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Single Member Superfamies:

superfamily code   No of members    Average size     Superfamily name 


46557               1                78          GreA transcript cleavage protein, N-terminal domain
46561               1                65          Ribosomal protein L29 (L29p)
46575               1                76          Theta subunit of DNA polymerase III
46585               1                86          Effector domain of the protein kinase pkn/prk1
46596               1                72          Eukaryotic DNA topoisomerase I, dispensable insert domain
46600               1                56          C-terminal UvrC-binding domain of UvrB
46906               1                70          Ribosomal protein L11, C-terminal domain
46911               1                73          Ribosomal protein S18
46915               1                83          Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
46919               1                46          N-terminal Zn binding domain of HIV integrase
46924               1                65          RNA polymerase subunit RPB10
46938               1                93          N-terminal domain of phosphatidylinositol transfer protein sec14p
46942               1               114          Elongation factor TFIIS domain 2
46946               1               125          S13-like H2TH domain
46950               1                72          Hypothetical protein MTH1615
46973               1               102          Enzyme IIa from lactose specific PTS, IIa-lac
46984               1               157          Smac/diablo
46988               1               102          Tubulin chaperone cofactor A
46992               1                99          Ribosomal protein S20
47040               1                81          Kix domain of CBP (creb binding protein)
47045               1                81          alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
47050               1                36          Thermostable subdomain from chicken villin headpiece
47055               1                67          TAF(II)230 TBP-binding fragment
47072               1                68          p8-MTCP1
47077               1               137          T4 endonuclease V
47144               1                95          HSC20 (HSCB), C-terminal oligomerisation domain
47148               1               137          Diol dehydratase, gamma subunit
47152               1               162          Methane monooxygenase hydrolase, gamma subunit
47157               1                95          Mitochondrial import receptor subunit Tom20
47162               1               132          Apolipoprotein
47170               1               157          Aspartate receptor, ligand-binding domain
47188               1               118          Hemerythrin
47212               1                94          FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
47216               1               200          Proteasome activator reg(alpha)
47345               1                83          Colicin E immunity proteins
47380               1                59          ROP protein
47391               1                46          Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit
47401               1                37          Ectatomin, A & B chains
47454               1                74          A DNA-binding domain in eukaryotic transcription factors
47587               1               135          Domain of poly(ADP-ribose) polymerase
47592               1                88          MDM2
47644               1                90          Methionine synthase domain
47648               1                70          Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
47655               1               177          STAT
47668               1               131          N-terminal domain of cbl (N-cbl)
47672               1               148          Transferrin receptor ectodomain, C-terminal domain
47676               1                77          Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
47681               1                91          C-terminal domain of B transposition protein
47686               1                65          Anaphylotoxins (complement system)
47694               1                79          Cytochrome c oxidase subunit h
47719               1                31          p53 tetramerization domain
47724               1                90          Domain of early E2A DNA-binding protein, ADDBP
47752               1                79          Protein HNS-dependent expression A; HdeA
47757               1                81          Chemotaxis receptor methyltransferase CheR, N-terminal domain
47762               1                89          PAH2 domain
47794               1                70          DNA repair protein Rad51, N-terminal domain
47798               1                87          Barrier-to-autointegration factor, BAF
47831               1               123          Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain
47852               1               142          Hepatitis B viral capsid (hbcag)
47869               1                70          Bacteriocin AS-48
47912               1               107          Wiscott-Aldrich syndrome protein, WASP, C-terminal domain
47928               1               105          N-terminal domain of the delta subunit of the F1F0-ATP synthase
47933               1               106          Endoplasmic reticulum protein ERP29, C-domain
47938               1               149          Functional domain of the splicing factor Prp18
47979               1                80          Iron-dependent represor protein, dimerization domain
48008               1               152          Fatty acid responsive transcription factor FadR, C-terminal domain
48024               1               102          N-terminal domain of DnaB helicase
48029               1               101          FliG
48045               1               143          Scaffolding protein gpD of bacteriophage procapsid
48076               1               132          LigA subunit of an aromatic-ring-opening dioxygenase LigAB
48092               1               124          Transcription factor STAT-4 N-domain
48108               1               153          Carbamoyl phosphate synthetase, large subunit connection domain
48140               1               143          Ribosomal protein L19 (L19e)
48145               1               158          Influenza virus matrix protein M1
48163               1               163          An anticodon-binding domain of class I aminoacyl-tRNA synthetases
48168               1               212          R1 subunit of ribonucleotide reductase, N-terminal domain
48201               1                70          Uteroglobin-like
48295               1               101          TrpR-like
48300               1                57          Ribosomal protein L7/12, oligomerisation (N-terminal) domain
48305               1                75          MHC class II-associated invariant chain ectoplasmic trimerization domain
48329               1               305          RNA polymerase sigma subunit
48340               1               300          Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain
48366               1               439          Ras GEF
48425               1               195          Sec7 domain
48435               1               450          Bacterial muramidases
48445               1               228          14-3-3 protein
48473               1               263          Phosphoinositide-binding clathrin adaptor, N-terminal domain
48479               1               109          Cytochrome c oxidase subunit E
48493               1               217          gene 59 helicase assembly protein
48547               1               351          Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b
48608               1               156          Peridinin-chlorophyll protein
48647               1                99          Fungal elicitin
48652               1                90          Tetraspanin
48657               1               152          Repressor of bacterial conjugation FinO
48662               1                46          Ribosomal protein L39e
48666               1                57          Methanol dehydrogenase subunit
48674               1                88          Fe-only hydrogenase smaller subunit
48678               1                87          Moesin tail domain
48682               1                32          Nuclear receptor coactivator Src-1
48686               1                29          Proteinase A inhibitor IA3
48690               1                47          Epsilon subunit of mitochondrial F1F0-ATP synthase
49299               1                80          PKD domain
49363               1               112          Purple acid phosphatase, N-terminal domain
49380               1               161          Diphtheria toxin, C-terminal domain
49410               1               130          Alpha-macroglobulin receptor domain
49441               1               187          Cytochrome f, large domain
49447               1               256          Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor
49464               1                79          Carboxypeptidase D, a regulatory domain
49468               1               142          VHL
49472               1               115          Transthyretin (prealbumin)
49498               1                74          alpha-Amylase inhibitor tendamistat
49590               1                94          PHL pollen allergen
49594               1               110          Rab geranylgeranyltransferase alpha-subunit, insert domain
49606               1                85          Neurophysin II
49758               1               142          Calpain large subunit, middle domain (domain III)
49772               1               131          Ecotin, trypsin inhibitor
49830               1               228          F-MuLV receptor-binding domain
49870               1               207          Osmotin, thaumatin-like protein
49889               1               224          Soluble secreted chemokine inhibitor, VCCI
49894               1               299          Paculovirus p35
49994               1               293          beta-Galactosidase, domain 5
50012               1               260          EV matrix protein
50017               1               288          gp9
50118               1               101          Cell growth inhibitor/plasmid maintainance toxic component
50151               1                55          SacY-like RNA-binding domain
50199               1               137          Staphylococcal nuclease
50443               1               236          L-fucose isomerase, C-terminal domain
50610               1                80          mu transposase, C-terminal domain
50723               1               125          Core binding factor beta, CBF
50809               1               113          XRCC4, N-terminal domain
50934               1               235          Tachylectin-2
50952               1               448          Soluble quinoprotein glucose dehydrogenase
50956               1               353          Thermostable phytase (3-phytase)
50960               1               263          TolB, C-terminal domain
50965               1               386          Galactose oxidase, central domain
50974               1               441          Nitrous oxide reductase, N-terminal domain
50989               1               328          Clathrin heavy-chain terminal domain
50993               1               426          Prolyl oligopeptidase, N-terminal domain
51004               1               432          C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase
51064               1                59          Head domain of nucleotide exchange factor GrpE
51081               1               350          Bacteriochlorophyll A protein
51087               1               251          Outer surface protein A
51092               1               163          Vitelline membrane outer protein-I (VMO-I)
