domain Prokaryotic ribosomal protein L17 Prokaryotic type I DNA topoisomerase Prokaryotic type KH domain (pKH-domain) Prolyl oligopeptidase, N-terminal domain Protease propeptides/inhibitors Proteasome activator reg(alpha) Proteinase A inhibitor IA3 Protein HNS-dependent expression A; HdeA Protein kinase-like (PK-like) Protein-L-isoaspartyl O-methyltransferase, C-terminal domain Protein prenylyltransferase Protein serine/threonine phosphatase 2 Protein serine/threonine phosphatase 2C, catalytic domain Protein serine/threonine phosphatase 2C, C-terminal domain Protozoan pheromone proteins PRTase-like Pseudouridine synthase Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH) PTS-regulatory domain, PRD Purine and uridine phosphorylases Purple acid phosphatase, N-terminal domain PurS subunit of FGAM synthetase Putative cell cycle protein MesJ, middle and C-terminal domain Putative DNA-binding domain Putative glycerate kinase (hypothetical protein TM1585) Putative methyltransferase TM0872, insert domain Putative transcriptional regulator TM1602, C-terminal domain PX domain Pyk2-associated protein beta ARF-GAP domain PYP-like sensor domain (PAS domain) Pyridoxine 5'-phosphate synthase Pyrimidine nucleoside phosphorylase C-terminal domain Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) Pyruvate-ferredoxin oxidoreductase, PFOR, domain III Pyruvate kinase, C-terminal domain Quinohemoprotein amine dehydrogenase A chain, domain 3 Quinohemoprotein amine dehydrogenase C chain Quinolinic acid phosphoribosyltransferase, C-terminal domain Quinolinic acid phosphoribosyltransferase, N-terminal domain Quinoprotein alcohol dehydrogenase-like R1 subunit of ribonucleotide reductase, N-terminal domain R3H domain Rab geranylgeranyltransferase alpha-subunit, insert domain Rad50 coiled-coil Zn hook Ran-binding protein mog1p Ran-GTPase activating protein 1 (RanGAP1), C-terminal domain Rap30/74 interaction domains Ras GEF RBP11-like subunits of RNA polymerase RBP12 subunit of RNA polymerase II RCC1/BLIP-II RecA protein, C-terminal domain RecG, N-terminal domain Recombination endonuclease VII, C-terminal and dimerization domains Regulator of G-protein signalling, RGS Regulatory domain in the aminoacid metabolism Regulatory factor Nef Regulatory protein AraC Replication modulator SeqA, C-terminal DNA-binding domain Replication terminator protein (Tus) Repressor of bacterial conjugation FinO Resolvase-like Retroviral matrix proteins Retrovirus capsid protein C-terminal domain Retrovirus capsid protein, N-terminal core domain Retrovirus zinc finger-like domains Rhodanese/Cell cycle control phosphatase Rho termination factor, N-terminal domain Riboflavin kinase Riboflavin synthase domain-like Ribokinase-like Ribonuclease domain of colicin E3 Ribonuclease H-like Ribonuclease Rh-like Ribosomal protein L10e Ribosomal protein L11, C-terminal domain Ribosomal protein L11, N-terminal domain Ribosomal protein L13 Ribosomal protein L14 Ribosomal protein L1 Ribosomal protein L19 (L19e) Ribosomal protein L20 Ribosomal protein L22 Ribosomal protein L25-like Ribosomal protein L29 (L29p) Ribosomal protein L30p/L7e Ribosomal protein L31e Ribosomal protein L32e Ribosomal protein L36 Ribosomal protein L39e Ribosomal protein L4 Ribosomal protein L5 Ribosomal protein L6 Ribosomal protein L7/12, oligomerisation (N-terminal) domain Ribosomal protein L9 C-domain Ribosomal protein S10 Ribosomal protein S16 Ribosomal protein S18 Ribosomal protein S19 Ribosomal protein S20 Ribosomal protein S2 Ribosomal protein S3 C-terminal domain Ribosomal protein S5 domain 2-like Ribosomal protein S6 Ribosomal protein S7 Ribosomal protein S8 Ribosomal proteins L15p and L18e Ribosomal proteins L23 and L15e Ribosome binding protein Y (YfiA homologue) Ribosome inactivating proteins (RIP) Ribosome recycling factor, RRF Ribulose-phoshate binding barrel Ricin B-like lectins RING finger domain, C3HC4 RmlC-like cupins RNA 3'-terminal phosphate