DSDBASE is a database on disulphide bonds in proteins that provides information on native disulphides and those which are stereochemically possible between pairs of residues in a protein.This Database is available as two different datasets:
1. PDB entries (April 2003 release)
2. Non-redundant dataset (25% sequence identity cutoff list)
Click here for previous release statistics
Distribution of Disulphide Bonds in DSDBASE
S.No
Dataset
No. of Proteins
Native Disulphides
Modelled Disulphides
Total Disulphides
1
Non-redundant(April-2003)
2,849
2,170
147,722
149,892
2
Full database (April-2003)
19,612
31,657
2,353,960
2,385,617
Search is now available on PDB-April 2003 release also.
An option is provided on the search result page to filter the hits on the basis of user-defined sequence identity cut-off.
One of the potential uses of such a disulphide database is to design site-directed mutants in order to enhance the thermal stability of the protein in question. Another important application is to employ this database for proposing 3D models of disulphide-rich polypeptides like toxins and small proteins by searching for sub-structural motifs which are compatible with the derived disulphide bond connectivity. The user can obtain information about disulphide bonds of a particular protein of interest or probe the database for multiple disulphide bonded systems of particular connectivity. [...]
Contact : R.Sowdhamini(mini@ncbs.res.in))
Group : Vinayagam A Ratna Rajesh T (ratna@ncbs.res.in) Pugalenthi G (pugal@ncbs.res.in)
Last modified : Mon June 9 09:01:02 IST 2003