51110               1               119          alpha-D-mannose-specific plant lectins
51120               1               224          Serralysin-like metalloprotease, C-terminal domain
51156               1                82          Insect cysteine-rich antifreeze protein
51177               1                90          An insect antifreeze protein
51215               1               166          Regulatory protein AraC
51219               1                68          Trp RNA-binding attenuation protein (TRAP)
51261               1               158          Duplicated hybrid motif
51269               1                67          Type III antifreeze protein
51274               1                95          Head decoration protein D (gpD, major capsid protein D)
51278               1               122          Urease, beta-subunit
51289               1               102          ACMNPV telokin-like protein
51322               1               103          Cyanovirin-N
51327               1               104          Head-binding domain of phage P22 tailspike protein
51391               1               226          Thiamin phosphate synthase
51645               1               688          Malate synthase G
51690               1               169          Quinolinic acid phosphoribosyltransferase, C-terminal domain
51713               1               372          tRNA-guanine transglycosylase
51730               1               275          FAD-linked oxidoreductase
51984               1                93          MurCD N-terminal domain
52016               1               226          Aconitase
52021               1               151          Carbamoyl phosphate synthetase, small subunit N-terminal domain
52025               1               193          Transferrin receptor ectodomain, apical domain
52038               1                90          Barstar (barnase inhibitor)
52042               1               142          Ribosomal protein L32e
52075               1               198          Outer arm dynein light chain 1
52087               1               203          C-terminal domain of phosphatidylinositol transfer protein sec14p
52151               1               125          FabD/lysophospholipase-like
52156               1               131          Initiation factor IF2/eIF5b, domain 3
52161               1               142          Ribosomal protein L13
52200               1               159          Toll/Interleukin receptor TIR domain
52206               1               111          Hypothetical protein MTH538
52251               1               105          Ornithine decarboxylase N-terminal "wing" domain
52255               1               158          N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) mutase PurE
52279               1               215          Beta-D-glucan exohydrolase, C-terminal domain
52304               1               136          Type II 3-dehydroquinate dehydratase
52309               1               156          Nucleoside 2-deoxyribosyltransferase
52313               1               237          Ribosomal protein S2
52413               1               108          UDP-glucose dehydrogenase (UDPGDH), C-terminal (UDP-binding) domain
52418               1               260          Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain
52512               1               266          Phosphosugar isomerase
52728               1               161          Fructose permease, subunit IIb
52733               1               346          Nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT)
52738               1               198          Methylesterase CheB, C-terminal domain
52794               1               103          Enzyme IIB-cellobiose
52913               1                95          RNA 3'-terminal phosphate cyclase, RPTC, insert domain
52949               1               159          Leucine aminopeptidase (Aminopeptidase A), N-terminal domain
52964               1               134          TolB, N-terminal domain
52968               1               178          B12-dependend dehydatases associated subunit
53032               1                97          tRNA splicing endonuclease, C-terminal domain
53036               1               139          Eukaryotic RPB5 N-terminal domain
53062               1               129          IIA domain of mannose transporter, IIA-Man
53146               1               124          MTH1175-like
53178               1               193          Peptidyl-tRNA hydrolase
53213               1               298          LigB subunit of an aromatic-ring-opening dioxygenase LigAB
53323               1               253          Pyruvate-ferredoxin oxidoreductase, PFOR, domain III
53633               1               313          Carbamate kinase-like
53644               1               504          Cytosolic phospholipase A2 catalytic
53732               1               527          Aconitase iron-sulfur domain
53743               1               355          L-fucose isomerase, N-terminal and second domains
53774               1               337          Glutaminase/Asparaginase
53784               1               320          Phosphofructokinase
53790               1               239          Cobalt precorrin-4 methyltransferase CbiF
53920               1               321          Fe-only hydrogenase
54106               1                48          LysM domain
54111               1               100          Urease, gamma-subunit
54364               1                76          Translation initiation factor IF3, N-terminal domain
54368               1               100          Glutamine synthetase, N-terminal domain
54423               1                60          Disulfide bond isomerase, DsbC, N-terminal domain
54441               1                85          Uracil-DNA glycosylase inhibitor protein
54447               1                66          ssDNA-binding transcriptional regulator domain
54518               1               265          Transcriptional factor tubby, C-terminal domain
54529               1               182          Acidic mitochondrial matrix protein p32
54552               1                84          Colicin E3 immunity protein
54565               1                83          Ribosomal protein S16
54570               1                84          Ribosomal protein S19
54575               1                82          Ribosomal protein L31e
54580               1                67          Allophycocyanin linker chain (domain)
54611               1               143          Bacterial protein-export protein SecB
54616               1                99          DNA-binding domain of Mlu1-box binding protein MBP1
54621               1               173          Heme-binding protein A (HasA)
54626               1               212          Chalcone isomerase
54648               1                85          Dynein light chain 8 (DLC8)
54686               1               156          Ribosomal protein L10e
54690               1               142          Molybdopterin synthase subunit MoaE
54736               1                68          ClpS-like
54742               1                53          Transcription-state regulator AbrB, the N-terminal DNA recognition domain
54747               1                63          Ribosomal protein L11, N-terminal domain
54752               1                60          RecA protein, C-terminal domain
54782               1                88          Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain
54786               1                79          PI-Pfui intein middle domain
54810               1               121          GMP synthetase C-terminal dimerisation domain
54821               1               101          Ribosomal protein S3 C-terminal domain
54857               1                81          DNA damage-inducible protein DinI
54893               1               100          Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domain
54909               1                96          Dimeric alpha+beta barrel
54913               1               112          GlnB-like
54919               1               150          Nucleoside diphosphate kinases
54975               1                98          Acylphosphatase-like
54991               1               104          Anticodon-binding domain of PheRS
54995               1                97          Ribosomal protein S6
54999               1                98          Ribosomal protein S10
55031               1               113          Bacterial exopeptidase dimerisation domain
55040               1               143          Molybdenum cofactor biosynthesis protein C, MoaC
55044               1               158          TRADD, N-terminal domain
55048               1                70          Probable ACP-binding domain of malonyl-CoA ACP transacylase
55052               1                68          CheY-binding domain of CheA
55056               1                79          Killer toxin KP6 alpha-subunit
55064               1               122          Translational regulator protein regA
55068               1               189          Peptide methionine sulfoxide reductase
55083               1               158          6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK
55144               1               181          tRNA splicing product Appr>p cyclic nucleotide phosphodiesterase
55149               1               127          Pepsin inhibitor-3
55154               1               288          mRNA triphosphatase CET1
55186               1               179          Threonyl-tRNA synthetase (ThrRS), second 'additional' domain
55200               1                88          Translation initiation factor IF3, C-terminal domain
55216               1                91          C-terminal domain of TolA
55229               1                58          Cell division protein MinE topological specificity domain
55234               1                68          Cyanase C-terminal domain
55248               1                99          Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH)
55267               1                74          tRNA splicing endonuclease EdnA, N-terminal domain
55277               1                62          GYF domain
55326               1               166          Aminoimidazole ribonucleotide synthetase (PurM) N-terminal domain
55383               1                86          Copper amine oxidase, domain N
55399               1               107          Subtilisin inhibitor
55481               1               138          N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1
55604               1                78          Glucose permease domain IIB
55637               1               101          Cell cycle regulatory proteins
55648               1               165          beta-lactamase-inhibitor protein, BLIP
55653               1                94          Ribosomal protein L9 C-domain
55671               1               104          Regulatory factor Nef
55676               1               227          Mosquitocidal delta-endotoxin CytB
55724               1               189          Ran-binding protein mog1p
55781               1               176          GAF domain-like
55816               1               188          5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain
55826               1               150          Hypothetical protein HI1434 (YbaK homologue)
55846               1               146          N-acetylmuramoyl-L-alanine amidase-like
55869               1                77          DNA topoisomerase I domain
55890               1               168          Sporulation responce regulatory protein Spo0B
55904               1               161          Ornithine decarboxylase C-terminal domain
55957               1               141          Phosphoglucomutase, C-terminal domain
56019               1               197          The spindle assembly checkpoint protein mad2
56037               1               209          B3/B4 domain of PheRS, PheT
56042               1               175          Aminoimidazole ribonucleotide synthetase (PurM) C-terminal domain
56199               1               316          Methenyltetrahydromethanopterin cyclohydrolase
56204               1               350          Ubiquitin-protein ligase E3a, Hect catalytic domain (E6ap)
56209               1               192          Nitrile hydratase alpha chain
56228               1               210          Aldehyde ferredoxin oxidoreductase, N-terminal domain
56266               1               363          L-aminopeptidase D-Ala-esterase/amidase
56271               1               309          Histidine decarboxylase
56276               1               309          S-adenosylmethionine decarboxylase
56295               1               363          Protein serine/threonine phosphatase 2
56366               1               123          SMAD MH1 domain
56420               1               164          Peptide deformylase
56487               1               112          Scavenger receptor cysteine-rich (SRCR) domain
56491               1                96          A heparin-binding domain
56502               1               305          gp120 core
56507               1               327          Methionine synthase activation domain-like
56512               1               416          Nitric oxide (NO) synthase oxygenase domain
56519               1                82          Penicillin binding protein dimerisation domain
56524               1               250          Sulfite oxidase, middle catalytic domain
56534               1               308          Aromatic aminoacid monoxygenases, catalytic and oligomerization domains
56548               1               311          Conserved core of transcriptional regulatory protein vp16
56558               1               208          Baseplate structural protein gp11
56563               1               280          Major capsid protein gp5
56596               1               305          Replication terminator protein (Tus)
56629               1               250          ADP ribosyl cyclase-like
56726               1               289          DNA topoisomerase IV, alpha subunit
56731               1               310          DNA primase DnaG catalytic core
56736               1               266          DNA repair protein MutM (Fpg)
56741               1               220          Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment
56747               1               344          DNA primase
56770               1               267          Nickel-iron hydrogenase, small subunit
56778               1               215          Heat shock protein 70kD (HSP70), C-terminal substrate-binding fragment
56815               1               527          Sec1/munc18-like (SM) proteins
56826               1               249          Upper collar protein gp10 (connector protein)
56831               1               845          BTV inner layer core protein vp3
56845               1               181          Diphtheria toxin, middle domain
56864               1               143          Exotoxin A, middle domain
56931               1               253          Outer membrane phospholipase A (OMPLA)
56954               1               423          Integral outer membrane protein TolC, efflux pump component
56973               1               366          (Pro)aerolysin, pore-forming lobe
56978               1               471          Perfringolysin
56983               1               302          Viral glycoprotein, central and dimerisation domains
56988               1               665          Anthrax protective antigen
57007               1                48          Heat-stable enterotoxin B
57011               1                54          Neurotoxin B-IV
57055               1                46          Agouti-related protein
57180               1                36          Cellulose-binding domain
57256               1                47          Elafin-like
57277               1                30          Granulin repeat
57296               1                40          Amb V allergen
57419               1                27          Neurotoxin III (ATX III)
57561               1               125          Methylamine dehydrogenase, L chain
57581               1                74          TB module/8-cys domain
57593               1                55          Heparin-binding domain from vascular endothelial growth factor
57598               1                51          Antifungal protein (AGAFP)
57610               1                65          Thyroglobulin type-1 domain
57615               1                50          Type X cellulose binding domain, CBDX
57620               1                61          Carboxypeptidase inhibitor
57625               1                73          Tachycitin
57642               1                47          Cholecystokinin A receptor, N-domain
57647               1                45          HIV-1 VPU cytoplasmic domain
57662               1               109          Ferredoxin thioredoxin reductase (FTR), catalytic beta chain
57770               1                35          Methionyl-tRNA synthetase (MetRS), Zn-domain
57798               1               159          Casein kinase II beta subunit
57821               1                71          Hypothetical protein MTH1184
57825               1                53          Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain
57840               1                37          Ribosomal protein L36
57845               1                39          B-box zinc-binding domain
57863               1               122          Pyk2-associated protein beta ARF-GAP domain
57879               1                42          Zinc domain conserved in yeast copper-regulated transcription factors
57884               1                92          Ada DNA repair protein, N-terminal domain (N-Ada 10)
57933               1                87          TAZ domain
57938               1                79          Cysteine-rich domain of the chaperone protein DnaJ.
63433               1               118          Fumarylacetoacetate hydrolase, FAH, N-terminal domain
63446               1                71          Type I dockerin domain
63491               1               112          BAG domain
63501               1               122          Frizzled cystein-rich domain
63515               1               162          Outer surface protein C (OspC)
63562               1                98          RNA polymerase omega subunit
63592               1                98          Flagellar transcriptional activator FlhD
63697               1               157          Olfactory marker protein
63707               1               160          Ganglioside M2 (gm2) activator
63712               1               205          Nicotinic receptor ligand binding domain-like
63724               1               175          Equinatoxin II (eqtII, tenebrosin C)
63732               1               267          Lactobacillus maltose phosphorylase, N-terminal domain
63737               1               208          Leukotriene A4 hydrolase N-terminal domain
63763               1                95          SAND domain-like
63817               1               148          Sortase
63825               1               258          Low density lipoprotein (LDL) receptor YWTD domain
63829               1               312          Diisopropylfluorophosphatase (phosphotriesterase, DFP)
63840               1                96          Ribonuclease domain of colicin E3
63848               1               107          Cell-division inhibitor MinC, C-terminal domain
63867               1                83          Molybdenum cofactor biosynthesis protein MoeA, C-terminal domain
63877               1               188          Methuselah ectodomain
63882               1               171          Molybdenum cofactor biosynthesis protein MoeA, N-terminal and linker domains
63887               1               101          P-domain of calnexin/calreticulin
63892               1               235          Pyridoxine 5'-phosphate synthase
63965               1               209          Precorrin-8x methylmutase
63992               1               274          Dipeptide transport protein
64043               1                89          Cell-division inhibitor MinC, N-terminal domain
64076               1               111          Hypothetical protein MT938 (MTH938)
64153               1               240          YjeF N-terminal domain-like
64158               1               234          2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain
64167               1               247          SurE-like
64182               1               310          DHH phosphoesterases
64197               1               386          AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC
64210               1                58          Head-to-tail joining protein W, gpW
64234               1               138          Photosystem I subunit PsaD
64263               1               105          Prokaryotic ribosomal protein L17
64288               1               164          Chorismate lyase
64325               1                73          Dimeric C-terminal domain of membrane protein TonB 
64376               1                98          YlxR-like
64383               1               139          Cell-division protein ZipA, C-terminal domain
64397               1               229          Hsp33 domain
64438               1               295          Type 1 cytotoxic necrotizing factor, catalytic domain
64449               1               123          YopH tyrosine phosphatase N-terminal domain
64465               1               365          Outer capsid protein sigma 3
64496               1                96          DNA-binding domain of intron endonuclease I-TevI
64518               1               395          F41 fragment of flagellin
64546               1                41          Satiety factor CART (cocaine and amphetamine regulated transcript)
64571               1                46          Cellulose docking domain, dockering
64586               1                74          C-terminal domain of ProRS
68912               1                44          Rho termination factor, N-terminal domain
68918               1                57          Recombination endonuclease VII, C-terminal and dimerization domains
68930               1               104          Protein-L-isoaspartyl O-methyltransferase, C-terminal domain
68989               1                72          Hemolysin expression modulating protein HHA
68993               1               142          FAT domain of focal adhesion kinase
69000               1               105          Thiol oxidase Erv2p
69008               1                99          RecG, N-terminal domain
69025               1                84          Hypothetical protein MTH865
69036               1                64          Bcr-Abl oncoprotein oligomerization domain
69047               1                69          Hypothetical protein YjbJ
69055               1                98          1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain
69060               1               174          Arp2/3 complex 21 kDa subunit ARPC3
69065               1               148          RNase III endonuclease catalytic domain
69070               1                90          Anti-sigma factor AsiA
69075               1               104          Glutamyl tRNA-reductase dimerization domain
69099               1               156          Ran-GTPase activating protein 1 (RanGAP1), C-terminal domain
69103               1               139          Arp2/3 complex 16 kDa subunit ARPC5
69118               1               174          Antioxidant defence protein AhpD
69131               1                76          Quinohemoprotein amine dehydrogenase C chain
69189               1                94          Penicillin-binding protein 5, C-terminal domain
69203               1                94          Nucleoplasmin core
69255               1               124          Tail-associated lysozyme gp5, N-terminal domain