cyclase, RPTC, insert domain RNA bacteriophage capsid protein RNA-binding domain, RBD RNA polymerase omega subunit RNA polymerase sigma subunit RNA polymerase subunit RPB10 RNase A-like RNase III endonuclease catalytic domain RNI-like ROP protein Rotavirus NSP2 fragment, C-terminal domain Rotavirus NSP2 fragment, N-terminal domain RPB5-like RNA polymerase subunit RuBisCo, C-terminal domain RuBisCO, large subunit, small (N-terminal) domain RuBisCo LSMT C-terminal, substrate-binding domain RuBisCO, small subunit Rubredoxin-like Rudiment single hybrid motif RuvA domain 2-like S13-like H2TH domain S15/NS1 RNA-binding domain SacY-like RNA-binding domain S-adenosyl-L-methionine-dependent methyltransferases S-adenosylmethionine decarboxylase S-adenosylmethionine synthetase SAICAR synthase-like SAM/Pointed domain SAND domain-like SAP domain Saposin Satiety factor CART (cocaine and amphetamine regulated transcript) Scaffolding protein gpD of bacteriophage procapsid Scavenger receptor cysteine-rich (SRCR) domain Scorpion toxin-like Sea anemone toxin k SEA domain Sec1/munc18-like (SM) proteins Sec7 domain Second domain of FERM Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor Serine proteinase inhibitor lekti, domain one Serine proterase inhibitors Serpins Serralysin-like metalloprotease, C-terminal domain Serum albumin-like SET domain Seven-hairpin glycosyltransferases SH2 domain SH3-domain Sialidases (neuraminidases) Signal peptide-binding domain Signal recognition particle alu RNA binding heterodimer, SRP9/14 Single hybrid motif SinR repressor dimerisation domain-like SirA-like SIS domain Six-hairpin glycosyltransferases Skp1 dimerisation domain-like Skp1-Skp2 dimerisation domains Smac/diablo SMAD/FHA domain SMAD MH1 domain Small protein B (SmpB) Smc hinge domain Sm-like ribonucleoproteins Snake toxin-like SNARE-like Soluble quinoprotein glucose dehydrogenase Soluble secreted chemokine inhibitor, VCCI Sortase Spectrin repeat Spermadhesin, CUB domain Sporulation responce regulatory protein Spo0B SRF-like SRP19 ssDNA-binding transcriptional regulator domain Staphylococcal nuclease Staphylokinase/streptokinase Starch-binding domain STAT Sterol carrier protein, SCP STI-like Substrate-binding domain of HMG-CoA reductase Subtilisin inhibitor Subtilisin-like Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain Succinyl-CoA synthetase domains SufE (YhnA) Sugar phosphatases Sulfite oxidase, middle catalytic domain Sulfite reductase, domains 1 and 3 Sulfite reductase hemoprotein (SiRHP), domains 2 and 4 Superantigen toxins, C-terminal domain Superoxide reductase-like SurE-like Swiveling domain of the glycerol dehydratase reactivase alpha subunit T4 endonuclease V Tachycitin Tachylectin-2 TAF(II)230 TBP-binding fragment Tail-associated lysozyme gp5, N-terminal domain TATA-box binding protein-like Tautomerase/MIF TAZ domain TB module/8-cys domain Telomeric repeat binding factor (TRF) dimerisation domain Terpenoid cylases/Protein prenyltransferases Terpenoid synthases Testis/brain RNA-binding protein (TB-RBP) Tetracyclin repressor-like, C-terminal domain Tetrahydrobiopterin biosynthesis enzymes-like Tetraspanin TGS-like Thermostable phytase (3-phytase) Thermostable subdomain from chicken villin headpiece The spindle assembly checkpoint protein mad2 Theta subunit of DNA polymerase III Thiamin diphosphate-binding fold (THDP-binding) Thiamin phosphate synthase Thiamin pyrophosphokinase, catalytic domain Thiamin pyrophosphokinase, substrate-binding domain Thioesterase/thiol ester dehydrase-isomerase Thiolase-like Thiol:disulfide interchange protein DsbD, N-terminal domain Thiol oxidase Erv2p Thioredoxin-like Threonyl-tRNA synthetase (ThrRS), second 'additional' domain Thymidylate synthase-complementing protein Thy1 Thymidylate synthase/dCMP hydroxymethylase Thyroglobulin type-1 domain TIMP-like TK C-terminal domain-like TMV-like viral coat proteins TNF-like TNF receptor-like TolA/TonB C-terminal domain TolB, C-terminal