DSDBASE is a database on disulphide bonds in proteins that provides information on native disulphides and those which are stereochemically possible between pairs of residues in a protein.

This Database is available as two different datasets:

1. PDB entries (April 2003 release)

2. Non-redundant dataset (25% sequence identity cutoff list)

Click here for previous release statistics

Distribution of Disulphide Bonds in DSDBASE

S.No

Dataset

No. of Proteins

Native Disulphides

Modelled Disulphides

Total Disulphides

1

Non-redundant(April-2003)

2,849

2,170

147,722

149,892

2

Full database (April-2003)

19,612

31,657

2,353,960

2,385,617

Search is now available on PDB-April 2003 release also.
An option is provided on the search result page to filter the hits on the basis of user-defined sequence identity cut-off.


One of the potential uses of such a disulphide database is to design site-directed mutants in order to enhance the thermal stability of the protein in question. Another important application is to employ this database for proposing 3D models of disulphide-rich polypeptides like toxins and small proteins by searching for sub-structural motifs which are compatible with the derived disulphide bond connectivity. The user can obtain information about disulphide bonds of a particular protein of interest or probe the database for multiple disulphide bonded systems of particular connectivity. [More...]
  

Contact : R.Sowdhamini(mini@ncbs.res.in))
Group : Vinayagam A Ratna Rajesh T (ratna@ncbs.res.in) Pugalenthi G (pugal@ncbs.res.in)

Last modified : Mon June 9 09:01:02 IST 2003