69304               1               281          Tricorn protease N-terminal domain
69318               1               438          Integrin alpha N-terminal domain
69322               1               360          Tricorn protease N-terminal domain
69336               1               270          Alpha subunit of glutamate synthase, C-terminal domain
69340               1               156          C-terminal domain of adenylylcyclase associated protein
69360               1                92          Choline binding domain of autolysin C-LytA
69369               1               232          Colicin E3 translocation domain
69500               1               145          D-Tyr tRNAtyr deacylase
69572               1               240          Molybdenum cofactor biosynthesis protein MoeB
69593               1               363          Glycerol-3-phosphate (1)-acyltransferase
69618               1               260          Uroporphyrinogen III synthase (U3S, HemD)
69652               1               108          DNA-binding C-terminal domain of the transcription factor MotA
69687               1                85          Integrin beta tail domain
69695               1               114          SRP19
69721               1               111          DsrC, the gamma subunit of dissimilatory sulfite reductase
69732               1                80          Lrp/AsnC-like transcriptional regulator C-terminal domain
69742               1               148          Glutamyl tRNA-reductase catalytic, N-terminal domain
69754               1               107          Ribosome binding protein Y (YfiA homologue)
69761               1                83          GTP cyclohydrolase I feedback regulatory protein, GFRP
69765               1               155          2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase IspF
69786               1               104          YggU-like
69796               1               199          Thymidylate synthase-complementing protein Thy1
69819               1               140          MTH1598-like
69848               1               100          LCCL domain
69864               1               256          Argininosuccinate synthetase, C-terminal domain
69898               1               988          Golgi alpha-mannosidase II
69903               1               154          NSP3 homodimer
69908               1               641          Membrane penetration protein mu1
69917               1               297          OMPT-like
69922               1               266          Head and neck region of the ectodomain of NDV fusion glycoprotein
69959               1                55          Serine proteinase inhibitor lekti, domain one
69964               1                51          Pheromone ER-23
74731               1                60          Ribosomal protein L20
74748               1               269          Variable surface antigen VlsE
74778               1               160          Aconitase B, N-terminal domain
74784               1               212          Testis/brain RNA-binding protein (TB-RBP)
74788               1               359          Culin repeat
74800               1                51          C-terminal activation domain (CTAD) of HIF-1alpha
74853               1               113          Lamin A/C globular tail domain
74863               1               121          Thiol:disulfide interchange protein DsbD, N-terminal domain
74914               1               370          V-region of surface antigen I/II (SA I/II, PAC)
74924               1                95          Cap-Gly domain
74942               1                74          YhbC-like, C-terminal domain
74982               1               133          Small protein B (SmpB)
75001               1               119          Dipeptidyl peptidase I (cathepsin C), exclusion domain
75005               1               318          alpha-L-arabinanase
75011               1               355          3-carboxy-cis,cis-mucoante lactonizing enzyme
75098               1               457          Monomethylamine methyltransferase MtmB
75138               1               129          HPr kinase/phoshatase HprK N-terminal domain
75169               1               108          YchN-like
75181               1               148          Hypothetical protein MTH777 (MT0777)
75304               1               412          Amidase signature (AS) enzymes
75347               1               170          Rotavirus NSP2 fragment, C-terminal domain
75404               1               163          VSV matrix protein
75412               1                88          Hypothetical protein MTH1880
75420               1                90          YhbC-like, N-terminal domain
75445               1                69          D-ribose-5-phosphate isomerase (RpiA), lid domain
75471               1                98          YhbY-like
75500               1               103          Putative transcriptional regulator TM1602, C-terminal domain
75516               1               167          Pheromone-binding domain of LuxR-like quorum-sensing transcription factors
75553               1               161          Smc hinge domain
75569               1               202          Hypothetical protein MTH1020
75574               1               143          Rotavirus NSP2 fragment, N-terminal domain
75604               1               222          Archaeosine tRNA-guanine transglycosylase, C-terminal additional domains
75615               1               120          Bifunctional dehydrogenase/ferrochelatase Met8p, dimerisation and C-terminal domains
75620               1               354          Polypeptide chain release factor 2 (RF2)
75625               1               241          YebC-like
75632               1               276          Culin homology domain
75704               1                87          Mitotic arrest deficient-like 1, Mad1
75708               1               177          Chemotaxis phosphatase CheZ
75712               1               103          Rad50 coiled-coil Zn hook
81277               1               101          C-terminal domain of octopus hemocyanin
81382               1                55          Skp1 dimerisation domain-like
81601               1                68          Protein serine/threonine phosphatase 2C, C-terminal domain
81606               1               295          Protein serine/threonine phosphatase 2C, catalytic domain
81631               1               260          Poly(A) polymerase, middle domain
81653               1               870          Calcium ATPase, transduction domain A
81660               1               634          Calcium ATPase, ATP-binding domain N
81698               1                69          FF domain
81710               1                87          Plasmid maintenance system epsilon/zeta, antidote epsilon subunit
81730               1                65          beta-catenin-interacting protein ICAT
81736               1               104          Pollen allergen Phl P 6
81761               1               763          X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal domain
81767               1               576          Pre-protein croslinking domain of SecA
81778               1                78          Crustacean CHH/MIH/GIH neurohormone
81783               1                62          C-terminal domain of DFF45/ICAD (DFF-C domain)
81790               1                85          Myosin phosphatase inhibitor 17kDa protein, CPI-17
81799               1               178          Putative methyltransferase TM0872, insert domain
81822               1               176          RuBisCo LSMT C-terminal, substrate-binding domain
81827               1               173          Porin chaperone SurA, peptide-binding domain
81832               1               165          GEF domain of SopE toxin
81837               1               300          BEACH domain
81853               1               324          Family 10 polysaccharide lyase
81872               1               591          BRCA2 helical domain
81878               1               250          BRCA2 tower domain
81886               1               232          Helical scaffold and wing domains of SecA
81891               1               259          tRNA CCA-adding enzyme, C-terminal domains
81901               1               133          Cysteine rich protein B (HcpB)
81930               1               316          Orange carotenoid protein, N-terminal domain
81935               1               514          N-terminal domain of bifunctional PutA protein
81982               1               131          Antigen MPT63/MPB63 (immunoprotective extracellular protein)
82004               1               136          N-utilization substance G protein NusG, insert domain
82026               1               120          Fucose-binding lectin II (PA-IIL)
82046               1               371          Viral chemokine binding protein m3
82051               1               332          Obg GTP-binding protein N-terminal domain
82061               1               203          BAH domain
82093               1               100          Heme chaperone CcmE
82109               1               292          IP3 receptor type 1 binding core, domain 1
82114               1               154          Riboflavin kinase
82171               1               726          Dipeptidyl peptidase IV/CD26, N-terminal domain
82185               1               293          Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain
82215               1               158          C-terminal autoproteolytic domain of nucleoporin nup98
82220               1               408          Tp47 lipoprotein, N-terminal domain
82282               1               348          Betaine-homocysteine S-methyltransferase
82317               1               516          Swiveling domain of the glycerol dehydratase reactivase alpha subunit
82544               1               414          Putative glycerate kinase (hypothetical protein TM1585)
82549               1               270          DegV-like
82602               1               143          Nuclease A inhibitor (NuiA)
82607               1                85          YbaB-like
82615               1                75          Polo domain
82649               1               140          SufE (YhnA)
82653               1                81          Probable GTPase Der, C-terminal domain
82657               1               113          BolA-like
82671               1               132          SEA domain
82679               1               101          N-utilization substance G protein NusG, N-terminal domain
82689               1               101          Mechanosensitive channel protein MscS (YggB), C-terminal domain
82697               1                76          PurS subunit of FGAM synthetase
82704               1                89          DNA-binding protein Sso10b (AlbA)
82708               1                62          R3H domain
82771               1                97          GIY-YIG endonuclease
82784               1               142          Ohr/OsmC resistance proteins
82808               1               118          Replication modulator SeqA, C-terminal DNA-binding domain
82829               1               203          Putative cell cycle protein MesJ, middle and C-terminal domain
82895               1               113          TSP-1 type 1 repeat
82910               1               110          Apical membrane antigen 1
82927               1                52          Cysteine-rich DNA binding domain, (DM domain)
82931               1               105          Tumor suppressor gene product Apc
82936               1                74          Apolipoprotein A-II

Superfamily code   No of members    Average size     Superfamily name 


46458              26               144          Globin-like
46548               3               151          alpha-helical ferredoxin
46565               4                86          Chaperone J-domain
46579               2               118          Prefoldin
46589               2                94          tRNA-binding arm