domain TolB, N-terminal domain Toll/Interleukin receptor TIR domain Tp47 lipoprotein, middle and C-terminal domains Tp47 lipoprotein, N-terminal domain TPR-like TRADD, N-terminal domain TRAF domain-like Transcriptional factor tubby, C-terminal domain Transcription factor IIA (TFIIA), N-terminal domain Transcription factor IIA (TFIIA), N-terminal domain Transcription factor NusA, N-terminal domain Transcription factor STAT-4 N-domain Transcription-state regulator AbrB, the N-terminal DNA recognition domain Transducin (alpha subunit), insertion domain Transducin (heterotrimeric G protein), gamma chain Transferrin receptor ectodomain, apical domain Transferrin receptor ectodomain, C-terminal domain Transglutaminase, two C-terminal domains (Trans)glycosidases Translational machinery components Translational regulator protein regA Translation initiation factor eIF4e Translation initiation factor IF3, C-terminal domain Translation initiation factor IF3, N-terminal domain Translation proteins Translation proteins SH3-like domain Transthyretin (prealbumin) Trefoil Tricorn protease N-terminal domain Tricorn protease N-terminal domain Trimeric LpxA-like enzymes Triosephosphate isomerase (TIM) tRNA-binding arm tRNA CCA-adding enzyme, C-terminal domains tRNA-guanine transglycosylase tRNA splicing endonuclease, C-terminal domain tRNA splicing endonuclease EdnA, N-terminal domain tRNA splicing product Appr>p cyclic nucleotide phosphodiesterase TrpR-like Trp RNA-binding attenuation protein (TRAP) Trypsin-like serine proteases Tryptophan synthase beta subunit-like PLP-dependent enzymes t-snare proteins TSP-1 type 1 repeat Tubulin chaperone cofactor A Tubulin, C-terminal domain Tubulin, GTPase domain Tudor/PWWP Tumor suppressor gene product Apc Type 1 cytotoxic necrotizing factor, catalytic domain Type I dockerin domain Type II 3-dehydroquinate dehydratase Type II DNA topoisomerase Type III antifreeze protein Type III secretory system chaperone Type X cellulose binding domain, CBDX UBA-like UBC-like Ubiquitin-like Ubiquitin-protein ligase E3a, Hect catalytic domain (E6ap) UDP-glucose dehydrogenase (UDPGDH), C-terminal (UDP-binding) domain UDP-Glycosyltransferase/glycogen phosphorylase Undecaprenyl diphosphate synthase Upper collar protein gp10 (connector protein) Uracil-DNA glycosylase inhibitor protein Urease, beta-subunit Urease, gamma-subunit Urease metallochaperone UreE, C-terminal domain Urease metallochaperone UreE, N-terminal domain Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain Uroporphyrinogen decarboxylase, UROD Uroporphyrinogen III synthase (U3S, HemD) Uteroglobin-like ValRS/IleRS/LeuRS editing domain Variable surface antigen VlsE VHL Viral chemokine binding protein m3 Viral coat and capsid proteins Viral DNA-binding domain Viral glycoprotein, central and dimerisation domains Viral protein domain Viral proteins Virus attachment protein Vitelline membrane outer protein-I (VMO-I) V-region of surface antigen I/II (SA I/II, PAC) VSV matrix protein vWA-like WD40-repeat "Winged helix" DNA-binding domain Wiscott-Aldrich syndrome protein, WASP, C-terminal domain WW domain X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal domain XRCC4, N-terminal domain Xylose isomerase-like YbaB-like YchN-like YebC-like Yest killer toxins YggU-like YhbC-like, C-terminal domain YhbC-like, N-terminal domain YhbY-like YjeF N-terminal domain-like YjgF-like YlxR-like YopH tyrosine phosphatase N-terminal domain Ypt/Rab-GAP domain of gyp1p YrdC/RibB YVTN repeat-like/Quinoprotein amine dehydrogenase Zinc beta-ribbon Zinc-binding domain of translation initiation factor 2 beta Zinc domain conserved in yeast copper-regulated transcription factors Zn2/Cys6 DNA-binding domain Zn-binding domains of ADDBP Zn-binding ribosomal proteins Zn-dependent exopeptidases Zn-finger domain of Sec23/24 Genome name [For eg, Yersinia pestis. Click here for genome list] Paste your set of amino acid sequences in PIR format:
