SCOP Superfamily code |     | No of sequences |      | Superfamily name |
| 46458 |     |     14 |    | Globin-like |
| 46579 |     |     1 |    | Prefoldin |
| 46689 |     |     7 |    | Homeodomain-like |
| 46785 |     |     6 |    | "Winged helix" DNA-binding domain |
| 47095 |     |     2 |    | HMG-box |
| 47240 |     |     1 |    | Ferritin-like |
| 47266 |     |     42 |    | 4-helical cytokines |
| 47391 |     |     1 |    | Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit |
| 47413 |     |     1 |    | lambda repressor-like DNA-binding domains |
| 47459 |     |     4 |    | Helix-loop-helix DNA-binding domain |
| 47473 |     |     5 |    | EF-hand |
| 47616 |     |     1 |    | Glutathione S-transferase (GST), C-terminal domain |
| 47655 |     |     1 |    | STAT |
| 47719 |     |     1 |    | p53 tetramerization domain |
| 47769 |     |     2 |    | SAM/Pointed domain |
| 47874 |     |     1 |    | Annexin |
| 47943 |     |     2 |    | Retrovirus capsid protein, N-terminal core domain |
| 47986 |     |     1 |    | DEATH domain |
| 48092 |     |     1 |    | Transcription factor STAT-4 N-domain |
| 48179 |     |     2 |    | 6-phosphogluconate dehydrogenase C-terminal domain-like |
| 48239 |     |     5 |    | Terpenoid cylases/Protein prenyltransferases |
| 48264 |     |     6 |    | Cytochrome P450 |
| 48340 |     |     1 |    | Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain |
| 48403 |     |     1 |    | Ankyrin repeat |
| 48445 |     |     9 |    | 14-3-3 protein |
| 48479 |     |     1 |    | Cytochrome c oxidase subunit E |
| 48508 |     |     9 |    | Nuclear receptor ligand-binding domain |
| 48552 |     |     1 |    | Serum albumin-like |
| 48619 |     |     2 |    | Phospholipase A2, PLA2 |
| 49265 |     |     6 |    | Fibronectin type III |
| 49329 |     |     1 |    | Cu,Zn superoxide dismutase-like |
| 49417 |     |     3 |    | p53-like transcription factors |
| 49472 |     |     1 |    | Transthyretin (prealbumin) |
| 49503 |     |     2 |    | Cupredoxins |
| 49606 |     |     3 |    | Neurophysin II |
| 49723 |     |     1 |    | Lipase/lipooxygenase domain (PLAT/LH2 domain) |
| 49758 |     |     2 |    | Calpain large subunit, middle domain (domain III) |
| 49842 |     |     1 |    | TNF-like |
| 49879 |     |     4 |    | SMAD/FHA domain |
| 49899 |     |     3 |    | Concanavalin A-like lectins/glucanases |
| 50084 |     |     2 |    | Myosin S1 fragment, N-terminal domain |
| 50129 |     |     1 |    | GroES-like |
| 50156 |     |     2 |    | PDZ domain-like |
| 50242 |     |     1 |    | TIMP-like |
| 50249 |     |     1 |    | Nucleic acid-binding proteins |
| 50353 |     |     8 |    | Cytokine |
| 50494 |     |     10 |    | Trypsin-like serine proteases |
| 50630 |     |     12 |    | Acid proteases |
| 50729 |     |     1 |    | PH domain-like |
| 50814 |     |     5 |    | Lipocalins |
| 50911 |     |     1 |    | Mannose 6-phosphate receptor domain |
| 50923 |     |     3 |    | Hemopexin-like domain |
| 51069 |     |     5 |    | Carbonic anhydrase |
| 51197 |     |     1 |    | Clavaminate synthase-like |
| 51246 |     |     1 |    | Rudiment single hybrid motif |
| 51283 |     |     2 |    | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) |
| 51430 |     |     1 |    | NAD(P)-linked oxidoreductase |
| 51445 |     |     3 |    | (Trans)glycosidases |
| 51569 |     |     2 |    | Aldolase |
| 51604 |     |     1 |    | Enolase C-terminal domain-like |
| 51621 |     |     1 |    | Phosphoenolpyruvate/pyruvate domain |
| 51735 |     |     5 |    | NAD(P)-binding Rossmann-fold domains |
| 52042 |     |     1 |    | Ribosomal protein L32e |
| 52129 |     |     1 |    | Caspase-like |
| 52172 |     |     1 |    | CheY-like |
| 52218 |     |     1 |    | Flavoproteins |
| 52283 |     |     1 |    | Formate/glycerate dehydrogenase catalytic domain-like |