46604               2                47          Epsilon subunit of F1F0-ATP synthase C-terminal domain
46609               4                88          Fe,Mn superoxide dismutase (SOD), N-terminal domain
46626              22               101          Cytochrome c
46689              32                64          Homeodomain-like
46767               2                82          Methylated DNA-protein cysteine methyltransferase, C-terminal domain
46774               2               117          ARID-like
46785              48                88          "Winged helix" DNA-binding domain
46894               6                92          C-terminal effector domain of the bipartite response regulators
46929               2                48          DNA helicase RuvA subunit, C-terminal domain
46934               3                56          UBA-like
46955               5                90          Putative DNA-binding domain
46966               7               147          Spectrin repeat
46977               4               145          Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
46997               2                58          Bacterial immunoglobulin/albumin-binding domains
47005               2                39          Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
47014               3                39          Protozoan pheromone proteins
47027               2               290          Acyl-CoA binding protein
47031               2               108          Second domain of FERM
47060               3                70          S15/NS1 RNA-binding domain
47082               2               134          Fertilization protein
47090               2                80          PGBD-like
47095               6                83          HMG-box
47113              12                88          Histone-fold
47175               6               123          Cytochromes
47195               2               159          TMV-like viral coat proteins
47203               2               152          Acyl-CoA dehydrogenase C-terminal domain-like
47220               4               150          alpha-catenin/vinculin
47226               3               136          Histidine-containing phosphotransfer domain, HPT domain
47233               3               126          Bacterial GAP domain
47240              12               259          Ferritin-like
47266              22               142          4-helical cytokines
47323               7               185          Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
47336               4                78          ACP-like
47353               3                76          Retrovirus capsid protein C-terminal domain
47364               3               258          Domain of the SRP/SRP receptor G-proteins
47370               4               120          Bromodomain
47384               2                64          Homodimeric domain of signal transducing histidine kinase
47396               2                48          Transcription factor IIA (TFIIA), N-terminal domain
47406               3                32          SinR repressor dimerisation domain-like
47413              10                70          lambda repressor-like DNA-binding domains
47446               2                90          Signal peptide-binding domain
47459               5                71          Helix-loop-helix DNA-binding domain
47473              35               125          EF-hand
47565               2               122          Insect pheromon/odorant-binding proteins
47571               2               149          Cloroperoxidase
47576               5               114          Calponin-homology domain, CH-domain
47598               5                75          Met repressor-like
47610               2                64          Disulphide-bond formation facilitator (DSBA), insertion domain
47616              16               133          Glutathione S-transferase (GST), C-terminal domain
47661               3               137          t-snare proteins
47699               5               100          Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
47729               6                76          IHF-like DNA-binding proteins
47741               3                88          CO dehydrogenase ISP C-domain like
47769               3                80          SAM/Pointed domain
47781               3               110          RuvA domain 2-like
47789               2                75          C-terminal domain of RNA polymerase alpha subunit
47802               2                88          DNA polymerase beta, N-terminal domain-like
47807               4               113          5' to 3' exonuclease, C-terminal subdomain
47819               2                94          HRDC-like
47823               3               108          lambda integrase-like, N-terminal domain
47836               4               112          Retroviral matrix proteins
47857               2               159          Apolipophorin-III
47862               2                77          Saposin
47874               3               237          Annexin
47895               2               118          Transducin (alpha subunit), insertion domain
47917               2               124          C-terminal domain of alpha and beta subunits of F1 ATP synthase
47923               2               157          Ypt/Rab-GAP domain of gyp1p
47943               3               141          Retrovirus capsid protein, N-terminal core domain
47954              16               122          Cyclin-like
47973               2               153          Ribosomal protein S7
47986              10               102          DEATH domain
48013               2               135          Antitermination factor NusB
48019               4               116          DNA polymerase III clamp loader subunits, C-terminal domain
48034               2                97          Guanido kinase N-terminal domain
48050               2               115          Hemocyanin, N-terminal domain
48056               4               284          Di-copper centre-containing domain
48065               4               205          DBL homology domain (DH-domain)
48081               2               265          Methyl-coenzyme M reductase alpha and beta chain C-terminal domain
48097               5               155          Regulator of G-protein signalling, RGS
48113               4               296          Heme-dependent peroxidases
48150               5               204          DNA-glycosylase
48173               2               258          Cryptochrome/photolyase FAD-binding domain
48179               6               191          6-phosphogluconate dehydrogenase C-terminal domain-like
48208               8               468          Six-hairpin glycosyltransferases
48225               3               480          Seven-hairpin glycosyltransferases
48230               3               343          Chondroitin AC/alginate lyase
48239               6               308          Terpenoid cylases/Protein prenyltransferases
48256               3               394          Citrate synthase
48264               8               417          Cytochrome P450
48283               2                82          FIS-like
48310               2               398          Aldehyde ferredoxin oxidoreductase, C-terminal domains
48317               4               486          Acid phosphatase/Vanadium-dependent haloperoxidase
48334               2               282          DNA repair protein MutS, domain III
48345               2               214          A virus capsid protein alpha-helical domain
48350               4               205          GTPase activation domain, GAP
48371               9               369          ARM repeat
48403               8               176          Ankyrin repeat
48439               2               327          Protein prenylyltransferase
48452               9               202          TPR-like
48464               4               147          ENTH/VHS domain
48484               2               613          Lipoxigenase
48498               2               123          Tetracyclin repressor-like, C-terminal domain
48503               2                48          Skp1-Skp2 dimerisation domains
48508               8               250          Nuclear receptor ligand-binding domain
48537               3               252          Phospholipase C/P1 nuclease
48552               6               169          Serum albumin-like
48557               6               446          L-aspartase-like
48576               6               323          Terpenoid synthases
48592               2               248          GroEL equatorial domain-like chaperone equatorial domain
48600               2               170          Chorismate mutase II
48613               2               206          Heme oxygenase
48619               4               125          Phospholipase A2, PLA2
48670               2                61          Transducin (heterotrimeric G protein), gamma chain
49265              35                97          Fibronectin type III
49303               3               107          beta-Galactosidase/glucuronidase domain
49309               4               105          Transglutaminase, two C-terminal domains
49313               2               107          Cadherin
49319               2               113          Actinoxanthin-like
49329               3               147          Cu,Zn superoxide dismutase-like
49344               2               189          CBD9-like
49348               2               126          Clathrin adaptor appendage domain
49354               3               120          PapD-like
49367               2               106          Superoxide reductase-like
49373               6                94          Invasin/intimin cell-adhesion fragments
49384               7               136          Carbohydrate-binding domain
49401               5               154          Bacterial adhesins
49417               7               184          p53-like transcription factors
49452               3               105          Starch-binding domain
49478               2                93          B repeat unit of collagen binding surface protein (cna)
49482               3               249          Aromatic compound dioxygenase
49493               2                85          HSP40/DnaJ peptide-binding domain
49503              32               146          Cupredoxins
49562              10               133          C2 domain (Calcium/lipid-binding domain, CaLB)
49584               2                85          Periplasmic chaperone C-domain
49599               2               171          TRAF domain-like
49611              31               227          Viral coat and capsid proteins
49695               9                88          gamma-Crystallin-like
49723               4               117          Lipase/lipooxygenase domain (PLAT/LH2 domain)
49742               4               154          PHM/PNGase F
49749               4               313          Viral proteins
49764               3               125          HSP20-like chaperones
49777               3               164          PEBP-like
49785              11               159          Galactose-binding domain-like
49818               6               206          Viral protein domain
49835               3               149          Virus attachment protein
49842               7               145          TNF-like
49854               2               111          Spermadhesin, CUB domain
49863               3                80          Hyaluronate lyase-like, C-terminal domain
49879               3               162          SMAD/FHA domain
49899              26               197          Concanavalin A-like lectins/glucanases
49998               4               428          Copper amine oxidase, domain 3 (catalytic)
50005               2               269          Hyaluronate lyase-like, central domain 
50022               5               130          ISP domain
50037               4                65          C-terminal domain of transcriptional repressors
50044              14                71          SH3-domain
