DSDBASE is a database on disulphide bonds in proteins that provides information on native disulphides and those which are stereochemically possible between pairs of residues in a protein.
One of the potential uses of such a disulphide database is to design site-directed mutants in order to enhance the thermal stability of the protein in question. Another important application is to employ this database for proposing 3D models of disulphide-rich polypeptides like toxins and small proteins by searching for sub-structural motifs which are compatible with the derived disulphide bond connectivity. The user can obtain information about disulphide bonds of a particular protein of interest or probe the database for multiple disulphide bonded systems of particular connectivity. [...]
Several new features are added to the database. Click here for more
Three different datasets are created for modelling purpose:
1. PDB entries (April 2003 release)
2. Non-redundant dataset (25% sequence identity cutoff)
3. Native disulphide bonds from the non-redundant dataset
Click here for previous release statistics
Distribution of Disulphide Bonds in DSDBASE
S.No
Dataset
No. of Proteins
Native Disulphides
Modelled Disulphides
Total Disulphides
1
Non-redundant(April-2003)
2,849
2,170
147,722
149,892
2
Full database (April-2003)
19,612
31,657
2,353,960
2,385,617
Contact : R.Sowdhamini(mini@ncbs.res.in)) Group : Vinayagam A Pugalenthi G (pugal@ncbs.res.in) Ratna Rajesh T (rajesh.thangudu@univ-reunion.fr)
Last modified : Mon June 9 09:01:02 IST 2003