| 52343 |     |     2 |    | Ferredoxin reductase-like, C-terminal NADP-linked domain |
| 52490 |     |     1 |    | Tubulin, GTPase domain |
| 52540 |     |     1 |    | P-loop containing nucleotide triphosphate hydrolases |
| 52833 |     |     3 |    | Thioredoxin-like |
| 53223 |     |     1 |    | Aminoacid dehydrogenase-like, N-terminal domain |
| 53254 |     |     1 |    | Phosphoglycerate mutase-like |
| 53383 |     |     3 |    | PLP-dependent transferases |
| 53448 |     |     1 |    | Nucleotide-diphospho-sugar transferases |
| 53474 |     |     2 |    | alpha/beta-Hydrolases |
| 53613 |     |     1 |    | Ribokinase-like |
| 53720 |     |     1 |    | ALDH-like |
| 53756 |     |     2 |    | UDP-Glycosyltransferase/glycogen phosphorylase |
| 53822 |     |     1 |    | Periplasmic binding protein-like I |
| 53955 |     |     7 |    | Lysozyme-like |
| 54001 |     |     1 |    | Cysteine proteinases |
| 54076 |     |     2 |    | RNase A-like |
| 54098 |     |     3 |    | Prion-like |
| 54117 |     |     4 |    | Interleukin 8-like chemokines |
| 54236 |     |     1 |    | Ubiquitin-like |
| 54292 |     |     1 |    | 2Fe-2S ferredoxin-like |
| 54403 |     |     2 |    | Cystatin/monellin |
| 54452 |     |     28 |    | MHC antigen-recognition domain |
| 54556 |     |     2 |    | Chitinase insertion domain |
| 55008 |     |     2 |    | Metal-binding domain |
| 55307 |     |     2 |    | Tubulin, C-terminal domain |
| 55486 |     |     1 |    | Metalloproteases ("zincins"), catalytic domain |
| 55550 |     |     1 |    | SH2 domain |
| 55729 |     |     2 |    | Acyl-CoA N-acyltransferases (Nat) |
| 55961 |     |     2 |    | Bet v1-like |
| 55979 |     |     1 |    | DNA clamp |
| 56059 |     |     1 |    | Glutathione synthetase ATP-binding domain-like |
| 56112 |     |     10 |    | Protein kinase-like (PK-like) |
| 56219 |     |     1 |    | DNase I-like |
| 56327 |     |     1 |    | Lactate & malate dehydrogenases, C-terminal domain |
| 56366 |     |     1 |    | SMAD MH1 domain |
| 56436 |     |     3 |    | C-type lectin-like |
| 56487 |     |     8 |    | Scavenger receptor cysteine-rich (SRCR) domain |
| 56512 |     |     2 |    | Nitric oxide (NO) synthase oxygenase domain |
| 56574 |     |     5 |    | Serpins |
| 56655 |     |     1 |    | Sugar phosphatases |
| 56752 |     |     2 |    | D-aminoacid aminotransferase-like PLP-dependent enzymes |
| 56784 |     |     2 |    | HAD-like |
| 56854 |     |     4 |    | Bcl-2 inhibitors of programmed cell death |
| 56994 |     |     2 |    | Insulin-like |
| 57184 |     |     4 |    | Growth factor receptor domain |
| 57196 |     |     4 |    | EGF/Laminin |
| 57302 |     |     2 |    | Snake toxin-like |
| 57362 |     |     5 |    | BPTI-like |
| 57392 |     |     2 |    | Defensin-like |
| 57440 |     |     5 |    | Kringle-like |
| 57467 |     |     2 |    | Ovomucoid/PCI-1 like inhibitors |
| 57501 |     |     13 |    | Cystine-knot cytokines |
| 57535 |     |     3 |    | Complement control module/SCR domain |
| 57552 |     |     1 |    | Blood coagulation inhibitor (disintegrin) |
| 57593 |     |     3 |    | Heparin-binding domain from vascular endothelial growth factor |
| 57610 |     |     4 |    | Thyroglobulin type-1 domain |
| 57667 |     |     2 |    | C2H2 and C2HC zinc fingers |
| 57716 |     |     3 |    | Glucocorticoid receptor-like (DNA-binding domain) |
| 57756 |     |     2 |    | Retrovirus zinc finger-like domains |
| 57868 |     |     3 |    | Metallothionein |
| 63380 |     |     2 |    | Riboflavin synthase domain-like |
| 64546 |     |     1 |    | Satiety factor CART (cocaine and amphetamine regulated transcript) |
| 69179 |     |     1 |    | Integrin domains |
| 69687 |     |     1 |    | Integrin beta tail domain |
| 81296 |     |     2 |    | E set domains |
| 81653 |     |     1 |    | Calcium ATPase, transduction domain A |
| 81660 |     |     1 |    | Calcium ATPase, ATP-binding domain N |