50084               3                45          Myosin S1 fragment, N-terminal domain
50090               4               103          Electron transport accessory proteins
50104               5               100          Translation proteins SH3-like domain
50122               2                50          DNA-binding domain of retroviral integrase
50129               6               166          GroES-like
50156              10                99          PDZ domain-like
50176               2                95          N-terminal domains of the minor coat protein g3p
50182               5                75          Sm-like ribonucleoproteins
50193               2               127          Ribosomal protein L14
50203              13                99          Bacterial enterotoxins
50242               3               145          TIMP-like
50249              39               112          Nucleic acid-binding proteins
50324               2               229          Inorganic pyrophosphatase
50331               7                68          MOP-like
50341               2               141          CheW-like
50346               2               208          Photosynthetic reaction centre, H-chain, cytoplasmic domain
50353               5               141          Cytokine
50370               4               131          Ricin B-like lectins
50382               2               149          Agglutinin
50386               6               192          STI-like
50405               5               118          Actin-crosslinking proteins
50447               6               105          Translation proteins
50465               2               100          EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
50475               4               167          FMN-binding split barrel
50486               2               154          FMT C-terminal domain-like
50494              30               225          Trypsin-like serine proteases
50615               2                74          N-terminal domain of alpha and beta subunits of F1 ATP synthase
50621               2               153          Alanine racemase-like, C-terminal domain
50630               9               324          Acid proteases
50677               3               178          ValRS/IleRS/LeuRS editing domain
50685               2               165          Barwin-like endoglucanases
50692               7               119          ADC-like
50715               3               159          Ribosomal protein L25-like
50729              20               121          PH domain-like
50784               2                48          Transcription factor IIA (TFIIA), N-terminal domain
50789               3               205          Herpes virus serine proteinase, assemblin
50800               5               127          PK beta-barrel domain-like
50814              19               152          Lipocalins
50876               2               119          Avidin/streptavidin
50882               2               102          Metalloprotease inhibitor
50886               2                92          D-aminopeptidase, middle and C-terminal domains
50891               2               164          Cyclophilin (peptidylprolyl isomerase)
50904               2               108          Oncogene products
50911               2               140          Mannose 6-phosphate receptor domain
50916               2               128          Rap30/74 interaction domains
50923               4               197          Hemopexin-like domain
50939               7               402          Sialidases (neuraminidases)
50969               4               349          YVTN repeat-like/Quinoprotein amine dehydrogenase
50978               3               348          WD40-repeat
50985               2               337          RCC1/BLIP-II
50998               3               575          Quinoprotein alcohol dehydrogenase-like
51011              12                78          alpha-Amylases, C-terminal beta-sheet domain
51045               6                38          WW domain
51055               3                53          Carbohydrate binding domain
51069               4               247          Carbonic anhydrase
51096               3               209          delta-Endotoxin (insectocide), middle domain
51101               2               147          Mannose-binding lectins
51126              12               398          Pectin lyase-like
51161               7               224          Trimeric LpxA-like enzymes
51182               8               243          RmlC-like cupins
51197               3               318          Clavaminate synthase-like
51206               5               135          cAMP-binding domain-like
51225               2               110          Fibre shaft of virus attachment proteins
51230               8                90          Single hybrid motif
51246               5                85          Rudiment single hybrid motif
51283               2               127          Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)
51294               4               173          Hedgehog/intein (Hint) domain
51306               4               142          LexA/Signal peptidase
51316               2               137          Mss4-like
51332               2               172          E2 regulatory, transactivation domain
51338               2               141          Composite domain of metallo-dependent hydrolases
51344               2                85          Epsilon subunit of F1F0-ATP synthase N-terminal domain
51351               3               243          Triosephosphate isomerase (TIM)
51366              12               239          Ribulose-phoshate binding barrel
51395              10               390          FMN-linked oxidoreductases
51412               3               343          Inosine monophosphate dehydrogenase (IMPDH)
51419               3               229          PLP-binding barrel
51430               3               299          NAD(P)-linked oxidoreductase
51445              46               360          (Trans)glycosidases
51556               5               326          Metallo-dependent hydrolases
51569              13               297          Aldolase
51604               8               245          Enolase C-terminal domain-like
51621               5               341          Phosphoenolpyruvate/pyruvate domain
51649               3               311          RuBisCo, C-terminal domain
51658               4               375          Xylose isomerase-like
51679               4               305          Bacterial luciferase-like
51695               3               285          Phosphatidylinositol-specific phospholipase C (PI-PLC)
51703               3               500          Cobalamin (vitamin B12)-dependent enzymes
51717               3               259          Dihydropteroate synthetase-like
51726               2               350          Uroporphyrinogen decarboxylase, UROD
51735              49               183          NAD(P)-binding Rossmann-fold domains
51971               6               245          Nucleotide-binding domain
51989               3               330          Cellulases
51998               3               605          PFL-like glycyl radical enzymes
52009               2               128          Phosphohistidine domain
52029               2               172          GroEL apical domain-like
52047               3               363          RNI-like
52058               8               194          L domain-like
52080               2               130          Ribosomal proteins L15p and L18e
52091               2               113          Anti-sigma factor antagonist SpoIIaa
52096              10               263          ClpP/crotonase
52113               5                94          BRCT domain
52121               3               156          Lumazine synthase
52129               5               264          Caspase-like
52141               2               195          DNA glycosylase
52166               2               209          Ribosomal protein L4
52172              13               131          CheY-like
52210               2               161          Succinyl-CoA synthetase domains
52218               7               172          Flavoproteins
52242               4               156          Cobalamin (vitamin B12)-binding domain
52259               2               202          Cutinase-like
52266               4               254          Esterase/acetylhydrolase
52283               8               162          Formate/glycerate dehydrogenase catalytic domain-like
52317               6               196          Class I glutamine amidotransferase-like
52335               3               160          Methylglyoxal synthase-like
52343              10               148          Ferredoxin reductase-like, C-terminal NADP-linked domain
52374              17               305          Nucleotidylyl transferase
52402               6               240          Adenine nucleotide alpha hydrolases-like
52425               3               191          Cryptochrome/photolyase, N-terminal domain
52431               5               181          ETFP adenine nucleotide-binding domain-lik
52440              11               101          PreATP-grasp domain
52467              10               208          DHS-like NAD/FAD-binding domain
52490               2               227          Tubulin, GTPase domain
52499               3               212          Cysteine hydrolase
52507               2               179          DFP DNA/pantothenate metabolism flavoprotein
52518              15               228          Thiamin diphosphate-binding fold (THDP-binding)
52540              63               221          P-loop containing nucleotide triphosphate hydrolases
52743               3               305          Subtilisin-like
52768               2               340          Arginase/deacetylase
52777               3               228          CoA-dependent acyltransferases
52788               2               144          Phosphotyrosine protein phosphatases I
52799              12               234          (Phosphotyrosine protein) phosphatases II
52821               7               142          Rhodanese/Cell cycle control phosphatase
52833              42               109          Thioredoxin-like
52922               3               142          TK C-terminal domain-like
52935               4               130          Pyruvate kinase, C-terminal domain
52943               2               241          ATP syntase (F1-ATPase), gamma subunit
52954               7               108          Anticodon-binding domain of Class II aaRS
52972               2               184          Maf/Ham1
53041               4               170          Resolvase-like
53056               4               208          beta-carbonic anhydrase, cab
53067               7               205          Actin-like ATPase domain
53092               2               165          Creatinase/prolidase N-terminal domain
53098               7               201          Ribonuclease H-like
53137               3               146          Translational machinery components
53150               2               146          DNA repair protein MutS, domain II
53155               3                83          Methylated DNA-protein cysteine methyltransferase domain
53163               2               241          HybD-like
53167               6               254          Purine and uridine phosphorylases
53182               2               215          Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)
53187               8               299          Zn-dependent exopeptidases
53218               3               167          Molybdenum cofactor biosynthesis proteins
53223               7               153          Aminoacid dehydrogenase-like, N-terminal domain
53244               4               135          MurD-like peptide ligases, peptide-binding domain
53254               4               252          Phosphoglycerate mutase-like
53271              14               194          PRTase-like
53300               6               197          vWA-like
53316               2               288          CoA transferase
53328               2               204          Formyltransferase
53335              21               238          S-adenosyl-L-methionine-dependent methyltransferases
53383              31               399          PLP-dependent transferases
53448              13               251          Nucleotide-diphospho-sugar transferases
53474              39               354          alpha/beta-Hydrolases
53590               2               314          Nucleoside hydrolase
53597               8               173          Dihydrofolate reductases
53613               6               324          Ribokinase-like
53623               4               238          MurD-like peptide ligases, catalytic domain
53639               2               214          AraD-like aldolase/epimerase
53649               5               440          Alkaline phosphatase-like
53659               2               392          Isocitrate/Isopropylmalate dehydrogenases
53671               3               153          Aspartate/ornithine carbamoyltransferase
53681               2               126          Aspartate/glutamate racemase
53686               6               358          Tryptophan synthase beta subunit-like PLP-dependent enzymes
53697               4               384          SIS domain
53706               4               612          Formate dehydrogenase/DMSO reductase, domains 1-3
53720               6               474          ALDH-like
53738               6               130          Phosphoglucomutase, first 3 domains
53748               2               415          Phosphoglycerate kinase
53756               3               366          UDP-Glycosyltransferase/glycogen phosphorylase
53795               3               271          PEP carboxykinase-like
53800               3               308          Chelatase
53807               7               400          "Helical backbone" metal receptor
53822              13               376          Periplasmic binding protein-like I
53850              15               255          Periplasmic binding protein-like II
53901              12               193          Thiolase-like
53927               2               147          Cytidine deaminase-like
53933               5               112          Microbial ribonucleases
53955               9               187          Lysozyme-like
54001               9               278          Cysteine proteinases
54060               4               159          His-Me finger endonucleases
54076               4               121          RNase A-like
54098               2               107          Prion-like
54117              10                70          Interleukin 8-like chemokines
54160               5                67          Chromo domain-like
54171               4                75          DNA-binding domain
54184               2                59          Penicillin-binding protein 2x (pbp-2x), c-terminal domain
54189               2               137          Ribosomal proteins L23 and L15e
54197               4               145          HIT-like
54211              11               134          Ribosomal protein S5 domain 2-like
54236              12                94          Ubiquitin-like
54277               4                98          CAD & PB1 domains
54285               3                72          MoaD/ThiS
54292              12               103          2Fe-2S ferredoxin-like
54328               4               114          Staphylokinase/streptokinase
54334               7               111          Superantigen toxins, C-terminal domain
54358               2                64          Immunoglobulin-binding domains
54373              11               101          FAD-linked reductases, C-terminal domain
54403               4               100          Cystatin/monellin
54416               8               104          Copper amine oxidase, domains 1 and 2
54427               7               149          NTF2-like
54452              13               143          MHC antigen-recognition domain
54495               7               151          UBC-like
54506               2               137          Diaminopimelate epimerase
54511               3               225          GFP-like
54523               3               135          Pilin
54534               5               119          FKBP-like
54556               4                73          Chitinase insertion domain
54585               4                97          Cdc48 domain 2-like
54593               7               155          Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
54631               2                56          CBS-domain
54637               4               148          Thioesterase/thiol ester dehydrase-isomerase
54654               3                65          CI-2 family of serine protease inhibitors
54665               4               133          CO dehydrogenase molybdoprotein N-domain-like
54675               2               118          Quinolinic acid phosphoribosyltransferase, N-terminal domain
54680               2               104          Pyrimidine nucleoside phosphorylase C-terminal domain
54695               6                95          POZ domain
54713               3               123          Elongation factor Ts (EF-Ts), dimerisation domain
54719               3               117          Fe,Mn superoxide dismutase (SOD), C-terminal domain
54762               2                74          Signal recognition particle alu RNA binding heterodimer, SRP9/14
54768               5                78          dsRNA-binding domain-like
54791               5                84          Eukaryotic type KH-domain (eKH-domain)
54806               2                75          Alpha-lytic protease prodomain
54814               4                91          Prokaryotic type KH domain (pKH-domain)
54826               8               124          Enolase N-terminal domain-like
54843               2               129          Ribosomal protein L22
54849               2               101          GroEL-intermediate domain like
54862               8                95          4Fe-4S ferredoxins
54897               4               128          Protease propeptides/inhibitors
54928              17                87          RNA-binding domain, RBD
54957               3               101          Viral DNA-binding domain
54966               3               130          RuBisCO, large subunit, small (N-terminal) domain
54980               2                84          EF-G/eEF-2 domains III and V
54984               2                89          eEF-1beta-like
55003               2               137          Poly(A) polymerase, C-terminal domain
55008               8                70          Metal-binding domain
55021               4                86          Regulatory domain in the aminoacid metabolism
55035               2               113          NAD-binding domain of HMG-CoA reductase
55060               2               165          GHMP Kinase
55073               3               204          Adenylyl and guanylyl cyclase catalytic domain
55088               3               233          Methyl-coenzyme M reductase subunits
55103               4               281          FAD-linked oxidases, C-terminal domain
55112               2               148          Formylmethanofuran:tetrahydromethanopterin formyltransferase
55116               2               159          Formiminotransferase domain of formiminotransferase-cyclodeaminase.
55120               4               142          Pseudouridine synthase
55124               2                70          Sulfite reductase, domains 1 and 3
55129               2               107          Ribosomal protein L30p/L7e
55136               2               156          Probable bacterial effector-binding domain
55159               2               104          eIF1-like
55166               2               143          Hedgehog/DD-pepidase
55174               3               124          Alpha-L RNA-binding motif
55190               2               115          Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain
55194               2               184          Ribosome recycling factor, RRF
55205               3               361          EPT/RTPC-like
55221               2               122          Yest killer toxins
55239               2               131          RuBisCO, small subunit
55252               2                71          C-terminal domain of arginine repressor
55257               3               118          RBP11-like subunits of RNA polymerase
55261               2               126          Prokaryotic AspRS, insert domain
55271               2               113          DNA repair protein MutS, domain I
55282               2               159          Ribosomal protein L5
55287               2                78          RPB5-like RNA polymerase subunit
55298               3               126          YjgF-like
55307               3               168          Tubulin, C-terminal domain
55315               4               118          L30e-like
55331               5               106          Tautomerase/MIF
55347               5               137          Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
55387               2               112          Frataxin-like
55394               2               228          Bactericidal permeability-increasing protein, BPI
55405               3               126          RNA bacteriophage capsid protein
55418               2               195          Translation initiation factor eIF4e
55424               8               115          FAD/NAD-linked reductases, dimerisation (C-terminal) domain
55447               3               114          CO dehydrogenase flavoprotein C-terminal domain-like
55455               2                78          SRF-like
55464               2               141          Origin of replication-binding domain, RBD-like
55469               4               218          NADH oxidase/flavin reductase
55486               6               233          Metalloproteases ("zincins"), catalytic domain
55545               2               140          beta-N-acetylhexosaminidase-like domain
55550              13               107          SH2 domain
55594               3                86          HPr-like
55608               7               104          Homing endonucleases
55620               7               155          Tetrahydrobiopterin biosynthesis enzymes-like
55658               2                51          L9 N-domain-like
55666               2                99          Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 2 and 5
55681              14               295          Class II aaRS and biotin synthetases
55711               2               113          Clathrin adaptor appendage domain
55718               2               119          Sterol carrier protein, SCP
55729              10               194          Acyl-CoA N-acyltransferases (Nat)
55753              11               126          Actin depolymerizing proteins
55770               3               130          Profilin (actin-binding protein)
55785               4               117          PYP-like sensor domain (PAS domain)
55797               2               172          PR-1-like
55804               3               196          Phoshotransferase/anion transport protein
55811               4               162          Nudix
55821               2               194          YrdC/RibB
55831               3               259          Thymidylate synthase/dCMP hydroxymethylase
55856               4                86          Cytochrome b5
55874               8               187          ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
55895               4               205          Ribonuclease Rh-like
55909               5               282          Pentein
55920               5               254          Creatinase/aminopeptidase
55931               2               323          Glutamine synthase/guanido kinase
55945               5                99          TATA-box binding protein-like
55961               4               233          Bet v1-like
55973               3               125          S-adenosylmethionine synthetase
55979              12               124          DNA clamp
56003               3               632          Molybdemum cofactor-binding domain
56014               2               158          Sulfite reductase hemoprotein (SiRHP), domains 2 and 4
56024               5               215          Phospholipase D/nuclease
56029               3               111          Monooxygenase (hydroxylase) regulatory protein
56047               2               128          Ribosomal protein S8
56053               4                84          Ribosomal protein L6
56059              14               229          Glutathione synthetase ATP-binding domain-like
56091               4               238          DNA ligase/mRNA capping enzyme, catalytic domain
56104               2               312          SAICAR synthase-like
56112              17               307          Protein kinase-like (PK-like)
56176               8               213          FAD-binding domain
56194               2               125          Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain
56214               3               115          4'-phosphopantetheinyl transferase
56219               4               279          DNase I-like
56235              16               237          N-terminal nucleophile aminohydrolases (Ntn hydrolases)
56281               6               239          Metallo-hydrolase/oxidoreductase
56300               3               297          Metallo-dependent phosphatases
56317               3               281          Nitrilase/N-carbamoyl-D-aminoacid amidohydrolase
56322               3               450          ADC synthase
56327              11               167          Lactate & malate dehydrogenases, C-terminal domain
56349               7               210          DNA breaking-rejoining enzymes
56371               7               253          Ribosome inactivating proteins (RIP)
56399               3               205          ADP-ribosylation
56425               4               132          Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
56436              22               120          C-type lectin-like
56496               3               225          Fibrinogen C-terminal domain-like
56529               3               239          FAH
56542               2               303          Substrate-binding domain of HMG-CoA reductase
56553               2               126          Insert subdomain of RNA polymerase alpha subunit
56568               2                88          Non-globular alpha+beta subunits of globular proteins
56574               9               367          Serpins
56601              12               298          beta-Lactamase/D-ala carboxypeptidase
56634               2               534          Heme-linked catalases
56645               4               232          Acyl-CoA dehydrogenase NM domain-like
56655               6               315          Sugar phosphatases
56712               3               465          Prokaryotic type I DNA topoisomerase
56719               2               578          Type II DNA topoisomerase
56752               4               298          D-aminoacid aminotransferase-like PLP-dependent enzymes
56762               2               510          Nickel-iron hydrogenase, large subunit
56784               6               213          HAD-like
56796               2               372          Dehydroquinate synthase-like
56801               2               516          Firefly luciferase-like
56808               2               215          Ribosomal protein L1
56821               2               592          Prismane protein-like
56837               2               185          Colicin
56849               3               237          delta-Endotoxin (insectocide), N-terminal domain
56854               3               176          Bcl-2 inhibitors of programmed cell death
56918               5                47          Light-harvesting complex subunits
56925               2               142          OMPA-like
56935               8               432          Porins
56959               2               292          Leukocidin (pore-forming toxin)
56994               3                49          Insulin-like
57016               3                39          Plant lectins/antimicrobial peptides
57027               3                32          Plant inhibitors of proteinases and amylases
57038               2                29          Cyclotides
57048               2                36          Gurmarin-like
57059              18                34          omega toxin-like
57095              18                57          Scorpion toxin-like
57184               2                98          Growth factor receptor domain
57190               4                41          Colipase-like
57196              25                44          EGF/Laminin
57243               2                26          Bromelain inhibitor VI (cysteine protease inhibitor)
57247               2                59          Bowman-Birk inhibitor, BBI
57262               2                50          Leech antihemostatic proteins
57283               2                33          PMP inhibitors
57288               2                51          Midkine
57302               9                73          Snake toxin-like
57362               9                58          BPTI-like
57392               9                40          Defensin-like
57414               2                90          Hairpin loop containing domain-like
57424               2                41          LDL receptor-like module
57429               2                45          Crambin-like
57440               6                74          Kringle-like
57467               9                53          Ovomucoid/PCI-1 like inhibitors
57492               2                52          Trefoil
57501              11               108          Cystine-knot cytokines
57535              12                63          Complement control module/SCR domain
57546               2                36          Sea anemone toxin k
57552               2                59          Blood coagulation inhibitor (disintegrin)
57567               4                67          Serine proterase inhibitors
57586               3                54          TNF receptor-like
57603               5                45          Fibronectin type I module
57630               2                46          GLA-domain
57652               4                72          HIPIP (high potential iron protein)
57667              19                32          C2H2 and C2HC zinc fingers
57701               5                44          Zn2/Cys6 DNA-binding domain
57716              13                47          Glucocorticoid receptor-like (DNA-binding domain)
57756               4                33          Retrovirus zinc finger-like domains
57774               3                34          Microbial and mitochondrial ADK, insert "zinc finger" domain
57783               5                56          Zinc beta-ribbon
57802               5                60          Rubredoxin-like
57829               3                73          Zn-binding ribosomal proteins
57850               8                79          RING finger domain, C3HC4
57868               7                39          Metallothionein
57889               4                52          Cysteine-rich domain
57903               4                76          FYVE/PHD zinc finger
57917               2               105          Zn-binding domains of ADDBP
57924               4               113          Inhibitor of apoptosis (IAP) repeat
63380              10               108          Riboflavin synthase domain-like
63393               4                56          RBP12 subunit of RNA polymerase II
63411              13               200          LuxS/MPP-like metallohydrolase
63418               2                81          MurE/MurF N-terminal domain
63451               3                55          LEM domain
63520               2               110          PTS-regulatory domain, PRD
63570               2               102          PABC (PABP) domain
63600               2               191          Telomeric repeat binding factor (TRF) dimerisation domain
63748               2                95          Tudor/PWWP
63862               2                90          Thiamin pyrophosphokinase, substrate-binding domain
63999               2               195          Thiamin pyrophosphokinase, catalytic domain
64005               2               213          Undecaprenyl diphosphate synthase
64268               2               136          PX domain
64307               2                89          SirA-like
64356               2               132          SNARE-like
64501               2               511          Ku heterodimer subunits
68906               2                43          SAP domain
68923               3               225          PEP carboxykinase N-terminal domain
69012               2               153          alpha-ketoacid dehydrogenase kinase, N-terminal domain
69125               2                53          Nuclear receptor coactivator interlocking domain
69179               4               155          Integrin domains
69279               2               174          Phage tail proteins
69287               2                72          Urease metallochaperone UreE, N-terminal domain
69298               2               113          Quinohemoprotein amine dehydrogenase A chain, domain 3
69349               2               189          Phage fibre proteins
69635               4               123          Type III secretory system chaperone
69645               3               150          Arp2/3 complex subunits
69705               2               115          Transcription factor NusA, N-terminal domain
69737               2                67          Urease metallochaperone UreE, C-terminal domain
74650               5               287          Galactose mutarotase-like
74653               2               107          TolA/TonB C-terminal domain
74877               2               126          Major surface antigen p30, SAG1
75217               2               174          alpha/beta knot
75399               2               213          Plakin repeat
75520               2               141          Clathrin coat assembly domain
75689               2                44          Zinc-binding domain of translation initiation factor 2 beta
81271               2                70          TGS-like
81273               2                46          H-NS histone-like proteins
81296              42               122          E set domains
81301               6               276          Nucleotidyltransferase
81383               2                70          F-box domain
81585               2                59          DNA polymerase beta-like, second domain
81593               2               128          Nucleotidyltransferase substrate binding subunit/domain
81624               4               260          N-terminal domain of MutM-like DNA repair proteins
81811               2               105          Helical domain of Sec23/24
81923               2               136          Double Clp-N motif
81986               2               106          Tp47 lipoprotein, middle and C-terminal domains
81995               2               174          beta-sandwich domain of Sec23/24
82057               2                80          GW domain
82153               2               148          FAS1 domain
82199               5               242          SET domain
82693               4               101          Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains
82714               2                90          Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains
82754               2               127          C-terminal, gelsolin-like domain of Sec23/24
82919               2                78          Zn-finger domain of Sec23/24